Description

Strain Information

Former Names I/J    (Changed: 31-AUG-10 ) Type Inbred Strain; Additional information on Inbred Strains. Visit our online Nomenclature tutorial. Mating System Sibling x Sibling         (Female x Male)   01-MAR-06 Species laboratory mouse H2 Haplotype j Generation [F143+10p]+F4 (06-MAR-13) Generation Definitions

Appearance
pink-eyed dilute brown, piebald (spotted)
Related Genotype: a/a Tyrp1^b/Tyrp1^b Oca2^p/Oca2^p Myo5a^d/Myo5a^d Ednrb^s/Ednrb^s

Description
I/LnJ mice were originally derived by Dr. LC Strong in 1926 from an unpedigreed stock of mice. A high proportion of mice from this strain lack a corpus callosum. This absence is associated with slow growth of the medial septum subadjacent to the cavum septi. I/LnJ mice are resistant to mmtv induced mammary tumor development and generate neutralizing antibodies to mmtv and MuLv virions that effectively block viral transmission. Due to a frameshift mutation in alpha 1 phosphorylase kinase these mice have increased glycogen content in resting skeletal muscle. The reproductive performance of I/LnJ mice is very poor. Further analysis indicates that oocytes from I/LnJ mice display retarded kinetics of meiotic maturation and a high frequency of metaphase I arrest. Some oocytes fail to resume meiosis. Oocytes have many very small centrosomes with an absence of microtubules. I/LnJ mice, in addition to carrying several other coat color alleles, are homozygous for the piebald mutation (Ednrb^s). The piebald spontaneous mutation is the result of a mutation in the endothelin receptor type B gene, Ednrb. Mice show irregular white spotting, the amount of which is greatly influenced by minor modifying genes. They also have dark eyes. The white areas of the coat are completely lacking in neural crest-derived melanocytes, and there is a reduction in the number of melanocytes in the choroid layer of the eye.

Related Strains

Strains carrying   Ahr^d allele

000690	129P3/J
000648	AKR/J
008599	B6.Cg-Cyp1a2/Cyp1a1tm2Dwn Ahrd Tg(CYP1A1,CYP1A2)1Dwn/DwnJ
002921	B6.D2N-Ahrd/J
000652	BDP/J
000928	CAST/EiJ
000671	DBA/2J
000675	LG/J
000676	LP/J
000684	NZB/BlNJ
000726	RBF/DnJ
000682	RF/J
000686	SJL/J
000688	ST/bJ
000689	SWR/J
000693	WC/ReJ KitlSl/J
000933	YBR/EiJ

View Strains carrying   Ahr^d     (17 strains)

Strains carrying   Ednrb^s allele

000577	B6 x STOCK a Oca2p Hps5ru2 Ednrbs/J
003720	JF1/Ms
000676	LP/J
000308	SSL/LeJ
000275	V/LeJ

View Strains carrying   Ednrb^s     (5 strains)

Strains carrying   Hc⁰ allele

000645	A/HeJ
000646	A/J
000647	A/WySnJ
000648	AKR/J
000460	B10.D2-Hc0 H2d H2-T18c/o2SnJ
000461	B10.D2-Hc0 H2d H2-T18c/oSnJ
000657	CE/J
000671	DBA/2J
007048	DBA/2J-Gpnmb+/SjJ
001800	FVB/NJ
001491	FVB/NMob
001303	NOD.CB17-Prkdcscid/J
001976	NOD/ShiLtJ
000684	NZB/BlNJ
000682	RF/J
000688	ST/bJ
000689	SWR/J

View Strains carrying   Hc⁰     (17 strains)

