Strain Name: |
SJL/J |
|---|---|
Stock Number: |
000686 |
Availability: | Level 2 |
Price and Supply Information | |
General Terms and Conditions |
| Former Name |
SJL/J-Pde6brd1 (Changed: 19-MAR-08
) |
| Strain Common Names | Swiss Jim Lambert; |
| Genes & Alleles | Dysf; Dysfim; Pde6b; Pde6brd1; Rmcf; Rmcfs; |
Product Information
Strain Details
Type Inbred Strain Additional information on Inbred Strains. Mating System Sibling x Sibling (Female x Male) Species laboratory mouse H2 Haplotype s2 (see, Fischer Lindahl K 1997 and Shen FW 1982) Appearance
albino
Related Genotype: Oca2p Tyrc/Oca2p TyrcImportant Note
This strain is homozygous for the retinal degeneration allele Pde6brd1. See article "Genetic Background Effects: Can Your Mice See?", JAX Notes Spring 2002, No. 485.Strain Description
SJL mice display a very high incidence of reticulum cell sarcomas resembling Hodgkin's disease by approximately one year of age. Sarcomas first appear in the Peyer's patches and mesenteric lymph nodes and later in the spleen, liver, thymus and other lymph nodes. Most of the tumors are mixed-cell types classified as type B reticulum cell neoplasms, but a few are type A histiocytomas. This strain is also characterized by extreme aggression in males and its susceptibility to experimental autoimmune encephalomyelitis (EAE) for multiple sclerosis research. SJL/J mice develop a spontaneous myopathy resulting from a splice-site mutation in the Dysferlin gene. This Dysfim allele has been shown to result in decreased levels of dysferlin protein in SJL/J mice and makes this strain a good model for limb girdle muscular dystrophy 2B. This spontaneous myopathy is characterized by a progressive loss of muscle mass and strength corresponding with an increase in muscle pathology including muscle fibers with central nuclei, size variation, splitting, inflammatory infiltrate, necrosis, and eventual replacement of muscle fiber with fat. While muscle weakness can be detected as early as three weeks of age the greatest pathology occurs after 6 months of age. SJL/J mice have also been shown to have an increased rate of muscle regeneration after injury when compared to BALB/c mice.SJL mice, fed an atherogenic diet (1.25% cholesterol, 0.5% cholic acid and 15% fat), fail to develop atherosclerotic aortic lesions in contrast to several highly susceptible strains of mice (e.g. C57BL/6J, Stock No. 000664; C57L/J, Stock No. 000668, C57BR/cdJ, Stock No. 000667, and SM/J, Stock No. 000687). SJL/J are also useful as a control strain for studying immune defects in NOD/ShiLtJ mice (Stock No. 001976), a model for type 1 diabetes (IDDM). Both NOD and SJL/J are derived from Swiss mice; SJL are immunocompetent but have elevated levels of circulating T cells.
Strain Development
SJL mice were developed by James Lambert at The Jackson Laboratory in 1955 from three different sources of Swiss Webster mice.
Gene & Allele Details
| Allele Symbol | Dysfim | ||
|---|---|---|---|
| Allele Name | inflammatory myopathy | ||
| Common Name(s) | SJL-Dysf; | ||
| Strain of Origin | SJL | ||
| Gene Symbol and Name | Dysf, dysferlin | ||
| Chromosome | 6 | ||
| Gene Common Name(s) | 2310004N10Rik; AI604795; D6Pas3; DNA segment, Chr 6, Pasteur Institute 3; FER1L1; FLJ00175; FLJ90168; LGMD2B; RIKEN cDNA 2310004N10 gene; expressed sequence AI604795; | ||
| Molecular Note | A 171 bp in-frame deletion in the encoded mRNA is predicted to remove 57 amino acids from the corresponding protein. This region corresponds to most of the fourth C2 domain of the protein, and the deletion likely results in instability of the protein. The molecular basis for the mutation is due to a splicing mutation in the gene, resulting from a deletion of a small tandem repeat. [MGI Ref ID J:67994] | ||
| Allele Symbol | Pde6brd1 | ||
| Allele Name | retinal degeneration 1 | ||
| Common Name(s) | rd; rd-1; rd1; rodless retina; | ||
| Gene Symbol and Name | Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide | ||
| Chromosome | 5 | ||
| Gene Common Name(s) | CSNB3; PDEB; Pdeb; RP40; nmf137; phosphodiesterase, cGMP, rod receptor, beta polypeptide; r; rd; rd-1; rd1; rd10; retinal degeneration; retinal degeneration 1; retinal degeneration 10; | ||
