JAX Mice Database - 000627 C3H/HeJ-Kit<W-x>/J

Strain Name:	C3H/HeJ-Kit^W-x/J
Stock Number:	000627
Availability:	Repository-Cryopreserved

Description
Phenotype
Genes & alleles
Genotyping
Health & husbandry
References
Purchasing information
Terms of Use

Description

Strain Information

Type Coisogenic; Mutant Strain; Spontaneous Mutation;
Additional information on Genetically Engineered Mutant Mice.

Species laboratory mouse

Control Information

	Control
	Wild-type from the colony

Considerations for Choosing Controls

Related Strains

Strains carrying Kit^W-x allele

000965 CBACa.C3-Kit^W-x/J

View Strains carrying Kit^W-x (1 strain)

Strains carrying other alleles of Kit

000599 B6 x B6CBCa A^w-J/A-T(5;13)264Ca Kit^W-v/J

006564 B6(C)-Kit^W-41J Gusb^mps/BrkJ

000495 B6.C-H38^c/By-Kit^W-56J/J

000560 B6.C-H7^b/By Kit^W-50J/J

000122 B6.C3-Kit^W-44J/J

000991 B6.C58-Kit^W-57J/J

002283 B6.Cg-Kit^W-19H/EiJ

000133 B6.Cg-Kit^W-24J/J

000139 B6.Cg-Kit^W-25J/J

005051 B6.Cg-Kit^W-sh/HNihrJaeBsmJ

000164 B6.Cg-Kit^W/J

000194 B6.Cg-Lx Kit^W-v/J

000171 B6.D2-Kit^W-45J/J

001563 B6.D2-Kit^W-73J/J

001177 B6.LP-Kit^W-49J/J

000350 B6By.Cg-Kit^W-v Mitf^Mi-wh T/J

000847 C3Sn.B6-Kit^W-39J/J

000166 C57BL/6J-Kit^W-17J/J

000167 C57BL/6J-Kit^W-18J/J

000169 C57BL/6J-Kit^W-20J/J

000117 C57BL/6J-Kit^W-34J/J

000128 C57BL/6J-Kit^W-35J/J

000134 C57BL/6J-Kit^W-37J/J

000062 C57BL/6J-Kit^W-39J/J

000121 C57BL/6J-Kit^W-40J/J

000119 C57BL/6J-Kit^W-41J/J

000127 C57BL/6J-Kit^W-42J/J

000129 C57BL/6J-Kit^W-43J/J

000990 C57BL/6J-Kit^W-55J/J

001179 C57BL/6J-Kit^W-62J/J

000049 C57BL/6J-Kit^W-v/J

000092 FL/1Re-Kit^W/J

000993 NZB/BlNJ-Kit^W-59J/J

000692 WB/ReJ Kit^W/J

100410 WBB6F1/J-Kit^W/Kit^W-v/J

View Strains carrying other alleles of Kit (35 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms
assigned by genotype

Kit^W-x/Kit⁺
involves: C3H/HeJ
pigmentation phenotype

abnormal coat color (MGI Ref ID J:3398)

authors state that this mouse in indistinguishable from Kit^W mice

skin/coat/nails phenotype

abnormal coat color (MGI Ref ID J:3398)

authors state that this mouse in indistinguishable from Kit^W mice

Kit^W-x/Kit^W-x
involves: C3H/HeJ
pigmentation phenotype

abnormal coat color (MGI Ref ID J:3398)

authors state that this mouse in indistinguishable from Kit^W mice

skin/coat/nails phenotype

abnormal coat color (MGI Ref ID J:3398)

authors state that this mouse in indistinguishable from Kit^W mice

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:
Kit^W-x related

Cancer Research
Growth Factors/Receptors/Cytokines
Increased Tumor Incidence (Gonadal Tumors: ovarian)
Oncogenes

Dermatology Research
Color and White Spotting Defects

Developmental Biology Research
Neural Crest Defects

Endocrine Deficiency Research
Bone/Bone Marrow Defects
Gonad Defects
Skin Defects

Immunology and Inflammation Research
Immunodeficiency (Mast Cell Deficiency)

Mouse/Human Gene Homologs
piebaldism

Neurobiology Research
Receptor Defects
Vestibular and Hearing Defects

Reproductive Biology Research
Developmental Defects Affecting Gonads (germ cell deficient)
Fertility Defects
Gonadal Tumors (ovarian)

Research Tools
Immunology and Inflammation Research (Mast Cell Deficiency)

