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| SJL mice display a very high incidence of reticulum cell sarcomas resembling Hodgkin's disease by approximately one year of age. This strain is also characterized by extreme aggression in males and its susceptibility to experimental autoimmune encephalomyelitis (EAE) for multiple sclerosis research. SJL/J mice develop a spontaneous myopathy resulting from a splice-site mutation in the Dysferlin gene resulting in decreased levels of dysferlin protein in SJL/J mice and making this strain a good model for limb girdle muscular dystrophy 2B. SJL mice, fed an atherogenic diet (1.25% cholesterol, 0.5% cholic acid and 15% fat), fail to develop atherosclerotic aortic lesions in contrast to several highly susceptible strains of mice. SJL are immunocompetent but have elevated levels of circulating T cells. | ||||||||||||||
- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
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Description
Strain Information
Former Names SJL/J-Pde6brd1 (Changed: 19-MAR-08 ) Type Inbred Strain; Additional information on Inbred Strains. Visit our online Nomenclature tutorial. Mating System Sibling x Sibling (Female x Male) 01-MAR-06 Species laboratory mouse H2 Haplotype s2 (see, Fischer Lindahl K 1997 and Shen FW 1982) Generation F186 (03-JAN-08)
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albino
Related Genotype: Oca2p Tyrc/Oca2p TyrcImportant Note
This strain is homozygous for the retinal degeneration allele Pde6brd1. See article "Genetic Background Effects: Can Your Mice See?", JAX® NOTES Spring 2002, No. 485.Description
SJL mice display a very high incidence of reticulum cell sarcomas resembling Hodgkin's disease by approximately one year of age. Sarcomas first appear in the Peyer's patches and mesenteric lymph nodes and later in the spleen, liver, thymus and other lymph nodes. Most of the tumors are mixed-cell types classified as type B reticulum cell neoplasms, but a few are type A histiocytomas. This strain is also characterized by extreme aggression in males and its susceptibility to experimental autoimmune encephalomyelitis (EAE) for multiple sclerosis research. SJL/J mice develop a spontaneous myopathy resulting from a splice-site mutation in the Dysferlin gene. This Dysfim allele has been shown to result in decreased levels of dysferlin protein in SJL/J mice and makes this strain a good model for limb girdle muscular dystrophy 2B. This spontaneous myopathy is characterized by a progressive loss of muscle mass and strength corresponding with an increase in muscle pathology including muscle fibers with central nuclei, size variation, splitting, inflammatory infiltrate, necrosis, and eventual replacement of muscle fiber with fat. While muscle weakness can be detected as early as three weeks of age the greatest pathology occurs after six months of age. SJL/J mice have also been shown to have an increased rate of muscle regeneration after injury when compared to BALB/c mice.SJL mice, fed an atherogenic diet (1.25% cholesterol, 0.5% cholic acid and 15% fat), fail to develop atherosclerotic aortic lesions in contrast to several highly susceptible strains of mice (e.g. C57BL/6J, Stock No. 000664; C57L/J, Stock No. 000668, C57BR/cdJ, Stock No. 000667, and SM/J, Stock No. 000687). SJL/J are also useful as a control strain for studying immune defects in NOD/ShiLtJ mice (Stock No. 001976), a model for type 1 diabetes (IDDM). Both NOD and SJL/J are derived from Swiss mice; SJL are immunocompetent but have elevated levels of circulating T cells.
Development
SJL mice were developed by James Lambert at The Jackson Laboratory in 1955 from three different sources of Swiss Webster mice.
