Strain Name:

STOCK Rb(11.13)4Bnr/J

Stock Number:

000729

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Research Strain

Use Restrictions Apply, see Terms of Use
This inbred strain bears a Robertsonian translocation, Rb(11.13)4Bnr, and a spontaneous eye mutation, Rd3rd3, and was derived from the sibling inbreeding of an F1 cross between a female from the outbred NMRI stock and a wild trapped Mus poschiavinus male from Val Poschiavo, Switzerland. It may be useful for studies of retinal degeneration, cancer, reproduction/meiosis, birth defects, aneuploidy generation, other genomic studies or genetic mapping.

Description

Strain Information

Former Names Rb4Bnr    (Changed: 15-DEC-04 )
Type Chromosome Aberration; Robertsonian;
Additional information on Mice with Chromosomal Aberrations.
Type Mutant Stock;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Specieslaboratory mouse
GenerationF?+17 (27-JUN-14)
Generation Definitions

Appearance
albino
Related Genotype: Tyrc/Tyrc Mc1rE-tob/Mc1rE-tob

Important Note
This strain is homozygous for retinal degeneration 3, rd3.

Description
This inbred strain bears a Robertsonian translocation, Rb(11.13)4Bnr, and a spontaneous eye mutation, Rd3rd3, and was derived from the sibling inbreeding of an F1 cross between a female from the outbred NMRI stock and a wild trapped Mus poschiavinus male from Val Poschiavo, Switzerland. It may be useful for studies of retinal degeneration, cancer, reproduction/meiosis, birth defects, aneuploidy generation, other genomic studies or genetic mapping.

Development
Mus poschiavinus is a species of mouse found in Val Poschiavo, Switzerland. Its genome is organized in a karyotype of 26 chromosomes, instead of the usual 40. This includes 7 pairs of metacentrics, 5 pairs of acrocentrics, and the acrocentric X and Y (Cattanach et al., 1972). Due to the tobacco darkening allele (Mc1rE-tob) in this population, Mus poschiavinus mice have a black coat color that becomes agouti in the flanks after about 8 weeks of age.

In the late 1960s Alfred Gropp bred a Swiss NMRI female to a wild trapped male from Val Poschiavo, Switzerland and sent the F1 offspring to Frank Ruddle at Yale University who shipped these same F1 hybrids to Tom Roderick at The Jackson Laboratory. These F1 hybrids were sibling intercrossed and several inbred lines were generated from inbreeding of this population. These lines were selected for the presence Robertsonian translocations with the intention of generating inbred strains carrying a single Robertsonian or a defined set of Robertsonians. At F3 two lines separated: line PH was inbred to produce a line homozygous for Rb(16.17)7Bnr; and line PI was further separated at generation F4 into lines PAD and PAC. The PAC line was maintained by sibling intercross and the offspring of the F7 sibling intercross were separated into several further sublines, including PJG and PJI, which were each sibling intercrossed for one generation then cousin intercrossed before again being maintained by sibling intercross. In 1977 this line reached generation F17 and was designated subline N and in 1983 it reached generation F32. While this line was selected to be maintained homozygous for Rb(11.13)4Bnr, it had been maintained segregating for Mc1rE-tob and Tyrc, but at some point it became fixed homozygous for Tyrc. In 1990 when this inbred reached generation F73 an attempt was made to cryopreserve embryos but this was not successful. The strain remained on the shelf in the care of Norman Hawes & Bo Chang and they discovered the retinal degeneration 3 mutation (Rd3rd3) in it. Because this strain was inbred from an outbred population crossed to a wild male it has a unique genomic makeup compared with other inbred strains and even with other inbred strains derived from the same ancestral F1 population.

