Strain Name:

B6 x 129S1/SvEi Oca2+ Tyr+-Vsx2or-J/J

Stock Number:

000822

Availability:

Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names B6 x 129S1/SvEi p+ Tyr+-Vsx2or-J/J    (Changed: 11-FEB-08 )
B6 x 129S1/SvEi p+ Tyr+-Chx10or-J/J    (Changed: 29-AUG-07 )
B6 x 129/SvEi-+p +Tyr-c Chx10or-J    (Changed: 15-DEC-04 )
Type Mutant Stock;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse
GenerationF58+N1p

Related Strains

Strains carrying   Oca2+ allele
000090   129S1/Sv-Oca2+ Tyr+ KitlSl-J/J
000091   129T1/Sv-Oca2+ Tyrc-ch Dnd1Ter/J
001279   129T1/Sv-Oca2+ Tyrc-ch-Aft/J
000494   J.Cg-Oca2+ Tyr+ Lystbg/J
View Strains carrying   Oca2+     (4 strains)

Strains carrying   Tyr+ allele
000090   129S1/Sv-Oca2+ Tyr+ KitlSl-J/J
005445   A.B6 Tyr+-Cybanmf333/J
005012   A.B6 Tyr+-Myo5ad-l31J/J
002565   A.B6-Tyr+/J
000899   C.B6-Tyr+ Hbbs/J
000494   J.Cg-Oca2+ Tyr+ Lystbg/J
002281   NFS.C58-Tyr+/J
004304   NOD.CBALs-Tyr+/LtJ
View Strains carrying   Tyr+     (8 strains)

Strains carrying   Vsx2or-J allele
000395   129S1/Sv-Vsx2or-J/J
View Strains carrying   Vsx2or-J     (1 strain)

View Strains carrying other alleles of Oca2     (19 strains)

View Strains carrying other alleles of Tyr     (38 strains)

Strains carrying other alleles of Vsx2
001504   NOR2/LtDn-Vsx2or-2J/J
View Strains carrying other alleles of Vsx2     (1 strain)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms
      assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Vsx2or-J/Vsx2or-J

        129S1/Sv
  • vision/eye phenotype
  • abnormal eye development (MGI Ref ID J:5767)
    • by E12 the optic fissure has a thickened inner wall and appears as a plug of retinal layer material
    • in comparison to wildtype only a few necrotic sites are observed in retinal anlage at E12 and existing necrotic sites are restricted to optic stalk
    • hyaloid artery is reduced in homozygotes at E11.5
    • abnormal lens development (MGI Ref ID J:5767)
      • homozygotes exhibit delayed lens formation
    • abnormal optic cup morphology (MGI Ref ID J:5767)
    • abnormal optic stalk morphology (MGI Ref ID J:5767)
      • stalk is reduced in size or absent by E13
    • abnormal retinal progenitor cell morphology (MGI Ref ID J:5767)
  • absent optic nerve (MGI Ref ID J:5767)
    • at weaning, mice have a layer of connective tissue in place of the optic nerve
  • disorganized retinal layers (MGI Ref ID J:5767)
    • retinal layers are uneven and normal cell layers are missing
  • eyelids fail to open (MGI Ref ID J:5767)
  • microphthalmia (MGI Ref ID J:5767)
    • small eyes are observed by E12
  • reduced eye pigmentation (MGI Ref ID J:5767)
  • small lens (MGI Ref ID J:5767)
    • lens is reduced in size and fills most of eyecup
  • nervous system phenotype
  • absent optic nerve (MGI Ref ID J:5767)
    • at weaning, mice have a layer of connective tissue in place of the optic nerve
  • pigmentation phenotype
  • reduced eye pigmentation (MGI Ref ID J:5767)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Tyr+ related

Dermatology Research
Color and White Spotting Defects
      oculocutaneous albinism, type I

Mouse/Human Gene Homologs
albinism, tyrosine negative
      wildtype

Vsx2or-J related
non-syndromic microphthalmia, cataracts and iris abnormalities

Sensorineural Research
Eye Defects

Genes & Alleles

Gene & Allele Information

 
Allele Symbol Oca2+
Allele Name wild type
Allele Type Not Specified
Gene Symbol and Name Oca2, oculocutaneous albinism II
Chromosome 7
Gene Common Name(s) BEY; BEY1; BEY2; BOCA; D15S12; D7H15S12; D7Icr28RN; D7Nic1; DNA segment, Chr 7, Institute for Cancer Research 28RN; DNA segment, Chr 7, Nicholls 1; DNA segment, Chr 7, human D15S12; EYCL; EYCL2; EYCL3; HCL3; P; PED; SHEP1; p; pink-eyed dilution;
 
