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| C3H/HeJ mice are used as a general purpose strain in a wide variety of research areas including cancer, infectious disease, sensorineural, and cardiovascular biology research. A spontaneous mutation occurred in C3H/HeJ at the lipopolysaccharide response locus (mutation in toll-like receptor 4 gene, Tlr4Lps-d) making C3H/HeJ mice more resistant to endotoxin. C3H/HeJ (Tlr4Lps-d) mice are highly susceptible to infection by Gram-negative bacteria such as Salmonella enterica. | ||||||||||||||||||
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- Phenotype
- Genes & alleles
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Description
Strain Information
Former Names C3H/HeJ-Pde6brd1 (Changed: 19-MAR-08 ) Type Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Type Inbred Strain; Additional information on Inbred Strains. Visit our online Nomenclature tutorial. Mating System Sibling x Sibling (Female x Male) 01-MAR-06 Species laboratory mouse H2 Haplotype k Generation F263 (03-JAN-08)
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agouti
Related Genotype: A/AImportant Note
This strain does not carry mouse mammary tumor virus (MMTV). See JAX® NOTES, May 2000, No. 480. This strain is homozygous for retinal degeneration allele Pde6brd1, the defective lipopolysaccharide response allele Tlr4Lps-d, and for a chromosomal inversion on Chromosome 6.Description
C3H/HeJ mice are used as a general purpose strain in a wide variety of research areas including cancer, immunology and inflammation, sensorineural, and cardiovascular biology. C3H/HeJ mice and all other Jackson substrains are homozygous for the retinal degeneration 1 mutation (Pde6brd1), which causes blindness by weaning age. White belly spots, ranging in phenotype from a few white hairs to a defined spot are common in C3H/HeJ mice. There is also a high incidence of hepatomas in C3H mice (reportedly 72-91% in males at 14 months, 59% in virgin females, 30-38% in breeding females). Despite the lack of exogenous mouse mammary tumor virus (MMTV), virgin and breeding females may still develop some mammary tumors later in life. C3H/HeJ mice, fed an atherogenic diet (1.25% cholesterol, 0.5% cholic acid and 15% fat), fail to develop atherosclerotic aortic lesions in contrast to several highly susceptible strains of mice (e.g. C57BL/6J, Stock No. 000664; C57L/J, Stock No. 000668, C57BR/cdJ, Stock No. 000667, and SM/J, Stock No. 000687). C3H/HeJ mice spontaneously develop alopecia areata (AA) at a reported incidence of approximately 0.25% by 18 months of age. Alopecia areata can be surgically-induced by grafting a small piece of skin from an older, donor animal with AA onto a younger, isogenic C3H/HeJ recipient. Visit the JAX ® Surgical Model for Alopecia Areata Web page for more information on this surgically induced model.A spontaneous mutation occurred in C3H/HeJ at the lipopolysaccharide response locus (later identified as a mutation in the toll-like receptor 4 gene, Tlr4Lps-d) making C3H/HeJ mice endotoxin resistant. C3H/HeJ (Tlr4Lps-d) mice are highly susceptible to infection by Gram-negative bacteria such as Salmonella enterica. Mice infected with Salmonella exhibit delayed chemokine production, impaired nitric oxide generation and attenuated cellular immune responses. Mortality in infected mice appears to result from enhanced bacterial growth within the liver Kupffer cell network (Vazquez-Torres et al., 2004). The C3H/HeJ substrain is homozygous for an inversion on Chromosome 6 (symbol: In(6)1J). The inversion covers 20% of Chromosome 6 between D6Mit124 (~30.3 cM) and D6Mit150 (~51.0 cM), but results in no reported phenotype. Results from screening other C3H substrains and cryopreserved stock from C3H/HeJ suggest that the mutation arose after 1952. See JAX Notes, Fall 2003, No. 491. The spontaneous mutation, spike wave discharge 1 (spkw1), is present in C3H/HeJ, but not C3HeB/FeJ. Mice homozygous for this mutation exhibit a modest incidence of absence seizures.