Related Strains

Robertsonian Chromosome
001099   AEJ/GnRk-Rb(11.14)1Dn/J
002545   B6 x RBA/DnJ
000610   B6 x STOCK Rb(6.15)1Ald/J
014109   B6.Cg-Rb(1.2)18Lub/JAmonJ
014110   B6.Cg-Rb(1.3)1EiJ/AmonJ
000861   B6.Cg-Rb(1.3)1Lub/J
000952   B6.Cg-Rb(10.11)8Bnr/J
014115   B6.Cg-Rb(10.12)5Lub/JAmonJ
014117   B6.Cg-Rb(11.13)4Bnr/JAmonJ
014118   B6.Cg-Rb(13.16)1Mpl/JAmonJ
014119   B6.Cg-Rb(16.17)7Bnr/JAmonJ
000960   B6.Cg-Rb(2.8)2Lub/J
014113   B6.Cg-Rb(5.19)1Wh/JAmonJ
014112   B6.Cg-Rb(6.16)24Lub/JAmonJ
014114   B6.Cg-Rb(9.19)163H/JAmonJ
001733   B6.WMP-Rb(10.17)9Mpl/J
014116   B6.WMP-Rb(10.17)9Mpl/JAmonJ
001734   B6.WMP-Rb(13.15)10Mpl/J
001727   B6.WMP-Rb(2.16)3Mpl/J
001728   B6.WMP-Rb(3.12)4Mpl/J
014111   B6.WMP-Rb(3.12)4Mpl/JAmonJ
001729   B6.WMP-Rb(4.6)5Mpl/J
001732   B6.WMP-Rb(8.9)8Mpl/J
001796   B6Ei.Cg-Rb(1.2)18Lub/J
001921   B6Ei.Cg-Rb(1.7)1Rma/J
001386   B6Ei.Cg-Rb(10.12)5Lub/J
001617   B6Ei.Cg-Rb(10.15)23Lub/J
001795   B6Ei.Cg-Rb(11.13)4Bnr/J
000150   B6Ei.Cg-Rb(11.16)2H/J
000906   B6Ei.Cg-Rb(16.17)8Lub tw3Lub/+ +/J
001387   B6Ei.Cg-Rb(2.17)11Rma/J
001613   B6Ei.Cg-Rb(5.14)21Lub/J
001616   B6Ei.Cg-Rb(5.15)4Lub/J
001791   B6Ei.Cg-Rb(5.19)1Wh/J
000762   B6Ei.Cg-Rb(6.15)1Ald/J
001798   B6Ei.Cg-Rb(6.16)24Lub/J
001389   B6Ei.Cg-Rb(6.7)13Rma/J
001615   B6Ei.Cg-Rb(7.18)9Lub/J
001797   B6Ei.Cg-Rb(8.12)22Lub/J
000888   B6Ei.Cg-Rb(8.14)16Rma/J
001792   B6Ei.Cg-Rb(9.19)163H/J
001794   B6Ei.WMP-Rb(13.16)1Mpl/J
002470   B6EiC3Sn x B6-Rb(5.8)3Dn/J
004850   B6EiC3Sn-Rb(12.Ts171665Dn)2Cje/CjeDnJ
000975   C57BL/6J x STOCK Rb(1.3)1Ei/J
001391   C57BL/6J-Rb(4.15)1Rk/J
001390   C57BL/6J-Rb(6.18)2Dn/J
001793   C57BL/6JEi-Rb(X.2)2Ad/J
000714   CByJ.RBF-Rb(8.12)5Bnr
001802   CByJ.RBF-Rb(8.12)5Bnr/J
000609   RBB/DnJ
000889   RBC/DnJ
000862   STOCK Rb(1.7)1Rma/J
000891   STOCK Rb(10.11)5Rma/J
000614   STOCK Rb(10.11)8Bnr/J
000892   STOCK Rb(10.12)5Lub/J
000895   STOCK Rb(11.13)6Lub/J
001100   STOCK Rb(13.16)1Mpl/J
000615   STOCK Rb(16.17)7Bnr
003304   STOCK Rb(16.17)7Bnr-Myo15sh2-2J/J
000898   STOCK Rb(16.17)8Lub/J
000865   STOCK Rb(2.17)11Rma/J
000867   STOCK Rb(2.18)6Rma/J
000871   STOCK Rb(3.15)2Rk/J
000980   STOCK Rb(3.8)2Ei/J
000869   STOCK Rb(3.8)2Rma/J
000870   STOCK Rb(3.9)12Lub/J
000873   STOCK Rb(4.11)12Rma/J
000876   STOCK Rb(4.15)4Rma/J
000720   STOCK Rb(4.6)2Bnr/J
000878   STOCK Rb(5.14)21Lub/J
000880   STOCK Rb(5.15)15Rma/J
000881   STOCK Rb(5.17)7Rma/J
000882   STOCK Rb(5.19)1Wh/J
001884   STOCK Rb(5.6)1Ty/J
000885   STOCK Rb(6.16)24Lub
000887   STOCK Rb(8.12)22Lub/J
000613   STOCK Rb(9.19)163H/J
View Robertsonian Chromosome     (78 strains)

Strains carrying   Mc1rE-tob allele
001000   RBD/DnJ
000726   RBF/DnJ
000807   RBJ/DnJ
View Strains carrying   Mc1rE-tob     (3 strains)

Strains carrying   Rd3rd3 allele
008627   B6.Cg-Rd3rd3/Boc
000726   RBF/DnJ
000807   RBJ/DnJ
000852   STOCK In(5)30Rk/J
View Strains carrying   Rd3rd3     (4 strains)

