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- Genes & alleles
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Description
Strain Information
Former Names SWR/J-Pde6brd1 (Changed: 19-MAR-08 ) Type Inbred Strain; Additional information on Inbred Strains. Visit our online Nomenclature tutorial. Mating System Sibling x Sibling (Female x Male) 01-MAR-06 Breeding Considerations This strain is a good breeder. Species laboratory mouse H2 Haplotype q2 (see, Fischer Lindahl K 1997 and Shen FW 1982) Generation F245 (17-SEP-12)
Generation Definitions
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albino
Related Genotype: A/A Tyrc/TyrcImportant Note
This strain is homozygous for the retinal degeneration allele Pde6brd1. See article "Genetic Background Effects: Can Your Mice See?", JAX® NOTES Spring 2002, No. 485.Description
SWR/J mice are used widely in research as a general purpose strain. Aging mice exhibit a high incidence of lung and mammary gland tumors. They also develop extreme polydipsia and polyuria (nephrogenic diabetes insipidus) with increasing age. SWR/J mice are highly susceptible to experimental allergic encephalomyelitis (EAE). Germline deletion of about 50% of T-cell receptor V beta-chain gene segments and a T-cell receptor V alpha polymorphism are responsible for the resistance of SWR/J mice to collagen type II-induced arthritis. SWR/J mice show an intermediate susceptibility to developing atherosclerotic aortic lesions (1670 to 1690 um2 atherosclerotic aortic lesions/aortic cross-section) following 14 weeks on an atherogenic diet (1.25% cholesterol, 0.5% cholic acid and 15% fat). SWR/J mice have been recommended for generation and propogation of transgenic mice because they are high responders to exogenous hormones, have large and prominant pronuclei with good resistance to lysis following microinjection, and are genetically well-defined. SWR/J mice may also be used as controls for comparison to the autoimmune diabetic NOD/ShiLtJ mice (Stock No. 001976), especially for experiments examining the aberrant immune functions of NOD/ShiLtJ mice. Both NOD and SWR/J mice are derived from Swiss mice. SWR/J are in some cases more suitable than random bred Swiss ICR mice because of their genetic uniformity. Unlike NOD/ShiLtJ mice they are not immunocompromised, and they are genetically very different from NOD. SWR/J mice appear to be the only inbred carrying the allele Soaa (Taster) characterized by avoidance of sucrose octaacetate solutions at low concentrations (< 10-3M).Development
The SWR inbred strain was developed by Clara J Lynch at The Rockefeller Institute who obtained swiss mice from A. de Coulon of Lausanne, Switzerland and began inbreeding around 1926. This strain was transferred to Raymond Parker at the University of Toronto who supplied them to The Jackson Laboratory in 1947 at F28+. In 1996 embryos were cryopreserved when this strain was at inbreeding generation F191.
Related Strains
Strains carrying Ahrd allele
000690 129P3/J 000648 AKR/J 008599 B6.Cg-Cyp1a2/Cyp1a1tm2Dwn Ahrd Tg(CYP1A1,CYP1A2)1Dwn/DwnJ 002921 B6.D2N-Ahrd/J 000652 BDP/J 000928 CAST/EiJ 000671 DBA/2J 000674 I/LnJ 000675 LG/J 000676 LP/J 000684 NZB/BlNJ 000726 RBF/DnJ 000682 RF/J 000686 SJL/J 000688 ST/bJ 000693 WC/ReJ KitlSl/J 000933 YBR/EiJ View Strains carrying Ahrd (17 strains)
001137 129P1/ReJ 000690 129P3/J 001198 129P4/RrRkJ 002448 129S1/SvImJ 002064 129T2/SvEms 002065 129T2/SvEmsJ 000691 129X1/SvJ 002282 BTBR T+ Itpr3tf/J 002243 DDY/JclSidSeyFrkJ 001800 FVB/NJ 000676 LP/J 000686 SJL/J
