Strain Name:

WB/ReJ KitW/J

Stock Number:

000692

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Availability:

Level 4

Kit mice possess pleiotropic defects in pigment-forming cells, germ cells, RBC's and mast cells. In addition, they exhibit impaired resistance to parasitic infection and an intrinsic progenitor cell defect. The lack of germ cells in homozygous mutant mice leads to the development of some ovarian tumors (mesotheliomas and granulosa cell), associated with an overproduction of pituitary gonadotropic hormone. Kit mice generally have a well-defined belly spot with sharp edges and a very variable amount of white in the dorsal coat.

Description

Strain Information

Type Segregating Inbred;
Type Mutant Strain; Spontaneous Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Mating SystemHeterozygote x +/+ sibling         (Female x Male)   27-NOV-07
Mating System+/+ sibling x Heterozygote         (Female x Male)   27-NOV-07
Breeding Considerations This strain is a good breeder.
Specieslaboratory mouse
H2 Haplotypej
GenerationF202 (05-AUG-14)
Generation Definitions

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Appearance
diluted black with white belly spot, occasionally has white head blaze, tail has white tip, affected
Related Genotype: a/a KitW/+

non-diluted black, frequently have small belly spots, unaffected
Related Genotype: a/a +/+

Important Note
This strain is homozygous for the retinal degeneration allele Pde6brd1. See article "Genetic Background Effects: Can Your Mice See?", JAX® NOTES Spring 2002, No. 485.

Description
Kit mice possess pleiotropic defects in pigment-forming cells, germ cells, RBC's and mast cells. In addition, they exhibit impaired resistance to parasitic infection and an intrinsic progenitor cell defect. The lack of germ cells in homozygous mutant mice leads to the development of some ovarian tumors (mesotheliomas and granulosa cell), associated with an overproduction of pituitary gonadotropic hormone.

Development
Mice carrying the KitW mutation were sent from Dr. S. J. Holman and Dr. Salome Waelsch to Elizabeth Russell at The Jackson Laboratory in the late 1940?s. Female #168 was bred with male #169 to begin the generation of inbred lines segregating for KitW and the resulting inbred lines were selected for frequency and longevity of homozygotes. The lines were maintained by full sibling inbreeding and line WB separated from WC at generation F8. Prior to F25 homozygotes on the WB background showed an average lifespan of 10.6 days. Additionally, the mean age of first litter at that time, 75 days, was earlier than that of WC, which was 92 days of age (Russell and McFarland, 1966). In 1960 WB/Re reached generation F36, in 1965 F56, in 1975 F97, in 1986 F126, in 1992 F138, and in 2010 F191. Embryos were cryopreserved in 1987.

Control Information

  Control
   Wild-type from the colony
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   KitW allele
000164   B6.Cg-KitW/J
000092   FL/1Re-KitW/J
100410   WBB6F1/J-KitW/KitW-v/J
View Strains carrying   KitW     (3 strains)