Related Strains
Strains carrying Il2m1 allele
000486 MRL/MpJ 001289 NOD/ShiLt 001976 NOD/ShiLtJ View Strains carrying Il2m1 (3 strains)
000646 A/J 000648 AKR/J 000779 AKXD14/TyJ 000780 AKXD23/TyJ 000764 AKXD27/TyJ 000777 AKXD6/TyJ 000667 C57BR/cdJ 000668 C57L/J 000669 C58/J 000682 RF/J 000644 SEA/GnJ 000688 ST/bJ
006830 129-Dysftm1Kcam/J 000646 A/J
006102 B10.Cg-H2k Tg(Il2/NFAT-luc)83Rinc/J 002252 B6.129P2-Il2tm1Hor/J 006098 B6.Cg-Tg(Il2/NFAT-luc)83Rinc/J 002229 C.129P2(B6)-Il2tm1Hor/J 002228 C3.129P2(B6)-Il2tm1Hor/J 002573 NOD.129P2(B6)-Il2tm1Hor/DvsJ 003852 NOD.B6-Il2C57BL/6/Lt
004297 B6.CXB1-Pde6brd10/J 005252 B6EiC3Sn.BLiA-Ts(1716)65Dn/DnJ 003647 B6EiC3Sn.BLiAF1 002802 C3.BLiA Pde6b+-Krd/J 001979 C3A.BLiA-Pde6b+.O20-Prph2Rd2/J 001912 C3A.BLiA-Pde6b+/J 003648 C3Sn.BLiA-Pde6b+/Dn 004766 C57BL/6J-Pde6brd1-2J/J 004828 FVB.129P2-Pde6b+ Tyrc-ch/AntJ 004808 STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
000690 129P3/J 000765 AKXD13/TyJ 000954 AKXD15/TyJ 001093 AKXD18/TyJ 000947 AKXD22/TyJ 000763 AKXD9/TyJ 000654 CBA/CaJ 000670 DBA/1J
Additional Web Information
Genetic Quality Control Annual Report
JAX® NOTES, April 1988; 433. H-2 Haplotypes of Mice from Jackson Laboratory Production Colonies.
JAX® NOTES, Spring 1990; 441. Imperforate Vagina and Mucometra in Mice.
JAX® NOTES, Spring 1999; 477. Control Strains for NOD/LtJ Mice in Diabetes Research.
JAX® NOTES, Spring 2002; 485. Genetic Background Effects: Can Your Mice See?
JAX® NOTES, Spring 2003; 489. Malocclusion in the Laboratory Mouse.
JAX® NOTES, Spring 2003; 489. Role of NK and NKT Cells in Immunity and Disease.
JAX® NOTES, Summer 1994; 458. Ly5 Gene Nomenclature, C57BL/6J and SJL/J - A History of Change.
JAX® NOTES, Summer 2003; 490. Hydrocephalus in Laboratory Mice.
Phenotype
Phenotype Information
Body Weight Information - JAX® Mice Strain SJL/J (000686)Mouse Phenome Database
(This chart reflects the typical correlation between body weight and age for mice maintained in production colonies at The Jackson Laboratory.)
Mouse Phenome Database - activity and motor function
Mouse Phenome Database - atherogenic diet
Mouse Phenome Database - body weight
Mouse Phenome Database - cardiovascular
Mouse Phenome Database - drinking preference
Mouse Phenome Database - food and water intake
Mouse Phenome Database - hematology
Mouse Phenome Database - hormones
Festing Inbred Strain Characteristics: SJL
This mouse can be used to support research in many areas including:
Dysfim relatedCancer Research
Increased Tumor Incidence
Other Tissues/Organs: reticulum cell sarcomas, Hodgkin's disease
Cardiovascular Research
Diet-Induced Atherosclerosis
Relatively Resistant
Diabetes and Obesity Research
Type 1 Diabetes (IDDM) Analysis Strains
Related Inbred Strains
Immunology and Inflammation Research
Autoimmunity
experimental allergic encephalomyelitis (EAE)
Neurobiology Research
Angelman syndrome
Research Tools
Immunology and Inflammation Research
NK Cell Deficiency
Sensorineural Research
Retinal Degeneration
Homozygous for Pde6brd1
Pde6brd1 relatedMouse/Human Gene Homologs
muscular dystrophy, limb-girdle
type 2B
retinitis pigmentosa, autosomal recessive
Sensorineural Research
Retinal Degeneration
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Dysfim | ||
|---|---|---|---|
| Allele Name | inflammatory myopathy | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | SJL-Dysf; | ||
| Strain of Origin | SJL | ||
| Gene Symbol and Name | Dysf, dysferlin | ||
| Chromosome | 6 | ||
| Gene Common Name(s) | 2310004N10Rik; AI604795; D6Pas3; DNA segment, Chr 6, Pasteur Institute 3; FER1L1; FLJ00175; FLJ90168; LGMD2B; RIKEN cDNA 2310004N10 gene; expressed sequence AI604795; | ||
| Molecular Note | A 171 bp in-frame deletion in the encoded mRNA is predicted to remove 57 amino acids from the corresponding protein. This region corresponds to most of the fourth C2 domain of the protein, and the deletion likely results in instability of the protein. The molecular basis for the mutation is due to a splicing mutation in the gene, resulting from a deletion of a small tandem repeat. [MGI Ref ID J:67994] | ||
