Strain Name: |
B6 x STOCK Epha4rb/J |
|---|---|
Stock Number: |
000938 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Genes & Alleles | Epha4; Epha4rb; |
Product Information
Strain Details
Type JAX® GEMM® Strain - Mutant Stock Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Spontaneous Mutation Species laboratory mouse Strain Development
The rb mutation arose spontaneously on the C57BL/6J background in 1964 at The Jackson Laboratory. It was outcrossed to C3H in approximately 1968 and in later years was crossed to C57BL/6J or (B6 x C3H)F1 to improve colony maintenance prior to cryopreservation in 1984. To generate embryos for cryopreservation, C57BL/6J females were bred with heterozygous males that were the F1 of either a cross to C57BL/6J or (B6 x C3H)F1.
Mammalian Phenotype Terms assigned by genotype |
Gene & Allele Details
| Allele Symbol | Epha4rb | ||
|---|---|---|---|
| Allele Name | rabbit | ||
| Strain of Origin | C57BL/6J | ||
| Gene Symbol and Name | Epha4, Eph receptor A4 | ||
| Chromosome | 1 | ||
| Gene Common Name(s) | 2900005C20Rik; AI385584; Cek8; HEK8; RGD1560587; RIKEN cDNA 2900005C20 gene; SEK; Sek; Sek1; TYRO1; expressed sequence AI385584; rabbit; rb; segmentation receptor tyrosine kinase; | ||
| Molecular Note | The rb mouse arose in 1964 at the Jackson Laboratory. This mouse was identified as an allele at the Epha4 locus based complementation analysis using the Epha4Gt(pGT1TM)38Wcs allele. The mutation at the level of the sequence has not been reported. [MGI Ref ID J:87289] | ||
Related Strains
Strains carrying Epha4rb allele
001502 C3Sn.B6-Epha4rb/J View Strains carrying Epha4rb (1 strain)
003129 C57BL/6J-Epha4rb-2J/J
Research Applications
This mouse can be used to support research in many areas including:Epha4rb related
Neurobiology Research
Ataxia (Movement) Defects
References
Additional ReferencesPrice and Supply Information
| Strain Name: | B6 x STOCK Epha4rb/J |
| Stock Number: | 000938 |
Price Details
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to the Supply Notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery of Strains Needing Progeny Testing. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two untested males and two untested females (two pairs) will be recovered, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the overall recovery time to approximately 25 weeks. However, all pups recovered will be sent. Progeny testing is required to identify the genotype of mice of this strain, as a genotyping assay is not available. This type of testing involves breeding the recovered animals and assessing the phenotype of the offspring in order to identify animals carrying the mutation of interest. We can perform the progeny testing for you as a service or we can ship all recovered animals (at least two untested pairs) to you for progeny testing at your facility. If you perform the progeny testing, there is NO guarantee that a carrier will be identified. If we perform progeny testing as a service, additional breeding time will be required. In this case, when a male and female (one pair) are identified that carry the mutation, they and their offspring will be shipped. Delivery time for strains requiring progeny testing often exceeds 25 weeks and may take 12 months or more due to the difficulties in breeding some strains. The progeny testing cost is in addition to the recovery cost and is based on the number of boxes used and the time taken to produce the mice identified as carrying the mutation. Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Please contact Customer Service for more information on the cost of progeny testing for a strain: Tel: 1-800-422-6423 or 1-207-288-5845. Cryorecovery to establish a Dedicated Supply for greater quantities of mice |
| Licensing | See General Terms and Conditions below |
General Terms and Conditions
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The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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