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- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
- Health & care
- References
- Pricing & purchasing
- Terms of use
Description
Strain Information
Type Inbred Strain; Additional information on Inbred Strains. Visit our online Nomenclature tutorial. Mating System Sibling x Sibling (Female x Male) 01-MAR-06 Breeding Considerations This strain is an exceptional breeder. Species laboratory mouse H2 Haplotype b Generation F254 (17-SEP-12)
Generation Definitions
View larger imageAppearance
black
Related Genotype: a/aDescription
C57BL/10J is a substrain of C57BL, and shares a common origin with C57BL/6J (Stock No. 000664), which is one of the most widely used inbred strains. Coat color is black (non-agouti), a/a. The C57BL/10J substrain is similar to the C57BL/6J substrain, but allelic variants have been described at the H9, Igh2 and Lv loci. C57BL/10J mice have a long life-span (826 +/-29 days in males, 693 +/- 31 days in females). Overall tumor incidence is 33% in males and 31% in females, most of which is due to lymphoma. C57BL/10J mice are prone to dermatitis, which is a common problem in the C57BL strain. C57BL/10J mice are a valuable immunological research tool. They have a high lymphocyte phytohaemagglutinin response, a good immune response to ovalbumin, a poor response to DNP-keyhole limpet haemocyanin and are resistant to induction of passive cutaneous anaphylaxis (IgG1- and IgE- mediated). They are susceptible to immunosuppression of contact hypersensitivity by ultraviolet light, highly susceptible to TNBS-induced colitis and moderately susceptible to experimental allergic encephalomyelitis.
Related Strains
C57BL Strains
003752 C57BL/10ScNJ 000476 C57BL/10ScSnJ 000666 C57BL/10SnJ 001822 C57BL/10SxJ 001197 C57BL/10WtRkJ 000663 C57BL/6By 001139 C57BL/6ByJ 009123 C57BL/6HaJ 000664 C57BL/6J 000924 C57BL/6JEiJ 005304 C57BL/6NJ View C57BL Strains (11 strains)
000646 A/J 000651 BALB/cJ 000009 BXH14/TyJ 000038 BXH6/TyJ 000014 BXH7/TyJ 000664 C57BL/6J 000669 C58/J
000032 BXH10/TyJ 000033 BXH19/TyJ 000011 BXH4/TyJ 000076 BXH8/TyJ 000008 BXH9/TyJ 000260 JGBF/LeJ 000072 JGBF/LeTyJ
005576 B6.129P2-P2rx7tm1Gab/J 015809 NOD.129P2(B6)-P2rx7tm1Gab/DvsJ
Additional Web Information
JAX® NOTES, April 1988; 433. H-2 Haplotypes of Mice from Jackson Laboratory Production Colonies.
JAX® NOTES, Fall 1995; 463. Inbred C57 Black Mice: Microphthalmia and Ocular Infections.
Phenotype
Phenotype Information
Mouse Phenome Database
Festing Inbred Strain Characteristics: C57BL
This mouse can be used to support research in many areas including:
Research Tools
General Purpose
Immunology and Inflammation Research
background strain for histocompatibility congenics
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Micrln | ||
|---|---|---|---|
| Allele Name | non-responder | ||
| Allele Type | QTL | ||
| Strain of Origin | multiple strains | ||
| Gene Symbol and Name | Micrl, microwave induced increase in complement receptor B cells | ||
| Chromosome | 5 | ||
| General Note |
The following inbred strains are homozygous for the recessive QTL, Micrl | ||
| Allele Symbol | P2rx7P451L | ||
| Allele Name | P451L | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | various | ||
| Gene Symbol and Name | P2rx7, purinergic receptor P2X, ligand-gated ion channel, 7 | ||
| Chromosome | 5 | ||
| Gene Common Name(s) | AI467586; P2X(7); P2X7; P2X7 receptor; P2X7R; expressed sequence AI467586; | ||
| Molecular Note | A proline to leucine change at amino acid residue 451 is caused by a T to C transition at nucleic acid base 1352. This mutation is found in C57BL/6, C57BL/10, DBA/1, and DBA/2 and contrasts with the condition in BALB/c, NZW, NOD, 129, Mus caroli, M. spretus, M. musculus, and M. poschiavinus. The mutation lies within a C-terminal cytoplasmic domain homologous with the TNFR 1-death domain and with an SH3 binding protein. [MGI Ref ID J:79540] | ||
Genotyping
Genotyping Information
Inbred mouse strains are maintained through sibling (sister x brother) matings; no genotyping required.
