Description

Strain Information

Type Recombinant Inbred (RI); Additional information on Recombinant Inbred Mice. Visit our online Nomenclature tutorial. Mating System +/+ sibling x Hemizygote         (Female x Male)   01-MAR-06 Species laboratory mouse RI progenitor C57BL/6J SB/Le H2 Haplotype b Generation F144 (16-MAR-11) Generation Definitions

Appearance
white-bellied agouti, affected
Related Genotype: A^w/A^w X/Yaa (male)

white-bellied agouti, unaffected
Related Genotype: A^w/A^w X/X (female)

Important Note
Males of this strain carry the BXSB-derived Yaa mutation on the Y chromosome.

Description
The Y-linked autoimmune acceleration (Yaa) locus on the Y chromosome of BXSB inbred male mice is the result of a duplication of an ~4 Mbp telomeric segment near the pseudoautosomal region of the X chromosome onto the Y chromosome. The duplicated segment contains 19 genes, including toll-like receptor 7 (Tlr7) and phosphoribosyl pyrophosphate synthetase 2 (Prps2). BXSB males have the mutant Yaa-containing Y chromosome, and are a model for a severe form of systemic lupus erythematosus (SLE). Their spontaneously arising autoimmune disease is characterized by the robust development of follicular T cells and germinal centers. Marginal zone B cells are depleted in BXSB-Yaa mice and a dramatic increase in number of peripheral monocytes is seen beginning at two months of age. Disease progression is characterized by lymph node and spleen enlargement, hemolytic anemia, hypergammaglobulinemia, anti-nuclear antibodies, and immune complex glomerulonephritis. This leads to morbidity on average of six months of age. BXSB females develop a greatly attenuated form of autoimmune disease; indicating that autoimmune disease acceleration is due to the presence of the Yaa mutation carried on the Y chromosome.

A duplicated copy of the Tlr7 gene is primarily responsible for the autoimmune phenotype attributed to the Yaa mutation. The BXSB-Yaa mouse therefore provides a model for investigating the effects copy number variation of Tlr7 on autoimmune disease. Therapeutic treatment of BXSB-Yaa mice with an anti-Type I interferon receptor antibody attenuates their autoimmune disease; indicating that Type I interferon signaling involved is in the pathogenesis of this disease.

In addition, BXSB males lacking the interleukin 21 receptor (BXSB-Yaa/Il21r^-/- or BXSB-Yaa/Il21^-/-) are highly resistant to disease and are therefore a model for investigating the role of interleukin 21 in disease pathogenesis. Populations of regulatory CD8+ and potentially natural killer cells are also actively retarding disease in this model; making them useful to investigate the roles of such regulatory cells in autoimmune disease.

A note on outcrossing BXSB males with other inbred females, similar autoimmune disease acceleration occurs in males (but not in females) from an outcross of BXSB males to NZB females. Acceleration does not occur in offspring of the reciprocal cross. The same effect of Yaa is seen in offspring of outcrosses to strains SJL, C57BL/6, and AKR.

Control Information

	Control
	Female from the colony
	See control note:	The most suitable control animals are sex-matched, autoimmune disease-resistant BXSB.B6-Yaa+ consomic males carrying the C57BL/6-derived Y chromosome in place of the BXSB-derived mutant Yaa-containing Y chromosome. BXSB.B6-Yaa+ consomic mice are available with different amounts of backcrossing to BXSB/MpJ inbred females: --Stock No. 021330 are backcrossed at least 40 generations, --Stock No. 001925 are backcrossed at least 22 generations, and --Stock No. 000742 are backcrossed at least 10 generations.
	000742 BXSB.B6-Yaa+/J
	001925 BXSB.B6-Yaa+/MobJ
Considerations for Choosing Controls

Related Strains

BXSB Strain

021330

BXSB.B6-Yaa+/MobJDcrJ

View BXSB Strain     (1 strain)

Strains carrying   Yaa allele

000483

B6.SB-Yaa/J

View Strains carrying   Yaa     (1 strain)

Strains carrying other alleles of Yaa

000742	BXSB.B6-Yaa+/J
001925	BXSB.B6-Yaa+/MobJ
021330	BXSB.B6-Yaa+/MobJDcrJ

View Strains carrying other alleles of Yaa     (3 strains)

Additional Web Information

JAX^® NOTES, Summer 2009; 514. JAX Researcher Identifies Critical Role of IL21 in Lupus Pathogenesis.

