Strain Name:

C57BL/6J

Stock Number:

000664

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Availability:

Level 1

Common Names: C57 Black;     B6;     B6J;     Black 6;    
C57BL/6J is the most widely used inbred strain and the first to have its genome sequenced. Although this strain is refractory to many tumors, it is a permissive background for maximal expression of most mutations. C57BL/6J mice are resistant to audiogenic seizures, have a relatively low bone density, and develop age related hearing loss. They are also susceptible to diet-induced obesity, type 2 diabetes, and atherosclerosis. Macrophages from this strain are resistant to the effects of anthrax lethal toxin.

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Description

Strain Information

Type Spontaneous Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Type Inbred Strain;
Additional information on Inbred Strains.
Visit our online Nomenclature tutorial.
Mating SystemSibling x Sibling         (Female x Male)   01-MAR-06
Breeding Considerations This strain is a good breeder.
Specieslaboratory mouse
H2 Haplotypeb
GenerationF226PF235 (17-SEP-12)
Generation Definitions

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Appearance
black
Related Genotype: a/a

Important Note
This strain is homozygous for Cdh23ahl, the age related hearing loss 1 mutation, which on this background results in progressive hearing loss with onset after 10 months of age.

Description
C57BL/6 is the most widely used inbred strain. It is commonly used as a general purpose strain and background strain for the generation of congenics carrying both spontaneous and induced mutations. Although this strain is refractory to many tumors, it is a permissive background for maximal expression of most mutations. C57BL/6J mice are used in a wide variety of research areas including cardiovascular biology, developmental biology, diabetes and obesity, genetics, immunology, neurobiology, and sensorineural research. C57BL/6J mice are also commonly used in the production of transgenic mice. Overall, C57BL/6 mice breed well, are long-lived, and have a low susceptibility to tumors. Primitive hematopoietic stem cells from C57BL/6J mice show greatly delayed senescence relative to BALB/c and DBA/2J. This is a dominant trait. Other characteristics include: 1) a high susceptibility to diet-induced obesity, type 2 diabetes, and atherosclerosis; 2) a high incidence of microphthalmia and other associated eye abnormalities; 3) resistance to audiogenic seizures; 4) low bone density; 5) hereditary hydrocephalus (early reports indicate 1 - 4 %); 6) hairloss associated with overgrooming, 7) a preference for alcohol and morphine; 8) late-onset hearing loss; and 9) increased incidence of hydrocephalus and malocclusion.

C57BL/6J mice fed a high-fat diet develop obesity, mild to moderate hyperglycemia, and hyperinsulinemia (see JAX® Diet-induced Obesity (DIO) Models). C57BL/6J mice fed an atherogenic diet (1.25% cholesterol, 0.5% cholic acid and 15% fat) for 14 weeks develop lesions in the range of 4500 to 8000 um2 atherosclerotic aortic lesions/aortic cross-section. The variation in aortic lesions found among various inbred strains has led to the identification of the existence of eight genes affecting atherosclerosis, Ath1 to Ath8. C57BL/6J mice also develop severe and progressive hearing loss later in life. Histopathological changes associated with age-related hearing loss include the disruption of both outer and inner hair cells. C57BL/6 mice are also more susceptible to noise-induced hearing loss. Age related hearing loss 1 (Ahl), a major gene responsible for this hearing loss, was mapped in an intersubspecific backcross by measuring elevated auditory-evoked brainstem response (ABR) thresholds. Ahl is located on Chromosome 10 near marker D10Mit5. A naturally occurring deletion in nicotinamide nucleotide transhydrogenase (Nnt) exons 7-11 occurred in C57BL/6J sometime prior to 1984. This deletion results in the absence of the NNT protein, and is associated with impaired glucose homeostasis control and reduced insulin secretion. This mutation is not found in C57BL/6JEi, C57BL/6N, C57BL/6NJ, C57BL/6ByJ, C57BL/10J, C57L/J, or C58/J (Toye AA, et al, Diabetologia, 2005). Since C57BL/6JEi separated from C57BL/6J in 1976, the Nnt deletion arose sometime between 1976 and 1984.

C57BL/6J was the DNA source for the international collaboration that generated the first high quality draft sequence of the mouse genome. 5 SNP differences have been identified that distinguish C57BL/6J from C57BL/6ByJ and C57BL/6NJ. Both C57BL/6ByJ and C57BL/6NJ type as follows: 08-015199792-M (rs3709624) is C; 11-004367508-M (rs3659787) is A; 13-041017317-M (rs3722313) is C; 15-057561875-M (rs3702158) is G; 19-049914266-M (rs3724876) is T. C57BL/6J types as follows: 08-015199792-M (rs3709624) is T; 11-004367508-M (rs3659787) is G; 13-041017317-M (rs3722313) is T; 15-057561875-M (rs3702158) is A; 19-049914266-M (rs3724876) is G (Petkov and Wiles, 2004.) Others have subsequently identified further SNP differences between sublines of C57BL/6 (Mekada et al., 2009, Zurita et al., 2010).

Development
The C57BL/6J inbred strain was created by Dr. CC Little from the mating of female 57 with male 52 from Miss Abbie Lathrop's stock. The same cross gave rise to the C57L and C57BR strains.

Related Strains

C57BL Strains
000665   C57BL/10J
003752   C57BL/10ScNJ
000476   C57BL/10ScSnJ
000666   C57BL/10SnJ
001822   C57BL/10SxJ
001197   C57BL/10WtRkJ
000663   C57BL/6By
001139   C57BL/6ByJ
009123   C57BL/6HaJ
000924   C57BL/6JEiJ
005304   C57BL/6NJ
View C57BL Strains     (11 strains)

Strains carrying   Ahrb-1 allele
000136   B6.C-H34c/(HW22)ByJ
000663   C57BL/6By
001139   C57BL/6ByJ
000662   C57BLKS/J
000667   C57BR/cdJ
000668   C57L/J
000669   C58/J
000351   CXB1/ByJ
000356   CXB6/ByJ
002937   D2.B6-Ahrb-1/J
000677   MA/MyJ
View Strains carrying   Ahrb-1     (11 strains)

Strains carrying   Cdh23ahl allele
001137   129P1/ReJ
000690   129P3/J
000691   129X1/SvJ
000646   A/J
000647   A/WySnJ
003070   ALR/LtJ
003072   ALS/LtJ
004502   B6;AKR-Lxl2/GrsrJ
001026   BALB/cByJ
000653   BUB/BnJ
005494   C3.129S1(B6)-Grm1rcw/J
004764   C57BL/6J-Cdh23v-8J/J
003129   C57BL/6J-Epha4rb-2J/GrsrJ
004820   C57BL/6J-Kcne12J/J
004703   C57BL/6J-Kcnq2Nmf134/J
004811   C57BL/6J-nmf110/J
004812   C57BL/6J-nmf111/J
004747   C57BL/6J-nmf118/J
004656   C57BL/6J-nmf88/J
004391   C57BL/6J-Chr 13A/J/NaJ
004385   C57BL/6J-Chr 7A/J/NaJ
000662   C57BLKS/J
000667   C57BR/cdJ
000668   C57L/J
000669   C58/J
010614   CBACa.B6-Cdh23ahl/Kjn
000657   CE/J
000670   DBA/1J
001140   DBA/1LacJ
000671   DBA/2J
007048   DBA/2J-Gpnmb+/SjJ
002106   KK/HlJ
000675   LG/J
000676   LP/J
000677   MA/MyJ
001976   NOD/ShiLtJ
002050   NOR/LtJ
000679   P/J
002747   SENCARB/PtJ
002335   SKH2/J
003392   STOCK Crb1rd8/J
View Strains carrying   Cdh23ahl     (41 strains)

Strains carrying   Micrln allele
000646   A/J
000651   BALB/cJ
000009   BXH14/TyJ
000038   BXH6/TyJ
000014   BXH7/TyJ
000665   C57BL/10J
000669   C58/J
View Strains carrying   Micrln     (7 strains)

Strains carrying   P2rx7P451L allele
000665   C57BL/10J
000670   DBA/1J
000671   DBA/2J
View Strains carrying   P2rx7P451L     (3 strains)

Strains carrying other alleles of Ahr
000690   129P3/J
000645   A/HeJ
000646   A/J
000648   AKR/J
002920   B6(D2N).Spretus-Ahrb-3/J
002831   B6.129-Ahrtm1Bra/J
000130   B6.C-H17c/(HW14)ByJ
000370   B6.C-H38c/(HW119)ByJ
008599   B6.Cg-Cyp1a2/Cyp1a1tm2Dwn Ahrd Tg(CYP1A1,CYP1A2)1Dwn/DwnJ
002921   B6.D2N-Ahrd/J
002727   B6;129-Ahrtm1Bra/J
001026   BALB/cByJ
000652   BDP/J
000653   BUB/BnJ
000659   C3H/HeJ
000926   CAROLI/EiJ
000928   CAST/EiJ
000656   CBA/J
000657   CE/J
000352   CXB2/ByJ
000353   CXB3/ByJ
000354   CXB4/ByJ
000355   CXB5/ByJ
000357   CXB7/ByJ
000671   DBA/2J
000673   HRS/J
000674   I/LnJ
000675   LG/J
000676   LP/J
000550   MOLF/EiJ
000684   NZB/BlNJ
000679   P/J
000930   PERA/EiJ
000726   RBF/DnJ
000682   RF/J
000644   SEA/GnJ
000280   SF/CamEiJ
000686   SJL/J
001146   SPRET/EiJ
000688   ST/bJ
006203   STOCK Ahrtm3.1Bra/J
000689   SWR/J
000693   WC/ReJ KitlSl/J
000933   YBR/EiJ
View Strains carrying other alleles of Ahr     (44 strains)

