Strain Name: |
CBA/CaJ |
|---|---|
Stock Number: |
000654 |
Availability: | Level 2 |
General Terms and Conditions |
| Strain Common Names | CBA Carter J; |
| Genes & Alleles | Rmcf; Rmcfr; |
Type Inbred Strain Additional information on Inbred Strains. Mating System Sibling x Sibling (Female x Male) Species laboratory mouse H2 Haplotype k Generation F199 (03-JAN-08) Appearance
agouti
Related Genotype: A/AStrain Description
The CBA inbred strain was initially bred for longevity and a low incidence of spontaneous mammary tumors (compared with C3H). Burdette and Strong reported that CBA mice were comparatively susceptible to tumor induction after a single subcutaneous injection of methylcholanthrene. The tumor types identified in this early work in CBA mice included spindle cell sarcoma, rhabdomyosarcoma, and epidermoid carcinoma. Strong and Smith reported finding benign hepatomas in aging CBA mice. Several groups confirmed this finding, and the majority of studies found a higher frequency of spontaneous hepatomas in males than in females.CBA/Ca mice are commonly used for leukemogenesis research because this strain has a low spontaneous incidence of leukemia but has a relatively high inducibility of myeloid leukemia in response to benzene and radiation exposure. Multiple reports using CBA, its F1 hybrids, and other strains, have indicated that deletions in a specific segment of chromosome 2 are linked to radiation and chemical induction of myeloid leukemia. This segment is reported to map to a 1 cM interval flanked by D2Mit126 and D2Mit185 which is homologous to human chromosome segment 11p11-12.
In addition, CBA/Ca mice have been used for the assessment of cytostatic drug combination protocols and have also been utilized successfully as hosts for childhood rhabdomyosarcoma xenografts, after thymectomy and irradiation. CBA/CaJ mice carry viral proteins Mtv8, Mtv9, and Mtv14.
Male CBA/Ca mice develop a mild adult onset diabetes-obesity syndrome that is characterized by hyperglycemia, hyperinsulinemia and insulin resistance. Pancreatic beta cells do not degenerate and circulating insulin levels remain high throughout life.
Unlike the CBA/J substrain, CBA/CaJ mice do not carry the retinal degeneration 1 allele (Pde6brd1). CBA/CaJ mice are not histocompatible with the CBA/J substrain (Green and Kaufer, 1965).
| Allele Symbol | Rmcfr | ||
|---|---|---|---|
| Allele Name | MCF resistant | ||
| Gene Symbol and Name | Rmcf, resistance to MCF virus | ||
| Chromosome | 5 | ||
| Diet Information | LabDiet® 5K52/5K67 |
|---|
CBA Strains
001143 CBA/CaGnLeJ 000655 CBA/CaH-T(14;15)6Ca/J 001011 CBA/CaHN-Btkxid/J 000656 CBA/J View CBA Strains (4 strains)
Strains carrying Rmcfr allele
000690 129P3/J 000765 AKXD13/TyJ 000954 AKXD15/TyJ 001093 AKXD18/TyJ 000947 AKXD22/TyJ 000763 AKXD9/TyJ 000670 DBA/1J View Strains carrying Rmcfr (7 strains)
Strains carrying other alleles of Rmcf
000646 A/J 000648 AKR/J 000779 AKXD14/TyJ 000780 AKXD23/TyJ 000764 AKXD27/TyJ 000777 AKXD6/TyJ 000667 C57BR/cdJ 000668 C57L/J 000669 C58/J 000682 RF/J 000644 SEA/GnJ 000686 SJL/J 000688 ST/bJ View Strains carrying other alleles of Rmcf (13 strains)
Mouse Phenome Database
Festing Inbred Strain Characteristics: CBA
Genetic Quality Control Annual Report
JAX Notes, April 1988; 433. H-2 Haplotypes of Mice from Jackson Laboratory Production Colonies.
JAX Notes, January 1988; 432. CBA Substrains Maintained at The Jackson Laboratory.
Room Number AX27
Cancer Research
Increased Tumor Incidence (Hepatomas)
Increased Tumor Incidence (Leukemia)
Increased Tumor Incidence (Lymphomas)
Increased Tumor Incidence (Mammary Gland Tumors: late onset)
Diabetes and Obesity Research
Hyperglycemia (adult onset, males)
Hyperinsulinemia (adult onset, males)
Insulin Resistance (males)
Obesity With Diabetes (males)
Type 2 Diabetes (NIDDM) (adult onset, males)
Reproductive Biology Research
Meiotic Nondisjunction Studies
Research Tools
General Purpose
Selected Reference(s)
Additional ReferencesFigueroa CD; Taberner PV. 1994. Pancreatic islet hypertrophy in spontaneous maturity onset obese-diabetic CBA/Ca mice. Int J Biochem 26(10-11):1299-303. [PubMed: 7851633] [MGI Ref ID J:23005]
Rithidech KN; Cronkite EP; Bond VP. 1999. Advantages of the CBA mouse in leukemogenesis research. Blood Cells Mol Dis 25(1):38-45. [PubMed: 10349512] [MGI Ref ID J:53730]
| Strain Name: | CBA/CaJ |
| Stock Number: | 000654 |
IMPORTANT NOTE: Prices are based on shipping destination. To view prices, select your shipping destination.
| Standard Supply | Level 2. Up to 100 mice. Larger quantities or custom orders arranged upon request. |
|---|---|
| Supply Notes |
Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available. Strains that must be genotyped are not available until five to seven weeks of age. Genomic DNA is available for this strain from the Mouse DNA Resource. |
| Licensing | See General Terms and Conditions below |
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