JAX Mice Database - 000671 DBA/2J

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Strain Name:	DBA/2J
Stock Number:	000671
Availability:	Level 1

Price and Supply Information
General Terms and Conditions

Strain Common Names	D2; D2J;
Genes & Alleles	Cdh23; Cdh23^ahl; Gpnmb; Gpnmb^R150X; Hc; Hc⁰; Tyrp1; Tyrp1^isa;

Product Information

Strain Details

Type Inbred Strain

Additional information on Inbred Strains.

Mating System Sibling x Sibling (Female x Male)

Species laboratory mouse

H2 Haplotype d

Generation F223p (03-JAN-08)

Appearance
dilute brown
Related Genotype: a/a Tyrp1^b/Tyrp1^b Myo5a^d/Myo5a^d
Important Note
This strain is homozygous for Cdh23^ahl, the age related hearing loss 1 mutation, which on this background results in progressive hearing loss that is already severe by 3 months of age.
Strain Description
DBA/2J is a widely used inbred strain that is valuable in a large number of research areas, including cardiovascular biology, neurobiology, and sensorineural research. Its characteristics are often contrasted with those of the C57BL/6J inbred strain (Stock No. 000664). DBA/2J mice show a low susceptibility to developing atherosclerotic aortic lesions (20 to 350 um2 atherosclerotic aortic lesions /aortic cross-section) following 14 weeks on an atherogenic diet (1.25% cholesterol, 0.5% cholic acid and 15% fat). They also exhibit high-frequency hearing loss beginning roughly at the time of weaning/adolescence (between 3-4 weeks of age) and becoming severe by 2-3 months of age. This strain possesses three recessive alleles that cause progressive cochlear pathology initially affecting the organ of Corti. Decreasing anteroventral cochlear nucleus volume decreases and neuron loss parallel the progression of peripheral hearing loss. Young DBA/2J inbred mice are also susceptible to audiogenic seizures.
Aging DBA/2J mice develop progressive eye abnormalities that closely mimic human hereditary glaucoma. Defects include iris pigment dispersion, iris atrophy, anterior synechia (adhesion of the iris to the cornea), and elevated intraocularpressure (IOP). The onset of disease symptoms begins between 3 and 4 months of age with 56% of females and 15% of males showing signs of iris pigment epithelium loss and transillumination of the peripheral iris. By 6 to 7 months of age, all mice demonstrate significant widespread transillumination and thickening of the iris border. Elevation of IOP is evident in some females by 6 months of age. By 9 months of age, both sexes exhibit elevated IOP, with pressures higher in females (mean: 20.3 +/-79; 1.8 mmHg) compared to males (mean: 16.2 +/-79; 1.4 mmHg). Retinal histopathology reveals retinal ganglion cell, as well as GABAergic and cholinergic amacrine cell, loss. (Moon JI, et al., 2005). Two alleles contribute to the eye phenotype, Gpnmb^R150X and Tyrp1^isa; both are present in DBA/2J mice.
DBA/2J mice also show an extreme intolerance to alcohol and morphine. In 2002, Vance et al. reported that NK cells in DBA/2J exhibit the unique characteristic that they lack surface expression of CD94/NKG2A receptors. CD94/NKG2 receptors are normally expressed on the surface of most fetal NK cells. Expression of CD94/NKG2 is thought to play a role in self tolerance and the ability of NK cells to distinguish between MHC I^low and MHC I^high target cells. CD94 is the product of the mouse Klrd1 locus, on mouse Chromosome 6. A subsequent publication by Wilhelm and coworkers identified a deletion in the 3' end of the Klrd1 gene of DBA/2J mice. This ~2.4 kb deletion does not prevent transcription of the gene, but prevents translation and cell surface expression of the CD94 protein. Analysis of DNA samples held at The Jackson Laboratory (unpublished results) confirmed the presence of the deletion of Klrd1 in the DBA/2J strain. The deletion, which occurred sometime between 1984 and 1989, is homozygous within our colonies, making DBA/2J mice naturally CD94 deficient.
Strain Development
The DBA inbred strain is the oldest of all inbred strains of mice. Dr. CC Little began inbreeding in 1909 from a mouse colony segregating for coat color. During 1929 and 1930 crosses were made among substrains, and several new substrains were established including DBA/1 and DBA/2. DBA/1 and DBA/2 differ at a large number of loci (including the MHC H2 haplotype) which is most likely results from residual heterozygosity in the strain when the substrains were separated.

