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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Type Inbred Strain; Additional information on Inbred Strains. Type Wild-Derived; Additional information on Wild-Derived Mice. Mating System Sibling x Sibling (Female x Male) Species M. m. domesticus (Peru) H2 Haplotype k Generation F101 (23-JAN-08) Geographic Origin Rimac Valley, Peru Appearance
agouti
Related Genotype: A/ADevelopment
In 1961, founders were trapped for ME Wallace, University of Cambridge, by O Atteck in a Peruvian Yard that was used to dry maize cobs in Nana Village, Rimac Valley, Peru. These mice were held in a small, closed colony by Wallace. In 1971, at approximately F25, members of this colony were sent to EM Eicher and TH Roderick at The Jackson Laboratory where inbreeding continued. In 2003 this inbred strain reached F88.
Additional Web Information
JAX® NOTES, Winter 1995; 460. Wild-Derived Mice Strains - Tips on Their Care and Handling.
Phenotype
Phenotype Information
View Phenotypic Data
Phenotypic Data
Mouse Phenome Database
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Lith9PERA/EiJ/Lith9PERA/EiJ
involves: I/LnJ * PERA/EiJ
- liver/biliary system phenotype
- gallstones (MGI Ref ID J:84582)
- increased gallstone score
Lith9PERA/EiJ/?
involves: I/LnJ * PERA/EiJ
- liver/biliary system phenotype
- gallstones (MGI Ref ID J:97424)
- susceptibility to gallstone formation
The following phenotype relates to a compound genotype created using this strain.
Contact JAX® Services jaxservices@jax.org for customized breeding options.Lith9I/LnJ/Lith9PERA/EiJ
involves: I/LnJ * PERA/EiJ
- liver/biliary system phenotype
- gallstones (MGI Ref ID J:84582)
- increased gallstone score
This mouse can be used to support research in many areas including:
Research Tools
Genetics Research (Evolution and Systematics Research)
Genetics Research (Gene Mapping: Polymorphisms)
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Lith9PERA/EiJ | ||
|---|---|---|---|
| Allele Name | PERA/EiJ | ||
| Allele Type | QTL | ||
| Strain of Origin | PERA/EiJ | ||
| Gene Symbol and Name | Lith9, lithogenic gene 9 | ||
| Chromosome | 17 | ||
| General Note | Lith9 exhibits additive inheritance. | ||
| Molecular Note | This allele confers increased gallstone score compared to I/LnJ. This allele confers susceptibility to gallstone formation compared to DBA/2J. | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Optimizing PCR Protocols
References
References
Selected Reference(s)
Chen Y; Duhl DM; Barsh GS. 1996. Opposite orientations of an inverted duplication and allelic variation at the mouse agouti locus. Genetics 144(1):265-77. [PubMed: 8878692] [MGI Ref ID J:35710]
Seidelmann SB; De Luca C; Leibel RL; Breslow JL; Tall AR; Welch CL. 2005. Quantitative trait locus mapping of genetic modifiers of metabolic syndrome and atherosclerosis in low-density lipoprotein receptor-deficient mice: identification of a locus for metabolic syndrome and increased atherosclerosis on chromosome 4. Arterioscler Thromb Vasc Biol 25(1):204-10. [PubMed: 15514201] [MGI Ref ID J:94548]
Velupillai P; Carroll JP; Benjamin TL. 2002. Susceptibility to polyomavirus-induced tumors in inbred mice: role of innate immune responses. J Virol 76(19):9657-63. [PubMed: 12208944] [MGI Ref ID J:78911]
Velupillai P; Yoshizawa I; Dey DC; Nahill SR; Carroll JP; Bronson RT; Benjamin TL. 1999. Wild-derived inbred mice have a novel basis of susceptibility to polyomavirus-induced tumors. J Virol 73(12):10079-85. [PubMed: 10559322] [MGI Ref ID J:58441]
Wahlsten D; Metten P; Crabbe JC. 2003. A rating scale for wildness and ease of handling laboratory mice: results for 21 inbred strains tested in two laboratories. Genes Brain Behav 2(2):71-9. [PubMed: 12884964] [MGI Ref ID J:83104]
Additional References
Cheah YC; Nadeau JH; Pugh S; Paigen B. 1994. New murine polymorphisms detected by random amplified polymorphic DNA (RAPD) PCR and mapped by use of recombinant inbred strains. Mamm Genome 5(12):762-7. [PubMed: 7894156] [MGI Ref ID J:22175]
Moy SS; Nadler JJ; Young NB; Nonneman RJ; Segall SK; Andrade GM; Crawley JN; Magnuson TR. 2008. Social approach and repetitive behavior in eleven inbred mouse strains. Behav Brain Res 191(1):118-29. [PubMed: 18440079] [MGI Ref ID J:138681]
Wittenburg H; Lyons MA; Li R; Churchill GA; Carey MC; Paigen B. 2003. FXR and ABCG5/ABCG8 as determinants of cholesterol gallstone formation from quantitative trait locus mapping in mice. Gastroenterology 125(3):868-81. [PubMed: 12949731] [MGI Ref ID J:84582]
Yang JN; Dudley J. 1992. Endogenous Mtv-8 or a closely linked sequence stimulates rearrangement of the downstream V kappa 9 gene. J Immunol 149(4):1242-51. [PubMed: 1323611] [MGI Ref ID J:1819]
Lith9PERA/EiJ relatedWittenburg H; Lyons MA; Li R; Churchill GA; Carey MC; Paigen B. 2003. FXR and ABCG5/ABCG8 as determinants of cholesterol gallstone formation from quantitative trait locus mapping in mice. Gastroenterology 125(3):868-81. [PubMed: 12949731] [MGI Ref ID J:84582]
Wittenburg H; Lyons MA; Li R; Kurtz U; Majssner J; Churchill GA; carey MC; Paigen B. 2005. Association of a Lithogenic Abcg5/Abcg8 allele on Chromosome 17 (Lith9) with Cholesterol Gallstone Formation in PERA/EiJ mice Mamm Genome 16(7):495-504. [PubMed: 16151694] [MGI Ref ID J:97424]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number FGB27
Colony Maintenance
Mating System Sibling x Sibling (Female x Male) Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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*Price(s) in US dollars ($)
Weeks of Age Price* Gender Individual Mouse Price $124.10 Female or Male
Additional Supply Details
| Pricing for International shipping destinations |
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*Price(s) in US dollars ($)
Weeks of Age Price* Gender Individual Mouse Price $161.40 Female or Male
Additional Supply Details
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement. |
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| Supply Notes |
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General Terms and Conditions
See Terms of Use
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
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