Phenotype

Phenotype Information

View Phenotypic Data

Phenotypic Data

Mouse Phenome Database
Festing Inbred Strain Characteristics: BXSB

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI

- Characteristics of this human disease are associated with transgenes and other mutation types in the mouse.

Systemic Lupus Erythematosus; SLE

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI

      assigned by genotype

X/Yaa

        BXSB/MpJ

• mortality/aging
• premature death
  • mean longevity for males is 155 +/- 13 days compared to 442 +/- 29 days for littermate females   (MGI Ref ID J:6235)
  • castration does not significantly alter longevity   (MGI Ref ID J:6235)
  • median survival is 8 months   (MGI Ref ID J:7308)
• immune system phenotype
• abnormal B cell differentiation
  • frequency of C3d receptor bearing cells is increased in young mice but declines with age   (MGI Ref ID J:108760)
• abnormal lymph node morphology
  • infiltrated with a mixed population of lymphocytes, plasma cells, and histiocytes often blurring the architecture of the node   (MGI Ref ID J:6235)
• • enlarged lymph nodes
    • moderately enlarged   (MGI Ref ID J:6235)
    • at 18 to 25 weeks the combined weight of the axillary, mesenteric, and renal lymph nodes is increased 5-fold compared to C57BL/6J males   (MGI Ref ID J:6235)
• glomerulonephritis
  • acute to subacute exudative and proliferative glomerulonephritis   (MGI Ref ID J:6235)
• increased anti-erythrocyte antigen antibody level
  • erythrocyte autoantibodies were found in 7 of 13 males between 16 and 25 weeks of age   (MGI Ref ID J:6235)
• increased monocyte cell number
  • increase in peripheral blood mononuclear cells lacking T and B cells markers is seen by 2 months of age and bemose more severe with age   (MGI Ref ID J:7308)
  • at 8 months of age a 16-fold increase in monocytes is seen in males compared to females   (MGI Ref ID J:7308)
• increased plasma cell number
  • increase in the frequency and absolute numbers of Ig-bearing cells associated with advanced autoimmune disease is seen in males but not females   (MGI Ref ID J:108760)
  • frequency of Ig-bearing cells is increased in the thymus   (MGI Ref ID J:108760)
• increased spleen weight
  • 4-fold increase in spleen weight   (MGI Ref ID J:6235)
• increased susceptibility to autoimmune disorder   (MGI Ref ID J:108760)
  • accelerated autoimmune syndrome relative to females of the same strain   (MGI Ref ID J:6235)
• hematopoietic system phenotype
• abnormal B cell differentiation
  • frequency of C3d receptor bearing cells is increased in young mice but declines with age   (MGI Ref ID J:108760)
• decreased erythrocyte cell number
  • decreased at 16 weeks of age compared to C57BL/6J males   (MGI Ref ID J:6235)
• increased monocyte cell number
  • increase in peripheral blood mononuclear cells lacking T and B cells markers is seen by 2 months of age and bemose more severe with age   (MGI Ref ID J:7308)
  • at 8 months of age a 16-fold increase in monocytes is seen in males compared to females   (MGI Ref ID J:7308)
• increased plasma cell number
  • increase in the frequency and absolute numbers of Ig-bearing cells associated with advanced autoimmune disease is seen in males but not females   (MGI Ref ID J:108760)
  • frequency of Ig-bearing cells is increased in the thymus   (MGI Ref ID J:108760)
• increased spleen weight
  • 4-fold increase in spleen weight   (MGI Ref ID J:6235)
• renal/urinary system phenotype
• glomerulonephritis
  • acute to subacute exudative and proliferative glomerulonephritis   (MGI Ref ID J:6235)
• increased urine protein level
  • seen at 4 months of age   (MGI Ref ID J:7308)
• homeostasis/metabolism phenotype
• increased urine protein level
  • seen at 4 months of age   (MGI Ref ID J:7308)
• cellular phenotype
• abnormal B cell differentiation
  • frequency of C3d receptor bearing cells is increased in young mice but declines with age   (MGI Ref ID J:108760)

