Description

Strain Information

Type Inbred Strain; Additional information on Inbred Strains. Visit our online Nomenclature tutorial. Mating System Sibling x Sibling         (Female x Male)   01-MAR-06 Species laboratory mouse H2 Haplotype r Generation F134+16 (05-DEC-12) Generation Definitions

Appearance
albino
Related Genotype: Tyr^c/Tyr^c

Description
RIIIS/J mice have prolonged bleeding times with normal platelet activity and low levels of factor VIII:C and plasma von Willebrand factor antigen, making it a good animal model for human von Willebrand disease. This bleeding tendency is an incomplete dominant, autosomal trait. RIIIS/J mice also produce a low antibody response to several bacterial polysaccharide antigens and are reported to be resistant to collagen induced arthritis. Despite a B cell immunodeficiency, RIIS/J mice develop severe experimental autoimmune myasthenia gravis (EAMG) (Tuzun et al., 2004).

RIII/J have a high incidence of mammary tumors and ovarian tumors. RIIIS/J mice carry Mtv8, and Mtv14, but high incidence of tumors has not been reported in these mice. In fact, some studies indicate a resistance to chemically induced tumors. RIIIS/J mice have been reported to develop far fewer lung tumors than A/J or SWR/J mice subsequent to Urethan treatment. BALB/c x RIII F1 males are also highly resistant to diethylstilbesterol-cholesterol induced testicular tumors even though BALB/c is highly susceptible. RIIIS/J mice carry a spontaneous mutation, ldis1, that leads to a partial or complete disruption of the lens and cataract (Jablonski M, et al, 2004).

Development
The RIIIS/J strain was developed as follows: an RIII/AnJ female was bred with a SEC/1ReJ male and an F1 female from this cross was bred to an RIII/AnJ male. Then an F1 female from this second mating was bred to an RIII/J male and inbreeding followed.

Additional Web Information

JAX^® NOTES, April 1988; 433. H-2 Haplotypes of Mice from Jackson Laboratory Production Colonies.

Phenotype

Phenotype Information

View Phenotypic Data

Phenotypic Data

Mouse Phenome Database
Festing Inbred Strain Characteristics: RIII

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Hematological Research
Clotting Defects

Immunology, Inflammation and Autoimmunity Research
Autoimmunity
      experimental autoimmune myasthenia gravis (EAMG)
Immunodeficiency
      B cell deficiency

Research Tools
Cancer Research
      no detectable endogenous ecotropic MuLV DNA Sequences

Sensorineural Research
Eye Defects

Genes & Alleles

Gene & Allele Information provided by MGI

Currently there are no related genes or alleles for this strain.

Genotyping

Genotyping Information

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11. [PubMed: 15081119]  [MGI Ref ID J:89298]

Additional References

Haqqi TM; Banerjee S; Anderson GD; David CS. 1989. RIII S/J (H-2r). An inbred mouse strain with a massive deletion of T cell receptor V beta genes. J Exp Med 169(6):1903-9. [PubMed: 2525171]  [MGI Ref ID J:21260]

Hiernaux JR; Baker PJ; McEvoy SJ; Stashak PW; Fauntleroy MB; Goidl EA. 1990. Characterization of the immunodeficiency of RIIIS/J mice: immune response to polysaccharide antigens. Infect Immun 58(5):1261-8. [PubMed: 1691141]  [MGI Ref ID J:25450]

Sweeney JD; Novak EK; Reddington M; Takeuchi KH; Swank RT. 1990. The RIIIS/J inbred mouse strain as a model for von Willebrand disease. Blood 76(11):2258-65. [PubMed: 2124152]  [MGI Ref ID J:25448]

Uz-Zaman T; Ignatowicz L; Sarkar NH. 2003. Mouse mammary tumor viruses expressed by RIII/Sa mice with a high incidence of mammary tumors interact with the V beta-2- and V beta-8-specific T cells during viral infection. Virology 314(1):294-304. [PubMed: 14517082]  [MGI Ref ID J:85844]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           FGB29

Colony Maintenance

Mating System	Sibling x Sibling         (Female x Male)   01-MAR-06
Diet Information	LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

General Supply Notes

• View the complete collection of spontaneous mutants in the Mouse Mutant Resource.
• Genomic DNA is available for this strain from the Mouse DNA Resource.

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Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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