Strain Name:

B6 x STOCK Tyrc-ch Bmp5se +/+ Myo6sv/J

Stock Number:

000578

Order this mouse

Availability:

Cryopreserved - Ready for recovery

Common Names: C57BL/6J x STOCK Tyrc-ch Bmp5se +/+ Myo6sv/J;    

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Mutant Stock; Spontaneous Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse
Generation+N1
Generation Definitions

Description
Mice homozygous for the Snell's waltzer spontaneous mutation (Myo6sv) show to a marked degree the typical circling, head-tossing, deafness, and hyperactivity of other mutant mice of this type. Homozygous mutant mice are recognizable by the age of 1 week. The abnormalities of the inner ear consist of degeneration of the entire neuroepithelium comprising the organ of Corti, the saccular and utricular maculae, and the cristae of all three semicircular canals. Although viability of homozygotes is nearly normal, breeding ability is reduced and males are more reliable breeders than females.

Specific cytoskeletal components are critical for specific cellular structures. The microvilli of intestinal brush border cells in Myo6sv homozygotes are shorter than normal. While myosin 6 is not critical for the development of hair cell stereocilia, it is essential for their maintenance. At birth the stereocilia appear nearly normal with only occasional stereocilia showing early signs of fusion at their bases, but by 3 days of age most hair cells appear disorganized with full fusing of steriocilia. Continued degeneration yields giant stereocilia by 20 days of age and degeneration of the inner and outer hair cells in the organ of Corti by 6 weeks of age. Reissner's membrane, the stria vascularis, and the spiral ganglion appear normal. At 20 or 30 days of age, direct cochlear stimulation failed to elicit a compound action potential or cochlear microphonic response indicating deafness in Myo6sv homozygotes. A mutation in human MYO6 has been associated with a nonsyndromic dominant form of deafness. (Deol and Green, 1966; Avraham et al., 1995; Self et al., 1999; Melchoinda et al., 2001; Buss et al., 2001.)

Although myosin 6 co-localization with clatherin-coated pits suggests a role in endocytosis, Self et al. reported uptake of the membrane dye FM1-43 by hair cells of 1 and 3 day old Myo6sv mutant mice indicating that endocytosis by hair cells does not require MYO6. Fibroblast cell lines from mice homozygous for the Myo6sv mutation have a 40% reduction in the level of trans-Golgi network secretion to the plasma membrane paralleling a 40% reduction in Golgi volume. Additionally, the mutant Golgi complexes are smaller and more fragmented than normal. Transfection of fibroblasts from Myo6sv homozygotes with full length myosin 6 returns the Golgi morphology and secretion to normal. (Self et al., 1999; Warner et al., 2003.) In addition to cochlear defects, homozygous mice exhibit a significant reduction in the amplitude of a and b waves as measured by electroretinogram, although there is no photoreceptor cell loss. (Kitamoto et al., 2005)

The Snell's waltzer mutation is maintained in repulsion with the closely linked short ear mutation (Bmpse), both located on Chromosome 9.

Development
The chinchilla (Tyrc-ch) mutation arose spontaneously in the 1920's (Feldman H. W. 1922 Am. Nat. 56:573-574). Short ear (Bmp5se) arose spontaneously in mice obtained from a commercial breeder about 1921 (Lynch C.H. 1921 Am. Nat. 55:421-426). The Snell's waltzer (Myo6sv) mutation was found in the B10.HA(33NX) stock of Dr. G.D. Snell at the Jackson Laboratory in the late 1950s. In 1959 an Myo6sv/Myo6sv mouse was crossed to the SEC/1 strain of Dr. M. C. Green. The genotype of SEC/1 was a/a Tyrp1b/Tyrp1b Tyrc-ch/Tyrc-ch Bmp5se/+. A very close linkage was found between Bmp5se and Myo6sv and the two loci were maintained in repulsion. The stock was inbred as Tyrc-ch/Tyrc-ch Bmp5se +/+ Myo6sv and was cryopreserved in 1983 by crossing C57BL/6J females to Tyrc-ch/Tyrc-ch Bmp5se +/+ Myo6sv at F67 to generate embryos.

Control Information

  Control
   ? +/+ ? untested from colony
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Bmp5se allele
000004   ABP/LeJ
000056   B6.Cg-Bmp5se/J
000285   B6.Cg-Rorasg + +/+ Myo5ad Bmp5se/J
000652   BDP/J
000253   DLS/LeJ
000679   P/J
000644   SEA/GnJ
000270   SEC/1GnLeJ
View Strains carrying   Bmp5se     (8 strains)

Strains carrying   Tyrc-ch allele
000091   129T1/Sv-Oca2+ Tyrc-ch Dnd1Ter/J
000619   FS/EiJ
004624   FVB.129P2-Pde6b+ Tyrc-ch Fmr1tm1Cgr/J
004828   FVB.129P2-Pde6b+ Tyrc-ch/AntJ
000271   SH1/LeJ
000306   STOCK Dll3pu + Tyrc-ch/+ Oca2p Tyrc-ch/J
View Strains carrying   Tyrc-ch     (6 strains)

Strains carrying other alleles of Bmp5
001496   B6(Cg)-Bmp5se-4J/J
005348   BALB/cByJ Agtpbp1pcd-3J-Bmp5cfe-se6J/GrsrJ
005420   C;129S7 Gt(ROSA)26Sor-Bmp5cfe-se7J/GrsrJ
005421   CBy;B6-Bmp5cfe-se8J/GrsrJ
View Strains carrying other alleles of Bmp5     (4 strains)

Strains carrying other alleles of Myo6
006124   B6.Cg-Myo6sv-2J/J
005749   C57BL/6J-Myo6sv-3J/J
View Strains carrying other alleles of Myo6     (2 strains)