| Allele Symbol | Il2m1 | ||
| Allele Name | mutation 1 | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | multiple strains | ||
| Gene Symbol and Name | Il2, interleukin 2 | ||
| Chromosome | 3 | ||
| Gene Common Name(s) | IL-2; Il-2; TCGF; lymphokine; | ||
| Molecular Note | This hypoactive polymorphism, found in MRL/MpJ, SJL/J, and NOD/ShiLtJ inbred strains, includes a smaller polyglutamine tract predicted to shorten the first alpha helix, which forms part of the IL2 receptor binding site. [MGI Ref ID J:75331] | ||
| Allele Symbol | Pde6brd1 | ||
| Allele Name | retinal degeneration 1 | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | Pdebrd1; rd; rd-1; rd1; rodless retina; | ||
| Gene Symbol and Name | Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide | ||
| Chromosome | 5 | ||
| Gene Common Name(s) | CSNB3; PDEB; Pdeb; RP40; nmf137; phosphodiesterase, cGMP, rod receptor, beta polypeptide; r; rd; rd-1; rd1; rd10; retinal degeneration; retinal degeneration 1; retinal degeneration 10; | ||
| General Note | CBA/J mice carry this allele. | ||
| Molecular Note | Two mutations have been identified in rd1 mice. A murine leukimia virus (Xmv-28) insertion in reverse orientation in intron 1 is found in all mouse strains with the rd1 phenotype. Further, a nonsense mutation (C to A transversion) in codon 347 that results in a truncation eliminating more than half of the predicted encoded protein, including the catalytic domain has also been identified in all rd1 strains of mice. A specific degradation of mutant transcript during or after pre-mRNA splicing is suggested. [MGI Ref ID J:11513] [MGI Ref ID J:4366] [MGI Ref ID J:51361] | ||
| Allele Symbol | Rmcfs | ||
| Allele Name | MCF sensitive | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | multiple strains | ||
| Gene Symbol and Name | Rmcf, resistance to MCF virus | ||
| Chromosome | 5 | ||
| General Note |
This locus controls resistance and susceptibility of cells in tissue culture to infection by mink cell focus-forming murine leukemia viruses. The allele Rmcfr determines resistance and occurs in strains DBA/1, DBA/2, and CBA/Ca; the allele Rmcfs determines susceptibility and occurs in strains AKR/J, C57BL/6, BALB/c, CBA/J, NFS, NZB, 129/J, and many others. Heterozygotes are as resistant as the resistant parent or nearly so. Rmcf is different from and independent of Fv1,a locus that controls susceptibility to infection by ecotropic viruses. Rmcf is located on Chr 5 close to Hm near the centromeric end (J:7108). Rmcfr protects (AKR x CBA/Ca)F1 and (AKR x DBA/2)F1 hybrids from development of spontaneous thymic lymphomas and reduces the incidence of MCF-induced thymic lymphomas (J:7175). It also reduces susceptibility of cells of Sxvs/Sxvr mice to exogenous xenotropic viruses (J:7951). In addition, in strains susceptible to Friend virus-induced erythroleukemia, a condition thought to be due to the replication of MCF virus, Rmcfr increases resistance to the virus-induced erythroleukemia. It may cause resistance by coding for or regulating the production of an MCF-related envelope glycoprotein that blocks the receptor for MCF viruses (J:8074). This conclusion is reinforced by the findings of Buller et al. (J:8497), who showed that the Rmcfr allele contains an endogenous MCF gp70 env gene and that theRmcfs allele, at least in some strains (C57BL/6, CBA/J, and A/WySn), contains a xenotropic gp70 env gene. Presumably the MCF gp70 inhibits exogenous MCF infection in vitro by a mechanism of viral interference. | ||
| Molecular Note | This locus controls resistance of cells to infection by mink cell focus-forming murine leukemia viruses. The recessive s (susceptible) allele is found in AKR/J, C57BL/6, BALB/c, CBA/J, NFS, NZB and 129/J. | ||
Genotyping
Genotyping Information
Inbred mouse strains are maintained through sibling (sister x brother) matings; no genotyping required.