Strains carrying   Myo5a^d allele

001005	AKXD1/TyJ
001003	AKXD11/TyJ
000765	AKXD13/TyJ
000779	AKXD14/TyJ
000954	AKXD15/TyJ
001093	AKXD18/TyJ
000776	AKXD2/TyJ
001062	AKXD21/TyJ
000947	AKXD22/TyJ
000949	AKXD25/TyJ
000764	AKXD27/TyJ
000959	AKXD3/TyJ
000285	B6.Cg-Rorasg + +/+ Myo5ad Bmp5se/J
012889	B6N;TKDU-Myo5ad Cacna2d2du/J
000652	BDP/J
000036	BXD1/TyJ
000013	BXD16/TyJ
000015	BXD18/TyJ
000010	BXD19/TyJ
000077	BXD21/TyJ
000043	BXD22/TyJ
000081	BXD25/TyJ
000029	BXD29-Tlr4lps-2J/J
010981	BXD29/Ty
000037	BXD5/TyJ
000007	BXD6/TyJ
000084	BXD8/TyJ
000105	BXD9/TyJ
000284	CWD/LeJ
000670	DBA/1J
000671	DBA/2J
000963	DBA/2J-Myo5ad+17J/Myo5ad/J
000964	DBA/2J-Myo5ad+18J/Myo5ad/J
000067	DBA/2J-Myo5ad+2J/Myo5ad/J
000673	HRS/J
001850	MEV-Q/TyJ
001855	MEV-V/TyJ
003345	MEV/2Ty-Emv64/J
000679	P/J
000644	SEA/GnJ
000390	STOCK Myo5ad Ds/J
000994	STOCK a Myo5ad Mregdsu/J
000286	STOCK a/a Myo5ad fd/+ +/J

View Strains carrying   Myo5a^d     (43 strains)

Strains carrying other alleles of Ahr

000645	A/HeJ
000646	A/J
002920	B6(D2N).Spretus-Ahrb-3/J
006203	B6.129(FVB)-Ahrtm3.1Bra/J
002831	B6.129-Ahrtm1Bra/J
000130	B6.C-H17c/(HW14)ByJ
000136	B6.C-H34c/(HW22)ByJ
000370	B6.C-H38c/(HW119)ByJ
002727	B6;129-Ahrtm1Bra/J
001026	BALB/cByJ
000653	BUB/BnJ
000659	C3H/HeJ
000663	C57BL/6By
001139	C57BL/6ByJ
000664	C57BL/6J
000662	C57BLKS/J
000667	C57BR/cdJ
000668	C57L/J
000669	C58/J
000926	CAROLI/EiJ
000656	CBA/J
000657	CE/J
000351	CXB1/ByJ
000352	CXB2/ByJ
000353	CXB3/ByJ
000354	CXB4/ByJ
000355	CXB5/ByJ
000356	CXB6/ByJ
000357	CXB7/ByJ
002937	D2.B6-Ahrb-1/J
000673	HRS/J
000677	MA/MyJ
000550	MOLF/EiJ
000679	P/J
000930	PERA/EiJ
000644	SEA/GnJ
000280	SF/CamEiJ
001146	SPRET/EiJ

View Strains carrying other alleles of Ahr     (38 strains)

Strains carrying other alleles of Ednrb

011080	B6;129-Ednrbtm1.1Nat/J
003295	B6;129-Ednrbtm1Ywa/J
000308	SSL/LeJ
004711	STOCK Ednrbs-52Pub
009063	STOCK Ednrbtm1Nrd/J

View Strains carrying other alleles of Ednrb     (5 strains)

Strains carrying other alleles of Hc

000470	AK.M-H2m H2-T18a/nSnJ
005308	B10.Cg-H2d Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
000463	B10.D2-Hc1 H2d H2-T18c/nSnJ
003147	B10.D2-Hc1 H2d H2-T18c/nSnJ-Tg(DO11.10)10Dlo/J
004306	NOD.CBALs-Hc1/LtJ

View Strains carrying other alleles of Hc     (5 strains)

Strains carrying other alleles of Myo5a

005012	A.B6 Tyr+-Myo5ad-l31J/J
001013	B10.D2/nSnJ-Myo5ad-n/J
000502	B6 x B6CBCa Aw-J/A-Myo5aflr Gnb5flr/J
000963	DBA/2J-Myo5ad+17J/Myo5ad/J
000964	DBA/2J-Myo5ad+18J/Myo5ad/J
000067	DBA/2J-Myo5ad+2J/Myo5ad/J
000253	DLS/LeJ

View Strains carrying other alleles of Myo5a     (7 strains)

Additional Web Information

JAX^® NOTES, April 1988; 433. H-2 Haplotypes of Mice from Jackson Laboratory Production Colonies.

