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| This inbred strain bears a Robertsonian translocation, Rb(11.13)4Bnr, and a spontaneous eye mutation, Rd3rd3, and was derived from the sibling inbreeding of an F1 cross between a female from the outbred NMRI stock and a wild trapped Mus poschiavinus male from Val Poschiavo, Switzerland. It may be useful for studies of retinal degeneration, cancer, reproduction/meiosis, birth defects, aneuploidy generation, other genomic studies or genetic mapping. | |||||||||||||||||||
- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
- Health & care
- References
- Pricing & purchasing
- Terms of use
Description
Strain Information
Former Names Rb4Bnr (Changed: 15-DEC-04 ) Type Chromosome Aberration; Robertsonian; Additional information on Mice with Chromosomal Aberrations. Type Mutant Stock; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Mating System Homozygote x Homozygote (Female x Male) 01-MAR-06 Species laboratory mouse Appearance
albino
Related Genotype: Tyrc/Tyrc Mc1rE-tob/Mc1rE-tobImportant Note
This strain is homozygous for retinal degeneration 3, rd3.Description
This inbred strain bears a Robertsonian translocation, Rb(11.13)4Bnr, and a spontaneous eye mutation, Rd3rd3, and was derived from the sibling inbreeding of an F1 cross between a female from the outbred NMRI stock and a wild trapped Mus poschiavinus male from Val Poschiavo, Switzerland. It may be useful for studies of retinal degeneration, cancer, reproduction/meiosis, birth defects, aneuploidy generation, other genomic studies or genetic mapping.Development
Mus poschiavinus is a species of mouse found in Val Poschiavo, Switzerland. Its genome is organized in a karyotype of 26 chromosomes, instead of the usual 40. This includes 7 pairs of metacentrics, 5 pairs of acrocentrics, and the acrocentric X and Y (Cattanach et al., 1972). Due to the tobacco darkening allele (Mc1rE-tob) in this population, Mus poschiavinus mice have a black coat color that becomes agouti in the flanks after about 8 weeks of age.
In the late 1960s Alfred Gropp bred a Swiss NMRI female to a wild trapped male from Val Poschiavo, Switzerland and sent the F1 offspring to Frank Ruddle at Yale University who shipped these same F1 hybrids to Tom Roderick at The Jackson Laboratory. These F1 hybrids were sibling intercrossed and several inbred lines were generated from inbreeding of this population. These lines were selected for the presence Robertsonian translocations with the intention of generating inbred strains carrying a single Robertsonian or a defined set of Robertsonians. At F3 two lines separated: line PH was inbred to produce a line homozygous for Rb(16.17)7Bnr; and line PI was further separated at generation F4 into lines PAD and PAC. The PAC line was maintained by sibling intercross and the offspring of the F7 sibling intercross were separated into several further sublines, including PJG and PJI, which were each sibling intercrossed for one generation then cousin intercrossed before again being maintained by sibling intercross. In 1977 this line reached generation F17 and was designated subline N and in 1983 it reached generation F32. While this line was selected to be maintained homozygous for Rb(11.13)4Bnr, it had been maintained segregating for Mc1rE-tob and Tyrc, but at some point it became fixed homozygous for Tyrc. In 1990 when this inbred reached generation F73 an attempt was made to cryopreserve embryos but this was not successful. The strain remained on the shelf in the care of Norman Hawes & Bo Chang and they discovered the retinal degeneration 3 mutation (Rd3rd3) in it. Because this strain was inbred from an outbred population crossed to a wild male it has a unique genomic makeup compared with other inbred strains and even with other inbred strains derived from the same ancestral F1 population.