000645 A/HeJ 000646 A/J 000647 A/WySnJ 000648 AKR/J 000460 B10.D2-Hc0 H2d H2-T18c/o2SnJ 000461 B10.D2-Hc0 H2d H2-T18c/oSnJ 000657 CE/J 000671 DBA/2J 007048 DBA/2J-Gpnmb+/SjJ 001800 FVB/NJ 001491 FVB/NMob 000674 I/LnJ 001303 NOD.CB17-Prkdcscid/J 001976 NOD/ShiLtJ 000684 NZB/BlNJ 000682 RF/J 000688 ST/bJ
000645 A/HeJ 000646 A/J 002920 B6(D2N).Spretus-Ahrb-3/J 006203 B6.129(FVB)-Ahrtm3.1Bra/J 002831 B6.129-Ahrtm1Bra/J 000130 B6.C-H17c/(HW14)ByJ 000136 B6.C-H34c/(HW22)ByJ 000370 B6.C-H38c/(HW119)ByJ 002727 B6;129-Ahrtm1Bra/J 001026 BALB/cByJ 000653 BUB/BnJ 000659 C3H/HeJ 000663 C57BL/6By 001139 C57BL/6ByJ 000664 C57BL/6J 000662 C57BLKS/J 000667 C57BR/cdJ 000668 C57L/J 000669 C58/J 000926 CAROLI/EiJ 000656 CBA/J 000657 CE/J 000351 CXB1/ByJ 000352 CXB2/ByJ 000353 CXB3/ByJ 000354 CXB4/ByJ 000355 CXB5/ByJ 000356 CXB6/ByJ 000357 CXB7/ByJ 002937 D2.B6-Ahrb-1/J 000673 HRS/J 000677 MA/MyJ 000550 MOLF/EiJ 000679 P/J 000930 PERA/EiJ 000644 SEA/GnJ 000280 SF/CamEiJ 001146 SPRET/EiJ
000470 AK.M-H2m H2-T18a/nSnJ 005308 B10.Cg-H2d Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ 000463 B10.D2-Hc1 H2d H2-T18c/nSnJ 003147 B10.D2-Hc1 H2d H2-T18c/nSnJ-Tg(DO11.10)10Dlo/J 004306 NOD.CBALs-Hc1/LtJ
004297 B6.CXB1-Pde6brd10/J 005252 B6EiC3Sn.BLiA-Ts(1716)65Dn/DnJ 003647 B6EiC3Sn.BLiAF1/J 002802 C3.BLiA Pde6b+-Krd/J 001912 C3A.BLiA-Pde6b+/J 001979 C3A.Cg-Pde6b+ Prph2Rd2/J 003648 C3Sn.BLiA-Pde6b+/DnJ 004766 C57BL/6J-Pde6brd1-2J/J 004624 FVB.129P2-Pde6b+ Tyrc-ch Fmr1tm1Cgr/J 004828 FVB.129P2-Pde6b+ Tyrc-ch/AntJ 004808 STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
Additional Web Information
JAX® NOTES, April 1988; 433. H-2 Haplotypes of Mice from Jackson Laboratory Production Colonies.
JAX® NOTES, Spring 1999; 477. Control Strains for NOD/LtJ Mice in Diabetes Research.
JAX® NOTES, Spring 2002; 485. Genetic Background Effects: Can Your Mice See?
Phenotype
Phenotype Information
Mouse Phenome Database
Festing Inbred Strain Characteristics: SWR
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested. Complement Component 5 Deficiency; C5D (C5)
Night Blindness, Congenital Stationary, Autosomal Dominant 2; CSNBAD2 (PDE6B)
Retinitis Pigmentosa 40; RP40 (PDE6B)
Schizophrenia 9; SCZD9 (DISC1)
Schizophrenia; SCZD (DISC1)
This mouse can be used to support research in many areas including:
Ahrd relatedCancer Research
Increased Tumor Incidence
Mammary Gland Tumors
Other Tissues/Organs
Other Tissues/Organs: lung
Cardiovascular Research
Diet-Induced Atherosclerosis
Susceptible
Developmental Biology Research
Lymphoid Tissue Defects
hematopoietic defects
Diabetes and Obesity Research
Type 1 Diabetes (IDDM) Analysis Strains
Related Inbred Strains
Immunology, Inflammation and Autoimmunity Research
Autoimmunity
experimental allergic encephalomyelitis (EAE)
Immunodeficiency
specific complement deficiency
Research Tools
General Purpose
Immunology and Inflammation Research
specific complement deficiency, C5 complement
Sensorineural Research
Retinal Degeneration
Homozygous for Pde6brd1
Hc0 relatedResearch Tools
Toxicology Research
Pde6brd1 relatedImmunology, Inflammation and Autoimmunity Research
Immunodeficiency
specific complement deficiency
Research Tools
Immunology and Inflammation Research
specific complement deficiency, C5 complement
Mouse/Human Gene Homologs
retinitis pigmentosa, autosomal recessive
Sensorineural Research
Retinal Degeneration
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Ahrd | ||
|---|---|---|---|
| Allele Name | d variant | ||
| Allele Type | Not Applicable | ||
| Common Name(s) | Ahd; Ahk; AhRd; Ahhn; ah; in; | ||