Strains carrying other alleles of Cdh23
002552   B6(V)-Cdh23v-2J/J
002756   B6.CAST-Cdh23Ahl+/Kjn
010615   B6.CBACa-Cdh23CBA/CaJ/Kjn
002432   B6J x B6.C-H2-Kbm1/ByJ-Cdh23v-J/J
004764   C57BL/6J-Cdh23v-8J/J
004819   C57BL/6J-Cdh23v-9J/J
005016   CByJ;B6-Cdh23v-10J/J
000275   V/LeJ
View Strains carrying other alleles of Cdh23     (8 strains)

Strains carrying other alleles of Fbrwt1
000671   DBA/2J
View Strains carrying other alleles of Fbrwt1     (1 strain)

Strains carrying other alleles of Fbrwt2
000671   DBA/2J
View Strains carrying other alleles of Fbrwt2     (1 strain)

Strains carrying other alleles of Micrl
000032   BXH10/TyJ
000033   BXH19/TyJ
000011   BXH4/TyJ
000076   BXH8/TyJ
000008   BXH9/TyJ
000260   JGBF/LeJ
000072   JGBF/LeTyJ
View Strains carrying other alleles of Micrl     (7 strains)

Strains carrying other alleles of P2rx7
005576   B6.129P2-P2rx7tm1Gab/J
015809   NOD.129P2(B6)-P2rx7tm1Gab/DvsJ
View Strains carrying other alleles of P2rx7     (2 strains)

Additional Web Information

3D MRI Digital Atlas Database of Adult C57BL/6J Mouse Brain
JAX® NOTES, April 1988; 433. H-2 Haplotypes of Mice from Jackson Laboratory Production Colonies.
JAX® NOTES, Fall 1995; 463. Inbred C57 Black Mice: Microphthalmia and Ocular Infections.
JAX® NOTES, Fall 2003; 491. The Importance of Understanding Substrains in the Genomic Age.
JAX® NOTES, Fall 2006; 503. Cause of Glucose Intolerance in C57BL/6J Mice Discovered.
JAX® NOTES, Fall 2008; 511. Influence of Nnt alleles on DIO in C57BL/6 JAX® Mice.
JAX® NOTES, January 1988; 432. Arthritis Models in the Mouse.
JAX® NOTES, July 1989; 438. Profile: C57BL/6J.
JAX® NOTES, October 1987; 431. Alopecia (loss of hair) in C57BL/6J and Related Strains.
JAX® NOTES, October 1989; 439. Splenic Melanosis in Black Mice.
JAX® NOTES, Spring 1990; 441. Imperforate Vagina and Mucometra in Mice.
JAX® NOTES, Spring 2003; 489. Malocclusion in the Laboratory Mouse.
JAX® NOTES, Spring 2003; 489. Mouse Genome Sequence Released.
JAX® NOTES, Spring 2004; 493. Chromosome Substitution Strain Panel: A New Tool for Quantitative Trait Loci Analysis.
JAX® NOTES, Spring 2007; 505. C57BL/6J Strain Used to Construct the Allen Brain Atlas.
JAX® NOTES, Spring 2009; 513. JAX® Mice help reveal potential health benefits of resveratrol.
JAX® NOTES, Summer 1994; 458. Ly5 Gene Nomenclature, C57BL/6J and SJL/J - A History of Change.
JAX® NOTES, Summer 2003; 490. Charles River Japan Now Breeding JAX® Mice Strain C57BL/6J.
JAX® NOTES, Summer 2003; 490. Hydrocephalus in Laboratory Mice.
JAX® NOTES, Summer 2006; 502. Characterization of DIO Model is Refined.
JAX® NOTES, Summer 2009; 514. JAX® Mice Study: Starvation Diet Does Not Extend Life.
JAX® NOTES, Summer 2009; 514. Another Obesity-modulating Gene Revealed.
JAX® NOTES, Summer 2009; 514. Defective Gene Plays Unexpected Role in Fat Metabolism.
JAX® NOTES, Summer 2009; 514. Non-Invasive Technique - Potential Parkinson's Therapy.
JAX® NOTES, Winter 2002; 488. Colony Expansions Completed for JAX® Mice Strains C57BL/6J and BALB/cJ.
JAX® NOTES, Winter 2006; 504. JAX® Mice: the Gold Standard Just Got Better.
JAX® NOTES, Winter 2008; 512. New resource illustrates divergence of C57BL/6 laboratory mouse substrains.
Mouse Phenome Database / SNP Facility
National Center for Biotechnology Information / SNP Data
Request a copy of our Divergence of C57BL/6 Laboratory Mouse poster.

Phenotype

Phenotype Information

View Phenotypic Data

Phenotypic Data

Body Weight Information - JAX® Mice Strain C57BL/6J (000664)

(This chart reflects the typical correlation between body weight and age for mice maintained in production colonies at The Jackson Laboratory.)
Mouse Phenome Database
Festing Inbred Strain Characteristics: C57BL
JAX® Physiological Data Summary [pdf]
JAX® Physiological Data Protocol [pdf]
View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Deafness, Autosomal Recessive 12; DFNB12   (CDH23)
Glucocorticoid Deficiency 4; GCCD4   (NNT)
Usher Syndrome, Type ID; USH1D   (CDH23)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

       
  • cardiovascular system phenotype
  • decreased cardiac muscle contractility
    • average left ventricular shortening of 39.1 is significantly lower than the 47.1 in A/J mice   (MGI Ref ID J:76471)
    • aortic ejection time is significantly longer than in A/J mice   (MGI Ref ID J:76471)
  • decreased heart rate
    • average 433 beats per minute versus 524 in A/J   (MGI Ref ID J:76471)
  • increased heart rate
    • average heart rate is approximately 50 beats per minute higher than that in A/J   (MGI Ref ID J:76471)
  • increased left ventricle weight
    • average left ventricular weight of 46.2mg is significantly higher than control A/J and results from an increase in the end-diastolic dimension and a proportional increase in wall thickness   (MGI Ref ID J:76471)
  • muscle phenotype
  • decreased cardiac muscle contractility
    • average left ventricular shortening of 39.1 is significantly lower than the 47.1 in A/J mice   (MGI Ref ID J:76471)
    • aortic ejection time is significantly longer than in A/J mice   (MGI Ref ID J:76471)
  • homeostasis/metabolism phenotype
  • enhanced exercise endurance
    • exercise time on a treadmill is significantly greater than that of A/J   (MGI Ref ID J:76471)

Ahrb-1/Ahrb-1

        C57BL/6J
  • mortality/aging
  • increased sensitivity to xenobiotic induced morbidity/mortality
    • mice are susceptible to DMBA induced lethality   (MGI Ref ID J:26440)
  • homeostasis/metabolism phenotype
  • *normal* homeostasis/metabolism phenotype
    • topical application of the polycyclic hydrocarbon DMBA induced hepatic aryl hydrocarbon hydroxylase activity   (MGI Ref ID J:5387)
    • increased physiological sensitivity to xenobiotic
      • mice are susepctible to the teratogenic effects of TCDD with 100% of mice developing cleft palates and 90% of mice developing severe hydronephrosis   (MGI Ref ID J:132380)
      • mice are susceptible to the pathological effects of DMBA and exhibit lethality, weight loss, peritonitis, decreased spleen weight, and decreased thymus weight   (MGI Ref ID J:26440)
      • mice exposed to DMBA exhibit decreased lymphocyte counts, increased polymorphic cells, decreased bone marrow cell counts and ascites formation   (MGI Ref ID J:26440)
    • increased sensitivity to xenobiotic induced morbidity/mortality
      • mice are susceptible to DMBA induced lethality   (MGI Ref ID J:26440)
  • immune system phenotype
  • increased inflammatory response
    • topical application of the polycyclic hydrocarbon DMBA produced skin inflammation and ulceration   (MGI Ref ID J:5244)
    • topical application of DMBA produced skin inflammation and ulceration   (MGI Ref ID J:5387)

Ahrb-1/Ahrb-1

        C57BL/6
  • mortality/aging
  • increased sensitivity to xenobiotic induced morbidity/mortality
    • mice exhibit neonatal lethality in response to in utero exposure to cHBB unlike mice homozygous for the Ahrd allele   (MGI Ref ID J:113285)
  • homeostasis/metabolism phenotype
  • increased physiological sensitivity to xenobiotic
    • when mice are fostered by control C57BL/6 dams following in utero exposure to cHBB, 21% of neonates survive   (MGI Ref ID J:113285)
    • mice exhibit neonatal lethality in response to in utero exposure to cHBB and decreased thymus and spleen weights compared to untreated mice   (MGI Ref ID J:113285)
    • following exposure to cHBB in utero, neonates exhibit an increase in volume density of hematopoietic islands in the liver   (MGI Ref ID J:113285)
  • increased sensitivity to xenobiotic induced morbidity/mortality
    • mice exhibit neonatal lethality in response to in utero exposure to cHBB unlike mice homozygous for the Ahrd allele   (MGI Ref ID J:113285)

