Description

Strain Information

Former Names AKR/J-Foxn1nu-str    (Changed: 15-DEC-04 ) Hfh11nu-s    (Changed: 15-DEC-04 ) Type Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered Mutant Mice. Species laboratory mouse

Appearance
albino, unaffected
Related Genotype: a/a Tyr^c/Tyr^c +/? or a/a Tyr^c/Tyr^c Foxn1^nu-str/+

unpigmented, without hair
Related Genotype: a/a Tyr^c/Tyr^c Foxn1^nu-str/Foxn1^nu-str

Description
Mice homozygous for the streaker spontaneous have a phenotype that is very similar to nude mice. Homozygosity prevents the development of T cell lymphomas seen in AKR mice.

Development
The nude streaker mutation arose spontaneously in 1974 on the AKR/J inbred background in the laboratory of Dr. Eva Eicher at The Jackson Laboratory. It has been maintained on the AKR/J background, using primarily the backcross-intercross breeding scheme.

Control Information

	Control
	Untyped from the colony
Considerations for Choosing Controls

Related Strains

Strains carrying   Foxn1^nu-str allele

000521

B6.AK-Foxn1nu-str/J

View Strains carrying   Foxn1^nu-str     (1 strain)

Strains carrying other alleles of Foxn1

000819	B6.Cg-Foxn1nu/J
000711	CByJ.Cg-Foxn1nu/J
002019	NU/J
003118	STOCK Es1e Foxn1nu/J

View Strains carrying other alleles of Foxn1     (4 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms

      assigned by genotype

Foxn1^nu-str/Foxn1^nu-str

        AKR/J-Foxn1^nu-str/J

• life span-post-weaning/aging
• premature death (MGI Ref ID J:30715)
  • reduced life span due to susceptibility to infection (ave. 236 days)
• growth/size phenotype
• cachexia (MGI Ref ID J:30715)
  • "wasting disease"
• skin/coat/nails phenotype
• nude (MGI Ref ID J:24755)
• immune system phenotype
• abnormal immune system morphology (MGI Ref ID J:24755)
• abnormal immune system cell morphology (MGI Ref ID J:30715)
• decreased lymphocyte cell number (MGI Ref ID J:30715)
  • peripheral lymphocytes reduced to about 44.2% of white cells as opposed to 78% in controls
• decreased T cell number (MGI Ref ID J:30715)
  • reduced proliferative response to T-cell mitogens
• increased granulocyte number (MGI Ref ID J:30715)
• increased eosinophil cell number (MGI Ref ID J:30715)
  • slightly
• increased neutrophil cell number (MGI Ref ID J:30715)
• abnormal immune system organ morphology (MGI Ref ID J:30715)
• abnormal Peyer's patch morphology (MGI Ref ID J:30715)
  • tissue between primary nodules severely depleted
• abnormal Peyer's patch germinal center morphology (MGI Ref ID J:30715)
  • lack well developed germinal centers
• athymia (MGI Ref ID J:24755)
• lymph node hypoplasia (MGI Ref ID J:30715)
  • deep cortical areas of lymph nodes are severely depleted
• spleen hypoplasia (MGI Ref ID J:30715)
  • periarteriolar regions of spleen severely depleted
• abnormal immune system physiology (MGI Ref ID J:30715)
• abnormal humoral immune response (MGI Ref ID J:30715)
  • decreased humoral response to thymus dependent antigens
  • 20 fold reduction in IgM plaque forming response to sheep erythrocytes
• decreased immunoglobulin level (MGI Ref ID J:30715)
  • decreased serum Ig levels
• increased length of allograft survival (MGI Ref ID J:30715)
• tumorigenesis
• decreased tumor incidence (MGI Ref ID J:43880)
  • no chemically induced carcinogenesis observed in two stage protocols using DMBA and TPA
• increased resistance to lymphoma (MGI Ref ID J:30715)
  • refractory to thymic lymphoma
• sarcoma (MGI Ref ID J:30715)
  • lymphoreticular neoplasms observed (reticulum cell sarcoma)
• hematopoietic system phenotype
• athymia (MGI Ref ID J:24755)
• decreased lymphocyte cell number (MGI Ref ID J:30715)
  • peripheral lymphocytes reduced to about 44.2% of white cells as opposed to 78% in controls
• decreased T cell number (MGI Ref ID J:30715)
  • reduced proliferative response to T-cell mitogens
• increased granulocyte number (MGI Ref ID J:30715)
• increased eosinophil cell number (MGI Ref ID J:30715)
  • slightly
• increased neutrophil cell number (MGI Ref ID J:30715)
• spleen hypoplasia (MGI Ref ID J:30715)
  • periarteriolar regions of spleen severely depleted

