Description

Strain Information

Type Recombinant Inbred (Ri); Additional information on Recombinant Inbred Mice. Mating System +/+ sibling x Hemizygote         (Female x Male) Species laboratory mouse RI progenitor C57BL/6J SB/Le H2 Haplotype b Generation F131 (13-MAY-08)

Appearance
white-bellied agouti, affected
Related Genotype: A^w/A^w X/Yaa (male)

white-bellied agouti, unaffected
Related Genotype: A^w/A^w X/X (female)

Important Note
This strain carries Yaa.

Description
Mice of the BXSB strain develop spontaneous autoimmune disease characterized by moderate lymph node and spleen enlargement, hemolytic anemia, hypergammaglobulinemia, and immune complex glomerulonephritis. The disease process in BXSB is strikingly accelerated in males, which live little more than a third as long as females. The acceleration is due to the presence of the Yaa gene on the Y chromosome. Similar acceleration occurs in males but not in females from an outcross of BXSB males to females of strain NZB. It does not occur in offspring of the reciprocal cross. The same effect of Yaa is seen in offspring of outcrosses to strains SJL, C57BL/6, and AKR. A dramatic increase in number of peripheral monocytes is seen in BXSB males beginning at 2 months of age. Males become deficient in pre-B-cells after about 4 weeks and remain so throughout life.

Control Information

	Control
	Female from the colony
	000742 BXSB.B6-Yaa+/J
	001925 BXSB.B6-Yaa+/MobJ
Considerations for Choosing Controls

Related Strains

Strains carrying   Yaa allele

000483

B6.SB-Yaa/J

View Strains carrying   Yaa     (1 strain)

Strains carrying other alleles of Yaa

000742	BXSB.B6-Yaa+/J
001925	BXSB.B6-Yaa+/MobJ

View Strains carrying other alleles of Yaa     (2 strains)

Additional Web Information

Genetic Quality Control Annual Report

Phenotype

Phenotype Information

View Phenotypic Data

Phenotypic Data

Mouse Phenome Database
Festing Inbred Strain Characteristics: BXSB

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms

Systemic Lupus Erythematosus; SLE -

View Mammalian Phenotype Terms

Mammalian Phenotype Terms

      assigned by genotype

X/Yaa

        BXSB

• life span-post-weaning/aging
• premature death (MGI Ref ID J:6235)
  • mean longevity for males is 155 +/- 13 days compared to 442 +/- 29 days for littermate females
  • castration does not significantly alter longevity
  • median survival is 8 months
• immune system phenotype
• abnormal B cell differentiation (MGI Ref ID J:108760)
  • frequency of C3d receptor bearing cells is increased in young mice but declines with age
• abnormal lymph node morphology (MGI Ref ID J:6235)
  • infiltrated with a mixed population of lymphocytes, plasma cells, and histiocytes often blurring the architecture of the node
• enlarged lymph nodes (MGI Ref ID J:6235)
  • moderately enlarged
  • at 18 to 25 weeks the combined weight of the axillary, mesenteric, and renal lymph nodes is increased 5-fold compared to C57BL/6J males
• glomerulonephritis (MGI Ref ID J:6235)
  • acute to subacute exudative and proliferative glomerulonephritis
• increased anti-erythrocyte antigen antibody level (MGI Ref ID J:6235)
  • erythrocyte autoantibodies were found in 7 of 13 males between 16 and 25 weeks of age
• increased monocyte cell number (MGI Ref ID J:7308)
  • increase in peripheral blood mononuclear cells lacking T and B cells markers is seen by 2 months of age and bemose more severe with age
  • at 8 months of age a 16-fold increase in monocytes is seen in males compared to females
• increased plasma cell number (MGI Ref ID J:108760)
  • increase in the frequency and absolute numbers of Ig-bearing cells associated with advanced autoimmune disease is seen in males but not females
  • frequency of Ig-bearing cells is increased in the thymus
• increased spleen weight (MGI Ref ID J:6235)
  • 4-fold increase in spleen weight
• increased susceptibility to autoimmune disorder (MGI Ref ID J:108760)
  • accelerated autoimmune syndrome relative to females of the same strain
• hematopoietic system phenotype
• abnormal B cell differentiation (MGI Ref ID J:108760)
  • frequency of C3d receptor bearing cells is increased in young mice but declines with age
• decreased erythrocyte cell number (MGI Ref ID J:6235)
  • decreased at 16 weeks of age compared to C57BL/6J males
• increased monocyte cell number (MGI Ref ID J:7308)
  • increase in peripheral blood mononuclear cells lacking T and B cells markers is seen by 2 months of age and bemose more severe with age
  • at 8 months of age a 16-fold increase in monocytes is seen in males compared to females
• increased plasma cell number (MGI Ref ID J:108760)
  • increase in the frequency and absolute numbers of Ig-bearing cells associated with advanced autoimmune disease is seen in males but not females
  • frequency of Ig-bearing cells is increased in the thymus
• increased spleen weight (MGI Ref ID J:6235)
  • 4-fold increase in spleen weight
• renal/urinary system phenotype
• glomerulonephritis (MGI Ref ID J:6235)
  • acute to subacute exudative and proliferative glomerulonephritis
• proteinuria (MGI Ref ID J:7308)
  • seen at 4 months of age
• homeostasis/metabolism phenotype
• proteinuria (MGI Ref ID J:7308)
  • seen at 4 months of age