Cdh23ahl/Cdh23ahl

        C57BL/6J
  • hearing/vestibular/ear phenotype
  • organ of Corti degeneration
    • in 3 of 4 cochleae assesed at 12 months of age the organ of Corti had totally degenerated   (MGI Ref ID J:87783)
  • nervous system phenotype
  • cochlear ganglion hypoplasia
    • at 9 months of age there is a decrease in the ganglion cell density for each turn over time with the largest cell loss in the basal turn   (MGI Ref ID J:87783)

Gluchos1C57BL/6J/Gluchos1C57BL/6J

        C57BL/6J
  • endocrine/exocrine gland phenotype
  • decreased insulin secretion
    • this phenotype is rescued by transgenic expression of full-length Nnt sequence derived from 129S6/SvEvTac   (MGI Ref ID J:109356)
  • homeostasis/metabolism phenotype
  • decreased insulin secretion
    • this phenotype is rescued by transgenic expression of full-length Nnt sequence derived from 129S6/SvEvTac   (MGI Ref ID J:109356)
  • impaired glucose tolerance
    • this phenotype is rescued by transgenic expression of full-length Nnt sequence derived from 129S6/SvEvTac   (MGI Ref ID J:109356)

Myo5ad/Myo5ad

        involves: C57BL/6J
  • pigmentation phenotype
  • abnormal melanocyte morphology
    • cultured primary melanocytes display clustering of melanosomes but are otherwise normal   (MGI Ref ID J:37976)

NntC57BL/6J/NntC57BL/6J

        C57BL/6J
  • endocrine/exocrine gland phenotype
  • decreased insulin secretion
    • this phenotype is rescued by transgenic expression of full-length Nnt sequence derived from 129S6/SvEvTac   (MGI Ref ID J:109356)
  • homeostasis/metabolism phenotype
  • decreased insulin secretion
    • this phenotype is rescued by transgenic expression of full-length Nnt sequence derived from 129S6/SvEvTac   (MGI Ref ID J:109356)
  • impaired glucose tolerance
    • this phenotype is rescued by transgenic expression of full-length Nnt sequence derived from 129S6/SvEvTac   (MGI Ref ID J:109356)

P2rx7P451L/P2rx7P451L

        C57BL/6
  • cellular phenotype
  • abnormal cell death
    • lysis triggered by extracellular ATP is reduced 45% in C57BL/6 mice as compared to BALB/c   (MGI Ref ID J:89513)
    • abnormal apoptosis
      • sensitivity to extracellular ATP induced apoptosis is reduced in C57BL/6 relative to BALB/c   (MGI Ref ID J:89513)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Cardiovascular Research
Diet-Induced Atherosclerosis
      Susceptible

Developmental Biology Research
Eye Defects
Lymphoid Tissue Defects
      hematopoietic defects
Skeletal Defects

Diabetes and Obesity Research
Hyperglycemia
      diet-induced, moderate
Hyperinsulinemia
      diet-induced
Insulin Resistance
      diet-induced
Obesity With Diabetes
      diet-induced, moderate
Type 2 Diabetes (NIDDM)
      diet-induced

Hematological Research
Hematopoietic Defects

Immunology, Inflammation and Autoimmunity Research
Lymphoid Tissue Defects
      hematopoietic development

Neurobiology Research
Behavioral and Learning Defects
Hearing Defects
      Age related hearing loss

Research Tools
General Purpose
Genetics Research
      Mutagenesis and Transgenesis
      Mutagenesis and Transgenesis: Production of Transgenic Mice
Hematological Research
Immunology, Inflammation and Autoimmunity Research
      background strain for histocompatibility congenics
Infectious Disease
      Salmonella
      Tuberculosis (TB)

Sensorineural Research
Eye Defects
Hearing Defects
      Age related hearing loss

Ahrb-1 related

Metabolism Research

Research Tools
Toxicology Research

Cdh23ahl related

Neurobiology Research
Hearing Defects
      Age related hearing loss

Sensorineural Research
Hearing Defects
      Age related hearing loss

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Ahrb-1
Allele Name b-1 variant
Allele Type Not Applicable
Common Name(s) Ah; Ahb-1; Ahb; Ahhi; Ahrb; In;
Strain of OriginC57BL/6J
Gene Symbol and Name Ahr, aryl-hydrocarbon receptor
Chromosome 12
Gene Common Name(s) Ah; Ahh; Ahre; In; aromatic hydrocarbon responsiveness; aryl hydrocarbon hydroxylase; bHLHe76; dioxin receptor; inflammatory reactivity;
General Note C57BL/6 carries the responsive Ahrb allele; DBA/2 carries nonresponsive Ahrd. Heterozygotes (Ahrb/Ahrd) are responsive (J:5282). Later work identified a second (J:8895) and later a third (J:22144) allele conferring response. Thus the allele in C57, C58, and MA/My strains is now Ahrb-1; Ahrb-2 is carried by BALB/cBy, A, and C3H; and Ahrb-3 by Mus spretus, M. caroli, and MOLF/Ei. The nonresponsive strains AKR, DBA/2, and 129 carry Ahrd (J:22144). Nucleotide and amino acid sequence differences between Ahrb-1 and Ahrd have been determined (J:17460).

Strain of origin - this allele was found in C57BL/6, C58/J, C57BR, MA/My strains

Molecular Note This allele encodes a high affinity, relatively heat stabile, 95 kDa receptor. PCR sequencing of cDNA revealed ten nucleotide differences between the coding sequences of the DBA/2J and C57BL/6J receptors. Five of the ten differences would cause amino acid changes. One of these, a C to T transition in exon 11 would change the arginine codon in the DBA/2J allele to an opal termination codon in the C57BL/6J allele. This change would prevent the 43 amino acid extension of mRNA translation predicted for the DBA/2J allele and account for the smaller size of the peptide produced by this allele (95 kDa vs 104 kDa for the DBA/2J allele). A second C to T transition changes a proline codon in the DBA/2J allele to leucine codon in the C57BL/6J allele, and would likely change secondary structure of the peptide and thus ligand affinity. [MGI Ref ID J:15153] [MGI Ref ID J:17460] [MGI Ref ID J:477]
 
Allele Symbol Cdh23ahl
Allele Name age related hearing loss 1
Allele Type QTL
Common Name(s) Cdh23753A; mdfw;
Strain of Originmultiple strains
Gene Symbol and Name Cdh23, cadherin 23 (otocadherin)
Chromosome 10
Gene Common Name(s) 4930542A03Rik; CDHR23; RIKEN cDNA 4930542A03 gene; USH1D; W; age related hearing loss 1; ahl; bob; bobby; bus; bustling; mdfw; modifier of deaf waddler; neuroscience mutagenesis facility, 112; neuroscience mutagenesis facility, 181; neuroscience mutagenesis facility, 252; nmf112; nmf181; nmf252; sals; salsa; v; waltzer;
Molecular Note Genetic complementation tests have shown allelism between the mdfw (modifier of deaf waddler) locus and the ahl locus. Further analysis has identified an association between ahl and a G to A transition at nucleotide position 753 of Cdh23. This hypomorphic allele causes in frame skipping of exon 7 and reduced message stability. Twenty-seven strains classified with ahl and carrying the 753A allele include: CD1, RBF/DnJ, PL/J, AKR/J, RF/J, BALB/cBy, A/WySnJ, P/J, SENCARA/PtJ, DBA/1J, ALS/LtJ, C58/J, C57BLKS/J, 129P1/ReJ, C57BR/cd, SKH2/J, BUB/Bn, MA/MyJ, LP/J, 129X1/SvJ, NOR/LtJ, A/J, C57BL/6, NOD/LtJ, DBA/2J, ALR/LtJ, C57L/J. Strains classified with ahl that DO NOT carry this mutation include: C3H/HeSnJ, I/LnJ,YBR/Ei, MRL/MpJ. [MGI Ref ID J:86905]
 
Allele Symbol Fbrwt1C57BL/6J
Allele Name C57BL/6J
Allele Type QTL
Strain of OriginC57BL/6J
Gene Symbol and Name Fbrwt1, forebrain weight 1
Chromosome 1
Molecular Note This allele confers increased forebrain weight compared to DBA/2J. [MGI Ref ID J:143361]
 
Allele Symbol Fbrwt2C57BL/6J
Allele Name C57BL/6J
Allele Type QTL
Strain of OriginC57BL/6J
Gene Symbol and Name Fbrwt2, forebrain weight 2
Chromosome 11
Gene Common Name(s) Fbrwt11;
Molecular Note This allele confers increased forebrain weight compared to DBA/2J. [MGI Ref ID J:143361]
 
Allele Symbol Gluchos1C57BL/6J
Allele Name C57BL/6J
Allele Type QTL
Strain of OriginC57BL/6J
Gene Symbol and Name Gluchos1, glucose homeostasis QTL 1
Chromosome 13
 
Allele Symbol Gluchos2C57BL/6J
Allele Name C57BL/6J
Allele Type QTL
Strain of OriginC57BL/6J
Gene Symbol and Name Gluchos2, glucose homeostasis QTL 2
Chromosome 11
 
Allele Symbol Gluchos3C57BL/6J
Allele Name C57BL/6J
Allele Type QTL
Strain of OriginC57BL/6J
Gene Symbol and Name Gluchos3, glucose homeostasis QTL 3
Chromosome 9
Molecular Note This allele confers 50% decreased plasma insulin at T30 during the intraperitoneal glucose tolerance test compared to C3H/HeH. [MGI Ref ID J:106692]
 
Allele Symbol Micrln
Allele Name non-responder
Allele Type QTL
Strain of Originmultiple strains
Gene Symbol and Name Micrl, microwave induced increase in complement receptor B cells
Chromosome 5
General Note The following inbred strains are homozygous for the recessive QTL, Micrl, and do not respond to microwave exposure by increasing splenic C3 receptor-bearing B cells: A/J, BALB/cJ, C3HeB/FeN, C57BL/6J, C57BL/10J (inferred from the response of two congenic lines "B10.BR", "B10.D2", "B10.D2"),C58/J, AK.B6-H2b, and B6.AK-H2k. These recombinant inbred strains are also non-responding: BXH2/Ty, BXH6/Ty, BXH7/Ty, BXH12/Ty, and BXH14/Ty.
 
