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Strain Name:

NZB/BlNJ

Stock Number:

000684

Availability:

Level 4

Price and Supply Information

General Terms and Conditions

Strain Common Names      New Zealand Black;
Genes & Alleles   Hc;   Hc0;   Pctp;   PctpR120H;

Product Information

Strain Details

Type Inbred Strain
Additional information on Inbred Strains.
Mating SystemSibling x Sibling         (Female x Male)
Specieslaboratory mouse
H2 Haplotyped2 (see, Fischer Lindahl K 1997)
GenerationF206 (03-JAN-08)

Appearance
black
Related Genotype: a/a

Strain Description
NZB/BlNJ mice display a number of autoimmune abnormalities including hemolytic anemia, elevated levels of immunoglobulin, anti-DNA antibodies, anti-thymocyte antibodies, and circulating immune complexes causing glomerulonephritis. F1 hybrids of NZB/BlNJ and NZW/LacJ (NZBWF1/J, Stock No. 100008) are widely used as a model for autoimmune disease resembling human systemic lupus erythematosus. NZB/BlNJ mice, fed an atherogenic diet (1.25% cholesterol, 0.5% cholic acid and 15% fat), fail to develop atherosclerotic aortic lesions in contrast to several highly susceptible strains of mice (e.g. C57BL/6J, Stock No. 000664; C57L/J, Stock No. 000668, C57BR/cdJ, Stock No. 000667, and SM/J, Stock No. 000687).

Strain Development
Inbreeding of New Zealand Black (NZB) mice began at the University of Otago Medical School in 1948 by Bielschowsky (Bl). NZB/BlN mice from the National Institutes of Health were supplied to Dr. ES Russell at The Jackson Laboratory transferred to the production colony in 1969. The current generation of inbreeding is F166.

Gene & Allele Details

Allele Symbol Hc0
Allele Name deficient
Common Name(s) C5-; C5-d; C5-def; C5-deficient; hco;
Gene Symbol and Name Hc, hemolytic complement
Chromosome 2
Gene Common Name(s) C5; C5a; CPAMD4; FLJ17816; FLJ17822; He; MGC142298; RGD1561905;
General Note

This is an allele characteristic of various inbred mouse strains including the following: A/HeJ, AKR/J, DBA/2J, NZB/B1NJ, SWR/J, B10.D2/oSnJ

Hc was identified as a candidate gene for Abhr2 in a microarray analysis of lung mRNA from A/J, C3H/HeJ, and (A/J x C3H/HeJ)F1 x A/J backcross animals. Hc genotype shows statistically significant correlation to allergen-induced bronchial hyperresponsive phenotype. The A/J allele contains a 2 bp deletion resulting in deficient Hc mRNA and protein production and is associated with susceptibility to allergen-induced bronchial hyperresponsiveness. (J:108211)

Molecular Note A 2 base "TA" deletion at positions 62 and 63 of an 83 base pair exon near the 5' end of the gene is found in the following mouse strains: A/HeJ, AKR/J, DBA/2J, NZB/B1NJ, SWR/J, B10.D2/oSnJ. The consequence of this deletion is the creation of a stop codon starting four bases after the deletion. A truncated product of 216 amino acids is predicted as a result although contradictory reports exist that a larger pro-C5 protein may be synthesized. Nevertheless, macrophages from mouse strains carrying this allele do not secrete complement 5. [MGI Ref ID J:23983]
 
Allele Symbol PctpR120H
Allele Name R120H
Strain of OriginNZO
Gene Symbol and Name Pctp, phosphatidylcholine transfer protein
Chromosome 11
Gene Common Name(s) PC-TP; STARD2;
Molecular Note A G to A transition in exon 4 resulted in the arginine to histidine substitution at amino acid 120 in NZO, NZB/BINJ and NZW/LacJ strains. This mutation rendered the protein was inactive. [MGI Ref ID J:114974]

Colony Maintenance

Diet Information LabDiet® 5K52/5K67

Related Strains

Strains carrying   Hc0 allele
000645   A/HeJ
000646   A/J
000647   A/WySnJ
000648   AKR/J
000460   B10.D2-Hc0 H2d H2-T18c/o2SnJ
000461   B10.D2-Hc0 H2d H2-T18c/oSnJ
000657   CE/J
000671   DBA/2J
007048   DBA/2J-Gpnmb+/SjJ
001800   FVB/NJ
001491   FVB/NMob
000674   I/LnJ
001303   NOD.CB17-Prkdcscid/J
001976   NOD/ShiLtJ
000682   RF/J
000688   ST/bJ
000689   SWR/J
View Strains carrying   Hc0     (17 strains)

Strains carrying   PctpR120H allele
002105   NZO/HlLtJ
001058   NZW/LacJ
View Strains carrying   PctpR120H     (2 strains)

View Strains carrying other alleles of Hc     (5 strains)

Strains carrying other alleles of Pctp
006607   B6.129-Pctptm1Bor/J
View Strains carrying other alleles of Pctp     (1 strain)

Phenotypic Data

Mouse Phenome Database
Mouse Phenome Database / SNP Facility
Festing Inbred Strain Characteristics: NZB

Additional Web Information

Genetic Quality Control Annual Report
JAX® NOTES, April 1988; 433. H-2 Haplotypes of Mice from Jackson Laboratory Production Colonies.
JAX® NOTES, January 1988; 432. Arthritis Models in the Mouse.
JAX® NOTES, Summer 1992; 450. Mutation at the Glucosephosphate Isomerase Locus in NZB/BlNJ.

