Go to JAX^® Mice Query Form

General Terms and Conditions

Strain Common Names	CBA Carter J;
Genes & Alleles	Rmcf;   Rmcfr;

---

Product Information

Strain Details

Type Inbred Strain Additional information on Inbred Strains. Mating System Sibling x Sibling         (Female x Male) Species laboratory mouse H2 Haplotype k Generation F199 (03-JAN-08)

Appearance
agouti
Related Genotype: A/A

Strain Description
The CBA inbred strain was initially bred for longevity and a low incidence of spontaneous mammary tumors (compared with C3H). Burdette and Strong reported that CBA mice were comparatively susceptible to tumor induction after a single subcutaneous injection of methylcholanthrene. The tumor types identified in this early work in CBA mice included spindle cell sarcoma, rhabdomyosarcoma, and epidermoid carcinoma. Strong and Smith reported finding benign hepatomas in aging CBA mice. Several groups confirmed this finding, and the majority of studies found a higher frequency of spontaneous hepatomas in males than in females.

CBA/Ca mice are commonly used for leukemogenesis research because this strain has a low spontaneous incidence of leukemia but has a relatively high inducibility of myeloid leukemia in response to benzene and radiation exposure. Multiple reports using CBA, its F1 hybrids, and other strains, have indicated that deletions in a specific segment of chromosome 2 are linked to radiation and chemical induction of myeloid leukemia. This segment is reported to map to a 1 cM interval flanked by D2Mit126 and D2Mit185 which is homologous to human chromosome segment 11p11-12.

In addition, CBA/Ca mice have been used for the assessment of cytostatic drug combination protocols and have also been utilized successfully as hosts for childhood rhabdomyosarcoma xenografts, after thymectomy and irradiation. CBA/CaJ mice carry viral proteins Mtv8, Mtv9, and Mtv14.

Male CBA/Ca mice develop a mild adult onset diabetes-obesity syndrome that is characterized by hyperglycemia, hyperinsulinemia and insulin resistance. Pancreatic beta cells do not degenerate and circulating insulin levels remain high throughout life.

Unlike the CBA/J substrain, CBA/CaJ mice do not carry the retinal degeneration 1 allele (Pde6b^rd1). CBA/CaJ mice are not histocompatible with the CBA/J substrain (Green and Kaufer, 1965).

Gene & Allele Details

Allele Symbol		Rmcfr
Allele Name		MCF resistant
Gene Symbol and Name		Rmcf, resistance to MCF virus
Chromosome		5

Colony Maintenance

Diet Information	LabDiet® 5K52/5K67

Related Strains

CBA Strains

001143	CBA/CaGnLeJ
000655	CBA/CaH-T(14;15)6Ca/J
001011	CBA/CaHN-Btkxid/J
000656	CBA/J

View CBA Strains     (4 strains)

Strains carrying   Rmcf^r allele

000690	129P3/J
000765	AKXD13/TyJ
000954	AKXD15/TyJ
001093	AKXD18/TyJ
000947	AKXD22/TyJ
000763	AKXD9/TyJ
000670	DBA/1J

View Strains carrying   Rmcf^r     (7 strains)

Strains carrying other alleles of Rmcf

000646	A/J
000648	AKR/J
000779	AKXD14/TyJ
000780	AKXD23/TyJ
000764	AKXD27/TyJ
000777	AKXD6/TyJ
000667	C57BR/cdJ
000668	C57L/J
000669	C58/J
000682	RF/J
000644	SEA/GnJ
000686	SJL/J
000688	ST/bJ

View Strains carrying other alleles of Rmcf     (13 strains)

Phenotypic Data

Mouse Phenome Database
Festing Inbred Strain Characteristics: CBA

Additional Web Information

Genetic Quality Control Annual Report
JAX Notes, April 1988; 433. H-2 Haplotypes of Mice from Jackson Laboratory Production Colonies.
JAX Notes, January 1988; 432. CBA Substrains Maintained at The Jackson Laboratory.

Animal Health Reports

Room Number           AX27

Research Applications

This mouse can be used to support research in many areas including:

Cancer Research
Increased Tumor Incidence (Hepatomas)
Increased Tumor Incidence (Leukemia)
Increased Tumor Incidence (Lymphomas)
Increased Tumor Incidence (Mammary Gland Tumors: late onset)

Diabetes and Obesity Research
Hyperglycemia (adult onset, males)
Hyperinsulinemia (adult onset, males)
Insulin Resistance (males)
Obesity With Diabetes (males)
Type 2 Diabetes (NIDDM) (adult onset, males)

Reproductive Biology Research
Meiotic Nondisjunction Studies

Research Tools
General Purpose

References

Selected Reference(s)

Figueroa CD; Taberner PV. 1994. Pancreatic islet hypertrophy in spontaneous maturity onset obese-diabetic CBA/Ca mice. Int J Biochem 26(10-11):1299-303. [PubMed: 7851633]  [MGI Ref ID J:23005]

Rithidech KN; Cronkite EP; Bond VP. 1999. Advantages of the CBA mouse in leukemogenesis research. Blood Cells Mol Dis 25(1):38-45. [PubMed: 10349512]  [MGI Ref ID J:53730]

Additional References

---

Price and Supply Information

Strain Name:	CBA/CaJ
Stock Number:	000654

Price Details

IMPORTANT NOTE: Prices are based on shipping destination. To view prices, select your shipping destination.

• USA, Canada and Mexico
• International

*NO Shipping Destination selected!

 

Supply Details

Standard Supply	Level 2. Up to 100 mice. Larger quantities or custom orders arranged upon request.
Supply Notes	Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available. Strains that must be genotyped are not available until five to seven weeks of age. Genomic DNA is available for this strain from the Mouse DNA Resource.
Licensing	See General Terms and Conditions below

General Terms and Conditions

View JAX^® Mice & Services Conditions of Use.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

---

Ordering and Purchasing Information

      Purchasing Information
      JAX^® Mice Orders
      Surgical Services

Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form

Go to JAX^® Mice Query Form