Related Disease (OMIM) Terms

Glaucoma-Related Pigment Dispersion Syndrome

Mammalian Phenotype Terms assigned by genotype

Gpnmb^R150X/Gpnmb^R150X
DBA/2J
vision/eye phenotype

abnormal iris pigmentation (J:54013)

pigment dispersion in the iris

pigmentation phenotype

abnormal iris pigmentation (J:54013)

pigment dispersion in the iris

Gpnmb^R150X/Gpnmb^R150X Tyrp1^isa/Tyrp1^isa
DBA/2J
vision/eye phenotype

abnormal iris pigment epithelium (J:54013)

atrophy

abnormal iris stroma morphology (J:54013)

atrophy

optic nerve atrophy (J:54013)

retinal ganglion cell degeneration (J:54013)

loss of retinal ganglion cells

pigmentation phenotype

abnormal iris pigment epithelium (J:54013)

atrophy

nervous system phenotype

optic nerve atrophy (J:54013)

retinal ganglion cell degeneration (J:54013)

loss of retinal ganglion cells

Tyrp1^isa/Tyrp1^isa
DBA/2J
vision/eye phenotype

abnormal iris stroma morphology (J:54013)

atrophy

Gene & Allele Details

Allele Symbol		Cdh23^ahl
Allele Name		age related hearing loss 1
Common Name(s)		Cdh23^753A; mdfw;
Strain of Origin		C57BL/6J
Gene Symbol and Name		Cdh23, cadherin 23 (otocadherin)
Chromosome		10
Gene Common Name(s)		4930542A03Rik; DFNB12; DKFZp434P2350; FLJ00233; FLJ36499; KIAA1774; KIAA1812; MGC102761; RIKEN cDNA 4930542A03 gene; USH1D; W; age related hearing loss 1; ahl; bob; bobby; bus; bustling; mdfw; modifier of deaf waddler; neuroscience mutagenesis facility, 112; neuroscience mutagenesis facility, 181; neuroscience mutagenesis facility, 252; nmf112; nmf181; nmf252; v; waltzer;
Molecular Note		Genetic complementation tests have shown allelism between the mdfw (modifier of deaf waddler) locus and the ahl locus. Further analysis has identified an association between ahl and a G to A transition at nucleotide position 753 of Cdh23. This hypomorphic allele causes in frame skipping of exon 7 and reduced message stability. Twenty-seven strains classified with ahl and carrying the 753A allele include: CD1, RBF/DnJ, PL/J, AKR/J, RF/J, BALB/cBy, A/WySnJ, P/J, SENCARA/PtJ, DBA/1J, ALS/LtJ, C58/J, C57BLKS/J, 129P1/ReJ, C57BR/cd, SKH2/J, BUB/Bn, MA/MyJ, LP/J, 129X1/SvJ, NOR/LtJ, A/J, C57BL/6, NOD/LyJ, DBA/2J, ALR/LtJ, C57L/J. Strains classified with ahl that DO NOT carry this mutation include: C3H/HeSnJ, I/LnJ,YBR/Ei, MRL/MpJ. [J:86905]

