Strain Name:

B6C3Fe a/a-Lmx1adr-J/J

Stock Number:

000636

Availability:

Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names B6C3Fe-a/a-Lmx1adr-J    (Changed: 15-DEC-04 )
Type Mutant Strain;
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Specieslaboratory mouse
H2 Haplotypek/b segregating
GenerationN10 F1

Appearance
black (may have white belly spot), circling, ataxic, short tail
Related Genotype: a/a Lmx1adr-J/Lmx1adr-J

black, unaffected
Related Genotype: a/a Lmx1adr-J/+ or a/a ?/+

Description
Lmx1a encodes a LIM homeodomain (LIM-hd) protein that is expressed in the roof plate along the neuraxis during CNS development. The Lmx1adr-J mutation replaces a conserved cysteine in the LIM1 domain of the protein with a tyrosine (Millonig et al. 2000).

Mice homozygous for Lmx1adr-Jare identifiable at birth by a thin filament extending from the end of the tail, which drops off within a few days, and a short or blunt tail. They may also have a head bleb. When fur develops, there may be a white belly spot. Lmx1adr-J/Lmx1adr-J mice are ataxic and hyperactive and have difficulty righting themselves, and they do not reproduce (Sweet and Wahlsten 1983). They also exhibit circling behavior, are deaf, and have inner ear and vertebral malformations (Manzanares et al. 2000).

Lmx1adr-J homozygotes exhibit defects of three classes of anatomic structures: the hindbrain roof plate, neural crest derived tissues, and the axial skeleton. Failure of roofplate development results in absence of dorsal interneurons of the spinal cord and of granule neurons of the cerebellar cortex and failure of the dorsal vertebral neural arches to form (Millonig et al. 2000). The cerebellum is smaller than normal, in some cases virtually absent, and exhibits disrupted foliation (Sweet and Wahlsten 1983; Sekiguchi et al. 1992). The cytoarchitectural organization of the neocortex, the hippocampus and the dentate gyrus is disrupted (Sekiguchi et al. 1992, 1993, 1994, 1996). Skeletal anomalies include abnormal neural crest derived cranial bones and improper fusion of cervical and thoracic vertebrae at the dorsal midline (Mananares et al. 2000). Deafness may be the consequence of "serious morphogenetic defects of the otic vesicle due to the dorsal neural tube abnormalities," perhaps augmented by "abnormal sensory and motor projections" in the region of rhombomeres 4-6 (Manzanares et al. 2000). Although they have no external or behavioral phenotype, 50% of heterozygotes exhibit histological pathology of the hippocampus qualitatively similar, but less extensive, than that of homozygotes (Patrylo et al. 1990).

Development
The Lmx1adr-J mutation, originally called sstJ and later known as drsst-J and as drJ, arose in the C3FeB6-A/Aw-J-ank colony in the Mouse Mutant Stocks Center at The Jackson Laboratory (Sweet and Wahlsten 1983). Since its discovery, it has been maintained by crossing ovary transplant recipients to B6C3Fe-a/a males; the black coat color of the present background makes it easy to distinguish pups derived from the transplanted ovary from any that might result from residual host ovarian tissue. Identification of the alleles for markers flanking Lmx1a in Lmx1adr-J/Lmx1adr-J progeny of B6C3Fe a/a-Lmx1adr-J/J pairs demonstrated that the mutation occurred on the C3H chromosome (Millonig et al. 2000).

