Strain Name:

AKXD9/TyJ

Stock Number:

000763

Availability:

Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names AKXD-9/TyJ    (Changed: 15-DEC-04 )
Type Recombinant Inbred (RI);
Additional information on Recombinant Inbred Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse
RI progenitor AKR/J DBA/2J
H2 Haplotyped
GenerationF30p

Appearance
albino
Related Genotype: Tyrc/Tyrc

Related Strains

AKXD Strains
001005   AKXD1/TyJ
001017   AKXD10/TyJ
001003   AKXD11/TyJ
000765   AKXD13/TyJ
000779   AKXD14/TyJ
000954   AKXD15/TyJ
000958   AKXD16/TyJ
001093   AKXD18/TyJ
000776   AKXD2/TyJ
001001   AKXD20/TyJ
001062   AKXD21/TyJ
000947   AKXD22/TyJ
000780   AKXD23/TyJ
000969   AKXD24/TyJ
000949   AKXD25/TyJ
000764   AKXD27/TyJ
000957   AKXD28/TyJ
000959   AKXD3/TyJ
000777   AKXD6/TyJ
View AKXD Strains     (19 strains)

Strains carrying   Rmcfr allele
000690   129P3/J
000765   AKXD13/TyJ
000954   AKXD15/TyJ
001093   AKXD18/TyJ
000947   AKXD22/TyJ
000654   CBA/CaJ
000670   DBA/1J
View Strains carrying   Rmcfr     (7 strains)

Strains carrying   Tyrc allele
001017   AKXD10/TyJ
000765   AKXD13/TyJ
000954   AKXD15/TyJ
000958   AKXD16/TyJ
001093   AKXD18/TyJ
001062   AKXD21/TyJ
000947   AKXD22/TyJ
000969   AKXD24/TyJ
000777   AKXD6/TyJ
000409   B10.129P-H1b Hbbd Tyrc Ea7a/(5M)oSnJ
000418   B10.129P-H1b Tyrc Hbbd/(5M)nSnJ
000432   B10.C-H1b Hbbd Tyrc/(41N)SnJ
000383   B6.C-Tyrc H1b Hbbd/ByJ
001759   STOCK A Tyrc Sha/J
000006   STOCK Hk Tyrc/J
View Strains carrying   Tyrc     (15 strains)

Strains carrying other alleles of Emv13
000779   AKXD14/TyJ
000947   AKXD22/TyJ
000764   AKXD27/TyJ
000777   AKXD6/TyJ
View Strains carrying other alleles of Emv13     (4 strains)

Strains carrying other alleles of Emv14
000765   AKXD13/TyJ
000779   AKXD14/TyJ
001093   AKXD18/TyJ
000780   AKXD23/TyJ
000764   AKXD27/TyJ
000777   AKXD6/TyJ
View Strains carrying other alleles of Emv14     (6 strains)

Strains carrying other alleles of Rmcf
000646   A/J
000648   AKR/J
000779   AKXD14/TyJ
000780   AKXD23/TyJ
000764   AKXD27/TyJ
000777   AKXD6/TyJ
000667   C57BR/cdJ
000668   C57L/J
000669   C58/J
000682   RF/J
000644   SEA/GnJ
000686   SJL/J
000688   ST/bJ
View Strains carrying other alleles of Rmcf     (13 strains)

View Strains carrying other alleles of Tyr     (31 strains)

