Strain Name:

B6 x 129S1/SvEi Oca2+ Tyr+-Vsx2or-J/J

Stock Number:

000822

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Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names B6 x 129S1/SvEi p+ Tyr+-Vsx2or-J/J    (Changed: 11-FEB-08 )
B6 x 129S1/SvEi p+ Tyr+-Chx10or-J/J    (Changed: 29-AUG-07 )
B6 x 129/SvEi-+p +Tyr-c Chx10or-J    (Changed: 15-DEC-04 )
Type Mutant Stock; Spontaneous Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse
GenerationF58+N1p
Generation Definitions

Related Strains

Strains carrying   Oca2+ allele
000090   129S1/Sv-Oca2+ Tyr+ KitlSl-J/J
001279   129T1/Sv-Oca2+ Tyrc-ch Aft/J
000091   129T1/Sv-Oca2+ Tyrc-ch Dnd1Ter/J
000494   J.Cg-Oca2+ Tyr+ Lystbg/J
View Strains carrying   Oca2+     (4 strains)

Strains carrying   Tyr+ allele
000090   129S1/Sv-Oca2+ Tyr+ KitlSl-J/J
005445   A.B6 Tyr+-Cybanmf333/J
005012   A.B6 Tyr+-Myo5ad-l31J/J
002565   A.B6-Tyr+/J
000899   C.B6-Tyr+ Hbbs/J
000494   J.Cg-Oca2+ Tyr+ Lystbg/J
002281   NFS.C58-Tyr+/J
004304   NOD.CBALs-Tyr+/LtJ
View Strains carrying   Tyr+     (8 strains)

Strains carrying   Vsx2or-J allele
000395   129S1/Sv-Vsx2or-J/J
View Strains carrying   Vsx2or-J     (1 strain)

View Strains carrying other alleles of Oca2     (18 strains)

Strains carrying other alleles of Tyr
000091   129T1/Sv-Oca2+ Tyrc-ch Dnd1Ter/J
001017   AKXD10/TyJ
000765   AKXD13/TyJ
000954   AKXD15/TyJ
000958   AKXD16/TyJ
001093   AKXD18/TyJ
001062   AKXD21/TyJ
000947   AKXD22/TyJ
000969   AKXD24/TyJ
000777   AKXD6/TyJ
000763   AKXD9/TyJ
000409   B10.129P-H1b Hbbd Tyrc Ea7a/(5M)oSnJ
000418   B10.129P-H1b Tyrc Hbbd/(5M)nSnJ
000432   B10.C-H1b Hbbd Tyrc/(41N)SnJ
000580   B10.D2/nSn-Tyrc-4J/J
000578   B6 x STOCK Tyrc-ch Bmp5se +/+ Myo6sv/J
017614   B6(Cg)-Tyrc-2J Tg(UBC-mCherry)1Phbs/J
000058   B6(Cg)-Tyrc-2J/J
008647   B6.129P2(Cg)-Trpa1tm1.1Kykw Tyrc-2J/J
000383   B6.C-Tyrc H1b Hbbd/ByJ
013590   B6.Cg-Braftm1Mmcm Ptentm1Hwu Tg(Tyr-cre/ERT2)13Bos/BosJ
003819   B6.Cg-Per2tm1Brd Tyrc-Brd/J
023429   B6.Cg-Tyrc-2J Cdkn1atm1Hpw/J
007484   B6.Cg-Tyrc-2J Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
000035   B6.Cg-Tyrc-J/J
000104   B6.Cg-Tyrc-h/J
005349   B6.Cg-awag Tyrc-2J/GrsrJ
012328   B6.Cg-Tg(Tyr-cre/ERT2)13Bos/J
000054   B6.D2-Tyrc-p/J
023428   B6;129X1-Tyrc-2J Cdkn1atm2Hpw/J
000339   C3H/HeJ-Tyrc-9J/J
001294   C3H/HeJ-Tyrc-a/J
001002   C57BL/10SnJ-Tyrc-11J/J
021999   C57BL/6NJ-Tyrem3J/GrsrJ
012257   CB6-Tg(Tyr-TAg)BJjw/Mmjax
001006   CBA/J-Tyrc-10J/J
000657   CE/J
000619   FS/EiJ
004624   FVB.129P2-Pde6b+ Tyrc-ch Fmr1tm1Cgr/J
004828   FVB.129P2-Pde6b+ Tyrc-ch/AntJ
007483   FVB.Cg-Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
000271   SH1/LeJ
001759   STOCK A Tyrc Sha/J
000306   STOCK Dll3pu + Tyrc-ch/+ Oca2p Tyrc-ch/J
018129   STOCK Fah1R Tyrc/RJ
000006   STOCK Hk Tyrc/J
014173   STOCK Omptm1.1(COP4*/EYFP)Tboz/J
000206   STOCK a/a Tyrc-h/J
View Strains carrying other alleles of Tyr     (48 strains)