| Gene Symbol and Name | Ahr, aryl-hydrocarbon receptor | ||
| Chromosome | 12 | ||
| Gene Common Name(s) | Ah; Ahh; Ahre; In; aromatic hydrocarbon responsiveness; aryl hydrocarbon hydroxylase; bHLHe76; dioxin receptor; inflammatory reactivity; | ||
| General Note |
Compared with Ahrd/Ahrd mice, Ahrb/Ahrb individuals have a high inflammatory response to cutaneous application of dimethylbenzanthracene; a high susceptibility to methylcholanthrene- and benzopyrene-induced subcutaneous sarcomas and methylcholanthrene-induced lung tumors; an increased resistance to zoxazolamine-induced paralysis, lindane toxicity, and benzo[a]pyrene-induced aplastic anemia and leukemia; a high susceptibility to acetaminophen-induced hepatic necrosis and cataract formation; and an increased susceptibility to polycyclic hydrocarbon-induced birth defects, stillbirths, resorptions, decreased body weight, ovarian primordial oocyte depletion, and spermatozoal aberrations (J:5822). The Ahrballele is associated with increases in numerous metabolites of chemical carcinogens binding to DNA nucleotides (J:12156). The effectiveness of several mutagens for Salmonella in vitro is enhanced by presence of a liver fraction from Ahrb/Ahrb> mice treated with polycyclic hydrocarbons, but not from similarly treated Ahrd/Ahr Strain of origin - this allele was found in DBA/2J, AKR/J, 129, SWR, RF, NZB strains | ||
| Molecular Note | This allele encodes a 104 kDa receptor that is stabilized by molybdate and has an affinity for ligand 10-100 fold lower than that of the receptor produced by the C57BL/6J allele. PCR sequencing of cDNA revealed ten nucleotide differences between the coding sequences of the DBA/2J and C57BL/6J receptors. Five of the ten differences would cause amino acid changes. One of these, an apparent T to C transition replaces the opal termination codon in the C57BL/6J allele with an arginine codon in the DBA/2J allele. This change would extend translation of the DBA/2J mRNA by 43 amino acids, accounting for the larger size of the peptide produced by this allele (104 kDa vs 95 kDa for the C57BL/6J allele). A second T to C transition changes a leucine codon in the C57BL/6J allele to a proline codon in the DBA/2J allele, and would likely change secondary structure of the peptide and thus ligand affinity. [MGI Ref ID J:15153] [MGI Ref ID J:17460] [MGI Ref ID J:22144] | ||
| Allele Symbol | Disc1del | ||
| Allele Name | deletion | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | Disc1129S6; Disc1delta6; | ||
| Strain of Origin | various | ||
| Gene Symbol and Name | Disc1, disrupted in schizophrenia 1 | ||
| Chromosome | 8 | ||
| Gene Common Name(s) | C1orf136; SCZD9; | ||
| General Note | This deletion appears in multiple strains of the 129 superfamily, 101/RI, BTBR T+ tf/J, LP/J, FVB/NJ, SJL/J, SWR/J and DDY/JclSidSeyFrkJ (J:111837, J:195189). | ||
| Molecular Note | A 25 bp deletion of the locus causes a frame shift in the reading frame, resulting in 13 novel amino acids and a premature stop codon at exon 7. [MGI Ref ID J:107244] | ||
| Allele Symbol | Hc0 | ||
| Allele Name | deficient | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | C5-; C5-d; C5-def; C5-deficient; hco; | ||
| Strain of Origin | multiple strains | ||
| Gene Symbol and Name | Hc, hemolytic complement | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | C5; C5a; C5b; CPAMD4; He; RGD1561905; | ||
| General Note |
