Strain Name:

PERA/EiJ

Stock Number:

000930

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Both PERA and PERC (Stock No. 001307) were derived from wild mice trapped in Peru. Wild-derived mice are genetically distinct from common laboratory mice for a number of complex phenotypic characteristics and are valuable tools for genetic mapping, evolution and systematics research.

Description

Strain Information

Type Inbred Strain;
Additional information on Inbred Strains.
Type Wild-Derived;
Additional information on Wild-Derived Mice.
Visit our online Nomenclature tutorial.
Mating SystemSibling x Sibling         (Female x Male)   01-MAR-06
SpeciesM. m. domesticus (Peru)
H2 Haplotypek
GenerationF114 (25-OCT-13)
Generation Definitions
Geographic OriginRimac Valley, Peru

Appearance
agouti
Related Genotype: A/A

Description
Both PERA and PERC (Stock No. 001307) were derived from wild mice trapped in Peru. PERA mice exhibit a moderate susceptibility to induced experimental autoimmune encephalitis (EAE). In comparison to other strains, disease onset is late, disease severity is high, and the mortality rate is 60% with a 50% spontaneous relapse. Wild-derived mice are genetically distinct from common laboratory mice for a number of complex phenotypic characteristics and are valuable tools for genetic mapping, evolution and systematics research.

Development
In 1961, founders were trapped for ME Wallace, University of Cambridge, by O Atteck in a Peruvian Yard that was used to dry maize cobs in Nana Village, Rimac Valley, Peru. These mice were held in a small, closed colony by Wallace. In 1971, at approximately F25, members of this colony were sent to EM Eicher and TH Roderick at The Jackson Laboratory where inbreeding continued. In 2003 this inbred strain reached F88.

Related Strains

Strains carrying   Ahrb-2 allele
000645   A/HeJ
000646   A/J
000130   B6.C-H17c/(HW14)ByJ
000370   B6.C-H38c/(HW119)ByJ
001026   BALB/cByJ
000653   BUB/BnJ
000659   C3H/HeJ
000656   CBA/J
000657   CE/J
000352   CXB2/ByJ
000353   CXB3/ByJ
000354   CXB4/ByJ
000355   CXB5/ByJ
000357   CXB7/ByJ
000673   HRS/J
000679   P/J
000644   SEA/GnJ
000280   SF/CamEiJ
View Strains carrying   Ahrb-2     (18 strains)

Strains carrying other alleles of Ahr
000690   129P3/J
000648   AKR/J
002920   B6(D2N).Spretus-Ahrb-3/J
002831   B6.129-Ahrtm1Bra/J
000136   B6.C-H34c/(HW22)ByJ
008599   B6.Cg-Cyp1a2/Cyp1a1tm2Dwn Ahrd Tg(CYP1A1,CYP1A2)1Dwn/DwnJ
002921   B6.D2N-Ahrd/J
002727   B6;129-Ahrtm1Bra/J
000652   BDP/J
000663   C57BL/6By
001139   C57BL/6ByJ
000664   C57BL/6J
000662   C57BLKS/J
000667   C57BR/cdJ
000668   C57L/J
000669   C58/J
000926   CAROLI/EiJ
000928   CAST/EiJ
000351   CXB1/ByJ
000356   CXB6/ByJ
002937   D2.B6-Ahrb-1/J
000671   DBA/2J
000674   I/LnJ
000675   LG/J
000676   LP/J
000677   MA/MyJ
000550   MOLF/EiJ
000684   NZB/BlNJ
000726   RBF/DnJ
000682   RF/J
000686   SJL/J
001146   SPRET/EiJ
000688   ST/bJ
006203   STOCK Ahrtm3.1Bra/J
000689   SWR/J
000693   WC/ReJ KitlSl/J
000933   YBR/EiJ
View Strains carrying other alleles of Ahr     (37 strains)

Additional Web Information

JAX® NOTES, Winter 1995; 460. Wild-Derived Mice Strains - Tips on Their Care and Handling.