Control Information

  Control
   Untyped from the colony
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   a allele
003879   B10;TFLe-a/a T tf/+ tf/J
001538   B6 x B6C3Sn a/A-T(1;9)27H/J
000916   B6 x B6C3Sn a/A-T(5;12)31H/J
000602   B6 x B6C3Sn a/A-T(8;16)17H/J
000618   B6 x FSB/GnEi a/a Ctslfs/J
000577   B6 x STOCK a Oca2p Hps5ru2 Ednrbs/J
000601   B6 x STOCK a/a T(7;18)50H/J
000592   B6 x STOCK T(2;4)13H a/J
000001   B6.C3 A/a Mgrn1md/J
000231   B6;C3Fe a/a-Csf1op/J
000785   B6;D2-a Es1e/EiJ
000604   B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J
002807   B6C3Fe a/a-Meox2fla/J
000224   B6C3Fe a/a-Scyl1mdf/J
001037   B6C3Fe a/a-Agtpbp1pcd/J
000221   B6C3Fe a/a-Alx4lst-J/J
002062   B6C3Fe a/a-Atp7aMo-8J/J
001756   B6C3Fe a/a-Cacng2stg/J
001815   B6C3Fe a/a-Col1a2oim/J
000209   B6C3Fe a/a-Dh/J
000211   B6C3Fe a/a-Dstdt-J/J
000210   B6C3Fe a/a-Edardl-J/J
000207   B6C3Fe a/a-Edaraddcr/J
000182   B6C3Fe a/a-Eef1a2wst/J
001278   B6C3Fe a/a-Glra1spd/J
000241   B6C3Fe a/a-Glrbspa/J
002875   B6C3Fe a/a-Hoxd13spdh/J
000304   B6C3Fe a/a-Krt71Ca Scn8amed-J/J
000226   B6C3Fe a/a-Largemyd/J
001280   B6C3Fe a/a-Lse/J
001573   B6C3Fe a/a-MitfMi/J
001035   B6C3Fe a/a-Napahyh/J
000181   B6C3Fe a/a-Otogtwt/J
000278   B6C3Fe a/a-Papss2bm Hps1ep Hps6ru/J
000205   B6C3Fe a/a-Papss2bm/J
002078   B6C3Fe a/a-Pcdh15av-2J/J
000246   B6C3Fe a/a-Pitpnavb/J
001430   B6C3Fe a/a-Ptch1mes/J
000506   B6C3Fe a/a-Qkqk/J
000235   B6C3Fe a/a-Relnrl/J
000237   B6C3Fe a/a-Rorasg/J
000290   B6C3Fe a/a-Sox10Dom/J
000230   B6C3Fe a/a-Tcirg1oc/J
003612   B6C3Fe a/a-Trak1hyrt/J
001512   B6C3Fe a/a-Ttnmdm/J
001607   B6C3Fe a/a-Unc5crcm/J
000005   B6C3Fe a/a-Wc/J
000243   B6C3Fe a/a-Wnt1sw/J
000248   B6C3Fe a/a-Xpl/J
