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Former Names B6;D2-a Es1e/J (Changed: 17-JUL-09 ) STOCK a Es1e/J (Changed: 28-MAR-08 ) Type Mutant Stock; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation ?+F12N1p Description
Mice homozygous for Es1e are viable and fertile and exhibit no apparent defect.Es1e was discovered in a screen of progeny of triethylenemelamine (TEM) treated male mice for mutations at specific loci, but appears to have pre-existed in the male. The screen employed analysis of blood and kidney homogenates by "standard starch gel electrophoresis techniques" and focused on enzymes known to differ in electrophoretic mobility between the parental strains (DBA/2J and C57BL/6J). Es1e was initially thought to be a null allele, but characterization of homozygous F2 mice demonstrated presence of a faint band migrating between those of the parental strains, which was not perceived in the presence of either parental band. Thus, Es1e was shown to be a hypomorphic electrophoretic variant (Soares 1979).
Development
Es1e was discovered in a specific-locus mutation screen of progeny of triethylenemelamine (TEM) mutagenized male DBA/2J mice, but appears to have been a pre-existing, spontaneous mutation. Although the TEM-treated parent was unavailable for genotyping, three lines of evidence suggest he was a heterozygous carrier of the mutation: 7 of 13 (54%) of his immediate offspring were heterozygous for Es1e; he was mated within 2 weeks after TEM treatment, so these progeny were generated from sperm that were either sperm or late spermatids when exposed, ruling out a clustering effect due to mutagenesis at the spermatogonial stage; and the seven Es1e/+ offspring occurred among litters of three dams (Soares 1979).Mice of a strain/stock bearing Es1e, called ES-IE, were imported from Dr. Soares, then at NIEH, by Dr. Eva Eicher in 1979. The original stock was maintained by sister-brother inbreeding. In 1982, Es1e/Es1e males of this stock were bred to C57BL/6J females to produce embryos for cryopreservation. These heterozygous embryos were assigned Stock No. 000785.
Strains carrying a allele
View Strains carrying a (104 strains)
Strains carrying other alleles of Es1
001604 B6.Cg-Es22h Es1b Gusbh/J 001601 B6.YBR-Es1b Es22h/CvJ 002503 ROP/Le-Os Es1a/+ Es1a/J 003118 STOCK Es1e Foxn1nu/J 002974 STOCK Es1e H2d/J View Strains carrying other alleles of Es1 (5 strains)
Strains carrying other alleles of a
View Strains carrying other alleles of a (81 strains)
View Research Applications
Research Applications
This mouse can be used to support research in many areas including:
Metabolism Research
| Allele Symbol | a | ||
|---|---|---|---|
| Allele Name | nonagouti | ||
| Allele Type | Spontaneous | ||
| Gene Symbol and Name | Es1, esterase 1 | ||
| Chromosome | 8 | ||
| Gene Common Name(s) | Ee-1; Es-1; Es-4; Es-N; Es2; MGC109055; esterase 4; esterase related gene-N; | ||
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
Soares ER. 1979. Identification of a new allele of Es-I segregating in an inbred strain of mice. Biochem Genet 17(7-8):577-83. [PubMed: 540008] [MGI Ref ID J:6287]
Currently there no information available for this strain. This may be due to the supply level of this strain.
| Pricing for USA, Canada and Mexico shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
| Pricing for International shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
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| Supply Notes |
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Purchasing Information
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