Strain Name:

C57BL/6J-Lystbg-J/J

Stock Number:

000629

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Availability:

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The beige-J spontaneous mutation Lystbg-J) is a remutation to (Lystbg, and homozygous Lystbg-J mice have an essentially identical phenotype to the original mutants. Homozygotes are immunodeficient, exhibiting decreased endogenous cytotoxic activity as well as having defective cytotoxic T-cell and cytotoxic antibody responses to allogeneic tumor cells. The phenotype closely resembles Chediak-Higashi disease in man.

Description

Strain Information

Type Coisogenic; Mutant Strain; Spontaneous Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Mating SystemHomozygote x Homozygote         (Female x Male)   26-DEC-07
Breeding Considerations This strain is a good breeder.
Specieslaboratory mouse
GenerationN11F9+F12 (24-JAN-14)
Generation Definitions
 
Donating Investigator The Jackson Laboratory,  

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Appearance
dark gray, affected
Related Genotype: a/a Lystbg-J/Lystbg-J

black, unaffected
Related Genotype: a/a Lystbg-J/+

Description
Mice homozygous for the beige-J spontaneous mutation (Lystbg-J) are identical to the original beige mutation (Lystbg). The phenotype closely resembles Chediak-Higashi disease in man and similar conditions in mink and cattle. Abnormal giant lysosomal granules occur in all tissues with granule-containing cells, including granulocytes, lymphocytes, cells of the liver, kidney, central nervous system, pancreas, and thyroid, and the ducts of most glands; in type II pneumocytes; in mast cells; and in retinal pigment epithelium. Granulocytes from beige homozygous mutant mice show defective chemotaxis and reduced bactericidal activity. Beige mice are more susceptible than controls to pneumonitis and to various viral, bacterial, and parasitic infections. Natural killer (NK) cells from beige mice exhibit decreased endogenous cytotoxic activity. Beige mice also have a defective cytotoxic T-cell and cytotoxic antibody response to allogeneic tumor cells. Syngeneic tumor cells grow better in beige mice than in littermate controls, an effect thought to be due to the deficiency of NK cells. Beige mice have platelet storage pool deficiency, leading to a prolonged bleeding time. The immunodeficiency of beige mutant mice has been used, especially in combination with the scid mutation (Prkdcscid), in tissue graft and disease studies.

Development
The bg-J mutation arose spontaneously in the C57BL/6J colony at The Jackson Laboratory in 1960. The allele is defined by a non-complementation test with bg.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Lystbg-J allele
000604   B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J
View Strains carrying   Lystbg-J     (1 strain)

Strains carrying other alleles of Lyst
000204   B6.C3Rl-Lystbg/J
000604   B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J
000509   C3.Cg-Lystbg-2J/J
000494   J.Cg-Oca2+ Tyr+ Lystbg/J
000269   SB/LeJ
010968   SB;C3Sn-Lrp4mdig-2J/GrsrJ
View Strains carrying other alleles of Lyst     (6 strains)

Additional Web Information

JAX® NOTES, Spring 1991; 445. Why C57BL/6J-bgJ (beige) Mice are not Beige.
JAX® NOTES, Spring 2003; 489. Role of NK and NKT Cells in Immunity and Disease.
JAX® NOTES, Winter 1992; 448. The Beige (BgJ) Mutation.

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Model with phenotypic similarity to human disease where etiologies are distinct. Human genes are associated with this disease. Orthologs of these genes do not appear in the mouse genotype(s).
Exfoliation Syndrome; XFS
Models with phenotypic similarity to human diseases where etiology is unknown or involving genes where ortholog is unknown.
Storage Pool Platelet Disease
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Chediak-Higashi Syndrome; CHS   (LYST)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Lystbg-J/Lystbg-J

