JAX Mice Database - 000899 C.B6-Tyr<+> Hbb<s>/J

Strain Name:	C.B6-Tyr⁺ Hbb^s/J
Stock Number:	000899
Availability:	Repository- Live

Description
Phenotype
Genes & alleles
Genotyping
Health & husbandry
References
Purchasing information
Terms of Use

Description

Strain Information

Type Congenic; Mutant Strain;
Additional information on Genetically Engineered and Mutant Mice.

Visit our online Nomenclature tutorial.

Additional information on Congenic nomenclature.

Mating System Homozygote x Homozygote (Female x Male) 01-MAR-06

Species laboratory mouse

Background Strain BALB/c

Donor Strain C57BL/6

Generation N11F86 (05-NOV-09)

Appearance
agouti brown (yellowish cinnamon)
Related Genotype: A/A Tyrp1^b/Tyrp1^b Tyr⁺ /+ Tyr⁺

Control Information

	Control
	000651 BALB/cJ

Considerations for Choosing Controls

Related Strains

Strains carrying Hbb^s allele

000562 B6(Cg)-Tub^tub/J

View Strains carrying Hbb^s (1 strain)

Strains carrying Tyr⁺ allele

000090 129S1/Sv-Oca2⁺ Tyr⁺ Kitl^Sl-J/J

005445 A.B6 Tyr⁺-Cyba^nmf333/J

005012 A.B6 Tyr⁺-Myo5a^d-l31J/J

002565 A.B6-Tyr⁺/J

000822 B6 x 129S1/SvEi Oca2⁺ Tyr⁺-Vsx2^or-J/J

000494 J.Cg-Oca2⁺ Tyr⁺ Lyst^bg/J

002281 NFS.C58-Tyr⁺/J

004304 NOD.CBALs-Tyr⁺/LtJ

View Strains carrying Tyr⁺ (8 strains)

Strains carrying other alleles of Hbb

000409 B10.129P-H1^b Hbb^d Tyr^c Ea7^a/(5M)oSnJ

000418 B10.129P-H1^b Tyr^c Hbb^d/(5M)nSnJ

000432 B10.C-H1^b Hbb^d Tyr^c/(41N)SnJ

002204 B6.129P2-Hbb^tm1Unc/J

000383 B6.C-Tyr^c H1^b Hbb^d/ByJ

002074 B6.Cg-Gpi1^a Hbb^d H1^b/DehJ

003250 B6;129P2-Hbb^tm2Unc/J

000996 C57BL/6J-Hbb^d3th/J

000758 C57BL/6J-Hbb^p Hr^rh-7J/J

003342 STOCK Hba^tm1Paz Hbb^tm1Tow Tg(HBA-HBBs)41Paz/J

View Strains carrying other alleles of Hbb (10 strains)

Strains carrying other alleles of Tyr

000091 129T1/Sv-Oca2⁺ Tyr^c-ch Dnd1^Ter/J

001279 129T1/Sv-Oca2⁺ Tyr^c-ch-Aft/J

001017 AKXD10/TyJ

000765 AKXD13/TyJ

000954 AKXD15/TyJ

000958 AKXD16/TyJ

001093 AKXD18/TyJ

001062 AKXD21/TyJ

000947 AKXD22/TyJ

000969 AKXD24/TyJ

000777 AKXD6/TyJ

000763 AKXD9/TyJ

000409 B10.129P-H1^b Hbb^d Tyr^c Ea7^a/(5M)oSnJ

000418 B10.129P-H1^b Tyr^c Hbb^d/(5M)nSnJ

000432 B10.C-H1^b Hbb^d Tyr^c/(41N)SnJ

000580 B10.D2/nSn-Tyr^c-4J/J

000578 B6 x STOCK Tyr^c-ch Bmp5^se +/+ Myo6^sv/J

000058 B6(Cg)-Tyr^c-2J/J

000383 B6.C-Tyr^c H1^b Hbb^d/ByJ

007484 B6.Cg-Tyr^c-2J Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ

000035 B6.Cg-Tyr^c-J/J

000104 B6.Cg-Tyr^c-h/J

000054 B6.D2-Tyr^c-p/J

000339 C3H/HeJ-Tyr^c-9J/J

001294 C3H/HeJ-Tyr^c-a/J

001002 C57BL/10SnJ-Tyr^c-11J/J

001006 CBA/J-Tyr^c-10J/J

000657 CE/J

000619 FS/EiJ

004828 FVB.129P2-Pde6b⁺ Tyr^c-ch/AntJ

007483 FVB.Cg-Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ

005115 NOD.FVB-Tg(INS-MT2A,Tyr)1Pne/PneJ

005114 NOD.FVB-Tg(Ins1-Cat,Tyr)25Pne/PneJ

000271 SH1/LeJ

001759 STOCK A Tyr^c Sha/J

000306 STOCK Dll3^pu + Tyr^c-ch/+ Oca2^p Tyr^c-ch/J

000006 STOCK Hk Tyr^c/J

000206 STOCK a/a Tyr^c-h/J

View Strains carrying other alleles of Tyr (38 strains)