Strains carrying   Pde6brd1 allele
004202   B6.C3 Pde6brd1 Hps4le/+ +-Lmx1adr-8J/J
000002   B6.C3-Pde6brd1 Hps4le/J
001022   B6C3FeF1/J a/a
000652   BDP/J
000653   BUB/BnJ
002439   C3.129P2(B6)-B2mtm1Unc/J
005494   C3.129S1(B6)-Grm1rcw/J
000509   C3.Cg-Lystbg-2J/J
000480   C3.MRL-Faslpr/J
001957   C3A Pde6brd1.O20/A-Prph2Rd2/J
004326   C3Bir.129P2(B6)-Il10tm1Cgn/Lt
003968   C3Bir.129P2(B6)-Il10tm1Cgn/LtJ
006435   C3Fe.SW-Soaa/MonJ
001904   C3H-Atcayji-hes/J
000659   C3H/HeJ
000511   C3H/HeJ-Ap3d1mh-2J/J
000784   C3H/HeJ-Faslgld/J
002433   C3H/HeJ-Sptbn4qv-lnd2J/J
005972   C3H/HeJBirLtJ
001824   C3H/HeJSxJ
000635   C3H/HeOuJ
000474   C3H/HeSn
001431   C3H/HeSn-ocd/J
000661   C3H/HeSnJ
002333   C3H/HeSnJ-gri/J
001576   C3He-Atp7btx-J/J
000658   C3HeB/FeJ
002588   C3HeB/FeJ-Eya1bor/J
001533   C3HeB/FeJ-Mc1rE-so Gli3Xt-J/J
001908   C3HfB/BiJ
001502   C3Sn.B6-Epha4rb/EiGrsrJ
002235   C3Sn.C3-Ctnna2cdf/J
001547   C3Sn.Cg-Cm/J
001906   C3fBAnl.Cg-Catb/AnlJ
000656   CBA/J
000813   CBA/J-Atp7aMo-pew/J
000660   DA/HuSnJ
000023   FL/1ReJ
000025   FL/4ReJ
003024   FVB.129P2(B6)-Fmr1tm1Cgr/J
002539   FVB.129P2-Abcb4tm1Bor/J
002935   FVB.129S2(B6)-Ccnd1tm1Wbg/J
002953   FVB.Cg-Tg(MMTVTGFA)254Rjc/J
003170   FVB.Cg-Tg(Myh6-tTA)6Smbf/J
003078   FVB.Cg-Tg(WapIgf1)39Dlr/J
003487   FVB.Cg-Tg(XGFAP-lacZ)3Mes/J
003257   FVB/N-Tg(GFAPGFP)14Mes/J
002856   FVB/N-Tg(TIE2-lacZ)182Sato/J
002384   FVB/N-Tg(UcpDta)1Kz/J
001800   FVB/NJ
001491   FVB/NMob
000804   HPG/BmJ
000734   MOLD/RkJ
000550   MOLF/EiJ
002423   NON/ShiLtJ
000679   P/J
000680   PL/J
000268   RSV/LeJ
000269   SB/LeJ
010968   SB;C3Sn-Lrp4mdig-2J/GrsrJ
005651   SJL.AK-Thy1a/TseJ
000686   SJL/J
000688   ST/bJ
004808   STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
002648   STOCK a/a Cln6nclf/J
000279   STOCK gr +/+ Ap3d1mh/J
005965   STOCK Tg(Pomc1-cre)16Lowl/J
004770   SW.B6-Soab/J
002023   SWR.M-Emv21 Emv22/J
000689   SWR/J
000939   SWR/J-Clcn1adr-mto/J
100410   WBB6F1/J-KitW/KitW-v/J
000693   WC/ReJ KitlSl/J
View Strains carrying   Pde6brd1     (73 strains)

View Strains carrying other alleles of Kit     (38 strains)

View Strains carrying other alleles of Pde6b     (13 strains)

Additional Web Information

JAX® NOTES, April 1988; 433. H-2 Haplotypes of Mice from Jackson Laboratory Production Colonies.
JAX® NOTES, Spring 2002; 485. Genetic Background Effects: Can Your Mice See?

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Gastrointestinal Stromal Tumor; GIST   (KIT)
Mast Cell Disease   (KIT)
Night Blindness, Congenital Stationary, Autosomal Dominant 2; CSNBAD2   (PDE6B)
Piebald Trait; PBT   (KIT)
Retinitis Pigmentosa 40; RP40   (PDE6B)
Testicular Germ Cell Tumor; TGCT   (KIT)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

KitW/Kit+

        Background Not Specified
  • pigmentation phenotype
  • abnormal coat/hair pigmentation   (MGI Ref ID J:12955)
    • irregular coat pigmentation
      • pigmented areas of the coat may be interspersed with white hairs producing a roan appearance pigmented coat may be interspersed with white hairs creating a roan appearance pigmented areas are interspersed with white hairs producing a roan appearance   (MGI Ref ID J:12955)
    • variable body spotting
      • variable amounts of white spotting   (MGI Ref ID J:12955)
  • hematopoietic system phenotype
  • *normal* hematopoietic system phenotype
    • blood parameters are normal   (MGI Ref ID J:14978)
  • reproductive system phenotype
  • *normal* reproductive system phenotype
    • system is normal   (MGI Ref ID J:14978)
  • integument phenotype
  • abnormal coat/hair pigmentation   (MGI Ref ID J:12955)
    • irregular coat pigmentation
      • pigmented areas of the coat may be interspersed with white hairs producing a roan appearance pigmented coat may be interspersed with white hairs creating a roan appearance pigmented areas are interspersed with white hairs producing a roan appearance   (MGI Ref ID J:12955)
    • variable body spotting
      • variable amounts of white spotting   (MGI Ref ID J:12955)