Strains carrying other alleles of Tyr
000090   129S1/Sv-Oca2+ Tyr+ KitlSl-J/J
005445   A.B6 Tyr+-Cybanmf333/J
005012   A.B6 Tyr+-Myo5ad-l31J/J
002565   A.B6-Tyr+/J
001017   AKXD10/TyJ
000765   AKXD13/TyJ
000954   AKXD15/TyJ
000958   AKXD16/TyJ
001093   AKXD18/TyJ
001062   AKXD21/TyJ
000947   AKXD22/TyJ
000969   AKXD24/TyJ
000777   AKXD6/TyJ
000763   AKXD9/TyJ
000409   B10.129P-H1b Hbbd Tyrc Ea7a/(5M)oSnJ
000418   B10.129P-H1b Tyrc Hbbd/(5M)nSnJ
000432   B10.C-H1b Hbbd Tyrc/(41N)SnJ
000580   B10.D2/nSn-Tyrc-4J/J
000822   B6 x 129S1/SvEi Oca2+ Tyr+-Vsx2or-J/J
017614   B6(Cg)-Tyrc-2J Tg(UBC-mCherry)1Phbs/J
000058   B6(Cg)-Tyrc-2J/J
008647   B6.129P2(Cg)-Trpa1tm1.1Kykw Tyrc-2J/J
000383   B6.C-Tyrc H1b Hbbd/ByJ
013590   B6.Cg-Braftm1Mmcm Ptentm1Hwu Tg(Tyr-cre/ERT2)13Bos/BosJ
003819   B6.Cg-Per2tm1Brd Tyrc-Brd/J
023429   B6.Cg-Tyrc-2J Cdkn1atm1Hpw/J
007484   B6.Cg-Tyrc-2J Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
000035   B6.Cg-Tyrc-J/J
000104   B6.Cg-Tyrc-h/J
005349   B6.Cg-awag Tyrc-2J/GrsrJ
012328   B6.Cg-Tg(Tyr-cre/ERT2)13Bos/J
000054   B6.D2-Tyrc-p/J
023428   B6;129X1-Tyrc-2J Cdkn1atm2Hpw/J
000899   C.B6-Tyr+ Hbbs/J
000339   C3H/HeJ-Tyrc-9J/J
001294   C3H/HeJ-Tyrc-a/J
001002   C57BL/10SnJ-Tyrc-11J/J
021999   C57BL/6NJ-Tyrem3J/GrsrJ
012257   CB6-Tg(Tyr-TAg)BJjw/Mmjax
001006   CBA/J-Tyrc-10J/J
000657   CE/J
007483   FVB.Cg-Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
000494   J.Cg-Oca2+ Tyr+ Lystbg/J
002281   NFS.C58-Tyr+/J
004304   NOD.CBALs-Tyr+/LtJ
001759   STOCK A Tyrc Sha/J
018129   STOCK Fah1R Tyrc/RJ
000006   STOCK Hk Tyrc/J
014173   STOCK Omptm1.1(COP4*/EYFP)Tboz/J
000206   STOCK a/a Tyrc-h/J
View Strains carrying other alleles of Tyr     (50 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Model with phenotypic similarity to human disease where etiologies involve orthologs. Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).
Deafness, Autosomal Dominant 22; DFNA22
Deafness, Autosomal Recessive 37; DFNB37
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Albinism, Ocular, with Sensorineural Deafness   (TYR)
Albinism, Oculocutaneous, Type IA; OCA1A   (TYR)
Albinism, Oculocutaneous, Type IB; OCA1B   (TYR)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Myo6sv/Myo6+

        B6 x STOCK Tyrc-ch Bmp5se +/+ Myo6sv/J
  • hearing/vestibular/ear phenotype
  • reduced linear vestibular evoked potential
    • elevated threshold and reduced amplitudes   (MGI Ref ID J:116914)

Myo6sv/Myo6sv

        B6 x STOCK Tyrc-ch Bmp5se +/+ Myo6sv/J
  • hearing/vestibular/ear phenotype
  • absent linear vestibular evoked potential
    • VESPs are absent at the maximum stimulus intensity used   (MGI Ref ID J:116914)
  • behavior/neurological phenotype
  • abnormal reflex
    • abnormal drop reflex; mice do not demonstrate expected dorsoflexion and spread out the front paws when quickly lowered from ~20 cm above a table surface, while controls do exhibit this behavior   (MGI Ref ID J:116914)
  • circling   (MGI Ref ID J:116914)
  • impaired swimming
    • mice exhibit poor swimming ability; mice can not maneuver in the water and can not remain at the surface   (MGI Ref ID J:116914)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Bmp5se/0 Myo6sv/0 Bmp5se/0 Myo6sv/0

        involves: B10.HA/(33NX)Sn * C57BL/6J
  • mortality/aging
  • partial prenatal lethality
    • The percentage of double homozygotes generated from crosses of double homozygotes with double heterozgyotes in coupling is significantly lower than Mendelian prediction indicating prenatal lethality in the compound homozygote more severe than in either single homozygote   (MGI Ref ID J:5044)

Bmp5se/Bmp5se

        SEC/Gn
  • skeleton phenotype
  • abnormal bone ossification
    • reduced rate of proliferation of osteogenic cells of the periosteum in healing rib fractures   (MGI Ref ID J:13011)
  • abnormal cartilage development
    • cartilage forms more slowly in healing rib fractures   (MGI Ref ID J:13011)

Bmp5se/Bmp5se

        SEC/1Gn
  • skeleton phenotype
  • abnormal cartilage development
    • cartilage forms more slowly in healing rib fractures   (MGI Ref ID J:13011)
  • cardiovascular system phenotype
  • abnormal artery morphology
    • the right renal artery lies ventral to the posterior vena cava rather than dorsal to it as in controls   (MGI Ref ID J:5086)
  • immune system phenotype
  • granulomatous inflammation
    • granulomas are seen on the ventral surface of the central and left lateral lobes of the liver   (MGI Ref ID J:5086)
  • liver/biliary system phenotype
  • abnormal liver morphology
    • increase in liver lesions, mainly due to an increase in granulomas   (MGI Ref ID J:5086)
  • respiratory system phenotype
  • lung cysts
    • have numerous small cysts in the lungs   (MGI Ref ID J:5086)

Myo6sv/Myo6+

        Background Not Specified
  • integument phenotype
  • focal hair loss   (MGI Ref ID J:175295)