Phenotype

Phenotype Information

View Phenotypic Data

Phenotypic Data

Mouse Phenome Database
Festing Inbred Strain Characteristics: I

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI

- Model with phenotypic similarity to human disease where etiologies involve orthologs. Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).

Glycogen Storage Disease, Type Ixd; GSD9D

- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested. Abcd Syndrome; ABCDS   (EDNRB) Complement Component 5 Deficiency; C5D   (C5) Griscelli Syndrome, Type 1; GS1   (MYO5A) Hirschsprung Disease, Susceptibility to, 2; HSCR2   (EDNRB) Waardenburg Syndrome, Type 4A; WS4A   (EDNRB)

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI

      assigned by genotype

Phka1^I/FnLn/Phka1^I/FnLn

        I/FnLn

• homeostasis/metabolism phenotype
• increased skeletal muscle glycogen level
  • the glycogen content of resting skeletal muscle is two to three fold higher than that in C57BL/FnLn controls, with a mean of 11.5mg/g tissue versus 4.4mg/g, and epinephrine does not induce phosphorylase kinase activity   (MGI Ref ID J:5156)
• muscle phenotype
• increased skeletal muscle glycogen level
  • the glycogen content of resting skeletal muscle is two to three fold higher than that in C57BL/FnLn controls, with a mean of 11.5mg/g tissue versus 4.4mg/g, and epinephrine does not induce phosphorylase kinase activity   (MGI Ref ID J:5156)

Phka1^I/FnLn/Y

        I/FnLn

• homeostasis/metabolism phenotype
• increased skeletal muscle glycogen level
  • the glycogen content of resting skeletal muscle in hemizygous males is three fold higher than that in C57BL/FnLn controls, with a mean of 13.1mg/g tissue versus 4mg/g   (MGI Ref ID J:5156)
• muscle phenotype
• increased skeletal muscle glycogen level
  • the glycogen content of resting skeletal muscle in hemizygous males is three fold higher than that in C57BL/FnLn controls, with a mean of 13.1mg/g tissue versus 4mg/g   (MGI Ref ID J:5156)

vic1/vic1

        I/LnJ

• immune system phenotype
• decreased susceptibility to viral infection   (MGI Ref ID J:60602)
  • although MMTV and MuLV infection can occur, MMTV transmission and mammary tumor induction are blocked and MuLV transmission and virally induced disease are blocked, and these responses are mediated by anti-virion antibodies, require gamma interferon, cytotoxic immune responses, but not interleukin 12   (MGI Ref ID J:163153)
• tumorigenesis
• decreased incidence of induced tumors   (MGI Ref ID J:60602)
  • mammary glands become infected with MMTV but at 1.5 years zero of 24 infected females develop tumors   (MGI Ref ID J:81554)

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Neurobiology Research
Angelman syndrome
Hearing Defects
      Age related hearing loss, control
Neurodevelopmental Defects
      acallosal

Reproductive Biology Research
Developmental Defects Affecting Gonads
Fertility Defects

Sensorineural Research
Hearing Defects
      Age related hearing loss, control

Ahr^d related

Metabolism Research

Research Tools
Toxicology Research

Ednrb^s related

Dermatology Research
Color and White Spotting Defects

Developmental Biology Research
Neural Crest Defects
Neurodevelopmental Defects

Mouse/Human Gene Homologs
Hirschsprung disease

Neurobiology Research
Hearing Defects
Neurodevelopmental Defects
Receptor Defects

