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Type Inbred Strain; Additional information on Inbred Strains. Visit our online Nomenclature tutorial. Mating System Sibling x Sibling (Female x Male) 01-MAR-06 Species laboratory mouse H2 Haplotype k Generation F199 (03-JAN-08)
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agouti
Related Genotype: A/ADescription
The CBA inbred strain was initially bred for longevity and a low incidence of spontaneous mammary tumors (compared with C3H). Burdette and Strong reported that CBA mice were comparatively susceptible to tumor induction after a single subcutaneous injection of methylcholanthrene. The tumor types identified in this early work in CBA mice included spindle cell sarcoma, rhabdomyosarcoma, and epidermoid carcinoma. Strong and Smith reported finding benign hepatomas in aging CBA mice. Several groups confirmed this finding, and the majority of studies found a higher frequency of spontaneous hepatomas in males than in females.CBA/Ca mice are commonly used for leukemogenesis research because this strain has a low spontaneous incidence of leukemia but has a relatively high inducibility of myeloid leukemia in response to benzene and radiation exposure. Multiple reports using CBA, its F1 hybrids, and other strains, have indicated that deletions in a specific segment of chromosome 2 are linked to radiation and chemical induction of myeloid leukemia. This segment is reported to map to a 1 cM interval flanked by D2Mit126 and D2Mit185 which is homologous to human chromosome segment 11p11-12.
In addition, CBA/Ca mice have been used for the assessment of cytostatic drug combination protocols and have also been utilized successfully as hosts for childhood rhabdomyosarcoma xenografts, after thymectomy and irradiation. CBA/CaJ mice carry viral proteins Mtv8, Mtv9, and Mtv14.
Male CBA/Ca mice develop a mild adult onset diabetes-obesity syndrome that is characterized by hyperglycemia, hyperinsulinemia and insulin resistance. Pancreatic beta cells do not degenerate and circulating insulin levels remain high throughout life.
Unlike the CBA/J substrain, CBA/CaJ mice do not carry the retinal degeneration 1 allele (Pde6brd1). CBA/CaJ mice are not histocompatible with the CBA/J substrain (Green and Kaufer, 1965).
CBA Strains
001143 CBA/CaGnLeJ 000655 CBA/CaH-T(14;15)6Ca/J 001011 CBA/CaHN-Btkxid/J 000656 CBA/J View CBA Strains (4 strains)
Strains carrying Rmcfr allele
000690 129P3/J 000765 AKXD13/TyJ 000954 AKXD15/TyJ 001093 AKXD18/TyJ 000947 AKXD22/TyJ 000763 AKXD9/TyJ 000670 DBA/1J View Strains carrying Rmcfr (7 strains)
Strains carrying other alleles of Rmcf
000646 A/J 000648 AKR/J 000779 AKXD14/TyJ 000780 AKXD23/TyJ 000764 AKXD27/TyJ 000777 AKXD6/TyJ 000667 C57BR/cdJ 000668 C57L/J 000669 C58/J 000682 RF/J 000644 SEA/GnJ 000686 SJL/J 000688 ST/bJ View Strains carrying other alleles of Rmcf (13 strains)
Genetic Quality Control Annual Report
JAX® NOTES, April 1988; 433. H-2 Haplotypes of Mice from Jackson Laboratory Production Colonies.
JAX® NOTES, January 1988; 432. CBA Substrains Maintained at The Jackson Laboratory.
View Phenotypic Data
Phenotypic Data
Mouse Phenome Database
Festing Inbred Strain Characteristics: CBA
View Research Applications
Research Applications
This mouse can be used to support research in many areas including:
Cancer Research
Increased Tumor Incidence
Hepatomas
Leukemia
Lymphomas
Mammary Gland Tumors: late onset
Diabetes and Obesity Research
Hyperglycemia
adult onset, males
Hyperinsulinemia
adult onset, males
Insulin Resistance
males
Obesity With Diabetes
males
Type 2 Diabetes (NIDDM)
adult onset, males
Reproductive Biology Research
Meiotic Nondisjunction Studies
Research Tools
General Purpose
| Allele Symbol | Rmcfr | ||
|---|---|---|---|
| Allele Name | MCF resistant | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | multiple strains | ||
| Gene Symbol and Name | Rmcf, resistance to MCF virus | ||
| Chromosome | 5 | ||
| General Note |
This locus controls resistance and susceptibility of cells in tissue culture to infection by mink cell focus-forming murine leukemia viruses. The allele Rmcfr determines resistance and occurs in strains DBA/1, DBA/2, and CBA/Ca; the allele Rmcfs determines susceptibility and occurs in strains AKR/J, C57BL/6, BALB/c, CBA/J, NFS, NZB, 129/J, and many others. Heterozygotes are as resistant as the resistant parent or nearly so. Rmcf is different from and independent of Fv1,a locus that controls susceptibility to infection by ecotropic viruses. Rmcf is located on Chr 5 close to Hm near the centromeric end (J:7108). Rmcfr protects (AKR x CBA/Ca)F1 and (AKR x DBA/2)F1 hybrids from development of spontaneous thymic lymphomas and reduces the incidence of MCF-induced thymic lymphomas (J:7175). It also reduces susceptibility of cells of Sxvs/Sxvr mice to exogenous xenotropic viruses (J:7951). In addition, in strains susceptible to Friend virus-induced erythroleukemia, a condition thought to be due to the replication of MCF virus, Rmcfr increases resistance to the virus-induced erythroleukemia. It may cause resistance by coding for or regulating the production of an MCF-related envelope glycoprotein that blocks the receptor for MCF viruses (J:8074). This conclusion is reinforced by the findings of Buller et al. (J:8497), who showed that the Rmcfr allele contains an endogenous MCF gp70 env gene and that theRmcfs allele, at least in some strains (C57BL/6, CBA/J, and A/WySn), contains a xenotropic gp70 env gene. Presumably the MCF gp70 inhibits exogenous MCF infection in vitro by a mechanism of viral interference. | ||
| Molecular Note | This locus controls resistance of cells to infection by mink cell focus-forming murine leukemia viruses. The dominant r (resistance) allele is found in strains DBA/1, DBA/2 and CBA/Ca. | ||
Inbred mouse strains are maintained through sibling (sister x brother) matings; no genotyping required.
