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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Former Names B6C3H-a/A-T(10;13)199H +/+ Lystbg-J or Lystbg-2J (Changed: 15-DEC-04 ) B6C3H-a/A-T199H +/+ Lystbg-J or Lystbg-2J (Changed: 15-DEC-04 ) T199H (Changed: 15-DEC-04 ) Type Chromosome Aberration; Translocation; Additional information on Mice with Chromosomal Aberrations. Type Mutant Stock; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation +N2
Related Strains
Reciprocal Translocations
View Reciprocal Translocations (46 strains)
003301 (C57BL/6J x C3H-Eya1bor)F1/J 002083 B6 x B6EiC3 a/A-T(7;16)235Dn/J 000507 B6 x B6EiC3 a/A-Otcspf/J 000628 B6.CE-A Amy1b Amy2a5b/J 004200 B6;CBACa Aw-J/A-Npr2cn-2J/GrsrJ 001752 B6CBCa Aw-J/A-T(7;15)9H/J 006450 B6EiC3 a/A-Vss/GrsrJ 000557 B6EiC3-+ a/LnpUl A/J 000504 B6EiC3Sn a/A-Cacnb4lh/J 000553 B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J 001811 B6EiC3Sn a/A-Otcspf-ash/J 002343 B6EiC3Sn a/A-Otcspf/J 001923 B6EiC3Sn a/A-Ts(417)2Lws TimT(4;17)3Lws/J 000200 C3FeB6 A/Aw-J-Ankank/J 000638 C3FeB6 A/Aw-J-Spnb4qv-J/J 000283 LT.CAST-A/J 001759 STOCK A Tyrc Sha/J
000509 C3.Cg-Lystbg-2J/J
000629 C57BL/6J-Lystbg-J/J
000204 B6.C3Rl-Lystbg/J 000494 J.Cg-Oca2+ Tyr+ Lystbg/J 000269 SB/LeJ
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:Lystbg-2J related
Lystbg-J relatedCardiovascular Research
Atherosclerosis
Dermatology Research
Color and White Spotting Defects
Hematological Research
Immunological Defects
Platelet Defects
platelet storage pool deficiency
Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunodeficiency
Intracellular Signaling Molecules
Internal/Organ Research
Kidney Defects
lysosomal enzyme abnormalities
Metabolism Research
Mouse/Human Gene Homologs
Chediak-Higashi syndrome
Research Tools
Immunology and Inflammation Research
NK Cell Deficiency
Cardiovascular Research
Atherosclerosis
Dermatology Research
Color and White Spotting Defects
Hematological Research
Immunological Defects
Platelet Defects
platelet storage pool deficiency
Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunodeficiency
NK Cell and Cd8 T Cell defects
Immunodeficiency Associated with Other Defects
Intracellular Signaling Molecules
Internal/Organ Research
Kidney Defects
lysosomal enzyme abnormalities
Metabolism Research
Mouse/Human Gene Homologs
Chediak-Higashi syndrome
Research Tools
Immunology and Inflammation Research
NK Cell Deficiency
Genes & Alleles
Gene & Allele Information
| Allele Symbol | A | ||
|---|---|---|---|
| Allele Name | wild type agouti | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | dark-bellied agouti; | ||
| Strain of Origin | various | ||
| Gene Symbol and Name | a, nonagouti | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | AGSW; AGTI; AGTIL; ASP; As; MGC126092; MGC126093; SHEP9; agouti; agouti signal protein; agouti suppressor; | ||
| General Note | The A allele is usually regarded as a wild-type allele. Hairs are black with a subapical yellow band. This black-yellow-black pattern is referred to as agouti. The general appearance is yellowish brown, slightly lighter on the belly than on the back. | ||
| Molecular Note | This allele, often referred to as wild-type, comprises a novel 131 amino acid protein encoded in a gene comprising four exons, three coding, spanning 18kb. Unique changes in this gene account for all other alleles that have been molecularly characterized. The expression of this allele is almost always dominant to other alleles of this gene. [MGI Ref ID J:3523] | ||
| Allele Symbol | Lystbg-2J | ||
| Allele Name | beige 2 Jackson | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | Yellow stock | ||