Sensorineural Research
Hearing Defects

Hc⁰ related

Immunology, Inflammation and Autoimmunity Research
Immunodeficiency
      specific complement deficiency

Research Tools
Immunology and Inflammation Research
      specific complement deficiency, C5 complement

Myo5a^d related

Dermatology Research
Color and White Spotting Defects

Mouse/Human Gene Homologs
Griscelli Syndrome

vic1 related

Cancer Research

Immunology, Inflammation and Autoimmunity Research

Virology Research

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol		Ahrd
Allele Name		d variant
Allele Type		Not Applicable
Common Name(s)		Ahd; Ahk; AhRd; Ahhn; ah; in;
Gene Symbol and Name		Ahr, aryl-hydrocarbon receptor
Chromosome		12
Gene Common Name(s)		Ah; Ahh; Ahre; In; aromatic hydrocarbon responsiveness; aryl hydrocarbon hydroxylase; bHLHe76; dioxin receptor; inflammatory reactivity;
General Note		Compared with Ahrd/Ahrd mice, Ahrb/Ahrb individuals have a high inflammatory response to cutaneous application of dimethylbenzanthracene; a high susceptibility to methylcholanthrene- and benzopyrene-induced subcutaneous sarcomas and methylcholanthrene-induced lung tumors; an increased resistance to zoxazolamine-induced paralysis, lindane toxicity, and benzo[a]pyrene-induced aplastic anemia and leukemia; a high susceptibility to acetaminophen-induced hepatic necrosis and cataract formation; and an increased susceptibility to polycyclic hydrocarbon-induced birth defects, stillbirths, resorptions, decreased body weight, ovarian primordial oocyte depletion, and spermatozoal aberrations (J:5822). The Ahrballele is associated with increases in numerous metabolites of chemical carcinogens binding to DNA nucleotides (J:12156). The effectiveness of several mutagens for Salmonella in vitro is enhanced by presence of a liver fraction from Ahrb/Ahrb> mice treated with polycyclic hydrocarbons, but not from similarly treated Ahrd/Ahr mice (J:5564). In contrast, oral doses of benzopyrene cause a high rate of leukemia in Ahrd/Ahrd but not in Ahrd/Ahrd mice, probably because the carcinogenic metabolites produced in responsive Ahrb/Ahrd mice are rapidly degraded in the intestine and excreted in the feces (J:6074). Strain of origin - this allele was found in DBA/2J, AKR/J, 129, SWR, RF, NZB strains
Molecular Note		This allele encodes a 104 kDa receptor that is stabilized by molybdate and has an affinity for ligand 10-100 fold lower than that of the receptor produced by the C57BL/6J allele. PCR sequencing of cDNA revealed ten nucleotide differences between the coding sequences of the DBA/2J and C57BL/6J receptors. Five of the ten differences would cause amino acid changes. One of these, an apparent T to C transition replaces the opal termination codon in the C57BL/6J allele with an arginine codon in the DBA/2J allele. This change would extend translation of the DBA/2J mRNA by 43 amino acids, accounting for the larger size of the peptide produced by this allele (104 kDa vs 95 kDa for the C57BL/6J allele). A second T to C transition changes a leucine codon in the C57BL/6J allele to a proline codon in the DBA/2J allele, and would likely change secondary structure of the peptide and thus ligand affinity. [MGI Ref ID J:15153] [MGI Ref ID J:17460] [MGI Ref ID J:22144]
Allele Symbol		Ednrbs
Allele Name		piebald
Allele Type		Spontaneous
Common Name(s)		pied spotting; s;
Strain of Origin		old mutant of the mouse fancy
Gene Symbol and Name		Ednrb, endothelin receptor type B
Chromosome		14
Gene Common Name(s)		ABCDS; AU022549; ET-B; ET-BR; ETB; ETBR; ETR-b; ETRB; Ednra; HSCR; HSCR2; Sox10m1; WS4A; expressed sequence AU022549; piebald; s;
General Note		Also called piebald spotting. This is a very old mutation of the mouse fancy, and was described in the scientific literature as early as 1920 (J23183). Some piebalds in existing stocks may be of independent origin. The white areas of the coat are completely lacking in melanocytes, and there is a reduction in the number of melanocytes in the choroid layer of the eye (J:15014, J:12970). There may also be defects in the structure of the iris, suggesting that pigment cells make some structural or inductive contribution to normal development (J:13123).