Sensorineural Research
Vestibular and Hearing Defects

Genes & Alleles

Gene & Allele Information

Allele Symbol		Kit^W-x
Allele Name		dominant spotting x
Allele Type		Spontaneous
Strain of Origin		C3H/HeJ
Gene Symbol and Name		Kit, kit oncogene
Chromosome		5
Gene Common Name(s)		Bs; C-Kit; CD117; Dominant white spotting; Fdc; Gsfsco1; Gsfsco5; Gsfsow3; PBT; SCFR; SCO1; SCO5; SOW3; Ssm; Steel Factor Receptor; Tr-kit; W; belly-spot; dominant spotting; gsf spotted coat 1; gsf spotted coat 5; phenotype like Sl or W 3; spotted sterile male;
Molecular Note		This allele involves a rearrangement in the Kit gene (J:9374). [MGI Ref ID J:9374]

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Optimizing PCR Protocols

References

Additional References

Arguello F; Furlanetto RW; Baggs RB; Graves BT; Harwell SE; Cohen HJ; Frantz CN. 1992. Incidence and distribution of experimental metastases in mutant mice with defective organ microenvironments (genotypes Sl/Sld and W/Wv). Cancer Res 52(8):2304-9. [PubMed: 1559233] [MGI Ref ID J:468]

Kitamura Y; Kasugai T; Ebi Y; Nomura S. 1991. Fibroblast-dependent differentiation/proliferation of mast cells. Skin Pharmacol 4 Suppl 1:2-7. [PubMed: 1764248] [MGI Ref ID J:619]

Murphy ED. 1972. Hyperplastic and early neoplastic changes in the ovaries of mice after genic deletion of germ cells. J Natl Cancer Inst 48(5):1283-95. [PubMed: 4337905] [MGI Ref ID J:5274]

Nocka K; Tan JC; Chiu E; Chu TY; Ray P; Traktman P; Besmer P. 1990. Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W. EMBO J 9(6):1805-13. [PubMed: 1693331] [MGI Ref ID J:10528]
Kit^W-x related

Beamer WG; Tennent BJ. 1986. Gonadotropin uptake in genetic and irradiation models of ovarian tumorigenesis. Biol Reprod 34(4):761-70. [PubMed: 3085740] [MGI Ref ID J:48594]

Cable J; Huszar D; Jaenisch R; Steel KP. 1994. Effects of mutations at the W locus (c-kit) on inner ear pigmentation and function in the mouse. Pigment Cell Res 7(1):17-32. [PubMed: 7521050] [MGI Ref ID J:21178]

Geissler EN; Ryan MA; Housman DE. 1988. The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene. Cell 55(1):185-92. [PubMed: 2458842] [MGI Ref ID J:9374]

Murphy ED; Beamer WG. 1973. Plasma gonadotropin levels during early stages of ovarian tumorigenesis in mice of the W x -W v genotype. Cancer Res 33(4):721-3. [PubMed: 4696472] [MGI Ref ID J:48589]

Russell ES; Lawson F; Schabtach G. 1957. Evidence for a new allele at the W-locus of the mouse J Hered 48:119-23. [MGI Ref ID J:3398]

Tennent BJ; Beamer WG. 1986. Ovarian tumors not induced by irradiation and gonadotropins in hypogonadal (hpg) mice. Biol Reprod 34(4):751-60. [PubMed: 3708055] [MGI Ref ID J:48591]

Health & husbandry

Health & Colony Maintenance Information

Currently there no information available for this strain. This may be due to the supply level of this strain.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations

Weeks of Age Price* Gender

Cryorecovery Fee $1900.00

*Price(s) in US dollars ($)

Weeks of Age	Price*	Gender
Cryorecovery Fee	$1900.00

Additional Supply Details

Pricing for International shipping destinations

Weeks of Age Price* Gender

Cryorecovery Fee $2470.00

*Price(s) in US dollars ($)

Weeks of Age	Price*	Gender
Cryorecovery Fee	$2470.00

Additional Supply Details

Supply Details

Standard Supply	Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes	Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. *Cryorecovery to establish a Dedicated Supply for greater quantities of mice.* One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX^® Services, Tel: 1-800-422-6423 or 1-207-288-5845. Genomic DNA is available for this strain from the Mouse DNA Resource.

Standard Supply

Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.

Supply Notes

Cryorecovery - Standard.
The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.
Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX^® Services, Tel: 1-800-422-6423 or 1-207-288-5845.
Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

	Control
	Wild-type from the colony

Considerations for Choosing Controls
USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
International - Control Pricing Information for Genetically Engineered Mutant Strains.