Allele Symbol Tyr+
Allele Name wild type
Allele Type Not Applicable
Gene Symbol and Name Tyr, tyrosinase
Chromosome 7
Gene Common Name(s) C; OCA1A; OCAIA; SHEP3; albino; c; skc35; skin/coat color 35;
 
Allele Symbol Vsx2or-J
Allele Name ocular retardation Jackson
Allele Type Spontaneous
Common Name(s) Chx10-; orJ;
Strain of Origin129S1/Sv-Oca2<+> Tyr<+> Kitl
Gene Symbol and Name Vsx2, visual system homeobox 2
Chromosome 12
Gene Common Name(s) C. elegans ceh-10 homeo domain containing homolog; CHX10; Chx10; HOX10; Hox-10; MCOP2; MCOPCB3; RET1; homeo box 10 cluster; ocular retardation; or;
General Note Adult homozygotes resemble adult Chx10or/Chx10or mice. Beginning at 10.5 days of gestation there is much cell death in the normal retina but none in that of Chx10or-J/Chx10or-J mice (J:5966, J:5767). Intercellular channels form in the normal retina and continue along the optic stalk, and the optic nerve grows out of the eye through these channels. Presumably as a result of lack of cell death, the intercellular channels are much reduced in Chx10or-J/Chx10or-J eyes. This may be responsible for absence of the optic nerve (J:6121).
Molecular Note The molecular mutation is a premature stop codon in exon 3, corresponding to the homeobox domain of the encoded protein. [MGI Ref ID J:30800] [MGI Ref ID J:32083]

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Genotyping resources and troubleshooting

References

References

Additional References

Bone-Larson C; Basu S; Radel JD; Liang M; Perozek T; Kapousta-Bruneau N; Green DG; Burmeister M; Hankin MH. 2000. Partial rescue of the ocular retardation phenotype by genetic modifiers J Neurobiol 42(2):232-47. [PubMed: 10640330]  [MGI Ref ID J:60051]

Burmeister M; Novak J; Liang MY; Basu S; Ploder L; Hawes NL; Vidgen D; Hoover F; Goldman D; Kalnins VI; Roderick TH; Taylor BA; Hankin MH; McInnes RR. 1996. Ocular retardation mouse caused by Chx10 homeobox null allele: impaired retinal progenitor proliferation and bipolar cell differentiation. Nat Genet 12(4):376-84. [PubMed: 8630490]  [MGI Ref ID J:32083]

Oca2+ related

Mouse Genome Informatics (MGI). 2006. Information obtained from The RIKEN BioResource Center :.  [MGI Ref ID J:104881]

Tyr+ related

Lossie AC; Nakamura H; Thomas SE; Justice MJ. 2005. Mutation of l7Rn3 shows that Odz4 is required for mouse gastrulation. Genetics 169(1):285-99. [PubMed: 15489520]  [MGI Ref ID J:96673]

Miller DA; Dev VG; Tantravahi R; Miller OJ; Schiffman MB; Yates RA; Gluecksohn-Waelsch S. 1974. Cytological detection of the c-25H deletion involving the albino (c) locus on chromosome 7 in the mouse. Genetics 78(3):905-10. [PubMed: 4141683]  [MGI Ref ID J:5520]

Sweet HO. 1987. Acromelanic (c<a>) Mouse News Lett 78:56.  [MGI Ref ID J:14994]

Vsx2or-J related

Behesti H; Papaioannou VE; Sowden JC. 2009. Loss of Tbx2 delays optic vesicle invagination leading to small optic cups. Dev Biol 333(2):360-72. [PubMed: 19576202]  [MGI Ref ID J:152494]

Bharti K; Liu W; Csermely T; Bertuzzi S; Arnheiter H. 2008. Alternative promoter use in eye development: the complex role and regulation of the transcription factor MITF. Development 135(6):1169-78. [PubMed: 18272592]  [MGI Ref ID J:132153]

