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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Type Congenic; Major Histocompatibility Congenic; Mutant Strain; Additional information on Genetically Engineered Mutant Mice. Species laboratory mouse Generation N10 F11p (03-OCT-04)
Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying C3c allele
000833 B6.SJL-C3c/J 000966 B6.SJL-H2s C3c/1CyJ View Strains carrying C3c (2 strains)
002089 AK.B6-H2b Fv1b/J 002090 AK.B6-H2b/J 001094 AK.L-H2b/1CyTyJ 002995 B6 x C.B10-H2b/LiMcdJ-Fbn2fp-2J/J 001041 BKS.B6-H2b/J 001892 BRVR.B10-H2b/J 001952 C.B10-H2b/LilMcdJ 000438 C3.SW-H2b/SnJ 000435 D1.LP-H2b H2-T18b?/SnJ 002591 NOD.B10Sn-H2b/J 006935 NOD.Cg-H2b thnh/J
003641 B6.129S4-C3tm1Crr/J
Additional Web Information
Congenic Nomenclature
Phenotype
Phenotype Information
Currently there is no phenotype information for this strain.This mouse can be used to support research in many areas including:H2b related
Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Genes & Alleles
Gene & Allele Information
| Allele Symbol | C3c | ||
|---|---|---|---|
| Allele Name | fast electrophoretic ability | ||
| Allele Type | Not Applicable | ||
| Common Name(s) | C3-1c; F allele; Plpb; | ||
| Gene Symbol and Name | C3, complement component 3 | ||
| Chromosome | 17 | ||
| Gene Common Name(s) | AI255234; ARMD9; ASP; CPAMD1; Plp; acylation stimulating protein; complement factor 3; expressed sequence AI255234; | ||
| Molecular Note | This allele is a polymorphism resulting in a protein of fast electrophoretic ability compared to C3b (slow) and C3a (intermediate). The SJL/J, SWR/J, DA/HuSn, WB/Re, IS/Cam, SF/Cam, AEJ/GnRk and AKR.M strains carry this allele. | ||
| Allele Symbol | H2b | ||
| Allele Name | b variant | ||
| Allele Type | Not Applicable | ||
| Gene Symbol and Name | H2, histocompatibility-2, MHC | ||
| Chromosome | 17 | ||
| Gene Common Name(s) | H-2; MHC-II; | ||
| General Note | The b variant has been observed in the following strains: C57BL/10, C57BL/10SnJ, BXSB/MpJ, C57BL/6J, C57L/J, LP/J, 129P3/J | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Optimizing PCR Protocols
References
References
Additional References
C3c relatedH2b relatedNatsuume-Sakai S; Amano S; Hayakawa JI; Takahashi M. 1978. Preparation of an alloantiserum to murine C3 and demonstration of multiple alleles. J Immunol 121(5):2025-9. [PubMed: 101594] [MGI Ref ID J:6057]
Whitney JB; Taylor BA; Cherry M. 1978. Plasma protein (Plp) Mouse News Lett 58:49. [MGI Ref ID J:13750]
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Fischer Lindahl K. 1997. On naming H2 haplotypes: functional significance of MHC class Ib alleles. Immunogenetics 46(1):53-62. [PubMed: 9148789] [MGI Ref ID J:41130]
Ford MS; Zhang ZX; Chen W; Zhang L. 2006. Double-negative T regulatory cells can develop outside the thymus and do not mature from CD8+ T cell precursors. J Immunol 177(5):2803-9. [PubMed: 16920915] [MGI Ref ID J:139556]
Gerloni M; Castiglioni P; Zanetti M. 2005. The cooperation between two CD4 T cells induces tumor protective immunity in MUC.1 transgenic mice. J Immunol 175(10):6551-9. [PubMed: 16272309] [MGI Ref ID J:119394]
Ghendler Y; Hussey RE; Witte T; Mizoguchi E; Clayton LK; Bhan AK; Koyasu S; Chang HC; Reinherz EL. 1997. Double-positive T cell receptor(high) thymocytes are resistant to peptide/major histocompatibility complex ligand-induced negative selection. Eur J Immunol 27(9):2279-89. [PubMed: 9341770] [MGI Ref ID J:133112]
Ghendler Y; Teng MK; Liu JH; Witte T; Liu J; Kim KS; Kern P; Chang HC; Wang JH; Reinherz EL. 1998. Differential thymic selection outcomes stimulated by focal structural alteration in peptide/major histocompatibility complex ligands. Proc Natl Acad Sci U S A 95(17):10061-6. [PubMed: 9707600] [MGI Ref ID J:119802]
