Strain Name: |
C57BL/6J-Lystbg-J/J |
|---|---|
Stock Number: |
000629 |
Availability: | Level 4 |
General Terms and Conditions |
| Genes & Alleles | Lyst; Lystbg-J; |
Product Information
Strain Details
Type JAX® GEMM® Strain - Coisogenic Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Mutant Strain Type JAX® GEMM® Strain - Spontaneous Mutation Mating System Homozygote x Homozygote (Female x Male) Species laboratory mouse Generation N11F6 (03-JAN-08) Appearance
dark gray, affected
Related Genotype: a/a Lystbg-J/Lystbg-J
black, unaffected
Related Genotype: a/a Lystbg-J/+Strain Description
Mice homozygous for the beige-J spontaneous mutation (Lystbg-J) are identical to the original beige mutation (Lystbg). The phenotype closely resembles Chediak-Higashi disease in man and similar conditions in mink and cattle. Abnormal giant lysosomal granules occur in all tissues with granule-containing cells, including granulocytes, lymphocytes, cells of the liver, kidney, central nervous system, pancreas, and thyroid, and the ducts of most glands; in type II pneumocytes; in mast cells; and in retinal pigment epithelium. Granulocytes from beige homozygous mutant mice mice show defective chemotaxis and reduced bactericidal activity. Beige mice are more susceptible than controls to pneumonitis and to various viral, bacterial, and parasitic infections. Natural killer (NK) cells from beige mice exhibit decreased endogenous cytotoxic activity. Beige mice also have a defective cytotoxic T-cell and cytotoxic antibody response to allogeneic tumor cells. Syngeneic tumor cells grow better in beige mice than in littermate controls, an effect thought to be due to the deficiency of NK cells. Beige mice have platelet storage pool deficiency, leading to a prolonged bleeding time. The immunodeficiency of beige mutant mice has been used, especially in combination with the scid mutation (Prkdcscid), in tissue graft and disease studies.
Mammalian Phenotype Terms assigned by genotype |
Gene & Allele Details
| Allele Symbol | Lystbg-J | ||
|---|---|---|---|
| Allele Name | beige Jackson | ||
| Common Name(s) | bgj; | ||
| Strain of Origin | C57BL/6J | ||
| Gene Symbol and Name | Lyst, lysosomal trafficking regulator | ||
| Chromosome | 13 | ||
| Gene Common Name(s) | Beige; CHS; CHS1; D13Sfk13; DNA segment, Chr 13, Stephen F. Kingsmore 13; beige; bg; | ||
| General Note | This remutation occurred spontaneously in the C57BL/6J strain at The Jackson Laboratory (J:5311). It has essentially identical effects to the original Lystbg mutation, and has been used extensively in defining locus effects. | ||
| Molecular Note | This allele is defined by a noncomplementation test with Lystbg. Although mice homozygous for this allele show a decrease in Lyst mRNA in the liver compared to normal, the molecular basis for this allele is not yet known. [MGI Ref ID J:7539] | ||
Control Information
| Allele | Control | |
|---|---|---|
| Lystbg-J | 000664 C57BL/6J | |
| Considerations for Choosing Controls | ||
Colony Maintenance
| Diet Information | LabDiet® 5K52/5K67 |
|---|
Related Strains
Strains carrying Lystbg-J allele
000604 B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J View Strains carrying Lystbg-J (1 strain)
000204 B6.Cg-Lystbg/J 000604 B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J 000509 C3H/HeJ-Lystbg-2J/J 000494 J.Cg-Oca2+ Tyr+ Lystbg/J 000269 SB/LeJ
Additional Web Information
Genetic Quality Control Annual Report
JAX® NOTES, Spring 1991; 445. Why C57BL/6J-bgJ (beige) Mice are not Beige.
JAX® NOTES, Spring 2003; 489. Role of NK and NKT Cells in Immunity and Disease.
JAX® NOTES, Winter 1992; 448. The Beige (BgJ) Mutation.
Animal Health Reports
Room Number AX30
Research Applications
This mouse can be used to support research in many areas including:Lystbg-J related
Cardiovascular Research
Atherosclerosis
Dermatology Research
Color and White Spotting Defects
Hematological Research
Immunological Defects
Platelet Defects (platelet storage pool deficiency)
Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunodeficiency (NK Cell and Cd8 T Cell defects)
Immunodeficiency Associated with Other Defects
Intracellular Signaling Molecules
Internal/Organ Research
Kidney Defects (lysosomal enzyme abnormalities)
Metabolism Research
Mouse/Human Gene Homologs
Chediak-Higashi syndrome
Research Tools
Immunology and Inflammation Research (NK Cell Deficiency)
References
Selected Reference(s)
Additional ReferencesGallin JI; Bujak JS; Patten E; Wolff SM. 1974. Granulocyte function in the Chediak-Higashi syndrome of mice. Blood 43(2):201-6. [PubMed: 4589319] [MGI Ref ID J:5405]
Perou CM; Moore KJ; Nagle DL; Misumi DJ; Woolf EA; McGrail SH; Holmgren L; Brody TH; Dussault BJ Jr; Monroe CA; Duyk GM; Pryor RJ; Li L; Justice MJ; Kaplan J. 1996. Identification of the murine beige gene by YAC complementation and positional cloning. Nat Genet 13(3):303-8. [PubMed: 8673129] [MGI Ref ID J:33734]
Roder JC. 1979. The beige mutation in the mouse. I. A stem cell predetermined impairment in natural killer cell function. J Immunol 123(5):2168-73. [PubMed: 489978] [MGI Ref ID J:6213]
Price and Supply Information
| Strain Name: | C57BL/6J-Lystbg-J/J |
| Stock Number: | 000629 |
Price Details
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Supply Details
| Standard Supply | Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months. |
|---|---|
| Supply Notes |
Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available. Strains that must be genotyped are not available until five to seven weeks of age. Genomic DNA is available for this strain from the Mouse DNA Resource. |
| Licensing | See General Terms and Conditions below |
| Control Information | View Control Information in Strain Details. |
General Terms and Conditions
View JAX® Mice & Services Conditions of Use.
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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