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Strain Name:

A/HeJ

Stock Number:

000645

Availability:

Level 4

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General Terms and Conditions

Strain Common Names      AHe;      A Heston;
Genes & Alleles   Hc;   Hc0;

Product Information

Strain Details

Type Inbred Strain
Additional information on Inbred Strains.
Mating SystemSibling x Sibling         (Female x Male)
Specieslaboratory mouse
H2 Haplotypea
GenerationF274 (03-JAN-08)

Appearance
albino
Related Genotype: a/a Tyrp1b/Tyrp1b Tyrc/Tyrc

Strain Description
Developed by LC Strong in 1921 from a cross between a Cold Spring Harbor albino and a Bagg albino, the A inbred strain is used widely used in cancer and immunology research. It is highly susceptible to induction of congenital cleft palate by cortisone. It has a high incidence of spontaneous lung adenomas and lung tumors readily develop in response to carcinogens. High percentage of mammary adenocarcinomas (a large proportion acinar type) develop in multiparous females. Rare spontaneous myoepitheliomas arising from myoepithelial cells of various exocrine glands have been observed in The Jackson Laboratory substrains.

A small percent (4%) of nonproductive males are hermaphrodites. An additional 17% of nonproductive males have abnormally small testes containing no sperm.

Mammalian Phenotype Terms assigned by genotype

  • reproductive system phenotype
  • small testis (MGI Ref ID J:136868)
    • in a minority of males
    • testicular hypoplasia (MGI Ref ID J:136868)
      • in a minority of males
  • true hermaphroditism (MGI Ref ID J:136868)
    • approximately 4% of males from non-productive breeding pairs are overt hermaphrodites and 17% have abnormally small testes and no epididymal sperm
  • endocrine/exocrine gland phenotype
  • small testis (MGI Ref ID J:136868)
    • in a minority of males
    • testicular hypoplasia (MGI Ref ID J:136868)
      • in a minority of males

    Gene & Allele Details

    Allele Symbol Hc0
    Allele Name deficient
    Common Name(s) C5-; C5-d; C5-def; C5-deficient; hco;
    Gene Symbol and Name Hc, hemolytic complement
    Chromosome 2
    Gene Common Name(s) C5; C5a; CPAMD4; FLJ17816; FLJ17822; He; MGC142298; RGD1561905;
    General Note

    This is an allele characteristic of various inbred mouse strains including the following: A/HeJ, AKR/J, DBA/2J, NZB/B1NJ, SWR/J, B10.D2/oSnJ

    Hc was identified as a candidate gene for Abhr2 in a microarray analysis of lung mRNA from A/J, C3H/HeJ, and (A/J x C3H/HeJ)F1 x A/J backcross animals. Hc genotype shows statistically significant correlation to allergen-induced bronchial hyperresponsive phenotype. The A/J allele contains a 2 bp deletion resulting in deficient Hc mRNA and protein production and is associated with susceptibility to allergen-induced bronchial hyperresponsiveness. (J:108211)

    Molecular Note A 2 base "TA" deletion at positions 62 and 63 of an 83 base pair exon near the 5' end of the gene is found in the following mouse strains: A/HeJ, AKR/J, DBA/2J, NZB/B1NJ, SWR/J, B10.D2/oSnJ. The consequence of this deletion is the creation of a stop codon starting four bases after the deletion. A truncated product of 216 amino acids is predicted as a result although contradictory reports exist that a larger pro-C5 protein may be synthesized. Nevertheless, macrophages from mouse strains carrying this allele do not secrete complement 5. [MGI Ref ID J:23983]

    Colony Maintenance

    Diet Information LabDiet® 5K52/5K67

    Related Strains

    A Strains
    000646   A/J
    000647   A/WySnJ
    View A Strains     (2 strains)

    Strains carrying   Hc0 allele
    000646   A/J
    000647   A/WySnJ
    000648   AKR/J
    000460   B10.D2-Hc0 H2d H2-T18c/o2SnJ
    000461   B10.D2-Hc0 H2d H2-T18c/oSnJ
    000657   CE/J
    000671   DBA/2J
    007048   DBA/2J-Gpnmb+/SjJ
    001800   FVB/NJ
    001491   FVB/NMob
    000674   I/LnJ
    001303   NOD.CB17-Prkdcscid/J
    001976   NOD/ShiLtJ
    000684   NZB/BlNJ
    000682   RF/J
    000688   ST/bJ
    000689   SWR/J
    View Strains carrying   Hc0     (17 strains)

    View Strains carrying other alleles of Hc     (5 strains)

    Phenotypic Data

    Mouse Phenome Database
    Mouse Phenome Database / SNP Facility
    Festing Inbred Strain Characteristics: A

    Additional Web Information

    Genetic Quality Control Annual Report
    JAX Notes, April 1988; 433. H-2 Haplotypes of Mice from Jackson Laboratory Production Colonies.
    JAX Notes, Summer 1992; 450. Myoepitheliomas in Inbred Laboratory Mice.
    JAX Notes, Winter 2006; 500. New Strain Characteristic Documented for Inbred Strain A/HeJ (Stock Number 000645)

    Animal Health Reports

    Room Number           MP13

    Research Applications

    This mouse can be used to support research in many areas including:

    Cancer Research
    Increased Tumor Incidence (Adenomas: lung)
    Increased Tumor Incidence (Mammary Gland Tumors: late onset)
    Increased Tumor Incidence (Other Tissues/Organs: lung)

    Developmental Biology Research
    Craniofacial and Palate Defects (congenital cleft palate)
    Lymphoid Tissue Defects (hematopoietic defects)

    Reproductive Biology Research
    Developmental Defects Affecting Gonads

    Research Tools
    Immunology and Inflammation Research (specific complement deficiency) (C5 complement)

    Hc0 related

    Immunology and Inflammation Research
    Immunodeficiency (specific complement deficiency)

    Research Tools
    Immunology and Inflammation Research (specific complement deficiency) (C5 complement)

    References

    Additional References

    Price and Supply Information

    Strain Name: A/HeJ
    Stock Number: 000645

    Price Details

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    Supply Details

    Standard SupplyLevel 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.
    Supply Notes Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
    Strains that must be genotyped are not available until five to seven weeks of age.
    This strain is included in the Mouse Mutant Resource collection.
    Genomic DNA is available for this strain from the Mouse DNA Resource.
    LicensingSee General Terms and Conditions below  

    General Terms and Conditions

    View JAX® Mice & Services Conditions of Use.

    The Jackson Laboratory's Genotype Promise

    The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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