Grob P; Schijns VE; van den Broek MF; Cox SP; Ackermann M; Suter M. 1999. Role of the individual interferon systems and specific immunity in mice in controlling systemic dissemination of attenuated pseudorabies virus infection. J Virol 73(6):4748-54. [PubMed: 10233935] [MGI Ref ID J:110066]
Gubbels MR; Jorgensen TN; Metzger TE; Menze K; Steele H; Flannery SA; Rozzo SJ; Kotzin BL. 2005. Effects of MHC and gender on lupus-like autoimmunity in Nba2 congenic mice. J Immunol 175(9):6190-6. [PubMed: 16237116] [MGI Ref ID J:119371]
Horwitz MS; Krahl T; Fine C; Lee J; Sarvetnick N. 1999. Protection from lethal coxsackievirus-induced pancreatitis by expression of gamma interferon. J Virol 73(3):1756-66. [PubMed: 9971752] [MGI Ref ID J:120473]
Jenkinson EJ; Van Ewijk W; Owen JJ. 1981. Major histocompatibility complex antigen expression on the epithelium of the developing thymus in normal and nude mice. J Exp Med 153(2):280-92. [PubMed: 6940949] [MGI Ref ID J:109960]
Jiang W; Anderson MS; Bronson R; Mathis D; Benoist C. 2005. Modifier loci condition autoimmunity provoked by Aire deficiency. J Exp Med 202(6):805-15. [PubMed: 16172259] [MGI Ref ID J:107432]
Kageyama Y; Koide Y; Yoshida A; Uchijima M; Arai T; Miyamoto S; Ozeki T; Hiyoshi M; Kushida K; Inoue T. 1998. Reduced susceptibility to collagen-induced arthritis in mice deficient in IFN-gamma receptor. J Immunol 161(3):1542-8. [PubMed: 9686622] [MGI Ref ID J:119066]
Klein J; Figueroa F; David CS. 1983. H-2 haplotypes, genes and antigens: second listing. II. The H-2 complex. Immunogenetics 17(6):553-96. [PubMed: 6407984] [MGI Ref ID J:7097]
Krupnick AS; Gelman AE; Barchet W; Richardson S; Kreisel FH; Turka LA; Colonna M; Patterson GA; Kreisel D. 2005. Murine vascular endothelium activates and induces the generation of allogeneic CD4+25+Foxp3+ regulatory T cells. J Immunol 175(10):6265-70. [PubMed: 16272276] [MGI Ref ID J:119348]
Laky K; Lewis JM; Tigelaar RE; Puddington L. 2003. Distinct requirements for IL-7 in development of TCR gamma delta cells during fetal and adult life. J Immunol 170(8):4087-94. [PubMed: 12682238] [MGI Ref ID J:125438]
Lehmann-Grube F; Lohler J; Utermohlen O; Gegin C. 1993. Antiviral immune responses of lymphocytic choriomeningitis virus-infected mice lacking CD8+ T lymphocytes because of disruption of the beta 2-microglobulin gene. J Virol 67(1):332-9. [PubMed: 8093219] [MGI Ref ID J:111102]
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Leng Q; Ge Q; Nguyen T; Eisen HN; Chen J. 2007. Stage-dependent reactivity of thymocytes to self-peptide--MHC complexes. Proc Natl Acad Sci U S A 104(12):5038-43. [PubMed: 17360333] [MGI Ref ID J:120081]
Lin H; Rathmell JC; Gray GS; Thompson CB; Leiden JM; Alegre ML. 1998. Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28. J Exp Med 188(1):199-204. [PubMed: 9653096] [MGI Ref ID J:115143]
Longhi MP; Sivasankar B; Omidvar N; Morgan BP; Gallimore A. 2005. Cutting edge: murine CD59a modulates antiviral CD4+ T cell activity in a complement-independent manner. J Immunol 175(11):7098-102. [PubMed: 16301611] [MGI Ref ID J:122201]
Medema JP; de Jong J; van Hall T; Melief CJ; Offringa R. 1999. Immune escape of tumors in vivo by expression of cellular FLICE-inhibitory protein. J Exp Med 190(7):1033-8. [PubMed: 10510093] [MGI Ref ID J:115086]
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Merino R; Shibata T; De Kossodo S; Izui S. 1989. Differential effect of the autoimmune Yaa and lpr genes on the acceleration of lupus-like syndrome in MRL/MpJ mice. Eur J Immunol 19(11):2131-7. [PubMed: 2599002] [MGI Ref ID J:108759]
Miyashita N; Migita S; Moriwaki K. 1987. Effects of H-2 complex and non-H-2 background on urethane-induced chromosomal aberrations in mice. Mutat Res 176(1):59-67. [PubMed: 3099189] [MGI Ref ID J:109945]
Mizoguchi E; Mizoguchi A; Preffer FI; Bhan AK. 2000. Regulatory role of mature B cells in a murine model of inflammatory bowel disease. Int Immunol 12(5):597-605. [PubMed: 10784605] [MGI Ref ID J:110524]