Myo6sv/Myo6sv

        involves: B10.HA/(33NX)Sn * C57BL/6J
  • behavior/neurological phenotype
  • hyperactivity   (MGI Ref ID J:29898)
  • stereotypic behavior   (MGI Ref ID J:29898)
    • circling   (MGI Ref ID J:29898)
      • mutants can be identified by circling behavior   (MGI Ref ID J:134368)
    • head bobbing
      • mutants can be identified by head bobbing   (MGI Ref ID J:134368)
    • head tossing   (MGI Ref ID J:29898)
  • growth/size/body phenotype
  • decreased body size
    • slightly reduced body size   (MGI Ref ID J:86379)
  • hearing/vestibular/ear phenotype
  • abnormal cochlear sensory epithelium morphology
    • in adults there was degeneration of the entire neuroepithelium in the inner ear   (MGI Ref ID J:29898)
    • cochlear hair cell degeneration
      • hair cell degeneration apparent by 3 weeks of age   (MGI Ref ID J:29898)
      • cochlear inner hair cell degeneration
        • by 6 weeks of age, inner hair cells in the organ of Corti were lost   (MGI Ref ID J:29898)
      • cochlear outer hair cell degeneration
        • by 6 weeks of age, outer hair cells in the organ of Corti were lost   (MGI Ref ID J:29898)
    • fused inner hair cell stereocilia
      • cochlear hair cells appear to start develop normally, but from around birth these arrays become progressively more disorganized and the stereocilia fuse   (MGI Ref ID J:58030)
      • by 3 days after birth, practically all hair cells are affected, and stereocilia fusion is extensive   (MGI Ref ID J:58030)
    • fused outer hair cell stereocilia
      • cochlear hair cells appear to start develop normally, but from around birth these arrays become progressively more disorganized and the stereocilia fuse   (MGI Ref ID J:58030)
      • by 3 days after birth, practically all hair cells are affected, and stereocilia fusion is extensive   (MGI Ref ID J:58030)
  • absent cochlear nerve compound action potential
    • no action potentials generated in the cochlear nerve by direct cochlear stimulation   (MGI Ref ID J:29898)
  • organ of Corti degeneration
    • in adults   (MGI Ref ID J:29898)
  • reproductive system phenotype
  • reduced fertility
    • both sexes were fertile but with reduced productivity   (MGI Ref ID J:29898)
  • nervous system phenotype
  • absent cochlear nerve compound action potential
    • no action potentials generated in the cochlear nerve by direct cochlear stimulation   (MGI Ref ID J:29898)
  • cochlear hair cell degeneration
    • hair cell degeneration apparent by 3 weeks of age   (MGI Ref ID J:29898)
    • cochlear inner hair cell degeneration
      • by 6 weeks of age, inner hair cells in the organ of Corti were lost   (MGI Ref ID J:29898)
    • cochlear outer hair cell degeneration
      • by 6 weeks of age, outer hair cells in the organ of Corti were lost   (MGI Ref ID J:29898)
  • fused inner hair cell stereocilia
    • cochlear hair cells appear to start develop normally, but from around birth these arrays become progressively more disorganized and the stereocilia fuse   (MGI Ref ID J:58030)
    • by 3 days after birth, practically all hair cells are affected, and stereocilia fusion is extensive   (MGI Ref ID J:58030)
  • fused outer hair cell stereocilia
    • cochlear hair cells appear to start develop normally, but from around birth these arrays become progressively more disorganized and the stereocilia fuse   (MGI Ref ID J:58030)
    • by 3 days after birth, practically all hair cells are affected, and stereocilia fusion is extensive   (MGI Ref ID J:58030)
  • vision/eye phenotype
  • *normal* vision/eye phenotype
    • retinal morphology appears normal; photoreceptor ultrastructure and photoreceptor counts in animals aged 224-303 days are not different from controls   (MGI Ref ID J:134368)
    • abnormal eye electrophysiology
      • in mutants 42-48 days old, a- and b-waves in electroretinogram are reduced in amplitude (25 and 30% respectively) compared to littermate controls   (MGI Ref ID J:134368)
      • intensity-response curves are reduced in amplitude by 20% at flash intensities above 3.0 and 6.0 log units of attenuation for a- and b-waves, respectively000   (MGI Ref ID J:134368)
      • amplitudes are similary reduced in mutants 254-257 days of age   (MGI Ref ID J:134368)

Myo6sv/Myo6sv

        involves: B10.HA/(33NX)Sn * SEC/1Gn
  • hearing/vestibular/ear phenotype
  • abnormal crista ampullaris neuroepithelium morphology
    • degeneration begins at approximately 3 weeks of age, progresses rapidly during the first 2 months then slows   (MGI Ref ID J:5044)
  • abnormal otolithic membrane morphology   (MGI Ref ID J:5044)
  • cochlear degeneration
    • The organ of Corti develops normally until 12 days of age when the hair cells begin to degenerate and by 18 days of age there is considerable degeneration   (MGI Ref ID J:5044)
    • organ of Corti degeneration   (MGI Ref ID J:5044)
    • stria vascularis degeneration
      • degeneration runs parallel with that of the organ of Corti   (MGI Ref ID J:5044)
  • deafness
    • complete deafness with homozygotes failing to respond to sound at any time in their life   (MGI Ref ID J:5044)
  • detached tectorial membrane
    • the tectoral membrane detaches as the hair cells degenerate   (MGI Ref ID J:5044)
  • utricular macular degeneration
    • degeneration does not begin until approximately 3 months of age is is more slow and less complete than degeneration in the macula of the saccule   (MGI Ref ID J:5044)
  • vestibular hair cell degeneration   (MGI Ref ID J:5044)
  • vestibular saccular macula degeneration
    • appears normal until approximately 3 weeks of age   (MGI Ref ID J:5044)
  • behavior/neurological phenotype
  • circling   (MGI Ref ID J:5044)
    • bidirectional circling   (MGI Ref ID J:5044)
  • head tossing   (MGI Ref ID J:5044)
  • hyperactivity
    • near constant hyperactivity when awake   (MGI Ref ID J:5044)
  • impaired swimming
    • fail to orient in water or remain on the surface   (MGI Ref ID J:5044)
  • nervous system phenotype
  • cochlear ganglion degeneration
    • noticeable soon after hair cell degeneration, progressing until nearly absent by a year of age   (MGI Ref ID J:5044)
  • vestibular ganglion degeneration
    • slow, progressive degeneration, differing from that of the spiral ganglion and occurring later   (MGI Ref ID J:5044)
  • vestibular hair cell degeneration   (MGI Ref ID J:5044)

