Description

Strain Information

Type Congenic; Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Background Strain C57BL/6J Donor Strain V H2 Haplotype b Generation N43 (11-JAN-08)

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Appearance
black, fat
Related Genotype: a/a Lep^ob/Lep^ob

black, lean
Related Genotype: a/a Lep^ob/+ or a/a ?/+

Description
Mice homozygous for the obese spontaneous mutation, (Lep^ob; commonly referred to as ob or ob/ob), are first recognizable at about four weeks of age. Homozygous mutant mice gain weight rapidly and may reach three times the normal weight of wild-type controls. In addition to obesity, mutant mice exhibit hyperphagia, a diabetes-like syndrome of hyperglycemia, glucose intolerance, elevated plasma insulin, subfertility, impaired wound healing, and an increase in hormone production from both pituitary and adrenal glands. They are also hypometabolic and hypothermic. The obesity is characterized by an increase in both adipocyte number and size. Although hyperphagia contributes to the obesity, homozygotes gain excess weight and deposit excess fat even when restricted to a diet sufficient for normal weight maintenance in lean mice. Hyperinsulinemia does not develop until after the increase in body weight, and probably results from it. Homozygotes have an abnormally low threshold for stimulation of pancreatic islet insulin secretion even in very young pre-obese animals. Female homozygotes exhibit decreased uterine and ovarian weights, decreased ovarian hormone production and hypercytolipidemia in follicular granulosa and endometrial epithelial tissue layers (Garris et al., 2004).

As is the case with mice carrying the diabetes mutation (Lepr^db), manifestation of the diabetic syndrome is strikingly dependent on genetic background. Hyperglycemia is only transient, (subsiding around 14 to 16 weeks) on the C57BL/6J background. On the C57BLKS background, obese homozygotes (Stock No. 000696) become severely diabetic with regression of islets and early death. Injection of recombinant leptin into obese homozygotes sharply reduces body weight, decreases food intake, increases energy expenditure, and restores fertility in male mice.

Leptin can regulate bone mass through a central, neuroendocrine signaling pathway. Similar to the effects of aging in humans, homozygotes exhibit muscle hypoplasia (quadriceps), increased marrow adipogenesis and decreased bone mass in the hindlimbs (Hamrick et al., 2004).

Control Information

	Control
	Heterozygote from the colony
	Untyped from the colony
	000664 C57BL/6J
Considerations for Choosing Controls

Related Strains

Strains carrying   Lep^ob allele

006906	B6.Cg-Lepob Ldlrtm1Her/J
000696	BKS.V-Lepob/J
004824	BTBR.V(B6)-Lepob/WiscJ

View Strains carrying   Lep^ob     (3 strains)

Additional Web Information

Genetic Quality Control Annual Report
JAX^® NOTES, Fall 1992; 451. Variation in the severity and duration of hyperglycemia in the C57BL/6J-ob/ob (obese) mouse.
JAX^® NOTES, Spring 2003; 489. Malocclusion in the Laboratory Mouse.
JAX^® NOTES, Summer 2003; 490. Hydrocephalus in Laboratory Mice.

Phenotype

Phenotype Information

View Phenotypic Data

Phenotypic Data

Body Weight Information - JAX^® Mice Strain B6.V-Lep^ob/J (000632)
(This chart reflects the typical correlation between body weight and age for mice maintained in production colonies at The Jackson Laboratory.)

Mouse Phenome Database

View Mammalian Phenotype Terms

Mammalian Phenotype Terms

      assigned by genotype

Lep^ob/Lep⁺

        involves: C57BL/6J

• skeleton phenotype
• increased bone mass (MGI Ref ID J:60001)
  • increased bone mass even on a low fat diet to delay obesity

Lep^ob/Lep^ob

        involves: C57BL/6J

• skeleton phenotype
• abnormal skeleton development (MGI Ref ID J:60001)
  • rate of new bone formation increased at both 3 and 6 months
• abnormal osteoclast differentiation (MGI Ref ID J:60001)
  • increased numbers of osteoclasts
• increased bone mass (MGI Ref ID J:60001)
  • denser vertebrae and long bones at 6 months
  • increased bone mass even on a low fat diet to delay obesity
• osteopetrosis (MGI Ref ID J:60001)
  • increased numbers of thick trabeculae at 3 and 6 months
  • 2 fold increase in trabecular bone volume
• homeostasis/metabolism phenotype
• increased circulating corticosterone level (MGI Ref ID J:60001)
  • severe
• hematopoietic system phenotype
• abnormal osteoclast differentiation (MGI Ref ID J:60001)
  • increased numbers of osteoclasts
• immune system phenotype
• abnormal osteoclast differentiation (MGI Ref ID J:60001)
  • increased numbers of osteoclasts

Lep^ob/Lep^ob

        B6.V-Lep^ob/J

• growth/size phenotype
• obese (MGI Ref ID J:104171)
  • 12-week old males are obese
  • develop progressive obesity
• homeostasis/metabolism phenotype
• abnormal circulating cholesterol level (MGI Ref ID J:18161)
• increased circulating cholesterol level (MGI Ref ID J:18161)
  • fasting plasma total cholesterol concentration is increased 2-3 fold over controls
• increased circulating HDL cholesterol level (MGI Ref ID J:18161)
• increased circulating LDL cholesterol level (MGI Ref ID J:18161)
• increased circulating VLDL cholesterol level (MGI Ref ID J:18161)
• decreased circulating glucose level (MGI Ref ID J:145998)
  • after feeding, serum glucose levels are more than 30% lower than in wild-type mice
• hyperglycemia (MGI Ref ID J:122746)
  • serum glucose is 320 mg/dl compared to 134 mg/dl in wild-type controls
• impaired glucose tolerance (MGI Ref ID J:104171)
  • glucose intolerance which improved when treated with rosiglitazone
  • following an acute intraperitoneal glucose injection, the post-challenge glucose level remained elevated up to 120 min compared to controls, indicating glucose intolerance
• increased circulating insulin level (MGI Ref ID J:104171)
  • seen in 12-week old males
  • serum insulin is 41.5 ng/ml compared to 0.8 ng/ml in wild-type
  • at 2 weeks, insulin levels are increased 2.5-fold compared to in wild-type mice
  • however, mice treated with isoproterenol exhibit lowered serum levels of insulin
• increased circulating triglyceride level (MGI Ref ID J:104171)
  • seen in 12-week old males
  • triglyceride levels are elevated 1.5- to 2-fold
• insulin resistance (MGI Ref ID J:104171)
• cardiovascular system phenotype
• abnormal myocardial fiber morphology (MGI Ref ID J:104171)
  • exhibit extensive focal damage in myocardial tissue, showing an abundance of lipid droplets in myocytes and damaged mitochondria that are swelled, have disorganized cristae and show loss of integrity
  • exhibit myocyte hypertrophy, with increased myocyte diameter and distorted nuclear architecture
• enlarged myocardial fiber (MGI Ref ID J:104171)
  • cardiomyocytes display larger resting cell length and cross-sectional area
• abnormal myocardial fiber physiology (MGI Ref ID J:104171)
  • cardiomyocytes exhibit decreased peak shortening and maximal velocity of shortening/relengthening, prolonged time-to-90% relengthening, reduced intracellular calcium release upon electrical stimulus associated with a slowed intracellular calcium decay rate, and significantly higher oxygen levels
• decreased cardiac muscle contractility (MGI Ref ID J:104171)
  • exhibit cardiac contractile dysfunction that is due to leptin deficiency and not obesity as high fat diet-induced obese controls show normal cardiomyocyte morphology and contractile function
• heart left ventricle hypertrophy (MGI Ref ID J:103063)
  • increase in left ventricle wall thickness and mass is seen by 6 months of age but not at 2 months of age
  • induced weight loss via leptin infusion, but not via caloric restriction, partially resolves the hypertrophy
• muscle phenotype
• abnormal myocardial fiber morphology (MGI Ref ID J:104171)
  • exhibit extensive focal damage in myocardial tissue, showing an abundance of lipid droplets in myocytes and damaged mitochondria that are swelled, have disorganized cristae and show loss of integrity
  • exhibit myocyte hypertrophy, with increased myocyte diameter and distorted nuclear architecture
• enlarged myocardial fiber (MGI Ref ID J:104171)
  • cardiomyocytes display larger resting cell length and cross-sectional area
• decreased cardiac muscle contractility (MGI Ref ID J:104171)
  • exhibit cardiac contractile dysfunction that is due to leptin deficiency and not obesity as high fat diet-induced obese controls show normal cardiomyocyte morphology and contractile function
• adipose tissue phenotype
• increased adipose tissue amount (MGI Ref ID J:122746)
  • mice have fat mass of ~42 g compared to ~3 g in wild-type at 16 weeks
• behavior/neurological phenotype
• abnormal food intake (MGI Ref ID J:122746)
• polyphagia (MGI Ref ID J:122746)
  • mice eat 70% more than wild-type controls
• hypoactivity (MGI Ref ID J:122746)
  • significantly reduced activity relative to wild-type controls
• reproductive system phenotype
• female infertility (MGI Ref ID J:122746)
  • females do not produce litters
• respiratory system phenotype
• lung inflammation (MGI Ref ID J:115772)
  • ozone induces significantly elevated levels of TNFR1
  • ozone induces a nonsignificant elevation of TNFR2 levels
• immune system phenotype
• decreased NK cell number (MGI Ref ID J:117826)
  • reduced numbers can be restored by treatment with leptin
• lung inflammation (MGI Ref ID J:115772)
  • ozone induces significantly elevated levels of TNFR1
  • ozone induces a nonsignificant elevation of TNFR2 levels
• tumorigenesis
• increased metastatic potential (MGI Ref ID J:117826)
  • increased metastasis to the lung of both melanoma cell lines and lung cancer cell lines initially injected in the tail vein
  • leptin reduces the level of metastasis
• hematopoietic system phenotype
• decreased NK cell number (MGI Ref ID J:117826)
  • reduced numbers can be restored by treatment with leptin
• digestive/alimentary phenotype
• decreased insulin secretion (MGI Ref ID J:145998)
  • leptin-treated islet cells exhibit decreased insulin secretion compared to similarly treated wild-type islets
• increased insulin secretion (MGI Ref ID J:145998)
  • insulin content in the pancreata is increased compared to in wild-type mice
• endocrine/exocrine gland phenotype
• decreased insulin secretion (MGI Ref ID J:145998)
  • leptin-treated islet cells exhibit decreased insulin secretion compared to similarly treated wild-type islets
• increased insulin secretion (MGI Ref ID J:145998)
  • insulin content in the pancreata is increased compared to in wild-type mice
• nervous system phenotype
• abnormal sympathetic nervous system physiology (MGI Ref ID J:145998)

Lep^ob/Lep^ob

        C57BL/6J-Lep^ob

• homeostasis/metabolism phenotype
• decreased circulating glucose level (MGI Ref ID J:129554)
  • when treated with AdipoR2-ASO, mice exhibit a decrease in plasma glucose level

Lep^ob/Lep^ob

        B6.V-Lep^ob/OlaHsd

• digestive/alimentary phenotype
• abnormal digestive system physiology (MGI Ref ID J:124815)
  • transepithelial resistance in the epithelium is reduced, indictive of a disrupted mucosal barrier function
• abnormal intestinal epithelium morphology (MGI Ref ID J:124815)
  • reduced levels of occludin in intestinal sections
  • zonula occludens 1 has a discontinuous distribution
• immune system phenotype
• abnormal acute inflammation (MGI Ref ID J:124815)
  • higher levels of endotoxin are found in portal blood (entotoxemia)
• increased susceptibility to endotoxin shock (MGI Ref ID J:124815)
  • increased succeptibility of hepatic stellate cells to LPS
• abnormal chemokine secretion (MGI Ref ID J:124815)
  • increased release of monocyte chemo attractant protein by hepatic stellate cells
• increased interleukin-6 secretion (MGI Ref ID J:124815)
  • increased release by hepatic stellate cells
• liver inflammation (MGI Ref ID J:124815)
• liver/biliary system phenotype
• liver inflammation (MGI Ref ID J:124815)

Lep^ob/Lep^ob

        B6.V-Lep^ob/JBomTac

• homeostasis/metabolism phenotype
• increased circulating triglyceride level (MGI Ref ID J:149091)
  • 3-fold

The following phenotype information may relate to a genetic background differing from this JAX^® Mice strain.

Lep^ob/Lep⁺

        involves: 129X1/SvJ * C57BL/6

• liver/biliary system phenotype
• increased liver weight (MGI Ref ID J:76479)
  • mice show significant increase in relative and absolute hepatic weight compared to wild-type; otherwise, no differences from wild-type are noted

Lep^ob/Lep^ob

        D2.B6-Lep^ob

• growth/size phenotype
• obese (MGI Ref ID J:78850)
• homeostasis/metabolism phenotype
• hyperglycemia (MGI Ref ID J:78850)
  • at 3 months of age, males are hyperglycemic with blood glucose levels of ~574 mg/dl; females have levels of ~388 mg/dl
• increased circulating insulin level (MGI Ref ID J:78850)
  • some mutant DBA/2J mice have high insulin levels compared to controls
• endocrine/exocrine gland phenotype
• abnormal pancreatic islet morphology (MGI Ref ID J:78850)
  • islets of mutants with low insulin levels are abnormal in appearance, being found in clusters of 1-4 cells, scattered within the ductal epithelium
• decreased pancreatic beta cell number (MGI Ref ID J:78850)
  • mutants with low insulin secretion have a low number of insulin-secreting cells compared to controls or high-insulin secreting mutants
• increased pancreatic beta cell number (MGI Ref ID J:78850)
  • there is a 5-fold increase in number of insulin-secreting cells per islet in obese mice with high insulin secretion
• digestive/alimentary phenotype
• abnormal pancreatic islet morphology (MGI Ref ID J:78850)
  • islets of mutants with low insulin levels are abnormal in appearance, being found in clusters of 1-4 cells, scattered within the ductal epithelium
• decreased pancreatic beta cell number (MGI Ref ID J:78850)
  • mutants with low insulin secretion have a low number of insulin-secreting cells compared to controls or high-insulin secreting mutants
• increased pancreatic beta cell number (MGI Ref ID J:78850)
  • there is a 5-fold increase in number of insulin-secreting cells per islet in obese mice with high insulin secretion

Lep^ob/Lep^ob

        FVB.B6-Lep^ob

• homeostasis/metabolism phenotype
• hyperglycemia (MGI Ref ID J:78850)
  • mice are hyperglycemic like congenic FVB Lepr mice
• increased circulating insulin level (MGI Ref ID J:78850)
  • mice are hyperinsulinemic like congenic FVB Lepr^db mice

Lep^ob/Lep^ob

        involves: 129X1/SvJ * C57BL/6

• growth/size phenotype
• decreased lean body mass (MGI Ref ID J:107169)
  • decreased (16.0 g, 33% of body weight) compared to wild-type (25.5 g 87% of body weight) or double mutants (19.8g)
• increased body weight (MGI Ref ID J:107169)
  • higher than wild-type
• homeostasis/metabolism phenotype
• abnormal circulating hormone level (MGI Ref ID J:76479)
• abnormal circulating pancreatic peptide level (MGI Ref ID J:76479)
  • plasma levels of pancreatic polypeptide (PP) are strongly reduced compared to wild-type
• decreased circulating testosterone level (MGI Ref ID J:76479)
  • level is markedly decreased compared to wild-type or Lep heterozygotes
  • significantly lower (4.2 nmol/l) compared to wild-type (14.2 nmol/l)
• increased circulating corticosterone level (MGI Ref ID J:76479)
  • mice display hypercorticosteronemia compared to wild-type
  • mice display hypercorticosteronemia compared to wild-type, Npy2r^tm1.1Hhz homozygotes, or Npy2r, Lep double mutants
• increased circulating insulin level (MGI Ref ID J:76479)
  • level is significantly increased over wild-type
  • hyperinsulinemic compared to wild-type
• increased circulating leptin level (MGI Ref ID J:76479)
  • level is significantly increased over wild-type
• hyperglycemia (MGI Ref ID J:107169)
• increased circulating cholesterol level (MGI Ref ID J:107169)
  • 5.74 mmol/l vs 3.54 mmol/l in wild-type
• increased circulating triglyceride level (MGI Ref ID J:107169)
  • 2.48 mmol/l vs 1.62 mmol/l in wild-type
• endocrine/exocrine gland phenotype
• abnormal branching of the mammary ductal tree (MGI Ref ID J:76479)
  • in virgin females, no ductal development occurs
• abnormal ovarian folliculogenesis (MGI Ref ID J:76479)
  • ovaries have very few primary or secondary follicles
• absent corpus luteum (MGI Ref ID J:76479)
  • no corpora lutea develops properly in ovary
• decreased seminal gland weight (MGI Ref ID J:76479)
  • weight of gland is significantly lower than wild-type or heterozygotes
• decreased testis weight (MGI Ref ID J:76479)
  • testis weight is significantly lower than in Lep^ob heterozygotes or Lep, Ppyr1 double null mice
  • testes weigh 0.19 g compared to 0.33 g in wild-type
• increased pancreas weight (MGI Ref ID J:107169)
  • 0.41 g vs 0.29 in wild-type
• adipose tissue phenotype
• abnormal adipose tissue amount (MGI Ref ID J:107169)
  • combined white adipose tissue (WAT) mass is increased compared to wild-type
• reproductive system phenotype
• abnormal branching of the mammary ductal tree (MGI Ref ID J:76479)
  • in virgin females, no ductal development occurs
• abnormal ovarian folliculogenesis (MGI Ref ID J:76479)
  • ovaries have very few primary or secondary follicles
• abnormal vagina opening (MGI Ref ID J:76479)
  • vaginal opening is very small compared to wild-type
• absent corpus luteum (MGI Ref ID J:76479)
  • no corpora lutea develops properly in ovary
• decreased seminal gland weight (MGI Ref ID J:76479)
  • weight of gland is significantly lower than wild-type or heterozygotes
• decreased testis weight (MGI Ref ID J:76479)
  • testis weight is significantly lower than in Lep^ob heterozygotes or Lep, Ppyr1 double null mice
  • testes weigh 0.19 g compared to 0.33 g in wild-type
• female infertility (MGI Ref ID J:76479)
  • homozygous females produce no litters
• male infertility (MGI Ref ID J:76479)
  • only one male tested was able to sire a litter
  • no males could produce offspring
• prolonged diestrus (MGI Ref ID J:76479)
  • mice have diestrous-like swab until 9 weeks of age
• prolonged estrous cycle (MGI Ref ID J:76479)
  • beginning at 9 weeks of age, estrous cycles last 11-15 days
• prolonged estrus (MGI Ref ID J:76479)
  • beginning at 9 weeks of age, estrous-like cytology lasts 6-8 days
• behavior/neurological phenotype
• polyphagia (MGI Ref ID J:107169)
• digestive/alimentary phenotype
• abnormal intestine morphology (MGI Ref ID J:107169)
  • mice display intestinal hypertrophy compared to wild-type mice (intestine weight - 1.89 g vs 1.03 g in wild-type; intestine length 43 cm vs 33 cm in wild-type)
• increased pancreas weight (MGI Ref ID J:107169)
  • 0.41 g vs 0.29 in wild-type
• liver/biliary system phenotype
• increased liver weight (MGI Ref ID J:107169)
  • 4.56 g vs 1.44 g in wild-type
• renal/urinary system phenotype
• increased kidney weight (MGI Ref ID J:107169)
  • 0.54 g vs 0.41 g in wild-type

Lep^ob/Lep^ob

        involves: 129/Sv * C57BL/6

• homeostasis/metabolism phenotype
• abnormal lipid level (MGI Ref ID J:121534)
  • sphingomeylin and antioxidant ethanolamine plasmlogen are markedly decreased
• increased circulating insulin level (MGI Ref ID J:121534)
  • at 4 and 16 weeks of age
• insulin resistance (MGI Ref ID J:121534)
  • at 16 weeks
• endocrine/exocrine gland phenotype
• abnormal pancreatic islet morphology (MGI Ref ID J:121534)
  • at 16 weeks, increased islet-to-pancreases volume ratios
  • at 16 weeks, islet insulin content is 30-fold greater than in Pparg^tm1Avb Lep^ob homozygotes
• enlarged pancreatic islets (MGI Ref ID J:121534)
• increased pancreatic islet number (MGI Ref ID J:121534)
• increased insulin secretion (MGI Ref ID J:121534)
  • at 16 weeks of age
• behavior/neurological phenotype
• hypoactivity (MGI Ref ID J:121534)
  • at 20 weeks, mice have decreased locomotor activity compared to wild-type
• polyphagia (MGI Ref ID J:121534)
  • hyperphagic
• growth/size phenotype
• increased body weight (MGI Ref ID J:121534)
  • mice quickly become heavier and have significantly elevated body weights at 4 and 6 weeks of age in females and males, respectively
• adipose tissue phenotype
• increased percent body fat (MGI Ref ID J:121534)
  • 40% increase compared to wild-type at 20 weeks
• liver/biliary system phenotype
• hepatic steatosis (MGI Ref ID J:121534)
• digestive/alimentary phenotype
• abnormal pancreatic islet morphology (MGI Ref ID J:121534)
  • at 16 weeks, increased islet-to-pancreases volume ratios
  • at 16 weeks, islet insulin content is 30-fold greater than in Pparg^tm1Avb Lep^ob homozygotes
• enlarged pancreatic islets (MGI Ref ID J:121534)
• increased pancreatic islet number (MGI Ref ID J:121534)
• increased insulin secretion (MGI Ref ID J:121534)
  • at 16 weeks of age

Lep^ob/Lep^ob

        BKS.V-Lep^ob/J

• homeostasis/metabolism phenotype
• abnormal circulating cholesterol level (MGI Ref ID J:18161)
• increased circulating cholesterol level (MGI Ref ID J:18161)
  • fasting plasma total cholesterol concentration is increased 2-3 fold over controls
• increased circulating HDL cholesterol level (MGI Ref ID J:18161)
• increased circulating LDL cholesterol level (MGI Ref ID J:18161)
• increased circulating VLDL cholesterol level (MGI Ref ID J:18161)
• increased circulating triglyceride level (MGI Ref ID J:18161)
  • triglyceride levels are elevated 1.5- to 2-fold

Genes & Alleles

Gene & Allele Information

Allele Symbol		Lepob
Allele Name		obese
Allele Type		Spontaneous
Common Name(s)		ob;
Strain of Origin		STOCK Mlph a Tgfa Cdh23 Ednrb
Gene Symbol and Name		Lep, leptin
Chromosome		6
Gene Common Name(s)		FLJ94114; OB; OBS; ob; obese;
General Note		Homozygous obese mice are first recognizable at about 4 weeks of age. They increase in weight rapidly and may reach three times normal weight (J:13066). In addition to obesity, mutant mice exhibit hyperphagia; a diabetes-like syndrome of hyperglycemia, glucose intolerance, and elevated plasma insulin; subfertility; and increased hormone production from both pituitary and adrenal. They also have difficulty maintaining body temperature under cold conditions (J:7702). The obesity is characterized by both an increased number of adipocytes and an increase in their size (J:7702); this is in contrast to other genetic obesities in the mouse in which increase in fat depots is due entirely to cell enlargement (J:5253, J:5765). Hyperphagia may contribute tothe obesity. However, homozygotes gain excess weight and deposit excess fat even when restricted to a diet sufficient for normal lean mice, thus demonstrating an increased metabolic efficiency (J:6236). In parabiosis with normal mice, Lepob homozygotes eat less and lose weight; in parabiosis with Leprdb homozygotes, they cease eating completely and die of starvation. This is taken to mean that they have a normal response to a 'satiety' factor, presumably the leptin protein, but are unable to produce enough of it to maintain normal food intake (J:5401). Hyperinsulinemia does not develop until after the increase in food intake and is probably the result of it (J:5759). It has been shown, however, that homozygous Lepob mice have an abnormally low threshold for stimulation of pancreatic islet insulin secretion (J:14402), even in very young animals before obesity develops (J:22634). As is the case with the diabetes mutant Leprdb, manifestation of the diabetic syndrome is strikingly dependent on genetic background. On a C57BL/6 background, Lepob homozygotes develop a well compensated diabetes with only temporary and moderate hyperglycemia, marked hyperinsulinemia, and enlarged islets of Langerhans. Onthe C57BLKS background, however, they become severely diabetic with regression of the islets and early death (J:5400). Lepob homozygous mice have an impaired capacity for non-shivering thermogenesis which can be demonstrated at low temperatures as early as 10 days of age (J:12010). At 4 degrees C they rapidly become hypothermic and die within a few hours (J:5958). It has been suggested that a reduction in the energy requirement normally used for thermoregulatory heat production could be responsible for the increased metabolic efficiency noted above. That is unlikely to be the major cause of the thermoregulatory problems, however, since brief exposure of obese mice to 10 degrees C produces cold adaptation and allows indefinite survival at 4degrees C with maintenance of nearly normal body temperature (J:6756). Coleman has suggested that the hyperinsulinemia of obese mice, which increases synthetic processes and decreases degradation, might spare the energy normally spent on tissue turnover and account at least in part for the increased efficiency (J:6756). Some contribution to the effect may also come from a low basal Na+,K+ATPase activity, shown to occur in muscle of 14-day old mutants (J:6182). Heterozygotes (Lepob/+) have normal body weight, blood glucose, and plasma insulin, but can survive a prolonged fast longer than congenic wild-type controls, suggesting that increased metabolic efficiency is expressed to some extent in heterozygotes (J:159). Female homozygotes are always sterile, although their ovaries respond to exogenous pituitary hormones. About 20% of male homozygotes may be transiently fertile, particularly if maintained on a restricted diet (J:7702). Cloning of the Lep gene has made possible the production of recombinant leptin. Injection of this protein into Lepob homozygotes sharply reduces body weight, decreases food intake, and increases energy expenditure. There is no effect in diabetic Leprdb homozygotes, who are resistant to effects of the Lepob mutation. Normal mice also decrease food consumption and lose weight, with an accompanying loss in body fat (J:29161). Other investigators have obtained congruent results in normal and in Lepob mice (J:29162, J:29075); leptin also reduces food intake in fasted normal mice (J:28578). Leptin treatment effects on behavior of Lepob mice suggest a direct effect on neuronal networks (J:29160). Interactions of leptin with effects of hypothalamic lesions and of the Lepr gene indicate that Lep is upstream in the pathway of adipose tissue mass regulation (J:27422). Mutant leptin produced by the Lepob mutation fails to self-regulate production of leptin mRNA, which rises to a level 4 times that in normal mice. Lean mice when fasted decrease in leptin mRNA levels, but obese animals do not (J:29081). There is a vast literature on the biochemical and physiological changes in Lepob mice, which has been reviewed by Herberg and Coleman (J:5759) and more recently by Charlton (J:7702). Many of the studies performed in adult mice may involve secondary effects of obesity rather than primary causes of it. Increased blood levels of corticosterone occur in Lepob/Lepob mice, and most of the symptoms of the obese syndrome are ameliorated by excision of the adrenal glands. The hypothalamus-pituitary-adrenal axis is dysregulated, with hyperactivity of pituitary synthesis and secretion of adrenocorticotropic hormone (ACTH), as well as hyperresponsiveness of the adrenal cortex to ACTH (J:13151). Adrenal medullary activity, on the other hand, may be decreased; a diminished urinary excretion of epinephrine in obese homozygous mice indicates reduced medullary production, although this may be a secondary effect of the obesity (J:4033). A low serum level of the thyroid hormone triiodothyronine (T3) is also characteristic of obese homozygotes. Early treatment of these mice with T3 increases oxygen consumption and temperature while reducing body fat (J:22025). T3 treatment increases oxidative metabolism in muscle, but not in brown adipose tissue or in liver (J:22377). Plasma triglyceride levels are elevated in mouse mutants considered models of non-insulin-dependent diabetes,including Lepob mutants. Cholesterol is also elevated, but the increase is primarily in high-density lipoprotein cholesterol (J:18161), so that atherosclerotic lesions are not increased (J:19043).
Molecular Note		Sequencing of RT-PCR products revealed a nonsense mutation in codon 105 resulting from a C to T point mutation. The 16 kDa leptin protein, expressed predominantly in adipose tissue of normal mice, is missing from homozygous mutant mice (J:29081). [MGI Ref ID J:20512] [MGI Ref ID J:29081] [MGI Ref ID J:45748]