Phenotype

Phenotype Information

View Phenotypic Data

View Mammalian Phenotype Terms

Mammalian Phenotype Terms
      assigned by genotype

       
  • tumorigenesis
  • histiocytic sarcoma (MGI Ref ID J:69716)
    • 1 of 16 lymphomas assessed
  • lymphoma (MGI Ref ID J:20300)
    • propensity to develop lymphoma with mean age of onset 448 days
    • B cell derived lymphoma (MGI Ref ID J:4179)
      • assessment of 13 lymphomas from 20 female mice shows 54% are B cell derived
      • 2 of 16 assessed lymphomas are pre-B cell lymphoblastic lymphoma
      • small lymphocytic lymphoma (MGI Ref ID J:69716)
        • 1 of 16 lymohomas assessed
      • splenic marginal zone lymphoma (MGI Ref ID J:69716)
        • 3 of 16 lymphomas assessed
    • T cell derived lymphoma (MGI Ref ID J:4179)
      • assessment of 13 lymphomas from 20 female mice shows 38% are T cell derived
      • lymphoblastic lymphoma (MGI Ref ID J:69716)
        • of 16 lymphomas assessed 6 are pre-T cell lymphoblastic lymphomas, 1 is a T cell lymphoblastic lymphoma, and 2 are lymphoblastic lymphomas
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Research Tools
Cancer Research
      genes regulating lymphoma development
Genetics Research
      Gene Mapping: Tools for QTL Mapping, Segregation and Linkage Analysis

Tyrc related

Dermatology Research
Color and White Spotting Defects
      oculocutaneous albinism, type I

Mouse/Human Gene Homologs
albinism, tyrosine negative

Genes & Alleles

Gene & Allele Information

 
Allele Symbol Rmcfr
Allele Name MCF resistant
Allele Type Spontaneous
Strain of Originmultiple strains
Gene Symbol and Name Rmcf, resistance to MCF virus
Chromosome 5
General Note

This locus controls resistance and susceptibility of cells in tissue culture to infection by mink cell focus-forming murine leukemia viruses. The allele Rmcfr determines resistance and occurs in strains DBA/1, DBA/2, and CBA/Ca; the allele Rmcfs determines susceptibility and occurs in strains AKR/J, C57BL/6, BALB/c, CBA/J, NFS, NZB, 129/J, and many others. Heterozygotes are as resistant as the resistant parent or nearly so. Rmcf is different from and independent of Fv1,a locus that controls susceptibility to infection by ecotropic viruses. Rmcf is located on Chr 5 close to Hm near the centromeric end (J:7108). Rmcfr protects (AKR x CBA/Ca)F1 and (AKR x DBA/2)F1 hybrids from development of spontaneous thymic lymphomas and reduces the incidence of MCF-induced thymic lymphomas (J:7175). It also reduces susceptibility of cells of Sxvs/Sxvr mice to exogenous xenotropic viruses (J:7951). In addition, in strains susceptible to Friend virus-induced erythroleukemia, a condition thought to be due to the replication of MCF virus, Rmcfr increases resistance to the virus-induced erythroleukemia. It may cause resistance by coding for or regulating the production of an MCF-related envelope glycoprotein that blocks the receptor for MCF viruses (J:8074). This conclusion is reinforced by the findings of Buller et al. (J:8497), who showed that the Rmcfr allele contains an endogenous MCF gp70 env gene and that theRmcfs allele, at least in some strains (C57BL/6, CBA/J, and A/WySn), contains a xenotropic gp70 env gene. Presumably the MCF gp70 inhibits exogenous MCF infection in vitro by a mechanism of viral interference.

Molecular Note This locus controls resistance of cells to infection by mink cell focus-forming murine leukemia viruses. The dominant r (resistance) allele is found in strains DBA/1, DBA/2 and CBA/Ca.
 
