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Strain Name:

B6 x 129S1/SvEi Oca2+ Tyr+-Vsx2or-J/J

Stock Number:

000822

Availability:

Repository-Cryopreserved


General Terms and Conditions

Former Name      B6 x 129S1/SvEi p+ Tyr+-Vsx2or-J/J    (Changed: 11-FEB-08 )
      B6 x 129S1/SvEi p+ Tyr+-Chx10or-J/J    (Changed: 29-AUG-07 )
      B6 x 129/SvEi-+p +Tyr-c Chx10or-J    (Changed: 15-DEC-04 )
Genes & Alleles   Oca2;   Oca2+;   Tyr;   Tyr+;   Vsx2;   Vsx2or-J;


Product Information

Strain Details

Type JAX® GEMM® Strain - Mutant Stock
Additional information on JAX® GEMM® Strains.
Specieslaboratory mouse
GenerationF58+N1p
Mammalian Phenotype Terms assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Vsx2or-J/Vsx2or-J

        129S1/Sv
  • vision/eye phenotype
  • abnormal eye development (MGI Ref ID J:5767)
    • by E12 the optic fissure has a thickened inner wall and appears as a plug of retinal layer material
    • in comparison to wildtype only a few necrotic sites are observed in retinal anlage at E12 and existing necrotic sites are restricted to optic stalk
    • hyaloid artery is reduced in homozygotes at E11.5
    • abnormal lens development (MGI Ref ID J:5767)
      • homozygotes exhibit delayed lens formation
    • abnormal optic cup morphology (MGI Ref ID J:5767)
    • abnormal optic stalk morphology (MGI Ref ID J:5767)
      • stalk is reduced in size or absent by E13
    • abnormal retinal progenitor morphology (MGI Ref ID J:5767)
  • absent optic nerve (MGI Ref ID J:5767)
    • at weaning, mice have a layer of connective tissue in place of the optic nerve
  • disorganized retinal layers (MGI Ref ID J:5767)
    • retinal layers are uneven and normal cell layers are missing
  • eyelids fail to open (MGI Ref ID J:5767)
  • microphthalmia (MGI Ref ID J:5767)
    • small eyes are observed by E12
  • reduced eye pigmentation (MGI Ref ID J:5767)
  • small lens (MGI Ref ID J:5767)
    • lens is reduced in size and fills most of eyecup
  • nervous system phenotype
  • absent optic nerve (MGI Ref ID J:5767)
    • at weaning, mice have a layer of connective tissue in place of the optic nerve
  • pigmentation phenotype
  • reduced eye pigmentation (MGI Ref ID J:5767)

Gene & Allele Details

Allele Symbol Oca2+
Allele Name wild type
Gene Symbol and Name Oca2, oculocutaneous albinism II
Chromosome 7
Gene Common Name(s) BEY; BEY1; BEY2; BOCA; D15S12; D7H15S12; D7Icr28RN; D7Nic1; DNA segment, Chr 7, Institute for Cancer Research 28RN; DNA segment, Chr 7, Nicholls 1; DNA segment, Chr 7, human D15S12; EYCL; EYCL2; EYCL3; HCL3; P; PED; SHEP1; p; pink-eyed dilution;
 
Allele Symbol Tyr+
Allele Name wild type
Gene Symbol and Name Tyr, tyrosinase
Chromosome 7
Gene Common Name(s) C; OCA1A; OCAIA; SHEP3; albino; c; skc35; skin/coat color 35;
 
Allele Symbol Vsx2or-J
Allele Name ocular retardation Jackson
Common Name(s) Chx10-; orJ;
Strain of Origin129S1/Sv-Oca2<+> Tyr<+> Kitl
Gene Symbol and Name Vsx2, visual system homeobox 2
Chromosome 12
Gene Common Name(s) C. elegans ceh-10 homeo domain containing homolog; CHX10; Chx10; HOX10; Hox-10; MCOP2; MCOPCB3; RET1; homeo box 10 cluster; ocular retardation; or;
General Note Adult homozygotes resemble adult Chx10or/Chx10or mice. Beginning at 10.5 days of gestation there is much cell death in the normal retina but none in that of Chx10or-J/Chx10or-J mice (J:5966, J:5767). Intercellular channels form in the normal retina and continue along the optic stalk, and the optic nerve grows out of the eye through these channels. Presumably as a result of lack of cell death, the intercellular channels are much reduced in Chx10or-J/Chx10or-J eyes. This may be responsible for absence of the optic nerve (J:6121). Chx10or-J/Chx10or-J homozygotes are fully fertile in both sexes (J:30714).
Molecular Note The molecular mutation is a premature stop codon in exon 3, corresponding to the homeobox domain of the encoded protein. [MGI Ref ID J:30800] [MGI Ref ID J:32083]

Related Strains

Strains carrying   Oca2+ allele
000090   129S1/Sv-Oca2+ Tyr+ KitlSl-J/J
000091   129T1/Sv-Oca2+ Tyrc-ch Dnd1Ter/J
001279   129T1/Sv-Oca2+ Tyrc-ch-Aft/J
000494   J.Cg-Oca2+ Tyr+ Lystbg/J
View Strains carrying   Oca2+     (4 strains)

Strains carrying   Tyr+ allele
000090   129S1/Sv-Oca2+ Tyr+ KitlSl-J/J
005445   A.B6 Tyr+-Cybanmf333/J
005012   A.B6 Tyr+-Myo5ad-l31J/J
002565   A.B6-Tyr+/J
000899   C.B6-Tyr+ Hbbs/J
000494   J.Cg-Oca2+ Tyr+ Lystbg/J
002281   NFS.C58-Tyr+/J
004304   NOD.CBALs-Tyr+/LtJ
View Strains carrying   Tyr+     (8 strains)

Strains carrying   Vsx2or-J allele
000395   129S1/Sv-Vsx2or-J/J
View Strains carrying   Vsx2or-J     (1 strain)

View Strains carrying other alleles of Oca2     (19 strains)

View Strains carrying other alleles of Tyr     (38 strains)

Strains carrying other alleles of Vsx2
001504   NOR2/LtDn-Vsx2or-2J/J
View Strains carrying other alleles of Vsx2     (1 strain)

Research Applications

This mouse can be used to support research in many areas including:

Tyr+ related

Dermatology Research
Color and White Spotting Defects (oculocutaneous albinism, type I)

Mouse/Human Gene Homologs
albinism, tyrosine negative (wildtype)

Vsx2or-J related
non-syndromic microphthalmia, cataracts and iris abnormalities

Sensorineural Research
Eye Defects

References

Additional References

Price and Supply Information

Strain Name: B6 x 129S1/SvEi Oca2+ Tyr+-Vsx2or-J/J
Stock Number: 000822

Price Details

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Supply Details

Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes Cryorecovery - Standard.
The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.

Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services: Tel: 1-800-422-6423 or 1-207-288-5845; Email: jaxservices@jax.org.

LicensingSee General Terms and Conditions below  

General Terms and Conditions

View JAX® Mice & Services Conditions of Use.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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