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- Description
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Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Former Names B6C3Fe a/a- anx/J (Changed: 15-DEC-04 ) B6C3Fe-a/a-anx (Changed: 15-DEC-04 ) Type Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation N28 F1
Generation DefinitionsAppearance
black, affected
Related Genotype: a anx/a anx
black, unaffected
Related Genotype: a ?/a +Description
Compared with their wildtype siblings, anx/anx homozygotes are characterized by a thinning in the neck and tail at 5 days of age, lower body weight detectable by 9 days of age, and death by 22 days of age on the B6C3H-a/a background. Outbreeding to CAST/Ei modifies the phenotype such that homozygotes live to approximately 5 weeks of age. Evaluation of stomach content shows that anx/anx mice ingest less than their siblings. They show headweaving, body tremors, uncoordinated gait, and hyperactivity along with diminished adipose tissue and reduced serum leptin levels. (Maltais et al., 1984; Johansen et al., 2000)Intraperitoneal injection of 20 day old pups with 5,7-dihydroxytryptamine, a seratonin antagonist, reduces the severity of the neurological phenotypes. Homozygotes have extensive serotonergic hyperinnervation in normal target fields including the hippocampus, frontal cortex, olfactory bulb, and cerebellum, yet they have normal catecholaminergic innervation. This hyperinnervation is thought to reflect increased arborization of axonal fibers since there is no increase in serotonergic cell bodies. In the raphe nuiclues, there are decreased mRNA levels of serotonin transp orter (Slc6a4 previously Htt or 5-Htt) and tryptophan hydroxylase activity is diminished. Similar to food deprived wild type mice, anx/anx mice show decreased mRNA of monoamine oxidase A in the locus ceruleus but not the raphe nuclei. (Maltais et al., 1984; Son et al., 1994; Jahng et al., 1998, Brain Res; Jahng et al., 1998, Dev Brain Res.)
Despite their failure to eat adequately, homozygotes do not show elevated neuropeptide Y mRNA levels in the hypothalamic arcuate nucleus. However, immunohistochemistry revealed increased perikaryal neuropeptide Y staining in the arcuate nucleus and decreased density and neuropeptide Y staining of neuropeptide Y terminals in the paraventricular, arcuate, and other hypothalamic nuclei. Neuropeptide Y staining in the suprachiasmatic and thalamic paraventricular nuclei is normal. There is a similarly altered pattern of expression for agouti gene-related protein with immunoreacitvity increased in the cell body and decreased in the terminals in arcuate neurons despite apparently normal mRNA levels. (Broberger et al., 1997; Jahng et al., 1998, Brain Res; Broberger at el., 1998)
The arcuate nucleus also has a reduction in the number of pro-opiomelanocortin expressing neurons, a reduction in mRNA levels of pro-opiomelanocor tin and neuropeptide Y receptors Y1 and Y5, and a reduction in immunoreactivity of neuropeptide Y receptor Y2, adrenocorticotropic hormone, and alpha melanocyte stimulating hormone. Decreased staining of aspartate, acetylcholinesterase, and somatostatin was also seen in the arcuate nucleus. Decreased staining of cocaine and amphetamine regulated transcript in the arcuate nucleus and other regions of the hyopthalamus has also been reported. This pattern of decreased staining of pro-opiomelanocortin neurons may be due to degeneration of this cell population. No changes in brain cholecystokinin, galanin, or serotonin were detected by immunohistochemistry. (Broberger et al., 1997; Broberger et al., 1999; Johansen et al., 2000.)
The dentate gyrus of anx/anx mice is smaller than normal and has an increase in both the number of proliferating cells and cells undergoing apoptosis according to BrdU and TUNEL assessment. (Kim et al., 2001.)