Development
The C3H parent strain was developed by LC Strong in 1920 from a cross of a Bagg albino female with a DBA male followed by selection for high incidence of mammary tumors. This high incidence resulted from exogenous mouse mammary tumor virus (MMTV) transmitted through the mother's milk. The Jackson Laboratory maintains four C3H substrains, C3H/HeJ (Stock No. 000659), C3H/HeOuJ (Stock No. 000635), C3HeB/FeJ (Stock No. 000658) and C3H/HeSnJ (Stock No. 000661) that are now free of exogenous MMTV. C3H/HeJ and C3H/HeOuJ mice previously carried MMTV but were rederived in 1999 during planned efforts to increase the overall health status of the mice and the virus was not reintroduced. C3H/HeJ and C3H/HeOuJ substrains were separated in 1952 and are genetically very similar. However, a spontaneous mutation occurred in C3H/HeJ sometime between 1960 and 1968 at lipopolysaccharide response locus (mutation in toll-like receptor 4 gene, Tlr4lps) making C3H/HeJ mice endotoxin resistant while the other three C3H strains are endotoxin sensitive.
Related Strains
C3H Strains
005972 C3H/HeJBirLtJ 001824 C3H/HeJSxJ 000635 C3H/HeOuJ 000474 C3H/HeSn 000661 C3H/HeSnJ 000658 C3HeB/FeJ 001908 C3HfB/BiJ View C3H Strains (7 strains)
000645 A/HeJ 000646 A/J 000130 B6.C-H17c/(HW14)ByJ 000370 B6.C-H38c/(HW119)ByJ 001026 BALB/cByJ 000352 CXB2/ByJ 000353 CXB3/ByJ 000354 CXB4/ByJ 000355 CXB5/ByJ 000357 CXB7/ByJ
002930 C.C3-Tlr4Lps-d/J 005973 C3Bir.129P2(B6)-Il10C3Bir/LtJ 004326 C3Bir.129P2(B6)-Il10tm1Cgn/Lt 003968 C3Bir.129P2(B6)-Il10tm1Cgn/LtJ 005972 C3H/HeJBirLtJ
000648 AKR/J 002920 B6(D2N).Spretus-Ahrb-3/J 006203 B6.129(FVB)-Ahrtm3.1Bra/J 002831 B6.129-Ahrtm1Bra/J 000136 B6.C-H34c/(HW22)ByJ 002921 B6.D2N-Ahrd/J 002727 B6;129-Ahrtm1Bra/J 000664 C57BL/6J 000669 C58/J 000926 CAROLI/EiJ 000351 CXB1/ByJ 000356 CXB6/ByJ 002937 D2.B6-Ahrb-1/J 000671 DBA/2J 000677 MA/MyJ 000550 MOLF/EiJ 001146 SPRET/EiJ
004297 B6.CXB1-Pde6brd10/J 005252 B6EiC3Sn.BLiA-Ts(1716)65Dn/DnJ 003647 B6EiC3Sn.BLiAF1 002802 C3.BLiA Pde6b+-Krd/J 001979 C3A.BLiA-Pde6b+.O20-Prph2Rd2/J 001912 C3A.BLiA-Pde6b+/J 003648 C3Sn.BLiA-Pde6b+/Dn 004766 C57BL/6J-Pde6brd1-2J/J 004828 FVB.129P2-Pde6b+ Tyrc-ch/AntJ 004808 STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
007227 B6.B10ScN-Tlr4lps-del/JthJ 000029 BXD29-Tlr4lps-2J/J 003752 C57BL/10ScNJ
Additional Web Information
A Surgically Induced Model of Alopecia Areata.
C3H strains free of exogenous MMTV
Genetic Quality Control Annual Report
JAX® NOTES, April 1988; 433. H-2 Haplotypes of Mice from Jackson Laboratory Production Colonies.
JAX® NOTES, Fall 2003; 491. Chromosomal Inversion Discovered in C3H/HeJ Mice.
JAX® NOTES, January 1988; 432. Arthritis Models in the Mouse.
JAX® NOTES, July 1987; 430. LPS Responsiveness of C3H Substrains.
JAX® NOTES, July 1987; 430. Mammary Tumor Incidence in C3H/HeJ and C3H/OuJ.
JAX® NOTES, Spring 1995; 461. Neoplastic and Hyperplastic Lesions in the C3H/HeJ Mouse Strain.
JAX® NOTES, Spring 2003; 489. Malocclusion in the Laboratory Mouse.
JAX® NOTES, Spring 2005; 497. Update of Chromosome 6 Inversion in JAX® Mice Strain C3H/HeJ.