X/Yaa

        BXSB/MpJScr

• mortality/aging
• premature death   (MGI Ref ID J:10973)
• immune system phenotype
• decreased CD4-positive T cell number
  • pronounced decrease in CD4+ T cells with age   (MGI Ref ID J:10973)
• glomerulonephritis
  • develop severe proliferative glomerulonephritis by 3 to 5 months of age   (MGI Ref ID J:10973)
• increased IgG level   (MGI Ref ID J:10973)
• increased anti-nuclear antigen antibody level
  • anti-nuclear antibody levels are elevated at 3 to 5 months of age   (MGI Ref ID J:10973)
• increased monocyte cell number
  • monocytosis   (MGI Ref ID J:10973)
• increased susceptibility to autoimmune disorder
  • accelerated autoimmune syndrome   (MGI Ref ID J:10973)
• hematopoietic system phenotype
• decreased CD4-positive T cell number
  • pronounced decrease in CD4+ T cells with age   (MGI Ref ID J:10973)
• increased monocyte cell number
  • monocytosis   (MGI Ref ID J:10973)
• renal/urinary system phenotype
• glomerulonephritis
  • develop severe proliferative glomerulonephritis by 3 to 5 months of age   (MGI Ref ID J:10973)

Yaa/Yaa

        BXSB/MpJ

• immune system phenotype
• increased IgG1 level   (MGI Ref ID J:93740)
• increased IgG3 level   (MGI Ref ID J:93740)
• increased circulating interleukin-21 level   (MGI Ref ID J:93740)
• homeostasis/metabolism phenotype
• increased circulating interleukin-21 level   (MGI Ref ID J:93740)

The following phenotype information may relate to a genetic background differing from this JAX^® Mice strain.

X/Yaa

        (SJL/J x BXSB)F1

• mortality/aging
• premature death
  • mean longevity for males is 308 +/- 26 days while only 8 of 16 reciprocal hybrid males died between 270 and 684 days   (MGI Ref ID J:6235)
• immune system phenotype
• enlarged lymph nodes
  • moderately enlarged   (MGI Ref ID J:6235)
  • at 18 to 25 weeks the combined weight of the axillary, mesenteric, and renal lymph nodes is increased 5-fold compared to C57BL/6J males   (MGI Ref ID J:6235)
• increased susceptibility to autoimmune disorder
  • accelerated autoimmune syndrome relative to reciprocal hybrid males   (MGI Ref ID J:6235)

X/Yaa

        (C57BL/6J x BXSB)F1

• mortality/aging
• premature death
  • mean longevity for males is 332 +/- 14 days compared to 716 +/- 28 days for littermate females   (MGI Ref ID J:6235)
• immune system phenotype
• enlarged lymph nodes
  • moderately enlarged   (MGI Ref ID J:6235)
  • at 18 to 25 weeks the combined weight of the axillary, mesenteric, and renal lymph nodes is increased 5-fold compared to C57BL/6J males   (MGI Ref ID J:6235)
• increased susceptibility to autoimmune disorder
  • accelerated autoimmune syndrome relative to reciprocal hybrid males   (MGI Ref ID J:6235)

X/Yaa

        (NZB x C57BL/6-Yaa)F1

• immune system phenotype
• increased monocyte cell number
  • CD11b⁺ monocyte numbers increase as mice age with a 3-fold increase by 10 months of age   (MGI Ref ID J:129409)
• hematopoietic system phenotype
• increased monocyte cell number
  • CD11b⁺ monocyte numbers increase as mice age with a 3-fold increase by 10 months of age   (MGI Ref ID J:129409)

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Yaa related

Immunology, Inflammation and Autoimmunity Research
Autoimmunity
      lupus erythematosus

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol		Yaa
Allele Name		accelerated autoimmunity and lymphoproliferation
Allele Type		Spontaneous
Common Name(s)		Tp(X;Y)1Ekw;
Strain of Origin		SB/Le
Gene Symbol and Name		Yaa, accelerated autoimmunity and lymphoproliferation transposition
Chromosome		Y
Gene Common Name(s)		Tp(X;Y)1Ekw;
General Note		In congenic C57BL/6 Yaa mice expression of Tlr7 is increased 2-fold.
Molecular Note		A region of the X chromosome that includes Tlr7 and Prps2 is translocated to the Y chromosome. [MGI Ref ID J:111064] [MGI Ref ID J:140028]

