Strain Name: |
STOCK T(2;11)30H/+ x AEJ-a Gdf5bp-H/J or A/J-a Gdf5bp-J/J |
|---|---|
Stock Number: |
000596 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Former Name |
T30H (Changed: 15-DEC-04
) |
| Genes & Alleles | Gdf5; Gdf5bp-H; Gdf5bp-J; a; T(2;11)30H; ; |
Product Information
Strain Details
Type Chromosome Aberration Additional information on Mice with Chromosomal Aberrations. Type JAX® GEMM® Strain - Mutant Stock Additional information on JAX® GEMM® Strains. Type Translocation Additional information on Mice with Chromosomal Aberrations. Species laboratory mouse
Gene & Allele Details
| Allele Symbol | Gdf5bp-H | ||
|---|---|---|---|
| Allele Name | brachypodism Harwell | ||
| Strain of Origin | PCT | ||
| Gene Symbol and Name | Gdf5, growth differentiation factor 5 | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | BMP14; CDMP-1; CDMP1; LAP4; SYNS2; bp; brachypod Japan; brachypodism; brp; cartilage-derived morphogenetic protein-1; | ||
| General Note | This remutation arose spontaneously at Harwell in the PCT multiple recessive stock (J:13391). It is essentially identical in effect with Gdf5bp, and has been used extensively in studies of brachypodism. Dissociated mesoderm cells from 12-day hindlimb buds of Gdfbp-H homozygous mutant embryos make fewer and smaller condensations than those of control embryos and chondrogenesis is delayed (J:12041). Cells of the limb mesenchyme are more adhesive than in normal embryos (J:6104). Cell aggregation and cartilaginous nodule formation were determined in cultures of various combinations of cells from different stages and parts of limb buds of 10- to 13-day embryos. In limb buds from mice homozygous for Gdf5bp-H, there is reduced ability of a specific mesenchyme cell population to provide inductive stimulus for chondrogenesis. This cell-cell interaction results in a lower proportion of chondrogenic cells and a higher proportion of more mature non-chondrogenic cells. A factor produced by the femur and fibula or by the postaxial part of the hindlimb bud of 13-day Gdf5bp-H homozygous mutant mice inhibits the growth in vitro of tibias of 13-day wild typeembryos (J:5444). Although tibias from 13-day mutant embryos grow normally in standard cultures, addition of a factor from the postaxial part of limb buds from 11- to 12-day wild type mice causes reduces growth of mutant but not of wild type 13-day tibias (J:11997). In an in vitro system which supports autonomous development of individual limb elements, the proximal-to-distal increase of severity of cartilage reduction is intensified in explants from homozygous mutant mice. (J:942). | ||
| Allele Symbol | Gdf5bp-J | ||
| Allele Name | brachypodism Jackson | ||
| Common Name(s) | GdfbpJ; | ||
| Strain of Origin | A/J | ||
| Gene Symbol and Name | Gdf5, growth differentiation factor 5 | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | BMP14; CDMP-1; CDMP1; LAP4; SYNS2; bp; brachypod Japan; brachypodism; brp; cartilage-derived morphogenetic protein-1; | ||
| General Note | The long bones of the limbs of mutant mice are slightly shorter than controls, and the fibula is shortened proximally. The bones of the axial skeleton are unaffected. | ||
| Molecular Note | This remutation to brachypodism occurred in the A/J strain at The Jackson Laboratory. The mutation is caused by the insertion of a guanine residue into a stretch of three guanine residues in the gene sequence (position 1444-1448), producing a stop codon 41 amino acids later. [MGI Ref ID J:17582] | ||
| Allele Symbol | a | ||
| Allele Name | nonagouti | ||
| Gene Symbol and Name | T(2;11)30H, reciprocal translocation, Chr 2 and 11, Harwell 30 | ||
| Chromosome | 11 | ||
| Gene Common Name(s) | T30H; | ||
Related Strains
Reciprocal Translocations
View Reciprocal Translocations (47 strains)
000251 AEJ.Cg-ae +/a Gdf5bp-H/J
Research Applications
This mouse can be used to support research in many areas including:
Gdf5bp-H relatedResearch Tools
Genetics Research
Gdf5bp-J relatedDevelopmental Biology Research
Growth Defects
Mouse/Human Gene Homologs
acromesomelic dysplasia, Hunter-Thompson Type
Developmental Biology Research
Growth Defects
Mouse/Human Gene Homologs
acromesomelic dysplasia, Hunter-Thompson Type
References
Additional ReferencesPrice and Supply Information
| Strain Name: | STOCK T(2;11)30H/+ x AEJ-a Gdf5bp-H/J or A/J-a Gdf5bp-J/J |
| Stock Number: | 000596 |
Price Details
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery of Strains Needing Progeny Testing. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two untested males and two untested females (two pairs) will be recovered, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the overall recovery time to approximately 25 weeks. However, all pups recovered will be sent. Progeny testing is required to identify the genotype of mice of this strain, as a genotyping assay is not available. This type of testing involves breeding the recovered animals and assessing the phenotype of the offspring in order to identify animals carrying the mutation of interest. We can perform the progeny testing for you as a service or we can ship all recovered animals (at least two untested pairs) to you for progeny testing at your facility. If you perform the progeny testing, there is NO guarantee that a carrier will be identified. If we perform progeny testing as a service, additional breeding time will be required. In this case, when a male and female (one pair) are identified that carry the mutation, they and their offspring will be shipped. Delivery time for strains requiring progeny testing often exceeds 25 weeks and may take 12 months or more due to the difficulties in breeding some strains. The progeny testing cost is in addition to the recovery cost and is based on the number of boxes used and the time taken to produce the mice identified as carrying the mutation. Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Please contact Customer Service for more information on the cost of progeny testing for a strain: Tel: 1-800-422-6423 or 1-207-288-5845. Cryorecovery to establish a Dedicated Supply for greater quantities of mice |
| Licensing | See General Terms and Conditions below |
General Terms and Conditions
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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