JAX Mice Database - 000822 B6 x 129S1/SvEi Oca2<+> Tyr<+>-Vsx2<or-J>/J

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Strain Name:	B6 x 129S1/SvEi Oca2⁺ Tyr⁺-Vsx2^or-J/J
Stock Number:	000822
Availability:	Repository-Cryopreserved

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General Terms and Conditions

Former Name	B6 x 129S1/SvEi p⁺ Tyr⁺-Vsx2^or-J/J (Changed: 11-FEB-08 )
	B6 x 129S1/SvEi p⁺ Tyr⁺-Chx10^or-J/J (Changed: 29-AUG-07 )
	B6 x 129/SvEi-+^p +^Tyr-c Chx10^or-J (Changed: 15-DEC-04 )
Genes & Alleles	Oca2; Oca2⁺; Tyr; Tyr⁺; Vsx2; Vsx2^or-J;

Product Information

Strain Details

Type JAX^® GEMM^® Strain - Mutant Stock

Additional information on JAX^® GEMM^® Strains.

Species laboratory mouse

Generation F58+N1p

Mammalian Phenotype Terms assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX^® Mice strain.
Vsx2^or-J/Vsx2^or-J
129S1/Sv
vision/eye phenotype

abnormal eye development (MGI Ref ID J:5767)

by E12 the optic fissure has a thickened inner wall and appears as a plug of retinal layer material

in comparison to wildtype only a few necrotic sites are observed in retinal anlage at E12 and existing necrotic sites are restricted to optic stalk

hyaloid artery is reduced in homozygotes at E11.5

abnormal lens development (MGI Ref ID J:5767)

homozygotes exhibit delayed lens formation

abnormal optic cup morphology (MGI Ref ID J:5767)

abnormal optic stalk morphology (MGI Ref ID J:5767)

stalk is reduced in size or absent by E13

abnormal retinal progenitor morphology (MGI Ref ID J:5767)

absent optic nerve (MGI Ref ID J:5767)

at weaning, mice have a layer of connective tissue in place of the optic nerve

disorganized retinal layers (MGI Ref ID J:5767)

retinal layers are uneven and normal cell layers are missing

eyelids fail to open (MGI Ref ID J:5767)

microphthalmia (MGI Ref ID J:5767)

small eyes are observed by E12

reduced eye pigmentation (MGI Ref ID J:5767)

small lens (MGI Ref ID J:5767)

lens is reduced in size and fills most of eyecup

nervous system phenotype

absent optic nerve (MGI Ref ID J:5767)

at weaning, mice have a layer of connective tissue in place of the optic nerve

pigmentation phenotype

reduced eye pigmentation (MGI Ref ID J:5767)

Gene & Allele Details

Allele Symbol		Oca2⁺
Allele Name		wild type
Gene Symbol and Name		Oca2, oculocutaneous albinism II
Chromosome		7
Gene Common Name(s)		BEY; BEY1; BEY2; BOCA; D15S12; D7H15S12; D7Icr28RN; D7Nic1; DNA segment, Chr 7, Institute for Cancer Research 28RN; DNA segment, Chr 7, Nicholls 1; DNA segment, Chr 7, human D15S12; EYCL; EYCL2; EYCL3; HCL3; P; PED; SHEP1; p; pink-eyed dilution;

Allele Symbol		Tyr⁺
Allele Name		wild type
Gene Symbol and Name		Tyr, tyrosinase
Chromosome		7
Gene Common Name(s)		C; OCA1A; OCAIA; SHEP3; albino; c; skc35; skin/coat color 35;

Allele Symbol		Vsx2^or-J
Allele Name		ocular retardation Jackson
Common Name(s)		Chx10^-; orJ;
Strain of Origin		129S1/Sv-Oca2<+> Tyr<+> Kitl
Gene Symbol and Name		Vsx2, visual system homeobox 2
Chromosome		12
Gene Common Name(s)		C. elegans ceh-10 homeo domain containing homolog; CHX10; Chx10; HOX10; Hox-10; MCOP2; MCOPCB3; RET1; homeo box 10 cluster; ocular retardation; or;
General Note		Adult homozygotes resemble adult Chx10^or/Chx10^or mice. Beginning at 10.5 days of gestation there is much cell death in the normal retina but none in that of Chx10^or-J/Chx10^or-J mice (J:5966, J:5767). Intercellular channels form in the normal retina and continue along the optic stalk, and the optic nerve grows out of the eye through these channels. Presumably as a result of lack of cell death, the intercellular channels are much reduced in Chx10^or-J/Chx10^or-J eyes. This may be responsible for absence of the optic nerve (J:6121). Chx10^or-J/Chx10^or-J homozygotes are fully fertile in both sexes (J:30714).
Molecular Note		The molecular mutation is a premature stop codon in exon 3, corresponding to the homeobox domain of the encoded protein. [MGI Ref ID J:30800] [MGI Ref ID J:32083]