Genotyping

Genotyping Information

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Baccala R; Gonzalez-Quintial R; Schreiber RD; Lawson BR; Kono DH; Theofilopoulos AN. 2012. Anti-IFN-alpha/beta Receptor Antibody Treatment Ameliorates Disease in Lupus-Predisposed Mice. J Immunol 189(12):5976-84. [PubMed: 23175700]  [MGI Ref ID J:190844]

Bubier JA; Sproule TJ; Foreman O; Spolski R; Shaffer DJ; Morse HC 3rd; Leonard WJ; Roopenian DC. 2009. A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice. Proc Natl Acad Sci U S A 106(5):1518-23. [PubMed: 19164519]  [MGI Ref ID J:144484]

McPhee CG; Sproule TJ; Shin DM; Bubier JA; Schott WH; Steinbuck MP; Avenesyan L; Morse HC 3rd; Roopenian DC. 2011. MHC class I family proteins retard systemic lupus erythematosus autoimmunity and B cell lymphomagenesis. J Immunol 187(9):4695-704. [PubMed: 21964024]  [MGI Ref ID J:179430]

Additional References

Andrews BS; Eisenberg RA; Theofilopoulos AN; Izui S; Wilson CB; McConahey PJ; Murphy ED; Roths JB; Dixon FJ. 1978. Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains. J Exp Med 148(5):1198-215. [PubMed: 309911]  [MGI Ref ID J:27634]

Eisenberg RA; Izui S; McConahey PJ; Hang L; Peters CJ; Theofilopoulos AN; Dixon FJ. 1980. Male determined accelerated autoimmune disease in BXSB mice: transfer by bone marrow and spleen cells. J Immunol 125(3):1032-6. [PubMed: 7410826]  [MGI Ref ID J:6372]

Gilbert D; Lopez B; Parain J; Koutouzov S; Tron F. 2000. Overlap of the anti-cardiolipin and anti-nucleosome responses of the (NZW X BXSB)F1 mouse strain: a new pattern of cross-reactivity for lupus-related autoantibodies Eur J Immunol 30(11):3271-80. [PubMed: 11093143]  [MGI Ref ID J:65821]

Luzina IG; Atamas SP; Storrer CE; daSilva LC; Kelsoe G; Papadimitriou JC; Handwerger BS. 2001. Spontaneous formation of germinal centers in autoimmune mice. J Leukoc Biol 70(4):578-84. [PubMed: 11590194]  [MGI Ref ID J:72513]

Murphy ED; Roths JB. 1979. A Y chromosome associated factor in strain BXSB producing accelerated autoimmunity and lymphoproliferation. Arthritis Rheum 22(11):1188-94. [PubMed: 315777]  [MGI Ref ID J:6235]

Yaa related

Anders HJ; Krug A; Pawar RD. 2008. Molecular mimicry in innate immunity? The viral RNA recognition receptor TLR7 accelerates murine lupus. Eur J Immunol 38(7):1795-9. [PubMed: 18581336]  [MGI Ref ID J:137453]

Arabo A; Costa O; Tron F; Caston J. 2005. Spatial and motor abilities during the course of autoimmune disease in (NZW x BXSB)F1 lupus-prone mice. Behav Brain Res 165(1):126-37. [PubMed: 16168499]  [MGI Ref ID J:115747]

Boehm GW; Sherman GF; Hoplight BJ 2nd; Hyde LA; Bradway DM; Galaburda AM; Ahmed SA; Denenberg VH. 1998. Learning in year-old female autoimmune BXSB mice. Physiol Behav 64(1):75-82. [PubMed: 9661985]  [MGI Ref ID J:49007]

Boross P; Arandhara VL; Martin-Ramirez J; Santiago-Raber ML; Carlucci F; Flierman R; van der Kaa J; Breukel C; Claassens JW; Camps M; Lubberts E; Salvatori D; Rastaldi MP; Ossendorp F; Daha MR; Cook HT; Izui S; Botto M; Verbeek JS. 2011. The inhibiting Fc receptor for IgG, FcgammaRIIB, is a modifier of autoimmune susceptibility. J Immunol 187(3):1304-13. [PubMed: 21724994]  [MGI Ref ID J:179175]