001750   B6C3Fe a/a-XsJ/J
000624   B6C3Fe a/a-anx/J
008044   B6C3Fe a/a-bpck/J
003020   B6C3Fe a/a-dep/J
002018   B6C3Fe a/a-din/J
002339   B6C3Fe a/a-nma/J
000240   B6C3Fe a/a-soc/J
000063   B6C3Fe a/a-sy/J
001055   B6C3Fe a/a-tip/J
000245   B6C3Fe a/a-tn/J
000296   B6C3Fe-a/a Hoxa13Hd Mcoln3Va-J/J
000019   B6C3Fe-a/a-Itpr1opt/J
001022   B6C3FeF1/J a/a
006450   B6EiC3 a/A-Vss/GrsrJ
000971   B6EiC3 a/A-Och/J
000551   B6EiC3 a/A-Tbx15de-H/J
000557   B6EiC3-+ a/LnpUl A/J
000503   B6EiC3Sn a/A-Gy/J
001811   B6EiC3Sn a/A-Otcspf-ash/J
002343   B6EiC3Sn a/A-Otcspf/J
000391   B6EiC3Sn a/A-Pax6Sey-Dey/J
001924   B6EiC3Sn a/A-Ts(1716)65Dn
001923   B6EiC3Sn a/A-Ts(417)2Lws Tim/J
000225   C3FeLe.B6 a/a-Ptpn6me/J
008425   C3FeLe.B6-a Trl/J
000198   C3FeLe.B6-a/J
000291   C3FeLe.Cg-a/a Hm KitlSl Krt71Ca-J/J
001886   C3HeB/FeJLe a/a-gnd/J
000584   C57BL/6J-+ T(1;2)5Ca/a +/J
000284   CWD/LeJ
000670   DBA/1J
000671   DBA/2J
001057   HPT/LeJ
000260   JGBF/LeJ
000265   MY/HuLeJ
000308   SSL/LeJ
000994   STOCK a Myo5ad Mregdsu/J
000064   STOCK a Tyrp1b Sisi/J
002238   STOCK a Tyrp1b shmy/J
001433   STOCK a skt/J
000579   STOCK a tp/J
000319   STOCK a us/J
002648   STOCK a/a Cln6nclf/J
000317   STOCK a/a Egfrwa2/J
000302   STOCK a/a MitfMi-wh +/+ Itpr1opt/J
000286   STOCK a/a Myo5ad fd/+ +/J
000206   STOCK a/a Tyrc-h/J
001432   STOCK a/a Tyrp1b sks/Tyrp1b +/J
000281   STOCK a/a ma Flgft/ma Flgft/J
000312   STOCK stb + a/+ Fignfi a/J
000596   STOCK T(2;11)30H/+ x AEJ-a Gdf5bp-H/J or A/J-a Gdf5bp-J/J
000970   STOCK T(2;16)28H A/T(2;16)28H a/J
000590   STOCK T(2;4)1Sn a/J
000594   STOCK T(2;8)26H a/T(2;8)26H a Tyrp1+/Tyrp1b/J
000623   TR/DiEiJ
View Strains carrying   a     (104 strains)