Strains carrying other alleles of Mc1r
003625   B6.C-H2-Ab1bm12/KhEg-Mc1re-J/J
001434   C3HeB/FeJ x STX/Le-Mc1rE-so Gli3Xt-J Zeb1Tw/J
001533   C3HeB/FeJ-Mc1rE-so Gli3Xt-J/J
000060   C57BL/6J-Mc1re/J
View Strains carrying other alleles of Mc1r     (4 strains)

Strains carrying other alleles of Rb(11.13)4Bnr
014117   B6.Cg-Rb(11.13)4Bnr/JAmonJ
001795   B6Ei.Cg-Rb(11.13)4Bnr/J
001000   RBD/DnJ
000929   TIRANO/EiJ
001392   ZALENDE/EiJ
View Strains carrying other alleles of Rb(11.13)4Bnr     (5 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Albinism, Oculocutaneous, Type II; OCA2   (MC1R)
Leber Congenital Amaurosis 12; LCA12   (RD3)
Melanoma, Cutaneous Malignant, Susceptibility to, 5; CMM5   (MC1R)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Mc1rE-tob related

Endocrine Deficiency Research
Skin Defects

Rd3rd3 related

Sensorineural Research
Retinal Degeneration
      Homozygous for rd3

Genes & Alleles

Gene & Allele Information provided by MGI

 
Gene Symbol and Name Rb(11.13)4Bnr, Robertsonian translocation, Chr 11 and 13, Universitat Bonn/Rhein 4
Chromosome 13
Gene Common Name(s) Rb4Bnr;
 
Allele Symbol Mc1rE-tob
Allele Name tobacco darkening
Allele Type Spontaneous
Common Name(s) Etob;
Strain of OriginM. m. domesticus poschiavinus
Gene Symbol and Name Mc1r, melanocortin 1 receptor
Chromosome 8
Gene Common Name(s) CMM5; MSH-R; Mshra; SHEP2; Tob; e; extension recessive yellow; extension, recessive yellow; melanocyte hormone receptor alpha; tobacco darkening;
 
Allele Symbol Rd3rd3
Allele Name retinal degeneration 3
Allele Type Spontaneous
Strain of OriginRBF/DnJ
Gene Symbol and Name Rd3, retinal degeneration 3
Chromosome 1
Gene Common Name(s) 3322402L07Rik; C1orf36; LCA12; RIKEN cDNA 3322402L07 gene; rd-3;
General Note This mutation causes retinal degeneration. In homozygous mutant mice, development proceeds normally through the second postnatal week. Thereafter, photoreceptor and outer nuclear layers begin to degenerate, and by 8 weeks, no photoreceptor cells remain. Changes in electroretinograms parallel the histologic changes. As of 1998 this is the only type of retinal degeneration reported in mice in which the photoreceptors are initially normal (J:4367).
Molecular Note A C to T substitution in Rd3 results in a stop codon after residue 106. The truncated protein is initially expressed in in vitro assays but is degraded. [MGI Ref ID J:122439]
 
Gene Symbol and Name Rb(11.13)4Bnr, Robertsonian translocation, Chr 11 and 13, Universitat Bonn/Rhein 4
Chromosome 11
Gene Common Name(s) Rb4Bnr;

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Chang B; Hawes NL; Hurd RE; Davisson MT; Nusinowitz S; Heckenlively JR. 2002. Retinal degeneration mutants in the mouse. Vision Res 42(4):517-25. [PubMed: 11853768]  [MGI Ref ID J:75095]

Mc1rE-tob related

Gropp A; Tettenborn U; Lehmann E von. 1969. [Chromosome studies in the tobacco mouse (M. poschiavinus) and in tobacco mouse hybrids] Experientia 25(8):875-6. [PubMed: 5348563]  [MGI Ref ID J:24452]

Gropp A; Tettenborn U; Lehmann E von. 1970. [Chromosome variations on the Robertson type in the tobacco mouse, M. Poschiavinus, and its hybrids with the laboratory mouse] Cytogenetics 9(1):9-23. [PubMed: 5412048]  [MGI Ref ID J:23097]

Robbins LS; Nadeau JH; Johnson KR; Kelly MA; Roselli-Rehfuss L; Baack E; Mountjoy KG; Cone RD. 1993. Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function. Cell 72(6):827-34. [PubMed: 8458079]  [MGI Ref ID J:4636]

Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York.  [MGI Ref ID J:78801]

von Lehmann E. 1973. Coat colour genetics of the tobacco-mouse (Mus poschiavinus Fatio) Mouse News Lett 48:23.  [MGI Ref ID J:22593]

von Lehmann E. 1974. Weitere Mitteilungen zu: coat colour genetics of the tobacco-mouse (Mus poschiavinus Fatio). Mouse News Lett 50:26-7.  [MGI Ref ID J:13641]

Rd3rd3 related

Azadi S; Molday LL; Molday RS. 2010. RD3, the protein associated with Leber congenital amaurosis type 12, is required for guanylate cyclase trafficking in photoreceptor cells. Proc Natl Acad Sci U S A 107(49):21158-63. [PubMed: 21078983]  [MGI Ref ID J:167162]

Chang B; Hawes NL; Hurd RE; Davisson MT; Nusinowitz S; Heckenlively JR. 2002. Retinal degeneration mutants in the mouse. Vision Res 42(4):517-25. [PubMed: 11853768]  [MGI Ref ID J:75095]

Chang B; Hawes NL; Hurd RE; Wang J; Howell D; Davisson MT; Roderick TH; Nusinowitz S; Heckenlively JR. 2005. Mouse models of ocular diseases. Vis Neurosci 22(5):587-93. [PubMed: 16332269]  [MGI Ref ID J:156373]

Chang B; Heckenlively JR; Hawes NL; Roderick TH. 1993. New mouse primary retinal degeneration (rd-3). Genomics 16(1):45-9. [PubMed: 8486383]  [MGI Ref ID J:4367]

Cheng CL; Molday RS. 2013. Changes in gene expression associated with retinal degeneration in the rd3 mouse. Mol Vis 19:955-69. [PubMed: 23687432]  [MGI Ref ID J:202634]

Danciger M; Ogando D; Yang H; Matthes MT; Yu N; Ahern K; Yasumura D; Williams RW; Lavail MM. 2008. Genetic modifiers of retinal degeneration in the rd3 mouse. Invest Ophthalmol Vis Sci 49(7):2863-9. [PubMed: 18344445]  [MGI Ref ID J:136923]

Friedman JS; Chang B; Kannabiran C; Chakarova C; Singh HP; Jalali S; Hawes NL; Branham K; Othman M; Filippova E; Thompson DA; Webster AR; Andreasson S; Jacobson SG; Bhattacharya SS; Heckenlively JR; Swaroop A. 2006. Premature truncation of a novel protein, RD3, exhibiting subnuclear localization is associated with retinal degeneration. Am J Hum Genet 79(6):1059-70. [PubMed: 17186464]  [MGI Ref ID J:122439]

Hawes NL; Smith RS; Chang B; Davisson M; Heckenlively JR; John SW. 1999. Mouse fundus photography and angiography: a catalogue of normal and mutant phenotypes. Mol Vis 5:22. [PubMed: 10493779]  [MGI Ref ID J:59481]

Heckenlively JR; Chang B; Erway LC; Peng C; Hawes NL; Hageman GS; Roderick TH. 1995. Mouse model for Usher syndrome: linkage mapping suggests homology to Usher type I reported at human chromosome 11p15. Proc Natl Acad Sci U S A 92(24):11100-4. [PubMed: 7479945]  [MGI Ref ID J:121993]

Pieke-Dahl S; Ohlemiller KK; McGee J; Walsh EJ; Kimberling WJ. 1997. Hearing loss in the RBF/DnJ mouse, a proposed animal model of Usher syndrome type IIa. Hear Res 112(1-2):1-12. [PubMed: 9367224]  [MGI Ref ID J:44148]

Won J; Shi LY; Hicks W; Wang J; Hurd R; Naggert JK; Chang B; Nishina PM. 2011. Mouse model resources for vision research. J Ophthalmol 2011:391384. [PubMed: 21052544]  [MGI Ref ID J:166679]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           A1

Colony Maintenance

Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $258.15Female or MaleHomozygous for Rb(11.13)4Bnr  
Price per Pair (US dollars $)Pair Genotype
$516.25Homozygous for Rb(11.13)4Bnr x Homozygous for Rb(11.13)4Bnr  

Standard Supply

Research Strain. Availability determined by The Jackson Laboratory scientist holding the strain.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $335.60Female or MaleHomozygous for Rb(11.13)4Bnr  
Price per Pair (US dollars $)Pair Genotype
$671.20Homozygous for Rb(11.13)4Bnr x Homozygous for Rb(11.13)4Bnr  

Standard Supply

Research Strain. Availability determined by The Jackson Laboratory scientist holding the strain.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Research Strain. Availability determined by The Jackson Laboratory scientist holding the strain.

General Supply Notes

Important Note

This strain is homozygous for retinal degeneration 3, rd3.

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