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Strain Common Names	AK;
Genes & Alleles	Hc;   Hc0;   Obq3;   Obq3AKR/J;   Obq4;   Obq4AKR/J;   Rmcf;   Rmcfs;   hid;

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Product Information

Strain Details

Type Inbred Strain Additional information on Inbred Strains. Mating System Sibling x Sibling         (Female x Male) Species laboratory mouse H2 Haplotype k Generation F255 (03-JAN-08)

Appearance
albino
Related Genotype: a/a Tyr^c/Tyr^c Soat1^ald/Soat1^ald hid/hid

Strain Description
Originally inbred at the Rockefeller Institute, AKR mice are widely used in cancer research for their high leukemia incidence (60-90%) and in immunology as a source of the Thy1.1 (theta AKR) antigen. AKR/J mice are viremic from birth, and express the ecotropic retrovirus AKV in all tissues. The hair interior defect (hid) mutation, a strain characteristic of AKR mice, causes alterations in hair development that is only evident microscopically. Adrenocortical lipid depletion (ald) in AKR mice is caused by a mutation in sterol O-acyltransferase 1 (Soat1), and leads to a truncated SOAT1 protein. AKR/J mice are relatively resistant to aortic lesion formation on a semi-synthetic high fat diet and are hyporesponsive to diets containing high levels of fat and cholesterol.

Mammalian Phenotype Terms assigned by genotype hid/hid         AKR skin/coat/nails phenotype abnormal hair growth (MGI Ref ID J:15247) homozygotes can be ascertained only by microscopic examination of the hair distal regions of all hair types are especially affected all AKR strains are homozygous for this mutation morphology and arrangement of medullary cells are abnormal abnormal hair shaft morphology (MGI Ref ID J:15247) medullary cell abnormality effects calibre of hair shaft abnormal hair medulla (MGI Ref ID J:15247) medulla morphology and arrangement are abnormal random and tightly packed medullary cells produce irregularities of hair shaft calibre

Gene & Allele Details

Allele Symbol		Hc0
Allele Name		deficient
Common Name(s)		C5-; C5-d; C5-def; C5-deficient; hco;
Gene Symbol and Name		Hc, hemolytic complement
Chromosome		2
Gene Common Name(s)		C5; C5a; CPAMD4; FLJ17816; FLJ17822; He; MGC142298; RGD1561905;
General Note		This is an allele characteristic of various inbred mouse strains including the following: A/HeJ, AKR/J, DBA/2J, NZB/B1NJ, SWR/J, B10.D2/oSnJ Hc was identified as a candidate gene for Abhr2 in a microarray analysis of lung mRNA from A/J, C3H/HeJ, and (A/J x C3H/HeJ)F1 x A/J backcross animals. Hc genotype shows statistically significant correlation to allergen-induced bronchial hyperresponsive phenotype. The A/J allele contains a 2 bp deletion resulting in deficient Hc mRNA and protein production and is associated with susceptibility to allergen-induced bronchial hyperresponsiveness. (J:108211)
Molecular Note		A 2 base "TA" deletion at positions 62 and 63 of an 83 base pair exon near the 5' end of the gene is found in the following mouse strains: A/HeJ, AKR/J, DBA/2J, NZB/B1NJ, SWR/J, B10.D2/oSnJ. The consequence of this deletion is the creation of a stop codon starting four bases after the deletion. A truncated product of 216 amino acids is predicted as a result although contradictory reports exist that a larger pro-C5 protein may be synthesized. Nevertheless, macrophages from mouse strains carrying this allele do not secrete complement 5. [MGI Ref ID J:23983]
Allele Symbol		Obq3AKR/J
Allele Name		AKR/J
Strain of Origin		AKR/J
Gene Symbol and Name		Obq3, obesity QTL 3
Chromosome		2
General Note		Obq3 exhibits an additive mode of inheritance.
Molecular Note		This allele confers increased adiposity in male animals compared to C57L/J. [MGI Ref ID J:39947]
Allele Symbol		Obq4AKR/J
Allele Name		AKR/J
Strain of Origin		AKR/J
Gene Symbol and Name		Obq4, obesity QTL 4
Chromosome		17
General Note		Obq4 may also be consistent with an additive mode of inheritance.
Allele Symbol		Rmcfs
Allele Name		MCF sensitive
Gene Symbol and Name		Rmcf, resistance to MCF virus
Chromosome		5
Allele Symbol		hid
Allele Name		hair interior defect
Strain of Origin		AKR

