| |||||||||||
- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Former Names T30H (Changed: 15-DEC-04 ) Type Chromosome Aberration; Translocation; Additional information on Mice with Chromosomal Aberrations. Type Mutant Stock; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse
Related Strains
Reciprocal Translocations
View Reciprocal Translocations (46 strains)
000251 AEJ.Cg-ae +/a Gdf5bp-H/J
002239 B6 x BALB/cJ-Gdf5bp-3J/J
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
Gdf5bp-H relatedResearch Tools
Genetics Research
Gdf5bp-J relatedDevelopmental Biology Research
Growth Defects
Mouse/Human Gene Homologs
acromesomelic dysplasia, Hunter-Thompson Type
Developmental Biology Research
Growth Defects
Mouse/Human Gene Homologs
acromesomelic dysplasia, Hunter-Thompson Type
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Gdf5bp-H | ||
|---|---|---|---|
| Allele Name | brachypodism Harwell | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | PCT | ||
| Gene Symbol and Name | Gdf5, growth differentiation factor 5 | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | BMP14; CDMP-1; CDMP1; LAP4; OS5; SYNS2; bp; brachypod Japan; brachypodism; brp; cartilage-derived morphogenetic protein-1; | ||
| General Note | This remutation arose spontaneously at Harwell in the PCT multiple recessive stock (J:13391). It is essentially identical in effect with Gdf5bp, and has been used extensively in studies of brachypodism. Dissociated mesoderm cells from 12-day hindlimb buds of Gdfbp-H homozygous mutant embryos make fewer and smaller condensations than those of control embryos and chondrogenesis is delayed (J:12041). Cells of the limb mesenchyme are more adhesive than in normal embryos (J:6104). Cell aggregation and cartilaginous nodule formation were determined in cultures of various combinations of cells from different stages and parts of limb buds of 10- to 13-day embryos. In limb buds from mice homozygous for Gdf5bp-H, there is reduced ability of a specific mesenchyme cell population to provide inductive stimulus for chondrogenesis. This cell-cell interaction results in a lower proportion of chondrogenic cells and a higher proportion of more mature non-chondrogenic cells. A factor produced by the femur and fibula or by the postaxial part of the hindlimb bud of 13-day Gdf5bp-H homozygous mutant mice inhibits the growth in vitro of tibias of 13-day wild-typeembryos (J:5444). Although tibias from 13-day mutant embryos grow normally in standard cultures, addition of a factor from the postaxial part of limb buds from 11- to 12-day wild-type mice causes reduces growth of mutant but not of wild-type 13-day tibias (J:11997). In an in vitro system which supports autonomous development of individual limb elements, the proximal-to-distal increase of severity of cartilage reduction is intensified in explants from homozygous mutant mice. (J:942). | ||
| Allele Symbol | Gdf5bp-J | ||
| Allele Name | brachypodism Jackson | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | GdfbpJ; | ||
| Strain of Origin | A/J | ||
| Gene Symbol and Name | Gdf5, growth differentiation factor 5 | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | BMP14; CDMP-1; CDMP1; LAP4; OS5; SYNS2; bp; brachypod Japan; brachypodism; brp; cartilage-derived morphogenetic protein-1; | ||
| General Note | The long bones of the limbs of mutant mice are slightly shorter than controls, and the fibula is shortened proximally. The bones of the axial skeleton are unaffected. | ||
| Molecular Note | This remutation to brachypodism occurred in the A/J strain at The Jackson Laboratory. The mutation is caused by the insertion of a guanine residue into a stretch of three guanine residues in the gene sequence (position 1444-1448), producing a stop codon 41 amino acids later. [MGI Ref ID J:17582] | ||
| Allele Symbol | a | ||
| Allele Name | nonagouti | ||
| Allele Type | Spontaneous | ||
| Gene Symbol and Name | T(2;11)30H, reciprocal translocation, Chr 2 and 11, Harwell 30 | ||
| Chromosome | 11 | ||
| Gene Common Name(s) | T30H; | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
References
References
Additional References
Gdf5bp-H relatedGdf5bp-J relatedBugrilova RS; Konyukhov BV. 1978. Regulator of the expression of the gene brachypodism-H in the mouse. Sov Genet 14:1272-1278. [MGI Ref ID J:11997]