| Molecular Note | Two mutations have been identified in rd1 mice. A murine leukimia virus (Xmv-28) insertion in reverse orientation in intron 1 is found in all mouse strains with the rd1 phenotype. Further, a nonsense mutation (C to A transversion) in codon 347 that results in a truncation eliminating more than half of the predicted encoded protein, including the catalytic domain has also been identified in all rd1 strains of mice. A specific degradation of mutant transcript during or after pre-mRNA splicing is suggested. [MGI Ref ID J:11513] [MGI Ref ID J:4366] [MGI Ref ID J:51361] | ||
| Allele Symbol | Rmcfs | ||
| Allele Name | MCF sensitive | ||
| Gene Symbol and Name | Rmcf, resistance to MCF virus | ||
| Chromosome | 5 | ||
Colony Maintenance
| Diet Information | LabDiet® 5K52/5K67 |
|---|
Related Strains
SJL Strains
001902 SJL/Bm View SJL Strains (1 strain)
000646 A/J 000648 AKR/J 000779 AKXD14/TyJ 000780 AKXD23/TyJ 000764 AKXD27/TyJ 000777 AKXD6/TyJ 000667 C57BR/cdJ 000668 C57L/J 000669 C58/J 000682 RF/J 000644 SEA/GnJ 000688 ST/bJ
006830 129-Dysftm1Kcam/J 000646 A/J
004297 B6.CXB1-Pde6brd10/J 002802 C3.BLiA Pde6b+-Krd/J 001979 C3A.BLiA-Pde6b+.O20-Prph2Rd2/J 001912 C3A.BLiA-Pde6b+/J 003648 C3Sn.BLiA-Pde6b+/Dn 004766 C57BL/6J-Pde6brd1-2J/J 004828 FVB.129P2-Pde6b+ Tyrc-ch/AntJ 004808 STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
000690 129P3/J 000765 AKXD13/TyJ 000954 AKXD15/TyJ 001093 AKXD18/TyJ 000947 AKXD22/TyJ 000763 AKXD9/TyJ 000654 CBA/CaJ 000670 DBA/1J
Phenotypic Data
Body Weight Information - JAX® Mice Strain SJL/J (000686)Mouse Phenome Database
(This chart reflects the typical correlation between body weight and age for mice maintained in production colonies at The Jackson Laboratory.)
Mouse Phenome Database - activity and motor function
Mouse Phenome Database - atherogenic diet
Mouse Phenome Database - body weight
Mouse Phenome Database - cardiovascular
Mouse Phenome Database - drinking preference
Mouse Phenome Database - food and water intake
Mouse Phenome Database - hematology
Mouse Phenome Database - hormones
Festing Inbred Strain Characteristics: SJL
Additional Web Information
Genetic Quality Control Annual Report
JAX® NOTES, April 1988; 433. H-2 Haplotypes of Mice from Jackson Laboratory Production Colonies.
JAX® NOTES, Spring 1990; 441. Imperforate Vagina and Mucometra in Mice.
JAX® NOTES, Spring 1999; 477. Control Strains for NOD/LtJ Mice in Diabetes Research.
JAX® NOTES, Spring 2002; 485. Genetic Background Effects: Can Your Mice See?
JAX® NOTES, Spring 2003; 489. Malocclusion in the Laboratory Mouse.
JAX® NOTES, Spring 2003; 489. Role of NK and NKT Cells in Immunity and Disease.
JAX® NOTES, Summer 1994; 458. Ly5 Gene Nomenclature, C57BL/6J and SJL/J - A History of Change.
JAX® NOTES, Summer 2003; 490. Hydrocephalus in Laboratory Mice.
Animal Health Reports
Room Number AX3
Room Number MP14
Room Number MP16
Research Applications
This mouse can be used to support research in many areas including:
Dysfim relatedCancer Research
Increased Tumor Incidence (Other Tissues/Organs: reticulum cell sarcomas, Hodgkin's disease)
Cardiovascular Research
Diet-Induced Atherosclerosis (Relatively Resistant)
Diabetes and Obesity Research
Type 1 Diabetes (IDDM) Analysis Strains (Related Inbred Strains)
Immunology and Inflammation Research
Autoimmunity (experimental allergic encephalomyelitis (EAE))
Neurobiology Research
Angelman syndrome
Research Tools
Immunology and Inflammation Research (NK Cell Deficiency)
Sensorineural Research
Retinal Degeneration (Homozygous for Pde6brd1)
Pde6brd1 relatedMouse/Human Gene Homologs
muscular dystrophy, limb-girdle (type 2B)
retinitis pigmentosa, autosomal recessive
Sensorineural Research
Retinal Degeneration
References
Selected Reference(s)
Additional ReferencesBittner RE; Anderson LV; Burkhardt E; Bashir R; Vafiadaki E; Ivanova S; Raffelsberger T; Maerk I; Hoger H; Jung M; Karbasiyan M; Storch M; Lassmann H; Moss JA; Davison K; Harrison R; Bushby KM; Reis A. 1999. Dysferlin deletion in SJL mice (SJL-Dysf) defines a natural model for limb girdle muscular dystrophy 2B [letter] Nat Genet 23(2):141-2. [PubMed: 10508505] [MGI Ref ID J:57764]