Genotyping

Genotyping Information

Genotyping Protocols

Lep^ob, PYRO, vers. 2
Lep^ob, REST, vers. 1

Helpful Links

Genotyping resources and troubleshooting

References

References

Selected Reference(s)

Coleman DL; Hummel KP. 1973. The influence of genetic background on the expression of the obese (Ob) gene in the mouse. Diabetologia 9(4):287-93. [PubMed: 4588246]  [MGI Ref ID J:5400]

Ewart-Toland A; Mounzih K; Qiu J; Chehab FF. 1999. Effect of the genetic background on the reproduction of leptin-deficient obese mice. Endocrinology 140(2):732-8. [PubMed: 9927300]  [MGI Ref ID J:52903]

Fantuzzi G; Faggioni R. 2000. Leptin in the regulation of immunity, inflammation, and hematopoiesis. J Leukoc Biol 68(4):437-46. [PubMed: 11037963]  [MGI Ref ID J:109886]

Malik NM; Carter ND; Murray JF; Scaramuzzi RJ; Wilson CA; Stock MJ. 2001. Leptin requirement for conception, implantation, and gestation in the mouse. Endocrinology 142(12):5198-202. [PubMed: 11713215]  [MGI Ref ID J:94783]

Mancuso P; Gottschalk A; Phare SM; Peters-Golden M; Lukacs NW; Huffnagle GB. 2002. Leptin-deficient mice exhibit impaired host defense in gram-negative pneumonia. J Immunol 168(8):4018-24. [PubMed: 11937559]  [MGI Ref ID J:75906]

Oler AT; Attie AD. 2008. A rapid, microplate SNP genotype assay for the leptinob allele. J Lipid Res 49(5):1126-9. [PubMed: 18272929]  [MGI Ref ID J:133040]

Sanna V; Di Giacomo A; La Cava A; Lechler RI; Fontana S; Zappacosta S; Matarese G. 2003. Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses. J Clin Invest 111(2):241-50. [PubMed: 12531880]  [MGI Ref ID J:81413]

Siegmund B; Lehr HA; Fantuzzi G. 2002. Leptin: a pivotal mediator of intestinal inflammation in mice. Gastroenterology 122(7):2011-25. [PubMed: 12055606]  [MGI Ref ID J:109852]

Zhang Y; Proenca R; Maffei M; Barone M; Leopold L; Friedman JM. 1994. Positional cloning of the mouse obese gene and its human homologue [published erratum appears in Nature 1995 Mar 30;374(6521):479] [see comments] Nature 372(6505):425-32. [PubMed: 7984236]  [MGI Ref ID J:20512]

Additional References

Anini Y; Brubaker PL. 2003. Role of leptin in the regulation of glucagon-like peptide-1 secretion. Diabetes 52(2):252-9. [PubMed: 12540594]  [MGI Ref ID J:94640]

Arvaniti K; Huang Q; Richard D. 2001. Effects of Leptin and Corticosterone on the Expression of Corticotropin-Releasing Hormone, Agouti-Related Protein, and Proopiomelanocortin in the Brain of ob/ob Mouse. Neuroendocrinology 73(4):227-36. [PubMed: 11340336]  [MGI Ref ID J:69137]

Boundy VA; Cincotta AH. 2000. Hypothalamic adrenergic receptor changes in the metabolic syndrome of genetically obese (ob/ob) mice. Am J Physiol Regul Integr Comp Physiol 279(2):R505-14. [PubMed: 10938239]  [MGI Ref ID J:94672]

Campfield LA; Smith FJ; Guisez Y; Devos R; Burn P. 1995. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks [see comments] Science 269(5223):546-9. [PubMed: 7624778]  [MGI Ref ID J:29160]

Charlton HM. 1984. Mouse mutants as models in endocrine research. Q J Exp Physiol 69(4):655-76. [PubMed: 6393185]  [MGI Ref ID J:7702]

Cheng A; Uetani N; Simoncic PD; Chaubey VP; Lee-Loy A; McGlade CJ; Kennedy BP; Tremblay ML. 2002. Attenuation of Leptin Action and Regulation of Obesity by Protein Tyrosine Phosphatase 1B. Dev Cell 2(4):497-503. [PubMed: 11970899]  [MGI Ref ID J:75969]

Chiu CH; Lin WD; Huang SY; Lee YH. 2004. Effect of a C/EBP gene replacement on mitochondrial biogenesis in fat cells. Genes Dev 18(16):1970-5. [PubMed: 15289464]  [MGI Ref ID J:91840]

Cleary MP; Phillips FC; Getzin SC; Jacobson TL; Jacobson MK; Christensen TA; Juneja SC; Grande JP; Maihle NJ. 2003. Genetically obese MMTV-TGF-alpha/Lep(ob)Lep(ob) female mice do not develop mammary tumors. Breast Cancer Res Treat 77(3):205-15. [PubMed: 12602920]  [MGI Ref ID J:81933]

Coleman DL. 1973. Effects of parabiosis of obese with diabetes and normal mice. Diabetologia 9(4):294-8. [PubMed: 4767369]  [MGI Ref ID J:5401]

Coleman DL. 1982. Thermogenesis in diabetes-obesity syndromes in mutant mice. Diabetologia 22(3):205-11. [PubMed: 7075918]  [MGI Ref ID J:6756]

Di Marzo V; Goparaju SK; Wang L; Liu J; Batkai S; Jarai Z; Fezza F; Miura GI; Palmiter RD; Sugiura T; Kunos G. 2001. Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature 410(6830):822-5. [PubMed: 11298451]  [MGI Ref ID J:68834]

Erickson JC; Hollopeter G; Palmiter RD. 1996. Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science 274(5293):1704-7. [PubMed: 8939859]  [MGI Ref ID J:37106]

Goren I; Kampfer H; Podda M; Pfeilschifter J; Frank S. 2003. Leptin and wound inflammation in diabetic ob/ob mice: differential regulation of neutrophil and macrophage influx and a potential role for the scab as a sink for inflammatory cells and mediators. Diabetes 52(11):2821-32. [PubMed: 14578302]  [MGI Ref ID J:86305]

Guo L; Munzberg H; Stuart RC; Nillni EA; Bjorbaek C. 2004. N-acetylation of hypothalamic alpha-melanocyte-stimulating hormone and regulation by leptin. Proc Natl Acad Sci U S A 101(32):11797-802. [PubMed: 15280541]  [MGI Ref ID J:91785]

Halaas JL; Gajiwala KS; Maffei M; Cohen SL; Chait BT; Rabinowitz D; Lallone RL; Burley SK; Friedman JM. 1995. Weight-reducing effects of the plasma protein encoded by the obese gene [see comments] Science 269(5223):543-6. [PubMed: 7624777]  [MGI Ref ID J:29161]

Haluzik M; Colombo C; Gavrilova O; Chua S; Wolf N; Chen M; Stannard B; Dietz KR; Le Roith D; Reitman ML. 2004. Genetic background (C57BL/6J versus FVB/N) strongly influences the severity of diabetes and insulin resistance in ob/ob mice. Endocrinology 145(7):3258-64. [PubMed: 15059949]  [MGI Ref ID J:90742]

Hamrick MW; Pennington C; Newton D; Xie D; Isales C. 2004. Leptin deficiency produces contrasting phenotypes in bones of the limb and spine. Bone 34(3):376-83. [PubMed: 15003785]  [MGI Ref ID J:88559]

Herberg L; Coleman DL. 1977. Laboratory animals exhibiting obesity and diabetes syndromes. Metabolism 26(1):59-99. [PubMed: 834144]  [MGI Ref ID J:5759]

Hochgeschwender U; Costa JL; Reed P; Bui S; Brennan MB. 2003. Altered glucose homeostasis in proopiomelanocortin-null mouse mutants lacking central and peripheral melanocortin. Endocrinology 144(12):5194-202. [PubMed: 12970157]  [MGI Ref ID J:87246]

Hyogo H; Roy S; Paigen B; Cohen DE. 2002. Leptin Promotes Biliary Cholesterol Elimination during Weight Loss in ob/ob Mice by Regulating the Enterohepatic Circulation of Bile Salts. J Biol Chem 277(37):34117-24. [PubMed: 12114517]  [MGI Ref ID J:78952]

Kaplan ML; Trout JR; Leveille GA. 1976. Adipocyte size distribution in ob/ob mice during preobese and obese phases of development. Proc Soc Exp Biol Med 153(3):476-82. [PubMed: 1013161]  [MGI Ref ID J:5765]

Ke Y; Qiu J; Ogus S; Shen WJ; Kraemer FB; Chehab FF. 2003. Overexpression of leptin in transgenic mice leads to decreased basal lipolysis, PKA activity, and perilipin levels. Biochem Biophys Res Commun 312(4):1165-70. [PubMed: 14651995]  [MGI Ref ID J:94674]

Kumano S; Matsumoto H; Takatsu Y; Noguchi J; Kitada C; Ohtaki T. 2003. Changes in hypothalamic expression levels of galanin-like Peptide in rat and mouse models support that it is a leptin-target Peptide. Endocrinology 144(6):2634-43. [PubMed: 12746327]  [MGI Ref ID J:83523]

Laustsen PG; Michael MD; Crute BE; Cohen SE; Ueki K; Kulkarni RN; Keller SR; Lienhard GE; Kahn CR. 2002. Lipoatrophic diabetes in Irs1(-/-)/Irs3(-/-) double knockout mice. Genes Dev 16(24):3213-22. [PubMed: 12502742]  [MGI Ref ID J:80976]

Li Z; Lin H; Yang S; Diehl AM. 2002. Murine leptin deficiency alters Kupffer cell production of cytokines that regulate the innate immune system. Gastroenterology 123(4):1304-10. [PubMed: 12360490]  [MGI Ref ID J:79334]

Liang CP; Tall AR. 2001. Transcriptional Profiling Reveals Global Defects in Energy Metabolism, Lipoprotein, and Bile Acid Synthesis and Transport with Reversal by Leptin Treatment in Ob/ob Mouse Liver. J Biol Chem 276(52):49066-76. [PubMed: 11551957]  [MGI Ref ID J:73512]

Liu Y; Nakagawa Y; Wang Y; Li R; Li X; Ohzeki T; Friedman TC. 2003. Leptin activation of corticosterone production in hepatocytes may contribute to the reversal of obesity and hyperglycemia in leptin-deficient ob/ob mice. Diabetes 52(6):1409-16. [PubMed: 12765951]  [MGI Ref ID J:83537]

MacDougald OA; Hwang CS; Fan H; Lane MD. 1995. Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes. Proc Natl Acad Sci U S A 92(20):9034-7. [PubMed: 7568067]  [MGI Ref ID J:29081]

Makimura H; Mizuno TM; Roberts J; Silverstein J; Beasley J; Mobbs CV. 2000. Adrenalectomy reverses obese phenotype and restores hypothalamic melanocortin tone in leptin-deficient ob/ob mice Diabetes 49(11):1917-23. [PubMed: 11078460]  [MGI Ref ID J:65482]

Matsusue K; Haluzik M; Lambert G; Yim SH; Gavrilova O; Ward JM; Brewer B Jr; Reitman ML; Gonzalez FJ. 2003. Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes. J Clin Invest 111(5):737-47. [PubMed: 12618528]  [MGI Ref ID J:82439]

Matsuzaka T; Shimano H; Yahagi N; Yoshikawa T; Amemiya-Kudo M; Hasty AH; Okazaki H; Tamura Y; Iizuka Y; Ohashi K; Osuga J; Takahashi A; Yato S; Sone H; Ishibashi S; Yamada N. 2002. Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs. J Lipid Res 43(6):911-20. [PubMed: 12032166]  [MGI Ref ID J:76920]

McPherron AC; Lee SJ. 2002. Suppression of body fat accumulation in myostatin-deficient mice. J Clin Invest 109(5):595-601. [PubMed: 11877467]  [MGI Ref ID J:75344]

Memon RA; Tecott LH; Nonogaki K; Beigneux A; Moser AH; Grunfeld C; Feingold KR. 2000. Up-regulation of peroxisome proliferator-activated receptors (PPAR-alpha) and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity: troglitazone induces expression of PPAR-gamma-responsive adipose tissue-specific genes in the liver of obese diabetic mice [In Process Citation] Endocrinology 141(11):4021-31. [PubMed: 11089532]  [MGI Ref ID J:65569]

Muurling M; van den Hoek AM; Mensink RP; Pijl H; Romijn JA; Havekes LM; Voshol PJ. 2004. Overexpression of APOC1 in obob mice leads to hepatic steatosis and severe hepatic insulin resistance. J Lipid Res 45(1):9-16. [PubMed: 14523051]  [MGI Ref ID J:87976]

Nishina PM; Lowe S; Wang J; Paigen B. 1994. Characterization of plasma lipids in genetically obese mice: the mutants obese, diabetes, fat, tubby, and lethal yellow. Metabolism 43(5):549-53. [PubMed: 8177042]  [MGI Ref ID J:18161]

Pelleymounter MA; Cullen MJ; Baker MB; Hecht R; Winters D; Boone T; Collins F. 1995. Effects of the obese gene product on body weight regulation in ob/ob mice [see comments] Science 269(5223):540-3. [PubMed: 7624776]  [MGI Ref ID J:29162]

Perreault M; Marette A. 2001. Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle. Nat Med 7(10):1138-43. [PubMed: 11590438]  [MGI Ref ID J:72215]

Polotsky VY; Wilson JA; Smaldone MC; Haines AS; Hurn PD; Tankersley CG; Smith PL; Schwartz AR; O'Donnell CP. 2001. Female gender exacerbates respiratory depression in leptin-deficient obesity. Am J Respir Crit Care Med 164(8 Pt 1):1470-5. [PubMed: 11704598]  [MGI Ref ID J:94673]

Rondinone CM; Clampit J; Gum RJ; Zinker BA; Jirousek MR; Trevillyan JM. 2004. Reduction of PTP1B induces differential expression of PI3-kinase (p85alpha) isoforms. Biochem Biophys Res Commun 323(2):652-9. [PubMed: 15369800]  [MGI Ref ID J:92476]

Sekiya M; Osuga J; Okazaki H; Yahagi N; Harada K; Shen WJ; Tamura Y; Tomita S; Iizuka Y; Ohashi K; Okazaki M; Sata M; Nagai R; Fujita T; Shimano H; Kraemer FB; Yamada N; Ishibashi S. 2004. Absence of hormone-sensitive lipase inhibits obesity and adipogenesis in Lep ob/ob mice. J Biol Chem 279(15):15084-90. [PubMed: 14752112]  [MGI Ref ID J:89519]

Sjoholm A; Arkhammar P; Berggren PO; Andersson A. 2001. Polyamines in pancreatic islets of obese-hyperglycemic (ob/ob) mice of different ages. Am J Physiol Cell Physiol 280(2):C317-23. [PubMed: 11208527]  [MGI Ref ID J:68066]

Stoehr JP; Nadler ST; Schueler KL; Rabaglia ME; Yandell BS; Metz SA; Attie AD. 2000. Genetic obesity unmasks nonlinear interactions between murine type 2 diabetes susceptibility loci Diabetes 49(11):1946-54. [PubMed: 11078464]  [MGI Ref ID J:65486]

Takeda S; Elefteriou F; Levasseur R; Liu X; Zhao L; Parker KL; Armstrong D; Ducy P; Karsenty G. 2002. Leptin regulates bone formation via the sympathetic nervous system. Cell 111(3):305-17. [PubMed: 12419242]  [MGI Ref ID J:79873]

Trayhurn P; James WP. 1978. Thermoregulation and non-shivering thermogenesis in the genetically obese (ob/ob) mouse. Pflugers Arch 373(2):189-93. [PubMed: 565045]  [MGI Ref ID J:5958]

Trayhurn P; Thurlby PL; James WP. 1977. Thermogenic defect in pre-obese ob/ob mice. Nature 266(5597):60-2. [PubMed: 840297]  [MGI Ref ID J:12010]

Tritos NA; Mastaitis JW; Kokkotou E; Maratos-Flier E. 2001. Characterization of melanin concentrating hormone and preproorexin expression in the murine hypothalamus. Brain Res 895(1-2):160-6. [PubMed: 11259773]  [MGI Ref ID J:68391]

Tsuruta Y; Yoshimatsu H; Hidaka S; Kondou S; Okamoto K; Sakata T. 2002. Hyperleptinemia in A(y)/a mice upregulates arcuate cocaine- and amphetamine-regulated transcript expression. Am J Physiol Endocrinol Metab 282(4):E967-73. [PubMed: 11882520]  [MGI Ref ID J:75872]

Xia Z; Sniderman AD; Cianflone K. 2002. Acylation-stimulating Protein (ASP) Deficiency Induces Obesity Resistance and Increased Energy Expenditure in ob/ob Mice. J Biol Chem 277(48):45874-9. [PubMed: 12244109]  [MGI Ref ID J:80546]

Xu J; Wang P; Li Y; Li G; Kaczmarek LK; Wu Y; Koni PA; Flavell RA; Desir GV. 2004. The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity. Proc Natl Acad Sci U S A 101(9):3112-7. [PubMed: 14981264]  [MGI Ref ID J:88651]

Yahagi N; Shimano H; Hasty AH; Matsuzaka T; Ide T; Yoshikawa T; Amemiya-Kudo M; Tomita S; Okazaki H; Tamura Y; Iizuka Y; Ohashi K; Osuga J; Harada K; Gotoda T; Nagai R; Ishibashi S; Yamada N. 2002. Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice. J Biol Chem 277(22):19353-7. [PubMed: 11923308]  [MGI Ref ID J:76758]

Yamamoto K; Shimokawa T; Yi H; Isobe K; Kojima T; Loskutoff DJ; Saito H. 2002. Aging and obesity augment the stress-induced expression of tissue factor gene in the mouse. Blood 100(12):4011-8. [PubMed: 12393670]  [MGI Ref ID J:80526]

Yang S; Lin HZ; Hwang J; Chacko VP; Diehl AM. 2001. Hepatic hyperplasia in noncirrhotic fatty livers: is obesity-related hepatic steatosis a premalignant condition? Cancer Res 61(13):5016-23. [PubMed: 11431335]  [MGI Ref ID J:70169]

Zvonic S; Cornelius P; Stewart WC; Mynatt RL; Stephens JM. 2003. The regulation and activation of ciliary neurotrophic factor signaling proteins in adipocytes. J Biol Chem 278(4):2228-35. [PubMed: 12424252]  [MGI Ref ID J:81732]

Lep^ob related

Abe KC; Mori MA; Pesquero JB. 2007. Leptin deficiency leads to the regulation of kinin receptors expression in mice. Regul Pept 138(2-3):56-8. [PubMed: 17184856]  [MGI Ref ID J:137078]

Ablamunits V; Cohen Y; Brazee IB; Gaetz HP; Vinson C; Klebanov S. 2006. Susceptibility to Induced and Spontaneous Carcinogenesis Is Increased in Fatless A-ZIP/F-1 but not in Obese ob/ob Mice. Cancer Res 66(17):8897-902. [PubMed: 16951207]  [MGI Ref ID J:112412]

Ahima RS; Prabakaran D; Flier JS. 1998. Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding. Implications for energy homeostasis and neuroendocrine function. J Clin Invest 101(5):1020-7. [PubMed: 9486972]  [MGI Ref ID J:118976]

Akpinar P; Kuwajima S; Krutzfeldt J; Stoffel M. 2005. Tmem27: a cleaved and shed plasma membrane protein that stimulates pancreatic beta cell proliferation. Cell Metab 2(6):385-97. [PubMed: 16330324]  [MGI Ref ID J:129667]

Albarado DC; McClaine J; Stephens JM; Mynatt RL; Ye J; Bannon AW; Richards WG; Butler AA. 2004. Impaired coordination of nutrient intake and substrate oxidation in melanocortin-4 receptor knockout mice. Endocrinology 145(1):243-52. [PubMed: 14551222]  [MGI Ref ID J:96671]

Alberts P; Nilsson C; Selen G; Engblom LO; Edling NH; Norling S; Klingstrom G; Larsson C; Forsgren M; Ashkzari M; Nilsson CE; Fiedler M; Bergqvist E; Ohman B; Bjorkstrand E; Abrahmsen LB. 2003. Selective inhibition of 11 beta-hydroxysteroid dehydrogenase type 1 improves hepatic insulin sensitivity in hyperglycemic mice strains. Endocrinology 144(11):4755-62. [PubMed: 12960099]  [MGI Ref ID J:87239]

Allen DL; Cleary AS; Speaker KJ; Lindsay SF; Uyenishi J; Reed JM; Madden MC; Mehan RS. 2008. Myostatin, activin receptor IIb, and follistatin-like-3 gene expression are altered in adipose tissue and skeletal muscle of obese mice. Am J Physiol Endocrinol Metab 294(5):E918-27. [PubMed: 18334608]  [MGI Ref ID J:135996]

Alon T; Friedman JM. 2006. Late-onset leanness in mice with targeted ablation of melanin concentrating hormone neurons. J Neurosci 26(2):389-97. [PubMed: 16407534]  [MGI Ref ID J:104264]

Altarejos JY; Goebel N; Conkright MD; Inoue H; Xie J; Arias CM; Sawchenko PE; Montminy M. 2008. The Creb1 coactivator Crtc1 is required for energy balance and fertility. Nat Med 14(10):1112-7. [PubMed: 18758446]  [MGI Ref ID J:142448]

Anand A; Chada K. 2000. In vivo modulation of Hmgic reduces obesity. Nat Genet 24(4):377-80. [PubMed: 10742101]  [MGI Ref ID J:61493]

Aouadi M; Laurent K; Prot M; Le Marchand-Brustel Y; Binetruy B; Bost F. 2006. Inhibition of p38MAPK increases adipogenesis from embryonic to adult stages. Diabetes 55(2):281-9. [PubMed: 16443758]  [MGI Ref ID J:106432]

Ariyasu H; Takaya K; Hosoda H; Iwakura H; Ebihara K; Mori K; Ogawa Y; Hosoda K; Akamizu T; Kojima M; Kangawa K; Nakao K. 2002. Delayed short-term secretory regulation of ghrelin in obese animals: evidenced by a specific RIA for the active form of ghrelin. Endocrinology 143(9):3341-50. [PubMed: 12193546]  [MGI Ref ID J:81463]

Arvaniti K; Huang Q; Richard D. 2001. Effects of Leptin and Corticosterone on the Expression of Corticotropin-Releasing Hormone, Agouti-Related Protein, and Proopiomelanocortin in the Brain of ob/ob Mouse. Neuroendocrinology 73(4):227-36. [PubMed: 11340336]  [MGI Ref ID J:69137]

