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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
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- Purchasing information
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Description
Strain Information
Former Names T16H (Changed: 15-DEC-04 ) Type Chromosome Aberration; Translocation; Additional information on Mice with Chromosomal Aberrations. Type Mutant Stock; Additional information on Genetically Engineered Mutant Mice. Species laboratory mouse Development
The T(X;16)16H translocation was identified in the 1960s and maintained on a non-inbred background by Anthony Searle, at MRC Harwell. The colony at The Jackson Laboratory is designated "STOCK" to indicate that its genetic background is a combination of C57BL/6J and CBA/J and the passenger genome from the stock of origin flanking the translocation breakpoints. Attempts to transfer this translocation onto an inbred strain background were not successful due to breeding difficulties encountered after a few generations of backcrossing, suggesting the need for some degree of hybrid vigor. For a time, hybrid vigor was occasionally refreshed by outcrossing to a (C57BL/6J-Aw-J x CBA/CaJ)F1. Many generations of colony breeding without refreshment proved this practice unnecessary, and so it was discontinued.
Related Strains
Reciprocal Translocations
View Reciprocal Translocations (47 strains)
000314 B6CBACa Aw-J/A-EdaTa/J-XO 000287 B6CBACa Aw-J/A-Plp1jp EdaTa/J 000569 C57BL/6J-Aw-J-EdaTa +/+ ArTfm/J
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
EdaTa relatedResearch Tools
Genetics Research
Dermatology Research
Color and White Spotting Defects
Skin and Hair Texture Defects
Developmental Biology Research
Eye Defects
Mouse/Human Gene Homologs
hypohidrotic ectodermal dysplasia
Sensorineural Research
Eye Defects
Genes & Alleles
Gene & Allele Information
| Allele Symbol | EdaTa | ||
|---|---|---|---|
| Allele Name | tabby | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | Ta; TaFa; Taf; | ||
| Strain of Origin | stock including A, C57BL, CBA, and RIII | ||
| Gene Symbol and Name | Eda, ectodysplasin-A | ||
| Chromosome | X | ||
| Gene Common Name(s) | ED1; ED1-A1; ED1-A2; EDA1; EDA2; Eda-A1; Eda-A2; HED; RGD1563178; Ta; XHED; XLHED; tabby; | ||
| General Note | This mutation arose in a strain selected for large size. Hemizygous mutant males breed satisfactorily, but homozygous mutant females are often sterile. Hemizygous mutant females are fully fertile (J:249).Hemizygous males and homozygous females are identical in phenotype with homozygous crinkled (Edaraddcr) and downless (Edardl) mice and with homozygous or heterozygous sleek (Dlslk) mice. They are characterized by absence of guard hairs and zigzags in the coat, a bald patch behind the ear, bald tail with a few kinks near the tip, reduced aperture of the eyelids, a respiratory disorder, and a modified agouti pattern (J:249). The number of vibrissae is reduced (J:14912). The incisors may be reduced or absent, and the molars are usually smaller than normal with the third molar often absent (J:5018, J:5138). There are defects of many endocrine glands. The structures affected by the mutation all arise embryologically as downgrowths of solid epithelial cords, not by invagination with a lumen or by outgrowths from deep grooves (J:5246).Hemizygous mutant females are most easily recognized if they are agouti, in which case they show transverse stripes of light-colored normal and dark tabby hair. They have normal incisors but may have mutant or intermediate-type