Bone-Larson C; Basu S; Radel JD; Liang M; Perozek T; Kapousta-Bruneau N; Green DG; Burmeister M; Hankin MH. 2000. Partial rescue of the ocular retardation phenotype by genetic modifiers J Neurobiol 42(2):232-47. [PubMed: 10640330]  [MGI Ref ID J:60051]

Burmeister M; Novak J; Basu S; Ploder L; Liang M; Hawes N; Taylor B; Roderick T; Goldman D; Hankin M; McInnes R. 1994. Ocular retardation (or<J>) has a premature stop codon in the homeobox gene (Chx10). 8th International Mouse Genome Conference, London :24 (Abstr.).  [MGI Ref ID J:30800]

Burmeister M; Novak J; Liang MY; Basu S; Ploder L; Hawes NL; Vidgen D; Hoover F; Goldman D; Kalnins VI; Roderick TH; Taylor BA; Hankin MH; McInnes RR. 1996. Ocular retardation mouse caused by Chx10 homeobox null allele: impaired retinal progenitor proliferation and bipolar cell differentiation. Nat Genet 12(4):376-84. [PubMed: 8630490]  [MGI Ref ID J:32083]

Cicero SA; Johnson D; Reyntjens S; Frase S; Connell S; Chow LM; Baker SJ; Sorrentino BP; Dyer MA. 2009. Cells previously identified as retinal stem cells are pigmented ciliary epithelial cells. Proc Natl Acad Sci U S A 106(16):6685-90. [PubMed: 19346468]  [MGI Ref ID J:148343]

Clark AM; Yun S; Veien ES; Wu YY; Chow RL; Dorsky RI; Levine EM. 2008. Negative regulation of Vsx1 by its paralog Chx10/Vsx2 is conserved in the vertebrate retina. Brain Res 1192:99-113. [PubMed: 17919464]  [MGI Ref ID J:131879]

Coles BL; Horsford DJ; McInnes RR; van der Kooy D. 2006. Loss of retinal progenitor cells leads to an increase in the retinal stem cell population in vivo. Eur J Neurosci 23(1):75-82. [PubMed: 16420417]  [MGI Ref ID J:105261]

Dhomen NS; Balaggan KS; Pearson RA; Bainbridge JW; Levine EM; Ali RR; Sowden JC. 2006. Absence of chx10 causes neural progenitors to persist in the adult retina. Invest Ophthalmol Vis Sci 47(1):386-96. [PubMed: 16384989]  [MGI Ref ID J:104265]

Gao L; Miller RH. 2006. Specification of optic nerve oligodendrocyte precursors by retinal ganglion cell axons. J Neurosci 26(29):7619-28. [PubMed: 16855089]  [MGI Ref ID J:110658]

Gouge A; Holt J; Hardy AP; Sowden JC; Smith HK. 2001. Foxn4 - a new member of the forkhead gene family is expressed in the retina. Mech Dev 107(1-2):203-6. [PubMed: 11520680]  [MGI Ref ID J:71345]

Horsford DJ; Nguyen MT; Sellar GC; Kothary R; Arnheiter H; McInnes RR. 2005. Chx10 repression of Mitf is required for the maintenance of mammalian neuroretinal identity. Development 132(1):177-87. [PubMed: 15576400]  [MGI Ref ID J:94374]

Jones BW; Watt CB; Frederick JM; Baehr W; Chen CK; Levine EM; Milam AH; Lavail MM; Marc RE. 2003. Retinal remodeling triggered by photoreceptor degenerations. J Comp Neurol 464(1):1-16. [PubMed: 12866125]  [MGI Ref ID J:84675]

Khachab MY; Bruce LL. 1999. The development of corticocollicular projections in anophthalmic mice. Brain Res Dev Brain Res 114(2):179-92. [PubMed: 10320757]  [MGI Ref ID J:109169]

Khachab MY; Bruce LL. 1999. The maturation of corticocollicular neurons in mice. Brain Res Dev Brain Res 112(1):145-8. [PubMed: 9974169]  [MGI Ref ID J:109173]

Kokkinopoulos I; Pearson RA; Macneil A; Dhomen NS; Maclaren RE; Ali RR; Sowden JC. 2008. Isolation and characterisation of neural progenitor cells from the adult Chx10(orJ/orJ) central neural retina. Mol Cell Neurosci 38(3):359-73. [PubMed: 18514541]  [MGI Ref ID J:137047]