Asakawa A; Inui A; Ueno N; Makino S; Fujino MA; Kasuga M. 1999. Urocortin reduces food intake and gastric emptying in lean and ob/ob obese mice [see comments] Gastroenterology 116(6):1287-92. [PubMed: 10348810]  [MGI Ref ID J:57224]

Atkinson RD; Coenen KR; Plummer MR; Gruen ML; Hasty AH. 2008. Macrophage-derived apolipoprotein E ameliorates dyslipidemia and atherosclerosis in obese apolipoprotein E-deficient mice. Am J Physiol Endocrinol Metab 294(2):E284-90. [PubMed: 18029445]  [MGI Ref ID J:133332]

Back M; Sultan A; Ovchinnikova O; Hansson GK. 2007. 5-Lipoxygenase-activating protein: a potential link between innate and adaptive immunity in atherosclerosis and adipose tissue inflammation. Circ Res 100(7):946-9. [PubMed: 17379835]  [MGI Ref ID J:133901]

Baffy G; Zhang CY; Glickman JN; Lowell BB. 2002. Obesity-related fatty liver is unchanged in mice deficient for mitochondrial uncoupling protein 2. Hepatology 35(4):753-61. [PubMed: 11915020]  [MGI Ref ID J:106023]

Baldock PA; Allison S; McDonald MM; Sainsbury A; Enriquez RF; Little DG; Eisman JA; Gardiner EM; Herzog H. 2006. Hypothalamic regulation of cortical bone mass: opposing activity of Y2 receptor and leptin pathways. J Bone Miner Res 21(10):1600-7. [PubMed: 16995815]  [MGI Ref ID J:128105]

Baldock PA; Sainsbury A; Allison S; Lin EJ; Couzens M; Boey D; Enriquez R; During M; Herzog H; Gardiner EM. 2005. Hypothalamic control of bone formation: distinct actions of leptin and y2 receptor pathways. J Bone Miner Res 20(10):1851-7. [PubMed: 16160743]  [MGI Ref ID J:128137]

Bandsma RH; Grefhorst A; van Dijk TH; van der Sluijs FH; Hammer A; Reijngoud DJ; Kuipers F. 2004. Enhanced glucose cycling and suppressed de novo synthesis of glucose-6-phosphate result in a net unchanged hepatic glucose output in ob/ob mice. Diabetologia 47(11):2022-31. [PubMed: 15599701]  [MGI Ref ID J:107197]

Barouch LA; Berkowitz DE; Harrison RW; O'Donnell CP; Hare JM. 2003. Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice. Circulation 108(6):754-9. [PubMed: 12885755]  [MGI Ref ID J:103063]

Barouch LA; Gao D; Chen L; Miller KL; Xu W; Phan AC; Kittleson MM; Minhas KM; Berkowitz DE; Wei C; Hare JM. 2006. Cardiac myocyte apoptosis is associated with increased DNA damage and decreased survival in murine models of obesity. Circ Res 98(1):119-24. [PubMed: 16339484]  [MGI Ref ID J:118064]

Batra A; Pietsch J; Fedke I; Glauben R; Okur B; Stroh T; Zeitz M; Siegmund B. 2007. Leptin-dependent toll-like receptor expression and responsiveness in preadipocytes and adipocytes. Am J Pathol 170(6):1931-41. [PubMed: 17525261]  [MGI Ref ID J:122150]

Begin-Heick N. 1994. Liver beta-adrenergic receptors, G proteins, and adenylyl cyclase activity in obesity-diabetes syndromes. Am J Physiol 266(6 Pt 1):C1664-72. [PubMed: 8023896]  [MGI Ref ID J:18963]

Begriche K; Letteron P; Abbey-Toby A; Vadrot N; Robin MA; Bado A; Pessayre D; Fromenty B. 2008. Partial leptin deficiency favors diet-induced obesity and related metabolic disorders in mice. Am J Physiol Endocrinol Metab 294(5):E939-51. [PubMed: 18349116]  [MGI Ref ID J:136084]

Berk PD; Zhou S; Kiang C; Stump DD; Fan X; Bradbury MW. 1999. Selective up-regulation of fatty acid uptake by adipocytes characterizes both genetic and diet-induced obesity in rodents. J Biol Chem 274(40):28626-31. [PubMed: 10497230]  [MGI Ref ID J:57965]

Bhat GK; Hamm ML; Igietseme JU; Mann DR. 2003. Does leptin mediate the effect of photoperiod on immune function in mice? Biol Reprod 69(1):30-6. [PubMed: 12606383]  [MGI Ref ID J:84031]

Biddinger SB; Miyazaki M; Boucher J; Ntambi JM; Kahn CR. 2006. Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c. Diabetes 55(7):2032-41. [PubMed: 16804073]  [MGI Ref ID J:111873]

Bina KG; Cincotta AH. 2000. Dopaminergic agonists normalize elevated hypothalamic neuropeptide Y and corticotropin-releasing hormone, body weight gain, and hyperglycemia in ob/ob mice. Neuroendocrinology 71(1):68-78. [PubMed: 10644901]  [MGI Ref ID J:60273]

Bjorbaek C; Elmquist JK; Frantz JD; Shoelson SE; Flier JS. 1998. Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol Cell 1(4):619-25. [PubMed: 9660946]  [MGI Ref ID J:119803]

Bjursell M; Gerdin AK; Ploj K; Svensson D; Svensson L; Oscarsson J; Snaith M; Tornell J; Bohlooly-Y M. 2006. Melanin-concentrating hormone receptor 1 deficiency increases insulin sensitivity in obese leptin-deficient mice without affecting body weight. Diabetes 55(3):725-33. [PubMed: 16505236]  [MGI Ref ID J:106845]

Bobe G; Barrett KG; Mentor-Marcel RA; Saffiotti U; Young MR; Colburn NH; Albert PS; Bennink MR; Lanza E. 2008. Dietary cooked navy beans and their fractions attenuate colon carcinogenesis in azoxymethane-induced ob/ob mice. Nutr Cancer 60(3):373-81. [PubMed: 18444172]  [MGI Ref ID J:138534]

Bock T; Pakkenberg B; Buschard K. 2003. Increased islet volume but unchanged islet number in ob/ob mice. Diabetes 52(7):1716-22. [PubMed: 12829638]  [MGI Ref ID J:84295]

Bodary PF; Shen Y; Ohman M; Bahrou KL; Vargas FB; Cudney SS; Wickenheiser KJ; Myers MG Jr; Eitzman DT. 2007. Leptin regulates neointima formation after arterial injury through mechanisms independent of blood pressure and the leptin receptor/STAT3 signaling pathways involved in energy balance. Arterioscler Thromb Vasc Biol 27(1):70-6. [PubMed: 17095713]  [MGI Ref ID J:135034]

Borthwick EB; Burchell A; Coughtrie MW. 1995. Differential expression of hepatic oestrogen, phenol and dehydroepiandrosterone sulphotransferases in genetically obese diabetic (ob/ob) male and female mice. J Endocrinol 144(1):31-7. [PubMed: 7891022]  [MGI Ref ID J:22650]

Boston BA; Blaydon KM; Varnerin J; Cone RD. 1997. Independent and additive effects of central POMC and leptin pathways on murine obesity. Science 278(5343):1641-4. [PubMed: 9374468]  [MGI Ref ID J:44399]

Bouchard G; Johnson D; Carver T; Paigen B; Carey MC. 2002. Cholesterol gallstone formation in overweight mice establishes that obesity per se is not linked directly to cholelithiasis risk. J Lipid Res 43(7):1105-13. [PubMed: 12091495]  [MGI Ref ID J:88773]

Boudina S; Sena S; O'Neill BT; Tathireddy P; Young ME; Abel ED. 2005. Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity. Circulation 112(17):2686-95. [PubMed: 16246967]  [MGI Ref ID J:116841]

Bouhidel O; Pons S; Souktani R; Zini R; Berdeaux A; Ghaleh B. 2008. Myocardial ischemic postconditioning against ischemia-reperfusion is impaired in ob/ob mice. Am J Physiol Heart Circ Physiol 295(4):H1580-6. [PubMed: 18689499]  [MGI Ref ID J:141317]

Boundy VA; Cincotta AH. 2000. Hypothalamic adrenergic receptor changes in the metabolic syndrome of genetically obese (ob/ob) mice. Am J Physiol Regul Integr Comp Physiol 279(2):R505-14. [PubMed: 10938239]  [MGI Ref ID J:94672]

Bouret SG; Draper SJ; Simerly RB. 2004. Trophic action of leptin on hypothalamic neurons that regulate feeding. Science 304(5667):108-10. [PubMed: 15064420]  [MGI Ref ID J:90241]

Breslow MJ; An Y; Berkowitz DE. 1997. Beta-3 adrenoceptor (beta-3AR) expression in leptin treated OB/OB mice. Life Sci 61(1):59-64. [PubMed: 9200670]  [MGI Ref ID J:41326]

Breslow MJ; Min-Lee K; Brown DR; Chacko VP; Palmer D; Berkowitz DE. 1999. Effect of leptin deficiency on metabolic rate in ob/ob mice. Am J Physiol 276(3 Pt 1):E443-9. [PubMed: 10070008]  [MGI Ref ID J:53833]

Brix AE; Elgavish A; Nagy TR; Gower BA; Rhead WJ; Wood PA. 2002. Evaluation of liver fatty acid oxidation in the leptin-deficient obese mouse. Mol Genet Metab 75(3):219-26. [PubMed: 11914033]  [MGI Ref ID J:94662]

Brun P; Castagliuolo I; Leo VD; Buda A; Pinzani M; Palu G; Martines D. 2007. Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitis. Am J Physiol Gastrointest Liver Physiol 292(2):G518-25. [PubMed: 17023554]  [MGI Ref ID J:124815]

Bruno RS; Dugan CE; Smyth JA; DiNatale DA; Koo SI. 2008. Green tea extract protects leptin-deficient, spontaneously obese mice from hepatic steatosis and injury. J Nutr 138(2):323-31. [PubMed: 18203899]  [MGI Ref ID J:133407]

Bruton JD; Katz A; Lannergren J; Abbate F; Westerblad H. 2002. Regulation of myoplasmic Ca(2+) in genetically obese (ob/ob) mouse single skeletal muscle fibres. Pflugers Arch 444(6):692-9. [PubMed: 12355168]  [MGI Ref ID J:106205]

Bunger L; Forsting J; McDonald KL; Horvat S; Duncan J; Hochscheid S; Baile CA; Hill WG; Speakman JR. 2003. Long-term divergent selection on fatness in mice indicates a regulation system independent of leptin production and reception. FASEB J 17(1):85-7. [PubMed: 12424222]  [MGI Ref ID J:118012]

Burcelin R; Kamohara S; Li J; Tannenbaum GS; Charron MJ; Friedman JM. 1999. Acute intravenous leptin infusion increases glucose turnover but not skeletal muscle glucose uptake in ob/ob mice. Diabetes 48(6):1264-9. [PubMed: 10342814]  [MGI Ref ID J:55776]

Busso N; So A; Chobaz-Peclat V; Morard C; Martinez-Soria E; Talabot-Ayer D; Gabay C. 2002. Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritis. J Immunol 168(2):875-82. [PubMed: 11777985]  [MGI Ref ID J:73743]

Butler AA; Marks DL; Fan W; Kuhn CM; Bartolome M; Cone RD. 2001. Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat. Nat Neurosci 4(6):605-11. [PubMed: 11369941]  [MGI Ref ID J:69814]

Campfield LA; Smith FJ; Guisez Y; Devos R; Burn P. 1995. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks [see comments] Science 269(5223):546-9. [PubMed: 7624778]  [MGI Ref ID J:29160]

Cani PD; Bibiloni R; Knauf C; Waget A; Neyrinck AM; Delzenne NM; Burcelin R. 2008. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 57(6):1470-81. [PubMed: 18305141]  [MGI Ref ID J:136880]

Cao H; Maeda K; Gorgun CZ; Kim HJ; Park SY; Shulman GI; Kim JK; Hotamisligil GS. 2006. Regulation of metabolic responses by adipocyte/macrophage Fatty Acid-binding proteins in leptin-deficient mice. Diabetes 55(7):1915-22. [PubMed: 16804058]  [MGI Ref ID J:111878]

Cariou B; Capitaine N; Le Marcis V; Vega N; Bereziat V; Kergoat M; Laville M; Girard J; Vidal H; Burnol AF. 2004. Increased adipose tissue expression of Grb14 in several models of insulin resistance. FASEB J 18(9):965-7. [PubMed: 15059968]  [MGI Ref ID J:118114]

Cariou B; van Harmelen K; Duran-Sandoval D; van Dijk TH; Grefhorst A; Abdelkarim M; Caron S; Torpier G; Fruchart JC; Gonzalez FJ; Kuipers F; Staels B. 2006. The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice. J Biol Chem 281(16):11039-49. [PubMed: 16446356]  [MGI Ref ID J:110560]

Carley AN; Severson DL. 2005. Fatty acid metabolism is enhanced in type 2 diabetic hearts. Biochim Biophys Acta 1734(2):112-26. [PubMed: 15904868]  [MGI Ref ID J:99066]

Chakraborty S; Sachdev A; Salton SR; Chakraborty TR. 2008. Stereological analysis of estrogen receptor expression in the hypothalamic arcuate nucleus of ob/ob and agouti mice. Brain Res 1217:86-95. [PubMed: 18502406]  [MGI Ref ID J:138366]

Charlton HM. 1984. Mouse mutants as models in endocrine research. Q J Exp Physiol 69(4):655-76. [PubMed: 6393185]  [MGI Ref ID J:7702]

Chavey C; Lazennec G; Lagarrigue S; Clape C; Iankova I; Teyssier J; Annicotte JS; Schmidt J; Mataki C; Yamamoto H; Sanches R; Guma A; Stich V; Vitkova M; Jardin-Watelet B; Renard E; Strieter R; Tuthill A; Hotamisligil GS; Vidal-Puig A; Zorzano A; Langin D; Fajas L. 2009. CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance. Cell Metab 9(4):339-49. [PubMed: 19356715]  [MGI Ref ID J:148169]

Cheema SK; Clandinin MT. 1996. Diet fat alters expression of genes for enzymes of lipogenesis in lean and obese mice. Biochim Biophys Acta 1299(3):284-8. [PubMed: 8597582]  [MGI Ref ID J:31603]

Chehab FF; Lim ME; Lu R. 1996. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat Genet 12(3):318-20. [PubMed: 8589726]  [MGI Ref ID J:31761]

Chen HC; Ladha Z; Farese RV Jr. 2002. Deficiency of acyl coenzyme a:diacylglycerol acyltransferase 1 increases leptin sensitivity in murine obesity models. Endocrinology 143(8):2893-8. [PubMed: 12130553]  [MGI Ref ID J:78337]

Chen HC; Smith SJ; Ladha Z; Jensen DR; Ferreira LD; Pulawa LK; McGuire JG; Pitas RE; Eckel RH; Farese RV Jr. 2002. Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1. J Clin Invest 109(8):1049-55. [PubMed: 11956242]  [MGI Ref ID J:76091]

Chen HL; Romsos DR. 1996. Dexamethasone rapidly increases hypothalamic neuropeptide Y secretion in adrenalectomized ob/ob mice. Am J Physiol 271(1 Pt 1):E151-8. [PubMed: 8760093]  [MGI Ref ID J:34501]

Chen HL; Romsos DR. 1994. Type II glucocorticoid receptors in the CNS regulate metabolism in ob/ob mice independent of protein synthesis. Am J Physiol 266(3 Pt 1):E427-32. [PubMed: 8166263]  [MGI Ref ID J:17505]

Chen J; Hui ST; Couto FM; Mungrue IN; Davis DB; Attie AD; Lusis AJ; Davis RA; Shalev A. 2008. Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes. FASEB J 22(10):3581-94. [PubMed: 18552236]  [MGI Ref ID J:140264]

Chen J; Saxena G; Mungrue IN; Lusis AJ; Shalev A. 2008. Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis. Diabetes 57(4):938-44. [PubMed: 18171713]  [MGI Ref ID J:135529]

Chen NG; Romsos DR. 1995. Enhanced sensitivity of pancreatic islets from preobese 2-week-old ob/ob mice to neurohormonal stimulation of insulin secretion. Endocrinology 136(2):505-11. [PubMed: 7835283]  [MGI Ref ID J:22634]

Chen NG; Tassava TM; Romsos DR. 1993. Threshold for glucose-stimulated insulin secretion in pancreatic islets of genetically obese (ob/ob) mice is abnormally low. J Nutr 123(9):1567-74. [PubMed: 8360782]  [MGI Ref ID J:14402]

Chen Z; Newberry EP; Norris JY; Xie Y; Luo J; Kennedy SM; Davidson NO. 2008. ApoB100 is required for increased VLDL-triglyceride secretion by microsomal triglyceride transfer protein in ob/ob mice. J Lipid Res 49(9):2013-22. [PubMed: 18519977]  [MGI Ref ID J:139764]

Cheng A; Uetani N; Simoncic PD; Chaubey VP; Lee-Loy A; McGlade CJ; Kennedy BP; Tremblay ML. 2002. Attenuation of Leptin Action and Regulation of Obesity by Protein Tyrosine Phosphatase 1B. Dev Cell 2(4):497-503. [PubMed: 11970899]  [MGI Ref ID J:75969]

Chiu CH; Lin WD; Huang SY; Lee YH. 2004. Effect of a C/EBP gene replacement on mitochondrial biogenesis in fat cells. Genes Dev 18(16):1970-5. [PubMed: 15289464]  [MGI Ref ID J:91840]

Choo HJ; Kim JH; Kwon OB; Lee CS; Mun JY; Han SS; Yoon YS; Yoon G; Choi KM; Ko YG. 2006. Mitochondria are impaired in the adipocytes of type 2 diabetic mice. Diabetologia 49(4):784-91. [PubMed: 16501941]  [MGI Ref ID J:107887]

Christoffersen C; Bollano E; Lindegaard ML; Bartels ED; Goetze JP; Andersen CB; Nielsen LB. 2003. Cardiac lipid accumulation associated with diastolic dysfunction in obese mice. Endocrinology 144(8):3483-90. [PubMed: 12865329]  [MGI Ref ID J:84820]

Chua S Jr; Liu SM; Li Q; Yang L; Thassanapaff VT; Fisher P. 2002. Differential beta cell responses to hyperglycaemia and insulin resistance in two novel congenic strains of diabetes (FVB- Lepr (db)) and obese (DBA- Lep (ob)) mice. Diabetologia 45(7):976-90. [PubMed: 12136396]  [MGI Ref ID J:78850]

Chung WK; Belfi K; Chua M; Wiley J; Mackintosh R; Nicolson M; Boozer CN; Leibel RL. 1998. Heterozygosity for Lep(ob) or Lep(rdb) affects body composition and leptin homeostasis in adult mice. Am J Physiol 274(4 Pt 2):R985-90. [PubMed: 9575960]  [MGI Ref ID J:47168]

Clark EA; Shultz LD; Pollack SB. 1981. Mutations in mice that influence natural killer (NK) cell activity. Immunogenetics 12(5-6):601-13. [PubMed: 6971254]  [MGI Ref ID J:6485]

Claycombe K; King LE; Fraker PJ. 2008. A role for leptin in sustaining lymphopoiesis and myelopoiesis. Proc Natl Acad Sci U S A 105(6):2017-21. [PubMed: 18250302]  [MGI Ref ID J:131806]

Cleary MP; Bergstrom HM; Dodge TL; Getzin SC; Jacobson MK; Phillips FC. 2001. Restoration of fertility in young obese (Lep(ob) Lep(ob)) male mice with low dose recombinant mouse leptin treatment. Int J Obes Relat Metab Disord 25(1):95-7. [PubMed: 11244463]  [MGI Ref ID J:68694]

Cleary MP; Phillips FC; Getzin SC; Jacobson TL; Jacobson MK; Christensen TA; Juneja SC; Grande JP; Maihle NJ. 2003. Genetically obese MMTV-TGF-alpha/Lep(ob)Lep(ob) female mice do not develop mammary tumors. Breast Cancer Res Treat 77(3):205-15. [PubMed: 12602920]  [MGI Ref ID J:81933]

Clee SM; Nadler ST; Attie AD. 2005. Genetic and genomic studies of the BTBR ob/ob mouse model of type 2 diabetes. Am J Ther 12(6):491-8. [PubMed: 16280642]  [MGI Ref ID J:106121]

Clouthier DE; Comerford SA; Hammer RE. 1997. Hepatic fibrosis, glomerulosclerosis, and a lipodystrophy-like syndrome in PEPCK-TGF-beta1 transgenic mice. J Clin Invest 100(11):2697-713. [PubMed: 9389733]  [MGI Ref ID J:135399]

Coleman DL. 1973. Effects of parabiosis of obese with diabetes and normal mice. Diabetologia 9(4):294-8. [PubMed: 4767369]  [MGI Ref ID J:5401]

Coleman DL. 1982. Thermogenesis in diabetes-obesity syndromes in mutant mice. Diabetologia 22(3):205-11. [PubMed: 7075918]  [MGI Ref ID J:6756]

Collin M; Hakansson-Ovesjo ML; Misane I; Ogren SO; Meister B. 2000. Decreased 5-HT transporter mRNA in neurons of the dorsal raphe nucleus and behavioral depression in the obese leptin-deficient ob/ob mouse. Brain Res Mol Brain Res 81(1-2):51-61. [PubMed: 11000478]  [MGI Ref ID J:109340]

Collins S; Daniel KW; Rohlfs EM; Ramkumar V; Taylor IL; Gettys TW. 1994. Impaired expression and functional activity of the beta 3- and beta 1-adrenergic receptors in adipose tissue of congenitally obese (C57BL/6J ob/ob) mice. Mol Endocrinol 8(4):518-27. [PubMed: 7914350]  [MGI Ref ID J:17709]

Collins S; Surwit RS. 1996. Pharmacologic manipulation of ob expression in a dietary model of obesity. J Biol Chem 271(16):9437-40. [PubMed: 8621612]  [MGI Ref ID J:33332]

Cope K; Risby T; Diehl AM. 2000. Increased gastrointestinal ethanol production in obese mice: implications for fatty liver disease pathogenesis. Gastroenterology 119(5):1340-7. [PubMed: 11054393]  [MGI Ref ID J:94789]

De Rosa V; Procaccini C; Cali G; Pirozzi G; Fontana S; Zappacosta S; La Cava A; Matarese G. 2007. A Key Role of Leptin in the Control of Regulatory T Cell Proliferation. Immunity 26(2):241-255. [PubMed: 17307705]  [MGI Ref ID J:118425]

Della-Fera MA; Choi YH; Hartzell DL; Duan J; Hamrick M; Baile CA. 2005. Sensitivity of ob/ob mice to leptin-induced adipose tissue apoptosis. Obes Res 13(9):1540-7. [PubMed: 16222056]  [MGI Ref ID J:114433]

Delporte ML; El Mkadem SA; Quisquater M; Brichard SM. 2004. Leptin treatment markedly increased plasma adiponectin but barely decreased plasma resistin of ob/ob mice. Am J Physiol Endocrinol Metab 287(3):E446-53. [PubMed: 15126241]  [MGI Ref ID J:95406]

Deng J; Hua K; Caveney EJ; Takahashi N; Harp JB. 2006. Protein inhibitor of activated STAT3 inhibits adipogenic gene expression. Biochem Biophys Res Commun 339(3):923-31. [PubMed: 16329991]  [MGI Ref ID J:104136]

Dickie MM; Lane PW. 1957. [Linkage of ob to L.G. XI] Mouse News Lett 17:52.  [MGI Ref ID J:159]

Dixon D; Horton J; Haseman JK; Talley F; Greenwell A; Nettesheim P; Hook GE; Maronpot RR. 1991. Histomorphology and ultrastructure of spontaneous pulmonary neoplasms in strain A mice. Exp Lung Res 17(2):131-55. [PubMed: 1646706]  [MGI Ref ID J:27691]

Dobrzyn A; Dobrzyn P; Lee SH; Miyazaki M; Cohen P; Asilmaz E; Hardie DG; Friedman JM; Ntambi JM. 2005. Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing beta-oxidation in skeletal muscle. Am J Physiol Endocrinol Metab 288(3):E599-607. [PubMed: 15562249]  [MGI Ref ID J:96073]

Dobrzyn P; Dobrzyn A; Miyazaki M; Cohen P; Asilmaz E; Hardie DG; Friedman JM; Ntambi JM. 2004. Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver. Proc Natl Acad Sci U S A 101(17):6409-14. [PubMed: 15096593]  [MGI Ref ID J:89545]

Dokmanovic-Chouinard M; Chung WK; Chevre JC; Watson E; Yonan J; Wiegand B; Bromberg Y; Wakae N; Wright CV; Overton J; Ghosh S; Sathe GM; Ammala CE; Brown KK; Ito R; LeDuc C; Solomon K; Fischer SG; Leibel RL. 2008. Positional cloning of 'Lisch-Like', a candidate modifier of susceptibility to type 2 diabetes in mice. PLoS Genet 4(7):e1000137. [PubMed: 18654634]  [MGI Ref ID J:138216]

Dong F; Zhang X; Yang X; Esberg LB; Yang H; Zhang Z; Culver B; Ren J. 2006. Impaired cardiac contractile function in ventricular myocytes from leptin-deficient ob/ob obese mice. J Endocrinol 188(1):25-36. [PubMed: 16394172]  [MGI Ref ID J:104171]