Allele Symbol NntC57BL/6J
Allele Name C57BL/6J
Allele Type Spontaneous
Strain of OriginC57BL/6J
Gene Symbol and Name Nnt, nicotinamide nucleotide transhydrogenase
Chromosome 13
Gene Common Name(s) 4930423F13Rik; AI323702; BB168308; RIKEN cDNA 4930423F13 gene; expressed sequence AI323702; expressed sequence BB168308;
Molecular Note This allele contains a stretch of 17,814 bp missing between exons 6 and 12. RT-PCR demonstrated cDNA corresponding to exons 7-11 was absent. Mature protein was not detected in these mutants. [MGI Ref ID J:106692] [MGI Ref ID J:108213]
 
Allele Symbol P2rx7P451L
Allele Name P451L
Allele Type Spontaneous
Strain of Originvarious
Gene Symbol and Name P2rx7, purinergic receptor P2X, ligand-gated ion channel, 7
Chromosome 5
Gene Common Name(s) AI467586; P2X(7); P2X7; P2X7 receptor; P2X7R; expressed sequence AI467586;
Molecular Note A proline to leucine change at amino acid residue 451 is caused by a T to C transition at nucleic acid base 1352. This mutation is found in C57BL/6, C57BL/10, DBA/1, and DBA/2 and contrasts with the condition in BALB/c, NZW, NOD, 129, Mus caroli, M. spretus, M. musculus, and M. poschiavinus. The mutation lies within a C-terminal cytoplasmic domain homologous with the TNFR 1-death domain and with an SH3 binding protein. [MGI Ref ID J:79540]

Genotyping

Genotyping Information

Genotyping Protocols

Crb1rd8End Point, End Point Analysis
Kif1a, End Point Analysis
Y chromosome II, Standard PCR

Inbred mouse strains are maintained through sibling (sister x brother) matings; no genotyping required.

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Black BL; Croom J; Eisen EJ; Petro AE; Edwards CL; Surwit RS. 1998. Differential effects of fat and sucrose on body composition in A/J and C57BL/6 mice. Metabolism 47(11):1354-9. [PubMed: 9826212]  [MGI Ref ID J:50965]

Champy MF; Selloum M; Zeitler V; Caradec C; Jung B; Rousseau S; Pouilly L; Sorg T; Auwerx J. 2008. Genetic background determines metabolic phenotypes in the mouse. Mamm Genome 19(5):318-31. [PubMed: 18392653]  [MGI Ref ID J:137669]

Drake TA; Schadt E; Hannani K; Kabo JM; Krass K; Colinayo V; Greaser LE 3rd; Goldin J; Lusis AJ. 2001. Genetic loci determining bone density in mice with diet-induced atherosclerosis. Physiol Genomics 5(4):205-15. [PubMed: 11328966]  [MGI Ref ID J:69682]

Ishida BY; Blanche PJ; Nichols AV; Yashar M; Paigen B. 1991. Effects of atherogenic diet consumption on lipoproteins in mouse strains C57BL/6 and C3H. J Lipid Res 32(4):559-68. [PubMed: 1856605]  [MGI Ref ID J:109926]

Kirk EA; Moe GL; Caldwell MT; Lernmark JA; Wilson DL; LeBoeuf RC. 1995. Hyper- and hypo-responsiveness to dietary fat and cholesterol among inbred mice: searching for level and variability genes. J Lipid Res 36(7):1522-32. [PubMed: 7595076]  [MGI Ref ID J:28648]

Nishina PM; Verstuyft J; Paigen B. 1990. Synthetic low and high fat diets for the study of atherosclerosis in the mouse. J Lipid Res 31(5):859-69. [PubMed: 2380634]  [MGI Ref ID J:27046]

Paigen B. 1995. Genetics of responsiveness to high-fat and high- cholesterol diets in the mouse. Am J Clin Nutr 62(2):458S-462S. [PubMed: 7625360]  [MGI Ref ID J:28248]

Paigen B; Ishida BY; Verstuyft J; Winters RB; Albee D. 1990. Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice. Arteriosclerosis 10(2):316-23. [PubMed: 2317166]  [MGI Ref ID J:22615]

Paigen B; Morrow A; Brandon C; Mitchell D; Holmes P. 1985. Variation in susceptibility to atherosclerosis among inbred strains of mice. Atherosclerosis 57(1):65-73. [PubMed: 3841001]  [MGI Ref ID J:109950]

Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11. [PubMed: 15081119]  [MGI Ref ID J:89298]

Toye AA; Lippiat JD; Proks P; Shimomura K; Bentley L; Hugill A; Mijat V; Goldsworthy M; Moir L; Haynes A; Quarterman J; Freeman HC; Ashcroft FM; Cox RD. 2005. A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J mice. Diabetologia 48(4):675-86. [PubMed: 15729571]  [MGI Ref ID J:106692]

Waterston RH; Lindblad-Toh K; Birney E; Rogers J; Abril JF; Agarwal P; Agarwala R; Ainscough R; Alexandersson M; An P; Antonarakis SE; Attwood J; Baertsch R; Bailey J; Barlow K; Beck S; Berry E; Birren B; Bloom T; Bork P; Botcherby M; Bray N; Brent MR; Brown DG; Brown SD; Bult C; Burton J; Butler J; Campbell RD; Carninci P; Cawley S; Chiaromonte F; Chinwalla AT; Church DM; Clamp M; Clee C; Collins FS; Cook LL; Copley RR; Coulson A; Couronne O; Cuff J; Curwen V; Cutts T; Daly M; David R; Davies J; Delehaun. 2002. Initial sequencing and comparative analysis of the mouse genome. Nature 420(6915):520-62. [PubMed: 12466850]  [MGI Ref ID J:80507]

Additional References

Beamer WG; Donahue LR; Rosen CJ; Baylink DJ. 1996. Genetic variability in adult bone density among inbred strains of mice. Bone 18(5):397-403. [PubMed: 8739896]  [MGI Ref ID J:33789]

Beamer WG; Shultz KL; Churchill GA; Frankel WN; Baylink DJ; Rosen CJ; Donahue LR. 1999. Quantitative trait loci for bone density in C57BL/6J and CAST/EiJ inbred mice. Mamm Genome 10(11):1043-9. [PubMed: 10556421]  [MGI Ref ID J:58152]

Bultman SJ; Klebig ML; Michaud EJ; Sweet HO; Davisson MT; Woychik RP. 1994. Molecular analysis of reverse mutations from nonagouti (a) to black-and-tan (a(t)) and white-bellied agouti (Aw) reveals alternative forms of agouti transcripts. Genes Dev 8(4):481-90. [PubMed: 8125260]  [MGI Ref ID J:16984]

Bultman SJ; Michaud EJ; Woychik RP. 1992. Molecular characterization of the mouse agouti locus. Cell 71(7):1195-204. [PubMed: 1473152]  [MGI Ref ID J:3523]

Chen J; Astle CM; Harrison DE. 2000. Genetic regulation of primitive hematopoietic stem cell senescence. Exp Hematol 28(4):442-50. [PubMed: 10781902]  [MGI Ref ID J:61814]

Erway LC; Shiau YW; Davis RR; Krieg EF. 1996. Genetics of age-related hearing loss in mice. III. Susceptibility of inbred and F1 hybrid strains to noise-induced hearing loss. Hear Res 93(1-2):181-7. [PubMed: 8735078]  [MGI Ref ID J:33970]

Ewart SL; Kuperman D; Schadt E; Tankersley C; Grupe A; Shubitowski DM; Peltz G; Wills-Karp M. 2000. Quantitative trait loci controlling allergen-induced airway hyperresponsiveness in inbred mice. Am J Respir Cell Mol Biol 23(4):537-45. [PubMed: 11017920]  [MGI Ref ID J:66641]

Freeman HC; Hugill A; Dear NT; Ashcroft FM; Cox RD. 2006. Deletion of Nicotinamide Nucleotide Transhydrogenase: A New Quantitive Trait Locus Accounting for Glucose Intolerance in C57BL/6J Mice. Diabetes 55(7):2153-6. [PubMed: 16804088]  [MGI Ref ID J:109356]

Hollyfield JG; Bonilha VL; Rayborn ME; Yang X; Shadrach KG; Lu L; Ufret RL; Salomon RG; Perez VL. 2008. Oxidative damage-induced inflammation initiates age-related macular degeneration. Nat Med :. [PubMed: 18223656]  [MGI Ref ID J:129432]

Jiao S; Cole TG; Kitchens RT; Pfleger B; Schonfeld G. 1990. Genetic heterogeneity of plasma lipoproteins in the mouse: control of low density lipoprotein particle sizes by genetic factors. J Lipid Res 31(3):467-77. [PubMed: 1971301]  [MGI Ref ID J:15484]