Control Information
| Control | ||
|---|---|---|
| Untyped from the colony | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying a allele
View Strains carrying a (103 strains)
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
anx/anx
B6C3Fe a/a-anx/J
- mortality/aging
- premature death
- mutant mice die in a state of anorexia and emaciation at ~P22 (MGI Ref ID J:7689)
- behavior/neurological phenotype
- abnormal eating behavior
- abnormal suckling behavior
- physiological and behavioral phenotypes appear to result from a suckling dysfunction (MGI Ref ID J:7689)
- abnormal gait
- abnormal head movements
- headweaving at P18 or later (MGI Ref ID J:7689)
- hyperactivity
- tremors
- growth/size phenotype
- decreased body weight
- significant reduction in body weight at P9 (MGI Ref ID J:7689)
- cachexia
- anorexic mutants are first recognized at ~P5 by a thinning of the neck and tail, and later by growth arrest and emaciation (MGI Ref ID J:7689)
- immune system phenotype
- abnormal inflammatory response (MGI Ref ID J:103396)
- increased thymus weight
- significant increase in thymus weight at P15 but not at P5 (MGI Ref ID J:7689)
- pale spleen
- small spleen
- beginning at ~P5, spleen size is reduced (MGI Ref ID J:7689)
- decreased spleen weight
- significant reduction in spleen weight both at P5 and at P15 (MGI Ref ID J:7689)
- homeostasis/metabolism phenotype
- decreased body temperature
- significant hypothermia at ~P22, but not at P5, P10 or P15 (MGI Ref ID J:7689)
- hypoglycemia
- significantly decreased blood glucose levels relative to wild-type littermates at P15 (58 mg/dl vs 129 mg/dl, respectively) (MGI Ref ID J:7689)
- increased blood urea nitrogen level
- significantly increased blood urea nitrogen levels relative to wild-type littermates at P15 (62.5 mg/dl vs 43.8 mg/dl, respectively) (MGI Ref ID J:7689)
- increased blood uric acid level
- significantly increased blood uric acid levels relative to wild-type littermates at P15 (4.6 mg/dl vs 1.2 mg/dl, respectively) (MGI Ref ID J:7689)
- increased circulating alkaline phosphatase level
- significantly increased circulating alkaline phosphatase levels relative to wild-type littermates at P15 (1020 mU/ml vs 385 mU/ml, respectively) (MGI Ref ID J:7689)
- increased circulating cholesterol level
- significantly increased serum cholesterol levels relative to wild-type littermates at P15 (1.92 ± 0.18 mg/ml vs 1.12 ± 0.04 mg/ml, respectively) (MGI Ref ID J:7689)
- liver/biliary system phenotype
- abnormal liver morphology
- at P15, livers display a lacey appearance and are devoid of fat and glycogen (MGI Ref ID J:7689)
- nervous system phenotype
- abnormal brain vasculature morphology
- at P15, brains display an abundance of capillaries (MGI Ref ID J:7689)
- increased brain weight
- significant increase in brain weight both at P5 and at P15 (MGI Ref ID J:7689)
- cardiovascular system phenotype
- abnormal brain vasculature morphology
- at P15, brains display an abundance of capillaries (MGI Ref ID J:7689)
- hematopoietic system phenotype
- increased thymus weight
- significant increase in thymus weight at P15 but not at P5 (MGI Ref ID J:7689)
- pale spleen
- small spleen
- beginning at ~P5, spleen size is reduced (MGI Ref ID J:7689)
- decreased spleen weight
- significant reduction in spleen weight both at P5 and at P15 (MGI Ref ID J:7689)
anx/anx
involves: DW/J * M. m. domesticus poschiavinus * Swiss
- mortality/aging
- premature death
- mutant mice die in a state of anorexia and emaciation at ~P22 (MGI Ref ID J:13936)
- behavior/neurological phenotype
- abnormal gait
- uncoordinated gait (MGI Ref ID J:13936)
- decreased eating behavior
- hyperactivity (MGI Ref ID J:13936)
- tremors
- head and body tremors (MGI Ref ID J:13936)
- growth/size phenotype
- decreased body weight
- significant reduction in body weight (MGI Ref ID J:13936)
- cachexia
- emaciation by ~P22 (MGI Ref ID J:13936)
- digestive/alimentary phenotype
- abnormal digestive system morphology
- hematopoietic system phenotype
- abnormal spleen morphology
- small spleen
- beginning at ~P5, spleen size is reduced (MGI Ref ID J:13936)
- homeostasis/metabolism phenotype
- decreased body temperature
- hypothermia at ~P22 (MGI Ref ID J:13936)
- liver/biliary system phenotype
- abnormal liver morphology
- at P15, livers are devoid of fat and glycogen (MGI Ref ID J:13936)
- nervous system phenotype
- abnormal brain vasculature morphology
- at P15, brains display an abundance of capillaries, suggesting hyperemia (MGI Ref ID J:13936)
- cardiovascular system phenotype
- abnormal brain vasculature morphology
- at P15, brains display an abundance of capillaries, suggesting hyperemia (MGI Ref ID J:13936)
- immune system phenotype
- abnormal spleen morphology
- small spleen
- beginning at ~P5, spleen size is reduced (MGI Ref ID J:13936)
This mouse can be used to support research in many areas including:anx related
