Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names AKXD-23/TyJ    (Changed: 15-DEC-04 ) Type Recombinant Inbred (RI); Additional information on Recombinant Inbred Mice. Visit our online Nomenclature tutorial. Species laboratory mouse RI progenitor AKR/J DBA/2J H2 Haplotype d

Appearance
albino
Related Genotype: Tyr^c/Tyr^c

Related Strains

AKXD Strains

001005	AKXD1/TyJ
001017	AKXD10/TyJ
001003	AKXD11/TyJ
000765	AKXD13/TyJ
000779	AKXD14/TyJ
000954	AKXD15/TyJ
000958	AKXD16/TyJ
001093	AKXD18/TyJ
000776	AKXD2/TyJ
001001	AKXD20/TyJ
001062	AKXD21/TyJ
000947	AKXD22/TyJ
000969	AKXD24/TyJ
000949	AKXD25/TyJ
000764	AKXD27/TyJ
000957	AKXD28/TyJ
000959	AKXD3/TyJ
000777	AKXD6/TyJ
000763	AKXD9/TyJ

View AKXD Strains     (19 strains)

Strains carrying   Rmcf^s allele

000646	A/J
000648	AKR/J
000779	AKXD14/TyJ
000764	AKXD27/TyJ
000777	AKXD6/TyJ
000667	C57BR/cdJ
000668	C57L/J
000669	C58/J
000682	RF/J
000644	SEA/GnJ
000686	SJL/J
000688	ST/bJ

View Strains carrying   Rmcf^s     (12 strains)

Strains carrying other alleles of Emv11

000779	AKXD14/TyJ
000954	AKXD15/TyJ
001093	AKXD18/TyJ
000947	AKXD22/TyJ
000959	AKXD3/TyJ
000777	AKXD6/TyJ
001885	NFS.AK-Emv11/J

View Strains carrying other alleles of Emv11     (7 strains)

Strains carrying other alleles of Emv14

000765	AKXD13/TyJ
000779	AKXD14/TyJ
001093	AKXD18/TyJ
000764	AKXD27/TyJ
000777	AKXD6/TyJ
000763	AKXD9/TyJ

View Strains carrying other alleles of Emv14     (6 strains)

Strains carrying other alleles of Rmcf

000690	129P3/J
000765	AKXD13/TyJ
000954	AKXD15/TyJ
001093	AKXD18/TyJ
000947	AKXD22/TyJ
000763	AKXD9/TyJ
000654	CBA/CaJ
000670	DBA/1J

View Strains carrying other alleles of Rmcf     (8 strains)

Phenotype

Phenotype Information

View Phenotypic Data

Phenotypic Data

Mouse Phenome Database
Wellcome Trust Centre for Human Genetics: Mouse Recombinant Inbred Line (RIL) Genotype Data for AKXD RI Line

View Mammalian Phenotype Terms

Mammalian Phenotype Terms

      assigned by genotype

       

• tumorigenesis
• histiocytic sarcoma (MGI Ref ID J:69716)
  • 3 of 12 characterized lymphomas
• lymphoma (MGI Ref ID J:20300)
  • propensity to develop lymphoma with mean age of onset 445 days
  • assessment of 10 lymphomas from 20 female mice shows 70% are myeloid
• B cell derived lymphoma (MGI Ref ID J:4179)
  • assessment of 10 lymphomas from 20 female mice shows 10% are B cell derived
  • 1 of 12 characterized lymphomas
• splenic marginal zone lymphoma (MGI Ref ID J:69716)
  • 5 of 12 characterized lymphomas
• T cell derived lymphoma (MGI Ref ID J:4179)
  • assessment of 10 lymphomas from 20 female mice shows 10% are T cell derived
• lymphoblastic lymphoma (MGI Ref ID J:69716)
  • 2 of 12 characterized lymphomas are lymphoblastic lymphomas with 1 of those being a T cell lymphoblastic lymphoma

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Research Tools
Cancer Research
      genes regulating lymphoma development
Genetics Research
      Gene Mapping: Tools for QTL Mapping, Segregation and Linkage Analysis