| Gene Symbol and Name | Lyst, lysosomal trafficking regulator | ||
| Chromosome | 13 | ||
| Gene Common Name(s) | Beige; CHS; CHS1; D13Sfk13; DNA segment, Chr 13, Stephen F. Kingsmore 13; beige; bg; | ||
| Molecular Note | This allele was identified by a noncomplementation test with Lystbg. Quantitative reverse transcription showed the molecular fault in the Lystbg-2J mutation may be an intronic retrotransposition event causing a five-fold decrease intranscription and mRNA instability. [MGI Ref ID J:34205] | ||
| Allele Symbol | Lystbg-J | ||
| Allele Name | beige Jackson | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | bgj; | ||
| Strain of Origin | C57BL/6J | ||
| Gene Symbol and Name | Lyst, lysosomal trafficking regulator | ||
| Chromosome | 13 | ||
| Gene Common Name(s) | Beige; CHS; CHS1; D13Sfk13; DNA segment, Chr 13, Stephen F. Kingsmore 13; beige; bg; | ||
| Molecular Note | This allele is defined by a noncomplementation test with Lystbg. Although mice homozygous for this allele show a decrease in Lyst mRNA in the liver compared to normal, the molecular basis for this allele is not yet known. [MGI Ref ID J:7539] | ||
| Allele Symbol | a | ||
| Allele Name | nonagouti | ||
| Allele Type | Spontaneous | ||
| Gene Symbol and Name | T(10;13)199H, reciprocal translocation, Chr 10 and 13, Harwell 199 | ||
| Chromosome | 13 | ||
| Gene Common Name(s) | T199H; | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
References
References
Additional References
A relatedLystbg-2J relatedBlewitt ME; Vickaryous NK; Hemley SJ; Ashe A; Bruxner TJ; Preis JI; Arkell R; Whitelaw E. 2005. An N-ethyl-N-nitrosourea screen for genes involved in variegation in the mouse. Proc Natl Acad Sci U S A 102(21):7629-34. [PubMed: 15890782] [MGI Ref ID J:99816]
Bultman SJ; Michaud EJ; Woychik RP. 1992. Molecular characterization of the mouse agouti locus. Cell 71(7):1195-204. [PubMed: 1473152] [MGI Ref ID J:3523]
Bundschuh VG; Madry M. 1988. [atwp mutation in an albino mouse substrain (AB/Hum-1)] Z Versuchstierkd 31(6):249-54. [PubMed: 3227730] [MGI Ref ID J:16568]
Czyzyk TA; Sikorski MA; Yang L; McKnight GS. 2008. Disruption of the RIIbeta subunit of PKA reverses the obesity syndrome of Agouti lethal yellow mice. Proc Natl Acad Sci U S A 105(1):276-81. [PubMed: 18172198] [MGI Ref ID J:131039]
Dickie MM. 1969. Mutations at the agouti locus in the mouse. J Hered 60(1):20-5. [PubMed: 5798139] [MGI Ref ID J:30922]
Dry FW. 1928. The agouti coloration of the mouse (Mus Musculus) and the rat (Mus Norvegicus). J Genet 20:131-144. [MGI Ref ID J:46318]
Guido V, and The Mouse Mutant Resource (MMR) at The Jackson Laboratory. 2002. Two new mutations of white bellied agouti, w-46J and w-47J MGI Direct Data Submission :. [MGI Ref ID J:77218]
Jackson IJ; Budd PS; Keighren M; McKie L. 2007. Humanized MC1R transgenic mice reveal human specific receptor function. Hum Mol Genet 16(19):2341-8. [PubMed: 17652101] [MGI Ref ID J:129904]
Mather K; North SB. 1940. Umbrous: a case of dominance modification in mice. J Genet 40:229-41. [MGI Ref ID J:280]
Perry WL; Copeland NG; Jenkins NA. 1994. The molecular basis for dominant yellow agouti coat color mutations. Bioessays 16(10):705-7. [PubMed: 7980472] [MGI Ref ID J:21244]
Quevedo WC Jr.; Chase HB. 1958. An analysis of the light mutation of coat color in mice. J Morphol 102:329-345. [MGI Ref ID J:13094]
Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York. [MGI Ref ID J:78801]
Lystbg-J relatedBarbosa MD; Nguyen QA; Tchernev VT; Ashley JA; Detter JC; Blaydes SM; Brandt SJ; Chotai D; Hodgman C; Solari RC; Lovett M; Kingsmore SF. 1996. Identification of the homologous beige and Chediak-Higashi syndrome genes. Nature 382(6588):262-5. [PubMed: 8717042] [MGI Ref ID J:34205]