JAX® NOTES, Summer 2003; 490. Hydrocephalus in Laboratory Mice.
JAX® NOTES, Summer 2005; 498. Toll-like Receptor JAX® Mice for Immunological Research.
JAX® NOTES, Winter 2006; 504. JAX® Mice: the Gold Standard Just Got Better.
JAX® NOTES, Winter 2006; 504. Reliable New Sperm Cryopreservation Service Developed at The Jackson Laboratory.
Phenotype
Phenotype Information
Body Weight Information - JAX® Mice Strain C3H/HeJ (000659)Mouse Phenome Database
(This chart reflects the typical correlation between body weight and age for mice maintained in production colonies at The Jackson Laboratory.)
Mouse Phenome Database - body weight
Mouse Phenome Database - cardiovascular
Mouse Phenome Database - disease susceptibility
Mouse Phenome Database - ethanol effects
Mouse Phenome Database - food and water intake
Mouse Phenome Database - hematology
Mouse Phenome Database - lungs
Mouse Phenome Database / SNP Facility
Festing Inbred Strain Characteristics: C3H
JAX® Physiological Data Summary [pdf]
JAX® Physiological Data Protocol [pdf]
assigned by genotype
Ahrb-2/Ahrb-2
C3H/He
- life span-post-weaning/aging
- increased sensitivity to xenobiotic induced morbidity/mortality (MGI Ref ID J:26440)
- mice are susceptible to DMBA induced lethality
- homeostasis/metabolism phenotype
- increased physiological sensitivity to xenobiotics (MGI Ref ID J:26440)
- mice are susceptible to the pathological effects of DMBA and exhibit lethality, weight loss, peritonitis, decreased spleen weight, and decreased thymus weight
- increased sensitivity to xenobiotic induced morbidity/mortality (MGI Ref ID J:26440)
- mice are susceptible to DMBA induced lethality
This mouse can be used to support research in many areas including:
Pde6brd1 relatedCancer Research
Increased Tumor Incidence
Hepatomas
Mammary Gland Tumors: late onset
Cardiovascular Research
Diet-Induced Atherosclerosis
Relatively Resistant
Immunology and Inflammation Research
Immunodeficiency
Tlr deficiency
Neurobiology Research
Epilepsy
Research Tools
General Purpose
Sensorineural Research
Retinal Degeneration
Homozygous for Pde6brd1
Tlr4Lps-d relatedMouse/Human Gene Homologs
retinitis pigmentosa, autosomal recessive
Sensorineural Research
Retinal Degeneration
Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Tlr deficiency
Immunodeficiency
Tlr deficiency
Inflammation
Tlr deficiency
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Ahrb-2 | ||
|---|---|---|---|
| Allele Name | b-2 variant | ||
| Allele Type | Not Applicable | ||
| Common Name(s) | Ahb-2; Ahh; | ||
| Strain of Origin | BALB/cBy | ||
| Gene Symbol and Name | Ahr, aryl-hydrocarbon receptor | ||
| Chromosome | 12 | ||
| Gene Common Name(s) | Ah; Ahh; Ahre; In; aromatic hydrocarbon responsiveness; aryl hydrocarbon hydroxylase; bHLHe76; dioxin receptor; inflammatory reactivity; | ||
| General Note |
C57BL/6 carries the responsive Ahrb allele; DBA/2 carries nonresponsive Ahrd. Heterozygotes (Ahrb/Ahrd) are responsive (J:5282). Later work identified a second (J:8895) and later a third (J:22144) allele conferring response. Thus the allele in C57, C58, and MA/My strains is now Ahrb-1; Ahrb-2 is carried by BALB/cBy, A, and C3H; and Ahrb-3 by Mus spretus, M. caroli, and MOLF/Ei. The nonresponsive strains AKR, DBA/2, and 129 carry Ahrd (J:22144). Nucleotide and amino acid sequence differences between Ahrb-1 and Ahrd have been determined (J:17460). Strain of origin - this allele was found in BALB/cByJ, A/J, C3H/HeJ, CBA strains | ||
