Strain Name:

C57BL/10J

Stock Number:

000665

Order this mouse

Availability:

Level 3

Common Names: Black 10;     Black 10 J;    
The C57BL/10J substrain is similar to the C57BL/6J substrain, but allelic variants have been described at the H9, Igh2 and Lv loci. C57BL/10J mice are a valuable immunological research tool. They have a high lymphocyte phytohaemagglutinin response, a good immune response to ovalbumin, a poor response to DNP-keyhole limpet haemocyanin and are resistant to induction of passive cutaneous anaphylaxis (IgG1- and IgE- mediated). They are susceptible to immunosuppression of contact hypersensitivity by ultraviolet light, highly susceptible to TNBS-induced colitis and moderately susceptible to experimental allergic encephalomyelitis

Description

Strain Information

Type Inbred Strain;
Additional information on Inbred Strains.
Visit our online Nomenclature tutorial.
Mating SystemSibling x Sibling         (Female x Male)   01-MAR-06
Breeding Considerations This strain is an exceptional breeder.
Specieslaboratory mouse
H2 Haplotypeb
GenerationF254 (17-SEP-12)
Generation Definitions

View larger image

Appearance
black
Related Genotype: a/a

Description
C57BL/10J is a substrain of C57BL, and shares a common origin with C57BL/6J (Stock No. 000664), which is one of the most widely used inbred strains. Coat color is black (non-agouti), a/a. The C57BL/10J substrain is similar to the C57BL/6J substrain, but allelic variants have been described at the H9, Igh2 and Lv loci. C57BL/10J mice have a long life-span (826 +/-29 days in males, 693 +/- 31 days in females). Overall tumor incidence is 33% in males and 31% in females, most of which is due to lymphoma. C57BL/10J mice are prone to dermatitis, which is a common problem in the C57BL strain. C57BL/10J mice are a valuable immunological research tool. They have a high lymphocyte phytohaemagglutinin response, a good immune response to ovalbumin, a poor response to DNP-keyhole limpet haemocyanin and are resistant to induction of passive cutaneous anaphylaxis (IgG1- and IgE- mediated). They are susceptible to immunosuppression of contact hypersensitivity by ultraviolet light, highly susceptible to TNBS-induced colitis and moderately susceptible to experimental allergic encephalomyelitis.

Development
The C57BL strain created by C.C. Little in the 1920's gave rise to the C57BL/6 and C57BL/10 substrains sometime before 1937, and the C57BL/10J substrain was separated from other C57BL/10 substrains in 1947.

Related Strains

C57BL Strains
003752   C57BL/10ScNJ
000476   C57BL/10ScSnJ
000666   C57BL/10SnJ
001822   C57BL/10SxJ
001197   C57BL/10WtRkJ
000663   C57BL/6By
001139   C57BL/6ByJ
009123   C57BL/6HaJ
000664   C57BL/6J
000924   C57BL/6JEiJ
005304   C57BL/6NJ
View C57BL Strains     (11 strains)

Strains carrying   Micrln allele
000646   A/J
000651   BALB/cJ
000009   BXH14/TyJ
000038   BXH6/TyJ
000014   BXH7/TyJ
000664   C57BL/6J
000669   C58/J
View Strains carrying   Micrln     (7 strains)

Strains carrying   P2rx7P451L allele
000664   C57BL/6J
000670   DBA/1J
000671   DBA/2J
View Strains carrying   P2rx7P451L     (3 strains)

Strains carrying other alleles of Micrl
000032   BXH10/TyJ
000033   BXH19/TyJ
000011   BXH4/TyJ
000076   BXH8/TyJ
000008   BXH9/TyJ
000260   JGBF/LeJ
000072   JGBF/LeTyJ
View Strains carrying other alleles of Micrl     (7 strains)

Strains carrying other alleles of P2rx7
005576   B6.129P2-P2rx7tm1Gab/J
015809   NOD.129P2(B6)-P2rx7tm1Gab/DvsJ
View Strains carrying other alleles of P2rx7     (2 strains)

Additional Web Information

JAX® NOTES, April 1988; 433. H-2 Haplotypes of Mice from Jackson Laboratory Production Colonies.
JAX® NOTES, Fall 1995; 463. Inbred C57 Black Mice: Microphthalmia and Ocular Infections.

Phenotype

Phenotype Information

View Phenotypic Data

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Research Tools
General Purpose
Immunology, Inflammation and Autoimmunity Research
      background strain for histocompatibility congenics

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Micrln
Allele Name non-responder
Allele Type QTL
Strain of Originmultiple strains
Gene Symbol and Name Micrl, microwave induced increase in complement receptor B cells
Chromosome 5
General Note The following inbred strains are homozygous for the recessive QTL, Micrl, and do not respond to microwave exposure by increasing splenic C3 receptor-bearing B cells: A/J, BALB/cJ, C3HeB/FeN, C57BL/6J, C57BL/10J (inferred from the response of two congenic lines "B10.BR", "B10.D2", "B10.D2"),C58/J, AK.B6-H2b, and B6.AK-H2k. These recombinant inbred strains are also non-responding: BXH2/Ty, BXH6/Ty, BXH7/Ty, BXH12/Ty, and BXH14/Ty.
 
