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Strain Name:

C57BL/6J-Hbbp Hrrh-7J/J

Stock Number:

000758

Availability:

Repository-Cryopreserved

Price and Supply Information

General Terms and Conditions

Former Name      C57BL/6J-Hbbp hrrh-7J/J    (Changed: 15-DEC-04 )
Genes & Alleles   Hbb;   Hbbp;   Hr;   Hrrh-7J;

Product Information

Strain Details

Type JAX® GEMM® Strain - Mutant Strain
Additional information on JAX® GEMM® Strains.
Type JAX® GEMM® Strain - Spontaneous Mutation
Specieslaboratory mouse
GenerationN7+N1

Strain Description
Rhino mice have spleen cells with a defective response to T-dependent antigens and they develop an autoimmune disease characterized by hypergammaglobulinemia, immunoglobulin deposits in basement membrane of skin, spleen, liver, and kidney, and presence of antinuclear antibodies which occur in young mice and increase with age. These mice have increased numbers of Thy1 positive epidermal dendritic cells. Like homozygous hairless mice, rhino mice are hairless by 5 weeks and their skin becomes wrinkled and thickened.

Gene & Allele Details

Allele Symbol Hbbp
Allele Name p
Strain of OriginAU
Gene Symbol and Name Hbb, hemoglobin beta chain complex
Chromosome 7
Gene Common Name(s) CD113t-C; HBD;
 
Allele Symbol Hrrh-7J
Allele Name rhino 7 Jackson
Strain of OriginC57BL/6J-Hbbp
Gene Symbol and Name Hr, hairless
Chromosome 14
Gene Common Name(s) ALUNC; AU; HSA277165; N; ba; baldy; bldy; rh; rh-bmh; rhino-bald Mill Hill;

Related Strains

View Strains carrying other alleles of Hbb     (11 strains)

Strains carrying other alleles of Hr
007621   B6.129S6-Hrtm1Cct/J
001737   B6.A-H2-T18a.HRS-Hrhr/J
007622   B6;SJL-Tg(KRT14-Hr)551Cct/J
002922   D2.HRS-Hrhr/J
000673   HRS/J
001103   HRS/J-Hrhr Esdb/+ Esdb/J
000266   RHJ/Le
001591   RHJ/LeJ
002335   SKH2/J
000147   WLHR/LeJ
View Strains carrying other alleles of Hr     (10 strains)

Additional Web Information

JAX® NOTES, January 1989; 436. Phenotypic abnormalities in hr-locus mutants.
JAX® NOTES, January 1989; 436. References for the Rhino Allele.
JAX® NOTES, October 1988; 435. Introduction of Rhino (hrrh) into Jackson Laboratory Production Colonies.

Research Applications

This mouse can be used to support research in many areas including:

Hrrh-7J related

Immunology and Inflammation Research
Immunodeficiency Associated with Other Defects

References

Additional References

Price and Supply Information

Strain Name: C57BL/6J-Hbbp Hrrh-7J/J
Stock Number: 000758

Price Details

IMPORTANT NOTE: Prices are based on shipping destination. The shipping destinations are:

*Pricing for Shipping Destination selected:

        USA, Canada and Mexico

Price(s) in US dollars ($)
Cryorecovery Fee $1900.00

Supply Details

Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes Cryorecovery - Standard.
The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.

Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 or 1-207-288-5845.
Genomic DNA is available for this strain from the Mouse DNA Resource.

LicensingSee General Terms and Conditions below  

General Terms and Conditions

View JAX® Mice & Services Conditions of Use.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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