| Molecular Note | This allele encodes a high affinity, heat labile, 104 kDa receptor containing 848 amino acids. Sequencing studies of cDNA from C57BL/6J congenic mice homozygous for this allele identified nucleotide substitutions in the ORF that would cause 5 amino acid differences between the C57BL/6J and BALB/cBy peptides, and 2 amino acid differences between the BALB/cBy and DBA/2J peptides. A T to C transition in exon 11 replaces the opal termination codon in the C57BL/6J allele with an arginine codon in the BALB/cByallele. This change would extend translation of the BALB/cBy mRNA by 43 amino acids, accounting for the larger size of the peptide produced by this allele (104 kDa, vs 95 kDa for the C57BL/6J allele). [MGI Ref ID J:15153] [MGI Ref ID J:22144] | ||
| Allele Symbol | Gria4spkw1 | ||
| Allele Name | spike wave discharge 1 | ||
| Allele Type | QTL | ||
| Strain of Origin | C3H/HeJ | ||
| Gene Symbol and Name | Gria4, glutamate receptor, ionotropic, AMPA4 (alpha 4) | ||
| Chromosome | 9 | ||
| Gene Common Name(s) | GLUR4; GLUR4C; GLURD; GluR-D; Glur-4; Glur4; Gluralpha4; glutamate receptor 4; spike wave 1; spkw1; | ||
| General Note | This allele interacts with spkw2. Animals with the highest incidence of spike wave discharges are homozygous for C3H/HeJ-derived alleles at spkw1 and heterozygous for C57BL/6J and C3H/HeJ alleles at spkw2. | ||
| Molecular Note | Genomic PCR and sequencing showed a full-length intracisternal A-particle (IAP) proviral insertion in the last intron of Gria4 in C3H/HeJ mice. qRT-PCR showed a 10-fold difference in C3H/HeJ and C3HeB/FeJ substrains in transcripts detected between exons flanking the IAP-containing intron, and a neglible difference between upstream exon transcript levels in these substrains. Gria4 protein levels in HeJ cerebella are reduced compared with controls. [MGI Ref ID J:135814] | ||
| Allele Symbol | In(6)1J | ||
| Allele Name | inversion, Chr 6, Jackson 1 | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | C3H/HeJ | ||
| Gene Symbol and Name | In(6)1J, inversion, Chr 6, Jackson 1 | ||
| Chromosome | 6 | ||
| General Note | C3H/HeJ and C3H/HeJBir carry this inversion; C3H/HeSnJ and C3HeB/FeJ do not. Examination of recombination distances in Recombinant Inbred (RI) strain sets developed using C3H/HeJ as a progenitor suggest none of these harbor the inversion. Mouse strains carrying spontaneous mutations that arose on the C3H/HeJ background after 1965-1970 could carry the inversion and are expected to if the mutation arose after the early 1970s. | ||
| Molecular Note | The In(6)1J inversion covers approximately 20% of Chr 6 in C3H/HeJ mice. Therefore, linkage crosses using C3H/HeJ will show no recombination in this region of Chr 6. Genetic analyses of congenic construction crosses suggested that the suppressed region lies between D6Mit124 (cytological band 6C3) and D6Mit150 (cytological band 6F1). FISH analyses using flanking BACs detected a paracentric chromosomal region between ~73 Mb and ~116 Mb. [MGI Ref ID J:105810] [MGI Ref ID J:87486] | ||
| Allele Symbol | Pde6brd1 | ||
| Allele Name | retinal degeneration 1 | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | Pdebrd1; rd; rd-1; rd1; rodless retina; | ||
| Gene Symbol and Name | Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide | ||
| Chromosome | 5 | ||
| Gene Common Name(s) | CSNB3; PDEB; Pdeb; RP40; nmf137; phosphodiesterase, cGMP, rod receptor, beta polypeptide; r; rd; rd-1; rd1; rd10; retinal degeneration; retinal degeneration 1; retinal degeneration 10; | ||
| General Note | CBA/J mice carry this allele. | ||
