Strain Name: |
BALB/cJ |
|---|---|
Stock Number: |
000651 |
Availability: | Level 1 |
General Terms and Conditions |
| Strain Common Names | C; |
| Genes & Alleles | Hld; |
Product Information
Strain Details
Type Inbred Strain Additional information on Inbred Strains. Mating System Sibling x Sibling (Female x Male) Species laboratory mouse H2 Haplotype d Generation F224 (03-JAN-08) Appearance
albino
Related Genotype: A/A Tyrp1b/Tyrp1b Tyrc/TyrcStrain Description
BALB/c mice are particularly well known for the production of plasmacytomas following injection with mineral oil forming the basis for the production of monoclonal antibodies. Although not all BALB/c substrains have been examined for plasmacytoma induction, substrains derived from the Andervont (An) lineage (which includes BALB/cByJ) typically are susceptible, while those descended from BALB/cJ are resistant (see: Potter M ,1985). Mammary tumor incidence is normally low but infection with mammary tumor virus by fostering to MMTV+ C3H mice dramatically increases tumor number and age of onset. BALB/c mice develop other cancers later in life including reticular neoplasms, primary lung tumors, and renal tumors. Rare spontaneous myoepitheliomas arising from myoepithelial cells of various exocrine glands have been observed in both BALB/cJ and BALB/cByJ substrains.White et al. reported a variation in thioglycolate medium-induced peritoneal leukocyte recruitment in 4 analyzed strains. The response of total leukocyte recruitment, from greatest to least, was C57BL/6J>BALB/c>CD1>129X1/SvJ. Variations were also found in the timeline of response and cell types most impacted.
Gene & Allele Details
| Allele Symbol | Hld | ||
|---|---|---|---|
| Allele Name | hippocampal lamination defect | ||
| Strain of Origin | BALB/cJ | ||
| General Note | Abnormal laminar organization of the pyramidal layer of the cerebellum, particularly in the proximal segment of the layer, occurs in the BALB/cJ strain (J:5787). A single gene, Hld for hippocampal lamination defect, was shown to cause this abnormality in a cross of BALB/c with C57BL/6 and in the CXB recombinant inbred strains (J:13989). In normal strains, the latest formed or youngest neurons migrate past the earlier formed or older neurons to a position in the pyramidal layer that is superficial to that of the older cells. In BALB/cJ, the positions are reversed, with the older cells lying superior to the younger ones (J:5787). Since mossy fibers form synapses primarily with the older cells, this aberrant pattern of cell migration in BALB/c leads to adifferent pattern of mossy-fiber synapses, easily visualized with Timm's stain (J:5486). The dendritic excrescences induced by contact with mossy fibers on late-generated pyramidal cells in +/+ mice occur at sites on both the apical and basal dendrites; in Hld/Hld mice, they occur in two sites on the apical dendrites only (J:12029). | ||
Colony Maintenance
| Diet Information | LabDiet® 5K52/5K67 |
|---|
Related Strains
BALB Strains
000650 BALB/cBy 001026 BALB/cByJ 001905 BALB/cGaJ 000921 BALB/cGrRkJ 001311 BALB/cWtEiJ View BALB Strains (5 strains)
001026 BALB/cByJ 000351 CXB1/ByJ 000353 CXB3/ByJ 000354 CXB4/ByJ 000355 CXB5/ByJ 000357 CXB7/ByJ
Phenotypic Data
Body Weight Information - JAX® Mice Strain BALB/cJ (000651)Mouse Phenome Database
(This chart reflects the typical correlation between body weight and age for mice maintained in production colonies at The Jackson Laboratory.)
Mouse Phenome Database - MHC H2 haplotype
Mouse Phenome Database - body weight
Mouse Phenome Database - cardiovascular
Mouse Phenome Database - disease susceptibility
Mouse Phenome Database - food and water intake
Mouse Phenome Database - hematology
Mouse Phenome Database / SNP Facility
Festing Inbred Strain Characteristics: BALB/c
NEW -- JAX® Physiological Data Summary
NEW -- JAX® Physiological Data Protocol
Additional Web Information
NEW -- JAX® Physiological Data Protocol
NEW -- JAX® Physiological Data Summary
Genetic Quality Control Annual Report
JAX Notes, April 1988; 433. H-2 Haplotypes of Mice from Jackson Laboratory Production Colonies.