Strains carrying other alleles of Vsx2
001504   NOR2/LtDn-Vsx2or-2J/J
View Strains carrying other alleles of Vsx2     (1 strain)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Microphthalmia, Isolated 2; MCOP2   (VSX2)
Microphthalmia, Isolated, with Coloboma 3; MCOPCB3   (VSX2)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Vsx2or-J/Vsx2or-J

        129S1/Sv
  • vision/eye phenotype
  • abnormal eye development
    • in comparison to wild-type only a few necrotic sites are observed in retinal anlage at E12 and existing necrotic sites are restricted to optic stalk   (MGI Ref ID J:5767)
    • abnormal hyaloid artery morphology
      • hyaloid artery is reduced in homozygotes at E11.5   (MGI Ref ID J:5767)
    • abnormal lens development
      • homozygotes exhibit delayed lens formation   (MGI Ref ID J:5767)
    • abnormal optic cup morphology   (MGI Ref ID J:5767)
    • abnormal optic fissure morphology
      • by E12 the optic fissure has a thickened inner wall and appears as a plug of retinal layer material   (MGI Ref ID J:5767)
    • abnormal optic stalk morphology
      • stalk is reduced in size or absent by E13   (MGI Ref ID J:5767)
    • abnormal retinal progenitor cell morphology   (MGI Ref ID J:5767)
  • absent optic nerve
    • at weaning, mice have a layer of connective tissue in place of the optic nerve   (MGI Ref ID J:5767)
  • decreased eye pigmentation   (MGI Ref ID J:5767)
  • disorganized retinal layers
    • retinal layers are uneven and normal cell layers are missing   (MGI Ref ID J:5767)
  • eyelids fail to open   (MGI Ref ID J:5767)
  • microphthalmia
    • small eyes are observed by E12   (MGI Ref ID J:5767)
  • small lens
    • lens is reduced in size and fills most of eyecup   (MGI Ref ID J:5767)
  • nervous system phenotype
  • absent optic nerve
    • at weaning, mice have a layer of connective tissue in place of the optic nerve   (MGI Ref ID J:5767)
  • pigmentation phenotype
  • decreased eye pigmentation   (MGI Ref ID J:5767)

Vsx2or-J/Vsx2or-J

        involves: 129S1/Sv
  • vision/eye phenotype
  • abnormal retina morphology   (MGI Ref ID J:190452)
    • abnormal retinal development
      • onset of neurogenesis is delayed by 1-2 days in the retina   (MGI Ref ID J:190452)
    • abnormal retinal pigment epithelium morphology
      • abnormal retinal pigmentation
        • ectopic pigmentation of the retina   (MGI Ref ID J:190452)
    • decreased total retina thickness   (MGI Ref ID J:190452)
  • microphthalmia
    • by E11.5   (MGI Ref ID J:190452)
    • becomes progressively more severe with age   (MGI Ref ID J:190452)
  • small lens   (MGI Ref ID J:190452)
  • pigmentation phenotype
  • abnormal retinal pigment epithelium morphology
    • abnormal retinal pigmentation
      • ectopic pigmentation of the retina   (MGI Ref ID J:190452)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Tyr+ related

Dermatology Research
Color and White Spotting Defects
      oculocutaneous albinism, type I

Vsx2or-J related

Sensorineural Research
Eye Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Oca2+
Allele Name wild type
Allele Type Not Applicable
Gene Symbol and Name Oca2, oculocutaneous albinism II
Chromosome 7
Gene Common Name(s) BEY; BEY1; BEY2; BOCA; D15S12; D7H15S12; D7Icr28RN; D7Nic1; DNA segment, Chr 7, Institute for Cancer Research 28RN; DNA segment, Chr 7, Nicholls 1; DNA segment, Chr 7, human D15S12; EYCL; EYCL2; EYCL3; HCL3; P; PED; SHEP1; p; pink-eyed dilution;
 
Allele Symbol Tyr+
Allele Name wild type
Allele Type Not Applicable
Gene Symbol and Name Tyr, tyrosinase
Chromosome 7
Gene Common Name(s) ATN; C; CMM8; OCA1; OCA1A; OCAIA; SHEP3; albino; c; skc35; skin/coat color 35;
 
