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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Type Chromosome Aberration; Robertsonian; Translocation; Additional information on Mice with Chromosomal Aberrations. Type Inbred Strain; Additional information on Inbred Strains. Mating System Sibling x Sibling (Female x Male) Species Wild and outbred Swiss and M. m. domesticus Appearance
albino, retinal degeneration
Related Genotype: Tyrc/Tyrc Mc1rE-tob/Mc1rE-tobImportant Note
This strain is homozygous for retinal degeneration 3, rd3.Description
The RBF inbred strain arose from crosses with wild mice, originally known as "tobacco mouse", captured in Valle di Poschiavo in S.E. Switzerland. The wild mice originally known as 'tobacco mouse' because of the coat colour. The strain was transferred to Dr. M. Davisson (Dn) in 1981 and subsequently to the production colony of The Jackson Laborotory (J). Mice are homozygous for Robertsonian translocation Rb(1.3)1Bnr, Rb(8.12)5Bnr and Rb(9.14)6Bnr. This strain is useful for production of antibody producing hybridomas.Development
RBF stands for Robertsonian (RB) POSF. POSF was a subline of M. m. domesticus poschiavinus wild derived stock, which had several Robertsonian translocations. Alfred Gropp mated feral male from the Seiss Poschiavo Valley to a Swiss strain and F1 hybrids were received by Tom Roderick at The Jackson Laboratory where the colony was subsequently transferred to Davisson. In September 1983 this strain reached generation F53.
Related Strains
Combined Robertsonian Chromosome Stocks
002040 RB126Bnr/EiJ 002041 RB16Bnr/EiJ 001000 RBD/DnJ 000807 RBJ/DnJ 000896 STOCK Rb(2.18)6Rma Rb(12.14)8Rma/J 000864 STOCK Rb(2.8)2Lub Rb(7.18)9Lub/J 000929 TIRANO/EiJ 001746 WMP/PasDnJ 001392 ZALENDE/EiJ View Combined Robertsonian Chromosome Stocks (9 strains)
000807 RBJ/DnJ 000852 STOCK In(5)30Rk/J 000729 STOCK Rb(11.13)4Bnr/J
Additional Web Information
Genetic Quality Control Annual Report
JAX® NOTES, July 1987; 430. RBF/DnJ, an Inbred Mouse Strain for Hybridoma Production.
JAX® NOTES, July 1988; 434. Robertsonian Chromosome Resource.
Phenotype
Phenotype Information
Mouse Phenome Database
Festing Inbred Strain Characteristics: RBF
This mouse can be used to support research in many areas including:
Rb(1.3)1Bnr relatedNeurobiology Research
Vestibular and Hearing Defects (Age related hearing loss)
Research Tools
Cancer Research (myeloma and hybridoma production)
Genetics Research (Mutagenesis and Transgenesis: multiple Robertsonian chromosomes)
Genetics Research (Tissue/Cell Markers: multiple Robertsonian chromosomes)
Sensorineural Research
Retinal Degeneration (Homozygous for rd3)
Rb(9.14)6Bnr relatedResearch Tools
Genetics Research (Gene Mapping)
Genetics Research (Gene Mapping)Mc1rE-tob related
Endocrine Deficiency Research
Skin Defects
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Mc1rE-tob | ||
|---|---|---|---|
| Allele Name | tobacco darkening | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | Etob; | ||
| Strain of Origin | M. m. domesticus poschiavinus | ||
| Gene Symbol and Name | Mc1r, melanocortin 1 receptor | ||
| Chromosome | 8 | ||
| Gene Common Name(s) | MGC14337; MSH-R; Mshra; SHEP2; Tob; e; extension recessive yellow; extension, recessive yellow; melanocyte hormone receptor alpha; tobacco darkening; | ||
| General Note | Mc1rE-tob, tobacco darkening, semidominant. Formerly Etob. Mice of the species Mus poschiavinus, the tobacco mouse, are homozygous for this allele. They are black in color until the eighth week, after which the flanks become agouti.In descendants from crosses with Mus musculus, Mc1rE-tob/+ heterozygotes show an agouti pattern with darkened back. Mc1rE-tob/Mc1re a/a mice are black (J:22593, J:13641). The Mc1rE-tob allele carries two point mutations that result in a receptor that is overactive, though responsive to hormone regulation, and produces a greater activation of the MC1R effector, G protein-coupled adenylyl cyclase, than does the wild-type allele (J:4636). | ||
| Molecular Note | A C-to-T mutation in codon 69 is predicted to result in a serine to leucine alteration at this position. [MGI Ref ID J:4636] | ||
| Allele Symbol | Rd3rd3 | ||
| Allele Name | retinal degeneration 3 | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | RBF/DnJ | ||
| Gene Symbol and Name | Rd3, retinal degeneration 3 | ||
| Chromosome | 1 | ||
| Gene Common Name(s) | 3322402L07Rik; C1orf36; LCA12; RIKEN cDNA 3322402L07 gene; rd-3; | ||
| General Note | This mutation causes retinal degeneration. In homozygous mutant mice, development proceeds normally through the second postnatal week. Thereafter, photoreceptor and outer nuclear layers begin to degenerate, and by 8 weeks, no photoreceptor cells remain. Changes in electroretinograms parallel the histologic changes. As of 1998 this is the only type of retinal degeneration reported in mice in which the photoreceptors are initially normal (J:4367). | ||