Molecular Note		This mutation is allelic to a targeted mutation for this gene. Homozygous mice produce approximately 25% of the normal levels of transcript from this allele. RT-PCR analysis demonstrated that no alterations in the coding sequence would result in any alteration of the amino acid sequence. A 5.5 kb retrotransposon-like element is found in intron 1. About 75% of the mRNA produced is an aberrant 6.5 kb form lacking exons 2-6 but containing exon 1. The remaining 25% of the mRNA formed is of normal, 4.4 kb, size. [MGI Ref ID J:110573] [MGI Ref ID J:22206] [MGI Ref ID J:56133]
Allele Symbol		Hc0
Allele Name		deficient
Allele Type		Spontaneous
Common Name(s)		C5-; C5-d; C5-def; C5-deficient; hco;
Strain of Origin		multiple strains
Gene Symbol and Name		Hc, hemolytic complement
Chromosome		2
Gene Common Name(s)		C5; C5a; C5b; CPAMD4; He; RGD1561905;
General Note		This is an allele characteristic of various inbred mouse strains including the following: A/HeJ, AKR/J, DBA/2J, NZB/B1NJ, SWR/J, B10.D2/oSnJ Hc was identified as a candidate gene for Abhr2 in a microarray analysis of lung mRNA from A/J, C3H/HeJ, and (A/J x C3H/HeJ)F1 x A/J backcross animals. Hc genotype shows statistically significant correlation to allergen-induced bronchial hyperresponsive phenotype. The A/J allele contains a 2 bp deletion resulting in deficient Hc mRNA and protein production and is associated with susceptibility to allergen-induced bronchial hyperresponsiveness. (J:108211)
Molecular Note		A 2 base "TA" deletion at positions 62 and 63 of an 83 base pair exon near the 5' end of the gene is found in the following mouse strains: A/HeJ, AKR/J, DBA/2J, NZB/B1NJ, SWR/J, B10.D2/oSnJ. The consequence of this deletion is the creation of a stop codon starting four bases after the deletion. A truncated product of 216 amino acids is predicted as a result although contradictory reports exist that a larger pro-C5 protein may be synthesized. Nevertheless, macrophages from mouse strains carrying this allele do not secrete complement 5. [MGI Ref ID J:23983] [MGI Ref ID J:5016]
Allele Symbol		Myo5ad
Allele Name		dilute
Allele Type		Spontaneous
Common Name(s)		Maltese dilution; blue dilution; d; dv;
Strain of Origin		old mutant of the mouse fancy
Gene Symbol and Name		Myo5a, myosin VA
Chromosome		9
Gene Common Name(s)		9630007J19Rik; AI413174; AI661011; D; Dbv; Dop; GS1; MVa; MYH12; MYO5; MYR12; Myo5; MyoVA; RIKEN cDNA 9630007J19 gene; d; dilute; expressed sequence AI413174; expressed sequence AI661011; flail; flailer; flr; myosin V; nmf244;
Molecular Note		This mutation is the result of the integration of ecotropic murine leukemia virus Emv-3 into a noncoding region of the Myo5ad gene. Reversions of Myo5ad to wild-type are caused by excision of the virus leaving exactly one long terminal repeat in place. [MGI Ref ID J:6587] [MGI Ref ID J:7092] [MGI Ref ID J:7751]
Allele Symbol		Phka1I/FnLn
Allele Name		I/FnLn
Allele Type		Spontaneous
Strain of Origin		I/FnLn
Gene Symbol and Name		Phka1, phosphorylase kinase alpha 1
Chromosome		X
Gene Common Name(s)		9830108K24Rik; PHKA; Pcyt1b; Phka; RIKEN cDNA 9830108K24 gene; phosphorylase kinase alpha;
Molecular Note		An insertion of a T residue after codon 429 results in a frameshift and premature termination 17 codons downstream which is only approximately one third of the normal protein length. Northern blot analysis reveals a great reduction of this transcript inmuscle extracts. [MGI Ref ID J:15833]
Allele Symbol		vic1
Allele Name		virus infectivity controller 1
Allele Type		Spontaneous
Strain of Origin		I/St
Gene Symbol and Name		vic1, virus infectivity controller 1
Chromosome		17

