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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Type Congenic; Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Homozygote x Homozygote (Female x Male) 01-MAR-06 Species laboratory mouse Background Strain BALB/c Donor Strain C57BL/6 Generation N11F88 (12-NOV-10)
Generation DefinitionsAppearance
agouti brown (yellowish cinnamon)
Related Genotype: A/A Tyrp1b/Tyrp1b Tyr+ /+ Tyr+
Control Information
| Control | ||
|---|---|---|
| 000651 BALB/cJ | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Hbbs allele
000562 B6(Cg)-Tubtub/J View Strains carrying Hbbs (1 strain)
000090 129S1/Sv-Oca2+ Tyr+ KitlSl-J/J 005445 A.B6 Tyr+-Cybanmf333/J 005012 A.B6 Tyr+-Myo5ad-l31J/J 002565 A.B6-Tyr+/J 000822 B6 x 129S1/SvEi Oca2+ Tyr+-Vsx2or-J/J 000494 J.Cg-Oca2+ Tyr+ Lystbg/J 002281 NFS.C58-Tyr+/J 004304 NOD.CBALs-Tyr+/LtJ
000409 B10.129P-H1b Hbbd Tyrc Ea7a/(5M)oSnJ 000418 B10.129P-H1b Tyrc Hbbd/(5M)nSnJ 000432 B10.C-H1b Hbbd Tyrc/(41N)SnJ 000562 B6(Cg)-Tubtub/J 002204 B6.129P2-Hbbtm1Unc/J 000383 B6.C-Tyrc H1b Hbbd/ByJ 002074 B6.Cg-Gpi1a Hbbd H1b/DehJ 000996 B6.D2-Hbbd3th/BrkJ 013071 B6;129-Hbatm1(HBA)Tow Hbbtm2(HBG1,HBB*)Tow/Hbbtm3(HBG1,HBB)Tow/J 003250 B6;129P2-Hbbtm2Unc/J 000758 C57BL/6J-Hbbp Hrrh-7J/J 003342 STOCK Hbatm1Paz Hbbtm1Tow Tg(HBA-HBBs)41Paz/J
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Hbbs/Hbbs
C57BL/6
- normal phenotype
- no abnormal phenotype detected (MGI Ref ID J:118857)
This mouse can be used to support research in many areas including:Hbbs related
Tyr+ relatedHematological Research
Hemoglobin Defects
Mouse/Human Gene Homologs
thalassemia, beta
Dermatology Research
Color and White Spotting Defects
oculocutaneous albinism, type I
Mouse/Human Gene Homologs
albinism, tyrosine negative
wildtype
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Hbbs | ||
|---|---|---|---|
| Allele Name | single | ||
| Allele Type | Not Applicable | ||
| Strain of Origin | C57BL/6 | ||
| Gene Symbol and Name | Hbb, hemoglobin beta chain complex | ||
| Chromosome | 7 | ||
| Gene Common Name(s) | CD113t-C; beta-globin; | ||
| Molecular Note | This natural variant identified by protein sequencing, produces a single beta globin with one reactive cysteine (betaCyst13). Two structurally identical beta globins migrate during electrophoresis in a dimer with alpha globin as a single band, therefore the s designation. [MGI Ref ID J:118857] | ||
| Allele Symbol | Tyr+ | ||
| Allele Name | wild type | ||
| Allele Type | Not Applicable | ||
| Gene Symbol and Name | Tyr, tyrosinase | ||
| Chromosome | 7 | ||
| Gene Common Name(s) | C; CMM8; OCA1A; OCAIA; SHEP3; albino; c; skc35; skin/coat color 35; | ||
References
References provided by MGI
Additional References
Hbbs relatedTyr+ relatedHempe JM; Ory-Ascani J; Hsia D. 2007. Genetic variation in mouse beta globin cysteine content modifies glutathione metabolism: implications for the use of mouse models. Exp Biol Med (Maywood) 232(3):437-44. [PubMed: 17327478] [MGI Ref ID J:118857]
Leder A; Wiener E; Lee MJ; Wickramasinghe SN; Leder P. 1999. A normal beta-globin allele as a modifier gene ameliorating the severity of alpha-thalassemia in mice. Proc Natl Acad Sci U S A 96(11):6291-5. [PubMed: 10339580] [MGI Ref ID J:55195]
Lyon MF; Barker JE; Popp RA. 1988. Mouse globin gene nomenclature. J Hered 79(2):93-5. [PubMed: 3403963] [MGI Ref ID J:9288]
Szuber N; Buss JL; Soe-Lin S; Felfly H; Trudel M; Ponka P. 2008. Alternative treatment paradigm for thalassemia using iron chelators. Exp Hematol 36(7):773-85. [PubMed: 18456387] [MGI Ref ID J:136991]
Erickson RP; Gluecksohn-Waelsch S; Cori CF. 1968. Glucose-6-phosphatase deficiency caused by radiation-induced alleles at the albino locus in the mouse. Proc Natl Acad Sci U S A 59(2):437-44. [PubMed: 4296364] [MGI Ref ID J:5063]
Lossie AC; Nakamura H; Thomas SE; Justice MJ. 2005. Mutation of l7Rn3 shows that Odz4 is required for mouse gastrulation. Genetics 169(1):285-99. [PubMed: 15489520] [MGI Ref ID J:96673]
Miller DA; Dev VG; Tantravahi R; Miller OJ; Schiffman MB; Yates RA; Gluecksohn-Waelsch S. 1974. Cytological detection of the c-25H deletion involving the albino (c) locus on chromosome 7 in the mouse. Genetics 78(3):905-10. [PubMed: 4141683] [MGI Ref ID J:5520]
Oak Ridge National Laboratory. 2005. Information obtained from the Oak Ridge National Laboratory Mutant Mouse Database (ORNL), Oak Ridge, TN Unpublished :. [MGI Ref ID J:100221]
Sweet HO. 1987. Acromelanic (c<a>) Mouse News Lett 78:56. [MGI Ref ID J:14994]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number A1
Colony Maintenance
Mating System Homozygote x Homozygote (Female x Male) 01-MAR-06
Purchasing information
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Live Mice
Price (US dollars $) Gender Genotypes Provided Individual Mouse $110.00 Female or Male Homozygous for Tyr+, Homozygous for Hbbs
Pairs /Price (US dollars $) Pair Genotype $220.00 Homozygous for Tyr+, Homozygous for Hbbs x Homozygous for Tyr+, Homozygous for Hbbs Standard Supply
Repository-Live. The Repository Strains represent an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. We treat orders for these strains as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
| Pricing for International shipping destinations |
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Live Mice
Price (US dollars $) Gender Genotypes Provided Individual Mouse $143.00 Female or Male Homozygous for Tyr+, Homozygous for Hbbs
Pairs /Price (US dollars $) Pair Genotype $286.00 Homozygous for Tyr+, Homozygous for Hbbs x Homozygous for Tyr+, Homozygous for Hbbs Standard Supply
Repository-Live. The Repository Strains represent an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. We treat orders for these strains as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
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|
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Standard Supply
Repository-Live. The Repository Strains represent an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. We treat orders for these strains as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
General Supply Notes
- This strain is included in the Mouse Mutant Resource collection.
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| 000651 BALB/cJ | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
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