Kumar V; Kim K; Joseph C; Kourrich S; Yoo SH; Huang HC; Vitaterna MH; de Villena FP; Churchill G; Bonci A; Takahashi JS. 2013. C57BL/6N mutation in Cytoplasmic FMRP interacting protein 2 regulates cocaine response. Science 342(6165):1508-12. [PubMed: 24357318]  [MGI Ref ID J:203183]

Le AD; Ko J; Chow S; Quan B. 1994. Alcohol consumption by C57BL/6, BALB/c, and DBA/2 mice in a limited access paradigm. Pharmacol Biochem Behav 47(2):375-8. [PubMed: 8146231]  [MGI Ref ID J:17161]

Mekada K; Abe K; Murakami A; Nakamura S; Nakata H; Moriwaki K; Obata Y; Yoshiki A. 2009. Genetic differences among C57BL/6 substrains. Exp Anim 58(2):141-9. [PubMed: 19448337]  [MGI Ref ID J:160204]

Miller MW; Duhl DM; Vrieling H; Cordes SP; Ollmann MM; Winkes BM; Barsh GS. 1993. Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation. Genes Dev 7(3):454-67. [PubMed: 8449404]  [MGI Ref ID J:4186]

Moy SS; Nadler JJ; Young NB; Perez A; Holloway LP; Barbaro RP; Barbaro JR; Wilson LM; Threadgill DW; Lauder JM; Magnuson TR; Crawley JN. 2007. Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains. Behav Brain Res 176(1):4-20. [PubMed: 16971002]  [MGI Ref ID J:138682]

Nguyen PV; Duffy SN; Young JZ. 2000. Differential maintenance and frequency-dependent tuning of LTP at hippocampal synapses of specific strains of inbred mice. J Neurophysiol 84(5):2484-93. [PubMed: 11067991]  [MGI Ref ID J:71278]

Nishina PM; Wang J; Toyofuku W; Kuypers FA; Ishida BY; Paigen B. 1993. Atherosclerosis and plasma and liver lipids in nine inbred strains of mice. Lipids 28(7):599-605. [PubMed: 8355588]  [MGI Ref ID J:13267]

O'Malley J; Matesic LE; Zink MC; Strandberg JD; Mooney ML; De Maio A; Reeves RH. 1998. Comparison of acute endotoxin-induced lesions in A/J and C57BL/6J mice. J Hered 89(6):525-30. [PubMed: 9864862]  [MGI Ref ID J:51631]

Parekh PI; Petro AE; Tiller JM; Feinglos MN; Surwit RS. 1998. Reversal of diet-induced obesity and diabetes in C57BL/6J mice. Metabolism 47(9):1089-96. [PubMed: 9751238]  [MGI Ref ID J:49858]

Parham K. 1997. Distortion product otoacoustic emissions in the C57BL/6J mouse model of age-related hearing loss. Hear Res 112(1-2):216-34. [PubMed: 9367243]  [MGI Ref ID J:44149]

Petkov PM; Ding Y; Cassell MA; Zhang W; Wagner G; Sargent EE; Asquith S; Crew V; Johnson KA; Robinson P; Scott VE; Wiles MV. 2004. An efficient SNP system for mouse genome scanning and elucidating strain relationships. Genome Res 14(9):1806-11. [PubMed: 15342563]  [MGI Ref ID J:151913]

Roberts JE; Watters JW; Ballard JD; Dietrich WF. 1998. Ltx1, a mouse locus that influences the susceptibility of macrophages to cytolysis caused by intoxication with Bacillus anthracis lethal factor, maps to chromosome 11. Mol Microbiol 29(2):581-91. [PubMed: 9720874]  [MGI Ref ID J:49726]

Rohan RM; Fernandez A; Udagawa T; Yuan J; D'Amato RJ. 2000. Genetic heterogeneity of angiogenesis in mice. FASEB J 14(7):871-6. [PubMed: 10783140]  [MGI Ref ID J:61808]

Rossmeisl M; Rim JS; Koza RA; Kozak LP. 2003. Variation in type 2 diabetes--related traits in mouse strains susceptible to diet-induced obesity. Diabetes 52(8):1958-66. [PubMed: 12882911]  [MGI Ref ID J:86027]

Sarna JR; Dyck RH; Whishaw IQ. 2000. The Dalila effect: C57BL6 mice barber whiskers by plucking. Behav Brain Res 108(1):39-45. [PubMed: 10680755]  [MGI Ref ID J:71538]

Schlagel CJ; Ahmed A. 1982. Evidence for genetic control of microwave-induced augmentation of complement receptor-bearing B lymphocytes. J Immunol 129(4):1530-3. [PubMed: 6980940]  [MGI Ref ID J:6835]

Smith BK; Andrews PK; West DB. 2000. Macronutrient diet selection in thirteen mouse strains. Am J Physiol Regul Integr Comp Physiol 278(4):R797-805. [PubMed: 10749765]  [MGI Ref ID J:61602]

Smith RS; Roderick TH; Sundberg JP. 1994. Microphthalmia and associated abnormalities in inbred black mice. Lab Anim Sci 44(6):551-60. [PubMed: 7898027]  [MGI Ref ID J:24131]

Vrieling H; Duhl DM; Millar SE; Miller KA; Barsh GS. 1994. Differences in dorsal and ventral pigmentation result from regional expression of the mouse agouti gene. Proc Natl Acad Sci U S A 91(12):5667-71. [PubMed: 8202545]  [MGI Ref ID J:18750]

Welkos SL; Keener TJ; Gibbs PH. 1986. Differences in susceptibility of inbred mice to Bacillus anthracis. Infect Immun 51(3):795-800. [PubMed: 3081444]  [MGI Ref ID J:8197]

West DB; Boozer CN; Moody DL; Atkinson RL. 1992. Dietary obesity in nine inbred mouse strains. Am J Physiol 262(6 Pt 2):R1025-32. [PubMed: 1621856]  [MGI Ref ID J:1348]

Whitehead GS; Walker JK; Berman KG; Foster WM; Schwartz DA. 2003. Allergen-induced airway disease is mouse strain dependent. Am J Physiol Lung Cell Mol Physiol 285(1):L32-42. [PubMed: 12626335]  [MGI Ref ID J:84265]

Zhu W; Gilmour MI. 2009. Comparison of allergic lung disease in three mouse strains after systemic or mucosal sensitization with ovalbumin antigen. Immunogenetics 61(3):199-207. [PubMed: 19224206]  [MGI Ref ID J:146790]

Zurita E; Chagoyen M; Cantero M; Alonso R; Gonzalez-Neira A; Lopez-Jimenez A; Lopez-Moreno JA; Landel CP; Benitez J; Pazos F; Montoliu L. 2010. Genetic polymorphisms among C57BL/6 mouse inbred strains. Transgenic Res :. [PubMed: 20506040]  [MGI Ref ID J:160203]

Ahrb-1 related

Benedict WF; Considine N; Nebert DW. 1973. Genetic differences in aryl hydrocarbon hydroxylase induction and benzo(a)pyrene-produced tumorigenesis in the mouse. Mol Pharmacol 9(2):266-77. [PubMed: 4123113]  [MGI Ref ID J:84312]

Boobis AR; Nebert DW. 1976. Genetic differences in the metabolism of carcinogens and in the binding of benzo (a) pyrene metabolites to DNA. Adv Enzyme Regul 15:339-62. [PubMed: 1030186]  [MGI Ref ID J:12156]

Bradfield CA; Glover E; Poland A. 1991. Purification and N-terminal amino acid sequence of the Ah receptor from the C57BL/6J mouse. Mol Pharmacol 39(1):13-9. [PubMed: 1846217]  [MGI Ref ID J:84440]

Burbach KM; Poland A; Bradfield CA. 1992. Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor. Proc Natl Acad Sci U S A 89(17):8185-9. [PubMed: 1325649]  [MGI Ref ID J:2256]

Castro DJ; Lohr CV; Fischer KA; Pereira CB; Williams DE. 2008. Lymphoma and lung cancer in offspring born to pregnant mice dosed with dibenzo[a,l]pyrene: the importance of in utero vs. lactational exposure. Toxicol Appl Pharmacol 233(3):454-8. [PubMed: 18848954]  [MGI Ref ID J:143604]

Chang C; Smith DR; Prasad VS; Sidman CL; Nebert DW; Puga A. 1993. Ten nucleotide differences, five of which cause amino acid changes, are associated with the Ah receptor locus polymorphism of C57BL/6 and DBA/2 mice. Pharmacogenetics 3(6):312-21. [PubMed: 8148872]  [MGI Ref ID J:17460]

Curran CP; Miller KA; Dalton TP; Vorhees CV; Miller ML; Shertzer HG; Nebert DW. 2006. Genetic differences in lethality of newborn mice treated in utero with coplanar versus non-coplanar hexabromobiphenyl. Toxicol Sci 89(2):454-64. [PubMed: 16291824]  [MGI Ref ID J:113285]

Ema M; Sogawa K; Watanabe N; Chujoh Y; Matsushita N; Gotoh O; Funae Y; Fujii-Kuriyama Y. 1992. cDNA cloning and structure of mouse putative Ah receptor. Biochem Biophys Res Commun 184(1):246-53. [PubMed: 1314586]  [MGI Ref ID J:477]