Genotyping

Genotyping Information

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Albertini DF; Eppig JJ. 1995. Unusual cytoskeletal and chromatin configurations in mouse oocytes that are atypical in meiotic progression. Dev Genet 16(1):13-9. [PubMed: 7758242]  [MGI Ref ID J:109918]

Bender PK; Lalley PA. 1989. I/Lyn mouse phosphorylase kinase deficiency: mutation disrupts expression of the alpha/alpha'-subunit mRNAs. Proc Natl Acad Sci U S A 86(24):9996-10000. [PubMed: 2602386]  [MGI Ref ID J:10186]

Case LK; Petell L; Yurkovetskiy L; Purdy A; Savage KJ; Golovkina TV. 2008. Replication of beta- and gammaretroviruses is restricted in I/LnJ mice via the same genetic mechanism. J Virol 82(3):1438-47. [PubMed: 18057254]  [MGI Ref ID J:163153]

Case LK; Purdy A; Golovkina TV. 2005. Molecular and cellular basis of the retrovirus resistance in I/LnJ mice. J Immunol 175(11):7543-9. [PubMed: 16301663]  [MGI Ref ID J:122155]

Hosoda K; Hammer RE; Richardson JA; Baynash AG; Cheung JC; Giaid A; Yanagisawa M. 1994. Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice. Cell 79(7):1267-76. [PubMed: 8001159]  [MGI Ref ID J:22206]

Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11. [PubMed: 15081119]  [MGI Ref ID J:89298]

Wahlsten D; Bulman-Fleming B. 1994. Retarded growth of the medial septum: a major gene effect in acallosal mice. Brain Res Dev Brain Res 77(2):203-14. [PubMed: 8174229]  [MGI Ref ID J:16942]

Wahlsten D; Schalomon PM. 1994. A new hybrid mouse model for agenesis of the corpus callosum. Behav Brain Res 64(1-2):111-7. [PubMed: 7840877]  [MGI Ref ID J:21337]

Additional References

Baynash AG; Hosoda K; Giaid A; Richardson JA; Emoto N; Hammer RE; Yanagisawa M. 1994. Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons. Cell 79(7):1277-85. [PubMed: 8001160]  [MGI Ref ID J:22207]

Golovkina TV. 2000. A novel mechanism of resistance to mouse mammary tumor virus infection. J Virol 74(6):2752-9. [PubMed: 10684291]  [MGI Ref ID J:60602]

International Nomenclature Committee. 1952. COMMITTEE on Standardized Nomenclature for Inbred Strains of Mice Cancer Res 12(8):602-13. [PubMed: 14945054]  [MGI Ref ID J:166288]

Lyon JB Jr. 1970. The X-chromosome and the enzymes controlling muscle glycogen: phosphorylase kinase. Biochem Genet 4(1):169-85. [PubMed: 5444100]  [MGI Ref ID J:5156]

Poland A; Glover E. 1990. Characterization and strain distribution pattern of the murine Ah receptor specified by the Ahd and Ahb-3 alleles. Mol Pharmacol 38(3):306-12. [PubMed: 2169579]  [MGI Ref ID J:34840]