Allele Symbol Vsx2or-J
Allele Name ocular retardation Jackson
Allele Type Spontaneous
Common Name(s) Chx10-; orJ;
Strain of Origin129S1/Sv-Oca2<+> Tyr<+> Kitl
Gene Symbol and Name Vsx2, visual system homeobox 2
Chromosome 12
Gene Common Name(s) C. elegans ceh-10 homeo domain containing homolog; CHX10; Chx10; HOX10; Hox-10; MCOP2; MCOPCB3; RET1; homeo box 10 cluster; ocular retardation; or;
General Note Adult homozygotes resemble adult Chx10or/Chx10or mice. Beginning at 10.5 days of gestation there is much cell death in the normal retina but none in that of Chx10or-J/Chx10or-J mice (J:5966, J:5767). Intercellular channels form in the normal retina and continue along the optic stalk, and the optic nerve grows out of the eye through these channels. Presumably as a result of lack of cell death, the intercellular channels are much reduced in Chx10or-J/Chx10or-J eyes. This may be responsible for absence of the optic nerve (J:6121).
Molecular Note The molecular mutation is a premature stop codon in exon 3, corresponding to the homeobox domain of the encoded protein. [MGI Ref ID J:30800] [MGI Ref ID J:32083]

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Bone-Larson C; Basu S; Radel JD; Liang M; Perozek T; Kapousta-Bruneau N; Green DG; Burmeister M; Hankin MH. 2000. Partial rescue of the ocular retardation phenotype by genetic modifiers J Neurobiol 42(2):232-47. [PubMed: 10640330]  [MGI Ref ID J:60051]

Burmeister M; Novak J; Liang MY; Basu S; Ploder L; Hawes NL; Vidgen D; Hoover F; Goldman D; Kalnins VI; Roderick TH; Taylor BA; Hankin MH; McInnes RR. 1996. Ocular retardation mouse caused by Chx10 homeobox null allele: impaired retinal progenitor proliferation and bipolar cell differentiation. Nat Genet 12(4):376-84. [PubMed: 8630490]  [MGI Ref ID J:32083]

Oca2+ related

Haldane JBS; Sprunt AD; Haldane NM. 1915. Reduplication in mice J Genet 5:133-135.  [MGI Ref ID J:100]

The RIKEN BioResource Center. 2006. Information obtained from The RIKEN BioResource Center Unpublished :.  [MGI Ref ID J:104881]

Tyr+ related

Erickson RP; Gluecksohn-Waelsch S; Cori CF. 1968. Glucose-6-phosphatase deficiency caused by radiation-induced alleles at the albino locus in the mouse. Proc Natl Acad Sci U S A 59(2):437-44. [PubMed: 4296364]  [MGI Ref ID J:5063]

Lossie AC; Nakamura H; Thomas SE; Justice MJ. 2005. Mutation of l7Rn3 shows that Odz4 is required for mouse gastrulation. Genetics 169(1):285-99. [PubMed: 15489520]  [MGI Ref ID J:96673]

Miller DA; Dev VG; Tantravahi R; Miller OJ; Schiffman MB; Yates RA; Gluecksohn-Waelsch S. 1974. Cytological detection of the c-25H deletion involving the albino (c) locus on chromosome 7 in the mouse. Genetics 78(3):905-10. [PubMed: 4141683]  [MGI Ref ID J:5520]

Oak Ridge National Laboratory. 2005. Information obtained from the Oak Ridge National Laboratory Mutant Mouse Database (ORNL), Oak Ridge, TN Unpublished :.  [MGI Ref ID J:100221]

Sweet HO. 1987. Acromelanic (c<a>) Mouse News Lett 78:56.  [MGI Ref ID J:14994]

Taibi AV; Lighthouse JK; Grady RC; Shroyer KR; Holdener BC. 2013. Development of a conditional Mesd (mesoderm development) allele for functional analysis of the low-density lipoprotein receptor-related family in defined tissues. PLoS One 8(10):e75782. [PubMed: 24124512]  [MGI Ref ID J:209024]

Vsx2or-J related

Behesti H; Papaioannou VE; Sowden JC. 2009. Loss of Tbx2 delays optic vesicle invagination leading to small optic cups. Dev Biol 333(2):360-72. [PubMed: 19576202]  [MGI Ref ID J:152494]

Bharti K; Liu W; Csermely T; Bertuzzi S; Arnheiter H. 2008. Alternative promoter use in eye development: the complex role and regulation of the transcription factor MITF. Development 135(6):1169-78. [PubMed: 18272592]  [MGI Ref ID J:132153]