X/Yaa

        BXSB/MpJScr

• life span-post-weaning/aging
• premature death (MGI Ref ID J:10973)
• immune system phenotype
• decreased CD4-positive T cell number (MGI Ref ID J:10973)
  • pronounced decrease in CD4+ T cells with age
• glomerulonephritis (MGI Ref ID J:10973)
  • develop severe proliferative glomerulonephritis by 3 to 5 months of age
• increased IgG level (MGI Ref ID J:10973)
• increased anti-nuclear antigen antibody level (MGI Ref ID J:10973)
  • anti-nuclear antibody levels are elevated at 3 to 5 months of age
• increased monocyte cell number (MGI Ref ID J:10973)
  • monocytosis
• increased susceptibility to autoimmune disorder (MGI Ref ID J:10973)
  • accelerated autoimmune syndrome
• hematopoietic system phenotype
• decreased CD4-positive T cell number (MGI Ref ID J:10973)
  • pronounced decrease in CD4+ T cells with age
• increased monocyte cell number (MGI Ref ID J:10973)
  • monocytosis
• renal/urinary system phenotype
• glomerulonephritis (MGI Ref ID J:10973)
  • develop severe proliferative glomerulonephritis by 3 to 5 months of age

The following phenotype information may relate to a genetic background differing from this JAX^® Mice strain.

X/Yaa

        (SJL/J x BXSB)F1

• life span-post-weaning/aging
• premature death (MGI Ref ID J:6235)
  • mean longevity for males is 308 +/- 26 days while only 8 of 16 reciprocal hybrid males died between 270 and 684 days
• immune system phenotype
• enlarged lymph nodes (MGI Ref ID J:6235)
  • moderately enlarged
  • at 18 to 25 weeks the combined weight of the axillary, mesenteric, and renal lymph nodes is increased 5-fold compared to C57BL/6J males
• increased susceptibility to autoimmune disorder (MGI Ref ID J:6235)
  • accelerated autoimmune syndrome relative to reciprocal hybrid males

X/Yaa

        (C57BL/6J x BXSB)F1

• life span-post-weaning/aging
• premature death (MGI Ref ID J:6235)
  • mean longevity for males is 332 +/- 14 days compared to 716 +/- 28 days for littermate females
• immune system phenotype
• enlarged lymph nodes (MGI Ref ID J:6235)
  • moderately enlarged
  • at 18 to 25 weeks the combined weight of the axillary, mesenteric, and renal lymph nodes is increased 5-fold compared to C57BL/6J males
• increased susceptibility to autoimmune disorder (MGI Ref ID J:6235)
  • accelerated autoimmune syndrome relative to reciprocal hybrid males

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Yaa related

Immunology and Inflammation Research
Autoimmunity (lupus erythematosus)

Genes & Alleles

Gene & Allele Information

Allele Symbol		Yaa
Allele Name		accelerated autoimmunity and lymphoproliferation
Allele Type		Spontaneous
Common Name(s)		Tp(X;Y)1Ekw;
Strain of Origin		SB/Le
Gene Symbol and Name		Yaa, accelerated autoimmunity and lymphoproliferation transposition
Chromosome		Y
Gene Common Name(s)		Tp(X;Y)1Ekw;
General Note		In congenic C57BL/6 Yaa mice expression of Tlr7 is increased 2-fold.
Molecular Note		A region of the X chromosome that includes Tlr7 and Prps2 is translocated to the Y chromosome. [MGI Ref ID J:111064] [MGI Ref ID J:140028]