Deane JA; Pisitkun P; Barrett RS; Feigenbaum L; Town T; Ward JM; Flavell RA; Bolland S. 2007. Control of Toll-like Receptor 7 Expression Is Essential to Restrict Autoimmunity and Dendritic Cell Proliferation. Immunity 27(5):801-10. [PubMed: 17997333]  [MGI Ref ID J:127600]

Denenberg VH; Hoplight B; Sherman GF; Mobraaten LE. 2001. Effects of the uterine environment and neocortical ectopias upon behavior of BXSB-Yaa+mice. Dev Psychobiol 38(3):154-63. [PubMed: 11279592]  [MGI Ref ID J:72331]

Denenberg VH; Sherman G; Schrott LM; Waters NS; Boehm GW; Galaburda AM; Mobraaten LE. 1996. Effects of embryo transfer and cortical ectopias upon the behavior of BXSB-Yaa and BXSB-Yaa + mice. Brain Res Dev Brain Res 93(1-2):100-8. [PubMed: 8804696]  [MGI Ref ID J:33655]

Eisenberg RA; Izui S; McConahey PJ; Hang L; Peters CJ; Theofilopoulos AN; Dixon FJ. 1980. Male determined accelerated autoimmune disease in BXSB mice: transfer by bone marrow and spleen cells. J Immunol 125(3):1032-6. [PubMed: 7410826]  [MGI Ref ID J:6372]

Fairhurst AM; Hwang SH; Wang A; Tian XH; Boudreaux C; Zhou XJ; Casco J; Li QZ; Connolly JE; Wakeland EK. 2008. Yaa autoimmune phenotypes are conferred by overexpression of TLR7. Eur J Immunol 38(7):1971-8. [PubMed: 18521959]  [MGI Ref ID J:137309]

Fossati L; Iwamoto M; Merino R; Izui S. 1995. Selective enhancing effect of the Yaa gene on immune responses against self and foreign antigens. Eur J Immunol 25(1):166-73. [PubMed: 7843228]  [MGI Ref ID J:22499]

Fossati L; Sobel ES; Iwamoto M; Cohen PL; Eisenberg RA; Izui S. 1995. The Yaa gene-mediated acceleration of murine lupus: Yaa- T cells from non-autoimmune mice collaborate with Yaa+ B cells to produce lupus autoantibodies in vivo. Eur J Immunol 25(12):3412-7. [PubMed: 8566031]  [MGI Ref ID J:31227]

Hang LM; Izui S; Dixon FJ. 1981. (NZW x BXSB)F1 hybrid. A model of acute lupus and coronary vascular disease with myocardial infarction. J Exp Med 154(1):216-21. [PubMed: 7252427]  [MGI Ref ID J:38157]

Hudgins CC; Steinberg RT; Klinman DM; Reeves MJ; Steinberg AD. 1985. Studies of consomic mice bearing the Y chromosome of the BXSB mouse. J Immunol 134(6):3849-54. [PubMed: 3989299]  [MGI Ref ID J:7823]

Hugin AW; Fossati-Jimack L; Izui S. 2000. The autoimmune accelerating yaa mutation does not accelerate murine AIDS. Cell Immunol 200(2):76-80. [PubMed: 10753498]  [MGI Ref ID J:114277]

Hyde LA; Stavnezer AJ; Bimonte HA; Sherman GF; Denenberg VH. 2002. Spatial and nonspatial Morris maze learning: impaired behavioral flexibility in mice with ectopias located in the prefrontal cortex. Behav Brain Res 133(2):247-59. [PubMed: 12110458]  [MGI Ref ID J:108472]

Izui S; Masuda K; Yoshida H. 1984. Acute SLE in F1 hybrids between SB/Le and NZW mice; prominently enhanced formation of gp70 immune complexes by a Y chromosome-associated factor from SB/Le mice. J Immunol 132(2):701-4. [PubMed: 6690614]  [MGI Ref ID J:7276]

Izui S; Merino R; Fossati L; Iwamoto M. 1994. The role of the Yaa gene in lupus syndrome. Int Rev Immunol 11(3):211-30. [PubMed: 7930846]  [MGI Ref ID J:21990]

Jansson L; Holmdahl R. 1994. The Y chromosome-linked autoimmune accelerating yaa gene suppresses collagen-induced arthritis. Eur J Immunol 24(5):1213-7. [PubMed: 8181531]  [MGI Ref ID J:18810]