KitW/KitW

        Background Not Specified
  • mortality/aging
  • complete postnatal lethality
    • death is within the first week of birth   (MGI Ref ID J:12955)
  • hematopoietic system phenotype
  • macrocytic anemia
    • macrocytic anemia begins at 12 days gestation leading to death within the first week of birth   (MGI Ref ID J:14978)
  • pigmentation phenotype
  • abnormal eye pigmentation
    • pigment is restricted to retina   (MGI Ref ID J:12955)
  • absent coat pigmentation
    • white coat color, vividly contrasts with normal black eye color   (MGI Ref ID J:12955)
  • vision/eye phenotype
  • abnormal eye pigmentation
    • pigment is restricted to retina   (MGI Ref ID J:12955)
  • integument phenotype
  • absent coat pigmentation
    • white coat color, vividly contrasts with normal black eye color   (MGI Ref ID J:12955)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Sensorineural Research
Retinal Degeneration
      Pde6brd1

KitW related

Cancer Research
Growth Factors/Receptors/Cytokines
Increased Tumor Incidence
      Gonadal Tumors
      Gonadal Tumors: ovarian
Oncogenes

Dermatology Research
Color and White Spotting Defects

Developmental Biology Research
Neural Crest Defects

Endocrine Deficiency Research
Bone/Bone Marrow Defects
Gonad Defects
Skin Defects

Immunology, Inflammation and Autoimmunity Research
Immunodeficiency
      Mast Cell Deficiency

Neurobiology Research
Hearing Defects
Receptor Defects

Reproductive Biology Research
Developmental Defects Affecting Gonads
      germ cell deficient
Fertility Defects
Gonadal Tumors
      ovarian

Research Tools
Immunology, Inflammation and Autoimmunity Research
      Mast Cell Deficiency

Sensorineural Research
Hearing Defects
Retinal Degeneration

Pde6brd1 related

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol KitW
Allele Name dominant spotting
Allele Type Spontaneous
Common Name(s) W;
Strain of Originold mutant of the mouse fancy
Gene Symbol and Name Kit, kit oncogene
Chromosome 5
Gene Common Name(s) Bs; C-Kit; CD117; Dominant white spotting; Fdc; Gsfsco1; Gsfsco5; Gsfsow3; PBT; SCFR; SCO1; SCO5; SOW3; Ssm; Steel Factor Receptor; Tr-kit; W; belly-spot; dominant spotting; gsf spotted coat 1; gsf spotted coat 5; phenotype like Sl or W 3; spotted sterile male;
General Note This is an old mutant of the mouse fancy. KitW mutants are a potential model for human inherited pure red cell anemia, called Diamond-Blackfan anemia (OMIM 205900), but mouse mutants do not respond to corticosteroid treatment as do human patients. Thus, the mechanism of anemia causation in the two conditions must be different (J:14286).
Molecular Note A guanosine to adenosine substitution at the first nucleotide at the 5' boundary of the intron following the transmembrane exon results in two different aberrantly spliced transcripts putatively expressed in a tissue specific manner. A deletion of 107 bp was found in transcripts from mast cells of mutant mice. A deletion of 234 was found in transcripts from brain or bone marrow cells. The GT to AT point mutation probably disrupted a splice donor site, thereby causing exon skipping. The 107 bp deletion could have resulted from skipping of a transmembrane region exon and the 234 bp deletion from skipping 3 exons. The 107 bp deletion would generate a stop codon 12 bp downstream because of a frame shift, whereas the larger deletion would still be in frame. Northern blot analysis indicated that mast cells from mutants have only 31-37% of the transcripts as mast cells derived from normal bone marrow, suggesting that the mutation may reduce efficiency and authenticity of transcription and splicing. [MGI Ref ID J:91867]
 
Allele Symbol Pde6brd1
Allele Name retinal degeneration 1
Allele Type Spontaneous
Common Name(s) Pdebrd1; rd; rd-1; rd1; rodless retina;
Strain of Originvarious
Gene Symbol and Name Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
Chromosome 5
Gene Common Name(s) CSNB3; CSNBAD2; PDEB; Pdeb; RP40; nmf137; phosphodiesterase, cGMP, rod receptor, beta polypeptide; r; rd; rd-1; rd1; rd10; retinal degeneration; retinal degeneration 1; retinal degeneration 10;
General Note The following inbred strains are known to be homozygous for Pde6b: C3H sublines, CBA/J, FVB/NJ, PL/J, SB, SJL/J, and SWR/J.
Molecular Note Two mutations have been identified in rd1 mice. A murine leukimia virus (Xmv-28) insertion in reverse orientation in intron 1 is found in all mouse strains with the rd1 phenotype. Further, a nonsense mutation (C to A transversion) in codon 347 that results in a truncation eliminating more than half of the predicted encoded protein, including the catalytic domain has also been identified in all rd1 strains of mice. A specific degradation of mutant transcript during or after pre-mRNA splicing is suggested. [MGI Ref ID J:11513] [MGI Ref ID J:4366] [MGI Ref ID J:51361]