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Bittner RE; Anderson LV; Burkhardt E; Bashir R; Vafiadaki E; Ivanova S; Raffelsberger T; Maerk I; Hoger H; Jung M; Karbasiyan M; Storch M; Lassmann H; Moss JA; Davison K; Harrison R; Bushby KM; Reis A. 1999. Dysferlin deletion in SJL mice (SJL-Dysf) defines a natural model for limb girdle muscular dystrophy 2B [letter] Nat Genet 23(2):141-2. [PubMed: 10508505] [MGI Ref ID J:57764]
Crispens CG. 1973. Some characteristics of strain SJL-JDg mice. Lab Anim Sci 23(3):408-13. [PubMed: 4351481] [MGI Ref ID J:25445]
Dal Canto MC; Melvold RW; Kim BS; Miller SD. 1995. Two models of multiple sclerosis: experimental allergic encephalomyelitis (EAE) and Theiler's murine encephalomyelitis virus (TMEV) infection. A pathological and immunological comparison. Microsc Res Tech 32(3):215-29. [PubMed: 8527856] [MGI Ref ID J:109910]
Fischer Lindahl K. 1997. On naming H2 haplotypes: functional significance of MHC class Ib alleles. Immunogenetics 46(1):53-62. [PubMed: 9148789] [MGI Ref ID J:41130]
Fujinaga S; Poel WE; Williams WC; Dmochowski L. 1970. Biological and morphological studies of SJL-J strain reticulum cell neoplasms induced and transmitted serially in low-leukemia-strain mice. Cancer Res 30(3):729-42. [PubMed: 4316600] [MGI Ref ID J:25329]
McGeachie JK; Grounds MD. 1995. Retarded myogenic cell replication in regenerating skeletal muscles of old mice: an autoradiographic study in young and old BALBc and SJL/J mice. Cell Tissue Res 280(2):277-82. [PubMed: 7781025] [MGI Ref ID J:25692]
Mitchell CA; McGeachie JK; Grounds MD. 1992. Cellular differences in the regeneration of murine skeletal muscle: a quantitative histological study in SJL/J and BALB/c mice. Cell Tissue Res 269(1):159-66. [PubMed: 1423478] [MGI Ref ID J:2981]
Nishina PM; Wang J; Toyofuku W; Kuypers FA; Ishida BY; Paigen B. 1993. Atherosclerosis and plasma and liver lipids in nine inbred strains of mice. Lipids 28(7):599-605. [PubMed: 8355588] [MGI Ref ID J:13267]
Paigen B; Ishida BY; Verstuyft J; Winters RB; Albee D. 1990. Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice. Arteriosclerosis 10(2):316-23. [PubMed: 2317166] [MGI Ref ID J:22615]
Paigen B; Morrow A; Brandon C; Mitchell D; Holmes P. 1985. Variation in susceptibility to atherosclerosis among inbred strains of mice. Atherosclerosis 57(1):65-73. [PubMed: 3841001] [MGI Ref ID J:109950]
Shen FW; Chorney MJ; Boyse EA. 1982. Further polymorphism of the Tla locus defined by monoclonal TL antibodies. Immunogenetics 15(6):573-8. [PubMed: 7106865] [MGI Ref ID J:6828]
Vafiadaki E; Reis A; Keers S; Harrison R; Anderson LV; Raffelsberger T; Ivanova S; Hoger H; Bittner RE; Bushby K; Bashir R. 2001. Cloning of the mouse dysferlin gene and genomic characterization of the SJL-Dysf mutation. Neuroreport 12(3):625-9. [PubMed: 11234777] [MGI Ref ID J:67994]
Weller AH; Magliato SA; Bell KP; Rosenberg NL. 1997. Spontaneous myopathy in the SJL/J mouse: pathology and strength loss. Muscle Nerve 20(1):72-82. [PubMed: 8995586] [MGI Ref ID J:38007]
Additional References
Moy SS; Nadler JJ; Young NB; Nonneman RJ; Segall SK; Andrade GM; Crawley JN; Magnuson TR. 2008. Social approach and repetitive behavior in eleven inbred mouse strains. Behav Brain Res 191(1):118-29. [PubMed: 18440079] [MGI Ref ID J:138681]
Rohan RM; Fernandez A; Udagawa T; Yuan J; D'Amato RJ. 2000. Genetic heterogeneity of angiogenesis in mice. FASEB J 14(7):871-6. [PubMed: 10783140] [MGI Ref ID J:61808]