| Molecular Note | Two mutations have been identified in rd1 mice. A murine leukimia virus (Xmv-28) insertion in reverse orientation in intron 1 is found in all mouse strains with the rd1 phenotype. Further, a nonsense mutation (C to A transversion) in codon 347 that results in a truncation eliminating more than half of the predicted encoded protein, including the catalytic domain has also been identified in all rd1 strains of mice. A specific degradation of mutant transcript during or after pre-mRNA splicing is suggested. [MGI Ref ID J:11513] [MGI Ref ID J:4366] [MGI Ref ID J:51361] | ||
| Allele Symbol | Tlr4Lps-d | ||
| Allele Name | defective lipopolysaccharide response | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | TLR4-Mu; TLR4lps-def; Tlr4-; Tlr4d; TlrLps-d; lpsd; | ||
| Strain of Origin | C3H/HeJ | ||
| Gene Symbol and Name | Tlr4, toll-like receptor 4 | ||
| Chromosome | 4 | ||
| Gene Common Name(s) | ARMD10; CD284; Lps; RAS-like, family 2, locus 8; Rasl2-8; TOLL; hToll; lipopolysaccharide response; | ||
| General Note |
C3H/HeJ mice carry this allele. Various combinations of Lps-associated traits have been followed in crosses between C3H/HeJ and other C3H substrains, and the traits have in all cases segregated together (J:30692, J:5557, J:5593, J:5938). Some of the traits show dominance of the Tlr4lps-n allele; others, including Tlr4Lps-d, show codominance. Genbank ID for this allele: AF095353 | ||
| Molecular Note | This allele corresponds to a mutation in the third exon of the gene. A C to A substitution at nucleotide position 2342 results in an amino acid substitution that replaces proline with histidine at position 712. [MGI Ref ID J:51522] [MGI Ref ID J:53519] [MGI Ref ID J:57938] | ||
Genotyping
Genotyping Information
Inbred mouse strains are maintained through sibling (sister x brother) matings; no genotyping required.
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Akeson EC; Donahue LR; Beamer WG; Shultz KL; Ackert-Bicknell C; Rosen CJ; Corrigan J; Davisson MT. 2006. Chromosomal inversion discovered in C3H/HeJ mice. Genomics 87(2):311-3. [PubMed: 16309882] [MGI Ref ID J:105810]
Dragani TA; Manenti G; Gariboldi M; Degregorio L; Pierotti MA. 1995. Genetics of liver tumor susceptibility in mice. Toxicol Lett 82-3:613-619. [PubMed: 8597117] [MGI Ref ID J:31816]
Heston WE; Vlahakis G. 1971. Mammary tumors, plaques, and hyperplastic alveolar nodules in various combinations of mouse inbred strains and the different lines of the mammary tumor virus. Int J Cancer 7(1):141-8. [PubMed: 4322934] [MGI Ref ID J:24674]
Outzen HC; Corrow D; Shultz LD. 1985. Attenuation of exogenous murine mammary tumor virus virulence in the C3H/HeJ mouse substrain bearing the Lps mutation. J Natl Cancer Inst 75(5):917-23. [PubMed: 2997536] [MGI Ref ID J:24864]
Paigen B; Ishida BY; Verstuyft J; Winters RB; Albee D. 1990. Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice. Arteriosclerosis 10(2):316-23. [PubMed: 2317166] [MGI Ref ID J:22615]
Additional References
DiPetrillo K; Tsaih SW; Sheehan S; Johns C; Kelmenson P; Gavras H; Churchill GA; Paigen B. 2004. Genetic analysis of blood pressure in C3H/HeJ and SWR/J mice. Physiol Genomics 17(2):215-20. [PubMed: 14996992] [MGI Ref ID J:89267]
Ewart SL; Kuperman D; Schadt E; Tankersley C; Grupe A; Shubitowski DM; Peltz G; Wills-Karp M. 2000. Quantitative trait loci controlling allergen-induced airway hyperresponsiveness in inbred mice. Am J Respir Cell Mol Biol 23(4):537-45. [PubMed: 11017920] [MGI Ref ID J:66641]
Fortier AH; Slayter MV; Ziemba R; Meltzer MS; Nacy CA. 1991. Live vaccine strain of Francisella tularensis: infection and immunity in mice. Infect Immun 59(9):2922-8. [PubMed: 1879918] [MGI Ref ID J:27016]