Drel VR; Mashtalir N; Ilnytska O; Shin J; Li F; Lyzogubov VV; Obrosova IG. 2006. The leptin-deficient (ob/ob) mouse: a new animal model of peripheral neuropathy of type 2 diabetes and obesity. Diabetes 55(12):3335-43. [PubMed: 17130477]  [MGI Ref ID J:121015]

Dubuc PU. 1992. Interactions between insulin and glucocorticoids in the maintenance of genetic obesity. Am J Physiol 263(3 Pt 1):E550-5. [PubMed: 1415535]  [MGI Ref ID J:2939]

Ducy P; Amling M; Takeda S; Priemel M; Schilling AF; Beil FT; Shen J; Vinson C; Rueger JM; Karsenty G. 2000. Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell 100(2):197-207. [PubMed: 10660043]  [MGI Ref ID J:60001]

El-Salhy M. 1998. Neuroendocrine peptides of the gastrointestinal tract of an animal model of human type 2 diabetes mellitus. Acta Diabetol 35(4):194-8. [PubMed: 9934817]  [MGI Ref ID J:55590]

Elefteriou F; Ahn JD; Takeda S; Starbuck M; Yang X; Liu X; Kondo H; Richards WG; Bannon TW; Noda M; Clement K; Vaisse C; Karsenty G. 2005. Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature 434(7032):514-20. [PubMed: 15724149]  [MGI Ref ID J:97566]

Elefteriou F; Takeda S; Ebihara K; Magre J; Patano N; Kim CA; Ogawa Y; Liu X; Ware SM; Craigen WJ; Robert JJ; Vinson C; Nakao K; Capeau J; Karsenty G. 2004. Serum leptin level is a regulator of bone mass. Proc Natl Acad Sci U S A 101(9):3258-63. [PubMed: 14978271]  [MGI Ref ID J:88655]

Elinav E; Pappo O; Sklair-Levy M; Margalit M; Shibolet O; Gomori M; Alper R; Thalenfeld B; Engelhardt D; Rabbani E; Ilan Y. 2006. Adoptive transfer of regulatory NKT lymphocytes ameliorates non-alcoholic steatohepatitis and glucose intolerance in ob/ob mice and is associated with intrahepatic CD8 trapping. J Pathol 209(1):121-8. [PubMed: 16482497]  [MGI Ref ID J:107706]

Elinav E; Pappo O; Sklair-Levy M; Margalit M; Shibolet O; Gomori M; Alper R; Thalenfeld B; Engelhardt D; Rabbani E; Ilan Y. 2006. Amelioration of non-alcoholic steatohepatitis and glucose intolerance in ob/ob mice by oral immune regulation towards liver-extracted proteins is associated with elevated intrahepatic NKT lymphocytes and serum IL-10 levels. J Pathol 208(1):74-81. [PubMed: 16261527]  [MGI Ref ID J:104032]

Emanuelli B; Eberle D; Suzuki R; Kahn CR. 2008. Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance. Proc Natl Acad Sci U S A 105(9):3545-50. [PubMed: 18296638]  [MGI Ref ID J:132675]

Erickson JC; Hollopeter G; Palmiter RD. 1996. Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science 274(5293):1704-7. [PubMed: 8939859]  [MGI Ref ID J:37106]

Erickson JC; Hollopeter G; Palmiter RD. 1997. On raising energy expenditure in ob/ob mice Science 276(5315):1132-3. [PubMed: 9173544]  [MGI Ref ID J:40381]

Evans AA; Hughes S; Smith ME. 1995. Delta-opioid peptide receptors in muscles from obese diabetic and normal mice. Peptides 16(2):361-4. [PubMed: 7784267]  [MGI Ref ID J:24888]

Evans ZP; Ellett JD; Schmidt MG; Schnellmann RG; Chavin KD. 2008. Mitochondrial uncoupling protein-2 mediates steatotic liver injury following ischemia/reperfusion. J Biol Chem 283(13):8573-9. [PubMed: 18086675]  [MGI Ref ID J:135165]

Faggioni R; Fantuzzi G; Gabay C; Moser A; Dinarello CA; Feingold KR ; Grunfeld C. 1999. Leptin deficiency enhances sensitivity to endotoxin-induced lethality. Am J Physiol 276(1 Pt 2):R136-42. [PubMed: 9887187]  [MGI Ref ID J:52477]

Faggioni R; Fuller J; Moser A; Feingold KR; Grunfeld C. 1997. LPS-induced anorexia in leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) mice. Am J Physiol 273(1 Pt 2):R181-6. [PubMed: 9249548]  [MGI Ref ID J:41966]

Faggioni R; Jones-Carson J; Reed DA; Dinarello CA; Feingold KR; Grunfeld C; Fantuzzi G. 2000. Leptin-deficient (ob/ob) mice are protected from T cell-mediated hepatotoxicity: role of tumor necrosis factor alpha and IL-18. Proc Natl Acad Sci U S A 97(5):2367-72. [PubMed: 10681432]  [MGI Ref ID J:60929]

Fan W; Boston BA; Kesterson RA; Hruby VJ; Cone RD. 1997. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome [see comments] Nature 385(6612):165-8. [PubMed: 8990120]  [MGI Ref ID J:37848]

Fauconnier J; Andersson DC; Zhang SJ; Lanner JT; Wibom R; Katz A; Bruton JD; Westerblad H. 2007. Effects of palmitate on Ca(2+) handling in adult control and ob/ob cardiomyocytes: impact of mitochondrial reactive oxygen species. Diabetes 56(4):1136-42. [PubMed: 17229941]  [MGI Ref ID J:122121]

Ferrante AW Jr; Thearle M; Liao T; Leibel RL. 2001. Effects of leptin deficiency and short-term repletion on hepatic gene expression in genetically obese mice. Diabetes 50(10):2268-78. [PubMed: 11574408]  [MGI Ref ID J:71975]

Ferrara CT; Wang P; Neto EC; Stevens RD; Bain JR; Wenner BR; Ilkayeva OR; Keller MP; Blasiole DA; Kendziorski C; Yandell BS; Newgard CB; Attie AD. 2008. Genetic networks of liver metabolism revealed by integration of metabolic and transcriptional profiling. PLoS Genet 4(3):e1000034. [PubMed: 18369453]  [MGI Ref ID J:134375]

Fleig SV; Choi SS; Yang L; Jung Y; Omenetti A; VanDongen HM; Huang J; Sicklick JK; Diehl AM. 2007. Hepatic accumulation of Hedgehog-reactive progenitors increases with severity of fatty liver damage in mice. Lab Invest 87(12):1227-39. [PubMed: 17952094]  [MGI Ref ID J:128723]

Flowers JB; Rabaglia ME; Schueler KL; Flowers MT; Lan H; Keller MP; Ntambi JM; Attie AD. 2007. Loss of stearoyl-CoA desaturase-1 improves insulin sensitivity in lean mice but worsens diabetes in leptin-deficient obese mice. Diabetes 56(5):1228-39. [PubMed: 17369521]  [MGI Ref ID J:122081]

Frank S; Stallmeyer B; Kampfer H; Kolb N; Pfeilschifter J. 2000. Leptin enhances wound re-epithelialization and constitutes a direct function of leptin in skin repair. J Clin Invest 106(4):501-9. [PubMed: 10953025]  [MGI Ref ID J:112351]

Fraser DC; Srivastava J; Woodward CJ; Simpson AE; Jones RB. 1998. A molecular investigation of the obese phenotype in the Aston University strain of ob/ob mice and the Japanese Kuo Kondo mice. Int J Obes Relat Metab Disord 22(2):193-4. [PubMed: 9504329]  [MGI Ref ID J:45748]

Fruhbeck G; Aguado M; Martinez JA. 1997. In vitro lipolytic effect of leptin on mouse adipocytes: evidence for a possible autocrine/paracrine role of leptin. Biochem Biophys Res Commun 240(3):590-4. [PubMed: 9398609]  [MGI Ref ID J:44321]

Fu L; John LM; Adams SH; Yu XX; Tomlinson E; Renz M; Williams PM; Soriano R; Corpuz R; Moffat B; Vandlen R; Simmons L; Foster J; Stephan JP; Tsai SP; Stewart TA. 2004. Fibroblast growth factor 19 increases metabolic rate and reverses dietary and leptin-deficient diabetes. Endocrinology 145(6):2594-603. [PubMed: 14976145]  [MGI Ref ID J:133073]

Fujimoto W; Shiuchi T; Miki T; Minokoshi Y; Takahashi Y; Takeuchi A; Kimura K; Saito M; Iwanaga T; Seino S. 2007. Dmbx1 is essential in agouti-related protein action. Proc Natl Acad Sci U S A 104(39):15514-9. [PubMed: 17873059]  [MGI Ref ID J:125193]

Fulton S; Pissios P; Manchon RP; Stiles L; Frank L; Pothos EN; Maratos-Flier E; Flier JS. 2006. Leptin regulation of the mesoaccumbens dopamine pathway. Neuron 51(6):811-22. [PubMed: 16982425]  [MGI Ref ID J:113646]

Funato H; Tsai AL; Willie JT; Kisanuki Y; Williams SC; Sakurai T; Yanagisawa M. 2009. Enhanced orexin receptor-2 signaling prevents diet-induced obesity and improves leptin sensitivity. Cell Metab 9(1):64-76. [PubMed: 19117547]  [MGI Ref ID J:144346]

Galvez BG ; San Martin N ; Rodriguez C. 2009. TNF-alpha is required for the attraction of mesenchymal precursors to white adipose tissue in Ob/ob mice. PLoS ONE 4(2):e4444. [PubMed: 19214223]  [MGI Ref ID J:146626]

Gao D; Wei C; Chen L; Huang J; Yang S; Diehl AM. 2004. Oxidative DNA damage and DNA repair enzyme expression are inversely related in murine models of fatty liver disease. Am J Physiol Gastrointest Liver Physiol 287(5):G1070-7. [PubMed: 15231485]  [MGI Ref ID J:96152]

Gao H; Bryzgalova G; Hedman E; Khan A; Efendic S; Gustafsson JA; Dahlman-Wright K. 2006. Long-term administration of estradiol decreases expression of hepatic lipogenic genes and improves insulin sensitivity in ob/ob mice: a possible mechanism is through direct regulation of signal transducer and activator of transcription 3. Mol Endocrinol 20(6):1287-99. [PubMed: 16627594]  [MGI Ref ID J:108950]

Garris DR. 2004. Ultrastructural analysis of progressive endometrial hypercytolipidemia induced by obese (ob/ob) and diabetes (db/db) genotype mutations: structural basis of female reproductive tract involution. Tissue Cell 36(1):19-28. [PubMed: 14729450]  [MGI Ref ID J:102445]

Garris DR; Garris BL. 2004. Genomic modulation of diabetes (db/db) and obese (ob/ob) mutation-induced hypercytolipidemia: cytochemical basis of female reproductive tract involution. Cell Tissue Res 316(2):233-41. [PubMed: 15024641]  [MGI Ref ID J:105101]

Gautam D; Gavrilova O; Jeon J; Pack S; Jou W; Cui Y; Li JH; Wess J. 2006. Beneficial metabolic effects of M3 muscarinic acetylcholine receptor deficiency. Cell Metab 4(5):363-75. [PubMed: 17084710]  [MGI Ref ID J:129745]

Gavrilescu LC; Butcher BA; Del Rio L; Taylor GA; Denkers EY. 2004. STAT1 is essential for antimicrobial effector function but dispensable for gamma interferon production during Toxoplasma gondii infection. Infect Immun 72(3):1257-64. [PubMed: 14977926]  [MGI Ref ID J:88582]

Gavrilova O; Barr V; Marcus-Samuels B; Reitman M. 1997. Hyperleptinemia of pregnancy associated with the appearance of a circulating form of the leptin receptor. J Biol Chem 272(48):30546-51. [PubMed: 9374549]  [MGI Ref ID J:44331]

Gavrilova O; Leon LR; Marcus-Samuels B; Mason MM; Castle AL; Refetoff S; Vinson C; Reitman ML. 1999. Torpor in mice is induced by both leptin-dependent and -independent mechanisms. Proc Natl Acad Sci U S A 96(25):14623-8. [PubMed: 10588755]  [MGI Ref ID J:58946]

Getchell TV; Kwong K; Saunders CP; Stromberg AJ; Getchell ML. 2006. Leptin regulates olfactory-mediated behavior in ob/ob mice. Physiol Behav 87(5):848-56. [PubMed: 16549076]  [MGI Ref ID J:112820]

Gettys TW; Watson PM; Seger L; Padgett M; Taylor IL. 1997. Adrenalectomy after weaning restores beta3-adrenergic receptor expression in white adipocytes from C57BL/6J-ob/ob mice. Endocrinology 138(7):2697-704. [PubMed: 9202206]  [MGI Ref ID J:41996]

Gimeno RE; Dembski M; Weng X; Deng N; Shyjan AW; Gimeno CJ; Iris F; Ellis SJ; Woolf EA; Tartaglia LA. 1997. Cloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesis. Diabetes 46(5):900-6. [PubMed: 9133562]  [MGI Ref ID J:40062]

Gloaguen I; Costa P; Demartis A; Lazzaro D; Di Marco A; Graziani R ; Paonessa G ; Chen F ; Rosenblum CI ; Van der Ploeg LH ; Cortese R ; Ciliberto G ; Laufer R. 1997. Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance. Proc Natl Acad Sci U S A 94(12):6456-61. [PubMed: 9177239]  [MGI Ref ID J:40976]

Goren I; Kampfer H; Muller E; Schiefelbein D; Pfeilschifter J; Frank S. 2006. Oncostatin M expression is functionally connected to neutrophils in the early inflammatory phase of skin repair: implications for normal and diabetes-impaired wounds. J Invest Dermatol 126(3):628-37. [PubMed: 16410783]  [MGI Ref ID J:106761]

Goren I; Kampfer H; Podda M; Pfeilschifter J; Frank S. 2003. Leptin and wound inflammation in diabetic ob/ob mice: differential regulation of neutrophil and macrophage influx and a potential role for the scab as a sink for inflammatory cells and mediators. Diabetes 52(11):2821-32. [PubMed: 14578302]  [MGI Ref ID J:86305]

Goren I; Muller E; Pfeilschifter J; Frank S. 2006. Severely impaired insulin signaling in chronic wounds of diabetic ob/ob mice: a potential role of tumor necrosis factor-alpha. Am J Pathol 168(3):765-77. [PubMed: 16507892]  [MGI Ref ID J:106484]

Goudriaan JR; Tacken PJ; Dahlmans VE; Gijbels MJ; van Dijk KW; Havekes LM; Jong MC. 2001. Protection from obesity in mice lacking the VLDL receptor. Arterioscler Thromb Vasc Biol 21(9):1488-93. [PubMed: 11557677]  [MGI Ref ID J:102939]

Gray SL; Nora ED; Grosse J; Manieri M; Stoeger T; Medina-Gomez G; Burling K; Wattler S; Russ A; Yeo GS; Chatterjee VK; O'Rahilly S; Voshol PJ; Cinti S; Vidal-Puig A. 2006. Leptin deficiency unmasks the deleterious effects of impaired peroxisome proliferator-activated receptor gamma function (P465L PPARgamma) in mice. Diabetes 55(10):2669-77. [PubMed: 17003330]  [MGI Ref ID J:116568]

Grefhorst A; van Dijk TH; Hammer A; van der Sluijs FH; Havinga R; Havekes LM; Romijn JA; Groot PH; Reijngoud DJ; Kuipers F. 2005. Differential effects of pharmacological liver X receptor activation on hepatic and peripheral insulin sensitivity in lean and ob/ob mice. Am J Physiol Endocrinol Metab 289(5):E829-38. [PubMed: 15941783]  [MGI Ref ID J:102451]

Gropler MC; Harris TE; Hall AM; Wolins NE; Gross RW; Han X; Chen Z; Finck BN. 2009. Lipin 2 is a liver-enriched phosphatidate phosphohydrolase enzyme that is dynamically regulated by fasting and obesity in mice. J Biol Chem 284(11):6763-72. [PubMed: 19136718]  [MGI Ref ID J:148371]

Gruen ML; Plummer MR; Zhang W; Posey KA; Linton M; Fazio S; Hasty AH. 2005. Persistence of high density lipoprotein particles in obese mice lacking apolipoprotein A-I. J Lipid Res 46(9):2007-14. [PubMed: 15995171]  [MGI Ref ID J:100492]

Gundewar S; Calvert JW; Elrod JW; Lefer DJ. 2007. Cytoprotective effects of N,N,N-trimethylsphingosine during ischemia- reperfusion injury are lost in the setting of obesity and diabetes. Am J Physiol Heart Circ Physiol 293(4):H2462-71. [PubMed: 17630348]  [MGI Ref ID J:126117]

Guo KY; Halo P; Leibel RL; Zhang Y. 2004. Effects of obesity on the relationship of leptin mRNA expression and adipocyte size in anatomically distinct fat depots in mice. Am J Physiol Regul Integr Comp Physiol 287(1):R112-9. [PubMed: 15001430]  [MGI Ref ID J:109323]

Gupte A; Mora S. 2006. Activation of the Cbl insulin signaling pathway in cardiac muscle; dysregulation in obesity and diabetes. Biochem Biophys Res Commun 342(3):751-7. [PubMed: 16494846]  [MGI Ref ID J:106781]

Gustavsson N; Abedi G; Larsson-Nyren G; Lindstrom P. 2006. Timing of Ca2+ response in pancreatic beta-cells is related to mitochondrial mass. Biochem Biophys Res Commun 340(4):1119-24. [PubMed: 16414347]  [MGI Ref ID J:104995]

Hahm S; Fekete C; Mizuno TM; Windsor J; Yan H; Boozer CN; Lee C; Elmquist JK; Lechan RM; Mobbs CV; Salton SR. 2002. VGF is required for obesity induced by diet, gold thioglucose treatment, and agouti and is differentially regulated in pro-opiomelanocortin- and neuropeptide Y-containing arcuate neurons in response to fasting. J Neurosci 22(16):6929-38. [PubMed: 12177191]  [MGI Ref ID J:124244]

Hajri T; Hall AM; Jensen DR; Pietka TA; Drover VA; Tao H; Eckel R; Abumrad NA. 2007. CD36-facilitated fatty acid uptake inhibits leptin production and signaling in adipose tissue. Diabetes 56(7):1872-80. [PubMed: 17440173]  [MGI Ref ID J:126461]

Hakansson-Ovesjo ML; Collin M; Meister B. 2000. Down-regulated STAT3 messenger ribonucleic acid and STAT3 protein in the hypothalamic arcuate nucleus of the obese leptin-deficient (ob/ob) mouse Endocrinology 141(11):3946-55. [PubMed: 11089524]  [MGI Ref ID J:65568]

Halaas JL; Gajiwala KS; Maffei M; Cohen SL; Chait BT; Rabinowitz D; Lallone RL; Burley SK; Friedman JM. 1995. Weight-reducing effects of the plasma protein encoded by the obese gene [see comments] Science 269(5223):543-6. [PubMed: 7624777]  [MGI Ref ID J:29161]

Haller EW; Wittmers LE Jr; Haller IV; Regal RR. 1999. The obese gene is expressed in lean littermates of the genetically obese mouse (C57BL/6J ob/ob). Am J Physiol 276(4 Pt 1):E762-5. [PubMed: 10198314]  [MGI Ref ID J:54704]

Haluzik M; Colombo C; Gavrilova O; Chua S; Wolf N; Chen M; Stannard B; Dietz KR; Le Roith D; Reitman ML. 2004. Genetic background (C57BL/6J versus FVB/N) strongly influences the severity of diabetes and insulin resistance in ob/ob mice. Endocrinology 145(7):3258-64. [PubMed: 15059949]  [MGI Ref ID J:90742]

Hamm ML; Bhat GK; Thompson WE; Mann DR. 2004. Folliculogenesis is impaired and granulosa cell apoptosis is increased in leptin-deficient mice. Biol Reprod 71(1):66-72. [PubMed: 14985253]  [MGI Ref ID J:91001]

Hamrick MW; Pennington C; Newton D; Xie D; Isales C. 2004. Leptin deficiency produces contrasting phenotypes in bones of the limb and spine. Bone 34(3):376-83. [PubMed: 15003785]  [MGI Ref ID J:88559]

Han CY; Subramanian S; Chan CK; Omer M; Chiba T; Wight TN; Chait A. 2007. Adipocyte-derived serum amyloid A3 and hyaluronan play a role in monocyte recruitment and adhesion. Diabetes 56(9):2260-73. [PubMed: 17563062]  [MGI Ref ID J:126587]

Hao M; Head WS; Gunawardana SC; Hasty AH; Piston DW. 2007. Direct effect of cholesterol on insulin secretion: a novel mechanism for pancreatic beta-cell dysfunction. Diabetes 56(9):2328-38. [PubMed: 17575085]  [MGI Ref ID J:126584]

Harris RB. 1999. Parabiosis between db/db and ob/ob or db/+ mice. Endocrinology 140(1):138-45. [PubMed: 9886818]  [MGI Ref ID J:114258]

Harris RB; Hausman DB; Bartness TJ. 2002. Compensation for partial lipectomy in mice with genetic alterations of leptin and its receptor subtypes. Am J Physiol Regul Integr Comp Physiol 283(5):R1094-103. [PubMed: 12376403]  [MGI Ref ID J:113622]

Harris RB; Zhou J; Redmann SM Jr; Smagin GN; Smith SR; Rodgers E; Zachwieja JJ. 1998. A leptin dose-response study in obese (ob/ob) and lean (+/?) mice. Endocrinology 139(1):8-19. [PubMed: 9421392]  [MGI Ref ID J:44829]

Hasegawa T; Ito Y; Wijeweera J; Liu J; Malle E; Farhood A; McCuskey RS; Jaeschke H. 2007. Reduced inflammatory response and increased microcirculatory disturbances during hepatic ischemia-reperfusion injury in steatotic livers of ob/ob mice. Am J Physiol Gastrointest Liver Physiol 292(5):G1385-95. [PubMed: 17307725]  [MGI Ref ID J:122631]

Hasty AH; Shimano H; Osuga Ji; Namatame I; Takahashi A; Yahagi N; Perrey S; Iizuka Y; Tamura Y; Amemiya-Kudo M; Yoshikawa T; Okazaki H; Ohashi K; Harada K; Matsuzaka T; Sone H; Gotoda T; Nagai R; Ishibashi S; Yamada N. 2001. Severe hypercholesterolemia, hypertriglyceridemia, and atherosclerosis in mice lacking both leptin and the low density lipoprotein receptor. J Biol Chem 276(40):37402-8. [PubMed: 11445560]  [MGI Ref ID J:72027]

Hayashi T; Cottam HB; Chan M; Jin G; Tawatao RI; Crain B; Ronacher L; Messer K; Carson DA; Corr M. 2008. Mast cell-dependent anorexia and hypothermia induced by mucosal activation of Toll-like receptor 7. Am J Physiol Regul Integr Comp Physiol 295(1):R123-32. [PubMed: 18480244]  [MGI Ref ID J:148644]

Heffernan M; Summers RJ; Thorburn A; Ogru E; Gianello R; Jiang WJ; Ng FM. 2001. The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice. Endocrinology 142(12):5182-9. [PubMed: 11713213]  [MGI Ref ID J:115409]

Henderson RB; Hobbs JA; Mathies M; Hogg N. 2003. Rapid recruitment of inflammatory monocytes is independent of neutrophil migration. Blood 102(1):328-35. [PubMed: 12623845]  [MGI Ref ID J:115516]

Henkel JS; Beers DR; Siklos L; Appel SH. 2006. The chemokine MCP-1 and the dendritic and myeloid cells it attracts are increased in the mSOD1 mouse model of ALS. Mol Cell Neurosci 31(3):427-37. [PubMed: 16337133]  [MGI Ref ID J:106862]

Herberg L; Coleman DL. 1977. Laboratory animals exhibiting obesity and diabetes syndromes. Metabolism 26(1):59-99. [PubMed: 834144]  [MGI Ref ID J:5759]

Hick RW; Gruver AL; Ventevogel MS; Haynes BF; Sempowski GD. 2006. Leptin selectively augments thymopoiesis in leptin deficiency and lipopolysaccharide-induced thymic atrophy. J Immunol 177(1):169-76. [PubMed: 16785512]  [MGI Ref ID J:134403]

Hinoi E; Gao N; Jung DY; Yadav V; Yoshizawa T; Myers MG Jr; Chua SC Jr; Kim JK; Kaestner KH; Karsenty G. 2008. The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity. J Cell Biol 183(7):1235-42. [PubMed: 19103808]  [MGI Ref ID J:145998]

Hirasawa T; Ohara T; Makino S. 1997. Genetic typing of the mouse ob mutation by PCR and restriction enzyme analysis. Exp Anim 46(1):75-8. [PubMed: 9027475]  [MGI Ref ID J:41265]

Hirosumi J; Tuncman G; Chang L; Gorgun CZ; Uysal KT; Maeda K; Karin M; Hotamisligil GS. 2002. A central role for JNK in obesity and insulin resistance. Nature 420(6913):333-6. [PubMed: 12447443]  [MGI Ref ID J:80452]

Hochgeschwender U; Costa JL; Reed P; Bui S; Brennan MB. 2003. Altered glucose homeostasis in proopiomelanocortin-null mouse mutants lacking central and peripheral melanocortin. Endocrinology 144(12):5194-202. [PubMed: 12970157]  [MGI Ref ID J:87246]

Howard JK; Lord GM; Matarese G; Vendetti S; Ghatei MA; Ritter MA; Lechler RI; Bloom SR. 1999. Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice. J Clin Invest 104(8):1051-9. [PubMed: 10525043]  [MGI Ref ID J:58102]