Metabolism Research
Neurobiology Research
Ataxia (Movement) Defects
Behavioral and Learning Defects
Metabolic Defects
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | a | ||
|---|---|---|---|
| Allele Name | nonagouti | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | old mutant of the mouse fancy | ||
| Gene Symbol and Name | a, nonagouti | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | AGSW; AGTI; AGTIL; ASP; As; SHEP9; agouti; agouti signal protein; agouti suppressor; | ||
| Molecular Note | Characterization of this allele shows an insertion of DNA comprised of a 5.5kb virus-like element, VL30, into the first intron of the agouti gene. The VL30 element itself contains an additional 5.5 kb sequence, flanked by 526 bp of direct repeats. The host integration site is the same as for at-2Gso and Aw-38J and includes a duplication of four nucleotides of host DNA and a deletion of 2 bp from the end of each repeat. Northern analysis of mRNA from skin of homozygotes shows a smaller agouti message and levels 8 fold lower than found in wild-type. [MGI Ref ID J:16984] [MGI Ref ID J:24934] | ||
| Allele Symbol | anx | ||
| Allele Name | anorexia | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | (DW/J x (M. m. domesticus poschiavinus x Swiss))F2 | ||
| Gene Symbol and Name | anx, anorexia | ||
| Chromosome | 2 | ||
| General Note | Phenotypic Similarity to Human Syndrome: Anorexia (J:136782) | ||
References
References provided by MGI
Additional References
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Broberger C; Johansen J; Schalling M; Hokfelt T. 1997. Hypothalamic neurohistochemistry of the murine anorexia (anx/anx) mutation: altered processing of neuropeptide Y in the arcuate nucleus. J Comp Neurol 387(1):124-35. [PubMed: 9331176] [MGI Ref ID J:43306]
Jahng JW; Houpt TA; Kim SJ; Joh TH; Son JH. 1998. Neuropeptide Y mRNA and serotonin innervation in the arcuate nucleus of anorexia mutant mice. Brain Res 790(1-2):67-73. [PubMed: 9593828] [MGI Ref ID J:47750]
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Son JH; Baker H; Park DH; Joh TH. 1994. Drastic and selective hyperinnervation of central serotonergic neurons in a lethal neurodevelopmental mouse mutant, Anorexia (anx). Brain Res Mol Brain Res 25(1-2):129-34. [PubMed: 7984037] [MGI Ref ID J:19535]
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Suwa A; Yoshino M; Yamazaki C; Naitou M; Fujikawa R; Matsumoto S; Kurama T; Shimokawa T; Aramori I. 2010. RMI1 deficiency in mice protects from diet and genetic-induced obesity. FEBS J 277(3):677-86. [PubMed: 20050919] [MGI Ref ID J:168271]
Tamate HB; Takeuchi T. 1981. Induction of the shift in melanin synthesis in lethal yellow (A<y>/a) mice in vitro. Dev Genet 2:349-356. [MGI Ref ID J:11956]
Tanaka S; Kuwahara S; Nishijima K; Ohno T; Matsuzawa A. 2006. Genetic association of mutation at agouti locus with adrenal x zone morphology in BALB/c mice. Exp Anim 55(4):343-7. [PubMed: 16880681] [MGI Ref ID J:111619]
Tanaka S; Nishimura M; Matsuzawa A. 1994. Genetic association between agouti locus and adrenal X zone morphology in SM/J mice. Acta Anat (Basel) 149(3):170-3. [PubMed: 7976166] [MGI Ref ID J:19308]
The Mammalian Genetics Unit at Harwell. 2004. Information obtained from the Mammalian Genetics Unit, Medical Research Council (MRC), Harwell, UK Unpublished :. [MGI Ref ID J:90559]
Tsuruta Y; Yoshimatsu H; Hidaka S; Kondou S; Okamoto K; Sakata T. 2002. Hyperleptinemia in A(y)/a mice upregulates arcuate cocaine- and amphetamine-regulated transcript expression. Am J Physiol Endocrinol Metab 282(4):E967-73. [PubMed: 11882520] [MGI Ref ID J:75872]
Vrieling H; Duhl DM; Millar SE; Miller KA; Barsh GS. 1994. Differences in dorsal and ventral pigmentation result from regional expression of the mouse agouti gene. Proc Natl Acad Sci U S A 91(12):5667-71. [PubMed: 8202545] [MGI Ref ID J:18750]
Wolff GL. 1978. Influence of maternal phenotype on metabolic differentiation of agouti locus mutants in the mouse. Genetics 88(3):529-39. [PubMed: 640377] [MGI Ref ID J:5964]
Woychik RP; Generoso WM; Russell LB; Cain KT; Cacheiro NL; Bultman SJ; Selby PB; Dickinson ME; Hogan BL; Rutledge JC. 1990. Molecular and genetic characterization of a radiation-induced structural rearrangement in mouse chromosome 2 causing mutations at the limb deformity and agouti loci. Proc Natl Acad Sci U S A 87(7):2588-92. [PubMed: 2320577] [MGI Ref ID J:10399]
Wu Q; Howell MP; Cowley MA; Palmiter RD. 2008. Starvation after AgRP neuron ablation is independent of melanocortin signaling. Proc Natl Acad Sci U S A 105(7):2687-92. [PubMed: 18272480] [MGI Ref ID J:132184]
Broberger C; Johansen J; Brismar H; Johansson C; Schalling M ; Hokfelt T. 1999. Changes in neuropeptide Y receptors and pro-opiomelanocortin in the anorexia (anx/anx) mouse hypothalamus. J Neurosci 19(16):7130-9. [PubMed: 10436066] [MGI Ref ID J:56665]