McElwee KJ; Boggess D; King LE Jr; Sundberg JP. 1998. Experimental induction of alopecia areata-like hair loss in C3H/HeJ mice using full-thickness skin grafts. J Invest Dermatol 111(5):797-803. [PubMed: 9804341] [MGI Ref ID J:111520]
McElwee KJ; Boggess D; Miller J; King LE Jr; Sundberg JP. 1999. Spontaneous alopecia areata-like hair loss in one congenic and seven inbred laboratory mouse strains J Investig Dermatol Symp Proc 4(3):202-6. [PubMed: 10674366] [MGI Ref ID J:60482]
Moeller GR; Terry L; Snyderman R. 1978. The inflammatory response and resistance to endotoxin in mice. J Immunol 120(1):116-23. [PubMed: 627714] [MGI Ref ID J:5936]
Moy SS; Nadler JJ; Young NB; Perez A; Holloway LP; Barbaro RP; Barbaro JR; Wilson LM; Threadgill DW; Lauder JM; Magnuson TR; Crawley JN. 2007. Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains. Behav Brain Res 176(1):4-20. [PubMed: 16971002] [MGI Ref ID J:138682]
Roberts JE; Watters JW; Ballard JD; Dietrich WF. 1998. Ltx1, a mouse locus that influences the susceptibility of macrophages to cytolysis caused by intoxication with Bacillus anthracis lethal factor, maps to chromosome 11. Mol Microbiol 29(2):581-91. [PubMed: 9720874] [MGI Ref ID J:49726]
Siebenhaar F; Sharov AA; Peters EM; Sharova TY; Syska W; Mardaryev AN; Freyschmidt-Paul P; Sundberg JP; Maurer M; Botchkarev VA. 2007. Substance P as an immunomodulatory neuropeptide in a mouse model for autoimmune hair loss (alopecia areata). J Invest Dermatol 127(6):1489-97. [PubMed: 17273166] [MGI Ref ID J:122923]
Sultzer BM. 1968. Genetic control of leucocyte responses to endotoxin. Nature 219(160):1253-4. [PubMed: 4877918] [MGI Ref ID J:5087]
Sundberg JP; Boggess D; Silva KA; McElwee KJ; King LE; Li R; Churchill G; Cox GA. 2003. Major locus on mouse chromosome 17 and minor locus on chromosome 9 are linked with alopecia areata in C3H/HeJ mice. J Invest Dermatol 120(5):771-5. [PubMed: 12713579] [MGI Ref ID J:83350]
Sundberg JP; Cordy WR; King LE Jr. 1994. Alopecia areata in aging C3H/HeJ mice. J Invest Dermatol 102(6):847-56. [PubMed: 8006447] [MGI Ref ID J:18877]
Welkos SL; Keener TJ; Gibbs PH. 1986. Differences in susceptibility of inbred mice to Bacillus anthracis. Infect Immun 51(3):795-800. [PubMed: 3081444] [MGI Ref ID J:8197]
West DB; Boozer CN; Moody DL; Atkinson RL. 1992. Dietary obesity in nine inbred mouse strains. Am J Physiol 262(6 Pt 2):R1025-32. [PubMed: 1621856] [MGI Ref ID J:1348]
Xie C; Sharma R; Wang H; Zhou XJ; Mohan C. 2004. Strain distribution pattern of susceptibility to immune-mediated nephritis. J Immunol 172(8):5047-55. [PubMed: 15067087] [MGI Ref ID J:122988]
Ahrb-2 relatedGria4spkw1 relatedNebert DW; Considine N; Owens IS. 1973. Genetic expression of aryl hydrocarbon hydroxylase induction. VI. Control of other aromatic hydrocarbon-inducible mono-oxygenase activities at or near the same genetic locus. Arch Biochem Biophys 157(1):148-59. [PubMed: 4716952] [MGI Ref ID J:84313]
Nebert DW; Gielen JE. 1972. Genetic regulation of aryl hydrocarbon hydroxylase induction in the mouse. Fed Proc 31(4):1315-25. [PubMed: 4114109] [MGI Ref ID J:5282]
Nebert DW; Jensen NM; Shinozuka H; Kunz HW; Gill TJ 3d. 1982. The Ah phenotype. Survey of forty-eight rat strains and twenty inbred mouse strains. Genetics 100(1):79-87. [PubMed: 7095422] [MGI Ref ID J:6809]
Nebert DW; Robinson JR; Niwa A; Kumaki K; Poland AP. 1975. Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse. J Cell Physiol 85(2 Pt 2 Suppl 1):393-414. [PubMed: 1091656] [MGI Ref ID J:84317]
Niwa A; Kumaki K; Nebert DW; Poland AP. 1975. Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse. Distinction between the 'responsive' homozygote and heterozygote at the Ah locus. Arch Biochem Biophys 166(2):559-64. [PubMed: 1119809] [MGI Ref ID J:84316]
