Strain Name: |
MOLD/RkJ |
|---|---|
Stock Number: |
000734 |
Availability: | Repository- Live |
General Terms and Conditions |
| Former Name |
MOL 3-I (Changed: 15-DEC-04
) |
| Genes & Alleles | Pde6b; Pde6brd1; |
Product Information
Strain Details
Type Inbred Strain Additional information on Inbred Strains. Type Wild-Derived Additional information on Wild-Derived Mice. Mating System Sibling x Sibling (Female x Male) Species M. m. molossinus Generation F70+43 (07-DEC-07) Geographic Origin Fukuoka, Kyushu, Japan Appearance
white-bellied agouti
Related Genotype: Aw/AwImportant Note
This strain is homozygous for the retinal degeneration allele Pde6brd1.Strain Description
A 7 base pair deletion was reported in the Cd4 5' untranslated region of Stock No. 000550, MOLF/EiJ (Wade et al. 1993, Capparelli et al, 2004). Subsequent testing at The Jackson Laboratory indicated that MOLC/EiJ, MOLD/EiJ and MOLG/EiJ also carry the variant sequence. The deletion is not believed to affect expression.Strain Development
In 1969 Dr. Michael Potter at NCI sent to Dr. Thomas Roderick at The Jackson Laboratory 10 M. m. molossinus from a population that was within 1 to 3 generations of the wild population captured in Fukuoka, Kyushu, Japan. Dr. Roderick generated three inbred lines from single pairings of these mice and named them MOLC/Rk, MOLD/Rk, and MOLF/Rk. MOLC/Rk derived from the line he designated MOL 3-I, and MOLD/Rk and MOLE/Rk derived from the line designated MOL 3-III. (Roderick, 1982.)
Gene & Allele Details
| Allele Symbol | Pde6brd1 | ||
|---|---|---|---|
| Allele Name | retinal degeneration 1 | ||
| Common Name(s) | rd; rd-1; rd1; rodless retina; | ||
| Gene Symbol and Name | Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide | ||
| Chromosome | 5 | ||
| Gene Common Name(s) | CSNB3; PDEB; Pdeb; RP40; nmf137; phosphodiesterase, cGMP, rod receptor, beta polypeptide; r; rd; rd-1; rd1; rd10; retinal degeneration; retinal degeneration 1; retinal degeneration 10; | ||
| Molecular Note | Two mutations have been identified in rd1 mice. A murine leukimia virus (Xmv-28) insertion in reverse orientation in intron 1 is found in all mouse strains with the rd1 phenotype. Further, a nonsense mutation (C to A transversion) in codon 347 that results in a truncation eliminating more than half of the predicted encoded protein, including the catalytic domain has also been identified in all rd1 strains of mice. A specific degradation of mutant transcript during or after pre-mRNA splicing is suggested. [MGI Ref ID J:11513] [MGI Ref ID J:4366] [MGI Ref ID J:51361] | ||
Colony Maintenance
| Breeding & Husbandry | These mice are small and often need to wait until 4 weeks of age to wean. |
|---|
Related Strains
Strains carrying Pde6brd1 allele
View Strains carrying Pde6brd1 (74 strains)
004297 B6.CXB1-Pde6brd10/J 002802 C3.BLiA Pde6b+-Krd/J 001979 C3A.BLiA-Pde6b+.O20-Prph2Rd2/J 001912 C3A.BLiA-Pde6b+/J 003648 C3Sn.BLiA-Pde6b+/Dn 004766 C57BL/6J-Pde6brd1-2J/J 004828 FVB.129P2-Pde6b+ Tyrc-ch/AntJ 004808 STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
Phenotypic Data
Mouse Phenome Database
Additional Web Information
JAX® NOTES, Winter 1994; 456. Differences between MOLF/Ei, MOLD/Rk and MOLG/Dn.
JAX® NOTES, Winter 1995; 460. Wild-Derived Mice Strains - Tips on Their Care and Handling.
Animal Health Reports
Room Number A2A
Research Applications
This mouse can be used to support research in many areas including:
Pde6brd1 relatedResearch Tools
Genetics Research (Evolution and Systematics Research)
Genetics Research (Gene Mapping: Polymorphisms)
Sensorineural Research
Retinal Degeneration (Homozygous for Pde6brd1)
Mouse/Human Gene Homologs
retinitis pigmentosa, autosomal recessive
Sensorineural Research
Retinal Degeneration
References
Additional ReferencesPrice and Supply Information
| Strain Name: | MOLD/RkJ |
| Stock Number: | 000734 |
Price Details
IMPORTANT NOTE: Prices are based on shipping destination. To view prices, select your shipping destination.
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement. |
|---|---|
| Supply Notes |
Usually shipped between four and eight weeks of age. This strain is included in the Mouse Mutant Resource collection. Genomic DNA is available for this strain from the Mouse DNA Resource. |
| Licensing | See General Terms and Conditions below |
General Terms and Conditions
View JAX® Mice & Services Conditions of Use.
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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