        C57BL/6J-Lystbg-J/J
  • immune system phenotype
  • abnormal granulocyte morphology
    • granulocytes are characterized by giant lysosomal sudanophilic granules   (MGI Ref ID J:34814)
    • abnormal neutrophil morphology
      • neutrophil lysosomal extracts have decreased elastase activity   (MGI Ref ID J:34814)
  • decreased macrophage cell number
    • F4/80+ splenic macrophages are decreased in comparison to control (3.8% vs. 8.8%)   (MGI Ref ID J:34814)
  • impaired natural killer cell mediated cytotoxicity
    • NK cell activity is decreased in comparison to B6 control   (MGI Ref ID J:34814)
  • hematopoietic system phenotype
  • abnormal granulocyte morphology
    • granulocytes are characterized by giant lysosomal sudanophilic granules   (MGI Ref ID J:34814)
    • abnormal neutrophil morphology
      • neutrophil lysosomal extracts have decreased elastase activity   (MGI Ref ID J:34814)
  • decreased macrophage cell number
    • F4/80+ splenic macrophages are decreased in comparison to control (3.8% vs. 8.8%)   (MGI Ref ID J:34814)
  • decreased platelet ADP level
    • platelet ADP levels are much lower than in C57BL/6J controls   (MGI Ref ID J:7327)
  • decreased platelet ATP level
    • platelet ATP levels are much lower than in C57BL/6J controls   (MGI Ref ID J:7327)
  • decreased platelet serotonin level
    • less than 1% of normal platelet serotonin levels   (MGI Ref ID J:7327)
  • impaired natural killer cell mediated cytotoxicity
    • NK cell activity is decreased in comparison to B6 control   (MGI Ref ID J:34814)
  • homeostasis/metabolism phenotype
  • decreased platelet serotonin level
    • less than 1% of normal platelet serotonin levels   (MGI Ref ID J:7327)
  • increased bleeding time
    • bleed time averaging over 11 minutes after tail nick is much greater than the 3.8 minutes for C57BL/6J controls   (MGI Ref ID J:7327)
  • cellular phenotype
  • decreased lysosomal enzyme secretion
    • thrombin stimulation of platelets results in approximately half normal levels of secretion of beta-glucuronidase and beta-galactosidase   (MGI Ref ID J:7327)
  • vision/eye phenotype
  • *normal* vision/eye phenotype
    • do not develop glaucoma   (MGI Ref ID J:173521)
    • no optic nerve damage   (MGI Ref ID J:173521)
    • abnormal anterior uvea morphology   (MGI Ref ID J:173521)
      • abnormal iridocorneal angle
        • accumulation of pigment and debris   (MGI Ref ID J:173521)
      • abnormal iris morphology   (MGI Ref ID J:173521)
        • abnormal iris pigment epithelium
          • enlarged melanosomes present   (MGI Ref ID J:173521)
        • abnormal iris pigmentation
          • iris pigment is very dark and dispersed   (MGI Ref ID J:141035)
          • dark gray   (MGI Ref ID J:173521)
          • pronounced pigment dispersion by 3 months   (MGI Ref ID J:173521)
          • sawtooth-like morphology of iris pigment   (MGI Ref ID J:173521)
        • abnormal iris stroma morphology
          • dysmorphic iris stroma   (MGI Ref ID J:173521)
          • anterior iris stroma thinned   (MGI Ref ID J:173521)
          • concentric periodic iris transillumination   (MGI Ref ID J:173521)
    • abnormal eye anterior chamber morphology
      • accumulation of exfoliated materials throughout the anterior chamber   (MGI Ref ID J:173521)
      • pigment engulfed macrophage and enlarged melanosomes   (MGI Ref ID J:173521)
  • behavior/neurological phenotype
  • abnormal gait
    • an impaired gait is obvious by 17 months of age   (MGI Ref ID J:15166)
  • abnormal vestibuloocular reflex
    • mice exhibit an inverted optokinetic nystagmus in response to stimulation of only the temporal retina   (MGI Ref ID J:29747)
    • mice exhibit eye movements with a vertical component in response to horizontally moving, full-field stimuli   (MGI Ref ID J:29747)
  • impaired balance
    • obvious by 17 months of age   (MGI Ref ID J:15166)
  • impaired swimming
    • mice lose the ability to swim by 17 months of age   (MGI Ref ID J:15166)
  • paraparesis
    • motor weakness is noticeable in the hind legs by 17 months of age   (MGI Ref ID J:15166)
  • tremors
    • fine sustained tremors are observed by 17 months of age   (MGI Ref ID J:15166)
  • nervous system phenotype
  • decreased Purkinje cell number
    • there is a complete or nearly complete loss of cells in mice showing neurological symptoms by 17 months of age   (MGI Ref ID J:15166)
    • mice in the second year of life and without abnormal neurological behavior have a significant reduction of cells   (MGI Ref ID J:15166)
  • hearing/vestibular/ear phenotype
  • abnormal vestibuloocular reflex
    • mice exhibit an inverted optokinetic nystagmus in response to stimulation of only the temporal retina   (MGI Ref ID J:29747)
    • mice exhibit eye movements with a vertical component in response to horizontally moving, full-field stimuli   (MGI Ref ID J:29747)
  • pigmentation phenotype
  • abnormal iris pigment epithelium
    • enlarged melanosomes present   (MGI Ref ID J:173521)
  • abnormal iris pigmentation
    • iris pigment is very dark and dispersed   (MGI Ref ID J:141035)
    • dark gray   (MGI Ref ID J:173521)
    • pronounced pigment dispersion by 3 months   (MGI Ref ID J:173521)
    • sawtooth-like morphology of iris pigment   (MGI Ref ID J:173521)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Lystbg-J related