Allele Symbol		Gpnmb^R150X
Allele Name		iris pigment dispersion
Common Name(s)		Gpnmb^ipd;
Strain of Origin		DBA/2J
Gene Symbol and Name		Gpnmb, glycoprotein (transmembrane) nmb
Chromosome		6
Gene Common Name(s)		Dchil; HGFIN; NMB; Osteoactivin; dendritic cell associated heparan sulfate proteoglycans dependent integrin ligand; ipd; iris pigment dispersion;
General Note		The mouse strain DBA/2J develops glaucoma associated with iris stromal atrophy and iris pigment dispersion phneotypes. Genetic studies defined two separate loci that contribute to the overall phenotype in the DBA/2J mouse, ipd and isa. Either mutation in a homozygous state contributes to glaucoma, while mice homozygous for both mutations develop an earlier onset and more severe iris disease.
Molecular Note		The underlying mutation responsible for the phenotype in the iris pigment dispersion mouse was identified as a C to T substitution that resulted in a nonsense mutation, Arg150stop. [J:75398]

Allele Symbol		Hc⁰
Allele Name		deficient
Common Name(s)		C5-; C5-d; C5-def; C5-deficient; hc^o;
Gene Symbol and Name		Hc, hemolytic complement
Chromosome		2
Gene Common Name(s)		C5; C5a; CPAMD4; FLJ17816; FLJ17822; He; MGC142298; RGD1561905;
General Note		This is an allele characteristic of various inbred mouse strains including the following: A/HeJ, AKR/J, DBA/2J, NZB/B1NJ, SWR/J, B10.D2/oSnJ Hc was identified as a candidate gene for Abhr2 in a microarray analysis of lung mRNA from A/J, C3H/HeJ, and (A/J x C3H/HeJ)F1 x A/J backcross animals. Hc genotype shows statistically significant correlation to allergen-induced bronchial hyperresponsive phenotype. The A/J allele contains a 2 bp deletion resulting in deficient Hc mRNA and protein production and is associated with susceptibility to allergen-induced bronchial hyperresponsiveness. (J:108211)
Molecular Note		A 2 base "TA" deletion at positions 62 and 63 of an 83 base pair exon near the 5' end of the gene is found in the following mouse strains: A/HeJ, AKR/J, DBA/2J, NZB/B1NJ, SWR/J, B10.D2/oSnJ. The consequence of this deletion is the creation of a stop codon starting four bases after the deletion. A truncated product of 216 amino acids is predicted as a result although contradictory reports exist that a larger pro-C5 protein may be synthesized. Nevertheless, macrophages from mouse strains carrying this allele do not secrete complement 5. [J:23983]

Allele Symbol		Tyrp1^isa
Allele Name		iris stromal atrophy
Common Name(s)		isa;
Strain of Origin		DBA/2J
Gene Symbol and Name		Tyrp1, tyrosinase-related protein 1
Chromosome		4
Gene Common Name(s)		B; CAS2; CATB; GP75; TRP; TRP-1; TRP1; TYRP; Tyrp; b; b-PROTEIN; brown; iris stromal atrophy; isa; tyrosinase-related protein;
General Note		The mouse strain DBA/2J develops glaucoma associated with iris stromal atrophy and iris pigment dispersion phneotypes. Genetic studies defined two separate loci that contribute to the overall phenotype in the DBA/2J mouse, ipd and isa. Either mutation in a homozygous state contributes to glaucoma, while mice homozygous for both mutations develop an earlier onset and more severe iris disease.
Molecular Note		Expression of a BAC containing the wild type Tyrp1 gene rescues the phenotype of isa mice. The isa phenotype has been identified in numerous aged stocks carrying Tyrp1^b allele. It is therefore most probable, that the Tyrp1^b alleleis responsible for the isa phenotype. [J:75398]

Colony Maintenance

Diet Information	LabDiet® 5K54

Related Strains

DBA Strains

000670 DBA/1J

001140 DBA/1LacJ

001907 DBA/2BiJ

000052 DBA/2DeJ

000973 DBA/2HaSmnJ

002860 DBA/8BiDsmJ

View DBA Strains (6 strains)