Myo6sv/Myo6sv

        Background Not Specified
  • adipose tissue phenotype
  • decreased percent body fat   (MGI Ref ID J:175295)
  • decreased total body fat amount   (MGI Ref ID J:175295)
  • behavior/neurological phenotype
  • abnormal behavior   (MGI Ref ID J:175295)
    • absent pinna reflex   (MGI Ref ID J:175295)
    • decreased grip strength   (MGI Ref ID J:175295)
    • hyperactivity   (MGI Ref ID J:175295)
    • impaired righting response   (MGI Ref ID J:175295)
    • unresponsive to tactile stimuli   (MGI Ref ID J:175295)
  • endocrine/exocrine gland phenotype
  • enlarged testis   (MGI Ref ID J:175295)
  • growth/size/body phenotype
  • decreased body weight   (MGI Ref ID J:175295)
  • decreased percent body fat   (MGI Ref ID J:175295)
  • decreased total body fat amount   (MGI Ref ID J:175295)
  • homeostasis/metabolism phenotype
  • decreased circulating amylase level   (MGI Ref ID J:175295)
  • decreased circulating cholesterol level   (MGI Ref ID J:175295)
    • decreased circulating HDL cholesterol level   (MGI Ref ID J:175295)
    • decreased circulating LDL cholesterol level   (MGI Ref ID J:175295)
  • increased carbon dioxide production   (MGI Ref ID J:175295)
  • increased circulating chloride level   (MGI Ref ID J:175295)
  • increased energy expenditure   (MGI Ref ID J:175295)
  • increased oxygen consumption   (MGI Ref ID J:175295)
  • integument phenotype
  • abnormal coat/ hair morphology   (MGI Ref ID J:175295)
    • focal hair loss   (MGI Ref ID J:175295)
  • unresponsive to tactile stimuli   (MGI Ref ID J:175295)
  • reproductive system phenotype
  • abnormal external male genitalia morphology   (MGI Ref ID J:175295)
  • enlarged testis   (MGI Ref ID J:175295)
  • skeleton phenotype
  • decreased bone mineral density   (MGI Ref ID J:175295)

Myo6sv/?

        Background Not Specified
  • hearing/vestibular/ear phenotype
  • abnormal auditory brainstem response   (MGI Ref ID J:175295)
  • immune system phenotype
  • decreased IgG3 level   (MGI Ref ID J:175295)
  • integument phenotype
  • abnormal epidermis stratum basale morphology   (MGI Ref ID J:175295)
  • abnormal hair cycle   (MGI Ref ID J:175295)
  • abnormal hair follicle bulge morphology   (MGI Ref ID J:175295)
  • hematopoietic system phenotype
  • decreased IgG3 level   (MGI Ref ID J:175295)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Bmp5se related

Developmental Biology Research
Craniofacial and Palate Defects
Growth Defects
Skeletal Defects

Myo6sv related

Cell Biology Research
Vesicular Trafficking

Neurobiology Research
Hearing Defects
Vestibular Defects

Sensorineural Research
Hearing Defects
Vestibular Defects

Tyrc-ch related

Dermatology Research
Color and White Spotting Defects

Developmental Biology Research
Neurodevelopmental Defects
Skeletal Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Bmp5se
Allele Name short ear
Allele Type Spontaneous
Common Name(s) seGnJ;
Strain of Originmice from Abbie Lathrop mouse farm
Gene Symbol and Name Bmp5, bone morphogenetic protein 5
Chromosome 9
Gene Common Name(s) AU023399; expressed sequence AU023399; se; short ear;
General Note Phenotypic Similarity to Human Syndrome: Ear, Patella, Short Stature Syndrome (Meier-Gorlin Syndrome) in homozygous mice (J:24474)
Molecular Note The C to T transition creates a stop codon at amino acid 208. The resulting truncated protein does not include the carboxy terminal signaling portion of the molecule. [MGI Ref ID J:21484]
 
Allele Symbol Myo6sv
Allele Name Snell's waltzer
Allele Type Spontaneous
Common Name(s) sv;
Strain of OriginB10.HA/(33NX)Sn
Gene Symbol and Name Myo6, myosin VI
Chromosome 9
Gene Common Name(s) BC029719; DFNA22; DFNB37; RGD1560646; Snell's waltzer; Tlc; cDNA sequence BC029719; sv; tailchaser;
Molecular Note On the basis of a series of southern blots, this mutation appears to involve a 1.1 kb intragenic deletion. Gene transcripts could be detected by RT-PCR. Sequence analysis of these transcripts identified a 150 bp deletion corresponding to nucleotides 2456-2585. The deletion results in a frame shift which introduces a stop codon at the beginning of the neck region. [MGI Ref ID J:29898]
 
Allele Symbol Tyrc-ch
Allele Name chinchilla
Allele Type Spontaneous
Common Name(s) cch; cr;
Strain of Originfancier's stock
Gene Symbol and Name Tyr, tyrosinase
Chromosome 7
Gene Common Name(s) ATN; C; CMM8; OCA1; OCA1A; OCAIA; SHEP3; albino; c; skc35; skin/coat color 35;
Molecular Note The mutation in the chinchilla allele was found to be a G to A point mutation that results in an amino acid change at position 464 from alanine to threonine. [MGI Ref ID J:19279]

Genotyping

Genotyping Information

Genotyping Protocols

Bmp5se, Pyrosequencing
Myo6sv, Separated PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Avraham KB; Hasson T; Sobe T; Balsara B; Testa JR; Skvorak AB ; Morton CC ; Copeland NG ; Jenkins NA. 1997. Characterization of unconventional MYO6, the human homologue of the gene responsible for deafness in Snell's waltzer mice. Hum Mol Genet 6(8):1225-31. [PubMed: 9259267]  [MGI Ref ID J:41970]

Deol MS; Green MC. 1966. Snell's waltzer, a new mutation affecting behaviour and the inner ear in the mouse. Genet Res 8(3):339-45. [PubMed: 5980120]  [MGI Ref ID J:5044]