Cardiovascular Research
Atherosclerosis

Dermatology Research
Color and White Spotting Defects

Hematological Research
Immunological Defects
Platelet Defects
      platelet storage pool deficiency

Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunodeficiency
      NK Cell and Cd8 T Cell defects
Immunodeficiency Associated with Other Defects
Intracellular Signaling Molecules

Internal/Organ Research
Kidney Defects
      lysosomal enzyme abnormalities

Metabolism Research

Research Tools
Immunology, Inflammation and Autoimmunity Research
      NK Cell Deficiency

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Lystbg-J
Allele Name beige Jackson
Allele Type Spontaneous
Common Name(s) bgj;
Mutation Made By The Jackson Laboratory,  
Strain of OriginC57BL/6J
Gene Symbol and Name Lyst, lysosomal trafficking regulator
Chromosome 13
Gene Common Name(s) Beige; CHS; CHS1; D13Sfk13; DNA segment, Chr 13, Stephen F. Kingsmore 13; beige; bg;
General Note This remutation occurred spontaneously in the C57BL/6J strain at The Jackson Laboratory (J:5311). It has essentially identical effects to the original Lystbg mutation, and has been used extensively in defining locus effects.
Molecular Note This allele is defined by a noncomplementation test with Lystbg. This mutation is the result of a 3 bp deletion in exon 54 causing an isoleucine deletion at codon 3741 near the carboxy terminus of the protein. This deletion affects the WD40 domain. [MGI Ref ID J:173521] [MGI Ref ID J:7539]

Genotyping

Genotyping Information

Genotyping Protocols

Lystbg-J pyro sequencing, Pyrosequencing

We maintain our C57BL/6J-Lystbg-J/J by intercrossing homozygotes, which obviates the need for genotyping. Homozygotes can be identified readily by their dark gray coat color.

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Gallin JI; Bujak JS; Patten E; Wolff SM. 1974. Granulocyte function in the Chediak-Higashi syndrome of mice. Blood 43(2):201-6. [PubMed: 4589319]  [MGI Ref ID J:5405]

Perou CM; Moore KJ; Nagle DL; Misumi DJ; Woolf EA; McGrail SH; Holmgren L; Brody TH; Dussault BJ Jr; Monroe CA; Duyk GM; Pryor RJ; Li L; Justice MJ; Kaplan J. 1996. Identification of the murine beige gene by YAC complementation and positional cloning. Nat Genet 13(3):303-8. [PubMed: 8673129]  [MGI Ref ID J:33734]