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Optimizing PCR Protocols

References

References

Additional References

Andrews BS; Eisenberg RA; Theofilopoulos AN; Izui S; Wilson CB; McConahey PJ; Murphy ED; Roths JB; Dixon FJ. 1978. Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains. J Exp Med 148(5):1198-215. [PubMed: 309911]  [MGI Ref ID J:27634]

Eisenberg RA; Izui S; McConahey PJ; Hang L; Peters CJ; Theofilopoulos AN; Dixon FJ. 1980. Male determined accelerated autoimmune disease in BXSB mice: transfer by bone marrow and spleen cells. J Immunol 125(3):1032-6. [PubMed: 7410826]  [MGI Ref ID J:6372]

Gilbert D; Lopez B; Parain J; Koutouzov S; Tron F. 2000. Overlap of the anti-cardiolipin and anti-nucleosome responses of the (NZW X BXSB)F1 mouse strain: a new pattern of cross-reactivity for lupus-related autoantibodies Eur J Immunol 30(11):3271-80. [PubMed: 11093143]  [MGI Ref ID J:65821]

Luzina IG; Atamas SP; Storrer CE; daSilva LC; Kelsoe G; Papadimitriou JC; Handwerger BS. 2001. Spontaneous formation of germinal centers in autoimmune mice. J Leukoc Biol 70(4):578-84. [PubMed: 11590194]  [MGI Ref ID J:72513]

Murphy ED; Roths JB. 1979. A Y chromosome associated factor in strain BXSB producing accelerated autoimmunity and lymphoproliferation. Arthritis Rheum 22(11):1188-94. [PubMed: 315777]  [MGI Ref ID J:6235]

Yaa related

Anders HJ; Krug A; Pawar RD. 2008. Molecular mimicry in innate immunity? The viral RNA recognition receptor TLR7 accelerates murine lupus. Eur J Immunol 38(7):1795-9. [PubMed: 18581336]  [MGI Ref ID J:137453]

Arabo A; Costa O; Tron F; Caston J. 2005. Spatial and motor abilities during the course of autoimmune disease in (NZW x BXSB)F1 lupus-prone mice. Behav Brain Res 165(1):126-37. [PubMed: 16168499]  [MGI Ref ID J:115747]

Boehm GW; Sherman GF; Hoplight BJ 2nd; Hyde LA; Bradway DM; Galaburda AM; Ahmed SA; Denenberg VH. 1998. Learning in year-old female autoimmune BXSB mice. Physiol Behav 64(1):75-82. [PubMed: 9661985]  [MGI Ref ID J:49007]

Denenberg VH; Hoplight B; Sherman GF; Mobraaten LE. 2001. Effects of the uterine environment and neocortical ectopias upon behavior of BXSB-Yaa+mice. Dev Psychobiol 38(3):154-63. [PubMed: 11279592]  [MGI Ref ID J:72331]

Denenberg VH; Sherman G; Schrott LM; Waters NS; Boehm GW; Galaburda AM; Mobraaten LE. 1996. Effects of embryo transfer and cortical ectopias upon the behavior of BXSB-Yaa and BXSB-Yaa + mice. Brain Res Dev Brain Res 93(1-2):100-8. [PubMed: 8804696]  [MGI Ref ID J:33655]

Eisenberg RA; Izui S; McConahey PJ; Hang L; Peters CJ; Theofilopoulos AN; Dixon FJ. 1980. Male determined accelerated autoimmune disease in BXSB mice: transfer by bone marrow and spleen cells. J Immunol 125(3):1032-6. [PubMed: 7410826]  [MGI Ref ID J:6372]

Fairhurst AM; Hwang SH; Wang A; Tian XH; Boudreaux C; Zhou XJ; Casco J; Li QZ; Connolly JE; Wakeland EK. 2008. Yaa autoimmune phenotypes are conferred by overexpression of TLR7. Eur J Immunol 38(7):1971-8. [PubMed: 18521959]  [MGI Ref ID J:137309]

Fossati L; Iwamoto M; Merino R; Izui S. 1995. Selective enhancing effect of the Yaa gene on immune responses against self and foreign antigens. Eur J Immunol 25(1):166-73. [PubMed: 7843228]  [MGI Ref ID J:22499]