Kamada H; Takaoka Y; Kitagaki K; Nagai H. 1995. Effect of cyclophosphamide on lymphokine production in MRL/lpr.Yaa mice. Inflamm Res 44(11):491-8. [PubMed: 8597884]  [MGI Ref ID J:30518]

Kawano H; Abe M; Zhang D; Saikawa T; Fujimori M; Hirose S; Shirai T. 1992. Heterozygosity of the major histocompatibility complex controls the autoimmune disease in (NZW x BXSB) F1 mice. Clin Immunol Immunopathol 65(3):308-14. [PubMed: 1451334]  [MGI Ref ID J:3381]

Khaled AR; Butfiloski EJ; Villas B; Sobel ES; Schiffenbauer J. 1999. Aberrant expression of the NF-kappaB and IkappaB proteins in B cells from viable motheaten mice. Autoimmunity 30(2):115-28. [PubMed: 10435725]  [MGI Ref ID J:117314]

Kikuchi S; Amano H; Amano E; Fossati-Jimack L; Santiago-Raber ML; Moll T; Ida A; Kotzin BL; Izui S. 2005. Identification of 2 major loci linked to autoimmune hemolytic anemia in NZB mice. Blood 106(4):1323-9. [PubMed: 15860660]  [MGI Ref ID J:117292]

Kikuchi S; Fossati-Jimack L; Moll T; Amano H; Amano E; Ida A; Ibnou-Zekri N; Laporte C; Santiago-Raber ML; Rozzo SJ; Kotzin BL; Izui S. 2005. Differential role of three major New Zealand black-derived loci linked with Yaa-induced murine lupus nephritis. J Immunol 174(2):1111-7. [PubMed: 15634937]  [MGI Ref ID J:95829]

Kikuchi S; Santiago-Raber ML; Amano H; Amano E; Fossati-Jimack L; Moll T; Kotzin BL; Izui S. 2006. Contribution of NZB autoimmunity 2 to Y-linked autoimmune acceleration-induced monocytosis in association with murine systemic lupus. J Immunol 176(5):3240-7. [PubMed: 16493085]  [MGI Ref ID J:129409]

Kim HJ; Wang X; Radfar S; Sproule TJ; Roopenian DC; Cantor H. 2011. CD8+ T regulatory cells express the Ly49 Class I MHC receptor and are defective in autoimmune prone B6-Yaa mice. Proc Natl Acad Sci U S A 108(5):2010-5. [PubMed: 21233417]  [MGI Ref ID J:169125]

Kofler R; McConahey PJ; Duchosal MA; Balderas RS; Theofilopoulos AN; Dixon FJ. 1991. An autosomal recessive gene that delays expression of lupus in BXSB mice. J Immunol 146(4):1375-9. [PubMed: 1991974]  [MGI Ref ID J:10973]

Kono DH; Balomenos D; Park MS; Theofilopoulos AN. 2000. Development of lupus in BXSB mice is independent of IL-4. J Immunol 164(1):38-42. [PubMed: 10604990]  [MGI Ref ID J:112421]

Kuroki A; Moll T; Lopez-Hoyos M; Fossati-Jimack L; Ibnou-Zekri N; Kikuchi S; Merino J; Merino R; Izui S. 2004. Enforced Bcl-2 expression in B lymphocytes induces rheumatoid factor and anti-DNA production, but the Yaa mutation promotes only anti-DNA production. Eur J Immunol 34(4):1077-84. [PubMed: 15048718]  [MGI Ref ID J:88856]

Leiter EH; Prochazka M; Shultz LD. 1987. Effect of immunodeficiency on diabetogenesis in genetically diabetic (db/db) mice. J Immunol 138(10):3224-9. [PubMed: 3553324]  [MGI Ref ID J:32752]

Lin Q; Xiu Y; Jiang Y; Tsurui H; Nakamura K; Kodera S; Ohtsuji M; Ohtsuji N; Shiroiwa W; Tsukamoto K; Amano H; Amano E; Kinoshita K; Sudo K; Nishimura H; Izui S; Shirai T; Hirose S. 2006. Genetic dissection of the effects of stimulatory and inhibitory IgG Fc receptors on murine lupus. J Immunol 177(3):1646-54. [PubMed: 16849473]  [MGI Ref ID J:137977]