Gielen JE; Goujon FM; Nebert DW. 1972. Genetic regulation of aryl hydrocarbon hydroxylase induction. II. Simple Mendelian expression in mouse tissues in vivo. J Biol Chem 247(4):1125-37. [PubMed: 4110756]  [MGI Ref ID J:84250]

Goujon FM; Nebert DW; Gielen JE. 1972. Genetic expression of aryl hydrocarbon hydroxylase induction. IV. Interaction of various compounds with different forms of cytochrome P-450 and the effect on benzo(a)pyrene metabolism in vitro. Mol Pharmacol 8(6):667-80. [PubMed: 4118365]  [MGI Ref ID J:84252]

Harper PA; Golas CL; Okey AB. 1991. Ah receptor in mice genetically nonresponsive for cytochrome P4501A1 induction: cytosolic Ah receptor, transformation to the nuclear binding state, and induction of aryl hydrocarbon hydroxylase by halogenated and nonhalogenated aromatic hydrocarbons in embryonic tissues and cells. Mol Pharmacol 40(5):818-26. [PubMed: 1658612]  [MGI Ref ID J:2134]

Kerley-Hamilton JS; Trask HW; Ridley CJ; Dufour E; Lesseur C; Ringelberg CS; Moodie KL; Shipman SL; Korc M; Gui J; Shworak NW; Tomlinson CR. 2012. Inherent and benzo[a]pyrene-induced differential aryl hydrocarbon receptor signaling greatly affects life span, atherosclerosis, cardiac gene expression, and body and heart growth in mice. Toxicol Sci 126(2):391-404. [PubMed: 22228805]  [MGI Ref ID J:183715]

Kouri RE; Rude TH; Joglekar R; Dansette PM; Jerina DM; Atlas SA; Owens IS; Nebert DW. 1978. 2,3,7,8-tetrachlorodibenzo-p-dioxin as cocarcinogen causing 3-methylcholanthrene-initiated subcutaneous tumors in mice genetically 'nonresponsive' at Ah locus. Cancer Res 38(9):2777-83. [PubMed: 679184]  [MGI Ref ID J:84318]

Levova K; Moserova M; Nebert DW; Phillips DH; Frei E; Schmeiser HH; Arlt VM; Stiborova M. 2012. NAD(P)H:quinone oxidoreductase expression in Cyp1a-knockout and CYP1A-humanized mouse lines and its effect on bioactivation of the carcinogen aristolochic acid I. Toxicol Appl Pharmacol 265(3):360-7. [PubMed: 22982977]  [MGI Ref ID J:192865]

Lew BJ; Manickam R; Lawrence BP. 2011. Activation of the aryl hydrocarbon receptor during pregnancy in the mouse alters mammary development through direct effects on stromal and epithelial tissues. Biol Reprod 84(6):1094-102. [PubMed: 21270426]  [MGI Ref ID J:173706]

Moriguchi T; Motohashi H; Hosoya T; Nakajima O; Takahashi S; Ohsako S; Aoki Y; Nishimura N; Tohyama C; Fujii-Kuriyama Y; Yamamoto M. 2003. Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse. Proc Natl Acad Sci U S A 100(10):5652-7. [PubMed: 12730383]  [MGI Ref ID J:132380]

Nebert DW; Atlas SA; Guenthner TM; Kouri RE. 1978. The Ah locus: genetic regulation of the enzymes which metabolize polycyclic hydrocarbons and the risk of cancer. In: Polycyclic Hydrocarbons and Cancer: Chemistry, Molecular Biology and Environment. Academic Press, New York.  [MGI Ref ID J:30693]

Nebert DW; Considine N; Owens IS. 1973. Genetic expression of aryl hydrocarbon hydroxylase induction. VI. Control of other aromatic hydrocarbon-inducible mono-oxygenase activities at or near the same genetic locus. Arch Biochem Biophys 157(1):148-59. [PubMed: 4716952]  [MGI Ref ID J:84313]

Nebert DW; Gelboin HV. 1969. The in vivo and in vitro induction of aryl hydrocarbon hydroxylase in mammalian cells of different species, tissues, strains, and developmental and hormonal states. Arch Biochem Biophys 134(1):76-89. [PubMed: 4981257]  [MGI Ref ID J:84248]

Nebert DW; Gielen JE. 1972. Genetic regulation of aryl hydrocarbon hydroxylase induction in the mouse. Fed Proc 31(4):1315-25. [PubMed: 4114109]  [MGI Ref ID J:5282]

Nebert DW; Gielen JE; Goujon FM. 1972. Genetic expression of aryl hydrocarbon hydroxylase induction. 3. Changes in the binding of n-octylamine to cytochrome P-450. Mol Pharmacol 8(6):651-66. [PubMed: 4118364]  [MGI Ref ID J:84251]

Nebert DW; Goujon FM; Gielen JE. 1972. Aryl hydrocarbon hydroxylase induction by polycyclic hydrocarbons: simple autosomal dominant trait in the mouse. Nat New Biol 236(65):107-10. [PubMed: 4502804]  [MGI Ref ID J:84249]

Nebert DW; Robinson JR; Niwa A; Kumaki K; Poland AP. 1975. Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse. J Cell Physiol 85(2 Pt 2 Suppl 1):393-414. [PubMed: 1091656]  [MGI Ref ID J:84317]

Niwa A; Kumaki K; Nebert DW; Poland AP. 1975. Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse. Distinction between the 'responsive' homozygote and heterozygote at the Ah locus. Arch Biochem Biophys 166(2):559-64. [PubMed: 1119809]  [MGI Ref ID J:84316]

Nukaya M; Lin BC; Glover E; Moran SM; Kennedy GD; Bradfield CA. 2010. The aryl hydrocarbon receptor-interacting protein (AIP) is required for dioxin-induced hepatotoxicity but not for the induction of the Cyp1a1 and Cyp1a2 genes. J Biol Chem 285(46):35599-605. [PubMed: 20829355]  [MGI Ref ID J:166864]

Okey AB; Vella LM; Harper PA. 1989. Detection and characterization of a low affinity form of cytosolic Ah receptor in livers of mice nonresponsive to induction of cytochrome P1-450 by 3-methylcholanthrene. Mol Pharmacol 35(6):823-30. [PubMed: 2543914]  [MGI Ref ID J:27899]

Poel WE; Stanton D; Peters E; Wade HO. 1958. Comparative susceptibilities of seven inbred strains of mice to qualified applications of 3, 4-benzpyrene Proc Am Assoc Cancer Res 2:335.  [MGI Ref ID J:84245]

Poland A; Bradfield C. 1992. A brief review of the Ah locus. Tohoku J Exp Med 168(2):83-7. [PubMed: 1339107]  [MGI Ref ID J:12546]

Poland A; Glover E. 1990. Characterization and strain distribution pattern of the murine Ah receptor specified by the Ahd and Ahb-3 alleles. Mol Pharmacol 38(3):306-12. [PubMed: 2169579]  [MGI Ref ID J:34840]

Poland A; Glover E; Kende AS. 1976. Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase. J Biol Chem 251(16):4936-46. [PubMed: 956169]  [MGI Ref ID J:84247]

Poland A; Glover E; Taylor BA. 1987. The murine Ah locus: a new allele and mapping to chromosome 12. Mol Pharmacol 32(4):471-8. [PubMed: 2823093]  [MGI Ref ID J:8895]

Poland A; Palen D; Glover E. 1994. Analysis of the four alleles of the murine aryl hydrocarbon receptor. Mol Pharmacol 46(5):915-21. [PubMed: 7969080]  [MGI Ref ID J:22144]

Poland AP; Glover E; Robinson JR; Nebert DW. 1974. Genetic expression of aryl hydrocarbon hydroxylase activity. Induction of monooxygenase activities and cytochrome P1-450 formation by 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice genetically 'nonresponsive' to other aromatic hydrocarbons. J Biol Chem 249(17):5599-606. [PubMed: 4370044]  [MGI Ref ID J:84314]

Robinson JR; Considine N; Nebert DW. 1974. Genetic expression of aryl hydrocarbon hydroxylase induction. Evidence for the involvement of other genetic loci. J Biol Chem 249(18):5851-9. [PubMed: 4413562]  [MGI Ref ID J:84315]

Schmid FA; Demetriades MS; Schabel FM 3rd; Tarnowski GS. 1967. Toxicity of several cancerigenic polycyclic hydrocarbons and other agents in AKR and C57BL-6 mice. Cancer Res 27(3):563-7. [PubMed: 6021514]  [MGI Ref ID J:84246]

Schmid FA; Elmer I; Tarnowski GS. 1969. Genetic determination of differential inflammatory reactivity and subcutaneous tumor susceptibility of AKR-J and C57BL-6J mice to 7,12-dimethylbenz- [a]anthracene. Cancer Res 29(8):1585-9. [PubMed: 5807232]  [MGI Ref ID J:34134]

Schmid FA; Pena RC; Robinson W; Tarnowski GS. 1967. Toxicity of intraperitoneal injections of 7, 12-dimethylbenz[a]anthracene in inbred mice. Cancer Res 27(3):558-62. [PubMed: 6021513]  [MGI Ref ID J:26440]

Schmidt JV; Carver LA; Bradfield CA. 1993. Molecular characterization of the murine Ahr gene. Organization, promoter analysis, and chromosomal assignment. J Biol Chem 268(29):22203-9. [PubMed: 8408082]  [MGI Ref ID J:15153]