Strains carrying other alleles of Lmx1a
004202   B6.C3 Pde6brd1 Hps4le/+ +-Lmx1adr-8J/J
002624   B6.C3-Lmx1adr-6J/J
View Strains carrying other alleles of Lmx1a     (2 strains)

Strains carrying other alleles of a
003301   (C57BL/6J x C3H-Eya1bor)F1/J
000251   AEJ.Cg-ae +/a Gdf5bp-H/J
000202   AEJ/Gn-bd/J
000199   AEJ/GnLeJ
000433   B10.C-H3c H13? A/(28NX)SnJ
000427   B10.CE-H13b Aw/(30NX)SnJ
000423   B10.KR-H13? A/SnJ
000420   B10.LP-H13b Aw/Sn
000477   B10.PA-Pldnpa H3e at/SnJ
000419   B10.UW-H3b we Pax1un at/SnJ
000593   B6 x B6CBCa Aw-J/A-Grid2Lc T(2;6)7Ca MitfMi-wh/J
000502   B6 x B6CBCa Aw-J/A-Myo5aflr Gnb5flr/J
000599   B6 x B6CBCa Aw-J/A-T(5;13)264Ca KitW-v/J
002083   B6 x B6EiC3 a/A-T(7;16)235Dn/J
000507   B6 x B6EiC3 a/A-Otcspf/J
003759   B6 x B6EiC3Sn a/A-T(10;16)232Dn/J
002071   B6 x B6EiC3Sn a/A-T(11;17)202Dn/J
002113   B6 x B6EiC3Sn a/A-T(11A2;16B3)238Dn/J
002068   B6 x B6EiC3Sn a/A-T(11B1;16B5)233Dn/J
002069   B6 x B6EiC3Sn a/A-T(14E4or5;16B5)225Dn/J
001926   B6 x B6EiC3Sn a/A-T(15;16)198Dn/J
001832   B6 x B6EiC3Sn a/A-T(15E;16B1)60Dn/J
003758   B6 x B6EiC3Sn a/A-T(16C3-4;17A2)65Dn/J
001833   B6 x B6EiC3Sn a/A-T(1C2;16C3)45Dn/J
001903   B6 x B6EiC3Sn a/A-T(6F;18C)57Dn/J
001535   B6 x B6EiC3Sn a/A-T(8A4;12D1)69Dn/J
001831   B6 x B6EiC3Sn a/A-T(8C3;16B5)164Dn/J
002016   B6(Cg)-Aw-J EdaTa-6J Chr YB6-Sxr/EiJ
000552   B6-Aw-J-EdaTa-6J.Cg-Sxr
001730   B6-Aw-J-EdaTa-6J.Cg-Sxrb Hya-/J
000841   B6-Aw-J.CBy-EdaTa-By/J
001809   B6-Aw-J.Cg-EdaTa-6J +/+ ArTfm/J
000600   B6-Gpi1b x B6CBCa Aw-J/A-T(7;15)9H Gpi1a/J
000769   B6.C/(HZ18)By-at-44J/J
000203   B6.C3-Aiy/a/J
000017   B6.C3-Avy/J
001572   B6.C3-am-J/J
000628   B6.CE-A Amy1b Amy2a5b/J
000021   B6.Cg-Ay/J
100409   B6129PF1/J-Aw-J/Aw
004200   B6;CBACa Aw-J/A-Npr2cn-2J/GrsrJ
000505   B6C3 Aw-J/A-Mutedmu/J
000604   B6C3 a/A-T(10;13)199H +/+ Lystbg-J/J or Lystbg-2J/J
000065   B6C3Fe a/a-we Pax1un at/J
000314   B6CBACa Aw-J/A-EdaTa/J-XO
000501   B6CBACa Aw-J/A-Aifm1Hq/J
001046   B6CBACa Aw-J/A-Grid2Lc/J
000500   B6CBACa Aw-J/A-Gs/J
002703   B6CBACa Aw-J/A-Hydinhy3/J
000247   B6CBACa Aw-J/A-Kcnj6wv/J
000287   B6CBACa Aw-J/A-Plp1jp EdaTa/J
000515   B6CBACa Aw-J/A-SfnEr/J
000242   B6CBACa Aw-J/A-spc/J
000288   B6CBACa Aw-J/A-we a Mafbkr/J
001201   B6CBACaF1/J-Aw-J/A
001752   B6CBCa Aw-J/A-T(7;15)9H/J
006450   B6EiC3 a/A-Vss/GrsrJ
000557   B6EiC3-+ a/LnpUl A/J
000504   B6EiC3Sn a/A-Cacnb4lh/J
000553   B6EiC3Sn a/A-Egfrwa2 Wnt3avt/J
001811   B6EiC3Sn a/A-Otcspf-ash/J
002343   B6EiC3Sn a/A-Otcspf/J
001923   B6EiC3Sn a/A-Ts(417)2Lws Tim/J
001875   B6EiC3SnF1/J
000200   C3FeB6 A/Aw-J-Ankank/J
000638   C3FeB6 A/Aw-J-Spnb4qv-J/J
001203   C3FeB6F1/J A/Aw-J
001272   C3H/HeSnJ-Ahvy/J
000099   C3HeB/FeJ-Avy/J
000338   C57BL/6J Aw-J-EdaTa-6J/J
000258   C57BL/6J-Ai/a/J
000774   C57BL/6J-Asy/a/J
000569   C57BL/6J-Aw-J-EdaTa +/+ ArTfm/J
000051   C57BL/6J-Aw-J/J
000055   C57BL/6J-at-33J/J
000070   C57BL/6J-atd/J
002468   KK.Cg-Ay/J
000262   LS/LeJ
000283   LT.CAST-A/J
001759   STOCK A Tyrc Sha/J
001427   STOCK Aw us/J
View Strains carrying other alleles of a     (81 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms
      assigned by genotype