Allele Symbol Tyrc
Allele Name albino
Allele Type Spontaneous
Common Name(s) c;
Strain of Originold mutant of the mouse fancy
Gene Symbol and Name Tyr, tyrosinase
Chromosome 7
Gene Common Name(s) C; OCA1A; OCAIA; SHEP3; albino; c; skc35; skin/coat color 35;
General Note Tyrc, albino. This very old mutant was already known in Greek and Roman times. Hair and eyes are completely devoid of pigment (J:5436, J:5001, J:30725). The albino mutation affects the amount of tyrosinase, and thus of melanin, in pigment cells, but does not interfere with the production of pigment cells themselves (J:12173, J:13092). Melanocytes with melanosomes showing normal fine structure occur in the retina and hair follicles. Pigment granules are smaller and fewer than normal and completely lack melanin (J:5346, J:5001, J:30725). Tyrosinase is almost absent (J:12173).Although Tyr is the structural gene for tyrosinase, some albino mutations may affect tyrosinase enzyme regulation rather than structure (J:6611), suggesting that these mutations affect tyrosinase inhibition (J:5346), presumably via control regions of the gene. All the mutant alleles are recessive to wild-type in phenotype, but heterozygotes with wild-type produce intermediate amounts of tyrosinase (J:12173).Albino-locus mutants with lightly pigmented eyes have a reduced number of fibers of the optic nerve going to the ipsilateral lateral geniculate nucleus of the brain. This is probably a secondary effect of reduced tyrosinase activity or amount of pigment in the pigmentepithelium, since genes at other loci that reduce eye pigmentation also cause the same anomaly (J:5436, J:6064).Abnormal retinal pathways disrupted at the optic chiasm that occur in albinism can be corrected with a Tyr normal transgene (J:22320).Lipofuscin is a terminal oxidation product pigment that accumulates with age. In a cross of C57BL/6J and BALB/cJ, which differ in cardiac deposition of the pigment, this trait segregated with albinism, and is controlled by the Tyr locus (J:15460).Tyrc homozygotes do not perform as well as normal in a number of behavioral tests. It is likely that this effect is mediated, at least in part, by defective vision resulting from lack of retinal pigment (J:5470, J:5360, J:5378).
Molecular Note The specific mutation in the albino allele is a G to C transversion causing an amino acid change from cysteine to serine. This mutation introduces a DdeI enzyme restriction site. [MGI Ref ID J:10889] [MGI Ref ID J:40223]
 
Gene Symbol and Name Emv13, endogenous ecotropic MuLV 13
Chromosome 2
Gene Common Name(s) AKR leukemia virus inducer 3; AKR leukemia virus protein inducer; Akv-3; Akvp; Emv-13;
 
Gene Symbol and Name Emv14, endogenous ecotropic MuLV 14
Chromosome 11
Gene Common Name(s) AKR leukemia virus inducer 4; Akv-2J; Akv-4; Emv-14;

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Genotyping resources and troubleshooting

References

References

Selected Reference(s)

Mucenski ML; Taylor BA; Jenkins NA; Copeland NG. 1986. AKXD recombinant inbred strains: models for studying the molecular genetic basis of murine lymphomas. Mol Cell Biol 6(12):4236-43. [PubMed: 3025647]  [MGI Ref ID J:20300]

Additional References

Jenkins NA; Copeland NG; Taylor BA; Lee BK. 1981. Dilute (d) coat colour mutation of DBA/2J mice is associated with the site of integration of an ecotropic MuLV genome. Nature 293(5831):370-4. [PubMed: 6268990]  [MGI Ref ID J:6587]

Rmcfr related

Buller RS; Ahmed A; Portis JL. 1987. Identification of two forms of an endogenous murine retroviral env gene linked to the Rmcf locus. J Virol 61(1):29-34. [PubMed: 3023705]  [MGI Ref ID J:8497]

Buller RS; Sitbon M; Portis JL. 1988. The endogenous mink cell focus-forming (MCF) gp70 linked to the Rmcf gene restricts MCF virus replication in vivo and provides partial resistance to erythroleukemia induced by Friend murine leukemia virus. J Exp Med 167(5):1535-46. [PubMed: 2835418]  [MGI Ref ID J:27618]

Frankel WN; Stoye JP; Taylor BA; Coffin JM. 1989. Genetic identification of endogenous polytropic proviruses by using recombinant inbred mice. J Virol 63(9):3810-21. [PubMed: 2547997]  [MGI Ref ID J:9925]

Hartley JW; Yetter RA; Morse HC 3d. 1983. A mouse gene on chromosome 5 that restricts infectivity of mink cell focus-forming recombinant murine leukemia viruses. J Exp Med 158(1):16-24. [PubMed: 6306133]  [MGI Ref ID J:7108]