General Terms and Conditions

See Terms of Use

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

Ordering and Purchasing Information

Purchasing Information
JAX^® Mice Orders
Surgical Services

Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form

Terms of Use

General Terms and Conditions

Contact information

General inquiries

Contracts Administration

phone:	207-288-6470
fax:	207-288-6655

JAX^® Mice & Services Conditions of Use

“Each recipient institution, including its employees and other researchers under its control (RECIPIENT), of mice or services using mice from The Jackson Laboratory (TJL) agrees that such mice, descendants of those mice derived by inbreeding or crossbreeding, including unmodified derivatives of those mice or their descendants (“MICE”) shall not be: (i) used for any purpose other than the internal research of the RECIPIENT, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services with respect to MICE. Acceptance of MICE from TJL shall be deemed agreement by RECIPIENT to these conditions, and departure from these conditions requires The Jackson Laboratory’s prior written authorization.”

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. THE LABORATORY EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of MICE, products or services, The Jackson Laboratory will, at its option, provide credit or replacement for the MICE or product received or the services provided.

No Liability

In no event shall The Jackson Laboratory, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, products or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of The Jackson Laboratory, its agents or employees. In purchasing or receiving MICE, products or services from The Jackson Laboratory, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges The Jackson Laboratory from all such causes of action or damages, and further agrees to defend and indemnify The Jackson Laboratory from any costs or damages arising out of any third party claims.

MICE and biological materials are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to The Jackson Laboratory’s MICE, products and services. In addition, special terms and conditions of sale of certain MICE, products and services may be set forth separately in The Jackson Laboratory web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, products and services by The Jackson Laboratory, and by its licensees and distributors.

Acceptance of delivery of MICE, products or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on The Jackson Laboratory, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, products services by The Jackson Laboratory.

000599	B6 x B6CBCa A^w-J/A-T(5;13)264Ca Kit^W-v/J
006564	B6(C)-Kit^W-41J Gusb^mps/BrkJ
000495	B6.C-H38^c/By-Kit^W-56J/J
000560	B6.C-H7^b/By Kit^W-50J/J
000122	B6.C3-Kit^W-44J/J
000991	B6.C58-Kit^W-57J/J
002283	B6.Cg-Kit^W-19H/EiJ
000133	B6.Cg-Kit^W-24J/J
000139	B6.Cg-Kit^W-25J/J
005051	B6.Cg-Kit^W-sh/HNihrJaeBsmJ
000164	B6.Cg-Kit^W/J
000194	B6.Cg-Lx Kit^W-v/J
000171	B6.D2-Kit^W-45J/J
001563	B6.D2-Kit^W-73J/J
001177	B6.LP-Kit^W-49J/J
000350	B6By.Cg-Kit^W-v Mitf^Mi-wh T/J
000847	C3Sn.B6-Kit^W-39J/J
000166	C57BL/6J-Kit^W-17J/J
000167	C57BL/6J-Kit^W-18J/J
000169	C57BL/6J-Kit^W-20J/J
000117	C57BL/6J-Kit^W-34J/J
000128	C57BL/6J-Kit^W-35J/J
000134	C57BL/6J-Kit^W-37J/J
000062	C57BL/6J-Kit^W-39J/J
000121	C57BL/6J-Kit^W-40J/J
000119	C57BL/6J-Kit^W-41J/J
000127	C57BL/6J-Kit^W-42J/J
000129	C57BL/6J-Kit^W-43J/J
000990	C57BL/6J-Kit^W-55J/J
001179	C57BL/6J-Kit^W-62J/J
000049	C57BL/6J-Kit^W-v/J
000092	FL/1Re-Kit^W/J
000993	NZB/BlNJ-Kit^W-59J/J
000692	WB/ReJ Kit^W/J
100410	WBB6F1/J-Kit^W/Kit^W-v/J

Strain Name:

C3H/HeJ-KitW-x/J

Stock Number:

000627

Availability:

Repository-Cryopreserved

Strain Information

Control Information

Related Strains

Phenotype Information

KitW-x/Kit+

KitW-x/KitW-x

Gene & Allele Information

Genotyping Information

Helpful Links

References

Additional References

Health & Colony Maintenance Information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Additional Supply Details

Additional Supply Details

Supply Details

Control Information

General Terms and Conditions

See Terms of Use

The Jackson Laboratory's Genotype Promise

Terms of Use

Contact information

Contracts Administration

JAX® Mice & Services Conditions of Use

No Warranty

No Liability

C3H/HeJ-Kit^W-x/J

Kit^W-x/Kit⁺

Kit^W-x/Kit^W-x

JAX^® Mice & Services Conditions of Use