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Strain Common Names

R3;

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Product Information

Strain Details

Type Inbred Strain Additional information on Inbred Strains. Mating System Sibling x Sibling         (Female x Male) Species laboratory mouse H2 Haplotype r Generation F135 (22-NOV-06)

Appearance
albino
Related Genotype: Tyr^c/Tyr^c

Strain Description
RIIIS/J mice have prolonged bleeding times with normal platelet activity and low levels of factor VIII:C and plasma von Willebrand factor antigen, making it a good animal model for human von Willebrand disease. This bleeding tendency is an incomplete dominant, autosomal trait. RIIIS/J mice also produce a low antibody response to several bacterial polysaccharide antigens and are reported to be resistant to collagen induced arthritis. Despite a B cell immunodeficiency, RIIS/J mice develop severe experimental autoimmune myasthenia gravis (EAMG) (Tuzun et al., 2004).

RIII/J have a high incidence of mammary tumors and ovarian tumors. RIIIS/J mice carry Mtv8, and Mtv14, but high incidence of tumors has not been reported in these mice. In fact, some studies indicate a resistance to chemically induced tumors. RIIIS/J mice have been reported to develop far fewer lung tumors than A/J or SWR/J mice subsequent to Urethan treatment. BALB/c x RIII F1 males are also highly resistant to diethylstilbesterol-cholesterol induced testicular tumors even though BALB/c is highly susceptible. RIIIS/J mice carry a spontaneous mutation, ldis1, that leads to a partial or complete disruption of the lens and cataract (Jablonski M, et al, 2004).

Strain Development
The RIIIS/J strain was developed as follows: an RIII/AnJ female was bred with a SEC/1ReJ male and an F1 female from this cross was bred to an RIII/AnJ male. Then an F1 female from this second mating was bred to an RIII/J male and inbreeding followed.

Colony Maintenance

Diet Information	LabDiet® 5K52/5K67

Phenotypic Data

Mouse Phenome Database
Festing Inbred Strain Characteristics: RIIIS

Additional Web Information

Genetic Quality Control Annual Report
JAX^® NOTES, April 1988; 433. H-2 Haplotypes of Mice from Jackson Laboratory Production Colonies.

Animal Health Reports

Room Number           AX11

Research Applications

This mouse can be used to support research in many areas including:

Hematological Research
Clotting Defects

Immunology and Inflammation Research
Autoimmunity (experimental autoimmune myasthenia gravis (EAMG))
Immunodeficiency (B cell deficiency)

Research Tools
Cancer Research (no detectable endogenous ecotropic MuLV DNA Sequences)

Sensorineural Research
Eye Defects

References

Additional References

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Price and Supply Information

Strain Name:	RIIIS/J
Stock Number:	000683

Price Details

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Supply Details

Standard Supply	Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.
Supply Notes	Usually shipped between four and six weeks of age. This strain is included in the Mouse Mutant Resource collection. Genomic DNA is available for this strain from the Mouse DNA Resource.
Licensing	See General Terms and Conditions below

General Terms and Conditions

View JAX^® Mice & Services Conditions of Use.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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