Hasson T; Gillespie PG; Garcia JA; MacDonald RB; Zhao Y; Yee AG; Mooseker MS; Corey DP. 1997. Unconventional myosins in inner-ear sensory epithelia. J Cell Biol 137(6):1287-307. [PubMed: 9182663]  [MGI Ref ID J:44384]

Self T; Sobe T; Copeland NG; Jenkins NA; Avraham KB; Steel KP. 1999. Role of myosin VI in the differentiation of cochlear hair cells. Dev Biol 214(2):331-41. [PubMed: 10525338]  [MGI Ref ID J:58030]

Xiang M; Gao WQ; Hasson T; Shin JJ. 1998. Requirement for Brn-3c in maturation and survival, but not in fate determination of inner ear hair cells. Development 125(20):3935-46. [PubMed: 9735355]  [MGI Ref ID J:43752]

Bmp5se related

Cattanach BM. 1961. A chemically-induced variegated-type position effect in the mouse. Z Vererbungsl 92:165-82. [PubMed: 13877379]  [MGI Ref ID J:160128]

Deol MS; Green MC. 1966. Snell's waltzer, a new mutation affecting behaviour and the inner ear in the mouse. Genet Res 8(3):339-45. [PubMed: 5980120]  [MGI Ref ID J:5044]

DiLeone RJ; Russell LB; Kingsley DM. 1998. An extensive 3' regulatory region controls expression of Bmp5 in specific anatomical structures of the mouse embryo. Genetics 148(1):401-8. [PubMed: 9475750]  [MGI Ref ID J:45426]

GREEN MC. 1958. Effects of the short ear gene in the mouse on cartilage formation in healing bone fractures. J Exp Zool 137(1):75-88. [PubMed: 13563786]  [MGI Ref ID J:13011]

Green EL; Green MC. 1946. Effect of the short ear gene on number of ribs and presacral vertebrae in the house mouse Am Naturalist 80:619-25.  [MGI Ref ID J:100198]

Green EL; Green MC. 1942. The development of three manifestations of the short ear gene in the mouse J Morphol 70:1-19.  [MGI Ref ID J:15478]

Green MC. 1951. Further morphological effects of the short ear gene in the house mouse. J Morphol 88:1-22.  [MGI Ref ID J:13091]

Green MC. 1968. Mechanism of the pleiotropic effects of the short-ear mutant gene in the mouse. J Exp Zool 167(2):129-50. [PubMed: 5692092]  [MGI Ref ID J:5086]

Hashimoto M; Morita H; Ueno N. 2014. Molecular and cellular mechanisms of development underlying congenital diseases. Congenit Anom (Kyoto) 54(1):1-7. [PubMed: 24666178]  [MGI Ref ID J:209580]

Johnson DR. 1976. The interfrontal bone and mutant genes in the mouse. J Anat 121(3):507-13. [PubMed: 1018005]  [MGI Ref ID J:5776]

Jones JM; Huang JD; Mermall V; Hamilton BA; Mooseker MS; Escayg A; Copeland NG; Jenkins NA; Meisler MH. 2000. The mouse neurological mutant flailer expresses a novel hybrid gene derived by exon shuffling between Gnb5 and Myo5a. Hum Mol Genet 9(5):821-8. [PubMed: 10749990]  [MGI Ref ID J:61324]

Kangsamaksin T; Morris RJ. 2011. Bone morphogenetic protein 5 regulates the number of keratinocyte stem cells from the skin of mice. J Invest Dermatol 131(3):580-5. [PubMed: 21179110]  [MGI Ref ID J:182086]

Katagiri T; Boorla S; Frendo JL; Hogan BL; Karsenty G. 1998. Skeletal abnormalities in doubly heterozygous Bmp4 and Bmp7 mice. Dev Genet 22(4):340-8. [PubMed: 9664686]  [MGI Ref ID J:48538]

King JA; Marker PC; Seung KJ; Kingsley DM. 1994. BMP5 and the molecular, skeletal, and soft-tissue alterations in short ear mice. Dev Biol 166(1):112-22. [PubMed: 7958439]  [MGI Ref ID J:21484]

Kingsley DM; Bland AE; Grubber JM; Marker PC; Russell LB; Copeland NG; Jenkins NA. 1992. The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGF beta superfamily. Cell 71(3):399-410. [PubMed: 1339316]  [MGI Ref ID J:3046]

Lacombe D; Toutain A; Gorlin RJ; Oley CA; Battin J. 1994. Clinical identification of a human equivalent to the short ear (se) murine phenotype. Ann Genet 37(4):184-91. [PubMed: 7710253]  [MGI Ref ID J:24474]

Lynch CJ. 1921. Short ears, an autosomal mutation in the house mouse Am Naturalist 55:421-426.  [MGI Ref ID J:14849]

Nadeau JH. 2001. Modifier genes in mice and humans. Nat Rev Genet 2(3):165-74. [PubMed: 11256068]  [MGI Ref ID J:88013]

Oak Ridge National Laboratory. 2005. Information obtained from the Oak Ridge National Laboratory Mutant Mouse Database (ORNL), Oak Ridge, TN Unpublished :.  [MGI Ref ID J:100221]

Pfendler KC; Yoon J; Taborn GU; Kuehn MR; Iannaccone PM. 2000. Nodal and bone morphogenetic protein 5 interact in murine mesoderm formation and implantation. Genesis 28(1):1-14. [PubMed: 11020711]  [MGI Ref ID J:65690]

Russell LB. 1971. Definition of functional units in a small chromosomal segment of the mouse and its use in interpreting the nature of radiation-induced mutations. Mutat Res 11(1):107-23. [PubMed: 5556347]  [MGI Ref ID J:12013]

Sloane JA; Vartanian TK. 2007. Myosin Va controls oligodendrocyte morphogenesis and myelination. J Neurosci 27(42):11366-75. [PubMed: 17942731]  [MGI Ref ID J:126066]

Solloway MJ; Dudley AT; Bikoff EK; Lyons KM; Hogan BL; Robertson EJ. 1998. Mice lacking Bmp6 function. Dev Genet 22(4):321-39. [PubMed: 9664685]  [MGI Ref ID J:48561]