Phenotype

Phenotype Information

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:
Hbb^s related

Hematological Research
Hemoglobin Defects

Mouse/Human Gene Homologs
thalassemia, beta

Tyr⁺ related

Dermatology Research
Color and White Spotting Defects
oculocutaneous albinism, type I

Mouse/Human Gene Homologs
albinism, tyrosine negative
wildtype

Genes & Alleles

Gene & Allele Information


Allele Symbol		Hbb^s
Allele Name		s
Allele Type		Chemically induced (ENU)
Strain of Origin		C57BL/6
Gene Symbol and Name		Hbb, hemoglobin beta chain complex
Chromosome		7
Gene Common Name(s)		CD113t-C; beta-globin;

Allele Symbol		Tyr⁺
Allele Name		wild type
Allele Type		Not Applicable
Gene Symbol and Name		Tyr, tyrosinase
Chromosome		7
Gene Common Name(s)		OCA1A; OCAIA; SHEP3; albino; c; skc35; skin/coat color 35;

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Genotyping resources and troubleshooting

References

Additional References

Hbb^s related

Hempe JM; Ory-Ascani J; Hsia D. 2007. Genetic variation in mouse beta globin cysteine content modifies glutathione metabolism: implications for the use of mouse models. Exp Biol Med (Maywood) 232(3):437-44. [PubMed: 17327478] [MGI Ref ID J:118857]

Lyon MF; Barker JE; Popp RA. 1988. Mouse globin gene nomenclature. J Hered 79(2):93-5. [PubMed: 3403963] [MGI Ref ID J:9288]

Szuber N; Buss JL; Soe-Lin S; Felfly H; Trudel M; Ponka P. 2008. Alternative treatment paradigm for thalassemia using iron chelators. Exp Hematol 36(7):773-85. [PubMed: 18456387] [MGI Ref ID J:136991]

Tyr⁺ related

Lossie AC; Nakamura H; Thomas SE; Justice MJ. 2005. Mutation of l7Rn3 shows that Odz4 is required for mouse gastrulation. Genetics 169(1):285-99. [PubMed: 15489520] [MGI Ref ID J:96673]

Miller DA; Dev VG; Tantravahi R; Miller OJ; Schiffman MB; Yates RA; Gluecksohn-Waelsch S. 1974. Cytological detection of the c-25H deletion involving the albino (c) locus on chromosome 7 in the mouse. Genetics 78(3):905-10. [PubMed: 4141683] [MGI Ref ID J:5520]

Sweet HO. 1987. Acromelanic (c<a>) Mouse News Lett 78:56. [MGI Ref ID J:14994]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports
Room Number A1

Colony Maintenance

Mating System Homozygote x Homozygote (Female x Male) 01-MAR-06

Mating System	Homozygote x Homozygote (Female x Male) 01-MAR-06

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations

Weeks of Age Price (US dollars $) Gender Genotypes Provided

Individual Mouse $97.10 Female or Male Homozygous for Tyr⁺, Homozygous for Hbb^s

Pairs /Price (US dollars $) Pair Genotype

$194.20 Homozygous for Tyr⁺, Homozygous for Hbb^s x Homozygous for Tyr⁺, Homozygous for Hbb^s

Weeks of Age	Price (US dollars $)	Gender	Genotypes Provided
Individual Mouse	$97.10	Female or Male	Homozygous for Tyr⁺, Homozygous for Hbb^s

Pairs /Price (US dollars $)	Pair Genotype
$194.20	Homozygous for Tyr⁺, Homozygous for Hbb^s x Homozygous for Tyr⁺, Homozygous for Hbb^s

Additional Supply Details

Pricing for International shipping destinations

Weeks of Age Price (US dollars $) Gender Genotypes Provided

Individual Mouse $126.30 Female or Male Homozygous for Tyr⁺, Homozygous for Hbb^s

Pairs /Price (US dollars $) Pair Genotype

$252.50 Homozygous for Tyr⁺, Homozygous for Hbb^s x Homozygous for Tyr⁺, Homozygous for Hbb^s

Weeks of Age	Price (US dollars $)	Gender	Genotypes Provided
Individual Mouse	$126.30	Female or Male	Homozygous for Tyr⁺, Homozygous for Hbb^s

Pairs /Price (US dollars $)	Pair Genotype
$252.50	Homozygous for Tyr⁺, Homozygous for Hbb^s x Homozygous for Tyr⁺, Homozygous for Hbb^s

Additional Supply Details

Supply Details

Standard Supply	Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement.
Supply Notes	Usually shipped between four and eight weeks of age. This strain is included in the Mouse Mutant Resource collection. Genomic DNA is available for this strain from the Mouse DNA Resource.