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Additional References
Fichtner-Feigl S; Fuss IJ; Preiss JC; Strober W; Kitani A. 2005. Treatment of murine Th1- and Th2-mediated inflammatory bowel disease with NF-kappa B decoy oligonucleotides. J Clin Invest 115(11):3057-71. [PubMed: 16239967] [MGI Ref ID J:145688]
International Nomenclature Committee. 1952. COMMITTEE on Standardized Nomenclature for Inbred Strains of Mice Cancer Res 12(8):602-13. [PubMed: 14945054] [MGI Ref ID J:166288]
Schlagel CJ; Ahmed A. 1982. Evidence for genetic control of microwave-induced augmentation of complement receptor-bearing B lymphocytes. J Immunol 129(4):1530-3. [PubMed: 6980940] [MGI Ref ID J:6835]
Micrln relatedP2rx7P451L relatedSchlagel CJ; Ahmed A. 1982. Evidence for genetic control of microwave-induced augmentation of complement receptor-bearing B lymphocytes. J Immunol 129(4):1530-3. [PubMed: 6980940] [MGI Ref ID J:6835]
Adriouch S; Dox C; Welge V; Seman M; Koch-Nolte F; Haag F. 2002. Cutting Edge: A Natural P451L Mutation in the Cytoplasmic Domain Impairs the Function of the Mouse P2X7 Receptor. J Immunol 169(8):4108-12. [PubMed: 12370338] [MGI Ref ID J:79540]
Le Stunff H; Auger R; Kanellopoulos J; Raymond MN. 2004. The Pro-451 to Leu polymorphism within the C-terminal tail of P2X7 receptor impairs cell death but not phospholipase D activation in murine thymocytes. J Biol Chem 279(17):16918-26. [PubMed: 14761980] [MGI Ref ID J:89513]
Sorge RE; Trang T; Dorfman R; Smith SB; Beggs S; Ritchie J; Austin JS; Zaykin DV; Meulen HV; Costigan M; Herbert TA; Yarkoni-Abitbul M; Tichauer D; Livneh J; Gershon E; Zheng M; Tan K; John SL; Slade GD; Jordan J; Woolf CJ; Peltz G; Maixner W; DiatchenkoL; Seltzer Z; Salter MW; Mogil JS. 2012. Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity. Nat Med 18(4):595-9. [PubMed: 22447075] [MGI Ref ID J:183554]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX9
Room Number RB08
Colony Maintenance
Mating System Sibling x Sibling (Female x Male) 01-MAR-06 Breeding Considerations This strain is an exceptional breeder. Diet Information LabDiet® 5K52/5K67
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Live Mice
Weeks of Age Price per mouse (US dollars $) Gender 3 weeks $22.80 Female $21.95 Male 4 weeks $22.80 Female $21.95 Male 5 weeks $22.80 Female or Male 6 weeks $25.45 Female or Male 7 weeks $28.05 Female or Male 8 weeks $30.70 Female or Male 9 weeks $33.35 Female or Male 10 weeks $36.00 Female or Male 11 weeks $38.65 Female or Male 12 weeks $41.25 Female or Male 13 weeks $43.90 Female or Male 14 weeks $46.55 Female or Male 15 weeks $49.20 Female or Male Standard Supply
Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.
Supply Notes
- Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
| Pricing for International shipping destinations |
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Live Mice
Weeks of Age Price per mouse (US dollars $) Gender 3 weeks $29.70 Female $28.60 Male 4 weeks $29.70 Female $28.60 Male 5 weeks $29.70 Female or Male 6 weeks $33.10 Female or Male 7 weeks $36.50 Female or Male 8 weeks $40.00 Female or Male 9 weeks $43.40 Female or Male 10 weeks $46.80 Female or Male 11 weeks $50.30 Female or Male 12 weeks $53.70 Female or Male 13 weeks $57.10 Female or Male 14 weeks $60.60 Female or Male 15 weeks $64.00 Female or Male Standard Supply
Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.
Supply Notes
- Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
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Standard Supply
Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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