Ma C; Papermaster D; Cepko CL. 1998. A unique pattern of photoreceptor degeneration in cyclin D1 mutant mice. Proc Natl Acad Sci U S A 95(17):9938-43. [PubMed: 9707579]  [MGI Ref ID J:49399]

Prochazka M; Leiter EH; Cook S; Davisson MT; Bronson R. 1990. or-2J; a new remutation at ocular retardation (or) associated with sterility Mouse Genome 87:93.  [MGI Ref ID J:30714]

Rhoades RW; Mooney RD; Fish SE. 1984. A comparison of visual callosal organization in normal, bilaterally enucleated and congenitally anophthalmic mice. Exp Brain Res 56(1):92-105. [PubMed: 6468571]  [MGI Ref ID J:45405]

Robb RM; Silver J; Sullivan RT. 1978. Ocular retardation (or) in the mouse. Invest Ophthalmol Vis Sci 17(5):468-73. [PubMed: 640793]  [MGI Ref ID J:5966]

Rowan S; Cepko CL. 2005. A POU factor binding site upstream of the Chx10 homeobox gene is required for Chx10 expression in subsets of retinal progenitor cells and bipolar cells. Dev Biol 281(2):240-55. [PubMed: 15893976]  [MGI Ref ID J:98542]

Rowan S; Cepko CL. 2004. Genetic analysis of the homeodomain transcription factor Chx10 in the retina using a novel multifunctional BAC transgenic mouse reporter. Dev Biol 271(2):388-402. [PubMed: 15223342]  [MGI Ref ID J:91498]

Rowan S; Chen CM; Young TL; Fisher DE; Cepko CL. 2004. Transdifferentiation of the retina into pigmented cells in ocular retardation mice defines a new function of the homeodomain gene Chx10. Development 131(20):5139-52. [PubMed: 15459106]  [MGI Ref ID J:93571]

Rutherford AD; Dhomen N; Smith HK; Sowden JC. 2004. Delayed expression of the Crx gene and photoreceptor development in the Chx10-deficient retina. Invest Ophthalmol Vis Sci 45(2):375-84. [PubMed: 14744875]  [MGI Ref ID J:87739]

Sigulinsky CL; Green ES; Clark AM; Levine EM. 2008. Vsx2/Chx10 ensures the correct timing and magnitude of Hedgehog signaling in the mouse retina. Dev Biol 317(2):560-75. [PubMed: 18417110]  [MGI Ref ID J:135151]

Silver J; Robb RM. 1979. Studies on the development of the eye cup and optic nerve in normal mice and in mutants with congenital optic nerve aplasia. Dev Biol 68(1):175-90. [PubMed: 437315]  [MGI Ref ID J:6121]

Theiler K; Varnum DS; Nadeau JH; Stevens LC; Cagianut B. 1976. A new allele of ocular retardation: early development and morphogenetic cell death. Anat Embryol (Berl) 150(1):85-97. [PubMed: 827941]  [MGI Ref ID J:5767]

Wong G; Conger SB; Burmeister M. 2006. Mapping of genetic modifiers affecting the eye phenotype of ocular retardation (Chx10(or-J)) mice. Mamm Genome 17(6):518-25. [PubMed: 16783634]  [MGI Ref ID J:109796]

de Melo J; Du G; Fonseca M; Gillespie LA; Turk WJ; Rubenstein JL; Eisenstat DD. 2005. Dlx1 and Dlx2 function is necessary for terminal differentiation and survival of late-born retinal ganglion cells in the developing mouse retina. Development 132(2):311-22. [PubMed: 15604100]  [MGI Ref ID J:95327]

Health & husbandry

Health & Colony Maintenance Information

Currently there no information available for this strain. This may be due to the supply level of this strain.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations View International pricing
Price (US dollars $)
Cryorecovery Fee $1900.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Additional Supply Details

Pricing for International shipping destinations View USA Canada and Mexico pricing
Price (US dollars $)
Cryorecovery Fee $2470.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Additional Supply Details

Supply Details

Standard SupplyCryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
Supply Notes
  • Cryorecovery - Standard.
    We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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