Strain Name: |
129P3/J-Leprdb-3J/J |
|---|---|
Stock Number: |
000709 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Genes & Alleles | Lepr; Leprdb-3J; |
Type JAX® GEMM® Strain - Mutant Strain Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Spontaneous Mutation Species laboratory mouse Generation N7F13N1 Strain Description
Mice homozygous for the diabetes 3J spontaneous mutation (Leprdb-3J) become identifiably obese around 3 to 4 weeks of age. Elevations of plasma insulin begin at 10 to 14 days and of blood sugar at 4 to 8 weeks. Homozygous mutant mice are polyphagic, polydipsic, and polyuric. The course of the disease is markedly influenced by genetic background. Homozygous mutant mice on the 129P3/J background exhibit severe obesity but the diabetes phenotype is much reduced.
Mammalian Phenotype Terms assigned by genotype |
| Allele Symbol | Leprdb-3J | ||
|---|---|---|---|
| Allele Name | diabetes 3 Jackson | ||
| Strain of Origin | 129P3/J | ||
| Gene Symbol and Name | Lepr, leptin receptor | ||
| Chromosome | 4 | ||
| Gene Common Name(s) | CD295; Fa; LEPROT; Leprb; Modb1; OB-RGRP; OBR; db; diabetes; leptin receptor gene-related protein; obese-like; obl; | ||
| Molecular Note | Sequence analysis of the 3J allele revealed a 17 nucleotide deletion beginning at base 1874. This deletion results in a shift of the reading frame, and a premature termination of the protein at the 11th amino acid after the deletion site. The mutation is predicted to result in a truncated receptor without a transmembrane domain and affects all Lepr splice variants. [MGI Ref ID J:40658] | ||
| Control | ||
|---|---|---|
| Untyped from the colony | ||
| 000690 129P3/J | ||
| Considerations for Choosing Controls | ||
Strains carrying other alleles of Lepr
002048 B6 x C57BLKS-m Leprdb Myo15sh2-J/J 000697 B6.Cg-m +/+ Leprdb/J 000699 B6.Cg-m Leprdb/+ +/J 000642 BKS.Cg-m +/+ Leprdb/J 000700 BKS.Cg-m Leprdb/+ +/J 001192 BKS.Cg-meaJ Leprdb +/+ + m/J 000707 CBA.Cg-m Leprdb/+ +/J 006654 FVB.BKS(D)-Leprdb/ChuaJ 004939 NOD/ShiLtJ-Leprdb-5J/LtJ 006846 STOCK Leprdb-9J/Jgn View Strains carrying other alleles of Lepr (10 strains)
New 129 Nomenclature Bulletin
Leprdb-3J related
Diabetes and Obesity Research
Hyperglycemia
Hyperinsulinemia
Insulin Resistance
Obesity With Diabetes
Type 2 Diabetes (NIDDM)
Endocrine Deficiency Research
Adipose Defects
Hypothalamus/Pituitary Defects
Pancreas Defects
Immunology and Inflammation Research
Immunodeficiency Associated with Other Defects
Internal/Organ Research
Adipose Defects
Metabolism Research
Mouse/Human Gene Homologs
obesity, morbid, with hypogonadism (rare)
Reproductive Biology Research
Fertility Defects
| Strain Name: | 129P3/J-Leprdb-3J/J |
| Stock Number: | 000709 |
IMPORTANT NOTE: Prices are based on shipping destination. To view prices, select your shipping destination.
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery of Strains Needing Progeny Testing. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two untested males and two untested females (two pairs) will be recovered, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the overall recovery time to approximately 25 weeks. However, all pups recovered will be sent. Progeny testing is required to identify the genotype of mice of this strain, as a genotyping assay is not available. This type of testing involves breeding the recovered animals and assessing the phenotype of the offspring in order to identify animals carrying the mutation of interest. We can perform the progeny testing for you as a service or we can ship all recovered animals (at least two untested pairs) to you for progeny testing at your facility. If you perform the progeny testing, there is NO guarantee that a carrier will be identified. If we perform progeny testing as a service, additional breeding time will be required. In this case, when a male and female (one pair) are identified that carry the mutation, they and their offspring will be shipped. Delivery time for strains requiring progeny testing often exceeds 25 weeks and may take 12 months or more due to the difficulties in breeding some strains. The progeny testing cost is in addition to the recovery cost and is based on the number of boxes used and the time taken to produce the mice identified as carrying the mutation. Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Please contact Customer Service for more information on the cost of progeny testing for a strain: Tel: 1-800-422-6423 or 1-207-288-5845. Cryorecovery to establish a Dedicated Supply for greater quantities of mice |
| Licensing | See General Terms and Conditions below |
| Control Information | View Control Information in Strain Details. |
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