Duke J; Elmer WA. 1978. Cell adhesion and chondrogenesis in brachypod mouse limb mesenchyme: fragment fusion studies. J Embryol Exp Morphol 48:161-8. [PubMed: 744946] [MGI Ref ID J:6104]
Duke J; Elmer WA. 1977. Effect of the brachypod mutation on cell adhesion and chondrogenesis in aggregates of mouse limb mesenchyme. J Embryol Exp Morphol 42:209-217. [MGI Ref ID J:12041]
Kwasigroch TE; Curtis SK; Knudsen TB; Barrach HJ; Elmer WA. 1992. Morphological analysis of abnormal digital chondrogenesis in the brachypod (bpH) mouse limb in organ culture. Anat Embryol (Berl) 185(4):307-15. [PubMed: 1609959] [MGI Ref ID J:942]
Lyon MF. 1958. brachypody, bp Mouse News Lett 19:22. [MGI Ref ID J:13391]
Owens EM; Solursh M. 1983. Accelerated maturation of limb mesenchyme by the BrachypodH mouse mutation. Differentiation 24(2):145-8. [PubMed: 6309591] [MGI Ref ID J:7163]
Owens EM; Solursh M. 1982. Cell-cell interaction by mouse limb cells during in vitro chondrogenesis: analysis of the brachypod mutation. Dev Biol 91(2):376-88. [PubMed: 7095270] [MGI Ref ID J:6808]
Pleskova MV; Rodionov VM; Bugrilova RS; Konyukhov BV. 1974. The partial purification of growth-inhibiting factor of the brachypodism-H mouse embryos. Dev Biol 37(2):417-21. [PubMed: 4826284] [MGI Ref ID J:5444]
Baur ST; Mai JJ; Dymecki SM. 2000. Combinatorial signaling through BMP receptor IB and GDF5: shaping of the distal mouse limb and the genetics of distal limb diversity. Development 127(3):605-19. [PubMed: 10631181] [MGI Ref ID J:59288]
Clark RT; Johnson TL; Schalet BJ; Davis L; Gaschen V; Hunziker EB; Oldberg A; Mikic B. 2001. GDF-5 deficiency in mice leads to disruption of tail tendon form and function. Connect Tissue Res 42(3):175-86. [PubMed: 11913489] [MGI Ref ID J:117311]
Kanauchi Y; Takahara M; Harada M; Ogino T. 2008. Growth of severely hypoplastic phalanges and metacarpals in symbrachydactyly: an experimental study in mice. J Hand Surg [Am] 33(9):1589-96. [PubMed: 18984342] [MGI Ref ID J:143089]
Mikic B; Battaglia TC; Taylor EA; Clark RT. 2002. The effect of growth/differentiation factor-5 deficiency on femoral composition and mechanical behavior in mice. Bone 30(5):733-7. [PubMed: 11996912] [MGI Ref ID J:109392]
Mikic B; Schalet BJ; Clark RT; Gaschen V; Hunziker EB. 2001. GDF-5 deficiency in mice alters the ultrastructure, mechanical properties and composition of the Achilles tendon. J Orthop Res 19(3):365-71. [PubMed: 11398847] [MGI Ref ID J:113154]
Settle SH Jr; Rountree RB; Sinha A; Thacker A; Higgins K; Kingsley DM. 2003. Multiple joint and skeletal patterning defects caused by single and double mutations in the mouse Gdf6 and Gdf5 genes. Dev Biol 254(1):116-30. [PubMed: 12606286] [MGI Ref ID J:83132]
Storm EE; Huynh TV; Copeland NG; Jenkins NA; Kingsley DM; Lee SJ. 1994. Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily [see comments] Nature 368(6472):639-43. [PubMed: 8145850] [MGI Ref ID J:17582]
Storm EE; Kingsley DM. 1996. Joint patterning defects caused by single and double mutations in members of the bone morphogenetic protein (BMP) family. Development 122(12):3969-79. [PubMed: 9012517] [MGI Ref ID J:38423]
Takahara M; Harada M; Guan D; Otsuji M; Naruse T; Takagi M; Ogino T. 2004. Developmental failure of phalanges in the absence of growth/differentiation factor 5. Bone 35(5):1069-76. [PubMed: 15542031] [MGI Ref ID J:94510]
Yi SE; Daluiski A; Pederson R; Rosen V; Lyons KM. 2000. The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb. Development 127(3):621-30. [PubMed: 10631182] [MGI Ref ID J:59282]
Health & husbandry
Health & Colony Maintenance Information
Currently there no information available for this strain. This may be due to the supply level of this strain.
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
|
Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
| Pricing for International shipping destinations |
|
Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
|
|
|
Supply Details
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
|
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
Purchasing Information
JAX® Mice Orders
Surgical Services
Contact Information
Orders & Technical Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form
Terms of Use
Terms of Use
General Terms and Conditions
Contact information
General inquiries
Contracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. In purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.