Maeda K; Malykhin A; Teague-Weber BN; Sun XH; Farris AD; Coggeshall KM. 2009. Interleukin-6 aborts lymphopoiesis and elevates production of myeloid cells in systemic lupus erythematosus-prone B6.Sle1.Yaa animals. Blood 113(19):4534-40. [PubMed: 19224760]  [MGI Ref ID J:148718]

Merino R; Fossati L; Lacour M; Lemoine R; Higaki M; Izui S. 1992. H-2-linked control of the Yaa gene-induced acceleration of lupus-like autoimmune disease in BXSB mice. Eur J Immunol 22(2):295-9. [PubMed: 1537372]  [MGI Ref ID J:2011]

Merino R; Iwamoto M; Gershwin ME; Izui S. 1994. The Yaa gene abrogates the major histocompatibility complex association of murine lupus in (NZB x BXSB)F1 hybrid mice. J Clin Invest 94(2):521-5. [PubMed: 8040305]  [MGI Ref ID J:19547]

Merino R; Shibata T; De Kossodo S; Izui S. 1989. Differential effect of the autoimmune Yaa and lpr genes on the acceleration of lupus-like syndrome in MRL/MpJ mice. Eur J Immunol 19(11):2131-7. [PubMed: 2599002]  [MGI Ref ID J:108759]

Moll T; Martinez-Soria E; Santiago-Raber ML; Amano H; Pihlgren-Bosch M; Marinkovic D; Izui S. 2005. Differential activation of anti-erythrocyte and anti-DNA autoreactive B lymphocytes by the Yaa mutation. J Immunol 174(2):702-9. [PubMed: 15634889]  [MGI Ref ID J:132847]

Morel L; Croker BP; Blenman KR; Mohan C; Huang G; Gilkeson G; Wakeland EK. 2000. Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains. Proc Natl Acad Sci U S A 97(12):6670-5. [PubMed: 10841565]  [MGI Ref ID J:62719]

Murphy ED; Roths JB. 1979. A Y chromosome associated factor in strain BXSB producing accelerated autoimmunity and lymphoproliferation. Arthritis Rheum 22(11):1188-94. [PubMed: 315777]  [MGI Ref ID J:6235]

Ozaki K; Spolski R; Ettinger R; Kim HP; Wang G; Qi CF; Hwu P; Shaffer DJ; Akilesh S; Roopenian DC; Morse HC 3rd; Lipsky PE; Leonard WJ. 2004. Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6. J Immunol 173(9):5361-71. [PubMed: 15494482]  [MGI Ref ID J:93740]

Pisetsky DS; Klatt C; Dawson D; Roths JB. 1985. The influence of Yaa on anti-DNA responses of B6-lpr mice. Clin Immunol Immunopathol 37(3):369-76. [PubMed: 3931946]  [MGI Ref ID J:109825]

Rankin J; Boyle JJ; Rose SJ; Gabriel L; Lewis M; Thiruudaian V; Rogers NJ; Izui S; Morley BJ. 2007. The Bxs6 locus of BXSB mice is sufficient for high-level expression of gp70 and the production of gp70 immune complexes. J Immunol 178(7):4395-401. [PubMed: 17371996]  [MGI Ref ID J:145049]

Rosenblatt N; Hartmann KU; Loor F. 1994. The Yaa gene-dependent B-cell deficiency worsens the generalized lymphadenopathy and autoimmunity of C57BL/6-gld male mice. Immunology 83(3):476-83. [PubMed: 7835973]  [MGI Ref ID J:21189]

Rosenblatt N; Hartmann KU; Loor F. 1994. The Yaa mutation induces the development of autoimmunity in mice heterozygous for the gld (generalized lymphadenopathy disease) mutation. Cell Immunol 156(2):519-28. [PubMed: 8025960]  [MGI Ref ID J:19169]

Santiago ML; Fossati L; Jacquet C; Muller W; Izui S; Reininger L. 1997. Interleukin-4 protects against a genetically linked lupus-like autoimmune syndrome. J Exp Med 185(1):65-70. [PubMed: 8996242]  [MGI Ref ID J:37574]