Strains carrying Cdh23^ahl allele

001137 129P1/ReJ

000690 129P3/J

002065 129T2/SvEmsJ

000691 129X1/SvJ

000646 A/J

000647 A/WySnJ

003070 ALR/LtJ

003072 ALS/LtJ

004502 B6;AKR-Lxl2/J

001026 BALB/cByJ

000653 BUB/BnJ

005494 C3.129S1(B6)-Grm1^rcw/J

000664 C57BL/6J

004764 C57BL/6J-Cdh23^v-8J/J

003129 C57BL/6J-Epha4^rb-2J/J

004820 C57BL/6J-Kcne1^2J/J

004703 C57BL/6J-Nmf134/J

004811 C57BL/6J-nmf110/J

004812 C57BL/6J-nmf111/J

004747 C57BL/6J-nmf118/J

004656 C57BL/6J-nmf88/J

004391 C57BL/6J-Chr 13^A/J/NaJ

004385 C57BL/6J-Chr 7^A/J/NaJ

000662 C57BLKS/J

000667 C57BR/cdJ

000668 C57L/J

000669 C58/J

000657 CE/J

000670 DBA/1J

001140 DBA/1LacJ

007048 DBA/2J-Gpnmb⁺/SjJ

002106 KK/HlJ

000675 LG/J

000676 LP/J

000677 MA/MyJ

001976 NOD/ShiLtJ

002050 NOR/LtJ

000679 P/J

002747 SENCARB/PtJ

002335 SKH2/J

003392 STOCK Crb1^rd8/J

View Strains carrying Cdh23^ahl (41 strains)

Strains carrying Hc⁰ allele

000645 A/HeJ

000646 A/J

000647 A/WySnJ

000648 AKR/J

000460 B10.D2-Hc⁰ H2^d H2-T18^c/o2SnJ

000461 B10.D2-Hc⁰ H2^d H2-T18^c/oSnJ

000657 CE/J

007048 DBA/2J-Gpnmb⁺/SjJ

001800 FVB/NJ

001491 FVB/NMob

000674 I/LnJ

001303 NOD.CB17-Prkdc^scid/J

001976 NOD/ShiLtJ

000684 NZB/BlNJ

000682 RF/J

000688 ST/bJ

000689 SWR/J

View Strains carrying Hc⁰ (17 strains)

Strains carrying other alleles of Cdh23

008288 B6(Cg)-Cdh23^v-11J/J

002756 B6.CAST-Cdh23^Ahl+/Kjn

002432 B6J x B6.C-H2^bm1/ByJ-Cdh23^v-J/J

002552 C57BL/6J-Cdh23^v-2J/J

004764 C57BL/6J-Cdh23^v-8J/J

004819 C57BL/6J-Cdh23^v-9J/J

005016 CByJ;B6-Cdh23^v-10J/J

000275 V/LeJ

View Strains carrying other alleles of Cdh23 (8 strains)

Strains carrying other alleles of Gpnmb

007048 DBA/2J-Gpnmb⁺/SjJ

View Strains carrying other alleles of Gpnmb (1 strain)

Strains carrying other alleles of Hc

000470 AK.M-H2^m H2-T18^a/nSnJ

005308 B10.Cg-H2^d Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ

000463 B10.D2-Hc¹ H2^d H2-T18^c/nSnJ

003147 B10.D2-Hc¹ H2^d H2-T18^c/nSnJ-Tg(DO11.10)10Dlo/J

004306 NOD.CBALs-Hc¹/LtJ

View Strains carrying other alleles of Hc (5 strains)

Strains carrying other alleles of Tyrp1

000004 ABP/LeJ

000571 B6.Cg-Whrn^wi Tyrp1^b/+ +/J

000027 B6.D-Tyrp1^b m/J

000068 C57BL/6J-Tyrp1^b-J/J

000093 C57BL/6J-Tyrp1^b-cJ/J

003588 LT/SvEi

006252 LT/SvEiJ

000265 MY/HuLeJ

001045 SI/Col Tyrp1^b Dnahc11^iv/J

002142 STOCK 11R30m/J

000064 STOCK a Tyrp1^b Si^si/J

002238 STOCK a Tyrp1^b shmy/J

001432 STOCK a/a Tyrp1^b sks/Tyrp1^b +/J

000594 STOCK T(2;8)26H a/T(2;8)26H a Tyrp1⁺/Tyrp1^b/J

001101 STOCK T(3;4)5Rk Tyrp1^b/J

000274 TSJ/LeJ

View Strains carrying other alleles of Tyrp1 (16 strains)