Related Strains

Strains carrying Oca2⁺ allele

000090 129S1/Sv-Oca2⁺ Tyr⁺ Kitl^Sl-J/J

000091 129T1/Sv-Oca2⁺ Tyr^c-ch Dnd1^Ter/J

001279 129T1/Sv-Oca2⁺ Tyr^c-ch-Aft/J

000494 J.Cg-Oca2⁺ Tyr⁺ Lyst^bg/J

View Strains carrying Oca2⁺ (4 strains)

Strains carrying Tyr⁺ allele

000090 129S1/Sv-Oca2⁺ Tyr⁺ Kitl^Sl-J/J

005445 A.B6 Tyr⁺-Cyba^nmf333/J

005012 A.B6 Tyr⁺-Myo5a^d-l31J/J

002565 A.B6-Tyr⁺/J

000899 C.B6-Tyr⁺ Hbb^s/J

000494 J.Cg-Oca2⁺ Tyr⁺ Lyst^bg/J

002281 NFS.C58-Tyr⁺/J

004304 NOD.CBALs-Tyr⁺/LtJ

View Strains carrying Tyr⁺ (8 strains)

Strains carrying Vsx2^or-J allele

000395 129S1/Sv-Vsx2^or-J/J

View Strains carrying Vsx2^or-J (1 strain)

Strains carrying other alleles of Oca2

000004 ABP/LeJ

000577 B6 x STOCK a Oca2^p Hps5^ru2 Ednrb^s/J

001059 B6By.Cg-Oca2^p/J

002460 C3H/HeJ-Oca2^p-J Is(7;1)40H/J

000513 C3H/HeJ-Oca2^p-J/J

001136 C57BL/6J-Oca2^p-un+2J/J

001506 C57BL/6J-Oca2^p-un+3J/J

001810 C57BL/6J-Oca2^p-un+4J/J

001513 C57BL/6J-Oca2^p-un+5J/J

001499 C57BL/6J-Oca2^p-un+6J/J

001033 C57BL/6J-Oca2^p-un+J/J

000028 C57BL/6J-Oca2^p-un/J

000619 FS/EiJ

000306 STOCK Dll3^pu + Tyr^c-ch/+ Oca2^p Tyr^c-ch/J

001584 STOCK Oca2^p-J/Oca2^p-bs/J

001585 STOCK Oca2^p-d/Oca2^p-25H/J

000823 STOCK Oca2^p-d/Oca2^p-6H/J

001747 STOCK Oca2^p-d/Oca2^p-cp/J

001618 STOCK Oca2^p/Oca2^p Prop1^df/J

View Strains carrying other alleles of Oca2 (19 strains)

Strains carrying other alleles of Tyr

000091 129T1/Sv-Oca2⁺ Tyr^c-ch Dnd1^Ter/J

001279 129T1/Sv-Oca2⁺ Tyr^c-ch-Aft/J

001017 AKXD10/TyJ

000765 AKXD13/TyJ

000954 AKXD15/TyJ

000958 AKXD16/TyJ

001093 AKXD18/TyJ

001062 AKXD21/TyJ

000947 AKXD22/TyJ

000969 AKXD24/TyJ

000777 AKXD6/TyJ

000763 AKXD9/TyJ

000409 B10.129P-H1^b Hbb^d Tyr^c Ea7^a/(5M)oSnJ

000418 B10.129P-H1^b Tyr^c Hbb^d/(5M)nSnJ

000432 B10.C-H1^b Hbb^d Tyr^c/(41N)SnJ

000580 B10.D2/nSn-Tyr^c-4J/J

000578 B6 x STOCK Tyr^c-ch Bmp5^se +/+ Myo6^sv/J

000058 B6(Cg)-Tyr^c-2J/J

000383 B6.C-Tyr^c H1^b Hbb^d/ByJ

007484 B6.Cg-Tyr^c-2J Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ

000035 B6.Cg-Tyr^c-J/J

000104 B6.Cg-Tyr^c-h/J

000054 B6.D2-Tyr^c-p/J

000339 C3H/HeJ-Tyr^c-9J/J

001294 C3H/HeJ-Tyr^c-a/J

001002 C57BL/10SnJ-Tyr^c-11J/J

001006 CBA/J-Tyr^c-10J/J

000657 CE/J

000619 FS/EiJ

004828 FVB.129P2-Pde6b⁺ Tyr^c-ch/AntJ

007483 FVB.Cg-Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ

005115 NOD.FVB-Tg(INS-MT2A,Tyr)1Pne/PneJ

005114 NOD.FVB-Tg(Ins1-Cat,Tyr)25Pne/PneJ

000271 SH1/LeJ

001759 STOCK A Tyr^c Sha/J

000306 STOCK Dll3^pu + Tyr^c-ch/+ Oca2^p Tyr^c-ch/J

000006 STOCK Hk Tyr^c/J

000206 STOCK a/a Tyr^c-h/J

View Strains carrying other alleles of Tyr (38 strains)

