Description

Strain Information

Type Inbred Strain; Additional information on Inbred Strains. Visit our online Nomenclature tutorial. Mating System Sibling x Sibling         (Female x Male)   01-MAR-06 Species laboratory mouse H2 Haplotype b Generation F195+F6p+F7 (30-NOV-12) Generation Definitions

Appearance
black
Related Genotype: a/a

Description
The Eicher (Ei) C57BL/6 subline was separated from the parental C57BL/6J in 1976 and has been maintained as a separate subline since. C57BL/6 is the most widely used inbred strain. It is commonly used as a general purpose strain and background strain for the generation of congenics carrying both spontaneous and induced mutations. Although this strain is refractory to many tumors, it is a permissive background for maximal expression of most mutations. C57BL/6J mice are used in a wide variety of research areas including cardiovascular biology, developmental biology, diabetes and obesity, genetics, immunology, neurobiology, and sensorineural research. C57BL/6J mice are also commonly used in the production of transgenic mice. Overall, C57BL/6 mice breed well, are long-lived, and have a low susceptibility to tumors.

This subline differs from C57BL/6J at one known locus, although there may be others that have not been identifed. C57BL/6JEiJ does not have a spontaneous deletion in nicotinamide nucleotide transhydrogenase (Nnt).

Development
The Eicher subline separated from the parental C57BL/6J in 1976 when that inbred was at generation F129. It has been maintained as a separately inbreeding subline ever since. In 2006 this strain reached generation F129+72.

Related Strains

C57BL Strains

000665	C57BL/10J
003752	C57BL/10ScNJ
000476	C57BL/10ScSnJ
000666	C57BL/10SnJ
001822	C57BL/10SxJ
001197	C57BL/10WtRkJ
000663	C57BL/6By
001139	C57BL/6ByJ
009123	C57BL/6HaJ
000664	C57BL/6J
005304	C57BL/6NJ

View C57BL Strains     (11 strains)

Additional Web Information

JAX^® NOTES, Winter 2008; 512. New resource illustrates divergence of C57BL/6 laboratory mouse substrains.

Phenotype

Phenotype Information

View Phenotypic Data

Phenotypic Data

Mouse Phenome Database
Festing Inbred Strain Characteristics: C57BL

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Research Tools
General Purpose

Genes & Alleles

Gene & Allele Information provided by MGI

Currently there are no related genes or alleles for this strain.

Genotyping

Genotyping Information

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11. [PubMed: 15081119]  [MGI Ref ID J:89298]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX12

Colony Maintenance

Mating System	Sibling x Sibling         (Female x Male)   01-MAR-06
Diet Information	LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

General Supply Notes

• View the complete collection of spontaneous mutants in the Mouse Mutant Resource.
• Genomic DNA is available for this strain from the Mouse DNA Resource.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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