Smith BK; Andrews PK; West DB. 2000. Macronutrient diet selection in thirteen mouse strains. Am J Physiol Regul Integr Comp Physiol 278(4):R797-805. [PubMed: 10749765] [MGI Ref ID J:61602]
Tsunoda I; Kuang LQ; Theil DJ; Fujinami RS. 2000. Antibody association with a novel model for primary progressive multiple sclerosis: induction of relapsing-remitting and progressive forms of EAE in H2s mouse strains. Brain Pathol 10(3):402-18. [PubMed: 10885659] [MGI Ref ID J:137818]
Tsunoda I; Libbey JE; Kuang LQ; Terry EJ; Fujinami RS. 2005. Massive apoptosis in lymphoid organs in animal models for primary and secondary progressive multiple sclerosis. Am J Pathol 167(6):1631-46. [PubMed: 16314476] [MGI Ref ID J:137817]
West DB; Boozer CN; Moody DL; Atkinson RL. 1992. Dietary obesity in nine inbred mouse strains. Am J Physiol 262(6 Pt 2):R1025-32. [PubMed: 1621856] [MGI Ref ID J:1348]
Xie C; Sharma R; Wang H; Zhou XJ; Mohan C. 2004. Strain distribution pattern of susceptibility to immune-mediated nephritis. J Immunol 172(8):5047-55. [PubMed: 15067087] [MGI Ref ID J:122988]
Dysfim relatedIl2m1 relatedChiu YH; Hornsey MA; Klinge L; Jorgensen LH; Laval SH; Charlton R; Barresi R; Straub V; Lochmuller H; Bushby K. 2009. Attenuated muscle regeneration is a key factor in dysferlin-deficient muscular dystrophy. Hum Mol Genet 18(11):1976-89. [PubMed: 19286669] [MGI Ref ID J:148110]
Heiman-Patterson TD; Deitch JS; Blankenhorn EP; Erwin KL; Perreault MJ; Alexander BK; Byers N; Toman I; Alexander GM. 2005. Background and gender effects on survival in the TgN(SOD1-G93A)1Gur mouse model of ALS. J Neurol Sci 236(1-2):1-7. [PubMed: 16024047] [MGI Ref ID J:128550]
Kostek CA; Dominov JA; Miller JB. 2002. Up-regulation of MHC class I expression accompanies but is not required for spontaneous myopathy in dysferlin-deficient SJL/J mice. Am J Pathol 160(3):833-9. [PubMed: 11891182] [MGI Ref ID J:75304]
Nagaraju K; Rawat R; Veszelovszky E; Thapliyal R; Kesari A; Sparks S; Raben N; Plotz P; Hoffman EP. 2008. Dysferlin Deficiency Enhances Monocyte Phagocytosis: A Model for the Inflammatory Onset of Limb-Girdle Muscular Dystrophy 2B. Am J Pathol 172(3):774-785. [PubMed: 18276788] [MGI Ref ID J:132272]
Suzuki N; Aoki M; Hinuma Y; Takahashi T; Onodera Y; Ishigaki A; Kato M; Warita H; Tateyama M; Itoyama Y. 2005. Expression profiling with progression of dystrophic change in dysferlin-deficient mice (SJL). Neurosci Res 52(1):47-60. [PubMed: 15811552] [MGI Ref ID J:101826]
Turk R; Sterrenburg E; van der Wees CG; de Meijer EJ; de Menezes RX; Groh S; Campbell KP; Noguchi S; van Ommen GJ; den Dunnen JT; 't Hoen PA. 2006. Common pathological mechanisms in mouse models for muscular dystrophies. FASEB J 20(1):127-9. [PubMed: 16306063] [MGI Ref ID J:104560]
von der Hagen M; Laval SH; Cree LM; Haldane F; Pocock M; Wappler I; Peters H; Reitsamer HA; Hoger H; Wiedner M; Oberndorfer F; Anderson LV; Straub V; Bittner RE; Bushby KM. 2005. The differential gene expression profiles of proximal and distal muscle groups are altered in pre-pathological dysferlin-deficient mice. Neuromuscul Disord 15(12):863-77. [PubMed: 16288871] [MGI Ref ID J:106591]
Pde6brd1 relatedChoi Y; Simon-Stoos K; Puck J. 2002. Hypo-active variant of IL-2 and associated decreased T cell activation contribute to impaired apoptosis in autoimmune prone MRL mice. Eur J Immunol 32(3):677-85. [PubMed: 11857342] [MGI Ref ID J:75331]
Rmcfs relatedAcosta ML; Fletcher EL; Azizoglu S; Foster LE; Farber DB; Kalloniatis M. 2005. Early markers of retinal degeneration in rd/rd mice. Mol Vis 11:717-28. [PubMed: 16163270] [MGI Ref ID J:103970]