Jadeski L; Hoffman-Goetz L. 1996. Exercise and in vivo natural cytotoxicity against tumour cells of varying metastatic capacity. Clin Exp Metastasis 14(2):138-44. [PubMed: 8605727] [MGI Ref ID J:33522]
Lane PW. 1962. bg-beige and bg<2J> - beige-2J Mouse News Lett 26:35. [MGI Ref ID J:65327]
Marquis G; Montplaisir S; Pelletier M; Mousseau S; Auger P. 1985. Genetic resistance to murine cryptococcosis: the beige mutation (Chediak-Higashi syndrome) in mice. Infect Immun 47(1):288-93. [PubMed: 3965401] [MGI Ref ID J:147940]
Murphy ED; Roths JB. 1978. Purkinje cell degeneration, a late effect of beige mutations in mice Jackson Lab Ann Rep 49:108-9. [MGI Ref ID J:15166]
Anderson MG; Hawes NL; Trantow CM; Chang B; John SW. 2008. Iris phenotypes and pigment dispersion caused by genes influencing pigmentation. Pigment Cell Melanoma Res 21(5):565-78. [PubMed: 18715234] [MGI Ref ID J:141035]
Barbosa MD; Nguyen QA; Tchernev VT; Ashley JA; Detter JC; Blaydes SM; Brandt SJ; Chotai D; Hodgman C; Solari RC; Lovett M; Kingsmore SF. 1996. Identification of the homologous beige and Chediak-Higashi syndrome genes. Nature 382(6588):262-5. [PubMed: 8717042] [MGI Ref ID J:34205]
Bumgardner GL; Gao D; Li J; Baskin JH; Heininger M; Orosz CG. 2000. Rejection responses to allogeneic hepatocytes by reconstituted SCID mice, CD4, KO, and CD8 KO mice. Transplantation 70(12):1771-80. [PubMed: 11152110] [MGI Ref ID J:66571]
Bussiere JL; Adler MW; Rogers TJ; Eisenstein TK. 1993. Effects of in vivo morphine treatment on antibody responses in C57BL/6 bgJ/bgJ (beige) mice. Life Sci 52(4):PL43-8. [PubMed: 8421432] [MGI Ref ID J:4023]
Carlson GA; Marshall ST; Truesdale AT. 1984. Adaptive immune defects and delayed rejection of allogeneic tumor cells in beige mice. Cell Immunol 87(2):348-56. [PubMed: 6467382] [MGI Ref ID J:7539]
Chiang EY; Stroynowski I. 2004. A nonclassical MHC class I molecule restricts CTL-mediated rejection of a syngeneic melanoma tumor. J Immunol 173(7):4394-401. [PubMed: 15383569] [MGI Ref ID J:93729]
Christianson SW; Greiner DL; Schweitzer IB; Gott B; Beamer GL; Schweitzer PA; Hesselton RM; Shultz LD. 1996. Role of natural killer cells on engraftment of human lymphoid cells and on metastasis of human T-lymphoblastoid leukemia cells in C57BL/6J-scid mice and in C57BL/6J-scid bg mice. Cell Immunol 171(2):186-99. [PubMed: 8806787] [MGI Ref ID J:34814]
Davis SG; Lyerla TA. 1997. The effect of lysosomotropic amines on beige mouse cells. Exp Cell Res 237(1):242-5. [PubMed: 9417888] [MGI Ref ID J:44747]
Dove WF; Clipson L; Gould KA; Luongo C; Marshall DJ; Moser AR; Newton MA; Jacoby RF. 1997. Intestinal neoplasia in the ApcMin mouse: independence from the microbial and natural killer (beige locus) status. Cancer Res 57(5):812-4. [PubMed: 9041176] [MGI Ref ID J:38777]
Gardi C; Cavarra E; Calzoni P; Marcolongo P; de Santi M; Martorana PA; Lungarella G. 1994. Neutrophil lysosomal dysfunctions in mutant C57 Bl/6J mice: interstrain variations in content of lysosomal elastase, cathepsin G and their inhibitors. Biochem J 299(Pt 1):237-45. [PubMed: 8166647] [MGI Ref ID J:17583]
Glass WG; Subbarao K; Murphy B; Murphy PM. 2004. Mechanisms of host defense following severe acute respiratory syndrome-coronavirus (SARS-CoV) pulmonary infection of mice. J Immunol 173(6):4030-9. [PubMed: 15356152] [MGI Ref ID J:92752]
Gross SK; Lyerla TA; Williams MA; McCluer RH. 1992. The accumulation and metabolism of glycosphingolipids in primary kidney cell cultures from beige mice. Mol Cell Biochem 118(1):61-6. [PubMed: 1488056] [MGI Ref ID J:21419]