Roder JC. 1979. The beige mutation in the mouse. I. A stem cell predetermined impairment in natural killer cell function. J Immunol 123(5):2168-73. [PubMed: 489978]  [MGI Ref ID J:6213]

Additional References

Chiang EY; Stroynowski I. 2004. A nonclassical MHC class I molecule restricts CTL-mediated rejection of a syngeneic melanoma tumor. J Immunol 173(7):4394-401. [PubMed: 15383569]  [MGI Ref ID J:93729]

Glass WG; Subbarao K; Murphy B; Murphy PM. 2004. Mechanisms of host defense following severe acute respiratory syndrome-coronavirus (SARS-CoV) pulmonary infection of mice. J Immunol 173(6):4030-9. [PubMed: 15356152]  [MGI Ref ID J:92752]

Schiller NK; Black AS; Bradshaw GP; Bonnet DJ; Curtiss LK. 2004. Participation of macrophages in atherosclerotic lesion morphology in LDLr-/- mice. J Lipid Res 45(8):1398-409. [PubMed: 15175354]  [MGI Ref ID J:91367]

Wu HS; Kolonoski P; Chang YY; Bermudez LE. 2000. Invasion of the brain and chronic central nervous system infection after systemic Mycobacterium avium complex infection in mice. Infect Immun 68(5):2979-84. [PubMed: 10768998]  [MGI Ref ID J:61694]

Lystbg-J related

Anderson MG; Hawes NL; Trantow CM; Chang B; John SW. 2008. Iris phenotypes and pigment dispersion caused by genes influencing pigmentation. Pigment Cell Melanoma Res 21(5):565-78. [PubMed: 18715234]  [MGI Ref ID J:141035]

Barbosa MD; Nguyen QA; Tchernev VT; Ashley JA; Detter JC; Blaydes SM; Brandt SJ; Chotai D; Hodgman C; Solari RC; Lovett M; Kingsmore SF. 1996. Identification of the homologous beige and Chediak-Higashi syndrome genes. Nature 382(6588):262-5. [PubMed: 8717042]  [MGI Ref ID J:34205]

Bumgardner GL; Gao D; Li J; Baskin JH; Heininger M; Orosz CG. 2000. Rejection responses to allogeneic hepatocytes by reconstituted SCID mice, CD4, KO, and CD8 KO mice. Transplantation 70(12):1771-80. [PubMed: 11152110]  [MGI Ref ID J:66571]

Bussiere JL; Adler MW; Rogers TJ; Eisenstein TK. 1993. Effects of in vivo morphine treatment on antibody responses in C57BL/6 bgJ/bgJ (beige) mice. Life Sci 52(4):PL43-8. [PubMed: 8421432]  [MGI Ref ID J:4023]

Carlson GA; Marshall ST; Truesdale AT. 1984. Adaptive immune defects and delayed rejection of allogeneic tumor cells in beige mice. Cell Immunol 87(2):348-56. [PubMed: 6467382]  [MGI Ref ID J:7539]

Chatterjee P; Tiwari RK; Rath S; Bal V; George A. 2012. Modulation of antigen presentation and B cell receptor signaling in B cells of beige mice. J Immunol 188(6):2695-702. [PubMed: 22327079]  [MGI Ref ID J:181844]

Chiang EY; Stroynowski I. 2004. A nonclassical MHC class I molecule restricts CTL-mediated rejection of a syngeneic melanoma tumor. J Immunol 173(7):4394-401. [PubMed: 15383569]  [MGI Ref ID J:93729]

Christianson SW; Greiner DL; Schweitzer IB; Gott B; Beamer GL; Schweitzer PA; Hesselton RM; Shultz LD. 1996. Role of natural killer cells on engraftment of human lymphoid cells and on metastasis of human T-lymphoblastoid leukemia cells in C57BL/6J-scid mice and in C57BL/6J-scid bg mice. Cell Immunol 171(2):186-99. [PubMed: 8806787]  [MGI Ref ID J:34814]

