Strain Name: |
DW.C3-Mlph+ Pou1f1+/J |
|---|---|
Stock Number: |
000681 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Former Name |
DW.C3-Mlph+ Pit1+/J (Changed: 21-SEP-06
) |
|
DW.C3-ln+ Pit1+ (Changed: 15-DEC-04
) | |
| Genes & Alleles | Mlph; Mlph+; Pou1f1; Pou1f1+; |
Product Information
Strain Details
Type JAX® GEMM® Strain - Congenic Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Mutant Strain Mating System Homozygote x Homozygote (Female x Male) Species laboratory mouse Background Strain DW/J Donor Strain C3H/HeJ H2 Haplotype b Generation N11F21 Appearance
agouti, unaffected
Related Genotype: A/AStrain Description
This DW/J congenic strain is wildtype for both the leaden (+Mlph-ln) and dwarf ( +Pit1-dw) mutations and thus serves as a control strain for DW/J-Pit1dw/+ Mlphln/Mlphln, Stock No. 000643.Strain Development
This control strain for DW/J was made to provide compatible hosts for ovarian transplantation. In 1966 the DW/J strain was sent to The Jackson Laboratory Animal Resources Mutant Stocks department. At this time the stock was maintained by tested sibling matings. In order to use ovarian transplants a compatible host and color coded strain was started by crossing a DW/J mouse to a C3H/HeJ .The offspring of this cross, a non leaden and non dwarf mouse, was crossed back to strain DW/J each generation to N10. At generation N11 the pairs were tested by breeding to be non-carriers of leaden and dwarf making this control line Mlph+ and Pit1+. It was cryopreserved in 1992 my mating the homozygous wild type males and females at N11 F20.
Gene & Allele Details
| Allele Symbol | Mlph+ | ||
|---|---|---|---|
| Allele Name | wild type | ||
| Gene Symbol and Name | Mlph, melanophilin | ||
| Chromosome | 1 | ||
| Gene Common Name(s) | 2210418F23Rik; 5031433I09Rik; AW228792; D1Wsu84e; DNA segment, Chr 1, Wayne State University 84, expressed; MGC2771; MGC59733; SLAC2-A; Slac-2a; expressed sequence AW228792; l(1)-3Rk; l1Rk3; leaden; lethal, Chr 1, Roderick 3; ln; | ||
| Allele Symbol | Pou1f1+ | ||
| Allele Name | wild type | ||
| Gene Symbol and Name | Pou1f1, POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1) | ||
| Chromosome | 16 | ||
| Gene Common Name(s) | GHF-1; GHF1; GHF1A; Hmp1; PIT1; PIT1Z; Pit-1; Pit1; Pit1-rs1; Snell dwarf; dw; dwarf; pituitary specific transcription factor 1; pituitary specific transcription factor 1, related sequence 1; | ||
Control Information
| This is the control strain for DW/J Mlphln Pou1f1dw/J (000643). | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of Mlph
000112 B6.Cg-Sgk3fz H54 Mlphln/+ H54 +/J 000668 C57L/J 000643 DW/J Mlphln Pou1f1dw/J 001640 STOCK Mlphln-l1Rk3/J 002902 STOCK Pax3Sp Mlphln/J 000275 V/LeJ View Strains carrying other alleles of Mlph (6 strains)
000772 B6.DW-Pou1f1dw/J 000510 C3H/HeJ-Pou1f1dw-J/J 000643 DW/J Mlphln Pou1f1dw/J
Additional Web Information
Congenic Nomenclature
Research Applications
This mouse can be used to support research in many areas including:Pou1f1+ related
Developmental Biology Research
Growth Defects (control strain)
Endocrine Deficiency Research
Hypothalamus/Pituitary Defects (control strain)
Immunology and Inflammation Research
Immunodeficiency Associated with Other Defects (control strain)
Mouse/Human Gene Homologs
pituitary hormone deficiency (wildtype)
References
Additional ReferencesPrice and Supply Information
| Strain Name: | DW.C3-Mlph+ Pou1f1+/J |
| Stock Number: | 000681 |
Price Details
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below |
| Control Information | View Control Information in Strain Details. |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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