molars (J:5138). A small proportion of heterozygous females may show some slight defects of some of the exocrine glands (J:5193).In the development of the coat of homozygous and hemizygous mutant mice, hair follicle initiation begins at 17 days of gestation, 3 days later than normal, and ends 1 or 2 days after birth, several days earlier than normal. The hairs are of only one type and resemble abnormal awls (J:12100, J:5137). By use of dermal--epidermal recombination grafts of embryonic flank skin, it was shown that EdaTa acts in the epidermis in its effects on structure of the hairs (J:6041). The effect of the mutation in preventing growth of hair on the tail may be either dermal or epidermal. The mutation may act directly on hair cells or via a diffusible product (J:7450). The phenotype of EdaTa/+ females has been extensively studied because of its relevance to the X-inactivation theory of dosage compensation (J:5018, J:5238).EdaTa and the related mutations Edaraddcr and Edardl disrupt normal development of certain epidermal derivatives, including sweat glands. Although the sensory innervation of footpad skin and the sympathetic innervation of blood vessels in the foot pad is normal in these mutants, the sympathetic fibers that normally innervate the sweat glands fail to develop (J:19910).A candidate gene for the human familial X-linked disorder hypohidrotic ectodermal dysplasia (EDA)(OMIM 305100) has been partially cloned. Eda, a candidate for which has also been cloned, is the homologous gene in the mouse, on the basis of phenotype - hypoplasia of sweat glands, teeth, and hair - and of homologous mapping. There is high sequence identity between the cloned portions of the two genes. Known Eda mutations have been identified in the candidate mouse gene. An extracellular collagenous domain of the mouse gene, not yet identified in the EDA gene, may represent the location of mutations in 85-90% of human families (J:42614). A mouse gene Eda (ectodysplasin-A) has been proposed as the site of the tabby mutations (J:44605).Exogenous epidermal growth factor can reverse phenotypic features of EdaTa mice, advancing the delayed opening of eyelids and eruption of incisors (J:42661) and inducing development of dermal ridges and functional sweat glands (J:42660). Expression of epidermal growth factor receptor is reduced in EDA and in EdaTa mice (J:33361). | ||
| Molecular Note | This allele is characterized by an ~ 2 kb deletion: Genomic DNA was hybridized with an exon 1 probe showing a deletion including the coding region and primers for DNA flanking exon 1 failed to amplify in a PCR assay. [MGI Ref ID J:42614] [MGI Ref ID J:44605] | ||
| Gene Symbol and Name | T(X;16)16H, reciprocal translocation, Chr X and 16, Harwell 16 | ||
| Chromosome | 16 | ||
| Gene Common Name(s) | Searle's translocation; T16H; | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Optimizing PCR Protocols
References
References
Additional References
EdaTa relatedAberg T; Wang XP; Kim JH; Yamashiro T; Bei M; Rice R; Ryoo HM; Thesleff I. 2004. Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis. Dev Biol 270(1):76-93. [PubMed: 15136142] [MGI Ref ID J:92174]
Blecher SR; Kapalanga J; Lalonde D. 1990. Induction of sweat glands by epidermal growth factor in murine X-linked anhidrotic ectodermal dysplasia. Nature 345(6275):542-4. [PubMed: 2348861] [MGI Ref ID J:42660]
Boran T; Lesot H; Peterka M; Peterkova R. 2005. Increased apoptosis during morphogenesis of the lower cheek teeth in tabby/EDA mice. J Dent Res 84(3):228-33. [PubMed: 15723861] [MGI Ref ID J:112546]