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Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, RG10/RG30.
Purchasing information
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $1980.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
Supply Notes
- Cryorecovery of Strains Needing Progeny Testing.
At least two untested males and two untested females (two pairs) will be recovered (eight or more mice is typical). The total number of animals provided, their gender and genotype will vary. Untested animals typically are available to ship between 13 and 16 weeks from the date of your order. If the first recovery attempt is unsuccessful, a second recovery will be done, extending the overall recovery time to approximately 25 weeks.Progeny testing is required to identify the genotype of mice of this strain, as a genotyping assay is not available. This type of testing involves breeding the recovered animals and assessing the phenotype of the offspring in order to identify animals carrying the mutation of interest. We can perform the progeny testing for you as a service or we can ship all recovered animals to you for progeny testing at your facility. If you perform the progeny testing, there is NO guarantee that a carrier will be identified. If we perform progeny testing as a service, additional breeding time will be required. In this case, when a male and female (one pair) are identified that carry the mutation, they and their offspring will be shipped. Delivery time for strains requiring progeny testing often exceeds 25 weeks and may take 12 months or more due to the difficulties in breeding some strains. The progeny testing cost is in addition to the recovery cost and is based on the number of boxes used and the time taken to produce the mice identified as carrying the mutation. Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Please contact Customer Service for more information on the cost of progeny testing for a strain: Tel: 1-800-422-6423 (from U.S.A., Canada and Puerto Rico only) or 1-207-288-5845 (from any location). The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.
Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
| Pricing for International shipping destinations |
|
|
Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $2574.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
Supply Notes
- Cryorecovery of Strains Needing Progeny Testing.
At least two untested males and two untested females (two pairs) will be recovered (eight or more mice is typical). The total number of animals provided, their gender and genotype will vary. Untested animals typically are available to ship between 13 and 16 weeks from the date of your order. If the first recovery attempt is unsuccessful, a second recovery will be done, extending the overall recovery time to approximately 25 weeks.Progeny testing is required to identify the genotype of mice of this strain, as a genotyping assay is not available. This type of testing involves breeding the recovered animals and assessing the phenotype of the offspring in order to identify animals carrying the mutation of interest. We can perform the progeny testing for you as a service or we can ship all recovered animals to you for progeny testing at your facility. If you perform the progeny testing, there is NO guarantee that a carrier will be identified. If we perform progeny testing as a service, additional breeding time will be required. In this case, when a male and female (one pair) are identified that carry the mutation, they and their offspring will be shipped. Delivery time for strains requiring progeny testing often exceeds 25 weeks and may take 12 months or more due to the difficulties in breeding some strains. The progeny testing cost is in addition to the recovery cost and is based on the number of boxes used and the time taken to produce the mice identified as carrying the mutation. Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Please contact Customer Service for more information on the cost of progeny testing for a strain: Tel: 1-800-422-6423 (from U.S.A., Canada and Puerto Rico only) or 1-207-288-5845 (from any location). The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.
Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
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Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
General Supply Notes
- This strain is included in the Mouse Mutant Resource collection.
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| Untyped from the colony | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
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Terms of Use
Terms of Use
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Contact information
General inquiriesContracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.