Bone-Larson C; Basu S; Radel JD; Liang M; Perozek T; Kapousta-Bruneau N; Green DG; Burmeister M; Hankin MH. 2000. Partial rescue of the ocular retardation phenotype by genetic modifiers J Neurobiol 42(2):232-47. [PubMed: 10640330]  [MGI Ref ID J:60051]

Burmeister M; Novak J; Basu S; Ploder L; Liang M; Hawes N; Taylor B; Roderick T; Goldman D; Hankin M; McInnes R. 1994. Ocular retardation (or<J>) has a premature stop codon in the homeobox gene (Chx10). 8th International Mouse Genome Conference, London :24 (Abstr.).  [MGI Ref ID J:30800]

Burmeister M; Novak J; Liang MY; Basu S; Ploder L; Hawes NL; Vidgen D; Hoover F; Goldman D; Kalnins VI; Roderick TH; Taylor BA; Hankin MH; McInnes RR. 1996. Ocular retardation mouse caused by Chx10 homeobox null allele: impaired retinal progenitor proliferation and bipolar cell differentiation. Nat Genet 12(4):376-84. [PubMed: 8630490]  [MGI Ref ID J:32083]

Chang B; Hawes NL; Hurd RE; Wang J; Howell D; Davisson MT; Roderick TH; Nusinowitz S; Heckenlively JR. 2005. Mouse models of ocular diseases. Vis Neurosci 22(5):587-93. [PubMed: 16332269]  [MGI Ref ID J:156373]

Cicero SA; Johnson D; Reyntjens S; Frase S; Connell S; Chow LM; Baker SJ; Sorrentino BP; Dyer MA. 2009. Cells previously identified as retinal stem cells are pigmented ciliary epithelial cells. Proc Natl Acad Sci U S A 106(16):6685-90. [PubMed: 19346468]  [MGI Ref ID J:148343]

Clark AM; Yun S; Veien ES; Wu YY; Chow RL; Dorsky RI; Levine EM. 2008. Negative regulation of Vsx1 by its paralog Chx10/Vsx2 is conserved in the vertebrate retina. Brain Res 1192:99-113. [PubMed: 17919464]  [MGI Ref ID J:131879]

Coles BL; Horsford DJ; McInnes RR; van der Kooy D. 2006. Loss of retinal progenitor cells leads to an increase in the retinal stem cell population in vivo. Eur J Neurosci 23(1):75-82. [PubMed: 16420417]  [MGI Ref ID J:105261]

Dhomen NS; Balaggan KS; Pearson RA; Bainbridge JW; Levine EM; Ali RR; Sowden JC. 2006. Absence of chx10 causes neural progenitors to persist in the adult retina. Invest Ophthalmol Vis Sci 47(1):386-96. [PubMed: 16384989]  [MGI Ref ID J:104265]

Gao L; Miller RH. 2006. Specification of optic nerve oligodendrocyte precursors by retinal ganglion cell axons. J Neurosci 26(29):7619-28. [PubMed: 16855089]  [MGI Ref ID J:110658]

Gouge A; Holt J; Hardy AP; Sowden JC; Smith HK. 2001. Foxn4 - a new member of the forkhead gene family is expressed in the retina. Mech Dev 107(1-2):203-6. [PubMed: 11520680]  [MGI Ref ID J:71345]

Horsford DJ; Nguyen MT; Sellar GC; Kothary R; Arnheiter H; McInnes RR. 2005. Chx10 repression of Mitf is required for the maintenance of mammalian neuroretinal identity. Development 132(1):177-87. [PubMed: 15576400]  [MGI Ref ID J:94374]

Jones BW; Watt CB; Frederick JM; Baehr W; Chen CK; Levine EM; Milam AH; Lavail MM; Marc RE. 2003. Retinal remodeling triggered by photoreceptor degenerations. J Comp Neurol 464(1):1-16. [PubMed: 12866125]  [MGI Ref ID J:84675]

Khachab MY; Bruce LL. 1999. The development of corticocollicular projections in anophthalmic mice. Brain Res Dev Brain Res 114(2):179-92. [PubMed: 10320757]  [MGI Ref ID J:109169]

Khachab MY; Bruce LL. 1999. The maturation of corticocollicular neurons in mice. Brain Res Dev Brain Res 112(1):145-8. [PubMed: 9974169]  [MGI Ref ID J:109173]