Lmx1adr-J/Lmx1a+

        B6.Cg-Lmx1adr-J
  • pigmentation phenotype
  • belly spot (MGI Ref ID J:63181)
    • in C57BL/6 background, a white patch of variable size in the coat on the belly
    • in C57BL/6 background, white spotting trait became fully penetrant
  • skin/coat/nails phenotype
  • belly spot (MGI Ref ID J:63181)
    • in C57BL/6 background, a white patch of variable size in the coat on the belly
    • in C57BL/6 background, white spotting trait became fully penetrant

Lmx1adr-J/Lmx1adr-J

        B6.Cg-Lmx1adr-J
  • lethality-postnatal
  • postnatal lethality (MGI Ref ID J:63181)
    • shorter life span than wild-type in original mixed background
    • in C57BL/6 background, no live homozygotes are generated

Lmx1adr-J/Lmx1adr-J

        involves: C3H * C57BL/6
  • behavior/neurological phenotype
  • circling (MGI Ref ID J:63181)
  • head tossing (MGI Ref ID J:63181)
  • hearing/vestibular/ear phenotype
  • circling (MGI Ref ID J:63181)
  • deafness (MGI Ref ID J:63181)
  • head tossing (MGI Ref ID J:63181)
  • pigmentation phenotype
  • belly spot (MGI Ref ID J:63181)
    • a complete white belt around trunk with some variability
  • skin/coat/nails phenotype
  • belly spot (MGI Ref ID J:63181)
    • a complete white belt around trunk with some variability
  • lethality-postnatal
  • postnatal lethality (MGI Ref ID J:63181)
    • shorter life span than wild-type in original mixed background
    • initial breeding experiments in mixed background generated many live born homozygous pups
  • nervous system phenotype
  • abnormal cerebellum morphology (MGI Ref ID J:1460)
    • abnormal cerebellum development (MGI Ref ID J:1460)
      • the cerebellum is almost completely absent
      • abnormal cerebellar foliation (MGI Ref ID J:1460)
        • disruptions in foliation are found
        • there are mixtures of normal and abnormal laminated structure
        • islands of both granule and Purkinje cells or just granule cells are observed
  • abnormal glossopharyngeal ganglion morphology (MGI Ref ID J:63181)
    • much reduced glossopharyngeal ganglion
  • abnormal glossopharyngeal nerve morphology (MGI Ref ID J:63181)
    • an accessory branch originating in the glossopharyngeal/vagus region projects abnormally
  • abnormal hippocampus CA3 region morphology (MGI Ref ID J:1460)
    • pyramidal layer forms widely dispersed arrangements in this area
    • there is aberrant cholinergic activity
  • abnormal hippocampus development (MGI Ref ID J:1460)
  • abnormal hippocampus pyramidal cell layer (MGI Ref ID J:1460)
    • forms widely dispersed arrangements in CA3 region
    • there are ectopically located pyramidal cells in the stratum radiatum and stratum oriens
    • abnormal acetylcholinesterase activity is found in the ectopic pyramidal cells
  • abnormal rhombomere morphology (MGI Ref ID J:63181)
    • significant changes in the shape of rhombomeres 3, 4, and 5 are observed in homozygote embryos
    • however, hindbrain segmentation is not affected
  • abnormal roof plate morphology (MGI Ref ID J:63181)
    • defective roof plate formation in the hindbrain
  • spina bifida (MGI Ref ID J:63181)
    • in vertebrae T9-T13
  • craniofacial phenotype
  • abnormal interparietal bone morphology (MGI Ref ID J:63181)
    • the shape and ossification is severely disrupted
  • abnormal parietal bone morphology (MGI Ref ID J:63181)
    • the shape of the parietal bone is affected
    • highly disorganized lamboid suture
  • skeleton phenotype
  • abnormal interparietal bone morphology (MGI Ref ID J:63181)
    • the shape and ossification is severely disrupted
  • abnormal parietal bone morphology (MGI Ref ID J:63181)
    • the shape of the parietal bone is affected
    • highly disorganized lamboid suture
  • abnormal vertebral arch development (MGI Ref ID J:63181)
    • neural arches in C1 fail to form along the dorsal midline
    • delay in fusion of the arches in C2 and C3
    • failure in dorsal fusion of vertebrae T9-T13 causing grossly altered neural arches
  • synostosis (MGI Ref ID J:63181)
    • occasional synostosis of the cranial vault along the interface of the interparietal and supraoccipital bone
    • responsible for the blebbing on the head seen in live animals
  • cellular phenotype
  • abnormal cell physiology (MGI Ref ID J:14476)
    • an abnormal distribution of acetylcholinesterase is found in the hippocampus
    • abnormal cell migration (MGI Ref ID J:1460)
      • abnormal neuronal migration contributes to abnormal cerebellum development
    • abnormal cell proliferation (MGI Ref ID J:1460)
      • disruption of cell proliferation contributes to abnormal cerebellum development
  • embryogenesis phenotype
  • abnormal rhombomere morphology (MGI Ref ID J:63181)
    • significant changes in the shape of rhombomeres 3, 4, and 5 are observed in homozygote embryos
    • however, hindbrain segmentation is not affected
  • abnormal roof plate morphology (MGI Ref ID J:63181)
    • defective roof plate formation in the hindbrain
  • spina bifida (MGI Ref ID J:63181)
    • in vertebrae T9-T13

