| |||||||
Former Names AKXD-28/TyJ (Changed: 15-DEC-04 ) Type Recombinant Inbred (Ri); Additional information on Recombinant Inbred Mice. Species laboratory mouse RI progenitor AKR/J DBA/2J H2 Haplotype k Generation F51pF26 Appearance
chocolate brown (nonagouti brown)
Related Genotype: Typr1b/Tyrp1b Myo5a+/Myo5a+Description
Similar to DBA/2J, AKXD28 mice develop an age-related glaucoma characterized by intraocular pressure elevation, retinal ganglion loss, and optic nerve excavation. Although both glaucoma related alleles, GpnmbR150X and Tyrp1isa, are present in AKXD28, the phenotype differs from DBA/2J. AKXD28 mice do not develop iris pigment dispersion (IPD) and develop a more severe retinal damage.
AKXD Strains
001005 AKXD1/TyJ 001017 AKXD10/TyJ 001003 AKXD11/TyJ 000765 AKXD13/TyJ 000779 AKXD14/TyJ 000954 AKXD15/TyJ 000958 AKXD16/TyJ 001093 AKXD18/TyJ 000776 AKXD2/TyJ 001001 AKXD20/TyJ 001062 AKXD21/TyJ 000947 AKXD22/TyJ 000780 AKXD23/TyJ 000969 AKXD24/TyJ 000949 AKXD25/TyJ 000764 AKXD27/TyJ 000959 AKXD3/TyJ 000777 AKXD6/TyJ 000763 AKXD9/TyJ View AKXD Strains (19 strains)
Strains carrying GpnmbR150X allele
000671 DBA/2J View Strains carrying GpnmbR150X (1 strain)
Strains carrying Tyrp1isa allele
000671 DBA/2J View Strains carrying Tyrp1isa (1 strain)
Strains carrying other alleles of Gpnmb
007048 DBA/2J-Gpnmb+/SjJ View Strains carrying other alleles of Gpnmb (1 strain)
Strains carrying other alleles of Tyrp1
000004 ABP/LeJ 000571 B6.Cg-Whrnwi Tyrp1b/+ +/J 000027 B6.D-Tyrp1b m/J 000068 C57BL/6J-Tyrp1b-J/J 000093 C57BL/6J-Tyrp1b-cJ/J 000670 DBA/1J 003588 LT/SvEi 006252 LT/SvEiJ 000265 MY/HuLeJ 001045 SI/Col Tyrp1b Dnahc11iv/J 002142 STOCK 11R30m/J 000064 STOCK a Tyrp1b Sisi/J 002238 STOCK a Tyrp1b shmy/J 001432 STOCK a/a Tyrp1b sks/Tyrp1b +/J 000594 STOCK T(2;8)26H a/T(2;8)26H a Tyrp1+/Tyrp1b/J 001101 STOCK T(3;4)5Rk Tyrp1b/J 000274 TSJ/LeJ View Strains carrying other alleles of Tyrp1 (17 strains)
View Phenotypic Data
Phenotypic Data
Mouse Phenome Database
Wellcome Trust Centre for Human Genetics: Mouse Recombinant Inbred Line (RIL) Genotype Data for AKXD RI Line
View Research Applications
Research Applications
This mouse can be used to support research in many areas including:
Research Tools
Cancer Research (genes regulating lymphoma development)
Genetics Research (Gene Mapping: Tools for QTL Mapping, Segregation and Linkage Analysis)
Sensorineural Research
Eye Defects (hereditary glaucoma)
| Allele Symbol | GpnmbR150X | ||
|---|---|---|---|
| Allele Name | iris pigment dispersion | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | Gpnmbipd; | ||
| Strain of Origin | DBA/2J | ||
| Gene Symbol and Name | Gpnmb, glycoprotein (transmembrane) nmb | ||
| Chromosome | 6 | ||
| Gene Common Name(s) | Dchil; HGFIN; NMB; Osteoactivin; dendritic cell associated heparan sulfate proteoglycans dependent integrin ligand; ipd; iris pigment dispersion; | ||
| General Note |
The mouse strain DBA/2J develops glaucoma associated with iris stromal atrophy and iris pigment dispersion phneotypes. Genetic studies defined two separate loci that contribute to the overall phenotype in the DBA/2J mouse, ipd and isa. Either mutation in a homozygous state contributes to glaucoma, while mice homozygous for both mutations develop an earlier onset and more severe iris disease. | ||
| Molecular Note | The underlying mutation responsible for the phenotype in the iris pigment dispersion mouse was identified as a C to T substitution that resulted in a nonsense mutation, Arg150stop. [MGI Ref ID J:75398] | ||
| Allele Symbol | Tyrp1isa | ||
| Allele Name | iris stromal atrophy | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | isa; | ||
| Strain of Origin | DBA/2J | ||
| Gene Symbol and Name | Tyrp1, tyrosinase-related protein 1 | ||
| Chromosome | 4 | ||