Murphy DB. 1986. Overview: the murine MHC. In: Handbook of Experimental Immunology. Vol. 3, Genetic and Molecular Immunology. Blackwell Scientific Publ., Oxford. [MGI Ref ID J:30731]
Oberg L; Johansson S; Michaelsson J; Tomasello E; Vivier E; Karre K; Hoglund P. 2004. Loss or mismatch of MHC class I is sufficient to trigger NK cell-mediated rejection of resting lymphocytes in vivo - role of KARAP/DAP12-dependent and -independent pathways. Eur J Immunol 34(6):1646-53. [PubMed: 15162434] [MGI Ref ID J:115484]
Panoskaltsis-Mortari A; Hermanson JR; Taras E; Wangensteen OD; Charo IF; Rollins BJ; Blazar BR. 2004. Post-BMT lung injury occurs independently of the expression of CCL2 or its receptor, CCR2, on host cells. Am J Physiol Lung Cell Mol Physiol 286(2):L284-92. [PubMed: 14527928] [MGI Ref ID J:101226]
Pereira P; Zijlstra M; McMaster J; Loring JM; Jaenisch R; Tonegawa S. 1992. Blockade of transgenic gamma delta T cell development in beta 2-microglobulin deficient mice. EMBO J 11(1):25-31. [PubMed: 1531458] [MGI Ref ID J:111105]
Peterson KE; Iwashiro M; Hasenkrug KJ; Chesebro B. 2000. Major histocompatibility complex class I gene controls the generation of gamma interferon-producing CD4(+) and CD8(+) T cells important for recovery from friend retrovirus-induced leukemia J Virol 74(11):5363-7. [PubMed: 10799615] [MGI Ref ID J:62492]
Podolin PL; Pressey A; DeLarato NH; Fischer PA; Peterson LB; Wicker LS. 1993. I-E+ nonobese diabetic mice develop insulitis and diabetes. J Exp Med 178(3):793-803. [PubMed: 8350054] [MGI Ref ID J:14178]
Porcellini S; Traggiai E; Schenk U; Ferrera D; Matteoli M; Lanzavecchia A; Michalak M; Grassi F. 2006. Regulation of peripheral T cell activation by calreticulin. J Exp Med 203(2):461-71. [PubMed: 16492806] [MGI Ref ID J:119147]
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Health & husbandry
Health & Colony Maintenance Information
Currently there no information available for this strain. This may be due to the supply level of this strain.
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
|
*Price(s) in US dollars ($)
Price* Cryorecovery Fee $1900.00
Additional Supply Details
| Pricing for International shipping destinations |
|
*Price(s) in US dollars ($)
Price* Cryorecovery Fee $2470.00
Additional Supply Details
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
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Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of MICE, products or services, The Jackson Laboratory will, at its option, provide credit or replacement for the MICE or product received or the services provided.
No Liability
In no event shall The Jackson Laboratory, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, products or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of The Jackson Laboratory, its agents or employees. In purchasing or receiving MICE, products or services from The Jackson Laboratory, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges The Jackson Laboratory from all such causes of action or damages, and further agrees to defend and indemnify The Jackson Laboratory from any costs or damages arising out of any third party claims.
MICE and biological materials are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to The Jackson Laboratory’s MICE, products and services. In addition, special terms and conditions of sale of certain MICE, products and services may be set forth separately in The Jackson Laboratory web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, products and services by The Jackson Laboratory, and by its licensees and distributors.
Acceptance of delivery of MICE, products or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on The Jackson Laboratory, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, products services by The Jackson Laboratory.