Strain Name:

C3Sn.B6-KitW-39J/J

Stock Number:

000847

Availability:

Repository-Cryopreserved

Description

Strain Information

Type Congenic; Mutant Strain;
Additional information on Genetically Engineered Mutant Mice.
Specieslaboratory mouse
Background Strain C3H/HeSnJ
Donor Strain C57BL/6J
GenerationpN2N1

Related Strains

Strains carrying   KitW-39J allele
000062   C57BL/6J-KitW-39J/J
View Strains carrying   KitW-39J     (1 strain)

View Strains carrying other alleles of Kit     (35 strains)

Additional Web Information

Congenic Nomenclature

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms
      assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

KitW-39J/Kit+

        involves: C57BL/6J
  • skin/coat/nails phenotype
  • belly spot (MGI Ref ID J:6571)
    • mice exhibit a large white belly spot
  • diluted coat color (MGI Ref ID J:6571)
    • mice exhibit slight dilution of their dorsal and ventral coats
  • hematopoietic system phenotype
  • macrocytic anemia (MGI Ref ID J:6571)
    • mild, normochromic, macrocytic anemia
  • pigmentation phenotype
  • belly spot (MGI Ref ID J:6571)
    • mice exhibit a large white belly spot
  • diluted coat color (MGI Ref ID J:6571)
    • mice exhibit slight dilution of their dorsal and ventral coats

KitW-39J/KitW-39J

        involves: C57BL/6J
  • lethality-prenatal/perinatal
  • prenatal lethality (MGI Ref ID J:6571)
    • fewer than expected mice are born alive
  • life span-post-weaning/aging
  • decreased survivor rate (MGI Ref ID J:6571)
  • reproductive system phenotype
  • abnormal ovarian follicle number (MGI Ref ID J:6571)
    • ovaries contain fewer developing follicles than in wild-type mice
  • delayed female fertility (MGI Ref ID J:6571)
  • reduced fertility (MGI Ref ID J:6571)
  • small ovary (MGI Ref ID J:6571)
  • small testis (MGI Ref ID J:6571)
  • skin/coat/nails phenotype
  • absent coat pigmentation (MGI Ref ID J:6571)
    • mice are black-eyed with white coats
  • endocrine/exocrine gland phenotype
  • abnormal ovarian follicle number (MGI Ref ID J:6571)
    • ovaries contain fewer developing follicles than in wild-type mice
  • small ovary (MGI Ref ID J:6571)
  • small testis (MGI Ref ID J:6571)
  • pigmentation phenotype
  • absent coat pigmentation (MGI Ref ID J:6571)
    • mice are black-eyed with white coats
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

KitW-39J related

Cancer Research
Growth Factors/Receptors/Cytokines
Increased Tumor Incidence (Gonadal Tumors: ovarian)
Oncogenes

Dermatology Research
Color and White Spotting Defects

Developmental Biology Research
Neural Crest Defects

Endocrine Deficiency Research
Bone/Bone Marrow Defects
Gonad Defects
Skin Defects

Immunology and Inflammation Research
Immunodeficiency (Mast Cell Deficiency)

Mouse/Human Gene Homologs
piebaldism

Neurobiology Research
Receptor Defects
Vestibular and Hearing Defects

Reproductive Biology Research
Developmental Defects Affecting Gonads (germ cell deficient)
Fertility Defects
Gonadal Tumors (ovarian)

Research Tools
Immunology and Inflammation Research (Mast Cell Deficiency)

Sensorineural Research
Vestibular and Hearing Defects

Genes & Alleles

Gene & Allele Information

Allele Symbol KitW-39J
Allele Name dominant spotting 39 Jackson
Allele Type Spontaneous
Strain of OriginC57BL/6J
Gene Symbol and Name Kit, kit oncogene
Chromosome 5
Gene Common Name(s) Bs; C-Kit; CD117; Dominant white spotting; Fdc; Gsfsco1; Gsfsco5; Gsfsow3; PBT; SCFR; SCO1; SCO5; SOW3; Ssm; Steel Factor Receptor; Tr-kit; W; belly-spot; dominant spotting; gsf spotted coat 1; gsf spotted coat 5; phenotype like Sl or W 3; spotted sterile male;
General Note KitW-39J, dominant spotting 39J, semidominant. Homozygotes for this mutation are viable, though anemic and of low fertility (J:6571, J:7186).

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Optimizing PCR Protocols

References

References

Selected Reference(s)

Geissler EN; McFarland EC; Russell ES. 1981. Analysis of pleiotropism at the dominant white-spotting (W) locus of the house mouse: a description of ten new W alleles. Genetics 97(2):337-61. [PubMed: 7274658]  [MGI Ref ID J:6571]

Additional References

KitW-39J related

Geissler EN; Russell ES. 1983. Analysis of the hematopoietic effects of new dominant spotting (W) mutations of the mouse. I. Influence upon hematopoietic stem cells. Exp Hematol 11(6):452-60. [PubMed: 6352297]  [MGI Ref ID J:7186]

Health & husbandry

Health & Colony Maintenance Information

Currently there no information available for this strain. This may be due to the supply level of this strain.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations View International pricing
Price*
Cryorecovery Fee $1900.00
*Price(s) in US dollars ($)

Additional Supply Details

Pricing for International shipping destinations View USA Canada and Mexico pricing
Price*
Cryorecovery Fee $2470.00
*Price(s) in US dollars ($)

Additional Supply Details

Supply Details

Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes
  • Cryorecovery - Standard.
    At least two mice that carry the mutation (if it is a mutant strain) will be provided. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotypes and genders are needed. IMPORTANT NOTE: The genotypes of the animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire for possible genotypes for this specific strain. Animals typically ship within 13 to 16 weeks from your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will typically ship within 25 weeks.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 or 1-207-288-5845.

  • Genomic DNA is available for this strain from the Mouse DNA Resource.

General Terms and Conditions


See Terms of Use


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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Contact Information
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Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
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Terms of Use

Terms of Use


General Terms and Conditions


Contact information

General inquiries

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phone:207-288-6470
fax:207-288-6655

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