Strain Name: |
B6 x FSB/GnEi a/a Ctslfs/J |
|---|---|
Stock Number: |
000618 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Genes & Alleles | Ctsl; Ctslfs; a; |
Type JAX® GEMM® Strain - Mutant Strain Additional information on JAX® GEMM® Strains. Species laboratory mouse Strain Development
The furless mutation (Ctslfs) appeared in an unpedigreed stock at Ohio State University in the early 1950s. It was brought to The Jackson Laboratory by Dr. E. L. Green in 1956. The stock was maintained by sibling matings with forced heterozygosis. The stock was called FSB. It was cryopreserved in 1984 by mating homozygous males, produced from an outcross to C57BL/6J and crossed back to the FSB stock, to C57BL/6J females.
Mammalian Phenotype Terms assigned by genotype |
| Allele Symbol | Ctslfs | ||
|---|---|---|---|
| Allele Name | furless | ||
| Strain of Origin | unpedigreed stock | ||
| Gene Symbol and Name | Ctsl, cathepsin L | ||
| Chromosome | 13 | ||
| Gene Common Name(s) | 1190035F06Rik; CATHL; CATL; Cat L; FLJ31037; MEP; RIKEN cDNA 1190035F06 gene; fs; furless; major excreted protein; nackt; nkt; | ||
| General Note | The phenotype of homozygous furless mice was notably similar to the phenotype observed in Ctsltm1Cptr homozygous mice. An allele test between the two mutant strains of mice was performed, where they failed to complement, indicating the two mutants are allelic. | ||
| Molecular Note | The mutation in the furless mutant was identified as a G to A transition in exon 5, resulting in an arginine to glycine substitution at position 149 of the protein. [MGI Ref ID J:70118] | ||
| Allele Symbol | a | ||
| Allele Name | nonagouti | ||
Strains carrying a allele
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Ctslfs related
Dermatology Research
Skin and Hair Texture Defects
Selected Reference(s)
Additional ReferencesRoth W; Deussing J; Botchkarev VA; Pauly-Evers M; Saftig P; Hafner A; Schmidt P; Schmahl W; Scherer J; Anton-Lamprecht I; Von Figura K; Paus R; Peters C. 2000. Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling. FASEB J 14(13):2075-86. [PubMed: 11023992] [MGI Ref ID J:70118]
| Strain Name: | B6 x FSB/GnEi a/a Ctslfs/J |
| Stock Number: | 000618 |
IMPORTANT NOTE: Prices are based on shipping destination. To view prices, select your shipping destination.
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below |
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