Hsu A; Aronoff DM; Phipps J; Goel D; Mancuso P. 2007. Leptin improves pulmonary bacterial clearance and survival in ob/ob mice during pneumococcal pneumonia. Clin Exp Immunol 150(2):332-9. [PubMed: 17822444]  [MGI Ref ID J:126350]

Hyogo H; Roy S; Cohen DE. 2003. Restoration of gallstone susceptibility by leptin in C57BL/6J ob/ob mice. J Lipid Res 44(6):1232-40. [PubMed: 12671032]  [MGI Ref ID J:120674]

INGALLS AM; DICKIE MM; SNELL GD. 1950. Obese, a new mutation in the house mouse. J Hered 41(12):317-8. [PubMed: 14824537]  [MGI Ref ID J:13066]

Iizuka K; Miller B; Uyeda K. 2006. Deficiency of carbohydrate-activated transcription factor ChREBP prevents obesity and improves plasma glucose control in leptin-deficient (ob/ob) mice. Am J Physiol Endocrinol Metab 291(2):E358-64. [PubMed: 16705063]  [MGI Ref ID J:111374]

Ikejima S; Sasaki S; Sashinami H; Mori F; Ogawa Y; Nakamura T; Abe Y; Wakabayashi K; Suda T; Nakane A. 2005. Impairment of host resistance to Listeria monocytogenes infection in liver of db/db and ob/ob mice. Diabetes 54(1):182-9. [PubMed: 15616027]  [MGI Ref ID J:105107]

Ioffe E; Moon B; Connolly E; Friedman JM. 1998. Abnormal regulation of the leptin gene in the pathogenesis of obesity. Proc Natl Acad Sci U S A 95(20):11852-7. [PubMed: 9751754]  [MGI Ref ID J:50145]

Ishii M; Fei H; Friedman JM. 2003. Targeted disruption of GPR7, the endogenous receptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity. Proc Natl Acad Sci U S A 100(18):10540-5. [PubMed: 12925742]  [MGI Ref ID J:94820]

Itateyama E; Chiba S; Sakata T; Yoshimatsu H. 2003. Hypothalamic neuronal histamine in genetically obese animals: its implication of leptin action in the brain. Exp Biol Med (Maywood) 228(10):1132-7. [PubMed: 14610251]  [MGI Ref ID J:103056]

Ito A; Suganami T; Yamauchi A; Degawa-Yamauchi M; Tanaka M; Kouyama R; Kobayashi Y; Nitta N; Yasuda K; Hirata Y; Kuziel WA; Takeya M; Kanegasaki S; Kamei Y; Ogawa Y. 2008. Role of CC chemokine receptor 2 in bone marrow cells in the recruitment of macrophages into obese adipose tissue. J Biol Chem 283(51):35715-23. [PubMed: 18977759]  [MGI Ref ID J:143770]

Iwaniec UT; Dube MG; Boghossian S; Song H; Helferich WG; Turner RT; Kalra SP. 2009. Body mass influences cortical bone mass independent of leptin signaling. Bone 44(3):404-12. [PubMed: 19095090]  [MGI Ref ID J:146053]

Jang M; Romsos DR. 1998. Neuropeptide Y and corticotropin-releasing hormone concentrations within specific hypothalamic regions of lean but not ob/ob mice respond to food-deprivation and refeeding. J Nutr 128(12):2520-5. [PubMed: 9868202]  [MGI Ref ID J:52175]

Jatoi A; Cleary MP; Tee CM; Nguyen PL. 2001. Weight gain does not preclude increased ubiquitin conjugation in skeletal muscle: an exploratory study in tumor-bearing mice. Ann Nutr Metab 45(3):116-20. [PubMed: 11423703]  [MGI Ref ID J:70639]

Jetton TL; Liang Y; Cincotta AH. 2001. Systemic treatment with sympatholytic dopamine agonists improves aberrant beta-cell hyperplasia and GLUT2, glucokinase, and insulin immunoreactive levels in ob/ob mice. Metabolism 50(11):1377-84. [PubMed: 11699060]  [MGI Ref ID J:72803]

Jiao P; Chen Q; Shah S; Du J; Tao B; Tzameli I; Yan W; Xu H. 2009. Obesity-related upregulation of monocyte chemotactic factors in adipocytes: involvement of nuclear factor-kappaB and c-Jun NH2-terminal kinase pathways. Diabetes 58(1):104-15. [PubMed: 18835938]  [MGI Ref ID J:147249]

Jo YH; Chen YJ; Chua SC Jr; Talmage DA; Role LW. 2005. Integration of endocannabinoid and leptin signaling in an appetite-related neural circuit. Neuron 48(6):1055-66. [PubMed: 16364907]  [MGI Ref ID J:107590]

Johnson PR; Hirsch J. 1972. Cellularity of adipose depots in six strains of genetically obese mice. J Lipid Res 13(1):2-11. [PubMed: 5059196]  [MGI Ref ID J:5253]

Jurgens HS; Schurmann A; Kluge R; Ortmann S; Klaus S; Joost HG; Tschop MH. 2006. Hyperphagia, lower body temperature, and reduced running wheel activity precede development of morbid obesity in New Zealand obese mice. Physiol Genomics 25(2):234-41. [PubMed: 16614459]  [MGI Ref ID J:144124]

Kaddai V; Jager J; Gonzalez T; Najem-Lendom R; Bonnafous S; Tran A; Le Marchand-Brustel Y; Gual P; Tanti JF; Cormont M. 2009. Involvement of TNF-alpha in abnormal adipocyte and muscle sortilin expression in obese mice and humans. Diabetologia 52(5):932-40. [PubMed: 19219422]  [MGI Ref ID J:148209]

Kamei N; Tobe K; Suzuki R; Ohsugi M; Watanabe T; Kubota N; Ohtsuka-Kowatari N; Kumagai K; Sakamoto K; Kobayashi M; Yamauchi T; Ueki K; Oishi Y; Nishimura S; Manabe I; Hashimoto H; Ohnishi Y; Ogata H; Tokuyama K; Tsunoda M; Ide T; Murakami K; Nagai R; Kadowaki T. 2006. Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance. J Biol Chem 281(36):26602-14. [PubMed: 16809344]  [MGI Ref ID J:116947]

Kampfer H; Pfeilschifter J; Frank S. 2003. Expression and activity of arginase isoenzymes during normal and diabetes-impaired skin repair. J Invest Dermatol 121(6):1544-51. [PubMed: 14675208]  [MGI Ref ID J:120040]

Kampfer H; Schmidt R; Geisslinger G; Pfeilschifter J; Frank S. 2005. Wound inflammation in diabetic ob/ob mice: functional coupling of prostaglandin biosynthesis to cyclooxygenase-1 activity in diabetes-impaired wound healing. Diabetes 54(5):1543-51. [PubMed: 15855344]  [MGI Ref ID J:105193]

Kaneko K; Yamada T; Tsukita S; Takahashi K; Ishigaki Y; Oka Y; Katagiri H. 2009. Obesity alters circadian expressions of molecular clock genes in the brainstem. Brain Res 1263:58-68. [PubMed: 19401184]  [MGI Ref ID J:148090]

Kaplan ML; Oh SS. 1991. Oxygen consumption of muscles from ob/ob and Ay/a strains of obese mice. Int J Obes 15(12):809-12. [PubMed: 1794923]  [MGI Ref ID J:613]

Kaplan ML; Trout JR; Leveille GA. 1976. Adipocyte size distribution in ob/ob mice during preobese and obese phases of development. Proc Soc Exp Biol Med 153(3):476-82. [PubMed: 1013161]  [MGI Ref ID J:5765]

Katiyar SK; Meeran SM. 2007. Obesity increases the risk of UV radiation-induced oxidative stress and activation of MAPK and NF-kappaB signaling. Free Radic Biol Med 42(2):299-310. [PubMed: 17189835]  [MGI Ref ID J:117222]

Ke Y; Qiu J; Ogus S; Shen WJ; Kraemer FB; Chehab FF. 2003. Overexpression of leptin in transgenic mice leads to decreased basal lipolysis, PKA activity, and perilipin levels. Biochem Biophys Res Commun 312(4):1165-70. [PubMed: 14651995]  [MGI Ref ID J:94674]

Kebede M; Favaloro J; Gunton JE; Laybutt DR; Shaw M; Wong N; Fam BC; Aston-Mourney K; Rantzau C; Zulli A; Proietto J; Andrikopoulos S. 2008. Fructose-1,6-bisphosphatase overexpression in pancreatic beta-cells results in reduced insulin secretion: a new mechanism for fat-induced impairment of beta-cell function. Diabetes 57(7):1887-95. [PubMed: 18375435]  [MGI Ref ID J:138232]

Kerouz NJ; Horsch D; Pons S; Kahn CR. 1997. Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse. J Clin Invest 100(12):3164-72. [PubMed: 9399964]  [MGI Ref ID J:44906]

Kesterson RA; Huszar D; Lynch CA; Simerly RB; Cone RD. 1997. Induction of neuropeptide Y gene expression in the dorsal medial hypothalamic nucleus in two models of the agouti obesity syndrome. Mol Endocrinol 11(5):630-7. [PubMed: 9139806]  [MGI Ref ID J:40012]

Khan A; Efendic S. 1995. Evidence that increased glucose cycling in islets of diabetic ob/ob mice is a primary feature of the disease. Am J Physiol 269(4 Pt 1):E623-6. [PubMed: 7485473]  [MGI Ref ID J:29436]

Khan A; Ostenson CG; Berggren PO; Efendic S. 1992. Glucocorticoid increases glucose cycling and inhibits insulin release in pancreatic islets of ob/ob mice. Am J Physiol 263(4 Pt 1):E663-6. [PubMed: 1384356]  [MGI Ref ID J:3045]

Khan A; Zong-Chao L; Efendic S; Landau BR. 1998. Glucose-6-phosphatase activity in the hypothalamus of the ob/ob mouse. Metabolism 47(6):627-9. [PubMed: 9627357]  [MGI Ref ID J:48045]

Khan T; Muise ES; Iyengar P; Wang ZV; Chandalia M; Abate N; Zhang BB; Bonaldo P; Chua S; Scherer PE. 2009. Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI. Mol Cell Biol 29(6):1575-91. [PubMed: 19114551]  [MGI Ref ID J:145762]

Kharitonenkov A; Shiyanova TL; Koester A; Ford AM; Micanovic R; Galbreath EJ; Sandusky GE; Hammond LJ; Moyers JS; Owens RA; Gromada J; Brozinick JT; Hawkins ED; Wroblewski VJ; Li DS; Mehrbod F; Jaskunas SR; Shanafelt AB. 2005. FGF-21 as a novel metabolic regulator. J Clin Invest 115(6):1627-35. [PubMed: 15902306]  [MGI Ref ID J:99202]

Kim JY; van de Wall E; Laplante M; Azzara A; Trujillo ME; Hofmann SM; Schraw T; Durand JL; Li H; Li G; Jelicks LA; Mehler MF; Hui DY; Deshaies Y; Shulman GI; Schwartz GJ; Scherer PE. 2007. Obesity-associated improvements in metabolic profile through expansion of adipose tissue. J Clin Invest 117(9):2621-37. [PubMed: 17717599]  [MGI Ref ID J:127420]

Kim YD; Park KG; Lee YS; Park YY; Kim DK; Nedumaran B; Jang WG; Cho WJ; Ha J; Lee IK; Lee CH; Choi HS. 2008. Metformin inhibits hepatic gluconeogenesis through AMP-activated protein kinase-dependent regulation of the orphan nuclear receptor SHP. Diabetes 57(2):306-14. [PubMed: 17909097]  [MGI Ref ID J:132418]

Kishida Y; Hirao M; Tamai N; Nampei A; Fujimoto T; Nakase T; Shimizu N; Yoshikawa H; Myoui A. 2005. Leptin regulates chondrocyte differentiation and matrix maturation during endochondral ossification. Bone 37(5):607-21. [PubMed: 16039170]  [MGI Ref ID J:102535]

Komori T; Morikawa Y; Tamura S; Doi A; Nanjo K; Senba E. 2005. Subcellular localization of glucose transporter 4 in the hypothalamic arcuate nucleus of ob/ob mice under basal conditions. Brain Res 1049(1):34-42. [PubMed: 15925330]  [MGI Ref ID J:99184]

Kondo T; Kahn CR. 2004. Altered insulin signaling in retinal tissue in diabetic states. J Biol Chem 279(36):37997-8006. [PubMed: 15201286]  [MGI Ref ID J:92558]

Konstantinides S; Schafer K; Koschnick S; Loskutoff DJ. 2001. Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity. J Clin Invest 108(10):1533-40. [PubMed: 11714745]  [MGI Ref ID J:109859]

Krauss S; Zhang CY; Scorrano L; Dalgaard LT; St-Pierre J; Grey ST; Lowell BB. 2003. Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction. J Clin Invest 112(12):1831-42. [PubMed: 14679178]  [MGI Ref ID J:118472]

Kubota N; Terauchi Y; Kubota T; Kumagai H; Itoh S; Satoh H; Yano W; Ogata H; Tokuyama K; Takamoto I; Mineyama T; Ishikawa M; Moroi M; Sugi K; Yamauchi T; Ueki K; Tobe K; Noda T; Nagai R; Kadowaki T. 2006. Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and -independent pathways. J Biol Chem 281(13):8748-55. [PubMed: 16431926]  [MGI Ref ID J:111576]

Kubota N; Yamauchi T; Tobe K; Kadowaki T. 2006. Adiponectin-dependent and -independent pathways in insulin-sensitizing and antidiabetic actions of thiazolidinediones. Diabetes 55 Suppl 2:S32-8.  [MGI Ref ID J:120995]

Kulkarni RN; Wang ZL; Wang RM; Hurley JD; Smith DM; Ghatei MA ; Withers DJ ; Gardiner JV ; Bailey CJ ; Bloom SR. 1997. Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice. J Clin Invest 100(11):2729-36. [PubMed: 9389736]  [MGI Ref ID J:45259]

Kumar KG; Trevaskis JL; Lam DD; Sutton GM; Koza RA; Chouljenko VN; Kousoulas KG; Rogers PM; Kesterson RA; Thearle M; Ferrante AW Jr; Mynatt RL; Burris TP; Dong JZ; Halem HA; Culler MD; Heisler LK; Stephens JM; Butler AA. 2008. Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism. Cell Metab 8(6):468-81. [PubMed: 19041763]  [MGI Ref ID J:144378]

Kumpers P; Gueler F; Rong S; Mengel M; Tossidou I; Peters I; Haller H; Schiffer M. 2007. Leptin is a coactivator of TGF-beta in unilateral ureteral obstructive kidney disease. Am J Physiol Renal Physiol 293(4):F1355-62. [PubMed: 17686962]  [MGI Ref ID J:145120]

Kuo LE; Kitlinska JB; Tilan JU; Li L; Baker SB; Johnson MD; Lee EW; Burnett MS; Fricke ST; Kvetnansky R; Herzog H; Zukowska Z. 2007. Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome. Nat Med 13(7):803-11. [PubMed: 17603492]  [MGI Ref ID J:125084]

Kurrasch DM; Cheung CC; Lee FY; Tran PV; Hata K; Ingraham HA. 2007. The neonatal ventromedial hypothalamus transcriptome reveals novel markers with spatially distinct patterning. J Neurosci 27(50):13624-34. [PubMed: 18077674]  [MGI Ref ID J:130568]

Lalloyer F; Vandewalle B; Percevault F; Torpier G; Kerr-Conte J; Oosterveer M; Paumelle R; Fruchart JC; Kuipers F; Pattou F; Fievet C; Staels B. 2006. Peroxisome Proliferator-Activated Receptor {alpha} Improves Pancreatic Adaptation to Insulin Resistance in Obese Mice and Reduces Lipotoxicity in Human Islets. Diabetes 55(6):1605-13. [PubMed: 16731822]  [MGI Ref ID J:111882]

Lalonde J; Samson P; Poulin S; Deshaies Y; Richard D. 2004. Additive effects of leptin and topiramate in reducing fat deposition in lean and obese ob/ob mice. Physiol Behav 80(4):415-20. [PubMed: 14741225]  [MGI Ref ID J:96339]

Lambert PD; Anderson KD; Sleeman MW; Wong V; Tan J; Hijarunguru A; Corcoran TL; Murray JD; Thabet KE; Yancopoulos GD; Wiegand SJ. 2001. Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity. Proc Natl Acad Sci U S A 98(8):4652-7. [PubMed: 11259650]  [MGI Ref ID J:68826]

Lan H; Rabaglia ME; Stoehr JP; Nadler ST; Schueler KL; Zou F; Yandell BS; Attie AD. 2003. Gene expression profiles of nondiabetic and diabetic obese mice suggest a role of hepatic lipogenic capacity in diabetes susceptibility. Diabetes 52(3):688-700. [PubMed: 12606510]  [MGI Ref ID J:148466]

Lan H; Stoehr JP; Nadler ST; Schueler KL; Yandell BS; Attie AD. 2003. Dimension reduction for mapping mRNA abundance as quantitative traits. Genetics 164(4):1607-14. [PubMed: 12930764]  [MGI Ref ID J:119260]

Lang JE; Williams ES; Mizgerd JP; Shore SA. 2008. Effect of obesity on pulmonary inflammation induced by acute ozone exposure: role of interleukin-6. Am J Physiol Lung Cell Mol Physiol 294(5):L1013-20. [PubMed: 18359888]  [MGI Ref ID J:136626]

Lanner JT; Katz A; Tavi P; Sandstrom ME; Zhang SJ; Wretman C; James S; Fauconnier J; Lannergren J; Bruton JD; Westerblad H. 2006. The role of Ca2+ influx for insulin-mediated glucose uptake in skeletal muscle. Diabetes 55(7):2077-83. [PubMed: 16804078]  [MGI Ref ID J:111855]

Laposky AD; Shelton J; Bass J; Dugovic C; Perrino N; Turek FW. 2006. Altered sleep regulation in leptin-deficient mice. Am J Physiol Regul Integr Comp Physiol 290(4):R894-903. [PubMed: 16293682]  [MGI Ref ID J:115771]

Larcher F; Del Rio M; Serrano F; Segovia JC; Ramirez A; Meana A; Page A; Abad JL; Gonzalez MA; Bueren J; Bernad A; Jorcano JL. 2001. A cutaneous gene therapy approach to human leptin deficiencies: correction of the murine ob/ob phenotype using leptin-targeted keratinocyte grafts. FASEB J 15(9):1529-38. [PubMed: 11427484]  [MGI Ref ID J:115148]

Leckstrom A; Kim ER; Wong D; Mizuno TM. 2009. Xenin, a gastrointestinal peptide, regulates feeding independent of the melanocortin signaling pathway. Diabetes 58(1):87-94. [PubMed: 18984739]  [MGI Ref ID J:149651]

Leclercq IA; Field J; Enriquez A; Farrell GC; Robertson GR. 2000. Constitutive and inducible expression of hepatic CYP2E1 in leptin-deficient ob/ob mice. Biochem Biophys Res Commun 268(2):337-44. [PubMed: 10679205]  [MGI Ref ID J:60404]

Lee FY; Li Y; Yang EK; Yang SQ; Lin HZ; Trush MA; Dannenberg AJ; Diehl AM. 1999. Phenotypic abnormalities in macrophages from leptin-deficient, obese mice. Am J Physiol 276(2 Pt 1):C386-94. [PubMed: 9950766]  [MGI Ref ID J:53122]

Lee JW; Romsos DR. 2001. Leptin-deficient mice commence hypersecreting insulin in response to acetylcholine between 1 and 2 weeks of age. Exp Biol Med (Maywood) 226(10):906-11. [PubMed: 11682696]  [MGI Ref ID J:103303]

Leigh FS; Kaufman LN; Young JB. 1992. Diminished epinephrine excretion in genetically obese (ob/ob) mice and monosodium glutamate-treated rats. Int J Obes Relat Metab Disord 16(8):597-604. [PubMed: 1382044]  [MGI Ref ID J:4033]

Levin N; Nelson C; Gurney A; Vandlen R; de Sauvage F. 1996. Decreased food intake does not completely account for adiposity reduction after ob protein infusion. Proc Natl Acad Sci U S A 93(4):1726-30. [PubMed: 8643697]  [MGI Ref ID J:31728]

Li J; Grigoryev DN; Ye SQ; Thorne L; Schwartz AR; Smith PL; O'Donnell CP; Polotsky VY. 2005. Chronic intermittent hypoxia upregulates genes of lipid biosynthesis in obese mice. J Appl Physiol 99(5):1643-8. [PubMed: 16037401]  [MGI Ref ID J:116867]

Li J; Thorne LN; Punjabi NM; Sun CK; Schwartz AR; Smith PL; Marino RL; Rodriguez A; Hubbard WC; O'Donnell CP; Polotsky VY. 2005. Intermittent hypoxia induces hyperlipidemia in lean mice. Circ Res 97(7):698-706. [PubMed: 16123334]  [MGI Ref ID J:114630]

Li M; Kim DH; Tsenovoy PL; Peterson SJ; Rezzani R; Rodella LF; Aronow WS; Ikehara S; Abraham NG. 2008. Treatment of obese diabetic mice with a heme oxygenase inducer reduces visceral and subcutaneous adiposity, increases adiponectin levels, and improves insulin sensitivity and glucose tolerance. Diabetes 57(6):1526-35. [PubMed: 18375438]  [MGI Ref ID J:136899]

Li N; Young MM; Bailey CJ; Smith ME. 1999. NMDA and AMPA glutamate receptor subtypes in the thoracic spinal cord in lean and obese-diabetic ob/ob mice. Brain Res 849(1-2):34-44. [PubMed: 10592285]  [MGI Ref ID J:59144]

Li SY; Yang X; Ceylan-Isik AF; Du M; Sreejayan N; Ren J. 2006. Cardiac contractile dysfunction in Lep/Lep obesity is accompanied by NADPH oxidase activation, oxidative modification of sarco(endo)plasmic reticulum Ca(2+)-ATPase and myosin heavy chain isozyme switch. Diabetologia 49(6):1434-46. [PubMed: 16612592]  [MGI Ref ID J:111488]

Li X; Grundy SM; Patel SB. 1997. Obesity in db and ob animals leads to impaired hepatic very low density lipoprotein secretion and differential secretion of apolipoprotein B-48 and B-100. J Lipid Res 38(7):1277-88. [PubMed: 9254055]  [MGI Ref ID J:41954]

Li Z; Lin H; Yang S; Diehl AM. 2002. Murine leptin deficiency alters Kupffer cell production of cytokines that regulate the innate immune system. Gastroenterology 123(4):1304-10. [PubMed: 12360490]  [MGI Ref ID J:79334]

Li Z; Oben JA; Yang S; Lin H; Stafford EA; Soloski MJ; Thomas SA; Diehl AM. 2004. Norepinephrine regulates hepatic innate immune system in leptin-deficient mice with nonalcoholic steatohepatitis. Hepatology 40(2):434-41. [PubMed: 15368448]  [MGI Ref ID J:105439]

Liang Y; Cincotta AH. 2001. Increased responsiveness to the hyperglycemic, hyperglucagonemic and hyperinsulinemic effects of circulating norepinephrine in ob/ob mice. Int J Obes Relat Metab Disord 25(5):698-704. [PubMed: 11360153]  [MGI Ref ID J:69134]

Lijnen HR; Christiaens V; Scroyen I; Voros G; Tjwa M; Carmeliet P; Collen D. 2006. Impaired adipose tissue development in mice with inactivation of placental growth factor function. Diabetes 55(10):2698-704. [PubMed: 17003333]  [MGI Ref ID J:116580]

Lim G; Wang S; Zhang Y; Tian Y; Mao J. 2009. Spinal leptin contributes to the pathogenesis of neuropathic pain in rodents. J Clin Invest 119(2):295-304. [PubMed: 19139561]  [MGI Ref ID J:146170]

Lin MH; Romsos DR; Akera T; Leveille GA. 1979. Na+,K+-ATPase enzyme units in skeletal muscle and liver of 14-day-old lean and obese (ob/ob) mice. Proc Soc Exp Biol Med 161(3):235-8. [PubMed: 223169]  [MGI Ref ID J:6182]

Liu Q; Bai C; Chen F; Wang R; MacDonald T; Gu M; Zhang Q; Morsy MA ; Caskey CT. 1998. Uncoupling protein-3: a muscle-specific gene upregulated by leptin in ob/ob mice. Gene 207(1):1-7. [PubMed: 9511737]  [MGI Ref ID J:45946]

Liu Y; Michael MD; Kash S; Bensch WR; Monia BP; Murray SF; Otto KA; Syed SK; Bhanot S; Sloop KW; Sullivan JM; Reifel-Miller A. 2007. Deficiency of adiponectin receptor 2 reduces diet-induced insulin resistance but promotes type 2 diabetes. Endocrinology 148(2):683-92. [PubMed: 17068142]  [MGI Ref ID J:129554]

Liu Y; Millar JS; Cromley DA; Graham M; Crooke R; Billheimer JT; Rader DJ. 2008. Knockdown of acyl-CoA:diacylglycerol acyltransferase 2 with antisense oligonucleotide reduces VLDL TG and ApoB secretion in mice. Biochim Biophys Acta 1781(3):97-104. [PubMed: 18252207]  [MGI Ref ID J:133527]