Phenotype

Phenotype Information

View Phenotypic Data

Phenotypic Data
Mouse Phenome Database
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Lith9PERA/EiJ/Lith9PERA/EiJ

        involves: I/LnJ * PERA/EiJ
  • liver/biliary system phenotype
  • gallstones
    • increased gallstone score   (MGI Ref ID J:84582)

Lith9PERA/EiJ/?

        involves: I/LnJ * PERA/EiJ
  • liver/biliary system phenotype
  • gallstones
    • susceptibility to gallstone formation   (MGI Ref ID J:97424)

The following phenotype relates to a compound genotype created using this strain.
Contact JAX® Services jaxservices@jax.org for customized breeding options.

Lith9I/LnJ/Lith9PERA/EiJ

        involves: I/LnJ * PERA/EiJ
  • liver/biliary system phenotype
  • gallstones
    • increased gallstone score   (MGI Ref ID J:84582)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Research Tools
Genetics Research
      Evolution and Systematics Research
      Gene Mapping
      Gene Mapping: Polymorphisms

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Ahrb-2
Allele Name b-2 variant
Allele Type Not Applicable
Common Name(s) Ahb-2; Ahh;
Strain of OriginBALB/cBy
Gene Symbol and Name Ahr, aryl-hydrocarbon receptor
Chromosome 12
Gene Common Name(s) Ah; Ahh; Ahre; In; aromatic hydrocarbon responsiveness; aryl hydrocarbon hydroxylase; bHLHe76; dioxin receptor; inflammatory reactivity;
General Note C57BL/6 carries the responsive Ahrb allele; DBA/2 carries nonresponsive Ahrd. Heterozygotes (Ahrb/Ahrd) are responsive (J:5282). Later work identified a second (J:8895) and later a third (J:22144) allele conferring response. Thus the allele in C57, C58, and MA/My strains is now Ahrb-1; Ahrb-2 is carried by BALB/cBy, A, and C3H; and Ahrb-3 by Mus spretus, M. caroli, and MOLF/Ei. The nonresponsive strains AKR, DBA/2, and 129 carry Ahrd (J:22144). Nucleotide and amino acid sequence differences between Ahrb-1 and Ahrd have been determined (J:17460).

Strain of origin - this allele was found in BALB/cByJ, A/J, C3H/HeJ, CBA strains

Molecular Note This allele encodes a high affinity, heat labile, 104 kDa receptor containing 848 amino acids. Sequencing studies of cDNA from C57BL/6J congenic mice homozygous for this allele identified nucleotide substitutions in the ORF that would cause 5 amino acid differences between the C57BL/6J and BALB/cBy peptides, and 2 amino acid differences between the BALB/cBy and DBA/2J peptides. A T to C transition in exon 11 replaces the opal termination codon in the C57BL/6J allele with an arginine codon in the BALB/cByallele. This change would extend translation of the BALB/cBy mRNA by 43 amino acids, accounting for the larger size of the peptide produced by this allele (104 kDa, vs 95 kDa for the C57BL/6J allele). [MGI Ref ID J:15153] [MGI Ref ID J:22144]
 
Allele Symbol Lith9PERA/EiJ
Allele Name PERA/EiJ
Allele Type QTL
Strain of OriginPERA/EiJ
Gene Symbol and Name Lith9, lithogenic gene 9
Chromosome 17
General Note Lith9 exhibits additive inheritance.
Molecular Note This allele confers increased gallstone score compared to I/LnJ. This allele confers susceptibility to gallstone formation compared to DBA/2J.