Lmx1adr-J/Lmx1adr-J

        C3FeB6 A/Aw-J-Ankank Lmx1adr-J
  • limbs/digits/tail phenotype
  • short tail (MGI Ref ID J:13949)
    • a tiny filament at the tip of the tail seen at birth disappears by 2 days after birth leaving either a short tail or distinctly blunted tail
  • nervous system phenotype
  • abnormal cerebellar foliation (MGI Ref ID J:13949)
  • small cerebellum (MGI Ref ID J:13949)
  • behavior/neurological phenotype
  • altered righting response (MGI Ref ID J:13949)
    • a delayed development of the righting reflex
  • hyperactivity (MGI Ref ID J:13949)
  • pigmentation phenotype
  • belly spot (MGI Ref ID J:13949)
    • white belly spot and feet
  • skin/coat/nails phenotype
  • belly spot (MGI Ref ID J:13949)
    • white belly spot and feet
  • lethality-postnatal
  • postnatal lethality (MGI Ref ID J:13949)
    • preweaning mortality is high
  • reproductive system phenotype
  • infertility (MGI Ref ID J:13949)

Lmx1adr-J/Lmx1adr-J

        involves: C3HeB/Fe * C57BL/6
  • nervous system phenotype
  • abnormal cerebellum development (MGI Ref ID J:152673)
    • at E12.5, reduced proliferation is observed in the cerebellar anlage
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Lmx1adr-J related

Developmental Biology Research
Craniofacial and Palate Defects
Neural Tube Defects

Neurobiology Research
Cerebellar Defects
Neural Tube Defects
Vestibular and Hearing Defects

Sensorineural Research
Vestibular and Hearing Defects

Genes & Alleles

Gene & Allele Information

 
Allele Symbol Lmx1adr-J
Allele Name dreher Jackson
Allele Type Spontaneous
Common Name(s) sstJ;
Strain of OriginC3FeB6 A/Aw-J-Ankank/J
Gene Symbol and Name Lmx1a, LIM homeobox transcription factor 1 alpha
Chromosome 1
Gene Common Name(s) LMX-1; LMX1; LMX1.1; MGC87616; dr; dreher; shaker short-tail; sst;
Molecular Note A G-to-A transition mutation results in a conserved cysteine to a tyrosine amino acid change in the LIM1 domain of the encoded protein. The conserved cysteine is thought to be required for coordination of zinc that is essential for the function of the LIM domain, and thus the transcriptional activity of the protein. [MGI Ref ID J:60593]
 
Allele Symbol a
Allele Name nonagouti
Allele Type Spontaneous

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Genotyping resources and troubleshooting