Fossati L; Sobel ES; Iwamoto M; Cohen PL; Eisenberg RA; Izui S. 1995. The Yaa gene-mediated acceleration of murine lupus: Yaa- T cells from non-autoimmune mice collaborate with Yaa+ B cells to produce lupus autoantibodies in vivo. Eur J Immunol 25(12):3412-7. [PubMed: 8566031]  [MGI Ref ID J:31227]

Hang LM; Izui S; Dixon FJ. 1981. (NZW x BXSB)F1 hybrid. A model of acute lupus and coronary vascular disease with myocardial infarction. J Exp Med 154(1):216-21. [PubMed: 7252427]  [MGI Ref ID J:38157]

Hudgins CC; Steinberg RT; Klinman DM; Reeves MJ; Steinberg AD. 1985. Studies of consomic mice bearing the Y chromosome of the BXSB mouse. J Immunol 134(6):3849-54. [PubMed: 3989299]  [MGI Ref ID J:7823]

Hugin AW; Fossati-Jimack L; Izui S. 2000. The autoimmune accelerating yaa mutation does not accelerate murine AIDS. Cell Immunol 200(2):76-80. [PubMed: 10753498]  [MGI Ref ID J:114277]

Hyde LA; Stavnezer AJ; Bimonte HA; Sherman GF; Denenberg VH. 2002. Spatial and nonspatial Morris maze learning: impaired behavioral flexibility in mice with ectopias located in the prefrontal cortex. Behav Brain Res 133(2):247-59. [PubMed: 12110458]  [MGI Ref ID J:108472]

Izui S; Masuda K; Yoshida H. 1984. Acute SLE in F1 hybrids between SB/Le and NZW mice; prominently enhanced formation of gp70 immune complexes by a Y chromosome-associated factor from SB/Le mice. J Immunol 132(2):701-4. [PubMed: 6690614]  [MGI Ref ID J:7276]

Izui S; Merino R; Fossati L; Iwamoto M. 1994. The role of the Yaa gene in lupus syndrome. Int Rev Immunol 11(3):211-30. [PubMed: 7930846]  [MGI Ref ID J:21990]

Jansson L; Holmdahl R. 1994. The Y chromosome-linked autoimmune accelerating yaa gene suppresses collagen-induced arthritis. Eur J Immunol 24(5):1213-7. [PubMed: 8181531]  [MGI Ref ID J:18810]

Kamada H; Takaoka Y; Kitagaki K; Nagai H. 1995. Effect of cyclophosphamide on lymphokine production in MRL/lpr.Yaa mice. Inflamm Res 44(11):491-8. [PubMed: 8597884]  [MGI Ref ID J:30518]

Kawano H; Abe M; Zhang D; Saikawa T; Fujimori M; Hirose S; Shirai T. 1992. Heterozygosity of the major histocompatibility complex controls the autoimmune disease in (NZW x BXSB) F1 mice. Clin Immunol Immunopathol 65(3):308-14. [PubMed: 1451334]  [MGI Ref ID J:3381]

Khaled AR; Butfiloski EJ; Villas B; Sobel ES; Schiffenbauer J. 1999. Aberrant expression of the NF-kappaB and IkappaB proteins in B cells from viable motheaten mice. Autoimmunity 30(2):115-28. [PubMed: 10435725]  [MGI Ref ID J:117314]

Kikuchi S; Amano H; Amano E; Fossati-Jimack L; Santiago-Raber ML; Moll T; Ida A; Kotzin BL; Izui S. 2005. Identification of 2 major loci linked to autoimmune hemolytic anemia in NZB mice. Blood 106(4):1323-9. [PubMed: 15860660]  [MGI Ref ID J:117292]

Kikuchi S; Fossati-Jimack L; Moll T; Amano H; Amano E; Ida A; Ibnou-Zekri N; Laporte C; Santiago-Raber ML; Rozzo SJ; Kotzin BL; Izui S. 2005. Differential role of three major New Zealand black-derived loci linked with Yaa-induced murine lupus nephritis. J Immunol 174(2):1111-7. [PubMed: 15634937]  [MGI Ref ID J:95829]

Kikuchi S; Santiago-Raber ML; Amano H; Amano E; Fossati-Jimack L; Moll T; Kotzin BL; Izui S. 2006. Contribution of NZB autoimmunity 2 to Y-linked autoimmune acceleration-induced monocytosis in association with murine systemic lupus. J Immunol 176(5):3240-7. [PubMed: 16493085]  [MGI Ref ID J:129409]