This is an allele characteristic of various inbred mouse strains including the following: A/HeJ, AKR/J, DBA/2J, NZB/B1NJ, SWR/J, B10.D2/oSnJ Hc was identified as a candidate gene for Abhr2 in a microarray analysis of lung mRNA from A/J, C3H/HeJ, and (A/J x C3H/HeJ)F1 x A/J backcross animals. Hc genotype shows statistically significant correlation to allergen-induced bronchial hyperresponsive phenotype. The A/J allele contains a 2 bp deletion resulting in deficient Hc mRNA and protein production and is associated with susceptibility to allergen-induced bronchial hyperresponsiveness. (J:108211) | ||
| Molecular Note | A 2 base "TA" deletion at positions 62 and 63 of an 83 base pair exon near the 5' end of the gene is found in the following mouse strains: A/HeJ, AKR/J, DBA/2J, NZB/B1NJ, SWR/J, B10.D2/oSnJ. The consequence of this deletion is the creation of a stop codon starting four bases after the deletion. A truncated product of 216 amino acids is predicted as a result although contradictory reports exist that a larger pro-C5 protein may be synthesized. Nevertheless, macrophages from mouse strains carrying this allele do not secrete complement 5. [MGI Ref ID J:23983] [MGI Ref ID J:5016] | ||
| Allele Symbol | Pde6brd1 | ||
| Allele Name | retinal degeneration 1 | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | Pdebrd1; rd; rd-1; rd1; rodless retina; | ||
| Strain of Origin | various | ||
| Gene Symbol and Name | Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide | ||
| Chromosome | 5 | ||
| Gene Common Name(s) | CSNB3; CSNBAD2; PDEB; Pdeb; RP40; nmf137; phosphodiesterase, cGMP, rod receptor, beta polypeptide; r; rd; rd-1; rd1; rd10; retinal degeneration; retinal degeneration 1; retinal degeneration 10; | ||
| General Note |
The following inbred strains are known to be homozygous for Pde6b | ||
| Molecular Note | Two mutations have been identified in rd1 mice. A murine leukimia virus (Xmv-28) insertion in reverse orientation in intron 1 is found in all mouse strains with the rd1 phenotype. Further, a nonsense mutation (C to A transversion) in codon 347 that results in a truncation eliminating more than half of the predicted encoded protein, including the catalytic domain has also been identified in all rd1 strains of mice. A specific degradation of mutant transcript during or after pre-mRNA splicing is suggested. [MGI Ref ID J:11513] [MGI Ref ID J:4366] [MGI Ref ID J:51361] | ||
Genotyping
Genotyping Information
Inbred mouse strains are maintained through sibling (sister x brother) matings; no genotyping required.
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Deringer MK. 1970. Mammary tumors in strains BL-LyDe and SWR-LyDe mice. J Natl Cancer Inst 45(2):215-8. [PubMed: 4324608] [MGI Ref ID J:69927]
Fischer Lindahl K. 1997. On naming H2 haplotypes: functional significance of MHC class Ib alleles. Immunogenetics 46(1):53-62. [PubMed: 9148789] [MGI Ref ID J:41130]
Jiao S; Cole TG; Kitchens RT; Pfleger B; Schonfeld G. 1990. Genetic heterogeneity of plasma lipoproteins in the mouse: control of low density lipoprotein particle sizes by genetic factors. J Lipid Res 31(3):467-77. [PubMed: 1971301] [MGI Ref ID J:15484]
Kirk EA; Moe GL; Caldwell MT; Lernmark JA; Wilson DL; LeBoeuf RC. 1995. Hyper- and hypo-responsiveness to dietary fat and cholesterol among inbred mice: searching for level and variability genes. J Lipid Res 36(7):1522-32. [PubMed: 7595076] [MGI Ref ID J:28648]
Kutscher CL; Miller DG. 1974. Age-dependent polydipsia in the SWR-J mouse. Physiol Behav 13(1):71-9. [PubMed: 4850464] [MGI Ref ID J:33646]
Kutscher CL; Miller M; Schmalbach NL. 1975. Renal deficiency associated with diabetes insipidus in the SWR/J mouse. Physiol Behav 14(6):815-8. [PubMed: 1187837] [MGI Ref ID J:25303]