JAX Notes, Fall 1990; 443. A Brief History of the Two Substrains of BALB/c, BALB/cJ, and BALB/cByJ Available from Animal Resources.
JAX Notes, Fall 1990; 443. Ulcerative Blepharitis and Periorbital Abscesses in BALB/cJ and BALB/cByJ Mice.
JAX Notes, Fall 2003; 491. JAX West Expansion
JAX Notes, January 1988; 432. Arthritis Models in the Mouse.
JAX Notes, July 1987; 430. BALB/cJ vs. BALB/cByJ.
JAX Notes, Spring 1990; 441. Imperforate Vagina and Mucometra in Mice.
JAX Notes, Spring 2003; 489. Malocclusion in the Laboratory Mouse.
JAX Notes, Summer 1992; 450. Myoepitheliomas in Inbred Laboratory Mice.
JAX Notes, Summer 2003; 490. Hydrocephalus in Laboratory Mice.
JAX Notes, Winter 2002; 488. Colony Expansions Completed for JAX® Mice Strains C57BL/6J and BALB/cJ.
JAX Notes, Winter 2006; 504. JAX® Mice: the Gold Standard Just Got Better.
Animal Health Reports
Room Number AX9
Room Number MP16
Room Number MP20
Room Number WR5
Research Applications
This mouse can be used to support research in many areas including:
Cancer Research
Increased Tumor Incidence (Mammary Gland Tumors: late onset)
Cardiovascular Research
Diet-Induced Atherosclerosis (Relatively Resistant)
Immunology and Inflammation Research
Inflammation
Neurobiology Research
Behavioral and Learning Defects (high anxiety)
Neurodevelopmental Defects (callosal agenesis, incomplete penetrance)
Research Tools
Cancer Research (monoclonal antibodies, myeloma and hybridoma production)
General Purpose
References
Selected Reference(s)
Additional ReferencesBentvelzen P; Daams JH; Hageman P; Calafat J. 1970. Genetic transmission of viruses that incite mammary tumor in mice. Proc Natl Acad Sci U S A 67(1):377-84. [PubMed: 4318784] [J:24803]
Ebbesen P. 1971. Reticulosarcoma and amyloid development in BALB/c mice inoculated with syngeneic cells from young and old donors. J Natl Cancer Inst 47(6):1241-5. [PubMed: 4941118] [J:24297]
Heston WE; Vlahakis G. 1971. Mammary tumors, plaques, and hyperplastic alveolar nodules in various combinations of mouse inbred strains and the different lines of the mammary tumor virus. Int J Cancer 7(1):141-8. [PubMed: 4322934] [J:24674]
Paigen B; Ishida BY; Verstuyft J; Winters RB; Albee D. 1990. Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice. Arteriosclerosis 10(2):316-23. [PubMed: 2317166] [J:22615]
Sundberg JP; Hanson CA; Roop DR; Brown KS; Bedigian HG. 1991. Myoepitheliomas in inbred laboratory mice. Vet Pathol 28(4):313-23. [PubMed: 1719689] [J:22767]
Price and Supply Information
| Strain Name: | BALB/cJ |
| Stock Number: | 000651 |
Price Details
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Supply Details
| Standard Supply | JAX Ready Strain® (Level 1). Most popular strains. Readily available in any quantity you need. |
|---|---|
| Supply Notes |
Males not available after seven weeks of age. Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available. Strains that must be genotyped are not available until five to seven weeks of age. Genomic DNA is available for this strain from the Mouse DNA Resource. |
| Licensing | See General Terms and Conditions below |
General Terms and Conditions
View JAX® Mice & Services Conditions of Use.
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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