Aftab U; Jiang C; Tucker B; Kim JY; Klassen H; Miljan E; Sinden J; Young M. 2009. Growth kinetics and transplantation of human retinal progenitor cells. Exp Eye Res 89(3):301-10. [PubMed: 19524569] [MGI Ref ID J:151412]
Ahuja S; Ahuja-Jensen P; Johnson LE; Caffe AR; Abrahamson M; Ekstrom PA; van Veen T. 2008. rd1 Mouse retina shows an imbalance in the activity of cysteine protease cathepsins and their endogenous inhibitor cystatin C. Invest Ophthalmol Vis Sci 49(3):1089-96. [PubMed: 18326735] [MGI Ref ID J:133024]
Ahuja-Jensen P; Johnsen-Soriano S; Ahuja S; Bosch-Morell F; Sancho-Tello M; Romero FJ; Abrahamson M; van Veen T. 2007. Low glutathione peroxidase in rd1 mouse retina increases oxidative stress and proteases. Neuroreport 18(8):797-801. [PubMed: 17471069] [MGI Ref ID J:122802]
Alvarez-Lopez C; Cernuda-Cernuda R; Alcorta E; Alvarez-Viejo M; Manuel Garcia-Fernandez J. 2004. Altered endogenous activation of CREB in the suprachiasmatic nucleus of mice with retinal degeneration. Brain Res 1024(1-2):137-45. [PubMed: 15451375] [MGI Ref ID J:92980]
Alvarez-Lopez C; Cernuda-Cernuda R; Garcia-Fernandez JM. 2006. The mPer1 clock gene expression in the rd mouse suprachiasmatic nucleus is affected by the retinal degeneration. Brain Res 1087(1):134-41. [PubMed: 16626665] [MGI Ref ID J:109668]
Alvarez-Lopez C; Cernuda-Cernuda R; Paniagua MA; Alvarez-Viejo M; Fernandez-Lopez A; Garcia-Fernandez JM. 2004. The transcription factor CREB is phosphorylated in neurons of the piriform cortex of blind mice in response to illumination of the retina. Neurosci Lett 357(3):223-6. [PubMed: 15003290] [MGI Ref ID J:121036]
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Azadi S; Paquet-Durand F; Medstrand P; van Veen T; Ekstrom PA. 2006. Up-regulation and increased phosphorylation of protein kinase C (PKC) delta, mu and theta in the degenerating rd1 mouse retina. Mol Cell Neurosci 31(4):759-73. [PubMed: 16503160] [MGI Ref ID J:108601]
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Ball SL; Powers PA; Shin HS; Morgans CW; Peachey NS; Gregg RG. 2002. Role of the beta(2) subunit of voltage-dependent calcium channels in the retinal outer plexiform layer. Invest Ophthalmol Vis Sci 43(5):1595-603. [PubMed: 11980879] [MGI Ref ID J:80080]
Bi A; Cui J; Ma YP; Olshevskaya E; Pu M; Dizhoor AM; Pan ZH. 2006. Ectopic expression of a microbial-type rhodopsin restores visual responses in mice with photoreceptor degeneration. Neuron 50(1):23-33. [PubMed: 16600853] [MGI Ref ID J:122947]
Bibb LC; Holt JK; Tarttelin EE; Hodges MD; Gregory-Evans K; Rutherford A; Lucas RJ; Sowden JC; Gregory-Evans CY. 2001. Temporal and spatial expression patterns of the CRX transcription factor and its downstream targets. Critical differences during human and mouse eye development. Hum Mol Genet 10(15):1571-9. [PubMed: 11468275] [MGI Ref ID J:70841]
Blanks JC; Bok D. 1977. An autoradiographic analysis of postnatal cell proliferation in the normal and degenerative mouse retina. J Comp Neurol 174(2):317-27. [PubMed: 864040] [MGI Ref ID J:5812]
Bowes C; Danciger M; Kozak CA; Farber DB. 1989. Isolation of a candidate cDNA for the gene causing retinal degeneration in the rd mouse [published erratum appears in Proc Natl Acad Sci U S A 1990 Feb;87(4):1625] Proc Natl Acad Sci U S A 86(24):9722-6. [PubMed: 2481314] [MGI Ref ID J:10184]