Cerghet M; Bessert DA; Nave KA; Skoff RP. 2001. Differential expression of apoptotic markers in jimpy and in Plp overexpressors: evidence for different apoptotic pathways. J Neurocytol 30(9-10):841-55. [PubMed: 12165674] [MGI Ref ID J:121313]
Claxton JH. 1967. The initiation and development of the hair follicle population in tabby mice. Genet Res 10:161-171. [MGI Ref ID J:12100]
Dulos GJ; Bagchus WM. 2001. Androgens indirectly accelerate thymocyte apoptosis. Int Immunopharmacol 1(2):321-8. [PubMed: 11360932] [MGI Ref ID J:109877]
FALCONER DS. 1953. [Total sex-linkage in the house mouse.] Z Indukt Abstamm Vererbungsl 85(2):210-9. [PubMed: 13103353] [MGI Ref ID J:249]
Falconer DS; Latyszewski M. 1952. The environment in relation to selection for size in mice J Genet 51:67-80. [MGI Ref ID J:78116]
Ferguson BM; Brockdorff N; Formstone E; Ngyuen T; Kronmiller JE; Zonana J. 1997. Cloning of Tabby, the murine homolog of the human EDA gene: evidence for a membrane-associated protein with a short collagenous domain. Hum Mol Genet 6(9):1589-94. [PubMed: 9285798] [MGI Ref ID J:42614]
Fliniaux I; Mikkola ML; Lefebvre S; Thesleff I. 2008. Identification of dkk4 as a target of Eda-A1/Edar pathway reveals an unexpected role of ectodysplasin as inhibitor of Wnt signalling in ectodermal placodes. Dev Biol 320(1):60-71. [PubMed: 18508042] [MGI Ref ID J:138365]
Fraser AS; Kindred BM. 1960. Selection for an invariant character, vibrissa number, in the house mouse. II. Limits to variability Aust J Biol Sci 13:48-58. [MGI Ref ID J:14912]
Gruneberg H. 1965. Genes and genotypes affecting the teeth of the mouse. J Embryol Exp Morphol 14(2):137-59. [PubMed: 5893447] [MGI Ref ID J:12999]
Gruneberg H. 1971. The glandular aspects of the tabby syndrome in the mouse. J Embryol Exp Morphol 25(1):1-19. [PubMed: 5548211] [MGI Ref ID J:5193]
Gruneberg H. 1966. The molars of the tabby mouse, and a test of the 'single-active X-chromosome' hypothesis. J Embryol Exp Morphol 15(2):223-44. [PubMed: 5959976] [MGI Ref ID J:5018]
Gruneberg H. 1971. The tabby syndrome in the mouse. Proc R Soc Lond B Biol Sci 179(55):139-56. [PubMed: 4399988] [MGI Ref ID J:5246]
Gruneberg H. 1969. Threshold phenomena versus cell heredity in the manifestation of sex-linked genes in mammals. J Embryol Exp Morphol 22(2):145-79. [PubMed: 5361553] [MGI Ref ID J:5137]
Guidry G; Landis SC. 1998. Target-dependent development of the vesicular acetylcholine transporter in rodent sweat gland innervation. Dev Biol 199(2):175-84. [PubMed: 9698438] [MGI Ref ID J:107703]
Hammerschmidt B; Schlake T. 2007. Localization of Shh expression by Wnt and Eda affects axial polarity and shape of hairs. Dev Biol 305(1):246-61. [PubMed: 17376426] [MGI Ref ID J:121316]
Harsan L; Jalabi W; Grucker D; Ghandour MS. 2004. New insights on neuronal alterations in jimpy mutant brain. Neurochem Res 29(5):943-52. [PubMed: 15139292] [MGI Ref ID J:106214]
Isaacs K; Brown G; Moore GP. 1998. Interactions between epidermal growth factor and the Tabby mutation in skin. Exp Dermatol 7(5):273-80. [PubMed: 9832315] [MGI Ref ID J:53635]
Jamieson RV; Zhou SX; Wheatley SC; Koopman P; Tam PP. 1998. Sertoli cell differentiation and Y-chromosome activity: a developmental study of X-linked transgene activity in sex-reversed X/XSxra mouse embryos. Dev Biol 199(2):235-44. [PubMed: 9698443] [MGI Ref ID J:107693]
Jaskoll T; Zhou YM; Trump G; Melnick M. 2003. Ectodysplasin receptor-mediated signaling is essential for embryonic submandibular salivary gland development. Anat Rec A Discov Mol Cell Evol Biol 271(2):322-31. [PubMed: 12629675] [MGI Ref ID J:105968]