Allele Symbol P2rx7P451L
Allele Name P451L
Allele Type Spontaneous
Strain of Originvarious
Gene Symbol and Name P2rx7, purinergic receptor P2X, ligand-gated ion channel, 7
Chromosome 5
Gene Common Name(s) AI467586; P2X(7); P2X7; P2X7 receptor; P2X7R; expressed sequence AI467586;
Molecular Note A proline to leucine change at amino acid residue 451 is caused by a T to C transition at nucleic acid base 1352. This mutation is found in C57BL/6, C57BL/10, DBA/1, and DBA/2 and contrasts with the condition in BALB/c, NZW, NOD, 129, Mus caroli, M. spretus, M. musculus, and M. poschiavinus. The mutation lies within a C-terminal cytoplasmic domain homologous with the TNFR 1-death domain and with an SH3 binding protein. [MGI Ref ID J:79540]

Genotyping

Genotyping Information

Inbred mouse strains are maintained through sibling (sister x brother) matings; no genotyping required.

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Fichtner-Feigl S; Fuss IJ; Preiss JC; Strober W; Kitani A. 2005. Treatment of murine Th1- and Th2-mediated inflammatory bowel disease with NF-kappa B decoy oligonucleotides. J Clin Invest 115(11):3057-71. [PubMed: 16239967]  [MGI Ref ID J:145688]

International Nomenclature Committee. 1952. COMMITTEE on Standardized Nomenclature for Inbred Strains of Mice Cancer Res 12(8):602-13. [PubMed: 14945054]  [MGI Ref ID J:166288]

Schlagel CJ; Ahmed A. 1982. Evidence for genetic control of microwave-induced augmentation of complement receptor-bearing B lymphocytes. J Immunol 129(4):1530-3. [PubMed: 6980940]  [MGI Ref ID J:6835]

Micrln related

Schlagel CJ; Ahmed A. 1982. Evidence for genetic control of microwave-induced augmentation of complement receptor-bearing B lymphocytes. J Immunol 129(4):1530-3. [PubMed: 6980940]  [MGI Ref ID J:6835]

P2rx7P451L related

Adriouch S; Dox C; Welge V; Seman M; Koch-Nolte F; Haag F. 2002. Cutting Edge: A Natural P451L Mutation in the Cytoplasmic Domain Impairs the Function of the Mouse P2X7 Receptor. J Immunol 169(8):4108-12. [PubMed: 12370338]  [MGI Ref ID J:79540]

Le Stunff H; Auger R; Kanellopoulos J; Raymond MN. 2004. The Pro-451 to Leu polymorphism within the C-terminal tail of P2X7 receptor impairs cell death but not phospholipase D activation in murine thymocytes. J Biol Chem 279(17):16918-26. [PubMed: 14761980]  [MGI Ref ID J:89513]

Sorge RE; Trang T; Dorfman R; Smith SB; Beggs S; Ritchie J; Austin JS; Zaykin DV; Meulen HV; Costigan M; Herbert TA; Yarkoni-Abitbul M; Tichauer D; Livneh J; Gershon E; Zheng M; Tan K; John SL; Slade GD; Jordan J; Woolf CJ; Peltz G; Maixner W; DiatchenkoL; Seltzer Z; Salter MW; Mogil JS. 2012. Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity. Nat Med 18(4):595-9. [PubMed: 22447075]  [MGI Ref ID J:183554]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX28
Room Number           AX9
Room Number           RB08

Colony Maintenance

Mating SystemSibling x Sibling         (Female x Male)   01-MAR-06
Breeding Considerations This strain is an exceptional breeder.
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Weeks of AgePrice per mouse (US dollars $)Gender
3 weeks $26.65Female  
$25.65Male  
4 weeks $26.65Female  
$25.65Male  
5 weeks $26.65Female or Male  
6 weeks $29.70Female or Male  
7 weeks $32.75Female or Male  
8 weeks $35.85Female or Male  
9 weeks $38.95Female or Male  
10 weeks $42.05Female or Male  
11 weeks $45.10Female or Male  
12 weeks $48.15Female or Male  
13 weeks $51.25Female or Male  
14 weeks $54.30Female or Male  
15 weeks $57.45Female or Male  

Standard Supply

Level 3. Up to 50 mice. Larger quantities or custom orders arranged upon request.

Supply Notes

  • This strain is available from both the Bar Harbor, Maine and Sacramento, Calif. facilities.
  • Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Weeks of AgePrice per mouse (US dollars $)Gender
3 weeks $34.70Female  
$33.40Male  
4 weeks $34.70Female  
$33.40Male  
5 weeks $34.70Female or Male  
6 weeks $38.70Female or Male  
7 weeks $42.60Female or Male  
8 weeks $46.70Female or Male  
9 weeks $50.70Female or Male  
10 weeks $54.70Female or Male  
11 weeks $58.70Female or Male  
12 weeks $62.60Female or Male  
13 weeks $66.70Female or Male  
14 weeks $70.60Female or Male  
15 weeks $74.70Female or Male  

Standard Supply

Level 3. Up to 50 mice. Larger quantities or custom orders arranged upon request.

Supply Notes

  • Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Level 3. Up to 50 mice. Larger quantities or custom orders arranged upon request.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


(6.6)