Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names DW.C3-Mlph+ Pit1+/J    (Changed: 21-SEP-06 ) DW.C3-ln+ Pit1+    (Changed: 15-DEC-04 ) Type Congenic; Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Homozygote x Homozygote         (Female x Male)   01-MAR-06 Species laboratory mouse Background Strain DW/J Donor Strain C3H/HeJ H2 Haplotype b Generation N11F21

Appearance
agouti, unaffected
Related Genotype: A/A

Description
This DW/J congenic strain is wildtype for both the leaden (+^Mlph-ln) and dwarf ( +^Pit1-dw) mutations and thus serves as a control strain for DW/J-Pit1^dw/+ Mlph^ln/Mlph^ln, Stock No. 000643.

Development
This control strain for DW/J was made to provide compatible hosts for ovarian transplantation. In 1966 the DW/J strain was sent to The Jackson Laboratory Animal Resources Mutant Stocks department. At this time the stock was maintained by tested sibling matings. In order to use ovarian transplants a compatible host and color coded strain was started by crossing a DW/J mouse to a C3H/HeJ .The offspring of this cross, a non leaden and non dwarf mouse, was crossed back to strain DW/J each generation to N10. At generation N11 the pairs were tested by breeding to be non-carriers of leaden and dwarf making this control line Mlph⁺ and Pit1⁺. It was cryopreserved in 1992 my mating the homozygous wild type males and females at N11 F20.

Control Information

		This is the control strain for DW/J Mlphln Pou1f1dw/J (000643).
Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Mlph

000112	B6.Cg-Sgk3fz H54 Mlphln/+ H54 +/J
000668	C57L/J
000643	DW/J Mlphln Pou1f1dw/J
001640	STOCK Mlphln-l1Rk3/J
002902	STOCK Pax3Sp Mlphln/J
000275	V/LeJ

View Strains carrying other alleles of Mlph     (6 strains)

Strains carrying other alleles of Pou1f1

000772	B6.DW-Pou1f1dw/J
000510	C3H/HeJ-Pou1f1dw-J/J
000643	DW/J Mlphln Pou1f1dw/J

View Strains carrying other alleles of Pou1f1     (3 strains)

Phenotype

Phenotype Information

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Pou1f1⁺ related

Developmental Biology Research
Growth Defects
      control strain

Endocrine Deficiency Research
Hypothalamus/Pituitary Defects
      control strain

Immunology and Inflammation Research
Immunodeficiency Associated with Other Defects
      control strain

Mouse/Human Gene Homologs
pituitary hormone deficiency
      wildtype

Currently there is no phenotype information for this strain.

Genes & Alleles

Gene & Allele Information

Allele Symbol		Mlph+
Allele Name		wild type
Allele Type		Not Applicable
Gene Symbol and Name		Mlph, melanophilin
Chromosome		1
Gene Common Name(s)		2210418F23Rik; 5031433I09Rik; AW228792; D1Wsu84e; DNA segment, Chr 1, Wayne State University 84, expressed; MGC2771; MGC59733; SLAC2-A; Slac-2a; expressed sequence AW228792; l(1)-3Rk; l1Rk3; leaden; lethal, Chr 1, Roderick 3; ln;
Allele Symbol		Pou1f1+
Allele Name		wild type
Allele Type		Not Applicable
Gene Symbol and Name		Pou1f1, POU domain, class 1, transcription factor 1
Chromosome		16
Gene Common Name(s)		CPHD1; GHF-1; GHF1; GHF1A; Hmp1; PIT1; PIT1Z; Pit-1; Pit1; Pit1-rs1; Snell dwarf; dw; dwarf; pituitary specific transcription factor 1; pituitary specific transcription factor 1, related sequence 1;

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Genotyping resources and troubleshooting

References

References

Additional References

Camper SA; Saunders TL; Katz RW; Reeves RH. 1990. The Pit-1 transcription factor gene is a candidate for the murine Snell dwarf mutation. Genomics 8(3):586-90. [PubMed: 1981057]  [MGI Ref ID J:10998]

Li S; Crenshaw EB 3d; Rawson EJ; Simmons DM; Swanson LW; Rosenfeld MG. 1990. Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1. Nature 347(6293):528-33. [PubMed: 1977085]  [MGI Ref ID J:10774]

Pou1f1⁺ related

Beamer WG; Sweet HO; Bronson RT; Shire JG; Orth DN; Davisson MT. 1994. Adrenocortical dysplasia: a mouse model system for adrenocortical insufficiency. J Endocrinol 141(1):33-43. [PubMed: 8014601]  [MGI Ref ID J:18027]

Health & husbandry

Health & Colony Maintenance Information

Colony Maintenance

Mating System	Homozygote x Homozygote         (Female x Male)   01-MAR-06

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Supply Details

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.

Supply Notes

Cryorecovery - Standard. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location). This strain is included in the Mouse Mutant Resource collection. Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

		This is the control strain for DW/J Mlphln Pou1f1dw/J (000643).
Considerations for Choosing Controls
USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
International - Control Pricing Information for Genetically Engineered Mutant Strains.

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Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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