| Gene Common Name(s) | B; CAS2; CATB; GP75; TRP; TRP-1; TRP1; TYRP; Tyrp; b; b-PROTEIN; brown; iris stromal atrophy; isa; tyrosinase-related protein; | ||
| General Note |
The mouse strain DBA/2J develops glaucoma associated with iris stromal atrophy and iris pigment dispersion phneotypes. Genetic studies defined two separate loci that contribute to the overall phenotype in the DBA/2J mouse, ipd and isa. Either mutation in a homozygous state contributes to glaucoma, while mice homozygous for both mutations develop an earlier onset and more severe iris disease. | ||
| Molecular Note | Expression of a BAC containing the wild-type Tyrp1 gene rescues the phenotype of isa mice. The isa phenotype has been identified in numerous aged stocks carrying Tyrp1b allele. It is therefore most probable, that the Tyrp1b alleleis responsible for the isa phenotype. [MGI Ref ID J:75398] | ||
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Optimizing PCR Protocols
Anderson MG; Smith RS; Savinova OV; Hawes NL; Chang B; Zabaleta A; Wilpan R; Heckenlively JR; Davisson M; John SW. 2001. Genetic modification of glaucoma associated phenotypes between AKXD-28/Ty and DBA/2J mice. BMC Genet 2(1):1. [PubMed: 11178107] [MGI Ref ID J:82878]
GpnmbR150X relatedTyrp1isa relatedAbdelmagid SM; Barbe MF; Rico MC; Salihoglu S; Arango-Hisijara I; Selim AH; Anderson MG; Owen TA; Popoff SN; Safadi FF. 2008. Osteoactivin, an anabolic factor that regulates osteoblast differentiation and function. Exp Cell Res 314(13):2334-51. [PubMed: 18555216] [MGI Ref ID J:138006]
Anderson MG; Libby RT; Mao M; Cosma IM; Wilson LA; Smith RS; John SW. 2006. Genetic context determines susceptibility to intraocular pressure elevation in a mouse pigmentary glaucoma. BMC Biol 4:20. [PubMed: 16827931] [MGI Ref ID J:128215]
Anderson MG; Nair KS; Amonoo LA; Mehalow A; Trantow CM; Masli S; John SW. 2008. GpnmbR150X allele must be present in bone marrow derived cells to mediate DBA/2J glaucoma. BMC Genet 9:30. [PubMed: 18402690] [MGI Ref ID J:134670]
Anderson MG; Smith RS; Hawes NL; Zabaleta A; Chang B; Wiggs JL; John SW. 2002. Mutations in genes encoding melanosomal proteins cause pigmentary glaucoma in DBA/2J mice. Nat Genet 30(1):81-5. [PubMed: 11743578] [MGI Ref ID J:75398]
Anderson MG; Smith RS; Savinova OV; Hawes NL; Chang B; Zabaleta A; Wilpan R; Heckenlively JR; Davisson M; John SW. 2001. Genetic modification of glaucoma associated phenotypes between AKXD-28/Ty and DBA/2J mice. BMC Genet 2(1):1. [PubMed: 11178107] [MGI Ref ID J:82878]
Chang B; Smith RS; Hawes NL; Anderson MG; Zabaleta A; Savinova O ; Roderick TH ; Heckenlively JR ; Davisson MT ; John SW. 1999. Interacting loci cause severe iris atrophy and glaucoma in DBA/2J mice. Nat Genet 21(4):405-9. [PubMed: 10192392] [MGI Ref ID J:54013]
Howell GR; Libby RT; Jakobs TC; Smith RS; Phalan FC; Barter JW; Barbay JM; Marchant JK; Mahesh N; Porciatti V; Whitmore AV; Masland RH; John SW. 2007. Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma. J Cell Biol 179(7):1523-37. [PubMed: 18158332] [MGI Ref ID J:131073]
Inman DM; Sappington RM; Horner PJ; Calkins DJ. 2006. Quantitative correlation of optic nerve pathology with ocular pressure and corneal thickness in the DBA/2 mouse model of glaucoma. Invest Ophthalmol Vis Sci 47(3):986-96. [PubMed: 16505033] [MGI Ref ID J:108329]
Jakobs TC; Libby RT; Ben Y; John SW; Masland RH. 2005. Retinal ganglion cell degeneration is topological but not cell type specific in DBA/2J mice. J Cell Biol 171(2):313-25. [PubMed: 16247030] [MGI Ref ID J:104518]
Libby RT; Li Y; Savinova OV; Barter J; Smith RS; Nickells RW; John SW. 2005. Susceptibility to neurodegeneration in a glaucoma is modified by bax gene dosage. PLoS Genet 1(1):e4. [PubMed: 16103918] [MGI Ref ID J:100118]
Zhou X; Li F; Kong L; Tomita H; Li C; Cao W. 2005. Involvement of inflammation, degradation, and apoptosis in a mouse model of glaucoma. J Biol Chem 280(35):31240-8. [PubMed: 15985430] [MGI Ref ID J:101163]