Purdy A; Case L; Duvall M; Overstrom-Coleman M; Monnier N; Chervonsky A; Golovkina T. 2003. Unique Resistance of I/LnJ Mice to a Retrovirus Is Due to Sustained Interferon gamma-dependent Production of Virus-neutralizing Antibodies. J Exp Med 197(2):233-43. [PubMed: 12538662]  [MGI Ref ID J:81554]

Schneider A; Davidson JJ; Wullrich A; Kilimann MW. 1993. Phosphorylase kinase deficiency in I-strain mice is associated with a frameshift mutation in the alpha subunit muscle isoform. Nat Genet 5(4):381-5. [PubMed: 8298647]  [MGI Ref ID J:15833]

Wahlsten D; Ozaki HS; Livy D. 1992. Deficient corpus callosum in hybrids between ddN and three other abnormal mouse strains. Neurosci Lett 136(1):99-101. [PubMed: 1635672]  [MGI Ref ID J:2581]

Ahr^d related

Benedict WF; Considine N; Nebert DW. 1973. Genetic differences in aryl hydrocarbon hydroxylase induction and benzo(a)pyrene-produced tumorigenesis in the mouse. Mol Pharmacol 9(2):266-77. [PubMed: 4123113]  [MGI Ref ID J:84312]

Boobis AR; Nebert DW. 1976. Genetic differences in the metabolism of carcinogens and in the binding of benzo (a) pyrene metabolites to DNA. Adv Enzyme Regul 15:339-62. [PubMed: 1030186]  [MGI Ref ID J:12156]

Castro DJ; Lohr CV; Fischer KA; Pereira CB; Williams DE. 2008. Lymphoma and lung cancer in offspring born to pregnant mice dosed with dibenzo[a,l]pyrene: the importance of in utero vs. lactational exposure. Toxicol Appl Pharmacol 233(3):454-8. [PubMed: 18848954]  [MGI Ref ID J:143604]

Chang C; Smith DR; Prasad VS; Sidman CL; Nebert DW; Puga A. 1993. Ten nucleotide differences, five of which cause amino acid changes, are associated with the Ah receptor locus polymorphism of C57BL/6 and DBA/2 mice. Pharmacogenetics 3(6):312-21. [PubMed: 8148872]  [MGI Ref ID J:17460]

Curran CP; Miller KA; Dalton TP; Vorhees CV; Miller ML; Shertzer HG; Nebert DW. 2006. Genetic differences in lethality of newborn mice treated in utero with coplanar versus non-coplanar hexabromobiphenyl. Toxicol Sci 89(2):454-64. [PubMed: 16291824]  [MGI Ref ID J:113285]

Felton JS; Nebert DW. 1975. Mutagenesis of certain activated carcinogens in vitro associated with genetically mediated increases in monooxygenase activity and cytochrome P 1-450. J Biol Chem 250(17):6769-78. [PubMed: 808546]  [MGI Ref ID J:5564]

Gielen JE; Goujon FM; Nebert DW. 1972. Genetic regulation of aryl hydrocarbon hydroxylase induction. II. Simple Mendelian expression in mouse tissues in vivo. J Biol Chem 247(4):1125-37. [PubMed: 4110756]  [MGI Ref ID J:84250]

Goujon FM; Nebert DW; Gielen JE. 1972. Genetic expression of aryl hydrocarbon hydroxylase induction. IV. Interaction of various compounds with different forms of cytochrome P-450 and the effect on benzo(a)pyrene metabolism in vitro. Mol Pharmacol 8(6):667-80. [PubMed: 4118365]  [MGI Ref ID J:84252]