References

References

Additional References

Manzanares M; Trainor PA; Ariza-McNaughton L; Nonchev S; Krumlauf R. 2000. Dorsal patterning defects in the hindbrain, roof plate and skeleton in the dreher (dr(J)) mouse mutant Mech Dev 94(1-2):147-56. [PubMed: 10842066]  [MGI Ref ID J:63181]

Millen KJ; Millonig JH; Hatten ME. 2004. Roof plate and dorsal spinal cord dl1 interneuron development in the dreher mutant mouse. Dev Biol 270(2):382-92. [PubMed: 15183721]  [MGI Ref ID J:92188]

Sekiguchi M; Abe H; Nagato Y; Tanaka O; Guo H; Nowakowski RS. 1996. The abnormal distribution of mossy fiber bundles and morphological abnormalities in hippocampal formation of dreher(J) (dr(J)/dr(J))mouse. Brain Res Dev Brain Res 92(1):31-8. [PubMed: 8861720]  [MGI Ref ID J:32558]

Sekiguchi M; Abe H; Shimai K; Huang G; Inoue T; Nowakowski RS. 1994. Disruption of neuronal migration in the neocortex of the dreher mutant mouse. Brain Res Dev Brain Res 77(1):37-43. [PubMed: 8131261]  [MGI Ref ID J:17085]

Sekiguchi M; Nowakowski RS; Shimai K; Huang G; Inoue T; Abe H. 1993. Abnormal distribution of acetylcholinesterase activity in the hippocampal formation of the dreher mutant mouse. Brain Res 622(1-2):203-10. [PubMed: 8242357]  [MGI Ref ID J:14476]

Sekiguchi M; Shimai K; Guo H; Nowakowski RS. 1992. Cytoarchitectonic abnormalities in hippocampal formation and cerebellum of dreher mutant mouse. Brain Res Dev Brain Res 67(1):105-12. [PubMed: 1638738]  [MGI Ref ID J:1460]

Lmx1adr-J related

Bergstrom DE; Gagnon LH; Eicher EM. 1999. Genetic and physical mapping of the Dreher locus on mouse Chromosome 1 Genomics 59:291-9. [PubMed: 10444330]  [MGI Ref ID J:54765]

Chizhikov V; Steshina E; Roberts R; Ilkin Y; Washburn L; Millen KJ. 2006. Molecular definition of an allelic series of mutations disrupting the mouse Lmx1a (dreher) gene. Mamm Genome 17(10):1025-32. [PubMed: 17019651]  [MGI Ref ID J:115043]

Chizhikov VV; Lindgren AG; Currle DS; Rose MF; Monuki ES; Millen KJ. 2006. The roof plate regulates cerebellar cell-type specification and proliferation. Development 133(15):2793-804. [PubMed: 16790481]  [MGI Ref ID J:119033]

Chizhikov VV; Millen KJ. 2004. Control of roof plate formation by Lmx1a in the developing spinal cord. Development 131(11):2693-705. [PubMed: 15148302]  [MGI Ref ID J:91822]

Costa C; Harding B; Copp AJ. 2001. Neuronal migration defects in the Dreher (Lmx1a) mutant mouse: role of disorders of the glial limiting membrane. Cereb Cortex 11(6):498-505. [PubMed: 11375911]  [MGI Ref ID J:102081]

Koo SK; Hill JK; Hwang CH; Lin ZS; Millen KJ; Wu DK. 2009. Lmx1a maintains proper neurogenic, sensory, and non-sensory domains in the mammalian inner ear. Dev Biol 333(1):14-25. [PubMed: 19540218]  [MGI Ref ID J:152264]

Manzanares M; Trainor PA; Ariza-McNaughton L; Nonchev S; Krumlauf R. 2000. Dorsal patterning defects in the hindbrain, roof plate and skeleton in the dreher (dr(J)) mouse mutant Mech Dev 94(1-2):147-56. [PubMed: 10842066]  [MGI Ref ID J:63181]