Colony Maintenance

Diet Information	LabDiet® 5K52/5K67

Related Strains

AKR Strains

002720

AKR/CumJ

View AKR Strains     (1 strain)

Strains carrying   Hc⁰ allele

000645	A/HeJ
000646	A/J
000647	A/WySnJ
000460	B10.D2-Hc0 H2d H2-T18c/o2SnJ
000461	B10.D2-Hc0 H2d H2-T18c/oSnJ
000657	CE/J
000671	DBA/2J
007048	DBA/2J-Gpnmb+/SjJ
001800	FVB/NJ
001491	FVB/NMob
000674	I/LnJ
001303	NOD.CB17-Prkdcscid/J
001976	NOD/ShiLtJ
000684	NZB/BlNJ
000682	RF/J
000688	ST/bJ
000689	SWR/J

View Strains carrying   Hc⁰     (17 strains)

Strains carrying   Rmcf^s allele

000646	A/J
000779	AKXD14/TyJ
000780	AKXD23/TyJ
000764	AKXD27/TyJ
000777	AKXD6/TyJ
000667	C57BR/cdJ
000668	C57L/J
000669	C58/J
000682	RF/J
000644	SEA/GnJ
000686	SJL/J
000688	ST/bJ

View Strains carrying   Rmcf^s     (12 strains)

Strains carrying other alleles of Hc

000470	AK.M-H2m H2-T18a/nSnJ
005308	B10.Cg-H2d Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
000463	B10.D2-Hc1 H2d H2-T18c/nSnJ
003147	B10.D2-Hc1 H2d H2-T18c/nSnJ-Tg(DO11.10)10Dlo/J
004306	NOD.CBALs-Hc1/LtJ

View Strains carrying other alleles of Hc     (5 strains)

Strains carrying other alleles of Obq3

000668

C57L/J

View Strains carrying other alleles of Obq3     (1 strain)

Strains carrying other alleles of Obq4

000668

C57L/J

View Strains carrying other alleles of Obq4     (1 strain)

Strains carrying other alleles of Rmcf

000690	129P3/J
000765	AKXD13/TyJ
000954	AKXD15/TyJ
001093	AKXD18/TyJ
000947	AKXD22/TyJ
000763	AKXD9/TyJ
000654	CBA/CaJ
000670	DBA/1J

View Strains carrying other alleles of Rmcf     (8 strains)

Phenotypic Data

Mouse Phenome Database
Mouse Phenome Database / SNP Facility
Festing Inbred Strain Characteristics: AKR

Additional Web Information

Genetic Quality Control Annual Report
JAX^® NOTES, April 1988; 433. H-2 Haplotypes of Mice from Jackson Laboratory Production Colonies.
JAX^® NOTES, Winter 2006; 504. JAX^® Mice: the Gold Standard Just Got Better.

Animal Health Reports

Room Number           MP16

Research Applications

This mouse can be used to support research in many areas including:

Cancer Research
Increased Tumor Incidence (Leukemia: lymphatic)

Cardiovascular Research
Atherosclerosis (Soat1^ald)
Diet-Induced Atherosclerosis (Relatively Resistant)

Developmental Biology Research
Lymphoid Tissue Defects (hematopoietic defects)

Diabetes and Obesity Research
Hyperglycemia (diet-induced, moderate)
Obesity With Diabetes (diet-induced)
Type 2 Diabetes (NIDDM) (diet-induced)

Endocrine Deficiency Research
Adrenal Cortex Defects
Hypothalamus/Pituitary Defects (Soat1^ald)

Internal/Organ Research
Adrenal Cortex Defects

Metabolism Research
Enzyme Deficiency

Neurobiology Research
Vestibular and Hearing Defects (Age related hearing loss)

Hc⁰ related

Immunology and Inflammation Research
Immunodeficiency (specific complement deficiency)

Research Tools
Immunology and Inflammation Research (specific complement deficiency) (C5 complement)

References

Selected Reference(s)

Doering CH; Shire JG; Kessler S; Clayton RB. 1973. Genetic and biochemical studies of the adrenal lipid depletion phenotype in mice. Biochem Genet 8(1):101-11. [PubMed: 4348256]  [MGI Ref ID J:5333]