Davis SG; Lyerla TA. 1997. The effect of lysosomotropic amines on beige mouse cells. Exp Cell Res 237(1):242-5. [PubMed: 9417888]  [MGI Ref ID J:44747]

Dove WF; Clipson L; Gould KA; Luongo C; Marshall DJ; Moser AR; Newton MA; Jacoby RF. 1997. Intestinal neoplasia in the ApcMin mouse: independence from the microbial and natural killer (beige locus) status. Cancer Res 57(5):812-4. [PubMed: 9041176]  [MGI Ref ID J:38777]

Gardi C; Cavarra E; Calzoni P; Marcolongo P; de Santi M; Martorana PA; Lungarella G. 1994. Neutrophil lysosomal dysfunctions in mutant C57 Bl/6J mice: interstrain variations in content of lysosomal elastase, cathepsin G and their inhibitors. Biochem J 299(Pt 1):237-45. [PubMed: 8166647]  [MGI Ref ID J:17583]

Glass WG; Subbarao K; Murphy B; Murphy PM. 2004. Mechanisms of host defense following severe acute respiratory syndrome-coronavirus (SARS-CoV) pulmonary infection of mice. J Immunol 173(6):4030-9. [PubMed: 15356152]  [MGI Ref ID J:92752]

Gross SK; Lyerla TA; Williams MA; McCluer RH. 1992. The accumulation and metabolism of glycosphingolipids in primary kidney cell cultures from beige mice. Mol Cell Biochem 118(1):61-6. [PubMed: 1488056]  [MGI Ref ID J:21419]

Kveiborg M; Chiusaroli R; Sims NA; Wu M; Sabatakos G; Horne WC; Baron R. 2002. The increased bone mass in deltaFosB transgenic mice is independent of circulating leptin levels. Endocrinology 143(11):4304-9. [PubMed: 12399426]  [MGI Ref ID J:80469]

Lane PW. 1962. bg-beige and bg<2J> - beige-2J Mouse News Lett 26:35.  [MGI Ref ID J:65327]

Lane PW; Murphy ED. 1972. Susceptibility to spontaneous pneumonitis in an inbred strain of beige and satin mice. Genetics 72(3):451-60. [PubMed: 4643821]  [MGI Ref ID J:5311]

Marquis G; Montplaisir S; Pelletier M; Auger P; Lapp WS. 1988. Genetics of resistance to infection with Candida albicans in mice. Br J Exp Pathol 69(5):651-60. [PubMed: 3058198]  [MGI Ref ID J:27324]

Marquis G; Montplaisir S; Pelletier M; Mousseau S; Auger P. 1985. Genetic resistance to murine cryptococcosis: the beige mutation (Chediak-Higashi syndrome) in mice. Infect Immun 47(1):288-93. [PubMed: 3965401]  [MGI Ref ID J:147940]

Murphy ED; Roths JB. 1978. Purkinje cell degeneration, a late effect of beige mutations in mice Jackson Lab Ann Rep 49:108-9.  [MGI Ref ID J:15166]

Novak EK; Hui SW; Swank RT. 1984. Platelet storage pool deficiency in mouse pigment mutations associated with seven distinct genetic loci. Blood 63(3):536-44. [PubMed: 6696991]  [MGI Ref ID J:7327]

Paigen B; Holmes PA; Novak EK; Swank RT. 1990. Analysis of atherosclerosis susceptibility in mice with genetic defects in platelet function. Arteriosclerosis 10(4):648-52. [PubMed: 2369371]  [MGI Ref ID J:29748]

Pak MW; Giolli RA; Pinto LH; Mangini NJ; Gregory KM; Vanable JW Jr. 1987. Retinopretectal and accessory optic projections of normal mice and the OKN-defective mutant mice beige, beige-J, and pearl. J Comp Neurol 258(3):435-46. [PubMed: 3584547]  [MGI Ref ID J:29747]