Related Strains
Robertsonian Chromosome
View Robertsonian Chromosome (67 strains)
008627 B6.Cg-Rd3rd3/Boc 000726 RBF/DnJ 000807 RBJ/DnJ 000852 STOCK In(5)30Rk/J
003625 B6.C-H2-Ab1bm12/KhEg-Mc1re-J/J 001434 C3HeB/FeJ x STX/Le-Mc1rE-so Gli3Xt-J Zeb1Tw/J 001533 C3HeB/FeJ-Mc1rE-so Gli3Xt-J/J 000060 C57BL/6J-Mc1re/J
001795 B6Ei.Cg-Rb(11.13)4Bnr/J 001000 RBD/DnJ 000929 TIRANO/EiJ 001392 ZALENDE/EiJ
Phenotype
Phenotype Information
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested. Albinism, Oculocutaneous, Type II; OCA2 (MC1R)
Leber Congenital Amaurosis 12; LCA12 (RD3)
Melanoma, Cutaneous Malignant, Susceptibility to, 5; CMM5 (MC1R)
This mouse can be used to support research in many areas including:Mc1rE-tob related
Rd3rd3 relatedEndocrine Deficiency Research
Skin Defects
Sensorineural Research
Retinal Degeneration
Homozygous for rd3
Genes & Alleles
Gene & Allele Information provided by MGI
| Gene Symbol and Name | Rb(11.13)4Bnr, Robertsonian translocation, Chr 11 and 13, Universitat Bonn/Rhein 4 | ||
|---|---|---|---|
| Chromosome | 13 | ||
| Gene Common Name(s) | Rb4Bnr; | ||
| Allele Symbol | Mc1rE-tob | ||
| Allele Name | tobacco darkening | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | Etob; | ||
| Strain of Origin | M. m. domesticus poschiavinus | ||
| Gene Symbol and Name | Mc1r, melanocortin 1 receptor | ||
| Chromosome | 8 | ||
| Gene Common Name(s) | CMM5; MSH-R; Mshra; SHEP2; Tob; e; extension recessive yellow; extension, recessive yellow; melanocyte hormone receptor alpha; tobacco darkening; | ||
| Allele Symbol | Rd3rd3 | ||
| Allele Name | retinal degeneration 3 | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | RBF/DnJ | ||
| Gene Symbol and Name | Rd3, retinal degeneration 3 | ||
| Chromosome | 1 | ||
| Gene Common Name(s) | 3322402L07Rik; C1orf36; LCA12; RIKEN cDNA 3322402L07 gene; rd-3; | ||
| General Note | This mutation causes retinal degeneration. In homozygous mutant mice, development proceeds normally through the second postnatal week. Thereafter, photoreceptor and outer nuclear layers begin to degenerate, and by 8 weeks, no photoreceptor cells remain. Changes in electroretinograms parallel the histologic changes. As of 1998 this is the only type of retinal degeneration reported in mice in which the photoreceptors are initially normal (J:4367). | ||
| Molecular Note | A C to T substitution in Rd3 results in a stop codon after residue 106. The truncated protein is initially expressed in in vitro assays but is degraded. [MGI Ref ID J:122439] | ||
| Gene Symbol and Name | Rb(11.13)4Bnr, Robertsonian translocation, Chr 11 and 13, Universitat Bonn/Rhein 4 | ||
| Chromosome | 11 | ||
| Gene Common Name(s) | Rb4Bnr; | ||
References
References provided by MGI
Additional References
Chang B; Hawes NL; Hurd RE; Davisson MT; Nusinowitz S; Heckenlively JR. 2002. Retinal degeneration mutants in the mouse. Vision Res 42(4):517-25. [PubMed: 11853768] [MGI Ref ID J:75095]
Mc1rE-tob relatedRd3rd3 relatedGropp A; Tettenborn U; Lehmann E von. 1969. [Chromosome studies in the tobacco mouse (M. poschiavinus) and in tobacco mouse hybrids] Experientia 25(8):875-6. [PubMed: 5348563] [MGI Ref ID J:24452]
Gropp A; Tettenborn U; Lehmann E von. 1970. [Chromosome variations on the Robertson type in the tobacco mouse, M. Poschiavinus, and its hybrids with the laboratory mouse] Cytogenetics 9(1):9-23. [PubMed: 5412048] [MGI Ref ID J:23097]
Robbins LS; Nadeau JH; Johnson KR; Kelly MA; Roselli-Rehfuss L; Baack E; Mountjoy KG; Cone RD. 1993. Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function. Cell 72(6):827-34. [PubMed: 8458079] [MGI Ref ID J:4636]
Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York. [MGI Ref ID J:78801]
von Lehmann E. 1973. Coat colour genetics of the tobacco-mouse (Mus poschiavinus Fatio) Mouse News Lett 48:23. [MGI Ref ID J:22593]