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Chen Y; Duhl DM; Barsh GS. 1996. Opposite orientations of an inverted duplication and allelic variation at the mouse agouti locus. Genetics 144(1):265-77. [PubMed: 8878692]  [MGI Ref ID J:35710]

Petkov PM; Cassell MA; Sargent EE; Donnelly CJ; Robinson P; Crew V; Asquith S; Haar RV; Wiles MV. 2004. Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genomics 83(5):902-11. [PubMed: 15081119]  [MGI Ref ID J:89298]

Seidelmann SB; De Luca C; Leibel RL; Breslow JL; Tall AR; Welch CL. 2005. Quantitative trait locus mapping of genetic modifiers of metabolic syndrome and atherosclerosis in low-density lipoprotein receptor-deficient mice: identification of a locus for metabolic syndrome and increased atherosclerosis on chromosome 4. Arterioscler Thromb Vasc Biol 25(1):204-10. [PubMed: 15514201]  [MGI Ref ID J:94548]

Velupillai P; Carroll JP; Benjamin TL. 2002. Susceptibility to polyomavirus-induced tumors in inbred mice: role of innate immune responses. J Virol 76(19):9657-63. [PubMed: 12208944]  [MGI Ref ID J:78911]

Velupillai P; Yoshizawa I; Dey DC; Nahill SR; Carroll JP; Bronson RT; Benjamin TL. 1999. Wild-derived inbred mice have a novel basis of susceptibility to polyomavirus-induced tumors. J Virol 73(12):10079-85. [PubMed: 10559322]  [MGI Ref ID J:58441]

Wahlsten D; Metten P; Crabbe JC. 2003. A rating scale for wildness and ease of handling laboratory mice: results for 21 inbred strains tested in two laboratories. Genes Brain Behav 2(2):71-9. [PubMed: 12884964]  [MGI Ref ID J:83104]

Additional References

Cheah YC; Nadeau JH; Pugh S; Paigen B. 1994. New murine polymorphisms detected by random amplified polymorphic DNA (RAPD) PCR and mapped by use of recombinant inbred strains. Mamm Genome 5(12):762-7. [PubMed: 7894156]  [MGI Ref ID J:22175]

Ideraabdullah FY; de la Casa-Esperon E; Bell TA; Detwiler DA; Magnuson T; Sapienza C; de Villena FP. 2004. Genetic and haplotype diversity among wild-derived mouse inbred strains. Genome Res 14(10A):1880-7. [PubMed: 15466288]  [MGI Ref ID J:193384]

Lindsey JW. 1996. Characteristics of initial and reinduced experimental autoimmune encephalomyelitis. Immunogenetics 44(4):292-7. [PubMed: 8753860]  [MGI Ref ID J:35147]

Moy SS; Nadler JJ; Young NB; Nonneman RJ; Segall SK; Andrade GM; Crawley JN; Magnuson TR. 2008. Social approach and repetitive behavior in eleven inbred mouse strains. Behav Brain Res 191(1):118-29. [PubMed: 18440079]  [MGI Ref ID J:138681]

Poland A; Glover E. 1990. Characterization and strain distribution pattern of the murine Ah receptor specified by the Ahd and Ahb-3 alleles. Mol Pharmacol 38(3):306-12. [PubMed: 2169579]  [MGI Ref ID J:34840]

Wittenburg H; Lyons MA; Li R; Churchill GA; Carey MC; Paigen B. 2003. FXR and ABCG5/ABCG8 as determinants of cholesterol gallstone formation from quantitative trait locus mapping in mice. Gastroenterology 125(3):868-81. [PubMed: 12949731]  [MGI Ref ID J:84582]

Yang JN; Dudley J. 1992. Endogenous Mtv-8 or a closely linked sequence stimulates rearrangement of the downstream V kappa 9 gene. J Immunol 149(4):1242-51. [PubMed: 1323611]  [MGI Ref ID J:1819]

Ahrb-2 related

Nebert DW; Considine N; Owens IS. 1973. Genetic expression of aryl hydrocarbon hydroxylase induction. VI. Control of other aromatic hydrocarbon-inducible mono-oxygenase activities at or near the same genetic locus. Arch Biochem Biophys 157(1):148-59. [PubMed: 4716952]  [MGI Ref ID J:84313]

Nebert DW; Gielen JE. 1972. Genetic regulation of aryl hydrocarbon hydroxylase induction in the mouse. Fed Proc 31(4):1315-25. [PubMed: 4114109]  [MGI Ref ID J:5282]