Kofler R; McConahey PJ; Duchosal MA; Balderas RS; Theofilopoulos AN; Dixon FJ. 1991. An autosomal recessive gene that delays expression of lupus in BXSB mice. J Immunol 146(4):1375-9. [PubMed: 1991974]  [MGI Ref ID J:10973]

Kono DH; Balomenos D; Park MS; Theofilopoulos AN. 2000. Development of lupus in BXSB mice is independent of IL-4. J Immunol 164(1):38-42. [PubMed: 10604990]  [MGI Ref ID J:112421]

Kuroki A; Moll T; Lopez-Hoyos M; Fossati-Jimack L; Ibnou-Zekri N; Kikuchi S; Merino J; Merino R; Izui S. 2004. Enforced Bcl-2 expression in B lymphocytes induces rheumatoid factor and anti-DNA production, but the Yaa mutation promotes only anti-DNA production. Eur J Immunol 34(4):1077-84. [PubMed: 15048718]  [MGI Ref ID J:88856]

Leiter EH; Prochazka M; Shultz LD. 1987. Effect of immunodeficiency on diabetogenesis in genetically diabetic (db/db) mice. J Immunol 138(10):3224-9. [PubMed: 3553324]  [MGI Ref ID J:32752]

Lin Q; Xiu Y; Jiang Y; Tsurui H; Nakamura K; Kodera S; Ohtsuji M; Ohtsuji N; Shiroiwa W; Tsukamoto K; Amano H; Amano E; Kinoshita K; Sudo K; Nishimura H; Izui S; Shirai T; Hirose S. 2006. Genetic dissection of the effects of stimulatory and inhibitory IgG Fc receptors on murine lupus. J Immunol 177(3):1646-54. [PubMed: 16849473]  [MGI Ref ID J:137977]

Merino R; Fossati L; Lacour M; Lemoine R; Higaki M; Izui S. 1992. H-2-linked control of the Yaa gene-induced acceleration of lupus-like autoimmune disease in BXSB mice. Eur J Immunol 22(2):295-9. [PubMed: 1537372]  [MGI Ref ID J:2011]

Merino R; Iwamoto M; Gershwin ME; Izui S. 1994. The Yaa gene abrogates the major histocompatibility complex association of murine lupus in (NZB x BXSB)F1 hybrid mice. J Clin Invest 94(2):521-5. [PubMed: 8040305]  [MGI Ref ID J:19547]

Merino R; Shibata T; De Kossodo S; Izui S. 1989. Differential effect of the autoimmune Yaa and lpr genes on the acceleration of lupus-like syndrome in MRL/MpJ mice. Eur J Immunol 19(11):2131-7. [PubMed: 2599002]  [MGI Ref ID J:108759]

Moll T; Martinez-Soria E; Santiago-Raber ML; Amano H; Pihlgren-Bosch M; Marinkovic D; Izui S. 2005. Differential activation of anti-erythrocyte and anti-DNA autoreactive B lymphocytes by the Yaa mutation. J Immunol 174(2):702-9. [PubMed: 15634889]  [MGI Ref ID J:132847]

Morel L; Croker BP; Blenman KR; Mohan C; Huang G; Gilkeson G; Wakeland EK. 2000. Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains. Proc Natl Acad Sci U S A 97(12):6670-5. [PubMed: 10841565]  [MGI Ref ID J:62719]

Murphy ED; Roths JB. 1979. A Y chromosome associated factor in strain BXSB producing accelerated autoimmunity and lymphoproliferation. Arthritis Rheum 22(11):1188-94. [PubMed: 315777]  [MGI Ref ID J:6235]

Ozaki K; Spolski R; Ettinger R; Kim HP; Wang G; Qi CF; Hwu P; Shaffer DJ; Akilesh S; Roopenian DC; Morse HC rd; Lipsky PE; Leonard WJ. 2004. Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6. J Immunol 173(9):5361-71. [PubMed: 15494482]  [MGI Ref ID J:93740]

Pisetsky DS; Klatt C; Dawson D; Roths JB. 1985. The influence of Yaa on anti-DNA responses of B6-lpr mice. Clin Immunol Immunopathol 37(3):369-76. [PubMed: 3931946]  [MGI Ref ID J:109825]

Rosenblatt N; Hartmann KU; Loor F. 1994. The Yaa gene-dependent B-cell deficiency worsens the generalized lymphadenopathy and autoimmunity of C57BL/6-gld male mice. Immunology 83(3):476-83. [PubMed: 7835973]  [MGI Ref ID J:21189]