Kutscher CL; Schmalbach NL. 1975. Effects of water deprivation, NaCl injection, and seven aversive taste stimuli on drinking in two normal mouse strains and one with diabetes insipidus. Physiol Behav 15(6):659-67. [PubMed: 1226406] [MGI Ref ID J:25302]
Levine S; Sowinski R. 1973. Experimental allergic encephalomyelitis in inbred and outbred mice. J Immunol 110(1):139-43. [PubMed: 4631068] [MGI Ref ID J:24660]
Lindsey JW. 1996. Characteristics of initial and reinduced experimental autoimmune encephalomyelitis. Immunogenetics 44(4):292-7. [PubMed: 8753860] [MGI Ref ID J:35147]
Lynch CJ. 1969. The so-called Swiss mouse. Lab Anim Care 19(2):214-20. [PubMed: 4240230] [MGI Ref ID J:24849]
Nishina PM; Wang J; Toyofuku W; Kuypers FA; Ishida BY; Paigen B. 1993. Atherosclerosis and plasma and liver lipids in nine inbred strains of mice. Lipids 28(7):599-605. [PubMed: 8355588] [MGI Ref ID J:13267]
Ortman RA; Holderbaum D; Qu XM; Banerjee S; Haqqi TM. 1994. BUB/BnJ (H-2q) is a TCR deletion mutant mouse strain (TCR V beta a, KJ16-) that is susceptible to type II collagen-induced arthritis. J Immunol 152(8):4175-82. [PubMed: 8144978] [MGI Ref ID J:17601]
Osman GE; Hannibal MC; Anderson JP; Cheunsuk S; Lasky SR; Liggitt HD; Ladiges WC; Hood LE. 1999. T-cell receptor vbeta deletion and valpha polymorphism are responsible for the resistance of SWR mouse to arthritis induction. Immunogenetics 49(9):764-72. [PubMed: 10398803] [MGI Ref ID J:109896]
Osman GE; Jacobson DP; Li SW; Hood LE; Liggitt HD; Ladiges WC. 1997. SWR: an inbred strain suitable for generating transgenic mice. Lab Anim Sci 47(2):167-71. [PubMed: 9150496] [MGI Ref ID J:40533]
Paigen B. 1995. Genetics of responsiveness to high-fat and high- cholesterol diets in the mouse. Am J Clin Nutr 62(2):458S-462S. [PubMed: 7625360] [MGI Ref ID J:28248]
Paigen B; Ishida BY; Verstuyft J; Winters RB; Albee D. 1990. Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice. Arteriosclerosis 10(2):316-23. [PubMed: 2317166] [MGI Ref ID J:22615]
Paigen B; Morrow A; Brandon C; Mitchell D; Holmes P. 1985. Variation in susceptibility to atherosclerosis among inbred strains of mice. Atherosclerosis 57(1):65-73. [PubMed: 3841001] [MGI Ref ID J:109950]
Serreze DV; Leiter EH. 1988. Defective activation of T suppressor cell function in nonobese diabetic mice. Potential relation to cytokine deficiencies. J Immunol 140(11):3801-7. [PubMed: 2897395] [MGI Ref ID J:27617]
Shen FW; Chorney MJ; Boyse EA. 1982. Further polymorphism of the Tla locus defined by monoclonal TL antibodies. Immunogenetics 15(6):573-8. [PubMed: 7106865] [MGI Ref ID J:6828]
Additional References
Beamer WG; Hoppe PC; Whitten WK. 1985. Spontaneous malignant granulosa cell tumors in ovaries of young SWR mice. Cancer Res 45(11 Pt 2):5575-81. [PubMed: 4053032] [MGI Ref ID J:34553]
DiPetrillo K; Tsaih SW; Sheehan S; Johns C; Kelmenson P; Gavras H; Churchill GA; Paigen B. 2004. Genetic analysis of blood pressure in C3H/HeJ and SWR/J mice. Physiol Genomics 17(2):215-20. [PubMed: 14996992] [MGI Ref ID J:89267]
Eberhart GP; West DB; Boozer CN; Atkinson RL. 1994. Insulin sensitivity of adipocytes from inbred mouse strains resistant or sensitive to diet-induced obesity. Am J Physiol 266(5 Pt 2):R1423-8. [PubMed: 8203615] [MGI Ref ID J:18464]
International Nomenclature Committee. 1952. COMMITTEE on Standardized Nomenclature for Inbred Strains of Mice Cancer Res 12(8):602-13. [PubMed: 14945054] [MGI Ref ID J:166288]