Smith AG; Clothier B; Robinson S; Scullion MJ; Carthew P; Edwards R; Luo J; Lim CK; Toledano M. 1998. Interaction between iron metabolism and 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice with variants of the Ahr gene: a hepatic oxidative mechanism. Mol Pharmacol 53(1):52-61. [PubMed: 9443932]  [MGI Ref ID J:45850]

Stiborova M; Levova K; Barta F; Shi Z; Frei E; Schmeiser HH; Nebert DW; Phillips DH; Arlt VM. 2012. Bioactivation versus detoxication of the urothelial carcinogen aristolochic acid I by human cytochrome P450 1A1 and 1A2. Toxicol Sci 125(2):345-58. [PubMed: 22086975]  [MGI Ref ID J:183662]

Taylor BA. 1971. Strain distribution and linkage tests of 7,12-dimethylbenzanthracene (DMBA) inflammatory response in mice. Life Sci I 10(19):1127-34. [PubMed: 5132702]  [MGI Ref ID J:5244]

Thomas PE; Hutton JJ; Taylor BA. 1973. Genetic relationship between aryl hydrocarbon hydroxylase inducibility and chemical carcinogen induced skin ulceration in mice. Genetics 74(4):655-9. [PubMed: 4750810]  [MGI Ref ID J:5387]

Thomas PE; Kouri RE; Hutton JJ. 1972. The genetics of aryl hydrocarbon hydroxylase induction in mice: a single gene difference between C57BL-6J and DBA-2J. Biochem Genet 6(2):157-68. [PubMed: 4666754]  [MGI Ref ID J:31977]

Yu Z; Mahadevan B; Lohr CV; Fischer KA; Louderback MA; Krueger SK; Pereira CB; Albershardt DJ; Baird WM; Bailey GS; Williams DE. 2006. Indole-3-carbinol in the maternal diet provides chemoprotection for the fetus against transplacental carcinogenesis by the polycyclic aromatic hydrocarbon dibenzo[a,l]pyrene. Carcinogenesis 27(10):2116-23. [PubMed: 16704990]  [MGI Ref ID J:113356]

Cdh23ahl related

Bosco A; Crish SD; Steele MR; Romero CO; Inman DM; Horner PJ; Calkins DJ; Vetter ML. 2012. Early reduction of microglia activation by irradiation in a model of chronic glaucoma. PLoS One 7(8):e43602. [PubMed: 22952717]  [MGI Ref ID J:191663]

Davis RR; Newlander JK; Ling X; Cortopassi GA; Krieg EF; Erway LC. 2001. Genetic basis for susceptibility to noise-induced hearing loss in mice. Hear Res 155(1-2):82-90. [PubMed: 11335078]  [MGI Ref ID J:69679]

Di Palma F; Pellegrino R; Noben-Trauth K. 2001. Genomic structure, alternative splice forms and normal and mutant alleles of cadherin 23 (Cdh23). Gene 281(1-2):31-41. [PubMed: 11750125]  [MGI Ref ID J:73941]

Fetoni AR; Picciotti PM; Paludetti G; Troiani D. 2011. Pathogenesis of presbycusis in animal models: a review. Exp Gerontol 46(6):413-25. [PubMed: 21211561]  [MGI Ref ID J:186964]

Han F; Yu H; Tian C; Chen HE; Benedict-Alderfer C; Zheng Y; Wang Q; Han X; Zheng QY. 2010. A new mouse mutant of the Cdh23 gene with early-onset hearing loss facilitates evaluation of otoprotection drugs. Pharmacogenomics J :. [PubMed: 20644563]  [MGI Ref ID J:174758]

Johnson KR; Erway LC; Cook SA; Willott JF; Zheng QY. 1997. A major gene affecting age-related hearing loss in C57BL/6J mice Hear Res 114(1-2):83-92. [PubMed: 9447922]  [MGI Ref ID J:44966]

Johnson KR; Longo-Guess C; Gagnon LH; Yu H; Zheng QY. 2008. A locus on distal chromosome 11 (ahl8) and its interaction with Cdh23 ahl underlie the early onset, age-related hearing loss of DBA/2J mice. Genomics 92(4):219-25. [PubMed: 18662770]  [MGI Ref ID J:139223]

Johnson KR; Yu H; Ding D; Jiang H; Gagnon LH; Salvi RJ. 2010. Separate and combined effects of Sod1 and Cdh23 mutations on age-related hearing loss and cochlear pathology in C57BL/6J mice. Hear Res 268(1-2):85-92. [PubMed: 20470874]  [MGI Ref ID J:163035]

Johnson KR; Zheng QY; Bykhovskaya Y; Spirina O; Fischel-Ghodsian N. 2001. A nuclear-mitochondrial DNA interaction affecting hearing impairment in mice. Nat Genet 27(2):191-4. [PubMed: 11175788]  [MGI Ref ID J:67312]

Johnson KR; Zheng QY; Noben-Trauth K. 2006. Strain background effects and genetic modifiers of hearing in mice. Brain Res 1091(1):79-88. [PubMed: 16579977]  [MGI Ref ID J:110459]

Johnson KR; Zheng QY; Weston MD; Ptacek LJ; Noben-Trauth K. 2005. The Mass1(frings) mutation underlies early onset hearing impairment in BUB/BnJ mice, a model for the auditory pathology of Usher syndrome IIC. Genomics 85(5):582-90. [PubMed: 15820310]  [MGI Ref ID J:97534]

Kane KL; Longo-Guess CM; Gagnon LH; Ding D; Salvi RJ; Johnson KR. 2012. Genetic background effects on age-related hearing loss associated with Cdh23 variants in mice. Hear Res 283(1-2):80-8. [PubMed: 22138310]  [MGI Ref ID J:183757]

Keithley EM; Canto C; Zheng QY; Fischel-Ghodsian N; Johnson KR. 2004. Age-related hearing loss and the ahl locus in mice. Hear Res 188(1-2):21-8. [PubMed: 14759567]  [MGI Ref ID J:87783]

Liu X; Bulgakov OV; Darrow KN; Pawlyk B; Adamian M; Liberman MC; Li T. 2007. Usherin is required for maintenance of retinal photoreceptors and normal development of cochlear hair cells. Proc Natl Acad Sci U S A 104(11):4413-8. [PubMed: 17360538]  [MGI Ref ID J:118927]

Manji SS; Williams LH; Miller KA; Ooms LM; Bahlo M; Mitchell CA; Dahl HH. 2011. A mutation in synaptojanin 2 causes progressive hearing loss in the ENU-mutagenised mouse strain Mozart. PLoS One 6(3):e17607. [PubMed: 21423608]  [MGI Ref ID J:171701]

Mathews CE; Leiter EH. 1999. Resistance of ALR/Lt islets to free radical-mediated diabetogenic stress is inherited as a dominant trait. Diabetes 48(11):2189-96. [PubMed: 10535453]  [MGI Ref ID J:109893]

Nadeau JH. 2003. Modifier genes and protective alleles in humans and mice. Curr Opin Genet Dev 13(3):290-5. [PubMed: 12787792]  [MGI Ref ID J:88012]

Noben-Trauth K; Latoche JR; Neely HR; Bennett B. 2010. Phenotype and genetics of progressive sensorineural hearing loss (Snhl1) in the LXS set of recombinant inbred strains of mice. PLoS One 5(7):e11459. [PubMed: 20628639]  [MGI Ref ID J:163117]

Noben-Trauth K; Zheng QY; Johnson KR. 2003. Association of cadherin 23 with polygenic inheritance and genetic modification of sensorineural hearing loss. Nat Genet 35(1):21-3. [PubMed: 12910270]  [MGI Ref ID J:86905]

Noben-Trauth K; Zheng QY; Johnson KR; Nishina PM. 1997. mdfw: a deafness susceptibility locus that interacts with deaf waddler (dfw). Genomics 44(3):266-72. [PubMed: 9325047]  [MGI Ref ID J:38429]

Perrin BJ; Sonnemann KJ; Ervasti JM. 2010. beta-actin and gamma-actin are each dispensable for auditory hair cell development but required for Stereocilia maintenance. PLoS Genet 6(10):e1001158. [PubMed: 20976199]  [MGI Ref ID J:167543]

Perrin BJ; Strandjord DM; Narayanan P; Henderson DM; Johnson KR; Ervasti JM. 2013. beta-Actin and Fascin-2 Cooperate to Maintain Stereocilia Length. J Neurosci 33(19):8114-21. [PubMed: 23658152]  [MGI Ref ID J:197137]

Vazquez AE; Jimenez AM; Martin GK; Luebke AE; Lonsbury-Martin BL. 2004. Evaluating cochlear function and the effects of noise exposure in the B6.CAST+Ahl mouse with distortion product otoacoustic emissions. Hear Res 194(1-2):87-96. [PubMed: 15276680]  [MGI Ref ID J:117746]

Zheng QY; Johnson KR. 2001. Hearing loss associated with the modifier of deaf waddler (mdfw) locus corresponds with age-related hearing loss in 12 inbred strains of mice. Hear Res 154(1-2):45-53. [PubMed: 11423214]  [MGI Ref ID J:70964]

Zheng QY; Scarborough JD; Zheng Y; Yu H; Choi D; Gillespie PG. 2012. Digenic inheritance of deafness caused by 8J allele of myosin-VIIA and mutations in other Usher I genes. Hum Mol Genet 21(11):2588-98. [PubMed: 22381527]  [MGI Ref ID J:183898]