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Arguello F; Furlanetto RW; Baggs RB; Graves BT; Harwell SE; Cohen HJ; Frantz CN. 1992. Incidence and distribution of experimental metastases in mutant mice with defective organ microenvironments (genotypes Sl/Sld and W/Wv). Cancer Res 52(8):2304-9. [PubMed: 1559233]  [MGI Ref ID J:468]

Murphy ED. 1972. Hyperplastic and early neoplastic changes in the ovaries of mice after genic deletion of germ cells. J Natl Cancer Inst 48(5):1283-95. [PubMed: 4337905]  [MGI Ref ID J:5274]

Nocka K; Tan JC; Chiu E; Chu TY; Ray P; Traktman P; Besmer P. 1990. Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W. EMBO J 9(6):1805-13. [PubMed: 1693331]  [MGI Ref ID J:10528]

Reis MM; Tsai MC; Schlegel PN; Feliciano M; Raffaelli R; Rosenwaks Z; Palermo GD. 2000. Xenogeneic transplantation of human spermatogonia. Zygote 8(2):97-105. [PubMed: 10857580]  [MGI Ref ID J:109890]

Russell ES; Lawson FA. 1959. Selection and inbreeding for longevity of a lethal type J Hered 50:19-25.  [MGI Ref ID J:2469]

Shyu H; Hsu S; Hsieh-Li H; Li H. 2001. A novel member of the RBCC family, Trif, expressed specifically in the spermatids of mouse testis. Mech Dev 108(1-2):213-6. [PubMed: 11578878]  [MGI Ref ID J:71914]

Additional References

Chang B; Hawes NL; Hurd RE; Davisson MT; Nusinowitz S; Heckenlively JR. 2002. Retinal degeneration mutants in the mouse. Vision Res 42(4):517-25. [PubMed: 11853768]  [MGI Ref ID J:75095]

Kitamura Y; Kasugai T; Ebi Y; Nomura S. 1991. Fibroblast-dependent differentiation/proliferation of mast cells. Skin Pharmacol 4 Suppl 1:2-7. [PubMed: 1764248]  [MGI Ref ID J:619]

Lai YL; Li H; Chiang HS; Hsieh-Li HM. 2002. Expression of a novel TGIF subclass homeobox gene, Tex1, in the spermatids of mouse testis during spermatogenesis. Mech Dev 113(2):185-7. [PubMed: 11960710]  [MGI Ref ID J:76545]

Ross AJ; Amy SP; Mahar PL; Lindsten T; Knudson CM; Thompson CB; Korsmeyer SJ; MacGregor GR. 2001. BCLW Mediates Survival of Postmitotic Sertoli Cells by Regulating BAX Activity. Dev Biol 239(2):295-308. [PubMed: 11784036]  [MGI Ref ID J:72582]

KitW related

Agosti V; Corbacioglu S; Ehlers I; Waskow C; Sommer G; Berrozpe G; Kissel H; Tucker CM; Manova K; Moore MA; Rodewald HR; Besmer P. 2004. Critical Role for Kit-mediated Src Kinase But Not PI 3-Kinase Signaling in Pro T and Pro B Cell Development. J Exp Med 199(6):867-78. [PubMed: 15024050]  [MGI Ref ID J:90485]

Akahoshi M; Song CH; Piliponsky AM; Metz M; Guzzetta A; Abrink M; Schlenner SM; Feyerabend TB; Rodewald HR; Pejler G; Tsai M; Galli SJ. 2011. Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice. J Clin Invest 121(10):4180-91. [PubMed: 21926462]  [MGI Ref ID J:178494]

Andoh T; Sakai K; Urashima M; Kitazawa K; Honma A; Kuraishi Y. 2012. Involvement of leukotriene B4 in itching in a mouse model of ocular allergy. Exp Eye Res 98:97-103. [PubMed: 22504036]  [MGI Ref ID J:196831]

Aoki H; Hara A; Motohashi T; Kunisada T. 2011. Protective effect of Kit signaling for melanocyte stem cells against radiation-induced genotoxic stress. J Invest Dermatol 131(9):1906-15. [PubMed: 21633369]  [MGI Ref ID J:182201]