Jiao S; Cole TG; Kitchens RT; Pfleger B; Schonfeld G. 1990. Genetic heterogeneity of plasma lipoproteins in the mouse: control of low density lipoprotein particle sizes by genetic factors. J Lipid Res 31(3):467-77. [PubMed: 1971301]  [MGI Ref ID J:15484]

Kirk EA; Moe GL; Caldwell MT; Lernmark JA; Wilson DL; LeBoeuf RC. 1995. Hyper- and hypo-responsiveness to dietary fat and cholesterol among inbred mice: searching for level and variability genes. J Lipid Res 36(7):1522-32. [PubMed: 7595076]  [MGI Ref ID J:28648]

Meiner VL; Welch CL; Cases S; Myers HM; Sande E; Lusis AJ; Farese RV Jr. 1998. Adrenocortical lipid depletion gene (ald) in AKR mice is associated with an acyl-CoA:cholesterol acyltransferase (ACAT) mutation. J Biol Chem 273(2):1064-9. [PubMed: 9422770]  [MGI Ref ID J:42073]

Molne K; Brabrand G. 1968. Spontaneous adrenocortical lipid depletion in mice. Relationship to general growth, degeneration of adrenal X zone, and maturation of seminiferous epithelium. Acta Pathol Microbiol Scand 72(4):478-90. [PubMed: 5693089]  [MGI Ref ID J:5089]

Nishina PM; Wang J; Toyofuku W; Kuypers FA; Ishida BY; Paigen B. 1993. Atherosclerosis and plasma and liver lipids in nine inbred strains of mice. Lipids 28(7):599-605. [PubMed: 8355588]  [MGI Ref ID J:13267]

Paigen B. 1995. Genetics of responsiveness to high-fat and high- cholesterol diets in the mouse. Am J Clin Nutr 62(2):458S-462S. [PubMed: 7625360]  [MGI Ref ID J:28248]

Paigen B; Ishida BY; Verstuyft J; Winters RB; Albee D. 1990. Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice. Arteriosclerosis 10(2):316-23. [PubMed: 2317166]  [MGI Ref ID J:22615]

Paigen B; Morrow A; Brandon C; Mitchell D; Holmes P. 1985. Variation in susceptibility to atherosclerosis among inbred strains of mice. Atherosclerosis 57(1):65-73. [PubMed: 3841001]  [MGI Ref ID J:109950]

Uelmen PJ; Oka K; Sullivan M; Chang CC; Chang TY; Chan L. 1995. Tissue-specific expression and cholesterol regulation of acylcoenzyme A:cholesterol acyltransferase (ACAT) in mice. Molecular cloning of mouse ACAT cDNA, chromosomal localization, and regulation of ACAT in vivo and in vitro. J Biol Chem 270(44):26192-201. [PubMed: 7592824]  [MGI Ref ID J:29712]

West DB; Boozer CN; Moody DL; Atkinson RL. 1992. Dietary obesity in nine inbred mouse strains. Am J Physiol 262(6 Pt 2):R1025-32. [PubMed: 1621856]  [MGI Ref ID J:1348]

Additional References

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Price and Supply Information

Strain Name:	AKR/J
Stock Number:	000648

Price Details

IMPORTANT NOTE: Prices are based on shipping destination. The shipping destinations are:

• USA, Canada and Mexico
• International

*Pricing for Shipping Destination selected:

        USA, Canada and Mexico

Price(s) in US dollars ($)		Genotype(s) Provided
3 weeks	$19.90		Female
4 weeks	$19.90		Female
5 weeks	$19.90		Female
6 weeks	$21.90		Female
7 weeks	$23.90		Female
8 weeks	$25.80		Female
9 weeks	$27.50		Female
10 weeks	$29.40		Female
3 weeks	$19.90		Male
4 weeks	$19.90		Male
5 weeks	$19.90		Male
6 weeks	$21.90		Male
7 weeks	$23.90		Male
8 weeks	$25.80		Male
9 weeks	$27.50		Male
10 weeks	$29.40		Male

Supply Details

Standard Supply	Level 2. Up to 100 mice. Larger quantities or custom orders arranged upon request.
Supply Notes	Histology and Tissue Collection Services are available for all JAX® Mice strains. For more information, please contact Customer Service at orderquest@jax.org or 1-800-422-6423. Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available. Strains that must be genotyped are not available until five to seven weeks of age. Genomic DNA is available for this strain from the Mouse DNA Resource.
Licensing	See General Terms and Conditions below

General Terms and Conditions

View JAX^® Mice & Services Conditions of Use.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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