Millen KJ; Millonig JH; Hatten ME. 2004. Roof plate and dorsal spinal cord dl1 interneuron development in the dreher mutant mouse. Dev Biol 270(2):382-92. [PubMed: 15183721]  [MGI Ref ID J:92188]

Millonig JH; Millen KJ; Hatten ME. 2000. The mouse Dreher gene Lmx1a controls formation of the roof plate in the vertebrate CNS [see comments] Nature 403(6771):764-9. [PubMed: 10693804]  [MGI Ref ID J:60593]

Mishima Y; Lindgren AG; Chizhikov VV; Johnson RL; Millen KJ. 2009. Overlapping function of Lmx1a and Lmx1b in anterior hindbrain roof plate formation and cerebellar growth. J Neurosci 29(36):11377-84. [PubMed: 19741143]  [MGI Ref ID J:152673]

Ono Y; Nakatani T; Sakamoto Y; Mizuhara E; Minaki Y; Kumai M; Hamaguchi A; Nishimura M; Inoue Y; Hayashi H; Takahashi J; Imai T. 2007. Differences in neurogenic potential in floor plate cells along an anteroposterior location: midbrain dopaminergic neurons originate from mesencephalic floor plate cells. Development 134(17):3213-25. [PubMed: 17670789]  [MGI Ref ID J:124270]

Patrylo PR; Nowakowski RS. 1994. Morphology and distribution of astrocytes in the molecular layer of the dentate gyrus in NZB/BlNJ, Dreher, and C57BL/6J mice. Glia 10(1):1-9. [PubMed: 8300188]  [MGI Ref ID J:28531]

Sekiguchi M; Abe H; Nagato Y; Tanaka O; Guo H; Nowakowski RS. 1996. The abnormal distribution of mossy fiber bundles and morphological abnormalities in hippocampal formation of dreher(J) (dr(J)/dr(J))mouse. Brain Res Dev Brain Res 92(1):31-8. [PubMed: 8861720]  [MGI Ref ID J:32558]

Sekiguchi M; Abe H; Shimai K; Huang G; Inoue T; Nowakowski RS. 1994. Disruption of neuronal migration in the neocortex of the dreher mutant mouse. Brain Res Dev Brain Res 77(1):37-43. [PubMed: 8131261]  [MGI Ref ID J:17085]

Sekiguchi M; Nowakowski RS; Shimai K; Huang G; Inoue T; Abe H. 1993. Abnormal distribution of acetylcholinesterase activity in the hippocampal formation of the dreher mutant mouse. Brain Res 622(1-2):203-10. [PubMed: 8242357]  [MGI Ref ID J:14476]

Sekiguchi M; Shimai K; Guo H; Nowakowski RS. 1992. Cytoarchitectonic abnormalities in hippocampal formation and cerebellum of dreher mutant mouse. Brain Res Dev Brain Res 67(1):105-12. [PubMed: 1638738]  [MGI Ref ID J:1460]

Sweet HO; Wahlsten D. 1983. Shaker short-tail (sst). Mouse News Lett 69:26.  [MGI Ref ID J:13949]

Health & husbandry

Health & Colony Maintenance Information

Currently there no information available for this strain. This may be due to the supply level of this strain.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations View International pricing
Price (US dollars $)
Cryorecovery Fee $1900.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Additional Supply Details

Pricing for International shipping destinations View USA Canada and Mexico pricing
Price (US dollars $)
Cryorecovery Fee $2470.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Additional Supply Details

Supply Details

Standard SupplyCryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
Supply Notes
  • Cryorecovery - Standard.
    We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

  • This strain is included in the Mouse Mutant Resource collection.
  • Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

  Control
   Untyped from the colony
 
  Considerations for Choosing Controls
  USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
  International - Control Pricing Information for Genetically Engineered Mutant Strains.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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Terms of Use

Terms of Use


General Terms and Conditions


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General inquiries

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phone:207-288-6470
fax:207-288-6655

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. In purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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