Santiago ML; Mary C; Parzy D; Jacquet C; Montagutelli X; Parkhouse RM; Lemoine R; Izui S; Reininger L. 1998. Linkage of a major quantitative trait locus to Yaa gene-induced lupus-like nephritis in (NZW x C57BL/6)F1 mice. Eur J Immunol 28(12):4257-67. [PubMed: 9862363]  [MGI Ref ID J:52110]

Santiago-Raber ML; Kikuchi S; Borel P; Uematsu S; Akira S; Kotzin BL; Izui S. 2008. Evidence for genes in addition to Tlr7 in the Yaa translocation linked with acceleration of systemic lupus erythematosus. J Immunol 181(2):1556-62. [PubMed: 18606711]  [MGI Ref ID J:137656]

Schrott LM; Waters NS; Boehm GW; Sherman GF; Morrison L; Rosen GD; Behan PO; Galaburda AM; Denenberg VH. 1993. Behavior, cortical ectopias, and autoimmunity in BXSB-Yaa and BXSB-Yaa+ mice. Brain Behav Immun 7(3):205-23. [PubMed: 8147964]  [MGI Ref ID J:14455]

Shimizu M; Sekine K; Matsuzawa A; Iwaguchi T. 1992. Cell electrophoretic characterization of abnormally expanded lymphocytes in autoimmune lprcg, lpr, gld and Yaa mice, and of thymocyte subsets. Electrophoresis 13(3):136-42. [PubMed: 1592043]  [MGI Ref ID J:2361]

Smith HR; Chused TM; Steinberg AD. 1983. The effect of the X-linked immune deficiency gene (xid) upon the Y chromosome-related disease of BXSB mice. J Immunol 131(3):1257-62. [PubMed: 6886419]  [MGI Ref ID J:7172]

Subramanian S; Tus K; Li QZ; Wang A; Tian XH; Zhou J; Liang C; Bartov G; McDaniel LD; Zhou XJ; Schultz RA; Wakeland EK. 2006. A Tlr7 translocation accelerates systemic autoimmunity in murine lupus. Proc Natl Acad Sci U S A 103(26):9970-5. [PubMed: 16777955]  [MGI Ref ID J:111064]

Suzuki H; Yasukawa K; Saito T; Narazaki M; Hasegawa A; Taga T; Kishimoto T. 1993. Serum soluble interleukin-6 receptor in MRL/lpr mice is elevated with age and mediates the interleukin-6 signal. Eur J Immunol 23(5):1078-82. [PubMed: 8477802]  [MGI Ref ID J:4970]

Taguchi N; Hashimoto Y; Naiki M; Farr AG; Boyd RL; Ansari AA; Shultz LD; Kotzin BL; Dorshkind K; Ikehara S; Gershwin ME. 1999. Abnormal thymic expression of epithelial cell adhesion molecule (EP-CAM) in New Zealand Black (NZB) mice. J Autoimmun 13(4):393-404. [PubMed: 10585755]  [MGI Ref ID J:59174]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX11

Colony Maintenance

Breeding & Husbandry	This is an inbred strain. Males carry the BXSB-derived Yaa mutation on the Y chromosome. To maintain the live inbred colony, unaffected females (+/+) may be bred with affected males (Yaa/Y).
Mating System	+/+ sibling x Hemizygote         (Female x Male)   01-MAR-06
Diet Information	LabDiet® 5K54

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

General Supply Notes

• View the complete collection of spontaneous mutants in the Mouse Mutant Resource.
• Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

	Control
	Female from the colony
	See control note:	The most suitable control animals are sex-matched, autoimmune disease-resistant BXSB.B6-Yaa+ consomic males carrying the C57BL/6-derived Y chromosome in place of the BXSB-derived mutant Yaa-containing Y chromosome. BXSB.B6-Yaa+ consomic mice are available with different amounts of backcrossing to BXSB/MpJ inbred females: --Stock No. 021330 are backcrossed at least 40 generations, --Stock No. 001925 are backcrossed at least 22 generations, and --Stock No. 000742 are backcrossed at least 10 generations.
	000742 BXSB.B6-Yaa+/J
	001925 BXSB.B6-Yaa+/MobJ
Considerations for Choosing Controls
Control Pricing Information for Genetically Engineered Mutant Strains.

Important Note

Males of this strain carry the BXSB-derived Yaa mutation on the Y chromosome.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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phone:	207-288-6470
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JAX^® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

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The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.