Solloway MJ; Robertson EJ. 1999. Early embryonic lethality in Bmp5;Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup. Development 126(8):1753-68. [PubMed: 10079236]  [MGI Ref ID J:53294]

The Mammalian Genetics Unit at Harwell. 2004. Information obtained from the Mammalian Genetics Unit, Medical Research Council (MRC), Harwell, UK Unpublished :.  [MGI Ref ID J:90559]

Tilleman H; Hakim V; Novikov O; Liser K; Nashelsky L; Di Salvio M; Krauthammer M; Scheffner O; Maor I; Mayseless O; Meir I; Kayam G; Sela-Donenfeld D; Simeone A; Brodski C. 2010. Bmp5/7 in concert with the mid-hindbrain organizer control development of noradrenergic locus coeruleus neurons. Mol Cell Neurosci 45(1):1-11. [PubMed: 20493948]  [MGI Ref ID J:171333]

Myo6sv related

Avraham KB; Hasson T; Steel KP; Kingsley DM; Russell LB; Mooseker MS; Copeland NG; Jenkins NA. 1995. The mouse Snell's waltzer deafness gene encodes an unconventional myosin required for structural integrity of inner ear hair cells. Nat Genet 11(4):369-75. [PubMed: 7493015]  [MGI Ref ID J:29898]

British Society of Audiology short papers meeting on experimental studies of hearing and deafness. Cambridge, UK, 22-23 September 1996. (Self TJ; Avraham K; Steel KP). 1997. British Society of Audiology short papers meeting on experimental studies of hearing and deafness. CambridgA scanning electron microscope study of the development of the mouse mutant Snell's waltzer. Br J Audiol 31(2):73-132 (82 Abstr.). [PubMed: 9183385]  [MGI Ref ID J:39921]

Calderon A; Derr A; Stagner BB; Johnson KR; Martin G; Noben-Trauth K. 2006. Cochlear developmental defect and background-dependent hearing thresholds in the Jackson circler (jc) mutant mouse. Hear Res 221(1-2):44-58. [PubMed: 16962269]  [MGI Ref ID J:113021]

Collaco A; Jakab R; Hegan P; Mooseker M; Ameen N. 2010. Alpha-AP-2 directs myosin VI-dependent endocytosis of cystic fibrosis transmembrane conductance regulator chloride channels in the intestine. J Biol Chem 285(22):17177-87. [PubMed: 20351096]  [MGI Ref ID J:163890]

Deol MS; Green MC. 1966. Snell's waltzer, a new mutation affecting behaviour and the inner ear in the mouse. Genet Res 8(3):339-45. [PubMed: 5980120]  [MGI Ref ID J:5044]

Giese AP; Ezan J; Wang L; Lasvaux L; Lembo F; Mazzocco C; Richard E; Reboul J; Borg JP; Kelley MW; Sans N; Brigande J; Montcouquiol M. 2012. Gipc1 has a dual role in Vangl2 trafficking and hair bundle integrity in the inner ear. Development 139(20):3775-85. [PubMed: 22991442]  [MGI Ref ID J:187738]

Green MC. 1960. New mutant - Snell's waltzer - sv Mouse News Lett 23:34.  [MGI Ref ID J:26342]

Heidrych P; Zimmermann U; Kuhn S; Franz C; Engel J; Duncker SV; Hirt B; Pusch CM; Ruth P; Pfister M; Marcotti W; Blin N; Knipper M. 2009. Otoferlin interacts with myosin VI: implications for maintenance of the basolateral synaptic structure of the inner hair cell. Hum Mol Genet 18(15):2779-90. [PubMed: 19417007]  [MGI Ref ID J:150214]

Jones SM; Johnson KR; Yu H; Erway LC; Alagramam KN; Pollak N; Jones TA. 2005. A quantitative survey of gravity receptor function in mutant mouse strains. J Assoc Res Otolaryngol 6(4):297-310. [PubMed: 16235133]  [MGI Ref ID J:116914]

Karolyi IJ; Probst FJ; Beyer L; Odeh H; Dootz G; Cha KB; Martin DM; Avraham KB; Kohrman D; Dolan DF; Raphael Y; Camper SA. 2003. Myo15 function is distinct from Myo6, Myo7a and pirouette genes in development of cochlear stereocilia. Hum Mol Genet 12(21):2797-805. [PubMed: 12966030]  [MGI Ref ID J:86379]

Kitamoto J; Libby RT; Gibbs D; Steel KP; Williams DS. 2005. Myosin VI is required for normal retinal function. Exp Eye Res 81(1):116-20. [PubMed: 15978262]  [MGI Ref ID J:134368]

Lewis MA; Quint E; Glazier AM; Fuchs H; De Angelis MH; Langford C; van Dongen S; Abreu-Goodger C; Piipari M; Redshaw N; Dalmay T; Moreno-Pelayo MA; Enright AJ; Steel KP. 2009. An ENU-induced mutation of miR-96 associated with progressive hearing loss in mice. Nat Genet 41(5):614-8. [PubMed: 19363478]  [MGI Ref ID J:151354]

Mouse Genome Informatics and the Wellcome Trust Sanger Institute Mouse Genetics Project (MGP). 2011. Obtaining and Loading Phenotype Annotations from the Wellcome Trust Sanger Institute (WTSI) Mouse Resources Portal Database Release :.  [MGI Ref ID J:175295]

Naccache SN; Hasson T; Horowitz A. 2006. Binding of internalized receptors to the PDZ domain of GIPC/synectin recruits myosin VI to endocytic vesicles. Proc Natl Acad Sci U S A 103(34):12735-40. [PubMed: 16908842]  [MGI Ref ID J:112916]

Oak Ridge National Laboratory. 2005. Information obtained from the Oak Ridge National Laboratory Mutant Mouse Database (ORNL), Oak Ridge, TN Unpublished :.  [MGI Ref ID J:100221]

Osterweil E; Wells DG; Mooseker MS. 2005. A role for myosin VI in postsynaptic structure and glutamate receptor endocytosis. J Cell Biol 168(2):329-38. [PubMed: 15657400]  [MGI Ref ID J:95877]