Phenotypic Data

Body Weight Information - JAX^® Mice Strain DBA/2J (000671)
(This chart reflects the typical correlation between body weight and age for mice maintained in production colonies at The Jackson Laboratory.)
Mouse Phenome Database
Mouse Phenome Database - atherogenic diet
Mouse Phenome Database - body weight
Mouse Phenome Database - cardiovascular
Mouse Phenome Database - cholesterol
Mouse Phenome Database - disease susceptibility
Mouse Phenome Database - food and water intake
Mouse Phenome Database - hearing
Mouse Phenome Database - hematology
Mouse Phenome Database - hormones
Mouse Phenome Database / SNP Facility
Festing Inbred Strain Characteristics: DBA
NEW -- JAX^® Physiological Data Summary
NEW -- JAX^® Physiological Data Protocol

Additional Web Information

NEW -- JAX^® Physiological Data Protocol
NEW -- JAX^® Physiological Data Summary
Genetic Quality Control Annual Report
JAX Notes, April 1988; 433. H-2 Haplotypes of Mice from Jackson Laboratory Production Colonies.
JAX Notes, Fall 2003; 491. JAX West Expansion
JAX Notes, Fall 2004; 495. CD94 Deletion Verified in JAX® Mice Strain DBA/2J.
JAX Notes, Spring 1990; 441. Imperforate Vagina and Mucometra in Mice.
JAX Notes, Spring 2002; 485. Genes Implicated in a Mouse Model for Pigmentary Glaucoma.
JAX Notes, Spring 2003; 489. Malocclusion in the Laboratory Mouse.
JAX Notes, Summer 2003; 490. Hydrocephalus in Laboratory Mice.
JAX Notes, Winter 2006; 504. JAX® Mice: the Gold Standard Just Got Better.
National Center for Biotechnology Information / SNP Data

Animal Health Reports

Room Number AX3
Room Number AX9
Room Number MP14
Room Number WR3

Research Applications

This mouse can be used to support research in many areas including:

Cardiovascular Research
Diet-Induced Atherosclerosis (Relatively Resistant)

Developmental Biology Research
Lymphoid Tissue Defects (hematopoietic defects)

Neurobiology Research
Epilepsy (audiogenic seizures)
Vestibular and Hearing Defects (Age related hearing loss)

Research Tools
General Purpose
Immunology and Inflammation Research (specific complement deficiency) (C5 complement)

Sensorineural Research
Eye Defects (hereditary glaucoma)
Vestibular and Hearing Defects (Age related hearing loss)

Cdh23^ahl related

Neurobiology Research
Vestibular and Hearing Defects (Age related hearing loss)

Sensorineural Research
Vestibular and Hearing Defects (Age related hearing loss)

Hc⁰ related

Immunology and Inflammation Research
Immunodeficiency (specific complement deficiency)

Research Tools
Immunology and Inflammation Research (specific complement deficiency) (C5 complement)

References

Selected Reference(s)