Anderson MG; Smith RS; Hawes NL; Zabaleta A; Chang B; Wiggs JL; John SW. 2002. Mutations in genes encoding melanosomal proteins cause pigmentary glaucoma in DBA/2J mice. Nat Genet 30(1):81-5. [PubMed: 11743578] [MGI Ref ID J:75398]
Anderson MG; Smith RS; Savinova OV; Hawes NL; Chang B; Zabaleta A; Wilpan R; Heckenlively JR; Davisson M; John SW. 2001. Genetic modification of glaucoma associated phenotypes between AKXD-28/Ty and DBA/2J mice. BMC Genet 2(1):1. [PubMed: 11178107] [MGI Ref ID J:82878]
Chang B; Smith RS; Hawes NL; Anderson MG; Zabaleta A; Savinova O ; Roderick TH ; Heckenlively JR ; Davisson MT ; John SW. 1999. Interacting loci cause severe iris atrophy and glaucoma in DBA/2J mice. Nat Genet 21(4):405-9. [PubMed: 10192392] [MGI Ref ID J:54013]
Inman DM; Sappington RM; Horner PJ; Calkins DJ. 2006. Quantitative correlation of optic nerve pathology with ocular pressure and corneal thickness in the DBA/2 mouse model of glaucoma. Invest Ophthalmol Vis Sci 47(3):986-96. [PubMed: 16505033] [MGI Ref ID J:108329]
Jakobs TC; Libby RT; Ben Y; John SW; Masland RH. 2005. Retinal ganglion cell degeneration is topological but not cell type specific in DBA/2J mice. J Cell Biol 171(2):313-25. [PubMed: 16247030] [MGI Ref ID J:104518]
John SW; Anderson MG; Smith RS. 1999. Mouse genetics: a tool to help unlock the mechanisms of glaucoma. J Glaucoma 8(6):400-12. [PubMed: 10604301] [MGI Ref ID J:59796]
Libby RT; Li Y; Savinova OV; Barter J; Smith RS; Nickells RW; John SW. 2005. Susceptibility to neurodegeneration in a glaucoma is modified by bax gene dosage. PLoS Genet 1(1):e4. [PubMed: 16103918] [MGI Ref ID J:100118]
Zhou X; Li F; Kong L; Tomita H; Li C; Cao W. 2005. Involvement of inflammation, degradation, and apoptosis in a mouse model of glaucoma. J Biol Chem 280(35):31240-8. [PubMed: 15985430] [MGI Ref ID J:101163]
Currently there no information available for this strain. This may be due to the supply level of this strain.
| Pricing for USA, Canada and Mexico shipping destinations |
|
*Price(s) in US dollars ($)
Weeks of Age Price* Gender Cryorecovery Fee $1900.00
| Pricing for International shipping destinations |
|
*Price(s) in US dollars ($)
Weeks of Age Price* Gender Cryorecovery Fee $2470.00
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
|
Purchasing Information
JAX® Mice Orders
Surgical Services
Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. THE LABORATORY EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of MICE, products or services, The Jackson Laboratory will, at its option, provide credit or replacement for the MICE or product received or the services provided.
In no event shall The Jackson Laboratory, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, products or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of The Jackson Laboratory, its agents or employees. In purchasing or receiving MICE, products or services from The Jackson Laboratory, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges The Jackson Laboratory from all such causes of action or damages, and further agrees to defend and indemnify The Jackson Laboratory from any costs or damages arising out of any third party claims.
MICE and biological materials are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to The Jackson Laboratory’s MICE, products and services. In addition, special terms and conditions of sale of certain MICE, products and services may be set forth separately in The Jackson Laboratory web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, products and services by The Jackson Laboratory, and by its licensees and distributors.
Acceptance of delivery of MICE, products or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on The Jackson Laboratory, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, products services by The Jackson Laboratory.