Liu YL; Emilsson V; Cawthorne MA. 1997. Leptin inhibits glycogen synthesis in the isolated soleus muscle of obese (ob/ob) mice. FEBS Lett 411(2-3):351-5. [PubMed: 9271234]  [MGI Ref ID J:42130]

Lloyd DJ; McCormick J; Helmering J; Kim KW; Wang M; Fordstrom P; Kaufman SA; Lindberg RA; Veniant MM. 2008. Generation and characterization of two novel mouse models exhibiting the phenotypes of the metabolic syndrome: Apob48-/-Lepob/ob mice devoid of ApoE or Ldlr. Am J Physiol Endocrinol Metab 294(3):E496-505. [PubMed: 18160459]  [MGI Ref ID J:133453]

Loffreda S; Yang SQ; Lin HZ; Karp CL; Brengman ML; Wang DJ; Klein AS; Bulkley GB; Bao C; Noble PW; Lane MD; Diehl AM. 1998. Leptin regulates proinflammatory immune responses. FASEB J 12(1):57-65. [PubMed: 9438411]  [MGI Ref ID J:115105]

Loftus TM; Kuhajda FP; Lane MD. 1998. Insulin depletion leads to adipose-specific cell death in obese but not lean mice. Proc Natl Acad Sci U S A 95(24):14168-72. [PubMed: 9826672]  [MGI Ref ID J:51283]

Lopez-Parra M; Titos E; Horrillo R; Ferre N; Gonzalez-Periz A; Martinez-Clemente M; Planaguma A; Masferrer J; Arroyo V; Claria J. 2008. Regulatory effects of arachidonate 5-lipoxygenase on hepatic microsomal TG transfer protein activity and VLDL-triglyceride and apoB secretion in obese mice. J Lipid Res 49(12):2513-23. [PubMed: 18645210]  [MGI Ref ID J:142866]

Lord GM; Matarese G; Howard JK; Baker RJ; Bloom SR; Lechler RI. 1998. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 394(6696):897-901. [PubMed: 9732873]  [MGI Ref ID J:49623]

Lu FL; Johnston RA; Flynt L; Theman TA; Terry RD; Schwartzman IN; Lee A; Shore SA. 2006. Increased pulmonary responses to acute ozone exposure in obese db/db mice. Am J Physiol Lung Cell Mol Physiol 290(5):L856-65. [PubMed: 16373670]  [MGI Ref ID J:115772]

Lumeng CN; Bodzin JL; Saltiel AR. 2007. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 117(1):175-84. [PubMed: 17200717]  [MGI Ref ID J:117438]

Luque RM; Huang ZH; Shah B; Mazzone T; Kineman RD. 2007. Effects of leptin replacement on hypothalamic-pituitary growth hormone axis function and circulating ghrelin levels in ob/ob mice. Am J Physiol Endocrinol Metab 292(3):E891-9. [PubMed: 17122091]  [MGI Ref ID J:118904]

Luque RM; Kineman RD. 2006. Impact of obesity on the growth hormone axis: evidence for a direct inhibitory effect of hyperinsulinemia on pituitary function. Endocrinology 147(6):2754-63. [PubMed: 16513828]  [MGI Ref ID J:129482]

Luque RM; Kineman RD; Tena-Sempere M. 2007. Regulation of hypothalamic expression of KiSS-1 and GPR54 genes by metabolic factors: analyses using mouse models and a cell line. Endocrinology 148(10):4601-11. [PubMed: 17595226]  [MGI Ref ID J:129475]

MacDonald S; Smith ME; Bailey CJ. 1998. Expression of beta-endorphin and its receptors in the spinal cord of obese-diabetic ob/ob mice. Neurosci Lett 248(2):85-8. [PubMed: 9654348]  [MGI Ref ID J:107948]

MacDougald OA; Hwang CS; Fan H; Lane MD. 1995. Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes. Proc Natl Acad Sci U S A 92(20):9034-7. [PubMed: 7568067]  [MGI Ref ID J:29081]

Macia L; Delacre M; Abboud G; Ouk TS; Delanoye A; Verwaerde C; Saule P; Wolowczuk I. 2006. Impairment of dendritic cell functionality and steady-state number in obese mice. J Immunol 177(9):5997-6006. [PubMed: 17056524]  [MGI Ref ID J:140529]

Maeda K; Uysal KT; Makowski L; Gorgun CZ; Atsumi G; Parker RA; Bruning J; Hertzel AV; Bernlohr DA; Hotamisligil GS. 2003. Role of the fatty acid binding protein mal1 in obesity and insulin resistance. Diabetes 52(2):300-7. [PubMed: 12540600]  [MGI Ref ID J:81609]

Maglich JM; Lobe DC; Moore JT. 2009. The nuclear receptor CAR (NR1I3) regulates serum triglyceride levels under conditions of metabolic stress. J Lipid Res 50(3):439-45. [PubMed: 18941143]  [MGI Ref ID J:149091]

Makimura H; Mizuno TM; Roberts J; Silverstein J; Beasley J; Mobbs CV. 2000. Adrenalectomy reverses obese phenotype and restores hypothalamic melanocortin tone in leptin-deficient ob/ob mice Diabetes 49(11):1917-23. [PubMed: 11078460]  [MGI Ref ID J:65482]

Maness LM; Banks WA; Kastin AJ. 2000. Persistence of blood-to-brain transport of leptin in obese leptin-deficient and leptin receptor-deficient mice Brain Res 873(1):165-7. [PubMed: 10915826]  [MGI Ref ID J:63732]

Mari M; Caballero F; Colell A; Morales A; Caballeria J; Fernandez A; Enrich C; Fernandez-Checa JC; Garcia-Ruiz C. 2006. Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis. Cell Metab 4(3):185-98. [PubMed: 16950136]  [MGI Ref ID J:129725]

Mark AL; Shaffer RA; Correia ML; Morgan DA; Sigmund CD; Haynes WG. 1999. Contrasting blood pressure effects of obesity in leptin-deficient ob/ob mice and agouti yellow obese mice. J Hypertens 17(12 Pt 2):1949-53. [PubMed: 10703894]  [MGI Ref ID J:61305]

Marsh DJ; Hollopeter G; Kafer KE; Palmiter RD. 1998. Role of the Y5 neuropeptide Y receptor in feeding and obesity. Nat Med 4(6):718-21. [PubMed: 9623983]  [MGI Ref ID J:87803]

Marti A; Novo FJ; Martinez-Anso E; Zaratiegui M; Aguado M; Martinez JA. 1998. Leptin gene transfer into muscle increases lipolysis and oxygen consumption in white fat tissue in ob/ob mice. Biochem Biophys Res Commun 246(3):859-62. [PubMed: 9618302]  [MGI Ref ID J:47997]

Matarese G; Di Giacomo A; Sanna V; Lord GM; Howard JK; Di Tuoro A; Bloom SR; Lechler RI; Zappacosta S; Fontana S. 2001. Requirement for leptin in the induction and progression of autoimmune encephalomyelitis. J Immunol 166(10):5909-16. [PubMed: 11342605]  [MGI Ref ID J:69350]

Matsunuma A; Horiuchi N. 2007. Leptin attenuates gene expression for renal 25-hydroxyvitamin D3-1alpha-hydroxylase in mice via the long form of the leptin receptor. Arch Biochem Biophys 463(1):118-27. [PubMed: 17400175]  [MGI Ref ID J:123347]

Matsusue K; Gavrilova O; Lambert G; Brewer HB Jr; Ward JM; Inoue Y; LeRoith D; Gonzalez FJ. 2004. Hepatic CCAAT/enhancer binding protein alpha mediates induction of lipogenesis and regulation of glucose homeostasis in leptin-deficient mice. Mol Endocrinol 18(11):2751-64. [PubMed: 15319454]  [MGI Ref ID J:93579]

Matsusue K; Haluzik M; Lambert G; Yim SH; Gavrilova O; Ward JM; Brewer B Jr; Reitman ML; Gonzalez FJ. 2003. Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes. J Clin Invest 111(5):737-47. [PubMed: 12618528]  [MGI Ref ID J:82439]

Matsusue K; Kusakabe T; Noguchi T; Takiguchi S; Suzuki T; Yamano S; Gonzalez FJ. 2008. Hepatic steatosis in leptin-deficient mice is promoted by the PPARgamma target gene Fsp27. Cell Metab 7(4):302-11. [PubMed: 18396136]  [MGI Ref ID J:134335]

Matsuzaka T; Shimano H; Yahagi N; Kato T; Atsumi A; Yamamoto T; Inoue N; Ishikawa M; Okada S; Ishigaki N; Iwasaki H; Iwasaki Y; Karasawa T; Kumadaki S; Matsui T; Sekiya M; Ohashi K; Hasty AH; Nakagawa Y; Takahashi A; Suzuki H; Yatoh S; Sone H; Toyoshima H; Osuga J; Yamada N. 2007. Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance. Nat Med 13(10):1193-202. [PubMed: 17906635]  [MGI Ref ID J:130031]

Mazumder PK; O'Neill BT; Roberts MW; Buchanan J; Yun UJ; Cooksey RC; Boudina S; Abel ED. 2004. Impaired cardiac efficiency and increased fatty acid oxidation in insulin-resistant ob/ob mouse hearts. Diabetes 53(9):2366-74. [PubMed: 15331547]  [MGI Ref ID J:107188]

McPherron AC; Lee SJ. 2002. Suppression of body fat accumulation in myostatin-deficient mice. J Clin Invest 109(5):595-601. [PubMed: 11877467]  [MGI Ref ID J:75344]

McQuaid TS; Saleh MC; Joseph JW; Gyulkhandanyan A; Manning-Fox JE; Maclellan JD; Wheeler MB; Chan CB. 2006. cAMP-mediated signaling normalizes glucose-stimulated insulin secretion in uncoupling protein-2 overexpressing {beta}-cells. J Endocrinol 190(3):669-80. [PubMed: 17003268]  [MGI Ref ID J:112890]

Mcginnis R; Walker J; Margules D; Aird F; Redei E. 1992. Dysregulation of the hypothalamus-pituitary-adrenal axis in male and female, genetically obese (ob/ob) mice J Neuroendocrinol 4(6):765-771.  [MGI Ref ID J:13151]

Medina-Gomez G; Gray SL; Yetukuri L; Shimomura K; Virtue S; Campbell M; Curtis RK; Jimenez-Linan M; Blount M; Yeo GS; Lopez M; Seppanen-Laakso T; Ashcroft FM; Oresic M; Vidal-Puig A. 2007. PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism. PLoS Genet 3(4):e64. [PubMed: 17465682]  [MGI Ref ID J:121534]

Melia HP; Andrews JF; McBennett SM; Porter RK. 1999. Effects of acute leptin administration on the differences in proton leak rate in liver mitochondria from ob/ob mice compared to lean controls. FEBS Lett 458(2):261-4. [PubMed: 10481077]  [MGI Ref ID J:57725]

Memon RA; Grunfeld C; Moser AH; Feingold KR. 1994. Fatty acid synthesis in obese insulin resistant diabetic mice. Horm Metab Res 26(2):85-7. [PubMed: 8200619]  [MGI Ref ID J:17499]

Memon RA; Tecott LH; Nonogaki K; Beigneux A; Moser AH; Grunfeld C; Feingold KR. 2000. Up-regulation of peroxisome proliferator-activated receptors (PPAR-alpha) and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity: troglitazone induces expression of PPAR-gamma-responsive adipose tissue-specific genes in the liver of obese diabetic mice [In Process Citation] Endocrinology 141(11):4021-31. [PubMed: 11089532]  [MGI Ref ID J:65569]

Mercer JG; Moar KM; Hoggard N. 1998. Localization of leptin receptor (Ob-R) messenger ribonucleic acid in the rodent hindbrain. Endocrinology 139(1):29-34. [PubMed: 9421394]  [MGI Ref ID J:44828]

Mercer JG; Moar KM; Rayner DV; Trayhurn P; Hoggard N. 1997. Regulation of leptin receptor and NPY gene expression in hypothalamus of leptin-treated obese (ob/ob) and cold-exposed lean mice. FEBS Lett 402(2-3):185-8. [PubMed: 9037192]  [MGI Ref ID J:38333]

Miao J; Xiao Z; Kanamaluru D; Min G; Yau PM; Veenstra TD; Ellis E; Strom S; Suino-Powell K; Xu HE; Kemper JK. 2009. Bile acid signaling pathways increase stability of Small Heterodimer Partner (SHP) by inhibiting ubiquitin-proteasomal degradation. Genes Dev 23(8):986-96. [PubMed: 19390091]  [MGI Ref ID J:147941]

Minhas KM; Khan SA; Raju SV; Phan AC; Gonzalez DR; Skaf MW; Lee K; Tejani AD; Saliaris AP; Barouch LA; O'Donnell CP; Emala CW; Berkowitz DE; Hare JM. 2005. Leptin repletion restores depressed {beta}-adrenergic contractility in ob/ob mice independently of cardiac hypertrophy. J Physiol 565(Pt 2):463-74. [PubMed: 15760936]  [MGI Ref ID J:112489]

Minn AH; Lan H; Rabaglia ME; Harlan DM; Peculis BA; Attie AD; Shalev A. 2005. Increased insulin translation from an insulin splice-variant overexpressed in diabetes, obesity, and insulin resistance. Mol Endocrinol 19(3):794-803. [PubMed: 15550470]  [MGI Ref ID J:96491]

Mistry AM; Helferich W; Romsos DR. 1994. Elevated neuronal c-Fos-like immunoreactivity and messenger ribonucleic acid (mRNA) in genetically obese (ob/ob) mice. Brain Res 666(1):53-60. [PubMed: 7889367]  [MGI Ref ID J:21819]

Mistry AM; Swick AG; Romsos DR. 1997. Leptin rapidly lowers food intake and elevates metabolic rates in lean and ob/ob mice. J Nutr 127(10):2065-72. [PubMed: 9311966]  [MGI Ref ID J:43304]

Miyawaki K; Yamada Y; Ban N; Ihara Y; Tsukiyama K; Zhou H; Fujimoto S; Oku A; Tsuda K; Toyokuni S; Hiai H; Mizunoya W; Fushiki T; Holst JJ; Makino M; Tashita A; Kobara Y; Tsubamoto Y; Jinnouchi T; Jomori T; Seino Y. 2002. Inhibition of gastric inhibitory polypeptide signaling prevents obesity. Nat Med 8(7):738-42. [PubMed: 12068290]  [MGI Ref ID J:77483]

Miyazaki M; Sampath H; Liu X; Flowers MT; Chu K; Dobrzyn A; Ntambi JM. 2009. Stearoyl-CoA desaturase-1 deficiency attenuates obesity and insulin resistance in leptin-resistant obese mice. Biochem Biophys Res Commun 380(4):818-22. [PubMed: 19338759]  [MGI Ref ID J:147343]

Mizuno TM; Kelley KA; Pasinetti GM; Roberts JL; Mobbs CV. 2003. Transgenic neuronal expression of proopiomelanocortin attenuates hyperphagic response to fasting and reverses metabolic impairments in leptin-deficient obese mice. Diabetes 52(11):2675-83. [PubMed: 14578285]  [MGI Ref ID J:86303]

Mizuno TM; Kleopoulos SP; Bergen HT; Roberts JL; Priest CA; Mobbs CV. 1998. Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting in ob/ob and db/db mice, but is stimulated by leptin. Diabetes 47(2):294-7. [PubMed: 9519731]  [MGI Ref ID J:45531]

Moloney F; Toomey S; Noone E; Nugent A; Allan B; Loscher CE; Roche HM. 2007. Antidiabetic effects of cis-9, trans-11-conjugated linoleic acid may be mediated via anti-inflammatory effects in white adipose tissue. Diabetes 56(3):574-82. [PubMed: 17327424]  [MGI Ref ID J:122028]

Mooney MH; Abdel-Wahab YH; McKillop AM; O'Harte FP; Flatt PR. 2002. Evaluation of glycated glucagon-like peptide-1(7-36)amide in intestinal tissue of normal and diabetic animal models. Biochim Biophys Acta 1569(1-3):75-80. [PubMed: 11853960]  [MGI Ref ID J:75727]

Mori A; Sakurai H; Choo MK; Obi R; Koizumi K; Yoshida C; Shimada Y; Saiki I. 2006. Severe pulmonary metastasis in obese and diabetic mice. Int J Cancer 119(12):2760-7. [PubMed: 16998795]  [MGI Ref ID J:117826]

Mori MA; Araujo RC; Reis FC; Sgai DG; Fonseca RG; Barros CC; Merino VF; Passadore M; Barbosa AM; Ferrari B; Carayon P; Castro CH; Shimuta SI; Luz J; Bascands JL; Schanstra JP; Even PC; Oliveira SM; Bader M; Pesquero JB. 2008. Kinin B1 receptor deficiency leads to leptin hypersensitivity and resistance to obesity. Diabetes 57(6):1491-500. [PubMed: 18332096]  [MGI Ref ID J:136924]

Muurling M; van den Hoek AM; Mensink RP; Pijl H; Romijn JA; Havekes LM; Voshol PJ. 2004. Overexpression of APOC1 in obob mice leads to hepatic steatosis and severe hepatic insulin resistance. J Lipid Res 45(1):9-16. [PubMed: 14523051]  [MGI Ref ID J:87976]

Muzzin P; Eisensmith RC; Copeland KC; Woo SL. 1996. Correction of obesity and diabetes in genetically obese mice by leptin gene therapy. Proc Natl Acad Sci U S A 93(25):14804-8. [PubMed: 8962136]  [MGI Ref ID J:37249]

Nadeau JH. 2003. Modifier genes and protective alleles in humans and mice. Curr Opin Genet Dev 13(3):290-5. [PubMed: 12787792]  [MGI Ref ID J:88012]

Najjar SM; Yang Y; Fernstrom MA; Lee SJ; Deangelis AM; Rjaily GA; Al-Share QY; Dai T; Miller TA; Ratnam S; Ruch RJ; Smith S; Lin SH; Beauchemin N; Oyarce AM. 2005. Insulin acutely decreases hepatic fatty acid synthase activity. Cell Metab 2(1):43-53. [PubMed: 16054098]  [MGI Ref ID J:129840]

Nakagawa Y; Shimano H; Yoshikawa T; Ide T; Tamura M; Furusawa M; Yamamoto T; Inoue N; Matsuzaka T; Takahashi A; Hasty AH; Suzuki H; Sone H; Toyoshima H; Yahagi N; Yamada N. 2006. TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes. Nat Med 12(1):107-113. [PubMed: 16327801]  [MGI Ref ID J:104468]

Naveilhan P; Svensson L; Nystrom S; Ekstrand AJ; Ernfors P. 2002. Attenuation of hypercholesterolemia and hyperglycemia in ob/ob mice by NPY Y2 receptor ablation. Peptides 23(6):1087-91. [PubMed: 12126735]  [MGI Ref ID J:102651]

Nawrocki AR; Rajala MW; Tomas E; Pajvani UB; Saha AK; Trumbauer ME; Pang Z; Chen AS; Ruderman NB; Chen H; Rossetti L; Scherer PE. 2006. Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists. J Biol Chem 281(5):2654-60. [PubMed: 16326714]  [MGI Ref ID J:107486]

Neels JG; Pandey M; Hotamisligil GS; Samad F. 2006. Autoamplification of tumor necrosis factor-alpha: a potential mechanism for the maintenance of elevated tumor necrosis factor-alpha in male but not female obese mice. Am J Pathol 168(2):435-44. [PubMed: 16436658]  [MGI Ref ID J:106303]

Newhall KJ; Cummings DE; Nolan MA; McKnight GS. 2005. Deletion of the RIIbeta-subunit of protein kinase A decreases body weight and increases energy expenditure in the obese, leptin-deficient ob/ob mouse. Mol Endocrinol 19(4):982-91. [PubMed: 15618289]  [MGI Ref ID J:97181]

Nishimura S; Manabe I; Nagasaki M; Seo K; Yamashita H; Hosoya Y; Ohsugi M; Tobe K; Kadowaki T; Nagai R; Sugiura S. 2008. In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue. J Clin Invest 118(2):710-21. [PubMed: 18202748]  [MGI Ref ID J:131401]

Nishina PM; Lowe S; Wang J; Paigen B. 1994. Characterization of plasma lipids in genetically obese mice: the mutants obese, diabetes, fat, tubby, and lethal yellow. Metabolism 43(5):549-53. [PubMed: 8177042]  [MGI Ref ID J:18161]

Nishina PM; Naggert JK; Verstuyft J; Paigen B. 1994. Atherosclerosis in genetically obese mice: the mutants obese, diabetes, fat, tubby, and lethal yellow. Metabolism 43(5):554-8. [PubMed: 8177043]  [MGI Ref ID J:19043]

Nisoli E; Briscini L; Giordano A; Tonello C; Wiesbrock SM; Uysal KT; Cinti S; Carruba MO; Hotamisligil GS. 2000. Tumor necrosis factor alpha mediates apoptosis of brown adipocytes and defective brown adipocyte function in obesity. Proc Natl Acad Sci U S A 97(14):8033-8. [PubMed: 10884431]  [MGI Ref ID J:126631]

O'Donnell CP; Tankersley CG; Polotsky VP; Schwartz AR; Smith PL. 2000. Leptin, obesity, and respiratory function. Respir Physiol 119(2-3):163-70. [PubMed: 10722859]  [MGI Ref ID J:61254]

Oben JA; Roskams T; Yang S; Lin H; Sinelli N; Li Z; Torbenson M; Thomas SA; Diehl AM. 2003. Norepinephrine induces hepatic fibrogenesis in leptin deficient ob/ob mice. Biochem Biophys Res Commun 308(2):284-92. [PubMed: 12901866]  [MGI Ref ID J:85049]

Oh SS; Kaplan ML. 1995. Early treatment of obese (ob/ob) mice with triiodothyronine increases oxidative metabolism in muscle but not in brown adipose tissue or liver. J Nutr 125(1):112-24. [PubMed: 7815168]  [MGI Ref ID J:22377]

Oh SS; Kaplan ML. 1994. Early treatment of obese (ob/ob) mice with triiodothyronine increases oxygen consumption and temperature and decreases body fat content. Proc Soc Exp Biol Med 207(3):260-7. [PubMed: 7800681]  [MGI Ref ID J:22025]

Oh YS; Khil LY; Cho KA; Ryu SJ; Ha MK; Cheon GJ; Lee TS; Yoon JW; Jun HS; Park SC. 2008. A potential role for skeletal muscle caveolin-1 as an insulin sensitivity modulator in ageing-dependent non-obese type 2 diabetes: studies in a new mouse model. Diabetologia 51(6):1025-34. [PubMed: 18408913]  [MGI Ref ID J:137899]

Ohman MK; Shen Y; Obimba CI; Wright AP; Warnock M; Lawrence DA; Eitzman DT. 2008. Visceral adipose tissue inflammation accelerates atherosclerosis in apolipoprotein E-deficient mice. Circulation 117(6):798-805. [PubMed: 18212290]  [MGI Ref ID J:145083]

Oishi K; Ohkura N; Wakabayashi M; Shirai H; Sato K; Matsuda J; Atsumi G; Ishida N. 2006. CLOCK is involved in obesity-induced disordered fibrinolysis in ob/ob mice by regulating PAI-1 gene expression. J Thromb Haemost 4(8):1774-80. [PubMed: 16879220]  [MGI Ref ID J:135847]

Okada T; Nishizawa H; Kurata A; Tamba S; Sonoda M; Yasui A; Kuroda Y; Hibuse T; Maeda N; Kihara S; Hadama T; Tobita K; Akamatsu S; Maeda K; Shimomura I; Funahashi T. 2008. URB is abundantly expressed in adipose tissue and dysregulated in obesity. Biochem Biophys Res Commun 367(2):370-6. [PubMed: 18178152]  [MGI Ref ID J:131031]

Okamoto K; Kakuma T; Fukuchi S; Masaki T; Sakata T; Yoshimatsu H. 2006. Sterol regulatory element binding protein (SREBP)-1 expression in brain is affected by age but not by hormones or metabolic changes. Brain Res 1081(1):19-27. [PubMed: 16554040]  [MGI Ref ID J:108103]

Ordway D; Henao-Tamayo M; Smith E; Shanley C; Harton M; Troudt J; Bai X; Basaraba RJ; Orme IM; Chan ED. 2008. Animal model of Mycobacterium abscessus lung infection. J Leukoc Biol 83(6):1502-11. [PubMed: 18310351]  [MGI Ref ID J:136571]

Ozcan L; Ergin AS; Lu A; Chung J; Sarkar S; Nie D; Myers MG Jr; Ozcan U. 2009. Endoplasmic reticulum stress plays a central role in development of leptin resistance. Cell Metab 9(1):35-51. [PubMed: 19117545]  [MGI Ref ID J:144347]

Padmalayam I; Hasham S; Saxena U; Pillarisetti S. 2009. Lipoic acid synthase (LASY): a novel role in inflammation, mitochondrial function, and insulin resistance. Diabetes 58(3):600-8. [PubMed: 19074983]  [MGI Ref ID J:146930]

Paglialunga S; Fisette A; Yan Y; Deshaies Y; Brouillette JF; Pekna M; Cianflone K. 2008. Acylation-stimulating protein deficiency and altered adipose tissue in alternative complement pathway knockout mice. Am J Physiol Endocrinol Metab 294(3):E521-9. [PubMed: 18160458]  [MGI Ref ID J:133454]

Pajvani UB; Trujillo ME; Combs TP; Iyengar P; Jelicks L; Roth KA; Kitsis RN; Scherer PE. 2005. Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy. Nat Med 11(7):797-803. [PubMed: 15965483]  [MGI Ref ID J:99639]