Anderson MG; Smith RS; Hawes NL; Zabaleta A; Chang B; Wiggs JL; John SW. 2002. Mutations in genes encoding melanosomal proteins cause pigmentary glaucoma in DBA/2J mice. Nat Genet 30(1):81-5. [PubMed: 11743578] [J:75398]
Doering CH; Shire JG; Kessler S; Clayton RB. 1973. Genetic and biochemical studies of the adrenal lipid depletion phenotype in mice. Biochem Genet 8(1):101-11. [PubMed: 4348256] [J:5333]
Drake TA; Schadt E; Hannani K; Kabo JM; Krass K; Colinayo V; Greaser LE rd; Goldin J; Lusis AJ. 2001. Genetic loci determining bone density in mice with diet-induced atherosclerosis. Physiol Genomics 5(4):205-15. [PubMed: 11328966] [J:69682]
Kirk EA; Moe GL; Caldwell MT; Lernmark JA; Wilson DL; LeBoeuf RC. 1995. Hyper- and hypo-responsiveness to dietary fat and cholesterol among inbred mice: searching for level and variability genes. J Lipid Res 36(7):1522-32. [PubMed: 7595076] [J:28648]
Nishina PM; Wang J; Toyofuku W; Kuypers FA; Ishida BY; Paigen B. 1993. Atherosclerosis and plasma and liver lipids in nine inbred strains of mice. Lipids 28(7):599-605. [PubMed: 8355588] [J:13267]
Paigen B. 1995. Genetics of responsiveness to high-fat and high- cholesterol diets in the mouse. Am J Clin Nutr 62(2):458S-462S. [PubMed: 7625360] [J:28248]
Paigen B; Ishida BY; Verstuyft J; Winters RB; Albee D. 1990. Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice. Arteriosclerosis 10(2):316-23. [PubMed: 2317166] [J:22615]
Paigen B; Morrow A; Brandon C; Mitchell D; Holmes P. 1985. Variation in susceptibility to atherosclerosis among inbred strains of mice. Atherosclerosis 57(1):65-73. [PubMed: 3841001] [J:109950]

Additional References

Price and Supply Information

Strain Name:	DBA/2J
Stock Number:	000671

Price Details

IMPORTANT NOTE: Prices are based on shipping destination. The shipping destinations are:

USA, Canada and Mexico
International

*Pricing for Shipping Destination selected:

USA, Canada and Mexico

Price(s) in US dollars ($)
3 weeks	$18.80	Female
4 weeks	$18.80	Female
5 weeks	$18.80	Female
6 weeks	$20.80	Female
7 weeks	$24.70	Female
8 weeks	$24.70	Female
9 weeks	$24.70	Female
10 weeks	$28.70	Female
11 weeks	$28.70	Female
12 weeks	$28.70	Female
13 weeks	$29.95	Female
14 weeks	$31.20	Female
15 weeks	$32.45	Female
3 weeks	$17.30	Male
4 weeks	$17.30	Male
5 weeks	$17.30	Male
6 weeks	$19.30	Male
7 weeks	$23.20	Male
8 weeks	$23.20	Male
9 weeks	$25.20	Male
10 weeks	$27.20	Male
11 weeks	$27.20	Male
12 weeks	$27.20	Male
13 weeks	$28.45	Male
14 weeks	$29.70	Male
15 weeks	$30.95	Male

Supply Details

Standard Supply	JAX Ready Strain^® (Level 1). Most popular strains. Readily available in any quantity you need.
Supply Notes	Histology and Tissue Collection Services are available for all JAX^® Mice strains. For more information, please contact Customer Service at orderquest@jax.org or 1-800-422-6423. Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available. Strains that must be genotyped are not available until five to seven weeks of age. This strain is available from both the Bar Harbor and California facilities. This strain is available from some international Charles River Laboratories (CRL) breeding facilities in Japan and/or Europe. For more information, see the Worldwide Distributor List for JAX^® Mice. Timed pregnant females are available from the Bar Harbor facility. Genomic DNA is available for this strain from the Mouse DNA Resource.
Licensing	See General Terms and Conditions below

General Terms and Conditions

View JAX^® Mice & Services Conditions of Use.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Go to JAX^® Mice Query Form