Genes & Alleles

Gene & Allele Information

Allele Symbol		Rmcfs
Allele Name		MCF sensitive
Allele Type		Spontaneous
Strain of Origin		multiple strains
Gene Symbol and Name		Rmcf, resistance to MCF virus
Chromosome		5
General Note		This locus controls resistance and susceptibility of cells in tissue culture to infection by mink cell focus-forming murine leukemia viruses. The allele Rmcfr determines resistance and occurs in strains DBA/1, DBA/2, and CBA/Ca; the allele Rmcfs determines susceptibility and occurs in strains AKR/J, C57BL/6, BALB/c, CBA/J, NFS, NZB, 129/J, and many others. Heterozygotes are as resistant as the resistant parent or nearly so. Rmcf is different from and independent of Fv1,a locus that controls susceptibility to infection by ecotropic viruses. Rmcf is located on Chr 5 close to Hm near the centromeric end (J:7108). Rmcfr protects (AKR x CBA/Ca)F1 and (AKR x DBA/2)F1 hybrids from development of spontaneous thymic lymphomas and reduces the incidence of MCF-induced thymic lymphomas (J:7175). It also reduces susceptibility of cells of Sxvs/Sxvr mice to exogenous xenotropic viruses (J:7951). In addition, in strains susceptible to Friend virus-induced erythroleukemia, a condition thought to be due to the replication of MCF virus, Rmcfr increases resistance to the virus-induced erythroleukemia. It may cause resistance by coding for or regulating the production of an MCF-related envelope glycoprotein that blocks the receptor for MCF viruses (J:8074). This conclusion is reinforced by the findings of Buller et al. (J:8497), who showed that the Rmcfr allele contains an endogenous MCF gp70 env gene and that theRmcfs allele, at least in some strains (C57BL/6, CBA/J, and A/WySn), contains a xenotropic gp70 env gene. Presumably the MCF gp70 inhibits exogenous MCF infection in vitro by a mechanism of viral interference.
Molecular Note		This locus controls resistance of cells to infection by mink cell focus-forming murine leukemia viruses. The recessive s (susceptible) allele is found in AKR/J, C57BL/6, BALB/c, CBA/J, NFS, NZB and 129/J.
Gene Symbol and Name		Emv11, endogenous ecotropic MuLV 11
Chromosome		7
Gene Common Name(s)		AKR leukemia virus inducer 1; Akv-1; Emv-11;
Gene Symbol and Name		Emv14, endogenous ecotropic MuLV 14
Chromosome		11
Gene Common Name(s)		AKR leukemia virus inducer 4; Akv-2J; Akv-4; Emv-14;

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Genotyping resources and troubleshooting

References

References

Selected Reference(s)

Mucenski ML; Taylor BA; Jenkins NA; Copeland NG. 1986. AKXD recombinant inbred strains: models for studying the molecular genetic basis of murine lymphomas. Mol Cell Biol 6(12):4236-43. [PubMed: 3025647]  [MGI Ref ID J:20300]

Additional References

Rmcf^s related

Buller RS; Sitbon M; Portis JL. 1988. The endogenous mink cell focus-forming (MCF) gp70 linked to the Rmcf gene restricts MCF virus replication in vivo and provides partial resistance to erythroleukemia induced by Friend murine leukemia virus. J Exp Med 167(5):1535-46. [PubMed: 2835418]  [MGI Ref ID J:27618]

Hartley JW; Yetter RA; Morse HC 3d. 1983. A mouse gene on chromosome 5 that restricts infectivity of mink cell focus-forming recombinant murine leukemia viruses. J Exp Med 158(1):16-24. [PubMed: 6306133]  [MGI Ref ID J:7108]

Jung YT; Lyu MS; Buckler-White A; Kozak CA. 2002. Characterization of a polytropic murine leukemia virus proviral sequence associated with the virus resistance gene Rmcf of DBA/2 mice. J Virol 76(16):8218-24. [PubMed: 12134027]  [MGI Ref ID J:78083]

Health & husbandry

Health & Colony Maintenance Information

Currently there no information available for this strain. This may be due to the supply level of this strain.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Supply Details

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.

Supply Notes

Cryorecovery - Standard. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location). Genomic DNA is available for this strain from the Mouse DNA Resource.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Terms of Use

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fax:	207-288-6655

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