Aoki H; Yamada Y; Hara A; Kunisada T. 2009. Two distinct types of mouse melanocyte: differential signaling requirement for the maintenance of non-cutaneous and dermal versus epidermal melanocytes. Development 136(15):2511-21. [PubMed: 19553284]  [MGI Ref ID J:152856]

Aoki R; Kawamura T; Goshima F; Ogawa Y; Nakae S; Nakao A; Moriishi K; Nishiyama Y; Shimada S. 2013. Mast Cells Play a Key Role in Host Defense against Herpes Simplex Virus Infection through TNF-alpha and IL-6 Production. J Invest Dermatol 133(9):2170-9. [PubMed: 23528820]  [MGI Ref ID J:200049]

Arinobu Y; Iwasaki H; Gurish MF; Mizuno S; Shigematsu H; Ozawa H; Tenen DG; Austen KF; Akashi K. 2005. Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis. Proc Natl Acad Sci U S A 102(50):18105-10. [PubMed: 16330751]  [MGI Ref ID J:104357]

Arnold K; Sarkar A; Yram MA; Polo JM; Bronson R; Sengupta S; Seandel M; Geijsen N; Hochedlinger K. 2011. Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice. Cell Stem Cell 9(4):317-29. [PubMed: 21982232]  [MGI Ref ID J:177655]

Ayach BB; Yoshimitsu M; Dawood F; Sun M; Arab S; Chen M; Higuchi K; Siatskas C; Lee P; Lim H; Zhang J; Cukerman E; Stanford WL; Medin JA; Liu PP. 2006. Stem cell factor receptor induces progenitor and natural killer cell-mediated cardiac survival and repair after myocardial infarction. Proc Natl Acad Sci U S A 103(7):2304-9. [PubMed: 16467148]  [MGI Ref ID J:106065]

Azuma T; Dojyo M; Ito S; Yamazaki Y; Miyaji H; Ito Y; Suto H; Kuriyama M; Kato T; Kohli Y. 1999. Bile reflux due to disturbed gastric movement is a cause of spontaneous gastric ulcer in W/Wv mice. Dig Dis Sci 44(6):1177-83. [PubMed: 10389693]  [MGI Ref ID J:57206]

Baumann U; Chouchakova N; Gewecke B; Kohl J; Carroll MC; Schmidt RE; Gessner JE. 2001. Distinct tissue site-specific requirements of mast cells and complement components C3/C5a receptor in IgG immune complex-induced injury of skin and lung. J Immunol 167(2):1022-7. [PubMed: 11441111]  [MGI Ref ID J:120524]

Beckett EA; Ro S; Bayguinov Y; Sanders KM; Ward SM. 2007. Kit signaling is essential for development and maintenance of interstitial cells of Cajal and electrical rhythmicity in the embryonic gastrointestinal tract. Dev Dyn 236(1):60-72. [PubMed: 16937373]  [MGI Ref ID J:116633]

Bennett JL; Blanchet MR; Zhao L; Zbytnuik L; Antignano F; Gold M; Kubes P; McNagny KM. 2009. Bone marrow-derived mast cells accumulate in the central nervous system during inflammation but are dispensable for experimental autoimmune encephalomyelitis pathogenesis. J Immunol 182(9):5507-14. [PubMed: 19380799]  [MGI Ref ID J:147712]

Bernstein SE. 1969. Hereditary disorders of the rodent erythron. In: Genetics in Laboratory Animal Medicine. Natl Acad Sci Publ, Washington, DC.  [MGI Ref ID J:30699]

Bhetwal BP; Sanders KM; An C; Trappanese DM; Moreland RS; Perrino BA. 2013. Ca2+ sensitization pathways accessed by cholinergic neurotransmission in the murine gastric fundus. J Physiol 591(Pt 12):2971-86. [PubMed: 23613531]  [MGI Ref ID J:210571]

Biedermann T; Kneilling M; Mailhammer R; Maier K; Sander CA; Kollias G; Kunkel SL; Hultner L; Rocken M. 2000. Mast cells control neutrophil recruitment during T cell-mediated delayed-type hypersensitivity reactions through tumor necrosis factor and macrophage inflammatory protein 2 J Exp Med 192(10):1441-52. [PubMed: 11085746]  [MGI Ref ID J:65843]

Blanchet MR; Gold M; Maltby S; Bennett J; Petri B; Kubes P; Lee DM; McNagny KM. 2010. Loss of CD34 leads to exacerbated autoimmune arthritis through increased vascular permeability. J Immunol 184(3):1292-9. [PubMed: 20038636]  [MGI Ref ID J:159534]