Park J; Rho HK; Kim KH; Choe SS; Lee YS; Kim JB. 2005. Overexpression of glucose-6-phosphate dehydrogenase is associated with lipid dysregulation and insulin resistance in obesity. Mol Cell Biol 25(12):5146-57. [PubMed: 15923630]  [MGI Ref ID J:99224]

Park KW; Waki H; Villanueva CJ; Monticelli LA; Hong C; Kang S; Macdougald OA; Goldrath AW; Tontonoz P. 2008. Inhibitor of DNA Binding 2 Is a Small Molecule-Inducible Modulator of Peroxisome Proliferator-Activated Receptor-{gamma} Expression and Adipocyte Differentiation. Mol Endocrinol 22(9):2038-48. [PubMed: 18562627]  [MGI Ref ID J:138276]

Parker JC; Lavery KS; Irwin N; Green BD; Greer B; Harriott P; O'Harte FP; Gault VA; Flatt PR. 2006. Effects of sub-chronic exposure to naturally occurring N-terminally truncated metabolites of glucose-dependent insulinotrophic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), GIP(3-42) and GLP-1(9-36)amide, on insulin secretion and glucose homeostasis in ob/ob mice. J Endocrinol 191(1):93-100. [PubMed: 17065392]  [MGI Ref ID J:114957]

Parker JC; VanVolkenburg MA; Nardone NA; Hargrove DM; Andrews KM. 1997. Modulation of insulin secretion and glycemia by selective inhibition of cyclic AMP phosphodiesterase III. Biochem Biophys Res Commun 236(3):665-9. [PubMed: 9245710]  [MGI Ref ID J:42064]

Parton LE; Ye CP; Coppari R; Enriori PJ; Choi B; Zhang CY; Xu C; Vianna CR; Balthasar N; Lee CE; Elmquist JK; Cowley MA; Lowell BB. 2007. Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity. Nature 449(7159):228-32. [PubMed: 17728716]  [MGI Ref ID J:125165]

Patsouris D; Li PP; Thapar D; Chapman J; Olefsky JM; Neels JG. 2008. Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell Metab 8(4):301-9. [PubMed: 18840360]  [MGI Ref ID J:143426]

Pelleymounter MA; Cullen MJ; Baker MB; Hecht R; Winters D; Boone T; Collins F. 1995. Effects of the obese gene product on body weight regulation in ob/ob mice [see comments] Science 269(5223):540-3. [PubMed: 7624776]  [MGI Ref ID J:29162]

Perera HK; Caldwell ME; Hayes-Patterson D; Teng L; Peshavaria M; Jetton TL; Labosky PA. 2006. Expression and shifting subcellular localization of the transcription factor, Foxd3, in embryonic and adult pancreas. Gene Expr Patterns 6(8):971-7. [PubMed: 16750430]  [MGI Ref ID J:112316]

Petrolonis AJ; Yang Q; Tummino PJ; Fish SM; Prack AE; Jain S; Parsons TF; Li P; Dales NA; Ge L; Langston SP; Schuller AG; An WF; Tartaglia LA; Chen H; Hong SB. 2004. Enzymatic characterization of the pancreatic islet-specific glucose-6-phosphatase-related protein (IGRP). J Biol Chem 279(14):13976-83. [PubMed: 14722102]  [MGI Ref ID J:124542]

Phan LK; Chung WK; Leibel RL. 2006. The mahoganoid mutation (Mgrn1md) improves insulin sensitivity in mice with mutations in the melanocortin signaling pathway independently of effects on adiposity. Am J Physiol Endocrinol Metab 291(3):E611-20. [PubMed: 16638826]  [MGI Ref ID J:112364]

Phan LK; Lin F; LeDuc CA; Chung WK; Leibel RL. 2002. The mouse mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein. J Clin Invest 110(10):1449-59. [PubMed: 12438443]  [MGI Ref ID J:80182]

Pinto S; Roseberry AG; Liu H; Diano S; Shanabrough M; Cai X; Friedman JM; Horvath TL. 2004. Rapid rewiring of arcuate nucleus feeding circuits by leptin. Science 304(5667):110-5. [PubMed: 15064421]  [MGI Ref ID J:90242]

Plaisancie P; Ducroc R; El Homsi M; Tsocas A; Guilmeau S; Zoghbi S; Thibaudeau O; Bado A. 2006. Luminal leptin activates mucin-secreting goblet cells in the large bowel. Am J Physiol Gastrointest Liver Physiol 290(4):G805-12. [PubMed: 16455789]  [MGI Ref ID J:109110]

Polotsky VY; Li J; Punjabi NM; Rubin AE; Smith PL; Schwartz AR; O'Donnell CP. 2003. Intermittent hypoxia increases insulin resistance in genetically obese mice. J Physiol 552(Pt 1):253-64. [PubMed: 12878760]  [MGI Ref ID J:105382]

Polotsky VY; Wilson JA; Smaldone MC; Haines AS; Hurn PD; Tankersley CG; Smith PL; Schwartz AR; O'Donnell CP. 2001. Female gender exacerbates respiratory depression in leptin-deficient obesity. Am J Respir Crit Care Med 164(8 Pt 1):1470-5. [PubMed: 11704598]  [MGI Ref ID J:94673]

Poy MN; Hausser J; Trajkovski M; Braun M; Collins S; Rorsman P; Zavolan M; Stoffel M. 2009. miR-375 maintains normal pancreatic alpha- and beta-cell mass. Proc Natl Acad Sci U S A 106(14):5813-8. [PubMed: 19289822]  [MGI Ref ID J:147572]

Pralong FP; Gonzales C; Voirol MJ; Palmiter RD; Brunner HR; Gaillard RC; Seydoux J; Pedrazzini T. 2002. The neuropeptide Y Y1 receptor regulates leptin-mediated control of energy homeostasis and reproductive functions. FASEB J 16(7):712-4. [PubMed: 11978737]  [MGI Ref ID J:120451]

Purushotham A; Wendel AA; Liu LF; Belury MA. 2007. Maintenance of adiponectin attenuates insulin resistance induced by dietary conjugated linoleic acid in mice. J Lipid Res 48(2):444-52. [PubMed: 17050906]  [MGI Ref ID J:118228]

Qi L; Saberi M; Zmuda E; Wang Y; Altarejos J; Zhang X; Dentin R; Hedrick S; Bandyopadhyay G; Hai T; Olefsky J; Montminy M. 2009. Adipocyte CREB promotes insulin resistance in obesity. Cell Metab 9(3):277-86. [PubMed: 19254572]  [MGI Ref ID J:147096]

Qi Y; Nie Z; Lee YS; Singhal NS; Scherer PE; Lazar MA; Ahima RS. 2006. Loss of resistin improves glucose homeostasis in leptin deficiency. Diabetes 55(11):3083-90. [PubMed: 17065346]  [MGI Ref ID J:116550]

Qiu J; Ogus S; Mounzih K; Ewart-Toland A; Chehab FF. 2001. Leptin-deficient mice backcrossed to the BALB/cJ genetic background have reduced adiposity, enhanced fertility, normal body temperature, and severe diabetes. Endocrinology 142(8):3421-5. [PubMed: 11459786]  [MGI Ref ID J:94784]

Rafael J; Herling AW. 2000. Leptin effect in ob/ob mice under thermoneutral conditions depends not necessarily on central satiation. Am J Physiol Regul Integr Comp Physiol 278(3):R790-5. [PubMed: 10712302]  [MGI Ref ID J:60885]

Rajala MW; Qi Y; Patel HR; Takahashi N; Banerjee R; Pajvani UB; Sinha MK; Gingerich RL; Scherer PE; Ahima RS. 2004. Regulation of resistin expression and circulating levels in obesity, diabetes, and fasting. Diabetes 53(7):1671-9. [PubMed: 15220189]  [MGI Ref ID J:107202]

Raju SV; Zheng M; Schuleri KH; Phan AC; Bedja D; Saraiva RM; Yiginer O; Vandegaer K; Gabrielson KL; O'donnell CP; Berkowitz DE; Barouch LA; Hare JM. 2006. Activation of the cardiac ciliary neurotrophic factor receptor reverses left ventricular hypertrophy in leptin-deficient and leptin-resistant obesity. Proc Natl Acad Sci U S A 103(11):4222-7. [PubMed: 16537512]  [MGI Ref ID J:107586]

Rashid A; Wu TC; Huang CC; Chen CH; Lin HZ; Yang SQ; Lee FY; Diehl AM. 1999. Mitochondrial proteins that regulate apoptosis and necrosis are induced in mouse fatty liver. Hepatology 29(4):1131-8. [PubMed: 10094957]  [MGI Ref ID J:55979]

Rentsch J; Levens N; Chiesi M. 1995. Recombinant ob-gene product reduces food intake in fasted mice. Biochem Biophys Res Commun 214(1):131-6. [PubMed: 7669033]  [MGI Ref ID J:28578]

Rogove AD; Lu W; Tsirka SE. 2002. Microglial activation and recruitment, but not proliferation, suffice to mediate neurodegeneration. Cell Death Differ 9(8):801-6. [PubMed: 12107823]  [MGI Ref ID J:115569]

Ropelle ER; Pauli JR; Fernandes MF; Rocco SA; Marin RM; Morari J; Souza KK; Dias MM; Gomes-Marcondes MC; Gontijo JA; Franchini KG; Velloso LA; Saad MJ; Carvalheira JB. 2008. A central role for neuronal AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) in high-protein diet-induced weight loss. Diabetes 57(3):594-605. [PubMed: 18057094]  [MGI Ref ID J:132294]

Roseberry AG; Liu H; Jackson AC; Cai X; Friedman JM. 2004. Neuropeptide Y-mediated inhibition of proopiomelanocortin neurons in the arcuate nucleus shows enhanced desensitization in ob/ob mice. Neuron 41(5):711-22. [PubMed: 15003171]  [MGI Ref ID J:88691]

Roseberry AG; Painter T; Mark GP; Williams JT. 2007. Decreased vesicular somatodendritic dopamine stores in leptin-deficient mice. J Neurosci 27(26):7021-7. [PubMed: 17596451]  [MGI Ref ID J:122961]

Ruddle NH; Conta BS; Leinwand L; Kozak C; Ruddle F; Besmer P; Baltimore D. 1978. Assignment of the receptor for ecotropic murine leukemia virus to mouse chromosome 5. J Exp Med 148(2):451-65. [PubMed: 212501]  [MGI Ref ID J:6045]

Ruschke K; Ebelt H; Kloting N; Boettger T; Raum K; Bluher M; Braun T. 2009. Defective peripheral nerve development is linked to abnormal architecture and metabolic activity of adipose tissue in Nscl-2 mutant mice. PLoS ONE 4(5):e5516. [PubMed: 19436734]  [MGI Ref ID J:148882]

Sabeva NS; Rouse EJ; Graf GA. 2007. Defects in the leptin axis reduce abundance of the ABCG5-ABCG8 sterol transporter in liver. J Biol Chem 282(31):22397-405. [PubMed: 17561514]  [MGI Ref ID J:124801]

Sahai A; Malladi P; Pan X; Paul R; Melin-Aldana H; Green RM; Whitington PF. 2004. Obese and diabetic db/db mice develop marked liver fibrosis in a model of nonalcoholic steatohepatitis: role of short-form leptin receptors and osteopontin. Am J Physiol Gastrointest Liver Physiol 287(5):G1035-43. [PubMed: 15256362]  [MGI Ref ID J:96143]

Sainsbury A; Schwarzer C; Couzens M; Herzog H. 2002. Y2 receptor deletion attenuates the type 2 diabetic syndrome of ob/ob mice. Diabetes 51(12):3420-7. [PubMed: 12453895]  [MGI Ref ID J:107169]

Sainsbury A; Schwarzer C; Couzens M; Jenkins A; Oakes SR; Ormandy CJ; Herzog H. 2002. Y4 receptor knockout rescues fertility in ob/ob mice. Genes Dev 16(9):1077-88. [PubMed: 12000791]  [MGI Ref ID J:76479]

Sakkou M; Wiedmer P; Anlag K; Hamm A; Seuntjens E; Ettwiller L; Tschop MH; Treier M. 2007. A role for brain-specific homeobox factor bsx in the control of hyperphagia and locomotory behavior. Cell Metab 5(6):450-63. [PubMed: 17550780]  [MGI Ref ID J:122746]

Saleh J; Blevins JE; Havel PJ; Barrett JA; Gietzen DW; Cianflone K. 2001. Acylation stimulating protein (ASP) acute effects on postprandial lipemia and food intake in rodents. Int J Obes Relat Metab Disord 25(5):705-13. [PubMed: 11360154]  [MGI Ref ID J:69140]

Saleh MC; Wheeler MB; Chan CB. 2006. Endogenous islet uncoupling protein-2 expression and loss of glucose homeostasis in ob/ob mice. J Endocrinol 190(3):659-67. [PubMed: 17003267]  [MGI Ref ID J:112889]

Samad F; Hester KD; Yang G; Hannun YA; Bielawski J. 2006. Altered adipose and plasma sphingolipid metabolism in obesity: a potential mechanism for cardiovascular and metabolic risk. Diabetes 55(9):2579-87. [PubMed: 16936207]  [MGI Ref ID J:116590]

Samad F; Pandey M; Loskutoff DJ. 1998. Tissue factor gene expression in the adipose tissues of obese mice. Proc Natl Acad Sci U S A 95(13):7591-6. [PubMed: 9636194]  [MGI Ref ID J:48272]

Samad F; Uysal KT; Wiesbrock SM; Pandey M; Hotamisligil GS; Loskutoff DJ. 1999. Tumor necrosis factor alpha is a key component in the obesity-linked elevation of plasminogen activator inhibitor 1. Proc Natl Acad Sci U S A 96(12):6902-7. [PubMed: 10359811]  [MGI Ref ID J:55722]

Saraiva RM; Minhas KM; Zheng M; Pitz E; Treuer A; Gonzalez D; Schuleri KH; Vandegaer KM; Barouch LA; Hare JM. 2007. Reduced neuronal nitric oxide synthase expression contributes to cardiac oxidative stress and nitroso-redox imbalance in ob/ob mice. Nitric Oxide 16(3):331-8. [PubMed: 17307368]  [MGI Ref ID J:124484]

Sato S; Hanada R; Kimura A; Abe T; Matsumoto T; Iwasaki M; Inose H; Ida T; Mieda M; Takeuchi Y; Fukumoto S; Fujita T; Kato S; Kangawa K; Kojima M; Shinomiya K; Takeda S. 2007. Central control of bone remodeling by neuromedin U. Nat Med 13(10):1234-40. [PubMed: 17873881]  [MGI Ref ID J:129930]

Schafer K; Fujisawa K; Konstantinides S; Loskutoff DJ. 2001. Disruption of the plasminogen activator inhibitor 1 gene reduces the adiposity and improves the metabolic profile of genetically obese and diabetic ob/ob mice. FASEB J 15(10):1840-2. [PubMed: 11481248]  [MGI Ref ID J:70695]

Schneider JG; Finck BN; Ren J; Standley KN; Takagi M; Maclean KH; Bernal-Mizrachi C; Muslin AJ; Kastan MB; Semenkovich CF. 2006. ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome. Cell Metab 4(5):377-89. [PubMed: 17084711]  [MGI Ref ID J:129761]

Schwartz MW; Baskin DG; Bukowski TR; Kuijper JL; Foster D; Lasser G; Prunkard DE; Porte D Jr; Woods SC; Seeley RJ; Weigle DS. 1996. Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 45(4):531-5. [PubMed: 8603777]  [MGI Ref ID J:32265]

Schwartz MW; Erickson JC; Baskin DG; Palmiter RD. 1998. Effect of fasting and leptin deficiency on hypothalamic neuropeptide Y gene transcription in vivo revealed by expression of a lacZ reporter gene. Endocrinology 139(5):2629-35. [PubMed: 9564880]  [MGI Ref ID J:114273]

Scrocchi LA; Hill ME; Saleh J; Perkins B; Drucker DJ. 2000. Elimination of glucagon-like peptide 1R signaling does not modify weight gain and islet adaptation in mice with combined disruption of leptin and GLP-1 action. Diabetes 49(9):1552-60. [PubMed: 10969840]  [MGI Ref ID J:64159]

Segal-Lieberman G; Bradley RL; Kokkotou E; Carlson M; Trombly DJ; Wang X; Bates S; Myers MG Jr; Flier JS; Maratos-Flier E. 2003. Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotype. Proc Natl Acad Sci U S A 100(17):10085-90. [PubMed: 12897241]  [MGI Ref ID J:85176]

Sekiya M; Osuga J; Okazaki H; Yahagi N; Harada K; Shen WJ; Tamura Y; Tomita S; Iizuka Y; Ohashi K; Okazaki M; Sata M; Nagai R; Fujita T; Shimano H; Kraemer FB; Yamada N; Ishibashi S. 2004. Absence of hormone-sensitive lipase inhibits obesity and adipogenesis in Lep ob/ob mice. J Biol Chem 279(15):15084-90. [PubMed: 14752112]  [MGI Ref ID J:89519]

Sekiya M; Osuga J; Yahagi N; Okazaki H; Tamura Y; Igarashi M; Takase S; Harada K; Okazaki S; Iizuka Y; Ohashi K; Yagyu H; Okazaki M; Gotoda T; Nagai R; Kadowaki T; Shimano H; Yamada N; Ishibashi S. 2008. Hormone-sensitive lipase is involved in hepatic cholesteryl ester hydrolysis. J Lipid Res 49(8):1829-38. [PubMed: 18480494]  [MGI Ref ID J:138444]

Sekiya M; Yahagi N; Matsuzaka T; Najima Y; Nakakuki M; Nagai R; Ishibashi S; Osuga J; Yamada N; Shimano H. 2003. Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression. Hepatology 38(6):1529-39. [PubMed: 14647064]  [MGI Ref ID J:106018]

Sell H; Berger JP; Samson P; Castriota G; Lalonde J; Deshaies Y; Richard D. 2004. Peroxisome proliferator-activated receptor gamma agonism increases the capacity for sympathetically mediated thermogenesis in lean and ob/ob mice. Endocrinology 145(8):3925-34. [PubMed: 15131020]  [MGI Ref ID J:105624]

Sennello JA; Fayad R; Morris AM; Eckel RH; Asilmaz E; Montez J; Friedman JM; Dinarello CA; Fantuzzi G. 2005. Regulation of T cell-mediated hepatic inflammation by adiponectin and leptin. Endocrinology 146(5):2157-64. [PubMed: 15677756]  [MGI Ref ID J:109480]

Sennello JA; Fayad R; Pini M; Gove ME; Ponemone V; Cabay RJ; Siegmund B; Dinarello CA; Fantuzzi G. 2008. Interleukin-18, together with interleukin-12, induces severe acute pancreatitis in obese but not in nonobese leptin-deficient mice. Proc Natl Acad Sci U S A 105(23):8085-90. [PubMed: 18515422]  [MGI Ref ID J:137046]

Senokuchi T; Liang CP; Seimon TA; Han S; Matsumoto M; Banks AS; Paik JH; DePinho RA; Accili D; Tabas I; Tall AR. 2008. Forkhead transcription factors (FoxOs) promote apoptosis of insulin-resistant macrophages during cholesterol-induced endoplasmic reticulum stress. Diabetes 57(11):2967-76. [PubMed: 18728232]  [MGI Ref ID J:142468]

Sha H; He Y; Chen H; Wang C; Zenno A; Shi H; Yang X; Zhang X; Qi L. 2009. The IRE1alpha-XBP1 pathway of the unfolded protein response is required for adipogenesis. Cell Metab 9(6):556-64. [PubMed: 19490910]  [MGI Ref ID J:149823]

Shaw RJ; Lamia KA; Vasquez D; Koo SH; Bardeesy N; Depinho RA; Montminy M; Cantley LC. 2005. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 310(5754):1642-6. [PubMed: 16308421]  [MGI Ref ID J:104202]

Shen L; Tso P; Woods SC; Clegg DJ; Barber KL; Carey K; Liu M. 2008. Brain apolipoprotein E: an important regulator of food intake in rats. Diabetes 57(8):2092-8. [PubMed: 18559657]  [MGI Ref ID J:141777]

Shi H; Kokoeva MV; Inouye K; Tzameli I; Yin H; Flier JS. 2006. TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest 116(11):3015-25. [PubMed: 17053832]  [MGI Ref ID J:114608]

Shi H; Tzameli I; Bjorbaek C; Flier JS. 2004. Suppressor of cytokine signaling 3 is a physiological regulator of adipocyte insulin signaling. J Biol Chem 279(33):34733-40. [PubMed: 15181014]  [MGI Ref ID J:121205]

Shigemura N; Ohta R; Kusakabe Y; Miura H; Hino A; Koyano K; Nakashima K; Ninomiya Y. 2004. Leptin modulates behavioral responses to sweet substances by influencing peripheral taste structures. Endocrinology 145(2):839-47. [PubMed: 14592964]  [MGI Ref ID J:96388]

Shimomura I; Bashmakov Y; Horton JD. 1999. Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus. J Biol Chem 274(42):30028-32. [PubMed: 10514488]  [MGI Ref ID J:58018]

Shimomura I; Matsuda M; Hammer RE; Bashmakov Y; Brown MS; Goldstein JL. 2000. Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. Mol Cell 6(1):77-86. [PubMed: 10949029]  [MGI Ref ID J:63895]

Shutter JR; Graham M; Kinsey AC; Scully S; Luthy R; Stark KL. 1997. Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice. Genes Dev 11(5):593-602. [PubMed: 9119224]  [MGI Ref ID J:39234]

Siegmund B; Sennello JA; Lehr HA; Batra A; Fedke I; Zeitz M; Fantuzzi G. 2004. Development of intestinal inflammation in double IL-10- and leptin-deficient mice. J Leukoc Biol 76(4):782-6. [PubMed: 15240754]  [MGI Ref ID J:93117]

Silver DL; Jiang XC; Tall AR. 1999. Increased high density lipoprotein (HDL), defective hepatic catabolism of ApoA-I and ApoA-II, and decreased ApoA-I mRNA in ob/ob mice. Possible role of leptin in stimulation of HDL turnover. J Biol Chem 274(7):4140-6. [PubMed: 9933608]  [MGI Ref ID J:115228]

Silver DL; Wang N; Tall AR. 2000. Defective HDL particle uptake in ob/ob hepatocytes causes decreased recycling, degradation, and selective lipid uptake. J Clin Invest 105(2):151-9. [PubMed: 10642593]  [MGI Ref ID J:124840]

Singhal NS; Patel RT; Qi Y; Lee YS; Ahima RS. 2008. Loss of resistin ameliorates hyperlipidemia and hepatic steatosis in leptin-deficient mice. Am J Physiol Endocrinol Metab 295(2):E331-8. [PubMed: 18505833]  [MGI Ref ID J:139905]

Sjoholm A; Arkhammar P; Berggren PO; Andersson A. 2001. Polyamines in pancreatic islets of obese-hyperglycemic (ob/ob) mice of different ages. Am J Physiol Cell Physiol 280(2):C317-23. [PubMed: 11208527]  [MGI Ref ID J:68066]

Solinas G; Naugler W; Galimi F; Lee MS; Karin M. 2006. Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates. Proc Natl Acad Sci U S A 103(44):16454-9. [PubMed: 17050683]  [MGI Ref ID J:116088]

Sorensen H; Brand CL; Neschen S; Holst JJ; Fosgerau K; Nishimura E; Shulman GI. 2006. Immunoneutralization of endogenous glucagon reduces hepatic glucose output and improves long-term glycemic control in diabetic ob/ob mice. Diabetes 55(10):2843-8. [PubMed: 17003351]  [MGI Ref ID J:116540]

Soukas A; Cohen P; Socci ND; Friedman JM. 2000. Leptin-specific patterns of gene expression in white adipose tissue. Genes Dev 14(8):963-80. [PubMed: 10783168]  [MGI Ref ID J:61962]

Steinberg GR; Michell BJ; van Denderen BJ; Watt MJ; Carey AL; Fam BC; Andrikopoulos S; Proietto J; Gorgun CZ; Carling D; Hotamisligil GS; Febbraio MA; Kay TW; Kemp BE. 2006. Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling. Cell Metab 4(6):465-74. [PubMed: 17141630]  [MGI Ref ID J:129774]

Stratigopoulos G; Padilla SL; Leduc CA; Watson E; Hattersley AT; McCarthy MI; Zeltser LM; Chung WK; Leibel RL. 2008. Regulation of Fto/Ftm gene expression in mice and humans. Am J Physiol Regul Integr Comp Physiol 294(4):R1185-96. [PubMed: 18256137]  [MGI Ref ID J:133509]

Suganami E; Takagi H; Ohashi H; Suzuma K; Suzuma I; Oh H; Watanabe D; Ojima T; Suganami T; Fujio Y; Nakao K; Ogawa Y; Yoshimura N. 2004. Leptin stimulates ischemia-induced retinal neovascularization: possible role of vascular endothelial growth factor expressed in retinal endothelial cells. Diabetes 53(9):2443-8. [PubMed: 15331557]  [MGI Ref ID J:92072]

Sugita H; Fujimoto M; Yasukawa T; Shimizu N; Sugita M; Yasuhara S; Martyn JA; Kaneki M. 2005. Inducible nitric-oxide synthase and NO donor induce insulin receptor substrate-1 degradation in skeletal muscle cells. J Biol Chem 280(14):14203-11. [PubMed: 15805118]  [MGI Ref ID J:98746]