Jung YT; Lyu MS; Buckler-White A; Kozak CA. 2002. Characterization of a polytropic murine leukemia virus proviral sequence associated with the virus resistance gene Rmcf of DBA/2 mice. J Virol 76(16):8218-24. [PubMed: 12134027]  [MGI Ref ID J:78083]

Kozak CA. 1985. Susceptibility of wild mouse cells to exogenous infection with xenotropic leukemia viruses: control by a single dominant locus on chromosome 1. J Virol 55(3):690-5. [PubMed: 2991590]  [MGI Ref ID J:7951]

Rowe WP; Hartley JW. 1983. Genes affecting mink cell focus-inducing (MCF) murine leukemia virus infection and spontaneous lymphoma in AKR F1 hybrids. J Exp Med 158(2):353-64. [PubMed: 6224881]  [MGI Ref ID J:7175]

Tyrc related

Bharti K; Liu W; Csermely T; Bertuzzi S; Arnheiter H. 2008. Alternative promoter use in eye development: the complex role and regulation of the transcription factor MITF. Development 135(6):1169-78. [PubMed: 18272592]  [MGI Ref ID J:132153]

Chen J; Reifsnyder PC; Scheuplein F; Schott WH; Mileikovsky M; Soodeen-Karamath S; Nagy A; Dosch MH; Ellis J; Koch-Nolte F; Leiter EH. 2005. 'Agouti NOD': identification of a CBA-derived Idd locus on Chromosome 7 and its use for chimera production with NOD embryonic stem cells. Mamm Genome 16(10):775-83. [PubMed: 16261419]  [MGI Ref ID J:102639]

Coleman DL. 1962. Effect of genic substitution on the incorporation of tyrosine into the melanin of mouse skin. Arch Biochem Biophys 96:562-8. [PubMed: 13880466]  [MGI Ref ID J:12173]

Detlefsen JA. 1921. A new mutation in the house mouse Am Naturalist 55:469-73.  [MGI Ref ID J:34484]

Dickie MM. 1966. Platinum Mouse News Lett 34:30.  [MGI Ref ID J:13442]

Guillery RW. 1974. Visual pathways in albinos. Sci Am 230(5):44-54. [PubMed: 4822986]  [MGI Ref ID J:5436]

Hearing VJ; Phillips P; Lutzner MA. 1973. The fine structure of melanogenesis in coat color mutants of the mouse. J Ultrastruct Res 43(1):88-106. [PubMed: 4634048]  [MGI Ref ID J:5346]

Hegmann JP; Kieso RA; Hartman HB. 1974. Gene differences influencing visual system function and behavior. Behav Genet 4(2):165-70. [PubMed: 4842093]  [MGI Ref ID J:5470]

Jackson IJ; Bennett DC. 1990. Identification of the albino mutation of mouse tyrosinase by analysis of an in vitro revertant. Proc Natl Acad Sci U S A 87(18):7010-4. [PubMed: 2119500]  [MGI Ref ID J:40223]

Jeffery G; Schutz G; Montoliu L. 1994. Correction of abnormal retinal pathways found with albinism by introduction of a functional tyrosinase gene in transgenic mice. Dev Biol 166(2):460-4. [PubMed: 7813769]  [MGI Ref ID J:22320]

Juriloff DM; Harris MJ; Wong V; Miller JE. 1992. Studies of a spontaneous lethal mutation at the albino locus in SELH/Bc mice. Genome 35(2):342-6. [PubMed: 1618394]  [MGI Ref ID J:62]

Karst SY; Ward-Bailey PF; Smith R; Washburn L; Bergstrom D; Johnson KR; Donahue LR; Davisson MT. 2009. Chick Yellow: a new mutation on Chromosome 3 causing eye and coat color phenotypes MGI Direct Data Submission :.  [MGI Ref ID J:149273]