Bowes C; Li T; Danciger M; Baxter LC; Applebury ML; Farber DB. 1990. Retinal degeneration in the rd mouse is caused by a defect in the beta subunit of rod cGMP-phosphodiesterase [see comments] Nature 347(6294):677-80. [PubMed: 1977087] [MGI Ref ID J:10777]
Bowes C; Li T; Frankel WN; Danciger M; Coffin JM; Applebury ML; Farber DB. 1993. Localization of a retroviral element within the rd gene coding for the beta subunit of cGMP phosphodiesterase. Proc Natl Acad Sci U S A 90(7):2955-9. [PubMed: 8385352] [MGI Ref ID J:4366]
Bumsted KM; Rizzolo LJ; Barnstable CJ. 2001. Defects in the MITF(mi/mi) apical surface are associated with a failure of outer segment elongation. Exp Eye Res 73(3):383-92. [PubMed: 11520113] [MGI Ref ID J:115620]
Caley DW; Johnson C; Liebelt RA. 1972. The postnatal development of the retina in the normal and rodless CBA mouse: a light and electron microscopic study. Am J Anat 133(2):179-212. [PubMed: 5009246] [MGI Ref ID J:5250]
Cameron MA; Pozdeyev N; Vugler AA; Cooper H; Iuvone PM; Lucas RJ. 2009. Light regulation of retinal dopamine that is independent of melanopsin phototransduction. Eur J Neurosci 29(4):761-7. [PubMed: 19200071] [MGI Ref ID J:146469]
Carter-Dawson LD; LaVail MM; Sidman RL. 1978. Differential effect of the rd mutation on rods and cones in the mouse retina. Invest Ophthalmol Vis Sci 17(6):489-98. [PubMed: 659071] [MGI Ref ID J:5988]
Cayouette M; Gravel C. 1997. Adenovirus-mediated gene transfer of ciliary neurotrophic factor can prevent photoreceptor degeneration in the retinal degeneration (rd) mouse. Hum Gene Ther 8(4):423-30. [PubMed: 9054517] [MGI Ref ID J:39262]
Cayouette M; Smith SB; Becerra SP; Gravel C. 1999. Pigment epithelium-derived factor delays the death of photoreceptors in mouse models of inherited retinal degenerations. Neurobiol Dis 6(6):523-32. [PubMed: 10600408] [MGI Ref ID J:59343]
Chang B; Hawes NL; Hurd RE; Davisson MT; Nusinowitz S; Heckenlively JR. 2002. Retinal degeneration mutants in the mouse. Vision Res 42(4):517-25. [PubMed: 11853768] [MGI Ref ID J:75095]
Chen B; Cepko CL. 2009. HDAC4 regulates neuronal survival in normal and diseased retinas. Science 323(5911):256-9. [PubMed: 19131628] [MGI Ref ID J:143166]
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Health & husbandry
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Room Number AX3
Room Number MP16
Room Number RB04
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Mating System Sibling x Sibling (Female x Male) 01-MAR-06 Diet Information LabDiet® 5K52/5K67
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Weeks of Age Price (US dollars $) Gender 3 weeks $20.75 Female $19.70 Male 4 weeks $20.75 Female $19.70 Male 5 weeks $21.00 Female $19.70 Male 6 weeks $22.85 Female 7 weeks $24.95 Female 8 weeks $27.05 Female 9 weeks $29.05 Female 10 weeks $31.10 Female
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Weeks of Age Price (US dollars $) Gender 3 weeks $27.00 Female $25.70 Male 4 weeks $27.00 Female $25.70 Male 5 weeks $27.30 Female $25.70 Male 6 weeks $29.80 Female 7 weeks $32.50 Female 8 weeks $35.20 Female 9 weeks $37.80 Female 10 weeks $40.50 Female
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Supply Details
| Standard Supply | Level 2. Up to 100 mice. Larger quantities or custom orders arranged upon request. |
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| Important Note | |
| This strain is homozygous for the retinal degeneration allele Pde6brd1. See article "Genetic Background Effects: Can Your Mice See?", JAX® NOTES Spring 2002, No. 485. | |
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