Poland A; Glover E. 1990. Characterization and strain distribution pattern of the murine Ah receptor specified by the Ahd and Ahb-3 alleles. Mol Pharmacol 38(3):306-12. [PubMed: 2169579] [MGI Ref ID J:34840]
Poland A; Glover E; Taylor BA. 1987. The murine Ah locus: a new allele and mapping to chromosome 12. Mol Pharmacol 32(4):471-8. [PubMed: 2823093] [MGI Ref ID J:8895]
Poland A; Palen D; Glover E. 1994. Analysis of the four alleles of the murine aryl hydrocarbon receptor. Mol Pharmacol 46(5):915-21. [PubMed: 7969080] [MGI Ref ID J:22144]
Robinson JR; Considine N; Nebert DW. 1974. Genetic expression of aryl hydrocarbon hydroxylase induction. Evidence for the involvement of other genetic loci. J Biol Chem 249(18):5851-9. [PubMed: 4413562] [MGI Ref ID J:84315]
Schmid FA; Pena RC; Robinson W; Tarnowski GS. 1967. Toxicity of intraperitoneal injections of 7, 12-dimethylbenz[a]anthracene in inbred mice. Cancer Res 27(3):558-62. [PubMed: 6021513] [MGI Ref ID J:26440]
Schmidt JV; Carver LA; Bradfield CA. 1993. Molecular characterization of the murine Ahr gene. Organization, promoter analysis, and chromosomal assignment. J Biol Chem 268(29):22203-9. [PubMed: 8408082] [MGI Ref ID J:15153]
Thomas PE; Hutton JJ; Taylor BA. 1973. Genetic relationship between aryl hydrocarbon hydroxylase inducibility and chemical carcinogen induced skin ulceration in mice. Genetics 74(4):655-9. [PubMed: 4750810] [MGI Ref ID J:5387]
Pde6brd1 relatedBeyer B; Deleuze C; Letts VA; Mahaffey CL; Boumil RM; Lew TA; Huguenard JR; Frankel WN. 2008. Absence seizures in C3H/HeJ and knockout mice caused by mutation of the AMPA receptor subunit Gria4. Hum Mol Genet 17(12):1738-49. [PubMed: 18316356] [MGI Ref ID J:135814]
Frankel WN; Beyer B; Maxwell CR; Pretel S; Letts VA; Siegel SJ. 2005. Development of a new genetic model for absence epilepsy: spike-wave seizures in C3H/He and backcross mice. J Neurosci 25(13):3452-8. [PubMed: 15800200] [MGI Ref ID J:98638]
Tlr4Lps-d relatedAcosta ML; Fletcher EL; Azizoglu S; Foster LE; Farber DB; Kalloniatis M. 2005. Early markers of retinal degeneration in rd/rd mice. Mol Vis 11:717-28. [PubMed: 16163270] [MGI Ref ID J:103970]
Aftab U; Jiang C; Tucker B; Kim JY; Klassen H; Miljan E; Sinden J; Young M. 2009. Growth kinetics and transplantation of human retinal progenitor cells. Exp Eye Res 89(3):301-10. [PubMed: 19524569] [MGI Ref ID J:151412]
Ahuja S; Ahuja-Jensen P; Johnson LE; Caffe AR; Abrahamson M; Ekstrom PA; van Veen T. 2008. rd1 Mouse retina shows an imbalance in the activity of cysteine protease cathepsins and their endogenous inhibitor cystatin C. Invest Ophthalmol Vis Sci 49(3):1089-96. [PubMed: 18326735] [MGI Ref ID J:133024]
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Yusuf N; Nasti TH; Long JA; Naseemuddin M; Lucas AP; Xu H; Elmets CA. 2008. Protective role of Toll-like receptor 4 during the initiation stage of cutaneous chemical carcinogenesis. Cancer Res 68(2):615-22. [PubMed: 18199559] [MGI Ref ID J:131415]
Zamboni DS; Campos MA; Torrecilhas AC; Kiss K; Samuel JE; Golenbock DT; Lauw FN; Roy CR; Almeida IC; Gazzinelli RT. 2004. Stimulation of toll-like receptor 2 by Coxiella burnetii is required for macrophage production of pro-inflammatory cytokines and resistance to infection. J Biol Chem 279(52):54405-15. [PubMed: 15485838] [MGI Ref ID J:95155]
Zanotti G; Casiraghi M; Abano JB; Tatreau JR; Sevala M; Berlin H; Smyth S; Funkhouser WK; Burridge K; Randell SH; Egan TM. 2009. Novel critical role of Toll-like receptor 4 in lung ischemia-reperfusion injury and edema. Am J Physiol Lung Cell Mol Physiol 297(1):L52-63. [PubMed: 19376887] [MGI Ref ID J:151006]