Bosch-Marce M; Okuyama H; Wesley JB; Sarkar K; Kimura H; Liu YV; Zhang H; Strazza M; Rey S; Savino L; Zhou YF; McDonald KR; Na Y; Vandiver S; Rabi A; Shaked Y; Kerbel R; Lavallee T; Semenza GL. 2007. Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia. Circ Res 101(12):1310-8. [PubMed: 17932327]  [MGI Ref ID J:142789]

Burke JM; Ganley-Leal LM; Khatri A; Wetzler LM. 2007. Neisseria meningitidis PorB, a TLR2 ligand, induces an antigen-specific eosinophil recall response: potential adjuvant for helminth vaccines? J Immunol 179(5):3222-30. [PubMed: 17709538]  [MGI Ref ID J:151825]

Campagnolo L; Moscatelli I; Pellegrini M; Siracusa G; Stuhlmann H. 2008. Expression of EGFL7 in primordial germ cells and in adult ovaries and testes. Gene Expr Patterns 8(6):389-96. [PubMed: 18556249]  [MGI Ref ID J:137617]

Cara DC; Ebbert KV; McCafferty DM. 2004. Mast cell-independent mechanisms of immediate hypersensitivity: a role for platelets. J Immunol 172(8):4964-71. [PubMed: 15067077]  [MGI Ref ID J:89115]

Chakraborty P; William Buaas F; Sharma M; Smith BE; Greenlee AR; Eacker SM; Braun RE. 2014. Androgen-dependent sertoli cell tight junction remodeling is mediated by multiple tight junction components. Mol Endocrinol 28(7):1055-72. [PubMed: 24825397]  [MGI Ref ID J:210656]

Chappaz S; Gartner C; Rodewald HR; Finke D. 2010. Kit ligand and Il7 differentially regulate Peyer's patch and lymph node development. J Immunol 185(6):3514-9. [PubMed: 20709954]  [MGI Ref ID J:163826]

Chen L; Faire M; Kissner MD; Laird DJ. 2013. Primordial germ cells and gastrointestinal stromal tumors respond distinctly to a cKit overactivating allele. Hum Mol Genet 22(2):313-27. [PubMed: 23077213]  [MGI Ref ID J:191131]

Chen R; Ning G; Zhao ML; Fleming MG; Diaz LA; Werb Z; Liu Z. 2001. Mast cells play a key role in neutrophil recruitment in experimental bullous pemphigoid. J Clin Invest 108(8):1151-8. [PubMed: 11602622]  [MGI Ref ID J:72195]

Chen X; Feng BS; Zheng PY; Liao XQ; Chong J; Tang SG; Yang PC. 2008. Fc gamma receptor signaling in mast cells links microbial stimulation to mucosal immune inflammation in the intestine. Am J Pathol 173(6):1647-56. [PubMed: 18974296]  [MGI Ref ID J:143927]

Cheng M; Zhou J; Wu M; Boriboun C; Thorne T; Liu T; Xiang Z; Zeng Q; Tanaka T; Tang YL; Kishore R; Tomasson MH; Miller RJ; Losordo DW; Qin G. 2010. CXCR4-mediated bone marrow progenitor cell maintenance and mobilization are modulated by c-kit activity. Circ Res 107(9):1083-93. [PubMed: 20847314]  [MGI Ref ID J:178186]

Chikahisa S; Kodama T; Soya A; Sagawa Y; Ishimaru Y; Sei H; Nishino S. 2013. Histamine from brain resident MAST cells promotes wakefulness and modulates behavioral states. PLoS One 8(10):e78434. [PubMed: 24205232]  [MGI Ref ID J:209229]

Choi E; Han C; Park I; Lee B; Jin S; Choi H; Kim do H; Park ZY; Eddy EM; Cho C. 2008. A novel germ cell-specific protein, SHIP1, forms a complex with chromatin remodeling activity during spermatogenesis. J Biol Chem 283(50):35283-94. [PubMed: 18849567]  [MGI Ref ID J:144592]

Choi IH; Shin YM; Park JS; Lee MS; Han EH; Chai OH; Im SY; Ha TY; Lee HK. 1998. Immunoglobulin E-dependent active fatal anaphylaxis in mast cell-deficient mice. J Exp Med 188(9):1587-92. [PubMed: 9802970]  [MGI Ref ID J:50773]