| Molecular Note | A C to T substitution in Rd3 results in a stop codon after residue 106. The truncated protein is initially expressed in in vitro assays but is degraded. [MGI Ref ID J:122439] | ||
| Gene Symbol and Name | Rb(9.14)6Bnr, Robertsonian translocation, Chr 9 and 14, Universitat Bonn/Rhein 6 | ||
| Chromosome | 14 | ||
| Gene Common Name(s) | Rb6Bnr; | ||
| Gene Symbol and Name | Rb(1.3)1Bnr, Robertsonian translocation, Chr 1 and 3, Universitat Bonn/Rhein 1 | ||
| Chromosome | 1 | ||
| Gene Common Name(s) | Rb1Bnr; | ||
| Gene Symbol and Name | Rb(8.12)5Bnr, Robertsonian translocation, Chr 8 and 12, Universitat Bonn/Rhein 5 | ||
| Chromosome | 12 | ||
| Gene Common Name(s) | Rb5Bnr; | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Optimizing PCR Protocols
References
References
Additional References
Taggart RT; Samloff IM. 1983. Stable antibody-producing murine hybridomas. Science 219(4589):1228-30. [PubMed: 6402815] [MGI Ref ID J:135139]
Mc1rE-tob relatedRd3rd3 relatedRobbins LS; Nadeau JH; Johnson KR; Kelly MA; Roselli-Rehfuss L; Baack E; Mountjoy KG; Cone RD. 1993. Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function. Cell 72(6):827-34. [PubMed: 8458079] [MGI Ref ID J:4636]
Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York. [MGI Ref ID J:78801]
von Lehmann E. 1973. Coat colour genetics of the tobacco-mouse (Mus poschiavinus Fatio) Mouse News Lett 48:23. [MGI Ref ID J:22593]
von Lehmann E. 1974. Weitere Mitteilungen zu: coat colour genetics of the tobacco-mouse (Mus poschiavinus Fatio). Mouse News Lett 50:26-7. [MGI Ref ID J:13641]
Chang B; Hawes NL; Hurd RE; Davisson MT; Nusinowitz S; Heckenlively JR. 2002. Retinal degeneration mutants in the mouse. Vision Res 42(4):517-25. [PubMed: 11853768] [MGI Ref ID J:75095]
Chang B; Heckenlively JR; Hawes NL; Roderick TH. 1993. New mouse primary retinal degeneration (rd-3). Genomics 16(1):45-9. [PubMed: 8486383] [MGI Ref ID J:4367]
Danciger M; Ogando D; Yang H; Matthes MT; Yu N; Ahern K; Yasumura D; Williams RW; Lavail MM. 2008. Genetic modifiers of retinal degeneration in the rd3 mouse. Invest Ophthalmol Vis Sci 49(7):2863-9. [PubMed: 18344445] [MGI Ref ID J:136923]
Friedman JS; Chang B; Kannabiran C; Chakarova C; Singh HP; Jalali S; Hawes NL; Branham K; Othman M; Filippova E; Thompson DA; Webster AR; Andreasson S; Jacobson SG; Bhattacharya SS; Heckenlively JR; Swaroop A. 2006. Premature truncation of a novel protein, RD3, exhibiting subnuclear localization is associated with retinal degeneration. Am J Hum Genet 79(6):1059-70. [PubMed: 17186464] [MGI Ref ID J:122439]
Hawes NL; Smith RS; Chang B; Davisson M; Heckenlively JR; John SW. 1999. Mouse fundus photography and angiography: a catalogue of normal and mutant phenotypes. Mol Vis 5:22. [PubMed: 10493779] [MGI Ref ID J:59481]
Heckenlively JR; Chang B; Erway LC; Peng C; Hawes NL; Hageman GS; Roderick TH. 1995. Mouse model for Usher syndrome: linkage mapping suggests homology to Usher type I reported at human chromosome 11p15. Proc Natl Acad Sci U S A 92(24):11100-4. [PubMed: 7479945] [MGI Ref ID J:121993]
Pieke-Dahl S; Ohlemiller KK; McGee J; Walsh EJ; Kimberling WJ. 1997. Hearing loss in the RBF/DnJ mouse, a proposed animal model of Usher syndrome type IIa. Hear Res 112(1-2):1-12. [PubMed: 9367224] [MGI Ref ID J:44148]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX29
Colony Maintenance
Mating System Sibling x Sibling (Female x Male)
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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*Price(s) in US dollars ($)
Weeks of Age Price* Gender 3-5 weeks $57.10 Female or Male 6 weeks $59.00 Female or Male 7 weeks $60.90 Female or Male 8 weeks $62.80 Female or Male 9 weeks $64.70 Female or Male 10 weeks $66.60 Female or Male
Additional Supply Details
| Pricing for International shipping destinations |
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*Price(s) in US dollars ($)
Weeks of Age Price* Gender 3-5 weeks $74.30 Female or Male 6 weeks $76.80 Female or Male 7 weeks $79.30 Female or Male 8 weeks $81.80 Female or Male 9 weeks $84.30 Female or Male 10 weeks $86.80 Female or Male
Additional Supply Details
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Supply Details
| Standard Supply | Level 4. Up to 10 mice. Larger quantities or custom orders arranged upon request. Expected delivery up to one to three months. |
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| Supply Notes |
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| Important Note | This strain is homozygous for retinal degeneration 3, rd3. |
General Terms and Conditions
See Terms of Use
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