Kveiborg M; Chiusaroli R; Sims NA; Wu M; Sabatakos G; Horne WC; Baron R. 2002. The increased bone mass in deltaFosB transgenic mice is independent of circulating leptin levels. Endocrinology 143(11):4304-9. [PubMed: 12399426] [MGI Ref ID J:80469]
Lane PW. 1962. bg-beige and bg<2J> - beige-2J Mouse News Lett 26:35. [MGI Ref ID J:65327]
Lane PW; Murphy ED. 1972. Susceptibility to spontaneous pneumonitis in an inbred strain of beige and satin mice. Genetics 72(3):451-60. [PubMed: 4643821] [MGI Ref ID J:5311]
Marquis G; Montplaisir S; Pelletier M; Auger P; Lapp WS. 1988. Genetics of resistance to infection with Candida albicans in mice. Br J Exp Pathol 69(5):651-60. [PubMed: 3058198] [MGI Ref ID J:27324]
Marquis G; Montplaisir S; Pelletier M; Mousseau S; Auger P. 1985. Genetic resistance to murine cryptococcosis: the beige mutation (Chediak-Higashi syndrome) in mice. Infect Immun 47(1):288-93. [PubMed: 3965401] [MGI Ref ID J:147940]
Murphy ED; Roths JB. 1978. Purkinje cell degeneration, a late effect of beige mutations in mice Jackson Lab Ann Rep 49:108-9. [MGI Ref ID J:15166]
Novak EK; Hui SW; Swank RT. 1984. Platelet storage pool deficiency in mouse pigment mutations associated with seven distinct genetic loci. Blood 63(3):536-44. [PubMed: 6696991] [MGI Ref ID J:7327]
Paigen B; Holmes PA; Novak EK; Swank RT. 1990. Analysis of atherosclerosis susceptibility in mice with genetic defects in platelet function. Arteriosclerosis 10(4):648-52. [PubMed: 2369371] [MGI Ref ID J:29748]
Pak MW; Giolli RA; Pinto LH; Mangini NJ; Gregory KM; Vanable JW Jr. 1987. Retinopretectal and accessory optic projections of normal mice and the OKN-defective mutant mice beige, beige-J, and pearl. J Comp Neurol 258(3):435-46. [PubMed: 3584547] [MGI Ref ID J:29747]
Percy DH; Barta JR. 1993. Spontaneous and experimental infections in scid and scid/beige mice. Lab Anim Sci 43(2):127-32. [PubMed: 8320959] [MGI Ref ID J:4752]
Perou CM; Leslie JD; Green W; Li L; Ward DM; Kaplan J. 1997. The Beige/Chediak-Higashi syndrome gene encodes a widely expressed cytosolic protein. J Biol Chem 272(47):29790-4. [PubMed: 9368050] [MGI Ref ID J:44170]
Petrovan RJ; Yuan Y; Curtiss LK. 2008. Expression of the Lystbeige mutation is atheroprotective in chow-fed apolipoprotein E-deficient mice. J Lipid Res 49(2):429-37. [PubMed: 17982137] [MGI Ref ID J:131876]
Prigent D; Trancart MM; Seed MP; Willoughby DA. 1996. Proteoglycan degrading activity in granulomatous inflammation: comparison between the C57b1/6 and C57bg/bg mouse. Inflamm Res 45(10):494-8. [PubMed: 8912013] [MGI Ref ID J:36682]
Schiller NK; Black AS; Bradshaw GP; Bonnet DJ; Curtiss LK. 2004. Participation of macrophages in atherosclerotic lesion morphology in LDLr-/- mice. J Lipid Res 45(8):1398-409. [PubMed: 15175354] [MGI Ref ID J:91367]
Schiller NK; Boisvert WA; Curtiss LK. 2002. Inflammation in atherosclerosis: lesion formation in LDL receptor-deficient mice with perforin and Lyst(beige) mutations. Arterioscler Thromb Vasc Biol 22(8):1341-6. [PubMed: 12171798] [MGI Ref ID J:103214]
Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York. [MGI Ref ID J:78801]
Health & husbandry
Health & Colony Maintenance Information
Currently there no information available for this strain. This may be due to the supply level of this strain.
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
| Pricing for International shipping destinations |
|
Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
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Supply Details
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
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| Supply Notes |
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Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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