Moy SS; Nadler JJ; Young NB; Nonneman RJ; Segall SK; Andrade GM; Crawley JN; Magnuson TR. 2008. Social approach and repetitive behavior in eleven inbred mouse strains. Behav Brain Res 191(1):118-29. [PubMed: 18440079] [MGI Ref ID J:138681]
Nilsson UR; Muller-Eberhard HJ. 1967. Deficiency of the fifth component of complement in mice with an inherited complement defect. J Exp Med 125(1):1-16. [PubMed: 4959665] [MGI Ref ID J:5016]
Ooi YM; Colten HR. 1979. Genetic defect in secretion of complement C5 in mice. Nature 282(5735):207-8. [PubMed: 492335] [MGI Ref ID J:6214]
Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11. [PubMed: 15081119] [MGI Ref ID J:89298]
Poland A; Glover E. 1990. Characterization and strain distribution pattern of the murine Ah receptor specified by the Ahd and Ahb-3 alleles. Mol Pharmacol 38(3):306-12. [PubMed: 2169579] [MGI Ref ID J:34840]
Smith BK; Andrews PK; West DB. 2000. Macronutrient diet selection in thirteen mouse strains. Am J Physiol Regul Integr Comp Physiol 278(4):R797-805. [PubMed: 10749765] [MGI Ref ID J:61602]
Smith BK; West DB; York DA. 1997. Carbohydrate versus fat intake: differing patterns of macronutrient selection in two inbred mouse strains. Am J Physiol 272(1 Pt 2):R357-62. [PubMed: 9039029] [MGI Ref ID J:39025]
West DB; Boozer CN; Moody DL; Atkinson RL. 1992. Dietary obesity in nine inbred mouse strains. Am J Physiol 262(6 Pt 2):R1025-32. [PubMed: 1621856] [MGI Ref ID J:1348]
West DB; Goudey-Lefevre J; York B; Truett GE. 1994. Dietary obesity linked to genetic loci on chromosomes 9 and 15 in a polygenic mouse model. J Clin Invest 94(4):1410-6. [PubMed: 7929816] [MGI Ref ID J:20700]
West DB; Waguespack J; McCollister S. 1995. Dietary obesity in the mouse: interaction of strain with diet composition. Am J Physiol 268(3 Pt 2):R658-65. [PubMed: 7900908] [MGI Ref ID J:24480]
West DB; Waguespack J; York B; Goudey-Lefevre J; Price RA. 1994. Genetics of dietary obesity in AKR/J x SWR/J mice: segregation of the trait and identification of a linked locus on chromosome 4. Mamm Genome 5(9):546-52. [PubMed: 8000138] [MGI Ref ID J:20129]
Wetsel RA; Fleischer DT; Haviland DL. 1990. Deficiency of the murine fifth complement component (C5). A 2-base pair gene deletion in a 5'-exon. J Biol Chem 265(5):2435-40. [PubMed: 2303408] [MGI Ref ID J:23983]
Wheat WH; Wetsel R; Falus A; Tack BF; Strunk RC. 1987. The fifth component of complement (C5) in the mouse. Analysis of the molecular basis for deficiency. J Exp Med 165(5):1442-7. [PubMed: 3572304] [MGI Ref ID J:8690]
Xie C; Sharma R; Wang H; Zhou XJ; Mohan C. 2004. Strain distribution pattern of susceptibility to immune-mediated nephritis. J Immunol 172(8):5047-55. [PubMed: 15067087] [MGI Ref ID J:122988]
Ahrd relatedDisc1del relatedBenedict WF; Considine N; Nebert DW. 1973. Genetic differences in aryl hydrocarbon hydroxylase induction and benzo(a)pyrene-produced tumorigenesis in the mouse. Mol Pharmacol 9(2):266-77. [PubMed: 4123113] [MGI Ref ID J:84312]
Boobis AR; Nebert DW. 1976. Genetic differences in the metabolism of carcinogens and in the binding of benzo (a) pyrene metabolites to DNA. Adv Enzyme Regul 15:339-62. [PubMed: 1030186] [MGI Ref ID J:12156]
Castro DJ; Lohr CV; Fischer KA; Pereira CB; Williams DE. 2008. Lymphoma and lung cancer in offspring born to pregnant mice dosed with dibenzo[a,l]pyrene: the importance of in utero vs. lactational exposure. Toxicol Appl Pharmacol 233(3):454-8. [PubMed: 18848954] [MGI Ref ID J:143604]
Chang C; Smith DR; Prasad VS; Sidman CL; Nebert DW; Puga A. 1993. Ten nucleotide differences, five of which cause amino acid changes, are associated with the Ah receptor locus polymorphism of C57BL/6 and DBA/2 mice. Pharmacogenetics 3(6):312-21. [PubMed: 8148872] [MGI Ref ID J:17460]