Rosenblatt N; Hartmann KU; Loor F. 1994. The Yaa mutation induces the development of autoimmunity in mice heterozygous for the gld (generalized lymphadenopathy disease) mutation. Cell Immunol 156(2):519-28. [PubMed: 8025960]  [MGI Ref ID J:19169]

Santiago ML; Fossati L; Jacquet C; Muller W; Izui S; Reininger L. 1997. Interleukin-4 protects against a genetically linked lupus-like autoimmune syndrome. J Exp Med 185(1):65-70. [PubMed: 8996242]  [MGI Ref ID J:37574]

Santiago ML; Mary C; Parzy D; Jacquet C; Montagutelli X; Parkhouse RM; Lemoine R; Izui S; Reininger L. 1998. Linkage of a major quantitative trait locus to Yaa gene-induced lupus-like nephritis in (NZW x C57BL/6)F1 mice. Eur J Immunol 28(12):4257-67. [PubMed: 9862363]  [MGI Ref ID J:52110]

Santiago-Raber ML; Kikuchi S; Borel P; Uematsu S; Akira S; Kotzin BL; Izui S. 2008. Evidence for genes in addition to Tlr7 in the Yaa translocation linked with acceleration of systemic lupus erythematosus. J Immunol 181(2):1556-62. [PubMed: 18606711]  [MGI Ref ID J:137656]

Schrott LM; Waters NS; Boehm GW; Sherman GF; Morrison L; Rosen GD; Behan PO; Galaburda AM; Denenberg VH. 1993. Behavior, cortical ectopias, and autoimmunity in BXSB-Yaa and BXSB-Yaa+ mice. Brain Behav Immun 7(3):205-23. [PubMed: 8147964]  [MGI Ref ID J:14455]

Shimizu M; Sekine K; Matsuzawa A; Iwaguchi T. 1992. Cell electrophoretic characterization of abnormally expanded lymphocytes in autoimmune lprcg, lpr, gld and Yaa mice, and of thymocyte subsets. Electrophoresis 13(3):136-42. [PubMed: 1592043]  [MGI Ref ID J:2361]

Smith HR; Chused TM; Steinberg AD. 1983. The effect of the X-linked immune deficiency gene (xid) upon the Y chromosome-related disease of BXSB mice. J Immunol 131(3):1257-62. [PubMed: 6886419]  [MGI Ref ID J:7172]

Subramanian S; Tus K; Li QZ; Wang A; Tian XH; Zhou J; Liang C; Bartov G; McDaniel LD; Zhou XJ; Schultz RA; Wakeland EK. 2006. A Tlr7 translocation accelerates systemic autoimmunity in murine lupus. Proc Natl Acad Sci U S A 103(26):9970-5. [PubMed: 16777955]  [MGI Ref ID J:111064]

Suzuki H; Yasukawa K; Saito T; Narazaki M; Hasegawa A; Taga T; Kishimoto T. 1993. Serum soluble interleukin-6 receptor in MRL/lpr mice is elevated with age and mediates the interleukin-6 signal. Eur J Immunol 23(5):1078-82. [PubMed: 8477802]  [MGI Ref ID J:4970]

Taguchi N; Hashimoto Y; Naiki M; Farr AG; Boyd RL; Ansari AA; Shultz LD; Kotzin BL; Dorshkind K; Ikehara S; Gershwin ME. 1999. Abnormal thymic expression of epithelial cell adhesion molecule (EP-CAM) in New Zealand Black (NZB) mice. J Autoimmun 13(4):393-404. [PubMed: 10585755]  [MGI Ref ID J:59174]

Takahashi S; Fossati L; Iwamoto M; Merino R; Motta R; Kobayakawa T; Izui S. 1996. Imbalance towards Th1 predominance is associated with acceleration of lupus-like autoimmune syndrome in MRL mice. J Clin Invest 97(7):1597-604. [PubMed: 8601623]  [MGI Ref ID J:32235]

Takeoka Y; Taguchi N; Shultz L; Boyd RL; Naiki M; Ansari AA; Gershwin ME. 1999. Apoptosis and the thymic microenvironment in murine lupus. J Autoimmun 13(3):325-34. [PubMed: 10550220]  [MGI Ref ID J:58407]