Genotyping resources and troubleshooting
Figueroa CD; Taberner PV. 1994. Pancreatic islet hypertrophy in spontaneous maturity onset obese-diabetic CBA/Ca mice. Int J Biochem 26(10-11):1299-303. [PubMed: 7851633] [MGI Ref ID J:23005]
Rithidech KN; Cronkite EP; Bond VP. 1999. Advantages of the CBA mouse in leukemogenesis research. Blood Cells Mol Dis 25(1):38-45. [PubMed: 10349512] [MGI Ref ID J:53730]
Rmcfr relatedBuller RS; Ahmed A; Portis JL. 1987. Identification of two forms of an endogenous murine retroviral env gene linked to the Rmcf locus. J Virol 61(1):29-34. [PubMed: 3023705] [MGI Ref ID J:8497]
Buller RS; Sitbon M; Portis JL. 1988. The endogenous mink cell focus-forming (MCF) gp70 linked to the Rmcf gene restricts MCF virus replication in vivo and provides partial resistance to erythroleukemia induced by Friend murine leukemia virus. J Exp Med 167(5):1535-46. [PubMed: 2835418] [MGI Ref ID J:27618]
Frankel WN; Stoye JP; Taylor BA; Coffin JM. 1989. Genetic identification of endogenous polytropic proviruses by using recombinant inbred mice. J Virol 63(9):3810-21. [PubMed: 2547997] [MGI Ref ID J:9925]
Hartley JW; Yetter RA; Morse HC 3d. 1983. A mouse gene on chromosome 5 that restricts infectivity of mink cell focus-forming recombinant murine leukemia viruses. J Exp Med 158(1):16-24. [PubMed: 6306133] [MGI Ref ID J:7108]
Jung YT; Lyu MS; Buckler-White A; Kozak CA. 2002. Characterization of a polytropic murine leukemia virus proviral sequence associated with the virus resistance gene Rmcf of DBA/2 mice. J Virol 76(16):8218-24. [PubMed: 12134027] [MGI Ref ID J:78083]
Kozak CA. 1985. Susceptibility of wild mouse cells to exogenous infection with xenotropic leukemia viruses: control by a single dominant locus on chromosome 1. J Virol 55(3):690-5. [PubMed: 2991590] [MGI Ref ID J:7951]
Rowe WP; Hartley JW. 1983. Genes affecting mink cell focus-inducing (MCF) murine leukemia virus infection and spontaneous lymphoma in AKR F1 hybrids. J Exp Med 158(2):353-64. [PubMed: 6224881] [MGI Ref ID J:7175]
Animal Health Reports
Room Number AX27
Colony Maintenance
Mating System Sibling x Sibling (Female x Male) 01-MAR-06 Diet Information LabDiet® 5K52/5K67
| Pricing for USA, Canada and Mexico shipping destinations |
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Weeks of Age Price (US dollars $) Gender 3-5 weeks $21.20 Female or Male 6 weeks $23.25 Female or Male 7 weeks $25.30 Female or Male 8 weeks $27.35 Female or Male 9 weeks $29.40 Female or Male 10 weeks $31.45 Female or Male
| Pricing for International shipping destinations |
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Weeks of Age Price (US dollars $) Gender 3-5 weeks $27.60 Female or Male 6 weeks $30.30 Female or Male 7 weeks $33.00 Female or Male 8 weeks $35.70 Female or Male 9 weeks $38.40 Female or Male 10 weeks $41.10 Female or Male
| Standard Supply | Level 2. Up to 100 mice. Larger quantities or custom orders arranged upon request. |
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