Johnston DS; Russell LD; Friel PJ; Griswold MD. 2001. Murine germ cells do not require functional androgen receptors to complete spermatogenesis following spermatogonial stem cell transplantation. Endocrinology 142(6):2405-8. [PubMed: 11356688] [MGI Ref ID J:109878]
Kangas AT; Evans AR; Thesleff I; Jernvall J. 2004. Nonindependence of mammalian dental characters. Nature 432(7014):211-4. [PubMed: 15538367] [MGI Ref ID J:94561]
Kapalanga J; Blecher SR. 1990. Effect of the X-linked gene Tabby (Ta) on eyelid opening and incisor eruption in neonatal mice is opposite to that of epidermal growth factor. Development 108(2):349-55. [PubMed: 2351074] [MGI Ref ID J:42661]
Knapp PE; Dutta S; Skoff RP. 1990. Differences in levels of neuroglial cell death in jimpy male mice and carrier females. Dev Neurosci 12(3):145-52. [PubMed: 2364893] [MGI Ref ID J:116371]
Knapp PE; Skoff RP. 1993. Jimpy mutation affects astrocytes: lengthening of the cell cycle in vitro. Dev Neurosci 15(1):31-6. [PubMed: 8269866] [MGI Ref ID J:116364]
Koppinen P; Pispa J; Laurikkala J; Thesleff I; Mikkola ML. 2001. Signaling and subcellular localization of the TNF receptor Edar. Exp Cell Res 269(2):180-92. [PubMed: 11570810] [MGI Ref ID J:71957]
Kosaras B; Kirschner DA. 1990. Radial component of CNS myelin: junctional subunit structure and supramolecular assembly. J Neurocytol 19(2):187-99. [PubMed: 2113569] [MGI Ref ID J:121320]
Kristenova P; Peterka M; Lisi S; Gendrault JL; Lesot H; Peterkova R. 2002. Different morphotypes of functional dentition in the lower molar region of tabby (EDA) mice. Orthod Craniofac Res 5(4):205-14. [PubMed: 12416535] [MGI Ref ID J:103894]
Langton AK; Herrick SE; Headon DJ. 2008. An extended epidermal response heals cutaneous wounds in the absence of a hair follicle stem cell contribution. J Invest Dermatol 128(5):1311-8. [PubMed: 18037901] [MGI Ref ID J:135502]
Laurikkala J; Mikkola M; Mustonen T; Aberg T; Koppinen P; Pispa J; Nieminen P; Galceran J; Grosschedl R; Thesleff I. 2001. TNF signaling via the ligand-receptor pair ectodysplasin and edar controls the function of epithelial signaling centers and is regulated by Wnt and activin during tooth organogenesis. Dev Biol 229(2):443-55. [PubMed: 11203701] [MGI Ref ID J:67054]
Laurikkala J; Pispa J; Jung HS; Nieminen P; Mikkola M; Wang X; Saarialho-Kere U; Galceran J; Grosschedl R; Thesleff I. 2002. Regulation of hair follicle development by the TNF signal ectodysplasin and its receptor Edar. Development 129(10):2541-53. [PubMed: 11973284] [MGI Ref ID J:75943]
Le Goascogne C; Eychenne B; Tonon MC; Lachapelle F; Baumann N; Robel P. 2000. Neurosteroid progesterone is up-regulated in the brain of jimpy and shiverer mice. Glia 29(1):14-24. [PubMed: 10594919] [MGI Ref ID J:78788]
Le Goascogne C; Sannanes N; Gouezou M; Baulieu EE; Robel P. 1993. Suppressed expression of the cytochrome P45017 alpha protein in the testicular feminized (Tfm) mouse testes. J Endocrinol 139(1):127-30. [PubMed: 8254285] [MGI Ref ID J:15718]
Lyon MF. 1963. Attempts to test the inactive-X theory of dosage compensation in mammals Genet Res 4:93-103. [MGI Ref ID J:272]
Lyon MF. 1970. Genetic activity of sex chromosomes in somatic cells of mammals. Philos Trans R Soc Lond B Biol Sci 259(828):41-52. [PubMed: 4399067] [MGI Ref ID J:5238]
Mayer TC; Green MC. 1978. Epidermis is the site of action of tabby (Ta) in the mouse. Genetics 90(1):125-31. [PubMed: 359407] [MGI Ref ID J:6041]
Miard S; Peterkova R; Vonesch JL; Peterka M; Ruch JV; Lesot H. 1999. Alterations in the incisor development in the Tabby mouse. Int J Dev Biol 43(6):517-29. [PubMed: 10610025] [MGI Ref ID J:104871]