Kokkinopoulos I; Pearson RA; Macneil A; Dhomen NS; Maclaren RE; Ali RR; Sowden JC. 2008. Isolation and characterisation of neural progenitor cells from the adult Chx10(orJ/orJ) central neural retina. Mol Cell Neurosci 38(3):359-73. [PubMed: 18514541]  [MGI Ref ID J:137047]

Livne-Bar I; Pacal M; Cheung MC; Hankin M; Trogadis J; Chen D; Dorval KM; Bremner R. 2006. Chx10 is required to block photoreceptor differentiation but is dispensable for progenitor proliferation in the postnatal retina. Proc Natl Acad Sci U S A 103(13):4988-93. [PubMed: 16547132]  [MGI Ref ID J:107659]

Ma C; Papermaster D; Cepko CL. 1998. A unique pattern of photoreceptor degeneration in cyclin D1 mutant mice. Proc Natl Acad Sci U S A 95(17):9938-43. [PubMed: 9707579]  [MGI Ref ID J:49399]

Prochazka M; Leiter EH; Cook S; Davisson MT; Bronson R. 1990. or-2J; a new remutation at ocular retardation (or) associated with sterility Mouse Genome 87:93.  [MGI Ref ID J:30714]

Rhoades RW; Mooney RD; Fish SE. 1984. A comparison of visual callosal organization in normal, bilaterally enucleated and congenitally anophthalmic mice. Exp Brain Res 56(1):92-105. [PubMed: 6468571]  [MGI Ref ID J:45405]

Robb RM; Silver J; Sullivan RT. 1978. Ocular retardation (or) in the mouse. Invest Ophthalmol Vis Sci 17(5):468-73. [PubMed: 640793]  [MGI Ref ID J:5966]

Rowan S; Cepko CL. 2005. A POU factor binding site upstream of the Chx10 homeobox gene is required for Chx10 expression in subsets of retinal progenitor cells and bipolar cells. Dev Biol 281(2):240-55. [PubMed: 15893976]  [MGI Ref ID J:98542]

Rowan S; Cepko CL. 2004. Genetic analysis of the homeodomain transcription factor Chx10 in the retina using a novel multifunctional BAC transgenic mouse reporter. Dev Biol 271(2):388-402. [PubMed: 15223342]  [MGI Ref ID J:91498]

Rowan S; Chen CM; Young TL; Fisher DE; Cepko CL. 2004. Transdifferentiation of the retina into pigmented cells in ocular retardation mice defines a new function of the homeodomain gene Chx10. Development 131(20):5139-52. [PubMed: 15459106]  [MGI Ref ID J:93571]

Rutherford AD; Dhomen N; Smith HK; Sowden JC. 2004. Delayed expression of the Crx gene and photoreceptor development in the Chx10-deficient retina. Invest Ophthalmol Vis Sci 45(2):375-84. [PubMed: 14744875]  [MGI Ref ID J:87739]

Sigulinsky CL; Green ES; Clark AM; Levine EM. 2008. Vsx2/Chx10 ensures the correct timing and magnitude of Hedgehog signaling in the mouse retina. Dev Biol 317(2):560-75. [PubMed: 18417110]  [MGI Ref ID J:135151]

Silver J; Robb RM. 1979. Studies on the development of the eye cup and optic nerve in normal mice and in mutants with congenital optic nerve aplasia. Dev Biol 68(1):175-90. [PubMed: 437315]  [MGI Ref ID J:6121]

Theiler K; Varnum DS; Nadeau JH; Stevens LC; Cagianut B. 1976. A new allele of ocular retardation: early development and morphogenetic cell death. Anat Embryol (Berl) 150(1):85-97. [PubMed: 827941]  [MGI Ref ID J:5767]

Wong G; Conger SB; Burmeister M. 2006. Mapping of genetic modifiers affecting the eye phenotype of ocular retardation (Chx10(or-J)) mice. Mamm Genome 17(6):518-25. [PubMed: 16783634]  [MGI Ref ID J:109796]

Zou C; Levine EM. 2012. Vsx2 controls eye organogenesis and retinal progenitor identity via homeodomain and non-homeodomain residues required for high affinity DNA binding. PLoS Genet 8(9):e1002924. [PubMed: 23028343]  [MGI Ref ID J:190452]

de Melo J; Du G; Fonseca M; Gillespie LA; Turk WJ; Rubenstein JL; Eisenstat DD. 2005. Dlx1 and Dlx2 function is necessary for terminal differentiation and survival of late-born retinal ganglion cells in the developing mouse retina. Development 132(2):311-22. [PubMed: 15604100]  [MGI Ref ID J:95327]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3300.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $4290.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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