Harper PA; Golas CL; Okey AB. 1991. Ah receptor in mice genetically nonresponsive for cytochrome P4501A1 induction: cytosolic Ah receptor, transformation to the nuclear binding state, and induction of aryl hydrocarbon hydroxylase by halogenated and nonhalogenated aromatic hydrocarbons in embryonic tissues and cells. Mol Pharmacol 40(5):818-26. [PubMed: 1658612]  [MGI Ref ID J:2134]

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Russell ES. 1946. A Quantitative Histological Study of the Pigment Found in the Coat-Color Mutants of the House Mouse. I. Variable Attributes of the Pigment Granules. Genetics 31(3):327-46. [PubMed: 17247200]  [MGI Ref ID J:148463]

Russell ES. 1949. A Quantitative Histological Study of the Pigment Found in the Coat-Color Mutants of the House Mouse. IV. the Nature of the Effects of Genic Substitution in Five Major Allelic Series. Genetics 34(2):146-66. [PubMed: 17247308]  [MGI Ref ID J:12958]

Sweet HO. 1983. Dilute suppressor, a new suppressor gene in the house mouse. J Hered 74(4):305-6. [PubMed: 6886377]  [MGI Ref ID J:7171]

Yoshimura A; Fujii R; Watanabe Y; Okabe S; Fukui K; Takumi T. 2006. Myosin-Va facilitates the accumulation of mRNA/protein complex in dendritic spines. Curr Biol 16(23):2345-51. [PubMed: 17141617]  [MGI Ref ID J:117928]

Phka1^I/FnLn related

LYON JB Jr; PORTER J. 1963. The relation of phosphorylase to glycogenolysis in skeletal muscle and heart of mice. J Biol Chem 238:1-11. [PubMed: 13931951]  [MGI Ref ID J:37921]

Lyon JB Jr. 1970. The X-chromosome and the enzymes controlling muscle glycogen: phosphorylase kinase. Biochem Genet 4(1):169-85. [PubMed: 5444100]  [MGI Ref ID J:5156]

Lyon JB Jr; Porter J; Robertson M. 1967. Phosphorylase b kinase inheritance in mice. Science 155(769):1550-1. [PubMed: 6020474]  [MGI Ref ID J:163154]

Schneider A; Davidson JJ; Wullrich A; Kilimann MW. 1993. Phosphorylase kinase deficiency in I-strain mice is associated with a frameshift mutation in the alpha subunit muscle isoform. Nat Genet 5(4):381-5. [PubMed: 8298647]  [MGI Ref ID J:15833]

Wehner M; Clemens PR; Engel AG; Kilimann MW. 1994. Human muscle glycogenosis due to phosphorylase kinase deficiency associated with a nonsense mutation in the muscle isoform of the alpha subunit. Hum Mol Genet 3(11):1983-7. [PubMed: 7874115]  [MGI Ref ID J:42850]

vic1 related

Golovkina TV. 2000. A novel mechanism of resistance to mouse mammary tumor virus infection. J Virol 74(6):2752-9. [PubMed: 10684291]  [MGI Ref ID J:60602]

Kane M; Case LK; Wang C; Yurkovetskiy L; Dikiy S; Golovkina TV. 2011. Innate Immune Sensing of Retroviral Infection via Toll-like Receptor 7 Occurs upon Viral Entry. Immunity 35(1):135-45. [PubMed: 21723157]  [MGI Ref ID J:174379]

Purdy A; Case L; Duvall M; Overstrom-Coleman M; Monnier N; Chervonsky A; Golovkina T. 2003. Unique Resistance of I/LnJ Mice to a Retrovirus Is Due to Sustained Interferon gamma-dependent Production of Virus-neutralizing Antibodies. J Exp Med 197(2):233-43. [PubMed: 12538662]  [MGI Ref ID J:81554]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           FGB29

Colony Maintenance

Mating System	Sibling x Sibling         (Female x Male)   01-MAR-06
Diet Information	LabDiet® 5K52/5K67

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• View the complete collection of spontaneous mutants in the Mouse Mutant Resource.
• Genomic DNA is available for this strain from the Mouse DNA Resource.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

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