Puri C. 2009. Loss of myosin VI no insert isoform (NoI) induces a defect in clathrin-mediated endocytosis and leads to caveolar endocytosis of transferrin receptor. J Biol Chem 284(50):34998-5014. [PubMed: 19840950]  [MGI Ref ID J:157795]

Roux I; Hosie S; Johnson SL; Bahloul A; Cayet N; Nouaille S; Kros CJ; Petit C; Safieddine S. 2009. Myosin VI is required for the proper maturation and function of inner hair cell ribbon synapses. Hum Mol Genet 18(23):4615-28. [PubMed: 19744958]  [MGI Ref ID J:153972]

Self T; Sobe T; Copeland NG; Jenkins NA; Avraham KB; Steel KP. 1999. Role of myosin VI in the differentiation of cochlear hair cells. Dev Biol 214(2):331-41. [PubMed: 10525338]  [MGI Ref ID J:58030]

Yano H; Ninan I; Zhang H; Milner TA; Arancio O; Chao MV. 2006. BDNF-mediated neurotransmission relies upon a myosin VI motor complex. Nat Neurosci 9(8):1009-18. [PubMed: 16819522]  [MGI Ref ID J:111724]

Tyrc-ch related

Anderson PD; Lam MY; Poirier C; Bishop CE; Nadeau JH. 2009. The role of the mouse y chromosome on susceptibility to testicular germ cell tumors. Cancer Res 69(8):3614-8. [PubMed: 19351821]  [MGI Ref ID J:147731]

Beermann F; Ruppert S; Hummler E; Bosch FX; Muller G; Ruther U; Schutz G. 1990. Rescue of the albino phenotype by introduction of a functional tyrosinase gene into mice. EMBO J 9(9):2819-26. [PubMed: 2118105]  [MGI Ref ID J:19279]

Bhattacharya C; Aggarwal S; Zhu R; Kumar M; Zhao M; Meistrich ML; Matin A. 2007. The mouse dead-end gene isoform alpha is necessary for germ cell and embryonic viability. Biochem Biophys Res Commun 355(1):194-9. [PubMed: 17291453]  [MGI Ref ID J:118625]

Cattanach BM. 1961. A chemically-induced variegated-type position effect in the mouse. Z Vererbungsl 92:165-82. [PubMed: 13877379]  [MGI Ref ID J:160128]

Dobkin C; Rabe A; Dumas R; El Idrissi A; Haubenstock H; Brown WT. 2000. Fmr1 knockout mouse has a distinctive strain-specific learning impairment. Neuroscience 100(2):423-9. [PubMed: 11008180]  [MGI Ref ID J:119166]

Dunn LC. 1936. Studies on multiple allelomorphic series in the house mouse. I. Description of agouti and albino series of allelomorphs J Genet 33:443-53.  [MGI Ref ID J:22600]

Erickson RP; Gluecksohn-Waelsch S; Cori CF. 1968. Glucose-6-phosphatase deficiency caused by radiation-induced alleles at the albino locus in the mouse. Proc Natl Acad Sci U S A 59(2):437-44. [PubMed: 4296364]  [MGI Ref ID J:5063]

Errijgers V; Van Dam D; Gantois I; Van Ginneken CJ; Grossman AW; D'Hooge R; De Deyn PP; Kooy RF. 2007. FVB.129P2-Pde6b(+) Tyr(c-ch)/Ant, a sighted variant of the FVB/N mouse strain suitable for behavioral analysis. Genes Brain Behav 6(6):552-7. [PubMed: 17083330]  [MGI Ref ID J:137779]

Feldman HW. 1935. A fifth allelomorph in the albino series of the house mouse J Mammal 16:207-210.  [MGI Ref ID J:83666]

Feldman HW. 1922. A fourth allelomorph in the albino series in mice Am Naturalist 56:573-574.  [MGI Ref ID J:14850]

Klebig ML; Kwon BS; Rinchik EM. 1992. Physical analysis of murine albino deletions that disrupt liver-specific gene regulation or mesoderm development. Mamm Genome 2(1):51-63. [PubMed: 1543902]  [MGI Ref ID J:1540]

Laiosa MD; Lai ZW; Thurmond TS; Fiore NC; DeRossi C; Holdener BC; Gasiewicz TA; Silverstone AE. 2002. 2,3,7,8-tetrachlorodibenzo-p-dioxin causes alterations in lymphocyte development and thymic atrophy in hemopoietic chimeras generated from mice deficient in ARNT2. Toxicol Sci 69(1):117-24. [PubMed: 12215665]  [MGI Ref ID J:113951]

Lamoreux ML; Wakamatsu K; Ito S. 2001. Interaction of major coat color gene functions in mice as studied by chemical analysis of eumelanin and pheomelanin. Pigment Cell Res 14(1):23-31. [PubMed: 11277491]  [MGI Ref ID J:103803]

Lighthouse JK; Zhang L; Hsieh JC; Rosenquist T; Holdener BC. 2010. MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm. Dev Dyn :. [PubMed: 21061374]  [MGI Ref ID J:168622]

Lossie AC; Nakamura H; Thomas SE; Justice MJ. 2005. Mutation of l7Rn3 shows that Odz4 is required for mouse gastrulation. Genetics 169(1):285-99. [PubMed: 15489520]  [MGI Ref ID J:96673]

Lyon MF. 1963. Attempts to test the inactive-X theory of dosage compensation in mammals Genet Res 4:93-103.  [MGI Ref ID J:272]

Medical Research Council (MRC) Harwell. 2012. Direct Data Submission 2012/01/26 MGI Direct Data Submission :.  [MGI Ref ID J:179802]

Moyer FH. 1966. Genetic variations in the fine structure and ontogeny of mouse melanin granules. Am Zool 6(1):43-66. [PubMed: 5902512]  [MGI Ref ID J:5001]

Pietropaolo S; Guilleminot A; Martin B; D'Amato FR; Crusio WE. 2011. Genetic-background modulation of core and variable autistic-like symptoms in Fmr1 knock-out mice. PLoS One 6(2):e17073. [PubMed: 21364941]  [MGI Ref ID J:171069]

