Strain Name:

C.B6-Tyr+ Hbbs/J

Stock Number:

000899

Availability:

Repository- Live

Description

Strain Information

Type Congenic; Mutant Strain;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06
Specieslaboratory mouse
Background Strain BALB/c
Donor Strain C57BL/6
GenerationN11F86 (05-NOV-09)

Appearance
agouti brown (yellowish cinnamon)
Related Genotype: A/A Tyrp1b/Tyrp1b Tyr+ /+ Tyr+

Control Information

  Control
   000651 BALB/cJ
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Hbbs allele
000562   B6(Cg)-Tubtub/J
View Strains carrying   Hbbs     (1 strain)

Strains carrying   Tyr+ allele
000090   129S1/Sv-Oca2+ Tyr+ KitlSl-J/J
005445   A.B6 Tyr+-Cybanmf333/J
005012   A.B6 Tyr+-Myo5ad-l31J/J
002565   A.B6-Tyr+/J
000822   B6 x 129S1/SvEi Oca2+ Tyr+-Vsx2or-J/J
000494   J.Cg-Oca2+ Tyr+ Lystbg/J
002281   NFS.C58-Tyr+/J
004304   NOD.CBALs-Tyr+/LtJ
View Strains carrying   Tyr+     (8 strains)

View Strains carrying other alleles of Hbb     (10 strains)

View Strains carrying other alleles of Tyr     (38 strains)

Phenotype

Phenotype Information

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Hbbs related

Hematological Research
Hemoglobin Defects

Mouse/Human Gene Homologs
thalassemia, beta

Tyr+ related

Dermatology Research
Color and White Spotting Defects
      oculocutaneous albinism, type I

Mouse/Human Gene Homologs
albinism, tyrosine negative
      wildtype

Genes & Alleles

Gene & Allele Information

 
Allele Symbol Hbbs
Allele Name s
Allele Type Chemically induced (ENU)
Strain of OriginC57BL/6
Gene Symbol and Name Hbb, hemoglobin beta chain complex
Chromosome 7
Gene Common Name(s) CD113t-C; beta-globin;
 
Allele Symbol Tyr+
Allele Name wild type
Allele Type Not Applicable
Gene Symbol and Name Tyr, tyrosinase
Chromosome 7
Gene Common Name(s) OCA1A; OCAIA; SHEP3; albino; c; skc35; skin/coat color 35;

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Genotyping resources and troubleshooting

References

References

Additional References

Hbbs related

Hempe JM; Ory-Ascani J; Hsia D. 2007. Genetic variation in mouse beta globin cysteine content modifies glutathione metabolism: implications for the use of mouse models. Exp Biol Med (Maywood) 232(3):437-44. [PubMed: 17327478]  [MGI Ref ID J:118857]

Lyon MF; Barker JE; Popp RA. 1988. Mouse globin gene nomenclature. J Hered 79(2):93-5. [PubMed: 3403963]  [MGI Ref ID J:9288]

Szuber N; Buss JL; Soe-Lin S; Felfly H; Trudel M; Ponka P. 2008. Alternative treatment paradigm for thalassemia using iron chelators. Exp Hematol 36(7):773-85. [PubMed: 18456387]  [MGI Ref ID J:136991]

Tyr+ related

Lossie AC; Nakamura H; Thomas SE; Justice MJ. 2005. Mutation of l7Rn3 shows that Odz4 is required for mouse gastrulation. Genetics 169(1):285-99. [PubMed: 15489520]  [MGI Ref ID J:96673]

Miller DA; Dev VG; Tantravahi R; Miller OJ; Schiffman MB; Yates RA; Gluecksohn-Waelsch S. 1974. Cytological detection of the c-25H deletion involving the albino (c) locus on chromosome 7 in the mouse. Genetics 78(3):905-10. [PubMed: 4141683]  [MGI Ref ID J:5520]

Sweet HO. 1987. Acromelanic (c<a>) Mouse News Lett 78:56.  [MGI Ref ID J:14994]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           A1

Colony Maintenance

Mating SystemHomozygote x Homozygote         (Female x Male)   01-MAR-06

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations View International pricing
Weeks of AgePrice (US dollars $)GenderGenotypes Provided
Individual Mouse $97.10Female or MaleHomozygous for Tyr+, Homozygous for Hbbs
Pairs /Price (US dollars $)Pair Genotype
$194.20Homozygous for Tyr+, Homozygous for Hbbs x Homozygous for Tyr+, Homozygous for Hbbs

Additional Supply Details

Pricing for International shipping destinations View USA Canada and Mexico pricing
Weeks of AgePrice (US dollars $)GenderGenotypes Provided
Individual Mouse $126.30Female or MaleHomozygous for Tyr+, Homozygous for Hbbs
Pairs /Price (US dollars $)Pair Genotype
$252.50Homozygous for Tyr+, Homozygous for Hbbs x Homozygous for Tyr+, Homozygous for Hbbs

Additional Supply Details

Supply Details

Standard SupplyRepository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement.
Supply Notes

Control Information

  Control
   000651 BALB/cJ
 
  Considerations for Choosing Controls
  USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
  International - Control Pricing Information for Genetically Engineered Mutant Strains.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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