Mouse Genome Informatics (MGI). 2005. Information obtained from the Oak Ridge National Laboratory Mutant Mouse Database (ORNL), Oak Ridge, TN (http://bio.lsd.ornl.gov/mouse/) :.  [MGI Ref ID J:100221]

Moyer FH. 1966. Genetic variations in the fine structure and ontogeny of mouse melanin granules. Am Zool 6(1):43-66. [PubMed: 5902512]  [MGI Ref ID J:5001]

Qiao JH; Welch CL; Xie PZ; Fishbein MC; Lusis AJ. 1993. Involvement of the tyrosinase gene in the deposition of cardiac lipofuscin in mice. Association with aortic fatty streak development. J Clin Invest 92(5):2386-93. [PubMed: 8227355]  [MGI Ref ID J:15460]

Rios M; Habecker B; Sasaoka T; Eisenhofer G; Tian H; Landis S ; Chikaraishi D ; Roffler-Tarlov S. 1999. Catecholamine synthesis is mediated by tyrosinase in the absence of tyrosine hydroxylase. J Neurosci 19(9):3519-26. [PubMed: 10212311]  [MGI Ref ID J:54692]

Russell LB; Hunsicker PR; Cacheiro NL; Rinchik EM. 1992. Genetic, cytogenetic, and molecular analyses of mutations induced by melphalan demonstrate high frequencies of heritable deletions and other rearrangements from exposure of postspermatogonial stages of the mouse. Proc Natl Acad Sci U S A 89(13):6182-6. [PubMed: 1352884]  [MGI Ref ID J:24557]

SILVERS WK. 1958. Origin and identity of clear cells found in hair bulbs of albino mice. Anat Rec 130(2):135-44. [PubMed: 13545569]  [MGI Ref ID J:30725]

Silvers WK. 1956. Pigment cells: occurrence in hair follicles. J Morphol 99:41-55.  [MGI Ref ID J:13092]

Sweet HO. 1987. Acromelanic (c<a>) Mouse News Lett 78:56.  [MGI Ref ID J:14994]

Thiessen DD; Lindzey G; Owen K. 1970. Behavior and allelic variations in enzyme activity and coat color at the C locus of the mouse. Behav Genet 1(3):257-67. [PubMed: 5005683]  [MGI Ref ID J:5360]

Townsend D; Witkop CJ Jr; Mattson J. 1981. Tyrosinase subcellular distribution and kinetic parameters in wild type and C-locus mutant C57BL/6J mice. J Exp Zool 216(1):113-9. [PubMed: 6793688]  [MGI Ref ID J:6611]

Tyler PA. 1970. Coat color differences and runway learning in mice. Behav Genet 1(2):149-55. [PubMed: 5527659]  [MGI Ref ID J:5378]

Wakamatsu K; Hirobe T; Ito S. 2007. High levels of melanin-related metabolites in plasma from pink-eyed dilution mice. Pigment Cell Res 20(3):222-4. [PubMed: 17516930]  [MGI Ref ID J:148667]

Yokoyama T; Silversides DW; Waymire KG; Kwon BS; Takeuchi T; Overbeek PA. 1990. Conserved cysteine to serine mutation in tyrosinase is responsible for the classical albino mutation in laboratory mice. Nucleic Acids Res 18(24):7293-8. [PubMed: 2124349]  [MGI Ref ID J:10889]

Health & husbandry

Health & Colony Maintenance Information

Currently there no information available for this strain. This may be due to the supply level of this strain.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations View International pricing
Price (US dollars $)
Cryorecovery Fee $1900.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Additional Supply Details

Pricing for International shipping destinations View USA Canada and Mexico pricing
Price (US dollars $)
Cryorecovery Fee $2470.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Additional Supply Details

Supply Details

Standard SupplyCryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
Supply Notes
  • Cryorecovery - Standard.
    We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

  • Genomic DNA is available for this strain from the Mouse DNA Resource.

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Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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