RUSSELL ES. 1949. A quantitative histological study of the pigment found in the coat-color mutants of the house mouse; interdependence among the variable granule attributes. Genetics 34(2):133-45. [PubMed: 18117146]  [MGI Ref ID J:148461]

Russell ES. 1948. A Quantitative Histological Study of the Pigment Found in the Coat Color Mutants of the House Mouse. II. Estimates of the Total Volume of Pigment. Genetics 33(3):228-36. [PubMed: 17247280]  [MGI Ref ID J:148462]

Russell ES. 1946. A Quantitative Histological Study of the Pigment Found in the Coat-Color Mutants of the House Mouse. I. Variable Attributes of the Pigment Granules. Genetics 31(3):327-46. [PubMed: 17247200]  [MGI Ref ID J:148463]

Schedl A; Ruppert S; Kelsey G; Thies E; Niswander L; Magnuson T; Klebig ML; Rinchik EM; Schutz G. 1992. Chromosome jumping from flanking markers defines the minimal region for alf/hsdr-1 within the albino-deletion complex. Genomics 14(2):288-97. [PubMed: 1427845]  [MGI Ref ID J:2638]

Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York.  [MGI Ref ID J:78801]

Staats J. 1985. Standardized Nomenclature for Inbred Strains of Mice: eighth listing. Cancer Res 45(3):945-77. [PubMed: 3971387]  [MGI Ref ID J:50296]

Strumbos JG; Brown MR; Kronengold J; Polley DB; Kaczmarek LK. 2010. Fragile X mental retardation protein is required for rapid experience-dependent regulation of the potassium channel Kv3.1b. J Neurosci 30(31):10263-71. [PubMed: 20685971]  [MGI Ref ID J:162850]

Sweet HO. 1987. Acromelanic (c<a>) Mouse News Lett 78:56.  [MGI Ref ID J:14994]

Takeuchi S; Yamamoto H; Takeuchi T. 1988. Expression of tyrosinase gene in mice Genome 30(Suppl 1):260 (Abstr.).  [MGI Ref ID J:30744]

Townsend D; Witkop CJ Jr; Mattson J. 1981. Tyrosinase subcellular distribution and kinetic parameters in wild type and C-locus mutant C57BL/6J mice. J Exp Zool 216(1):113-9. [PubMed: 6793688]  [MGI Ref ID J:6611]

Vasiliou V; Buetler T; Eaton DL; Nebert DW. 2000. Comparison of oxidative stress response parameters in newborn mouse liver versus simian virus 40 (SV40)-transformed hepatocyte cell lines. Biochem Pharmacol 59(6):703-12. [PubMed: 10677587]  [MGI Ref ID J:60274]

Vasiliou V; Reuter SF; Nebert DW. 1997. Extrahepatic expression of NAD(P)H:menadione oxidoreductase, UDP glucuronosyltransferase-1A6, microsomal aldehyde dehydrogenase, and hepatic nuclear factor-1 alpha mRNAs in ch/ch and 14CoS/14CoS mice. Biochem Biophys Res Commun 233(3):631-6. [PubMed: 9168903]  [MGI Ref ID J:40515]

Wu M; Rinchik EM; Wilkinson E; Johnson DK. 1997. Inherited somatic mosaicism caused by an intracisternal A particle insertion in the mouse tyrosinase gene. Proc Natl Acad Sci U S A 94(3):890-4. [PubMed: 9023352]  [MGI Ref ID J:38209]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3300.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery of Strains Needing Progeny Testing
    At least two untested males and two untested females (two pairs) will be recovered (eight or more mice is typical). The total number of animals provided, their gender and genotype will vary. Untested animals typically are available to ship between 10 and 14 weeks from the date of your order. If the first recovery attempt is unsuccessful, a second recovery will be done, extending the overall recovery time to approximately 25 weeks. Progeny testing is required to identify the genotype of mice of this strain, as a genotyping assay is not available. This type of testing involves breeding the recovered animals and assessing the phenotype of the offspring in order to identify animals carrying the mutation of interest. We can perform the progeny testing for you as a service or we can ship all recovered animals to you for progeny testing at your facility. If you perform the progeny testing, there is no guarantee that a carrier will be identified. If we perform progeny testing as a service, additional breeding time will be required. In this case, when a male and female (one pair) are identified that carry the mutation, they and their offspring will be shipped. Delivery time for strains requiring progeny testing often exceeds 25 weeks and may take 12 months or more due to the difficulties in breeding some strains. The progeny testing cost is in addition to the recovery cost and is based on the number of boxes used and the time taken to produce the mice identified as carrying the mutation.
    Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation.

    Please contact Customer Service for more information on the cost of progeny testing for a strain, tel: 1-800-422-6423 or 1-207-288-5845 (from any location). The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $4290.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery of Strains Needing Progeny Testing
    At least two untested males and two untested females (two pairs) will be recovered (eight or more mice is typical). The total number of animals provided, their gender and genotype will vary. Untested animals typically are available to ship between 10 and 14 weeks from the date of your order. If the first recovery attempt is unsuccessful, a second recovery will be done, extending the overall recovery time to approximately 25 weeks. Progeny testing is required to identify the genotype of mice of this strain, as a genotyping assay is not available. This type of testing involves breeding the recovered animals and assessing the phenotype of the offspring in order to identify animals carrying the mutation of interest. We can perform the progeny testing for you as a service or we can ship all recovered animals to you for progeny testing at your facility. If you perform the progeny testing, there is no guarantee that a carrier will be identified. If we perform progeny testing as a service, additional breeding time will be required. In this case, when a male and female (one pair) are identified that carry the mutation, they and their offspring will be shipped. Delivery time for strains requiring progeny testing often exceeds 25 weeks and may take 12 months or more due to the difficulties in breeding some strains. The progeny testing cost is in addition to the recovery cost and is based on the number of boxes used and the time taken to produce the mice identified as carrying the mutation.
    Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation.

    Please contact Customer Service for more information on the cost of progeny testing for a strain, tel: 1-800-422-6423 or 1-207-288-5845 (from any location). The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

General Supply Notes

  • View the complete collection of spontaneous mutants in the Mouse Mutant Resource.

Control Information

  Control
   ? +/+ ? untested from colony
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


(6.8)