Standard Supply

Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement.

Supply Notes

Usually shipped between four and eight weeks of age.
This strain is included in the Mouse Mutant Resource collection.
Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

	Control
	000651 BALB/cJ

Considerations for Choosing Controls
USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
International - Control Pricing Information for Genetically Engineered Mutant Strains.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

Ordering and Purchasing Information

Purchasing Information
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Contact Information
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Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

General Terms and Conditions

Contact information

General inquiries

Contracts Administration

phone:	207-288-6470
fax:	207-288-6655

JAX^® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

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MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.

000090	129S1/Sv-Oca2⁺ Tyr⁺ Kitl^Sl-J/J
005445	A.B6 Tyr⁺-Cyba^nmf333/J
005012	A.B6 Tyr⁺-Myo5a^d-l31J/J
002565	A.B6-Tyr⁺/J
000822	B6 x 129S1/SvEi Oca2⁺ Tyr⁺-Vsx2^or-J/J
000494	J.Cg-Oca2⁺ Tyr⁺ Lyst^bg/J
002281	NFS.C58-Tyr⁺/J
004304	NOD.CBALs-Tyr⁺/LtJ

000409	B10.129P-H1^b Hbb^d Tyr^c Ea7^a/(5M)oSnJ
000418	B10.129P-H1^b Tyr^c Hbb^d/(5M)nSnJ
000432	B10.C-H1^b Hbb^d Tyr^c/(41N)SnJ
002204	B6.129P2-Hbb^tm1Unc/J
000383	B6.C-Tyr^c H1^b Hbb^d/ByJ
002074	B6.Cg-Gpi1^a Hbb^d H1^b/DehJ
003250	B6;129P2-Hbb^tm2Unc/J
000996	C57BL/6J-Hbb^d3th/J
000758	C57BL/6J-Hbb^p Hr^rh-7J/J
003342	STOCK Hba^tm1Paz Hbb^tm1Tow Tg(HBA-HBBs)41Paz/J

000091	129T1/Sv-Oca2⁺ Tyr^c-ch Dnd1^Ter/J
001279	129T1/Sv-Oca2⁺ Tyr^c-ch-Aft/J
001017	AKXD10/TyJ
000765	AKXD13/TyJ
000954	AKXD15/TyJ
000958	AKXD16/TyJ
001093	AKXD18/TyJ
001062	AKXD21/TyJ
000947	AKXD22/TyJ
000969	AKXD24/TyJ
000777	AKXD6/TyJ
000763	AKXD9/TyJ
000409	B10.129P-H1^b Hbb^d Tyr^c Ea7^a/(5M)oSnJ
000418	B10.129P-H1^b Tyr^c Hbb^d/(5M)nSnJ
000432	B10.C-H1^b Hbb^d Tyr^c/(41N)SnJ
000580	B10.D2/nSn-Tyr^c-4J/J
000578	B6 x STOCK Tyr^c-ch Bmp5^se +/+ Myo6^sv/J
000058	B6(Cg)-Tyr^c-2J/J
000383	B6.C-Tyr^c H1^b Hbb^d/ByJ
007484	B6.Cg-Tyr^c-2J Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
000035	B6.Cg-Tyr^c-J/J
000104	B6.Cg-Tyr^c-h/J
000054	B6.D2-Tyr^c-p/J
000339	C3H/HeJ-Tyr^c-9J/J
001294	C3H/HeJ-Tyr^c-a/J
001002	C57BL/10SnJ-Tyr^c-11J/J
001006	CBA/J-Tyr^c-10J/J
000657	CE/J
000619	FS/EiJ
004828	FVB.129P2-Pde6b⁺ Tyr^c-ch/AntJ
007483	FVB.Cg-Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
005115	NOD.FVB-Tg(INS-MT2A,Tyr)1Pne/PneJ
005114	NOD.FVB-Tg(Ins1-Cat,Tyr)25Pne/PneJ
000271	SH1/LeJ
001759	STOCK A Tyr^c Sha/J
000306	STOCK Dll3^pu + Tyr^c-ch/+ Oca2^p Tyr^c-ch/J
000006	STOCK Hk Tyr^c/J
000206	STOCK a/a Tyr^c-h/J

Strain Name:

C.B6-Tyr+ Hbbs/J

Stock Number:

000899

Availability:

Repository- Live

Strain Information

Control Information

Related Strains

Phenotype Information

Gene & Allele Information

Genotyping Information

Helpful Links

References

Additional References

Health & Colony Maintenance Information

Animal Health Reports

Colony Maintenance

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Additional Supply Details

Additional Supply Details

Supply Details

Control Information

Payment Terms and Conditions

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms of Use

Contact information

Contracts Administration

JAX® Mice, Products & Services Conditions of Use

No Warranty

No Liability

C.B6-Tyr⁺ Hbb^s/J

JAX^® Mice, Products & Services Conditions of Use