Strains carrying other alleles of Vsx2

001504 NOR2/LtDn-Vsx2^or-2J/J

View Strains carrying other alleles of Vsx2 (1 strain)

Research Applications

This mouse can be used to support research in many areas including:

Tyr⁺ related

Dermatology Research
Color and White Spotting Defects (oculocutaneous albinism, type I)

Mouse/Human Gene Homologs
albinism, tyrosine negative (wildtype)

Vsx2^or-J related

non-syndromic microphthalmia, cataracts and iris abnormalities

Sensorineural Research
Eye Defects

References

Additional References

Price and Supply Information

Strain Name:	*B6 x 129S1/SvEi Oca2⁺ Tyr⁺-Vsx2^or-J/J*
Stock Number:	000822

Price Details

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Supply Details

Standard Supply	Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes	Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. *Cryorecovery to establish a Dedicated Supply for greater quantities of mice.* One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX^® Services: Tel: 1-800-422-6423 or 1-207-288-5845; Email: jaxservices@jax.org.
Licensing	See General Terms and Conditions below

General Terms and Conditions

View JAX^® Mice & Services Conditions of Use.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Fax: 207.288.6150
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Go to JAX^® Mice Query Form

000090	129S1/Sv-Oca2⁺ Tyr⁺ Kitl^Sl-J/J
000091	129T1/Sv-Oca2⁺ Tyr^c-ch Dnd1^Ter/J
001279	129T1/Sv-Oca2⁺ Tyr^c-ch-Aft/J
000494	J.Cg-Oca2⁺ Tyr⁺ Lyst^bg/J

000090	129S1/Sv-Oca2⁺ Tyr⁺ Kitl^Sl-J/J
005445	A.B6 Tyr⁺-Cyba^nmf333/J
005012	A.B6 Tyr⁺-Myo5a^d-l31J/J
002565	A.B6-Tyr⁺/J
000899	C.B6-Tyr⁺ Hbb^s/J
000494	J.Cg-Oca2⁺ Tyr⁺ Lyst^bg/J
002281	NFS.C58-Tyr⁺/J
004304	NOD.CBALs-Tyr⁺/LtJ

000004	ABP/LeJ
000577	B6 x STOCK a Oca2^p Hps5^ru2 Ednrb^s/J
001059	B6By.Cg-Oca2^p/J
002460	C3H/HeJ-Oca2^p-J Is(7;1)40H/J
000513	C3H/HeJ-Oca2^p-J/J
001136	C57BL/6J-Oca2^p-un+2J/J
001506	C57BL/6J-Oca2^p-un+3J/J
001810	C57BL/6J-Oca2^p-un+4J/J
001513	C57BL/6J-Oca2^p-un+5J/J
001499	C57BL/6J-Oca2^p-un+6J/J
001033	C57BL/6J-Oca2^p-un+J/J
000028	C57BL/6J-Oca2^p-un/J
000619	FS/EiJ
000306	STOCK Dll3^pu + Tyr^c-ch/+ Oca2^p Tyr^c-ch/J
001584	STOCK Oca2^p-J/Oca2^p-bs/J
001585	STOCK Oca2^p-d/Oca2^p-25H/J
000823	STOCK Oca2^p-d/Oca2^p-6H/J
001747	STOCK Oca2^p-d/Oca2^p-cp/J
001618	STOCK Oca2^p/Oca2^p Prop1^df/J

Strain Name:

B6 x 129S1/SvEi Oca2+ Tyr+-Vsx2or-J/J

Stock Number:

000822

Availability:

Repository-Cryopreserved

General Terms and Conditions

Product Information

Strain Details

Vsx2or-J/Vsx2or-J

Gene & Allele Details

Related Strains

Research Applications

References

Price and Supply Information

Price Details

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Supply Details

General Terms and Conditions

The Jackson Laboratory's Genotype Promise

B6 x 129S1/SvEi Oca2⁺ Tyr⁺-Vsx2^or-J/J

Vsx2^or-J/Vsx2^or-J