Mou C; Jackson B; Schneider P; Overbeek PA; Headon DJ. 2006. Generation of the primary hair follicle pattern. Proc Natl Acad Sci U S A 103(24):9075-80. [PubMed: 16769906] [MGI Ref ID J:111052]
Mustonen T; Ilmonen M; Pummila M; Kangas AT; Laurikkala J; Jaatinen R; Pispa J; Gaide O; Schneider P; Thesleff I; Mikkola ML. 2004. Ectodysplasin A1 promotes placodal cell fate during early morphogenesis of ectodermal appendages. Development 131(20):4907-19. [PubMed: 15371307] [MGI Ref ID J:128256]
Narhi K; Jarvinen E; Birchmeier W; Taketo MM; Mikkola ML; Thesleff I. 2008. Sustained epithelial {beta}-catenin activity induces precocious hair development but disrupts hair follicle down-growth and hair shaft formation. Development 135(6):1019-28. [PubMed: 18256193] [MGI Ref ID J:131961]
Pennycuik PR; Raphael KA. 1984. The tabby locus (Ta) in the mouse: its site of action in tail and body skin. Genet Res 43(1):51-63. [PubMed: 6373499] [MGI Ref ID J:7450]
Peterkova R; Kristenova P; Lesot H; Lisi S; Vonesch JL; Gendrault JL; Peterka M. 2002. Different morphotypes of the tabby (EDA) dentition in the mouse mandible result from a defect in the mesio-distal segmentation of dental epithelium. Orthod Craniofac Res 5(4):215-26. [PubMed: 12416536] [MGI Ref ID J:103893]
Peterkova R; Lesot H; Viriot L; Peterka M. 2005. The supernumerary cheek tooth in tabby/EDA mice-a reminiscence of the premolar in mouse ancestors. Arch Oral Biol 50(2):219-25. [PubMed: 15721153] [MGI Ref ID J:98533]
Pispa J; Jung HS; Jernvall J; Kettunen P; Mustonen T; Tabata MJ; Kere J; Thesleff I. 1999. Cusp patterning defect in Tabby mouse teeth and its partial rescue by FGF. Dev Biol 216(2):521-34. [PubMed: 10642790] [MGI Ref ID J:59068]
Pispa J; Pummila M; Barker PA; Thesleff I; Mikkola ML. 2008. Edar and Troy signalling pathways act redundantly to regulate initiation of hair follicle development. Hum Mol Genet 17(21):3380-91. [PubMed: 18689798] [MGI Ref ID J:140329]
Probst FJ; Cooper ML; Cheung SW; Justice MJ. 2008. Genotype, phenotype, and karyotype correlation in the XO mouse model of Turner Syndrome. J Hered 99(5):512-7. [PubMed: 18499648] [MGI Ref ID J:138994]
Rao MS; Jaszczak E; Landis SC. 1994. Innervation of footpads of normal and mutant mice lacking sweat glands. J Comp Neurol 346(4):613-25. [PubMed: 7983247] [MGI Ref ID J:19910]
Rawlins EL; Hogan BL. 2005. Intercellular growth factor signaling and the development of mouse tracheal submucosal glands. Dev Dyn 233(4):1378-85. [PubMed: 15973734] [MGI Ref ID J:119848]
Risnes S; Peterkova R; Lesot H. 2005. Distribution and structure of dental enamel in incisors of Tabby mice. Arch Oral Biol 50(2):181-4. [PubMed: 15721148] [MGI Ref ID J:100300]
Schmidt-Ullrich R; Tobin DJ; Lenhard D; Schneider P; Paus R; Scheidereit C. 2006. NF-{kappa}B transmits Eda A1/EdaR signalling to activate Shh and cyclin D1 expression, and controls post-initiation hair placode down growth. Development 133(6):1045-57. [PubMed: 16481354] [MGI Ref ID J:106549]
Sofaer JA. 1969. Aspects of the tabby-crinkled-downless syndrome. I. The development of tabby teeth. J Embryol Exp Morphol 22(2):181-205. [PubMed: 5361554] [MGI Ref ID J:5138]
Sofaer JA. 1969. Aspects of the tabby-crinkled-downless syndrome. II. Observations on the reaction to changes of genetic background. J Embryol Exp Morphol 22(2):207-27. [PubMed: 5361555] [MGI Ref ID J:5139]
Sofaer JA. 1974. Differences between tabby and downless mouse epidermis and dermis in culture. Genet Res 23(2):219-25. [PubMed: 4420168] [MGI Ref ID J:5489]