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Foxn1^nu-str related

Dermatology Research
Skin and Hair Texture Defects

Immunology and Inflammation Research
Immunodeficiency

Genes & Alleles

Gene & Allele Information

Allele Symbol		Foxn1nu-str
Allele Name		nude streaker
Allele Type		Spontaneous
Common Name(s)		nustr;
Strain of Origin		AKR/J
Gene Symbol and Name		Foxn1, forkhead box N1
Chromosome		11
Gene Common Name(s)		D11Bhm185e; DNA segment, Chr 11, Boehm 185, expressed; FKHL20; HNF-3/forkhead homolog 11; Hfh11; RONU; Rnu; WHN; nu; nude;
Molecular Note		A spontaneous mutation to nude called streaker arose in the AKR/J strain in 1974 at The Jackson Laboratory. An allele test confirmed that streaker is an allele of nude.

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Optimizing PCR Protocols

References

References

Additional References

Hirasawa T; Yamashita H; Makino S. 1998. Genetic typing of the mouse and rat nude mutations by PCR and restriction enzyme analysis. Exp Anim 47(1):63-7. [PubMed: 9498115]  [MGI Ref ID J:46550]

Foxn1^nu-str related

Bedigian HG; Shultz LD; Meier H. 1979. Expression of endogenous murine leukaemia viruses in AKR/J streaker mice. Nature 279(5712):434-436. [PubMed: 16068183]  [MGI Ref ID J:12015]

Eicher EM. 1976. Spontaneous mutations - streaker (nu<str>) and ichthyosis (ic<J>) Mouse News Lett 54:40.  [MGI Ref ID J:24755]

Shultz LD; Bedigian HG; Heiniger HJ; Eicher EM. 1982. The congenitally athymic streaker mouse. In: Proceeding of the Third International Workshop on Nude Mice. Gustav Fischer, New York.  [MGI Ref ID J:30715]

Sundberg JP (ed.). 1994. . In: Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools. CRC Press, Boca Raton.  [MGI Ref ID J:30359]

Sundberg JP; Sundberg BA; Beamer WG. 1997. Comparison of chemical carcinogen skin tumor induction efficacy in inbred, mutant, and hybrid strains of mice: Morphologic variations of induced tumors and absence of a papillomavirus cocarcinogen. Mol Carcinog 20(1):19-32. [PubMed: 9328433]  [MGI Ref ID J:43880]

Health & husbandry

Health & Colony Maintenance Information

Currently there no information available for this strain. This may be due to the supply level of this strain.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Supply Details

Standard Supply

Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.

Supply Notes

Cryopreserved Embryos This strain is also available as cryopreserved embryos from our Repository. Orders for cryopreserved embryos are supplied subject to a signed agreement that must be returned to the Customer Service Department after order placement. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos from our repository, please visit our Cryopreserved Embryos web page. Cryorecovery - Standard. At least two mice that carry the mutation (if it is a mutant strain) will be provided. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotypes and genders are needed. IMPORTANT NOTE: The genotypes of the animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire for possible genotypes for this specific strain. Animals typically ship within 13 to 16 weeks from your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will typically ship within 25 weeks. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 or 1-207-288-5845. This strain is included in the Mouse Mutant Resource collection. Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

	Control
	Untyped from the colony
Considerations for Choosing Controls
USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
International - Control Pricing Information for Genetically Engineered Mutant Strains.

General Terms and Conditions

See Terms of Use

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Ordering and Purchasing Information

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Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form

Terms of Use

Terms of Use

General Terms and Conditions

Contact information

General inquiries

Contracts Administration

phone:	207-288-6470
fax:	207-288-6655

JAX^® Mice & Services Conditions of Use

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