Nebert DW; Jensen NM; Shinozuka H; Kunz HW; Gill TJ 3rd. 1982. The Ah phenotype. Survey of forty-eight rat strains and twenty inbred mouse strains. Genetics 100(1):79-87. [PubMed: 7095422]  [MGI Ref ID J:6809]

Nebert DW; Robinson JR; Niwa A; Kumaki K; Poland AP. 1975. Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse. J Cell Physiol 85(2 Pt 2 Suppl 1):393-414. [PubMed: 1091656]  [MGI Ref ID J:84317]

Niwa A; Kumaki K; Nebert DW; Poland AP. 1975. Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse. Distinction between the 'responsive' homozygote and heterozygote at the Ah locus. Arch Biochem Biophys 166(2):559-64. [PubMed: 1119809]  [MGI Ref ID J:84316]

Poland A; Glover E. 1990. Characterization and strain distribution pattern of the murine Ah receptor specified by the Ahd and Ahb-3 alleles. Mol Pharmacol 38(3):306-12. [PubMed: 2169579]  [MGI Ref ID J:34840]

Poland A; Glover E; Taylor BA. 1987. The murine Ah locus: a new allele and mapping to chromosome 12. Mol Pharmacol 32(4):471-8. [PubMed: 2823093]  [MGI Ref ID J:8895]

Poland A; Palen D; Glover E. 1994. Analysis of the four alleles of the murine aryl hydrocarbon receptor. Mol Pharmacol 46(5):915-21. [PubMed: 7969080]  [MGI Ref ID J:22144]

Robinson JR; Considine N; Nebert DW. 1974. Genetic expression of aryl hydrocarbon hydroxylase induction. Evidence for the involvement of other genetic loci. J Biol Chem 249(18):5851-9. [PubMed: 4413562]  [MGI Ref ID J:84315]

Schmid FA; Pena RC; Robinson W; Tarnowski GS. 1967. Toxicity of intraperitoneal injections of 7, 12-dimethylbenz[a]anthracene in inbred mice. Cancer Res 27(3):558-62. [PubMed: 6021513]  [MGI Ref ID J:26440]

Schmidt JV; Carver LA; Bradfield CA. 1993. Molecular characterization of the murine Ahr gene. Organization, promoter analysis, and chromosomal assignment. J Biol Chem 268(29):22203-9. [PubMed: 8408082]  [MGI Ref ID J:15153]

Smith AG; Clothier B; Robinson S; Scullion MJ; Carthew P; Edwards R; Luo J; Lim CK; Toledano M. 1998. Interaction between iron metabolism and 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice with variants of the Ahr gene: a hepatic oxidative mechanism. Mol Pharmacol 53(1):52-61. [PubMed: 9443932]  [MGI Ref ID J:45850]

Thomas PE; Hutton JJ; Taylor BA. 1973. Genetic relationship between aryl hydrocarbon hydroxylase inducibility and chemical carcinogen induced skin ulceration in mice. Genetics 74(4):655-9. [PubMed: 4750810]  [MGI Ref ID J:5387]

Lith9PERA/EiJ related

Wittenburg H; Lyons MA; Li R; Churchill GA; Carey MC; Paigen B. 2003. FXR and ABCG5/ABCG8 as determinants of cholesterol gallstone formation from quantitative trait locus mapping in mice. Gastroenterology 125(3):868-81. [PubMed: 12949731]  [MGI Ref ID J:84582]

Wittenburg H; Lyons MA; Li R; Kurtz U; Majssner J; Churchill GA; carey MC; Paigen B. 2005. Association of a Lithogenic Abcg5/Abcg8 allele on Chromosome 17 (Lith9) with Cholesterol Gallstone Formation in PERA/EiJ mice Mamm Genome 16(7):495-504. [PubMed: 16151694]  [MGI Ref ID J:97424]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           FGB27

Colony Maintenance

Mating SystemSibling x Sibling         (Female x Male)   01-MAR-06
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


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Price per mouse (US dollars $)Gender
Individual Mouse $182.00Female or Male  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)Gender
Individual Mouse $236.60Female or Male  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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