Cimini M; Fazel S; Zhuo S; Xaymardan M; Fujii H; Weisel RD; Li RK. 2007. c-kit dysfunction impairs myocardial healing after infarction. Circulation 116(11 Suppl):I77-82. [PubMed: 17846329]  [MGI Ref ID J:139839]

Clark EA; Shultz LD; Pollack SB. 1981. Mutations in mice that influence natural killer (NK) cell activity. Immunogenetics 12(5-6):601-13. [PubMed: 6971254]  [MGI Ref ID J:6485]

Cohn L; Homer RJ; MacLeod H; Mohrs M; Brombacher F; Bottomly K. 1999. Th2-induced airway mucus production is dependent on IL-4Ralpha, but not on eosinophils. J Immunol 162(10):6178-83. [PubMed: 10229862]  [MGI Ref ID J:119786]

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Popper P; Farber DB; Micevych PE; Minoofar K; Bronstein JM. 1997. TRPM-2 expression and tunel staining in neurodegenerative diseases: studies in wobbler and rd mice. Exp Neurol 143(2):246-54. [PubMed: 9056387]  [MGI Ref ID J:38831]

Portera-Cailliau C; Sung CH; Nathans J; Adler R. 1994. Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa. Proc Natl Acad Sci U S A 91(3):974-8. [PubMed: 8302876]  [MGI Ref ID J:16708]

Provencio I; Cooper HM; Foster RG. 1998. Retinal projections in mice with inherited retinal degeneration: implications for circadian photoentrainment. J Comp Neurol 395(4):417-39. [PubMed: 9619497]  [MGI Ref ID J:47756]

Provencio I; Foster RG. 1995. Circadian rhythms in mice can be regulated by photoreceptors with cone-like characteristics. Brain Res 694(1-2):183-90. [PubMed: 8974643]  [MGI Ref ID J:29236]

Provencio I; Wong S; Lederman AB; Argamaso SM; Foster RG. 1994. Visual and circadian responses to light in aged retinally degenerate mice. Vision Res 34(14):1799-806. [PubMed: 7941382]  [MGI Ref ID J:19843]

Punzo C; Cepko C. 2007. Cellular responses to photoreceptor death in the rd1 mouse model of retinal degeneration. Invest Ophthalmol Vis Sci 48(2):849-57. [PubMed: 17251487]  [MGI Ref ID J:123282]

Punzo C; Kornacker K; Cepko CL. 2009. Stimulation of the insulin/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa. Nat Neurosci 12(1):44-52. [PubMed: 19060896]  [MGI Ref ID J:144720]

Qiao X; Pennesi M; Seong E; Gao H; Burmeister M; Wu SM. 2003. Photoreceptor degeneration and rd1 mutation in the grizzled/mocha mouse strain. Vision Res 43(8):859-65. [PubMed: 12668055]  [MGI Ref ID J:88031]

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Rao A; Dallman R; Henderson S; Chen CK. 2007. Gbeta5 is required for normal light responses and morphology of retinal ON-bipolar cells. J Neurosci 27(51):14199-204. [PubMed: 18094259]  [MGI Ref ID J:129267]

Read DS; McCall MA; Gregg RG. 2002. Absence of voltage-dependent calcium channels delays photoreceptor degeneration in rd mice. Exp Eye Res 75(4):415-20. [PubMed: 12387789]  [MGI Ref ID J:79923]

Rich KA; Zhan Y; Blanks JC. 1997. Migration and synaptogenesis of cone photoreceptors in the developing mouse retina. J Comp Neurol 388(1):47-63. [PubMed: 9364238]  [MGI Ref ID J:44100]

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Rohrer B; Demos C; Frigg R; Grimm C. 2007. Classical complement activation and acquired immune response pathways are not essential for retinal degeneration in the rd1 mouse. Exp Eye Res 84(1):82-91. [PubMed: 17069800]  [MGI Ref ID J:123183]

Rossi C; Strettoi E; Galli-Resta L. 2003. The spatial order of horizontal cells is not affected by massive alterations in the organization of other retinal cells. J Neurosci 23(30):9924-8. [PubMed: 14586022]  [MGI Ref ID J:120041]

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Ryu SB; Ye JH; Goo YS; Kim CH; Kim KH. 2010. Temporal response properties of retinal ganglion cells in rd1 mice evoked by amplitude-modulated electrical pulse trains. Invest Ophthalmol Vis Sci 51(12):6762-9. [PubMed: 20671284]  [MGI Ref ID J:171389]