Teuscher C; Noubade R; Spach K; McElvany B; Bunn JY; Fillmore PD; Zachary JF; Blankenhorn EP. 2006. Evidence that the Y chromosome influences autoimmune disease in male and female mice. Proc Natl Acad Sci U S A 103(21):8024-9. [PubMed: 16702550]  [MGI Ref ID J:110221]

Theofilopoulos AN; Eisenberg RA; Bourdon M; Crowell JS Jr; Dixon FJ. 1979. Distribution of lymphocytes identified by surface markers in murine strains with systemic lupus erythematosus-like syndromes. J Exp Med 149(2):516-34. [PubMed: 762500]  [MGI Ref ID J:108760]

Wilber A; O'Connor TP; Lu ML; Karimi A; Schneider MC. 2003. Dnase1l3 deficiency in lupus-prone MRL and NZB/W F1 mice. Clin Exp Immunol 134(1):46-52. [PubMed: 12974753]  [MGI Ref ID J:109815]

Wofsy D; Kerger CE; Seaman WE. 1984. Monocytosis in the BXSB model for systemic lupus erythematosus. J Exp Med 159(2):629-34. [PubMed: 6363600]  [MGI Ref ID J:7308]

Yoh K; Shibuya K; Morito N; Nakano T; Ishizaki K; Shimohata H; Nose M; Izui S; Shibuya A; Koyama A; Engel JD; Yamamoto M; Takahashi S. 2003. Transgenic overexpression of GATA-3 in T lymphocytes improves autoimmune glomerulonephritis in mice with a BXSB/MpJ-Yaa genetic background. J Am Soc Nephrol 14(10):2494-502. [PubMed: 14514727]  [MGI Ref ID J:131473]

Zhang MC; Furukawa H; Tokunaka K; Saiga K; Date F; Owada Y; Nose M; Ono M. 2008. Mast cell hyperplasia in the skin of Dsg4-deficient hypotrichosis mice, which are long-living mutants of lupus-prone mice. Immunogenetics 60(10):599-607. [PubMed: 18677469]  [MGI Ref ID J:140028]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX11

Colony Maintenance

Mating System	+/+ sibling x Hemizygote         (Female x Male)
Diet Information	LabDiet® 5K54

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Supply Details

Standard Supply	Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.
Supply Notes	Usually shipped between four and eight weeks of age. This strain is included in the Mouse Mutant Resource collection. Genomic DNA is available for this strain from the Mouse DNA Resource.
Important Note	This strain carries Yaa.

Control Information

	Control
	Female from the colony
	000742 BXSB.B6-Yaa+/J
	001925 BXSB.B6-Yaa+/MobJ
Considerations for Choosing Controls
USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
International - Control Pricing Information for Genetically Engineered Mutant Strains.

General Terms and Conditions

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Ordering and Purchasing Information

      Purchasing Information
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Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
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Terms of Use

Terms of Use

General Terms and Conditions

Contact information

General inquiries

Contracts Administration

phone:	207-288-6470
fax:	207-288-6655

JAX^® Mice & Services Conditions of Use

“Each recipient institution, including its employees and other researchers under its control (RECIPIENT), of mice or services using mice from The Jackson Laboratory (TJL) agrees that such mice, descendants of those mice derived by inbreeding or crossbreeding, including unmodified derivatives of those mice or their descendants (“MICE”) shall not be: (i) used for any purpose other than the internal research of the RECIPIENT, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services with respect to MICE. Acceptance of MICE from TJL shall be deemed agreement by RECIPIENT to these conditions, and departure from these conditions requires The Jackson Laboratory’s prior written authorization.”

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of MICE, products or services, The Jackson Laboratory will, at its option, provide credit or replacement for the MICE or product received or the services provided.

No Liability

In no event shall The Jackson Laboratory, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, products or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of The Jackson Laboratory, its agents or employees. In purchasing or receiving MICE, products or services from The Jackson Laboratory, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges The Jackson Laboratory from all such causes of action or damages, and further agrees to defend and indemnify The Jackson Laboratory from any costs or damages arising out of any third party claims.

MICE and biological materials are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to The Jackson Laboratory’s MICE, products and services. In addition, special terms and conditions of sale of certain MICE, products and services may be set forth separately in The Jackson Laboratory web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, products and services by The Jackson Laboratory, and by its licensees and distributors.

Acceptance of delivery of MICE, products or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on The Jackson Laboratory, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, products services by The Jackson Laboratory.