von Lehmann E. 1974. Weitere Mitteilungen zu: coat colour genetics of the tobacco-mouse (Mus poschiavinus Fatio). Mouse News Lett 50:26-7. [MGI Ref ID J:13641]
Azadi S; Molday LL; Molday RS. 2010. RD3, the protein associated with Leber congenital amaurosis type 12, is required for guanylate cyclase trafficking in photoreceptor cells. Proc Natl Acad Sci U S A 107(49):21158-63. [PubMed: 21078983] [MGI Ref ID J:167162]
Chang B; Hawes NL; Hurd RE; Davisson MT; Nusinowitz S; Heckenlively JR. 2002. Retinal degeneration mutants in the mouse. Vision Res 42(4):517-25. [PubMed: 11853768] [MGI Ref ID J:75095]
Chang B; Hawes NL; Hurd RE; Wang J; Howell D; Davisson MT; Roderick TH; Nusinowitz S; Heckenlively JR. 2005. Mouse models of ocular diseases. Vis Neurosci 22(5):587-93. [PubMed: 16332269] [MGI Ref ID J:156373]
Chang B; Heckenlively JR; Hawes NL; Roderick TH. 1993. New mouse primary retinal degeneration (rd-3). Genomics 16(1):45-9. [PubMed: 8486383] [MGI Ref ID J:4367]
Danciger M; Ogando D; Yang H; Matthes MT; Yu N; Ahern K; Yasumura D; Williams RW; Lavail MM. 2008. Genetic modifiers of retinal degeneration in the rd3 mouse. Invest Ophthalmol Vis Sci 49(7):2863-9. [PubMed: 18344445] [MGI Ref ID J:136923]
Friedman JS; Chang B; Kannabiran C; Chakarova C; Singh HP; Jalali S; Hawes NL; Branham K; Othman M; Filippova E; Thompson DA; Webster AR; Andreasson S; Jacobson SG; Bhattacharya SS; Heckenlively JR; Swaroop A. 2006. Premature truncation of a novel protein, RD3, exhibiting subnuclear localization is associated with retinal degeneration. Am J Hum Genet 79(6):1059-70. [PubMed: 17186464] [MGI Ref ID J:122439]
Hawes NL; Smith RS; Chang B; Davisson M; Heckenlively JR; John SW. 1999. Mouse fundus photography and angiography: a catalogue of normal and mutant phenotypes. Mol Vis 5:22. [PubMed: 10493779] [MGI Ref ID J:59481]
Heckenlively JR; Chang B; Erway LC; Peng C; Hawes NL; Hageman GS; Roderick TH. 1995. Mouse model for Usher syndrome: linkage mapping suggests homology to Usher type I reported at human chromosome 11p15. Proc Natl Acad Sci U S A 92(24):11100-4. [PubMed: 7479945] [MGI Ref ID J:121993]
Pieke-Dahl S; Ohlemiller KK; McGee J; Walsh EJ; Kimberling WJ. 1997. Hearing loss in the RBF/DnJ mouse, a proposed animal model of Usher syndrome type IIa. Hear Res 112(1-2):1-12. [PubMed: 9367224] [MGI Ref ID J:44148]
Won J; Shi LY; Hicks W; Wang J; Hurd R; Naggert JK; Chang B; Nishina PM. 2011. Mouse model resources for vision research. J Ophthalmol 2011:391384. [PubMed: 21052544] [MGI Ref ID J:166679]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number A1
Colony Maintenance
Mating System Homozygote x Homozygote (Female x Male) 01-MAR-06
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $232.00 Female or Male Homozygous for Rb(11.13)4Bnr
Price per Pair (US dollars $) Pair Genotype $464.00 Homozygous for Rb(11.13)4Bnr x Homozygous for Rb(11.13)4Bnr Standard Supply
Research Strain. Availability determined by The Jackson Laboratory scientist holding the strain.
| Pricing for International shipping destinations |
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Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $301.60 Female or Male Homozygous for Rb(11.13)4Bnr
Price per Pair (US dollars $) Pair Genotype $603.20 Homozygous for Rb(11.13)4Bnr x Homozygous for Rb(11.13)4Bnr Standard Supply
Research Strain. Availability determined by The Jackson Laboratory scientist holding the strain.
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Standard Supply
Research Strain. Availability determined by The Jackson Laboratory scientist holding the strain.
General Supply Notes
- This strain is included in the Eye Mutant Resource within the Mouse Mutant Resource collection.
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Important Note
This strain is homozygous for retinal degeneration 3, rd3.
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