Crispens CG. 1973. Some characteristics of strain SJL-JDg mice. Lab Anim Sci 23(3):408-13. [PubMed: 4351481] [MGI Ref ID J:25445]
Dal Canto MC; Melvold RW; Kim BS; Miller SD. 1995. Two models of multiple sclerosis: experimental allergic encephalomyelitis (EAE) and Theiler's murine encephalomyelitis virus (TMEV) infection. A pathological and immunological comparison. Microsc Res Tech 32(3):215-29. [PubMed: 8527856] [MGI Ref ID J:109910]
Fischer Lindahl K. 1997. On naming H2 haplotypes: functional significance of MHC class Ib alleles. Immunogenetics 46(1):53-62. [PubMed: 9148789] [MGI Ref ID J:41130]
Fujinaga S; Poel WE; Williams WC; Dmochowski L. 1970. Biological and morphological studies of SJL-J strain reticulum cell neoplasms induced and transmitted serially in low-leukemia-strain mice. Cancer Res 30(3):729-42. [PubMed: 4316600] [MGI Ref ID J:25329]
McGeachie JK; Grounds MD. 1995. Retarded myogenic cell replication in regenerating skeletal muscles of old mice: an autoradiographic study in young and old BALBc and SJL/J mice. Cell Tissue Res 280(2):277-82. [PubMed: 7781025] [MGI Ref ID J:25692]
Mitchell CA; McGeachie JK; Grounds MD. 1992. Cellular differences in the regeneration of murine skeletal muscle: a quantitative histological study in SJL/J and BALB/c mice. Cell Tissue Res 269(1):159-66. [PubMed: 1423478] [MGI Ref ID J:2981]
Nishina PM; Wang J; Toyofuku W; Kuypers FA; Ishida BY; Paigen B. 1993. Atherosclerosis and plasma and liver lipids in nine inbred strains of mice. Lipids 28(7):599-605. [PubMed: 8355588] [MGI Ref ID J:13267]
Paigen B; Ishida BY; Verstuyft J; Winters RB; Albee D. 1990. Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice. Arteriosclerosis 10(2):316-23. [PubMed: 2317166] [MGI Ref ID J:22615]
Paigen B; Morrow A; Brandon C; Mitchell D; Holmes P. 1985. Variation in susceptibility to atherosclerosis among inbred strains of mice. Atherosclerosis 57(1):65-73. [PubMed: 3841001] [MGI Ref ID J:109950]
Shen FW; Chorney MJ; Boyse EA. 1982. Further polymorphism of the Tla locus defined by monoclonal TL antibodies. Immunogenetics 15(6):573-8. [PubMed: 7106865] [MGI Ref ID J:6828]
Vafiadaki E; Reis A; Keers S; Harrison R; Anderson LV; Raffelsberger T; Ivanova S; Hoger H; Bittner RE; Bushby K; Bashir R. 2001. Cloning of the mouse dysferlin gene and genomic characterization of the SJL-Dysf mutation. Neuroreport 12(3):625-9. [PubMed: 11234777] [MGI Ref ID J:67994]
Weller AH; Magliato SA; Bell KP; Rosenberg NL. 1997. Spontaneous myopathy in the SJL/J mouse: pathology and strength loss. Muscle Nerve 20(1):72-82. [PubMed: 8995586] [MGI Ref ID J:38007]
Price and Supply Information
| Strain Name: | SJL/J |
| Stock Number: | 000686 |
Price Details
IMPORTANT NOTE: Prices are based on shipping destination. The shipping destinations are:
- USA, Canada and Mexico
- International
*Pricing for Shipping Destination selected:
USA, Canada and Mexico
| Price(s) in US dollars ($) | Genotype(s) Provided | ||||
|---|---|---|---|---|---|
| 3 weeks | $19.75 | Female | |||
| 4 weeks | $19.75 | Female | |||
| 5 weeks | $20.00 | Female | |||
| 6 weeks | $21.75 | Female | |||
| 7 weeks | $23.75 | Female | |||
| 8 weeks | $25.75 | Female | |||
| 9 weeks | $27.65 | Female | |||
| 10 weeks | $29.60 | Female | |||
| 3 weeks | $18.75 | Male | |||
| 4 weeks | $18.75 | Male | |||
| 5 weeks | $18.75 | Male | |||
Supply Details
| Standard Supply | Level 2. Up to 100 mice. Larger quantities or custom orders arranged upon request. |
|---|---|
| Supply Notes |
Histology and Tissue Collection Services are available for all JAX® Mice strains. For more information, please contact Customer Service at orderquest@jax.org or 1-800-422-6423. Males not available after five weeks of age. Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available. Strains that must be genotyped are not available until five to seven weeks of age. Genomic DNA is available for this strain from the Mouse DNA Resource. |
| Licensing | See General Terms and Conditions below |
General Terms and Conditions
View JAX® Mice & Services Conditions of Use.
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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