Percy DH; Barta JR. 1993. Spontaneous and experimental infections in scid and scid/beige mice. Lab Anim Sci 43(2):127-32. [PubMed: 8320959]  [MGI Ref ID J:4752]

Perou CM; Leslie JD; Green W; Li L; Ward DM; Kaplan J. 1997. The Beige/Chediak-Higashi syndrome gene encodes a widely expressed cytosolic protein. J Biol Chem 272(47):29790-4. [PubMed: 9368050]  [MGI Ref ID J:44170]

Petrovan RJ; Yuan Y; Curtiss LK. 2008. Expression of the Lystbeige mutation is atheroprotective in chow-fed apolipoprotein E-deficient mice. J Lipid Res 49(2):429-37. [PubMed: 17982137]  [MGI Ref ID J:131876]

Prigent D; Trancart MM; Seed MP; Willoughby DA. 1996. Proteoglycan degrading activity in granulomatous inflammation: comparison between the C57b1/6 and C57bg/bg mouse. Inflamm Res 45(10):494-8. [PubMed: 8912013]  [MGI Ref ID J:36682]

Schiller NK; Black AS; Bradshaw GP; Bonnet DJ; Curtiss LK. 2004. Participation of macrophages in atherosclerotic lesion morphology in LDLr-/- mice. J Lipid Res 45(8):1398-409. [PubMed: 15175354]  [MGI Ref ID J:91367]

Schiller NK; Boisvert WA; Curtiss LK. 2002. Inflammation in atherosclerosis: lesion formation in LDL receptor-deficient mice with perforin and Lyst(beige) mutations. Arterioscler Thromb Vasc Biol 22(8):1341-6. [PubMed: 12171798]  [MGI Ref ID J:103214]

Shultz LD; Ishikawa F; Greiner DL. 2007. Humanized mice in translational biomedical research. Nat Rev Immunol 7(2):118-30. [PubMed: 17259968]  [MGI Ref ID J:142414]

Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York.  [MGI Ref ID J:78801]

Sundberg JP; Sundberg BA; Beamer WG. 1997. Comparison of chemical carcinogen skin tumor induction efficacy in inbred, mutant, and hybrid strains of mice: Morphologic variations of induced tumors and absence of a papillomavirus cocarcinogen. Mol Carcinog 20(1):19-32. [PubMed: 9328433]  [MGI Ref ID J:43880]

Trantow CM; Mao M; Petersen GE; Alward EM; Alward WL; Fingert JH; Anderson MG. 2009. Lyst mutation in mice recapitulates iris defects of human exfoliation syndrome. Invest Ophthalmol Vis Sci 50(3):1205-14. [PubMed: 19029039]  [MGI Ref ID J:173521]

Zen K; Guo YL; Li LM; Bian Z; Zhang CY; Liu Y. 2011. Cleavage of the CD11b extracellular domain by the leukocyte serprocidins is critical for neutrophil detachment during chemotaxis. Blood 117(18):4885-94. [PubMed: 21403131]  [MGI Ref ID J:173273]

Zhang H; Mahuran DJ; Callahan JW. 2010. Identification of proteins in the ceroid-like autofluorescent aggregates from liver lysosomes of Beige, a mouse model for human Chediak-Higashi syndrome. Mol Genet Metab 99(4):389-95. [PubMed: 20061169]  [MGI Ref ID J:158843]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX12

Colony Maintenance

Mating SystemHomozygote x Homozygote         (Female x Male)   26-DEC-07
Breeding Considerations This strain is a good breeder.
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $135.00Female or MaleHomozygous for Lystbg-J  
Price per Pair (US dollars $)Pair Genotype
$270.00Homozygous for Lystbg-J x Homozygous for Lystbg-J  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $175.50Female or MaleHomozygous for Lystbg-J  
Price per Pair (US dollars $)Pair Genotype
$351.00Homozygous for Lystbg-J x Homozygous for Lystbg-J  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

General Supply Notes

  • View the complete collection of spontaneous mutants in the Mouse Mutant Resource.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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