Zhang X; Shan P; Jiang G; Cohn L; Lee PJ. 2006. Toll-like receptor 4 deficiency causes pulmonary emphysema. J Clin Invest 116(11):3050-9. [PubMed: 17053835] [MGI Ref ID J:114985]
Zhang Y; Woodruff M; Zhang Y; Miao J; Hanley G; Stuart C; Zeng X; Prabhakar S; Moorman J; Zhao B; Yin D. 2008. Toll-like receptor 4 mediates chronic restraint stress-induced immune suppression. J Neuroimmunol 194(1-2):115-22. [PubMed: 18192029] [MGI Ref ID J:131903]
Zhou Q; Desta T; Fenton M; Graves DT; Amar S. 2005. Cytokine profiling of macrophages exposed to Porphyromonas gingivalis, its lipopolysaccharide, or its FimA protein. Infect Immun 73(2):935-43. [PubMed: 15664935] [MGI Ref ID J:95773]
van Rossum AM; Lysenko ES; Weiser JN. 2005. Host and bacterial factors contributing to the clearance of colonization by Streptococcus pneumoniae in a murine model. Infect Immun 73(11):7718-26. [PubMed: 16239576] [MGI Ref ID J:104292]
Akeson EC. 2003. Chromosomal inversion discovered in C3H/HeJ mice JAX Notes 491:15. [MGI Ref ID J:87486]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX10
Room Number AX3
Room Number AX4
Room Number RB03
Colony Maintenance
Mating System Sibling x Sibling (Female x Male) 01-MAR-06 Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
|
Weeks of Age Price (US dollars $) Gender 3 weeks $18.40 Female $16.45 Male 4 weeks $18.40 Female $16.45 Male 5 weeks $18.40 Female $16.45 Male 6 weeks $20.40 Female $18.45 Male 7 weeks $22.40 Female $20.45 Male 8 weeks $24.40 Female $22.45 Male 9 weeks $24.80 Female $23.45 Male 10 weeks $28.70 Female $27.30 Male 11 weeks $28.70 Female $27.30 Male 12 weeks $28.70 Female $27.30 Male 13 weeks $30.75 Female $29.35 Male 14 weeks $32.80 Female $31.40 Male 15 weeks $34.85 Female $33.45 Male JAX® Cells, Tissues & Products
JAX® mES Cells
Item Number Product Name Price/Vial (US dollars $) 000659E01 C3H/HeJ-PB151.24 mES cells $1500.00
Additional Supply Details
| Supply Notes |
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| Pricing for International shipping destinations |
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Weeks of Age Price (US dollars $) Gender 3 weeks $24.00 Female $21.40 Male 4 weeks $24.00 Female $21.40 Male 5 weeks $24.00 Female $21.40 Male 6 weeks $26.60 Female $24.00 Male 7 weeks $29.20 Female $26.60 Male 8 weeks $31.80 Female $29.20 Male 9 weeks $32.30 Female $30.50 Male 10 weeks $37.40 Female $35.50 Male 11 weeks $37.40 Female $35.50 Male 12 weeks $37.40 Female $35.50 Male 13 weeks $40.00 Female $38.20 Male 14 weeks $42.70 Female $40.90 Male 15 weeks $45.40 Female $43.50 Male JAX® Cells, Tissues & Products
JAX® mES Cells
Item Number Product Name Price/Vial (US dollars $) 000659E01 C3H/HeJ-PB151.24 mES cells $1500.00
Additional Supply Details
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Supply Details
| Standard Supply | JAX Ready Strain®. Most popular strains. Readily available in any quantity you need. |
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| Supply Notes |
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| Important Note | |
| This strain does not carry mouse mammary tumor virus (MMTV). See JAX® NOTES, May 2000, No. 480. This strain is homozygous for retinal degeneration allele Pde6brd1, the defective lipopolysaccharide response allele Tlr4Lps-d, and for a chromosomal inversion on Chromosome 6. | |
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The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
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In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. In purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.