Sofaer JA; MacLean CJ. 1970. Dominance in threshold characters. A comparison of two tabby alleles in the mouse. Genetics 64(2):273-80. [PubMed: 5470481] [MGI Ref ID J:5176]
Srivastava AK; Durmowicz MC; Hartung AJ; Hudson J; Ouzts LV; Donovan DM; Cui CY; Schlessinger D. 2001. Ectodysplasin-A1 is sufficient to rescue both hair growth and sweat glands in Tabby mice. Hum Mol Genet 10(26):2973-81. [PubMed: 11751679] [MGI Ref ID J:73715]
Srivastava AK; Pispa J; Hartung AJ; Du Y; Ezer S; Jenks T; Shimada T; Pekkanen M; Mikkola ML; Ko MS; Thesleff I; Kere J; Schlessinger D. 1997. The Tabby phenotype is caused by mutation in a mouse homologue of the EDA gene that reveals novel mouse and human exons and encodes a protein (ectodysplasin-A) with collagenous domains. Proc Natl Acad Sci U S A 94(24):13069-74. [PubMed: 9371801] [MGI Ref ID J:44605]
Sundberg JP (ed.). 1994. . In: Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. CRC Press, Boca Raton. [MGI Ref ID J:30359]
Toda I; Sullivan BD; Wickham LA; Sullivan DA. 1999. Gender- and androgen-related influence on the expression of proto-oncogene and apoptotic factor mRNAs in lacrimal glands of autoimmune and non-autoimmune mice. J Steroid Biochem Mol Biol 71(1-2):49-61. [PubMed: 10619357] [MGI Ref ID J:58967]
Tucker AS; Headon DJ; Courtney JM; Overbeek P; Sharpe PT. 2004. The activation level of the TNF family receptor, Edar, determines cusp number and tooth number during tooth development. Dev Biol 268(1):185-94. [PubMed: 15031115] [MGI Ref ID J:92196]
Vargas GA; Fantino E; George-Nascimento C; Gargus JJ; Haigler HT. 1996. Reduced epidermal growth factor receptor expression in hypohidrotic ectodermal dysplasia and Tabby mice. J Clin Invest 97(11):2426-32. [PubMed: 8647934] [MGI Ref ID J:33361]
Vielkind U; Hardy MH. 1996. Changing patterns of cell adhesion molecules during mouse pelage hair follicle development. 2. Follicle morphogenesis in the hair mutants, Tabby and downy. Acta Anat (Basel) 157(3):183-94. [PubMed: 9226037] [MGI Ref ID J:41386]
Yamago G; Takata Y; Furuta I; Urase K; Momoi T; Huh N. 2001. Suppression of hair follicle development inhibits induction of sonic hedgehog, patched, and patched-2 in hair germs in mice. Arch Dermatol Res 293(9):435-41. [PubMed: 11758785] [MGI Ref ID J:116953]
Health & husbandry
Health & Colony Maintenance Information
Colony Maintenance
Breeding & Husbandry The T(X;16)16H translocation chromosome (abbreviated T16H) is maintained in repulsion with EdaTa. T16H +/+ EdaTa females are bred to + EdaTa/Y males from the colony, which yields T16H +/Y and + EdaTa/Y males and T16H +/+ EdaTa and + EdaTa/EdaTa females. In the past, hybrid vigor was refreshed every few generations by crossing T16H +/+ EdaTa females to (C57BL/6J x CBA/J)F1 males; however, this has proven unnecessary and has been discontinued. Male mice having the T(X;16)16H translocation are sterile.
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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*Price(s) in US dollars ($)
Weeks of Age Price* Gender Cryorecovery Fee $1900.00
Additional Supply Details
| Pricing for International shipping destinations |
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*Price(s) in US dollars ($)
Weeks of Age Price* Gender Cryorecovery Fee $2470.00
Additional Supply Details
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
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| Supply Notes |
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General Terms and Conditions
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