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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Former Names In30Rk (Changed: 15-DEC-04 ) Type Chromosome Aberration; Inversion; Additional information on Mice with Chromosomal Aberrations. Type Mutant Stock; Additional information on Genetically Engineered Mutant Mice. Species laboratory mouse Appearance
black, retinal degeneration
Related Genotype: a/a rd3/rd3Important Note
This strain is homozygous for retinal degeneration 3, rd3.
Related Strains
Inversions
View Inversions (48 strains)
000726 RBF/DnJ 000807 RBJ/DnJ 000729 STOCK Rb(11.13)4Bnr/J
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
In(5)30Rk/+
involves: M. m. domesticus poschiavinus
- reproductive system phenotype
- abnormal male meiosis (MGI Ref ID J:23389)
- male heterozygotes have an anaphase bridge frequency of approximately 27%
This mouse can be used to support research in many areas including:
Sensorineural Research
Retinal Degeneration (rd3)
Genes & Alleles
Gene & Allele Information
| Allele Symbol | In(5)30Rk | ||
|---|---|---|---|
| Allele Name | inversion, Chr 5, Roderick 30 | ||
| Allele Type | Chemically induced (other) | ||
| Common Name(s) | In30Rk; | ||
| Strain of Origin | M. m. domesticus poschiavinus | ||
| Molecular Note | this inversion was induced with triethylene melamine and the breakpoints are in 5A2 and 5E2 [MGI Ref ID J:23389] | ||
| Allele Symbol | Rd3rd3 | ||
| Allele Name | retinal degeneration 3 | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | RBF/DnJ | ||
| Gene Symbol and Name | Rd3, retinal degeneration 3 | ||
| Chromosome | 1 | ||
| Gene Common Name(s) | 3322402L07Rik; C1orf36; LCA12; RIKEN cDNA 3322402L07 gene; rd-3; | ||
| General Note | This mutation causes retinal degeneration. In homozygous mutant mice, development proceeds normally through the second postnatal week. Thereafter, photoreceptor and outer nuclear layers begin to degenerate, and by 8 weeks, no photoreceptor cells remain. Changes in electroretinograms parallel the histologic changes. As of 1998 this is the only type of retinal degeneration reported in mice in which the photoreceptors are initially normal (J:4367). | ||
| Molecular Note | A C to T substitution in Rd3 results in a stop codon after residue 106. The truncated protein is initially expressed in in vitro assays but is degraded. [MGI Ref ID J:122439] | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Optimizing PCR Protocols
References
References
Selected Reference(s)
Roderick TH. 1983. Using inversions to detect and study recessive lethals and detrimentals in mice. In: Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk. Plenum Publishing Corp.. [MGI Ref ID J:23389]
Additional References
Chang B; Hawes NL; Hurd RE; Davisson MT; Nusinowitz S; Heckenlively JR. 2002. Retinal degeneration mutants in the mouse. Vision Res 42(4):517-25. [PubMed: 11853768] [MGI Ref ID J:75095]
Lyon MF; Rastan S; Brown SDM. 1996. . In: Genetic Variants and Strains of the Laboratory Mouse. Oxford University Press, Oxford. [MGI Ref ID J:43743]
Rd3rd3 relatedIn(5)30Rk relatedChang B; Hawes NL; Hurd RE; Davisson MT; Nusinowitz S; Heckenlively JR. 2002. Retinal degeneration mutants in the mouse. Vision Res 42(4):517-25. [PubMed: 11853768] [MGI Ref ID J:75095]
Chang B; Heckenlively JR; Hawes NL; Roderick TH. 1993. New mouse primary retinal degeneration (rd-3). Genomics 16(1):45-9. [PubMed: 8486383] [MGI Ref ID J:4367]
Danciger M; Ogando D; Yang H; Matthes MT; Yu N; Ahern K; Yasumura D; Williams RW; Lavail MM. 2008. Genetic modifiers of retinal degeneration in the rd3 mouse. Invest Ophthalmol Vis Sci 49(7):2863-9. [PubMed: 18344445] [MGI Ref ID J:136923]
Friedman JS; Chang B; Kannabiran C; Chakarova C; Singh HP; Jalali S; Hawes NL; Branham K; Othman M; Filippova E; Thompson DA; Webster AR; Andreasson S; Jacobson SG; Bhattacharya SS; Heckenlively JR; Swaroop A. 2006. Premature truncation of a novel protein, RD3, exhibiting subnuclear localization is associated with retinal degeneration. Am J Hum Genet 79(6):1059-70. [PubMed: 17186464] [MGI Ref ID J:122439]
Hawes NL; Smith RS; Chang B; Davisson M; Heckenlively JR; John SW. 1999. Mouse fundus photography and angiography: a catalogue of normal and mutant phenotypes. Mol Vis 5:22. [PubMed: 10493779] [MGI Ref ID J:59481]
Heckenlively JR; Chang B; Erway LC; Peng C; Hawes NL; Hageman GS; Roderick TH. 1995. Mouse model for Usher syndrome: linkage mapping suggests homology to Usher type I reported at human chromosome 11p15. Proc Natl Acad Sci U S A 92(24):11100-4. [PubMed: 7479945] [MGI Ref ID J:121993]
Pieke-Dahl S; Ohlemiller KK; McGee J; Walsh EJ; Kimberling WJ. 1997. Hearing loss in the RBF/DnJ mouse, a proposed animal model of Usher syndrome type IIa. Hear Res 112(1-2):1-12. [PubMed: 9367224] [MGI Ref ID J:44148]
Lyon MF; Rastan S; Brown SDM. 1996. . In: Genetic Variants and Strains of the Laboratory Mouse. Oxford University Press, Oxford. [MGI Ref ID J:43743]
Health & husbandry
Health & Colony Maintenance Information
Currently there no information available for this strain. This may be due to the supply level of this strain.
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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*Price(s) in US dollars ($)
Price* Cryorecovery Fee $1900.00
Additional Supply Details
| Pricing for International shipping destinations |
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*Price(s) in US dollars ($)
Price* Cryorecovery Fee $2470.00
Additional Supply Details
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
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| Supply Notes |
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| Important Note | This strain is homozygous for retinal degeneration 3, rd3. |
General Terms and Conditions
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