Sun Y; Asnicar M; Saha PK; Chan L; Smith RG. 2006. Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice. Cell Metab 3(5):379-86. [PubMed: 16679295]  [MGI Ref ID J:129645]

Suto J. 2007. The A y allele at the agouti locus enhances sensitivity to endotoxin-induced lethality in mice. J Vet Med Sci 69(9):931-7. [PubMed: 17917378]  [MGI Ref ID J:141486]

Swoap SJ. 2001. Altered leptin signaling is sufficient, but not required, for hypotension associated with caloric restriction. Am J Physiol Heart Circ Physiol 281(6):H2473-9. [PubMed: 11709414]  [MGI Ref ID J:108672]

Swoap SJ; Weinshenker D. 2008. Norepinephrine controls both torpor initiation and emergence via distinct mechanisms in the mouse. PLoS ONE 3(12):e4038. [PubMed: 19107190]  [MGI Ref ID J:144352]

Szczypka MS; Rainey MA; Palmiter RD. 2000. Dopamine is required for hyperphagia in Lep(ob/ob) mice. Nat Genet 25(1):102-4. [PubMed: 10802666]  [MGI Ref ID J:61883]

Takahashi N; Waelput W; Guisez Y. 1999. Leptin is an endogenous protective protein against the toxicity exerted by tumor necrosis factor. J Exp Med 189(1):207-12. [PubMed: 9874578]  [MGI Ref ID J:52060]

Taleb S; Herbin O; Ait-Oufella H; Verreth W; Gourdy P; Barateau V; Merval R; Esposito B; Clement K; Holvoet P; Tedgui A; Mallat Z. 2007. Defective leptin/leptin receptor signaling improves regulatory T cell immune response and protects mice from atherosclerosis. Arterioscler Thromb Vasc Biol 27(12):2691-8. [PubMed: 17690315]  [MGI Ref ID J:147531]

Tanaka T; Yamamoto J; Iwasaki S; Asaba H; Hamura H; Ikeda Y; Watanabe M; Magoori K; Ioka RX; Tachibana K; Watanabe Y; Uchiyama Y; Sumi K; Iguchi H; Ito S; Doi T; Hamakubo T; Naito M; Auwerx J; Yanagisawa M; Kodama T; Sakai J. 2003. Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome. Proc Natl Acad Sci U S A 100(26):15924-9. [PubMed: 14676330]  [MGI Ref ID J:114135]

Tanii M; Yonemitsu Y; Fujii T; Shikada Y; Kohno R; Onimaru M; Okano S; Inoue M; Hasegawa M; Onohara T; Maehara Y; Sueishi K. 2006. Diabetic microangiopathy in ischemic limb is a disease of disturbance of the platelet-derived growth factor-BB/protein kinase C axis but not of impaired expression of angiogenic factors. Circ Res 98(1):55-62. [PubMed: 16306442]  [MGI Ref ID J:118090]

Tarzi RM; Cook HT; Jackson I; Pusey CD; Lord GM. 2004. Leptin-deficient mice are protected from accelerated nephrotoxic nephritis. Am J Pathol 164(2):385-90. [PubMed: 14742244]  [MGI Ref ID J:88373]

Taylor IL; Garcia R. 1985. Effects of pancreatic polypeptide, caerulein, and bombesin on satiety in obese mice. Am J Physiol 248(3 Pt 1):G277-80. [PubMed: 3976886]  [MGI Ref ID J:7767]

Thrybom T; Rooth P; Lindstrom P. 2001. Effect of serotonin reuptake inhibitor on syndrome development in obese hyperglycemic mice (Umea ob/ob). Metabolism 50(2):144-50. [PubMed: 11229420]  [MGI Ref ID J:68407]

Thurlby PL; Trayhurn P. 1979. The role of thermoregulatory thermogenesis in the development of obesity in genetically-obese (ob/ob) mice pair-fed with lean siblings. Br J Nutr 42(3):377-85. [PubMed: 508700]  [MGI Ref ID J:6236]

Toh SY; Gong J; Du G; Li JZ; Yang S; Ye J; Yao H; Zhang Y; Xue B; Li Q; Yang H; Wen Z; Li P. 2008. Up-regulation of mitochondrial activity and acquirement of brown adipose tissue-like property in the white adipose tissue of fsp27 deficient mice. PLoS ONE 3(8):e2890. [PubMed: 18682832]  [MGI Ref ID J:140122]

Trayhurn P; James WP. 1978. Thermoregulation and non-shivering thermogenesis in the genetically obese (ob/ob) mouse. Pflugers Arch 373(2):189-93. [PubMed: 565045]  [MGI Ref ID J:5958]

Trayhurn P; Thomas ME; Duncan JS; Rayner DV. 1995. Effects of fasting and refeeding on ob gene expression in white adipose tissue of lean and obese (oblob) mice. FEBS Lett 368(3):488-90. [PubMed: 7635205]  [MGI Ref ID J:27455]

Trayhurn P; Thurlby PL; James WP. 1977. Thermogenic defect in pre-obese ob/ob mice. Nature 266(5597):60-2. [PubMed: 840297]  [MGI Ref ID J:12010]

Trevaskis JL; Butler AA. 2005. Double leptin and melanocortin-4 receptor gene mutations have an additive effect on fat mass and are associated with reduced effects of leptin on weight loss and food intake. Endocrinology 146(10):4257-65. [PubMed: 15994342]  [MGI Ref ID J:101555]

Trevaskis JL; Meyer EA; Galgani JE; Butler AA. 2008. Counterintuitive effects of double-heterozygous null melanocortin-4 receptor and leptin genes on diet-induced obesity and insulin resistance in C57BL/6J mice. Endocrinology 149(1):174-84. [PubMed: 17932216]  [MGI Ref ID J:141477]

Trotter-Mayo RN; Roberts MR. 2008. Leptin acts in the periphery to protect thymocytes from glucocorticoid-mediated apoptosis in the absence of weight loss. Endocrinology 149(10):5209-18. [PubMed: 18583419]  [MGI Ref ID J:145495]

Turner SM; Roy S; Sul HS; Neese RA; Murphy EJ; Samandi W; Roohk DJ; Hellerstein MK. 2007. Dissociation between adipose tissue fluxes and lipogenic gene expression in ob/ob mice. Am J Physiol Endocrinol Metab 292(4):E1101-9. [PubMed: 17164440]  [MGI Ref ID J:120374]

Udagawa J; Hashimoto R; Hioki K; Otani H. 2006. The role of leptin in the development of the cortical neuron in mouse embryos. Brain Res 1120(1):74-82. [PubMed: 17020752]  [MGI Ref ID J:116065]

Udagawa J; Hashimoto R; Suzuki H; Hatta T; Sotomaru Y; Hioki K; Kagohashi Y; Nomura T; Minami Y; Otani H. 2006. The role of leptin in the development of the cerebral cortex in mouse embryos. Endocrinology 147(2):647-58. [PubMed: 16282354]  [MGI Ref ID J:105139]

Udagawa J; Nimura M; Kagohashi Y; Otani H. 2006. Leptin deficiency causes pycnotic change in fetal cingulate cortical cells. Congenit Anom (Kyoto) 46(1):16-20. [PubMed: 16643594]  [MGI Ref ID J:111445]

Ueno N; Oh-ishi S; Segawa M; Nishida M; Fukuwatari Y; Kizaki T; Ookawara T; Ohno H. 1998. Effect of age on brown adipose tissue activity in the obese (ob/ob) mouse. Mech Ageing Dev 100(1):67-76. [PubMed: 9509396]  [MGI Ref ID J:46004]

Ukropec J; Anunciado RV; Ravussin Y; Kozak LP. 2006. Leptin is required for uncoupling protein-1-independent thermogenesis during cold stress. Endocrinology 147(5):2468-80. [PubMed: 16469807]  [MGI Ref ID J:129662]

Um SH; Frigerio F; Watanabe M; Picard F; Joaquin M; Sticker M; Fumagalli S; Allegrini PR; Kozma SC; Auwerx J; Thomas G. 2004. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature 431(7005):200-5. [PubMed: 15306821]  [MGI Ref ID J:92663]

Uysal KT; Scheja L; Wiesbrock SM; Bonner-Weir S; Hotamisligil GS. 2000. Improved glucose and lipid metabolism in genetically obese mice lacking aP2. Endocrinology 141(9):3388-96. [PubMed: 10965911]  [MGI Ref ID J:108811]

Uysal KT; Wiesbrock SM; Hotamisligil GS. 1998. Functional analysis of tumor necrosis factor (TNF) receptors in TNF-alpha-mediated insulin resistance in genetic obesity. Endocrinology 139(12):4832-8. [PubMed: 9832419]  [MGI Ref ID J:110666]

Vachharajani V; Russell JM; Scott KL; Conrad S; Stokes KY; Tallam L; Hall J; Granger DN. 2005. Obesity exacerbates sepsis-induced inflammation and microvascular dysfunction in mouse brain. Microcirculation 12(2):183-94. [PubMed: 15828130]  [MGI Ref ID J:114228]

Valerio A; Cardile A; Cozzi V; Bracale R; Tedesco L; Pisconti A; Palomba L; Cantoni O; Clementi E; Moncada S; Carruba MO; Nisoli E. 2006. TNF-alpha downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents. J Clin Invest 116(10):2791-8. [PubMed: 16981010]  [MGI Ref ID J:115008]

Vergnes L; Beigneux AP; Davis R; Watkins SM; Young SG; Reue K. 2006. Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity. J Lipid Res 47(4):745-54. [PubMed: 16436371]  [MGI Ref ID J:108332]

Vicent D; Maratos-Flier E; Kahn CR. 2000. The branch point enzyme of the mevalonate pathway for protein prenylation is overexpressed in the ob/ob mouse and induced by adipogenesis. Mol Cell Biol 20(6):2158-66. [PubMed: 10688662]  [MGI Ref ID J:60599]

Vicent D; Piper M; Gammeltoft S; Maratos-Flier E; Kahn CR. 1998. Alterations in skeletal muscle gene expression of ob/ob mice by mRNA differential display [published erratum appears in Diabetes 1998 Dec;47(12):1978] Diabetes 47(9):1451-8. [PubMed: 9726234]  [MGI Ref ID J:49410]

Vidal-Puig A; Jimenez-Linan M; Lowell BB; Hamann A; Hu E; Spiegelman B; Flier JS; Moller DE. 1996. Regulation of PPAR gamma gene expression by nutrition and obesity in rodents. J Clin Invest 97(11):2553-61. [PubMed: 8647948]  [MGI Ref ID J:33358]

Voros G; Maquoi E; Demeulemeester D; Clerx N; Collen D; Lijnen HR. 2005. Modulation of angiogenesis during adipose tissue development in murine models of obesity. Endocrinology 146(10):4545-54. [PubMed: 16020476]  [MGI Ref ID J:129817]

Voros G; Sandy JD; Collen D; Lijnen HR. 2006. Expression of aggrecan(ases) during murine preadipocyte differentiation and adipose tissue development. Biochim Biophys Acta 1760(12):1837-44. [PubMed: 17011710]  [MGI Ref ID J:117021]

Wade JM; Juneja P; MacKay AW; Graham J; Havel PJ; Tecott LH; Goulding EH. 2008. Synergistic impairment of glucose homeostasis in ob/ob mice lacking functional serotonin 2C receptors. Endocrinology 149(3):955-61. [PubMed: 18039786]  [MGI Ref ID J:135963]

Wang F; Tong Q. 2008. Transcription factor PU.1 is expressed in white adipose and inhibits adipocyte differentiation. Am J Physiol Cell Physiol 295(1):C213-20. [PubMed: 18463231]  [MGI Ref ID J:138523]

Wang Y; Botolin D; Xu J; Christian B; Mitchell E; Jayaprakasam B; Nair MG; Peters JM; Busik JV; Olson LK; Jump DB. 2006. Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity. J Lipid Res 47(9):2028-41. [PubMed: 16790840]  [MGI Ref ID J:114583]

Watanabe M; Houten SM; Wang L; Moschetta A; Mangelsdorf DJ; Heyman RA; Moore DD; Auwerx J. 2004. Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. J Clin Invest 113(10):1408-18. [PubMed: 15146238]  [MGI Ref ID J:120199]

Watanabe T; Kubota N; Ohsugi M; Kubota T; Takamoto I; Iwabu M; Awazawa M; Katsuyama H; Hasegawa C; Tokuyama K; Moroi M; Sugi K; Yamauchi T; Noda T; Nagai R; Terauchi Y; Tobe K; Ueki K; Kadowaki T. 2009. Rimonabant ameliorates insulin resistance via both adiponectin-dependent and adiponectin-independent pathways. J Biol Chem 284(3):1803-12. [PubMed: 19008231]  [MGI Ref ID J:145886]

Watson E; Hahm S; Mizuno TM; Windsor J; Montgomery C; Scherer PE; Mobbs CV; Salton SR. 2005. VGF ablation blocks the development of hyperinsulinemia and hyperglycemia in several mouse models of obesity. Endocrinology 146(12):5151-63. [PubMed: 16141392]  [MGI Ref ID J:129798]

Weigle DS; Bukowski TR; Foster DC; Holderman S; Kramer JM; Lasser G; Lofton-Day CE; Prunkard DE; Raymond C; Kuijper JL. 1995. Recombinant ob protein reduces feeding and body weight in the ob/ob mouse. J Clin Invest 96(4):2065-70. [PubMed: 7560100]  [MGI Ref ID J:29075]

Weinstock PH; Levak-Frank S; Hudgins LC; Radner H; Friedman JM ; Zechner R ; Breslow JL. 1997. Lipoprotein lipase controls fatty acid entry into adipose tissue, but fat mass is preserved by endogenous synthesis in mice deficient in adipose tissue lipoprotein lipase. Proc Natl Acad Sci U S A 94(19):10261-6. [PubMed: 9294198]  [MGI Ref ID J:42930]

Wendel AA; Purushotham A; Liu LF; Belury MA. 2008. Conjugated linoleic acid fails to worsen insulin resistance but induces hepatic steatosis in the presence of leptin in ob/ob mice. J Lipid Res 49(1):98-106. [PubMed: 17906221]  [MGI Ref ID J:130036]

Wieland CW; Florquin S; Chan ED; Leemans JC; Weijer S; Verbon A; Fantuzzi G; van der Poll T. 2005. Pulmonary Mycobacterium tuberculosis infection in leptin-deficient ob/ob mice. Int Immunol 17(11):1399-408. [PubMed: 16141243]  [MGI Ref ID J:102314]

Wolfrum C; Asilmaz E; Luca E; Friedman JM; Stoffel M. 2004. Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes. Nature 432(7020):1027-32. [PubMed: 15616563]  [MGI Ref ID J:95662]

Wolfrum C; Howell JJ; Ndungo E; Stoffel M. 2008. Foxa2 activity increases plasma high density lipoprotein levels by regulating apolipoprotein M. J Biol Chem 283(24):16940-9. [PubMed: 18381283]  [MGI Ref ID J:138581]

Wong GW; Krawczyk SA; Kitidis-Mitrokostas C; Ge G; Spooner E; Hug C; Gimeno R; Lodish HF. 2009. Identification and characterization of CTRP9, a novel secreted glycoprotein, from adipose tissue that reduces serum glucose in mice and forms heterotrimers with adiponectin. FASEB J 23(1):241-58. [PubMed: 18787108]  [MGI Ref ID J:146036]

Wright WS; Longo KA; Dolinsky VW; Gerin I; Kang S; Bennett CN; Chiang SH; Prestwich TC; Gress C; Burant CF; Susulic VS; MacDougald OA. 2007. Wnt10b inhibits obesity in ob/ob and agouti mice. Diabetes 56(2):295-303. [PubMed: 17259372]  [MGI Ref ID J:121960]

Wu Y; Kim JY; Zhou S; Smas CM. 2008. Differential screening identifies transcripts with depot-dependent expression in white adipose tissues. BMC Genomics 9:397. [PubMed: 18721461]  [MGI Ref ID J:141023]

Xia Z; Sniderman AD; Cianflone K. 2002. Acylation-stimulating Protein (ASP) Deficiency Induces Obesity Resistance and Increased Energy Expenditure in ob/ob Mice. J Biol Chem 277(48):45874-9. [PubMed: 12244109]  [MGI Ref ID J:80546]

Xin XG; Huang XF. 1998. Down-regulated NPY receptor subtype-5 mRNA expression in genetically obese mouse brain. Neuroreport 9(4):737-41. [PubMed: 9559948]  [MGI Ref ID J:46895]

Xu H; Barnes GT; Yang Q; Tan G; Yang D; Chou CJ; Sole J; Nichols A; Ross JS; Tartaglia LA; Chen H. 2003. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112(12):1821-30. [PubMed: 14679177]  [MGI Ref ID J:86952]

Xu J; Wang P; Li Y; Li G; Kaczmarek LK; Wu Y; Koni PA; Flavell RA; Desir GV. 2004. The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity. Proc Natl Acad Sci U S A 101(9):3112-7. [PubMed: 14981264]  [MGI Ref ID J:88651]

Xu N; Nilsson-Ehle P; Hurtig M; Ahren B. 2004. Both leptin and leptin-receptor are essential for apolipoprotein M expression in vivo. Biochem Biophys Res Commun 321(4):916-21. [PubMed: 15358114]  [MGI Ref ID J:91738]

Yahagi N; Shimano H; Hasty AH; Matsuzaka T; Ide T; Yoshikawa T; Amemiya-Kudo M; Tomita S; Okazaki H; Tamura Y; Iizuka Y; Ohashi K; Osuga J; Harada K; Gotoda T; Nagai R; Ishibashi S; Yamada N. 2002. Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice. J Biol Chem 277(22):19353-7. [PubMed: 11923308]  [MGI Ref ID J:76758]

Yahagi N; Shimano H; Matsuzaka T; Najima Y; Sekiya M; Nakagawa Y; Ide T; Tomita S; Okazaki H; Tamura Y; Iizuka Y; Ohashi K; Gotoda T; Nagai R; Kimura S; Ishibashi S; Osuga J; Yamada N. 2003. p53 Activation in adipocytes of obese mice. J Biol Chem 278(28):25395-400. [PubMed: 12734185]  [MGI Ref ID J:120652]

Yahagi N; Shimano H; Matsuzaka T; Sekiya M; Najima Y; Okazaki S; Okazaki H; Tamura Y; Iizuka Y; Inoue N; Nakagawa Y; Takeuchi Y; Ohashi K; Harada K; Gotoda T; Nagai R; Kadowaki T; Ishibashi S; Osuga J; Yamada N. 2004. p53 involvement in the pathogenesis of fatty liver disease. J Biol Chem 279(20):20571-5. [PubMed: 14985341]  [MGI Ref ID J:124263]

Yamauchi T; Kamon J; Waki H; Imai Y; Shimozawa N; Hioki K; Uchida S; Ito Y; Takakuwa K; Matsui J; Takata M; Eto K; Terauchi Y; Komeda K; Tsunoda M; Murakami K; Ohnishi Y; Naitoh T; Yamamura K; Ueyama Y; Froguel P; Kimura S; Nagai R; Kadowaki T. 2003. Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis. J Biol Chem 278(4):2461-8. [PubMed: 12431986]  [MGI Ref ID J:81727]

Yang M; Zhang Y; Pan J; Sun J; Liu J; Libby P; Sukhova GK; Doria A; Katunuma N; Peroni OD; Guerre-Millo M; Kahn BB; Clement K; Shi GP. 2007. Cathepsin L activity controls adipogenesis and glucose tolerance. Nat Cell Biol 9(8):970-7. [PubMed: 17643114]  [MGI Ref ID J:129484]

Yang S; Lin HZ; Hwang J; Chacko VP; Diehl AM. 2001. Hepatic hyperplasia in noncirrhotic fatty livers: is obesity-related hepatic steatosis a premalignant condition? Cancer Res 61(13):5016-23. [PubMed: 11431335]  [MGI Ref ID J:70169]

Yang SQ; Lin HZ; Mandal AK; Huang J; Diehl AM. 2001. Disrupted signaling and inhibited regeneration in obese mice with fatty livers: implications for nonalcoholic fatty liver disease pathophysiology. Hepatology 34(4 Pt 1):694-706. [PubMed: 11584365]  [MGI Ref ID J:106504]

Ye J; Gao Z; Yin J; He Q. 2007. Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. Am J Physiol Endocrinol Metab 293(4):E1118-28. [PubMed: 17666485]  [MGI Ref ID J:125547]

Yeh JK; Evans JF; Niu QT; Aloia JF. 2006. A possible role for melanocortin peptides in longitudinal growth. J Endocrinol 191(3):677-86. [PubMed: 17170224]  [MGI Ref ID J:116680]

Yin J; Gao Z; He Q; Zhou D; Guo Z; Ye J. 2009. Role of hypoxia in obesity-induced disorders of glucose and lipid metabolism in adipose tissue. Am J Physiol Endocrinol Metab 296(2):E333-42. [PubMed: 19066318]  [MGI Ref ID J:146063]

Yoon JC; Puigserver P; Chen G; Donovan J; Wu Z; Rhee J; Adelmant G; Stafford J; Kahn CR; Granner DK; Newgard CB; Spiegelman BM. 2001. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature 413(6852):131-8. [PubMed: 11557972]  [MGI Ref ID J:120036]

Yoon JW; Leiter EH; Coleman DL; Kim MK; Pak CY; McArthur RG; Roncari DA. 1988. Genetic control of organ-reactive autoantibody production in mice by obesity (ob) diabetes (db) genes. Diabetes 37(9):1287-93. [PubMed: 3044893]  [MGI Ref ID J:109940]

Yuan M; Konstantopoulos N; Lee J; Hansen L; Li ZW; Karin M; Shoelson SE. 2001. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science 293(5535):1673-7. [PubMed: 11533494]  [MGI Ref ID J:94827]

Zhang CY; Baffy G; Perret P; Krauss S; Peroni O; Grujic D; Hagen T; Vidal-Puig AJ; Boss O; Kim YB; Zheng XX; Wheeler MB; Shulman GI; Chan CB; Lowell BB. 2001. Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Cell 105(6):745-55. [PubMed: 11440717]  [MGI Ref ID J:75196]

Zhang F; Dey D; Branstrom R; Forsberg L; Lu M; Zhang Q; Sjoholm A. 2009. BLX-1002, a novel thiazolidinedione with no PPAR affinity, stimulates AMP-activated protein kinase activity, raises cytosolic Ca2+, and enhances glucose-stimulated insulin secretion in a PI3K-dependent manner. Am J Physiol Cell Physiol 296(2):C346-54. [PubMed: 19052259]  [MGI Ref ID J:146323]

Zhang LL; Yan Liu D; Ma LQ; Luo ZD; Cao TB; Zhong J; Yan ZC; Wang LJ; Zhao ZG; Zhu SJ; Schrader M; Thilo F; Zhu ZM; Tepel M. 2007. Activation of transient receptor potential vanilloid type-1 channel prevents adipogenesis and obesity. Circ Res 100(7):1063-70. [PubMed: 17347480]  [MGI Ref ID J:133914]

Zhang P; O'Loughlin L; Brindley DN; Reue K. 2008. Regulation of lipin-1 gene expression by glucocorticoids during adipogenesis. J Lipid Res 49(7):1519-28. [PubMed: 18362392]  [MGI Ref ID J:138464]

Zhang W; Lilja L; Mandic SA; Gromada J; Smidt K; Janson J; Takai Y; Bark C; Berggren PO; Meister B. 2006. Tomosyn is expressed in beta-cells and negatively regulates insulin exocytosis. Diabetes 55(3):574-81. [PubMed: 16505218]  [MGI Ref ID J:106861]

Zhang X; Zhang G; Zhang H; Karin M; Bai H; Cai D. 2008. Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell 135(1):61-73. [PubMed: 18854155]  [MGI Ref ID J:149873]

Zhou X; Benson KF; Ashar HR; Chada K. 1995. Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-C [see comments] Nature 376(6543):771-4. [PubMed: 7651535]  [MGI Ref ID J:28571]

Ziouzenkova O; Orasanu G; Sharlach M; Akiyama TE; Berger JP; Viereck J; Hamilton JA; Tang G; Dolnikowski GG; Vogel S; Duester G; Plutzky J. 2007. Retinaldehyde represses adipogenesis and diet-induced obesity. Nat Med 13(6):695-702. [PubMed: 17529981]  [MGI Ref ID J:121870]

Zyromski NJ; Mathur A; Pitt HA; Lu D; Gripe JT; Walker JJ; Yancey K; Wade TE; Swartz-Basile DA. 2008. A murine model of obesity implicates the adipokine milieu in the pathogenesis of severe acute pancreatitis. Am J Physiol Gastrointest Liver Physiol 295(3):G552-8. [PubMed: 18583460]  [MGI Ref ID J:141913]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX6
Room Number           AX8

Colony Maintenance

Diet Information	LabDiet® 5K20

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Supply Details

Standard Supply	Level 2. Up to 100 mice. Larger quantities or custom orders arranged upon request.
Supply Notes	This strain is available from some international Charles River Laboratories (CRL) breeding facilities in Japan and/or Europe. For more information, see the Worldwide Distributor List for JAX® Mice. Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

	Control
	Heterozygote from the colony
	Untyped from the colony
	000664 C57BL/6J
Considerations for Choosing Controls
USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
International - Control Pricing Information for Genetically Engineered Mutant Strains.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Fax: 1-207-288-6150
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Terms of Use

Terms of Use

General Terms and Conditions

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General inquiries

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phone:	207-288-6470
fax:	207-288-6655

JAX^® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. In purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.