Animal Health Reports

Room Number           MP16

Research Applications

This mouse can be used to support research in many areas including:

Cardiovascular Research
Diet-Induced Atherosclerosis (Relatively Resistant)

Developmental Biology Research
Lymphoid Tissue Defects (hematopoietic defects)

Hematological Research
Anemia, Iron Deficiency and Transport Defects
Immunological Defects

Immunology and Inflammation Research
Autoimmunity (hemolytic anemia)

Research Tools
Immunology and Inflammation Research (specific complement deficiency) (C5 complement)

Hc0 related

Immunology and Inflammation Research
Immunodeficiency (specific complement deficiency)

Research Tools
Immunology and Inflammation Research (specific complement deficiency) (C5 complement)

References

Selected Reference(s)

Fischer Lindahl K. 1997. On naming H2 haplotypes: functional significance of MHC class Ib alleles. Immunogenetics 46(1):53-62. [PubMed: 9148789]  [MGI Ref ID J:41130]

Haskell BD; Flurkey K; Duffy TM; Sargent EE; Leiter EH. 2002. The diabetes-prone NZO/HlLt strain. I. Immunophenotypic comparison to the related NZB/BlNJ and NZW/LacJ strains. Lab Invest 82(7):833-42. [PubMed: 12118085]  [MGI Ref ID J:77828]

Korstanje R; Albers JJ; Wolfbauer G; Li R; Tu AY; Churchill GA; Paigen BJ. 2004. Quantitative trait locus mapping of genes that regulate phospholipid transfer activity in SM/J and NZB/BlNJ inbred mice. Arterioscler Thromb Vasc Biol 24(1):155-60. [PubMed: 14592843]  [MGI Ref ID J:86340]

Korstanje R; Li R; Howard T; Kelmenson P; Marshall J; Paigen B; Churchill G. 2004. Influence of sex and diet on quantitative trait loci for HDL cholesterol levels in an SM/J by NZB/BlNJ intercross population. J Lipid Res 45(5):881-8. [PubMed: 14993241]  [MGI Ref ID J:89309]

Nishina PM; Wang J; Toyofuku W; Kuypers FA; Ishida BY; Paigen B. 1993. Atherosclerosis and plasma and liver lipids in nine inbred strains of mice. Lipids 28(7):599-605. [PubMed: 8355588]  [MGI Ref ID J:13267]

Paigen B; Ishida BY; Verstuyft J; Winters RB; Albee D. 1990. Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice. Arteriosclerosis 10(2):316-23. [PubMed: 2317166]  [MGI Ref ID J:22615]

Paigen B; Morrow A; Brandon C; Mitchell D; Holmes P. 1985. Variation in susceptibility to atherosclerosis among inbred strains of mice. Atherosclerosis 57(1):65-73. [PubMed: 3841001]  [MGI Ref ID J:109950]

Pitman WA; Korstanje R; Churchill GA; Nicodeme E; Albers JJ; Cheung MC; Staton MA; Sampson SS; Harris S; Paigen B. 2002. Quantitative trait locus mapping of genes that regulate HDL cholesterol in SM/J and NZB/B1NJ inbred mice. Physiol Genomics 9(2):93-102. [PubMed: 12006675]  [MGI Ref ID J:76707]

Additional References

Price and Supply Information

Strain Name: NZB/BlNJ
Stock Number: 000684

Price Details

IMPORTANT NOTE: Prices are based on shipping destination. The shipping destinations are:

*Pricing for Shipping Destination selected:

        International

Price(s) in US dollars ($)Genotype(s) Provided
3-5 weeks $59.60 Female
6 weeks $62.10 Female
7 weeks $64.60 Female
8 weeks $67.10 Female
9 weeks $69.60 Female
10 weeks $72.10 Female
3-5 weeks $47.40 Male
6 weeks $49.90 Male
7 weeks $52.40 Male
8 weeks $54.90 Male
9 weeks $57.40 Male
10 weeks $59.90 Male

Supply Details

Standard SupplyLevel 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.
Supply Notes Histology and Tissue Collection Services are available for all JAX® Mice strains. For more information, please contact Customer Service at orderquest@jax.org or 1-207-288-5845.
Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
Genomic DNA is available for this strain from the Mouse DNA Resource.
LicensingSee General Terms and Conditions below  

General Terms and Conditions

View JAX® Mice & Services Conditions of Use.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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