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Sasahara M; Otani A; Oishi A; Kojima H; Yodoi Y; Kameda T; Nakamura H; Yoshimura N. 2008. Activation of bone marrow-derived microglia promotes photoreceptor survival in inherited retinal degeneration. Am J Pathol 172(6):1693-703. [PubMed: 18483210]  [MGI Ref ID J:136339]

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Selby CP; Thompson C; Schmitz TM; Van Gelder RN; Sancar A. 2000. Functional redundancy of cryptochromes and classical photoreceptors for nonvisual ocular photoreception in mice Proc Natl Acad Sci U S A 97(26):14697-702. [PubMed: 11114194]  [MGI Ref ID J:66580]

Semo M; Gias C; Ahmado A; Sugano E; Allen AE; Lawrence JM; Tomita H; Coffey PJ; Vugler AA. 2010. Dissecting a role for melanopsin in behavioural light aversion reveals a response independent of conventional photoreception. PLoS One 5(11):e15009. [PubMed: 21124784]  [MGI Ref ID J:167120]

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Thompson CL; Selby CP; Partch CL; Plante DT; Thresher RJ; Araujo F; Sancar A. 2004. Further evidence for the role of cryptochromes in retinohypothalamic photoreception/phototransduction. Brain Res Mol Brain Res 122(2):158-66. [PubMed: 15010208]  [MGI Ref ID J:88468]

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Thompson S; Mullins RF; Philp AR; Stone EM; Mrosovsky N. 2008. Divergent phenotypes of vision and accessory visual function in mice with visual cycle dysfunction (Rpe65 rd12) or retinal degeneration (rd/rd). Invest Ophthalmol Vis Sci 49(6):2737-42. [PubMed: 18515598]  [MGI Ref ID J:137044]

Thompson S; Stasheff SF; Hernandez J; Nylen E; East JS; Kardon RH; Pinto LH; Mullins RF; Stone EM. 2011. Different inner retinal pathways mediate rod-cone input in irradiance detection for the pupillary light reflex and regulation of behavioral state in mice. Invest Ophthalmol Vis Sci 52(1):618-23. [PubMed: 20847113]  [MGI Ref ID J:171559]

Thyagarajan S; van Wyk M; Lehmann K; Lowel S; Feng G; Wassle H. 2010. Visual function in mice with photoreceptor degeneration and transgenic expression of channelrhodopsin 2 in ganglion cells. J Neurosci 30(26):8745-58. [PubMed: 20592196]  [MGI Ref ID J:161847]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX5

Colony Maintenance

Breeding & HusbandryWildtype mice from this colony frequently show small belly spots on an otherwise non-diluted black background. Attempts to breed away from this phenotype can reduce the incidence, but can not fully eliminate it.
Mating SystemHeterozygote x +/+ sibling         (Female x Male)   27-NOV-07
+/+ sibling x Heterozygote         (Female x Male)   27-NOV-07
Breeding Considerations This strain is a good breeder.
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Weeks of AgePrice per mouse (US dollars $)GenderGenotypes Provided
3 weeks $293.40Female or MaleHeterozygous for KitW  
4 weeks $293.40Female or MaleHeterozygous for KitW  
5 weeks $293.40Female or MaleHeterozygous for KitW  
6 weeks $296.85Female or MaleHeterozygous for KitW  
7 weeks $300.30Female or MaleHeterozygous for KitW  
8 weeks $303.75Female or MaleHeterozygous for KitW  
Price per Pair (US dollars $)Pair Genotype
$368.85Heterozygous for KitW x Wild-type for KitW  

Standard Supply

Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.

Supply Notes

  • Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Weeks of AgePrice per mouse (US dollars $)GenderGenotypes Provided
3 weeks $381.50Female or MaleHeterozygous for KitW  
4 weeks $381.50Female or MaleHeterozygous for KitW  
5 weeks $381.50Female or MaleHeterozygous for KitW  
6 weeks $386.00Female or MaleHeterozygous for KitW  
7 weeks $390.40Female or MaleHeterozygous for KitW  
8 weeks $394.90Female or MaleHeterozygous for KitW  
Price per Pair (US dollars $)Pair Genotype
$479.60Heterozygous for KitW x Wild-type for KitW  

Standard Supply

Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.

Supply Notes

  • Shipped at a specific age in weeks. Mice at a precise age in days, littermates and retired breeders are also available.
View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months.

Control Information

  Control
   Wild-type from the colony
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Important Note

This strain is homozygous for the retinal degeneration allele Pde6brd1. See article "Genetic Background Effects: Can Your Mice See?", JAX® NOTES Spring 2002, No. 485.

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

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In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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