Zilberstein Y; Liberman MC; Corfas G. 2012. Inner hair cells are not required for survival of spiral ganglion neurons in the adult cochlea. J Neurosci 32(2):405-10. [PubMed: 22238076]  [MGI Ref ID J:179911]

Fbrwt1C57BL/6J related

Lu L; Wei L; Peirce JL; Wang X; Zhou J; Homayouni R; Williams RW; Airey DC. 2008. Using gene expression databases for classical trait QTL candidate gene discovery in the BXD recombinant inbred genetic reference population: mouse forebrain weight. BMC Genomics 9:444. [PubMed: 18817551]  [MGI Ref ID J:143361]

Fbrwt2C57BL/6J related

Lu L; Wei L; Peirce JL; Wang X; Zhou J; Homayouni R; Williams RW; Airey DC. 2008. Using gene expression databases for classical trait QTL candidate gene discovery in the BXD recombinant inbred genetic reference population: mouse forebrain weight. BMC Genomics 9:444. [PubMed: 18817551]  [MGI Ref ID J:143361]

Gluchos1C57BL/6J related

Freeman HC; Hugill A; Dear NT; Ashcroft FM; Cox RD. 2006. Deletion of Nicotinamide Nucleotide Transhydrogenase: A New Quantitive Trait Locus Accounting for Glucose Intolerance in C57BL/6J Mice. Diabetes 55(7):2153-6. [PubMed: 16804088]  [MGI Ref ID J:109356]

Micrln related

Schlagel CJ; Ahmed A. 1982. Evidence for genetic control of microwave-induced augmentation of complement receptor-bearing B lymphocytes. J Immunol 129(4):1530-3. [PubMed: 6980940]  [MGI Ref ID J:6835]

NntC57BL/6J related

Freeman HC; Hugill A; Dear NT; Ashcroft FM; Cox RD. 2006. Deletion of Nicotinamide Nucleotide Transhydrogenase: A New Quantitive Trait Locus Accounting for Glucose Intolerance in C57BL/6J Mice. Diabetes 55(7):2153-6. [PubMed: 16804088]  [MGI Ref ID J:109356]

Huang TT; Naeemuddin M; Elchuri S; Yamaguchi M; Kozy HM; Carlson EJ; Epstein CJ. 2006. Genetic modifiers of the phenotype of mice deficient in mitochondrial superoxide dismutase. Hum Mol Genet 15(7):1187-94. [PubMed: 16497723]  [MGI Ref ID J:108213]

Kim A; Chen CH; Ursell P; Huang TT. 2010. Genetic modifier of mitochondrial superoxide dismutase-deficient mice delays heart failure and prolongs survival. Mamm Genome 21(11-12):534-42. [PubMed: 21069343]  [MGI Ref ID J:166767]

Meimaridou E; Kowalczyk J; Guasti L; Hughes CR; Wagner F; Frommolt P; Nurnberg P; Mann NP; Banerjee R; Saka HN; Chapple JP; King PJ; Clark AJ; Metherell LA. 2012. Mutations in NNT encoding nicotinamide nucleotide transhydrogenase cause familial glucocorticoid deficiency. Nat Genet 44(7):740-2. [PubMed: 22634753]  [MGI Ref ID J:185986]

Navarro SJ; Trinh T; Lucas CA; Ross AJ; Waymire KG; Macgregor GR. 2012. The C57BL/6J Mouse Strain Background Modifies the Effect of a Mutation in Bcl2l2. G3 (Bethesda) 2(1):99-102. [PubMed: 22384386]  [MGI Ref ID J:186862]

Parker N; Vidal-Puig AJ; Azzu V; Brand MD. 2009. Dysregulation of glucose homeostasis in nicotinamide nucleotide transhydrogenase knockout mice is independent of uncoupling protein 2. Biochim Biophys Acta 1787(12):1451-7. [PubMed: 19539600]  [MGI Ref ID J:153452]

Ronchi JA; Figueira TR; Ravagnani FG; Oliveira HC; Vercesi AE; Castilho RF. 2013. A spontaneous mutation in the nicotinamide nucleotide transhydrogenase gene of C57BL/6J mice results in mitochondrial redox abnormalities. Free Radic Biol Med 63:446-56. [PubMed: 23747984]  [MGI Ref ID J:205166]

Wong N; Blair AR; Morahan G; Andrikopoulos S. 2010. The deletion variant of nicotinamide nucleotide transhydrogenase (Nnt) does not affect insulin secretion or glucose tolerance. Endocrinology 151(1):96-102. [PubMed: 19906813]  [MGI Ref ID J:168281]

P2rx7P451L related

Adriouch S; Dox C; Welge V; Seman M; Koch-Nolte F; Haag F. 2002. Cutting Edge: A Natural P451L Mutation in the Cytoplasmic Domain Impairs the Function of the Mouse P2X7 Receptor. J Immunol 169(8):4108-12. [PubMed: 12370338]  [MGI Ref ID J:79540]

Le Stunff H; Auger R; Kanellopoulos J; Raymond MN. 2004. The Pro-451 to Leu polymorphism within the C-terminal tail of P2X7 receptor impairs cell death but not phospholipase D activation in murine thymocytes. J Biol Chem 279(17):16918-26. [PubMed: 14761980]  [MGI Ref ID J:89513]

Sorge RE; Trang T; Dorfman R; Smith SB; Beggs S; Ritchie J; Austin JS; Zaykin DV; Meulen HV; Costigan M; Herbert TA; Yarkoni-Abitbul M; Tichauer D; Livneh J; Gershon E; Zheng M; Tan K; John SL; Slade GD; Jordan J; Woolf CJ; Peltz G; Maixner W; DiatchenkoL; Seltzer Z; Salter MW; Mogil JS. 2012. Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity. Nat Med 18(4):595-9. [PubMed: 22447075]  [MGI Ref ID J:183554]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX1
Room Number           AX28
Room Number           AX29
Room Number           AX4
Room Number           AX8
Room Number           MP14
Room Number           MP15
Room Number           MP23
Room Number           RB03
Room Number           RB04
Room Number           RB05
Room Number           RB07
Room Number           RB08
Room Number           RB11

Colony Maintenance

Mating SystemSibling x Sibling         (Female x Male)   01-MAR-06
Breeding Considerations This strain is a good breeder.
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Weeks of AgePrice per mouse (US dollars $)Gender
3 weeks $19.85Female  
$18.15Male  
4 weeks $19.85Female  
$18.15Male  
5 weeks $21.25Female  
$19.85Male  
6 weeks $21.25Female  
$19.85Male  
7 weeks $24.35Female  
$23.95Male  
8 weeks $24.85Female  
$23.95Male  
9 weeks $24.85Female  
$23.95Male  
10 weeks $29.65Female  
$29.95Male  
11 weeks $29.65Female  
$29.95Male  
12 weeks $30.50Female  
$29.95Male  
13 weeks $33.00Female  
$32.35Male  
14 weeks $35.45Female  
$34.80Male  
15 weeks $37.80Female  
$37.10Male  
16 weeks $40.35Female  
$39.60Male  
17 weeks $42.90Female  
$42.10Male  
18 weeks $45.35Female  
$44.50Male  
19 weeks $47.70Female  
$46.80Male  
20 weeks $50.15Female  
$49.20Male  
21 weeks $52.60Female  
$51.65Male  
22 weeks $55.25Female  
$54.20Male  
23 weeks $57.70Female  
$56.60Male  
24 weeks $60.15Female  
$66.45Male  

Standard Supply

JAX Ready Strain®. Most popular strains. Readily available in any quantity you need.

Supply Notes

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Weeks of AgePrice per mouse (US dollars $)Gender
3 weeks $25.90Female  
$23.60Male  
4 weeks $25.90Female  
$23.60Male  
5 weeks $27.70Female  
$25.90Male  
6 weeks $27.70Female  
$25.90Male  
7 weeks $31.70Female  
$31.20Male  
8 weeks $32.40Female  
$31.20Male  
9 weeks $32.40Female  
$31.20Male  
10 weeks $38.60Female  
$39.00Male  
11 weeks $38.60Female  
$39.00Male  
12 weeks $39.70Female  
$39.00Male  
13 weeks $42.90Female  
$42.10Male  
14 weeks $46.10Female  
$45.30Male  
15 weeks $49.20Female  
$48.30Male  
16 weeks $52.50Female  
$51.50Male  
17 weeks $55.80Female  
$54.80Male  
18 weeks $59.00Female  
$57.90Male  
19 weeks $62.10Female  
$60.90Male  
20 weeks $65.20Female  
$64.00Male  
21 weeks $68.40Female  
$67.20Male  
22 weeks $71.90Female  
$70.50Male  
23 weeks $75.10Female  
$73.60Male  
24 weeks $78.20Female  
$86.40Male  

Standard Supply

JAX Ready Strain®. Most popular strains. Readily available in any quantity you need.

Supply Notes

  • Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
  • This strain is available from some international Charles River (CR) breeding facilities in Japan and/or Europe. For more information, see the Worldwide Distributor List for JAX® Mice.
View USA Canada and Mexico Pricing View International Pricing

Standard Supply

JAX Ready Strain®. Most popular strains. Readily available in any quantity you need.

General Supply Notes



  •       

Important Note

This strain is homozygous for Cdh23ahl, the age related hearing loss 1 mutation, which on this background results in progressive hearing loss with onset after 10 months of age.

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Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

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MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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