Curran CP; Miller KA; Dalton TP; Vorhees CV; Miller ML; Shertzer HG; Nebert DW. 2006. Genetic differences in lethality of newborn mice treated in utero with coplanar versus non-coplanar hexabromobiphenyl. Toxicol Sci 89(2):454-64. [PubMed: 16291824] [MGI Ref ID J:113285]
Felton JS; Nebert DW. 1975. Mutagenesis of certain activated carcinogens in vitro associated with genetically mediated increases in monooxygenase activity and cytochrome P 1-450. J Biol Chem 250(17):6769-78. [PubMed: 808546] [MGI Ref ID J:5564]
Gielen JE; Goujon FM; Nebert DW. 1972. Genetic regulation of aryl hydrocarbon hydroxylase induction. II. Simple Mendelian expression in mouse tissues in vivo. J Biol Chem 247(4):1125-37. [PubMed: 4110756] [MGI Ref ID J:84250]
Goujon FM; Nebert DW; Gielen JE. 1972. Genetic expression of aryl hydrocarbon hydroxylase induction. IV. Interaction of various compounds with different forms of cytochrome P-450 and the effect on benzo(a)pyrene metabolism in vitro. Mol Pharmacol 8(6):667-80. [PubMed: 4118365] [MGI Ref ID J:84252]
Harper PA; Golas CL; Okey AB. 1991. Ah receptor in mice genetically nonresponsive for cytochrome P4501A1 induction: cytosolic Ah receptor, transformation to the nuclear binding state, and induction of aryl hydrocarbon hydroxylase by halogenated and nonhalogenated aromatic hydrocarbons in embryonic tissues and cells. Mol Pharmacol 40(5):818-26. [PubMed: 1658612] [MGI Ref ID J:2134]
Kerley-Hamilton JS; Trask HW; Ridley CJ; Dufour E; Lesseur C; Ringelberg CS; Moodie KL; Shipman SL; Korc M; Gui J; Shworak NW; Tomlinson CR. 2012. Inherent and benzo[a]pyrene-induced differential aryl hydrocarbon receptor signaling greatly affects life span, atherosclerosis, cardiac gene expression, and body and heart growth in mice. Toxicol Sci 126(2):391-404. [PubMed: 22228805] [MGI Ref ID J:183715]
Kouri RE; Rude TH; Joglekar R; Dansette PM; Jerina DM; Atlas SA; Owens IS; Nebert DW. 1978. 2,3,7,8-tetrachlorodibenzo-p-dioxin as cocarcinogen causing 3-methylcholanthrene-initiated subcutaneous tumors in mice genetically 'nonresponsive' at Ah locus. Cancer Res 38(9):2777-83. [PubMed: 679184] [MGI Ref ID J:84318]
Levova K; Moserova M; Nebert DW; Phillips DH; Frei E; Schmeiser HH; Arlt VM; Stiborova M. 2012. NAD(P)H:quinone oxidoreductase expression in Cyp1a-knockout and CYP1A-humanized mouse lines and its effect on bioactivation of the carcinogen aristolochic acid I. Toxicol Appl Pharmacol 265(3):360-7. [PubMed: 22982977] [MGI Ref ID J:192865]
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Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX6
Room Number MP19
Colony Maintenance
Mating System Sibling x Sibling (Female x Male) 01-MAR-06 Breeding Considerations This strain is a good breeder. Diet Information LabDiet® 5K52/5K67
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
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Standard Supply
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Standard Supply
Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.
Supply Notes
- Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
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Standard Supply
Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Important Note
This strain is homozygous for the retinal degeneration allele Pde6brd1. See article "Genetic Background Effects: Can Your Mice See?", JAX® NOTES Spring 2002, No. 485.
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