000670	DBA/1J
001140	DBA/1LacJ
001907	DBA/2BiJ
000052	DBA/2DeJ
000973	DBA/2HaSmnJ
002860	DBA/8BiDsmJ

001137	129P1/ReJ
000690	129P3/J
002065	129T2/SvEmsJ
000691	129X1/SvJ
000646	A/J
000647	A/WySnJ
003070	ALR/LtJ
003072	ALS/LtJ
004502	B6;AKR-Lxl2/J
001026	BALB/cByJ
000653	BUB/BnJ
005494	C3.129S1(B6)-Grm1^rcw/J
000664	C57BL/6J
004764	C57BL/6J-Cdh23^v-8J/J
003129	C57BL/6J-Epha4^rb-2J/J
004820	C57BL/6J-Kcne1^2J/J
004703	C57BL/6J-Nmf134/J
004811	C57BL/6J-nmf110/J
004812	C57BL/6J-nmf111/J
004747	C57BL/6J-nmf118/J
004656	C57BL/6J-nmf88/J
004391	C57BL/6J-Chr 13^A/J/NaJ
004385	C57BL/6J-Chr 7^A/J/NaJ
000662	C57BLKS/J
000667	C57BR/cdJ
000668	C57L/J
000669	C58/J
000657	CE/J
000670	DBA/1J
001140	DBA/1LacJ
007048	DBA/2J-Gpnmb⁺/SjJ
002106	KK/HlJ
000675	LG/J
000676	LP/J
000677	MA/MyJ
001976	NOD/ShiLtJ
002050	NOR/LtJ
000679	P/J
002747	SENCARB/PtJ
002335	SKH2/J
003392	STOCK Crb1^rd8/J

000645	A/HeJ
000646	A/J
000647	A/WySnJ
000648	AKR/J
000460	B10.D2-Hc⁰ H2^d H2-T18^c/o2SnJ
000461	B10.D2-Hc⁰ H2^d H2-T18^c/oSnJ
000657	CE/J
007048	DBA/2J-Gpnmb⁺/SjJ
001800	FVB/NJ
001491	FVB/NMob
000674	I/LnJ
001303	NOD.CB17-Prkdc^scid/J
001976	NOD/ShiLtJ
000684	NZB/BlNJ
000682	RF/J
000688	ST/bJ
000689	SWR/J

008288	B6(Cg)-Cdh23^v-11J/J
002756	B6.CAST-Cdh23^Ahl+/Kjn
002432	B6J x B6.C-H2^bm1/ByJ-Cdh23^v-J/J
002552	C57BL/6J-Cdh23^v-2J/J
004764	C57BL/6J-Cdh23^v-8J/J
004819	C57BL/6J-Cdh23^v-9J/J
005016	CByJ;B6-Cdh23^v-10J/J
000275	V/LeJ

000470	AK.M-H2^m H2-T18^a/nSnJ
005308	B10.Cg-H2^d Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
000463	B10.D2-Hc¹ H2^d H2-T18^c/nSnJ
003147	B10.D2-Hc¹ H2^d H2-T18^c/nSnJ-Tg(DO11.10)10Dlo/J
004306	NOD.CBALs-Hc¹/LtJ

000004	ABP/LeJ
000571	B6.Cg-Whrn^wi Tyrp1^b/+ +/J
000027	B6.D-Tyrp1^b m/J
000068	C57BL/6J-Tyrp1^b-J/J
000093	C57BL/6J-Tyrp1^b-cJ/J
003588	LT/SvEi
006252	LT/SvEiJ
000265	MY/HuLeJ
001045	SI/Col Tyrp1^b Dnahc11^iv/J
002142	STOCK 11R30m/J
000064	STOCK a Tyrp1^b Si^si/J
002238	STOCK a Tyrp1^b shmy/J
001432	STOCK a/a Tyrp1^b sks/Tyrp1^b +/J
000594	STOCK T(2;8)26H a/T(2;8)26H a Tyrp1⁺/Tyrp1^b/J
001101	STOCK T(3;4)5Rk Tyrp1^b/J
000274	TSJ/LeJ

Strain Name:

DBA/2J

Stock Number:

000671

Availability:

Level 1

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Strain Details

GpnmbR150X/GpnmbR150X

GpnmbR150X/GpnmbR150X Tyrp1isa/Tyrp1isa

Tyrp1isa/Tyrp1isa

Gene & Allele Details

Colony Maintenance

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*Pricing for Shipping Destination selected:

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The Jackson Laboratory's Genotype Promise

Gpnmb^R150X/Gpnmb^R150X

Gpnmb^R150X/Gpnmb^R150X Tyrp1^isa/Tyrp1^isa

Tyrp1^isa/Tyrp1^isa