Strain Name:

AKXD28/TyJ

Stock Number:

000957

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Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names AKXD-28/TyJ    (Changed: 15-DEC-04 )
Type Recombinant Inbred (RI);
Additional information on Recombinant Inbred Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse
RI progenitor AKR/J DBA/2J
H2 Haplotypek
GenerationF51pF26
Generation Definitions

Appearance
chocolate brown (nonagouti brown)
Related Genotype: Typr1b/Tyrp1b Myo5a+/Myo5a+

Description
Similar to DBA/2J, AKXD28 mice develop an age-related glaucoma characterized by intraocular pressure elevation, retinal ganglion loss, and optic nerve excavation. Although both glaucoma related alleles, GpnmbR150X and Tyrp1isa, are present in AKXD28, the phenotype differs from DBA/2J. AKXD28 mice do not develop iris pigment dispersion (IPD) and develop a more severe retinal damage.

Related Strains

AKXD Strains
001005   AKXD1/TyJ
001017   AKXD10/TyJ
001003   AKXD11/TyJ
000765   AKXD13/TyJ
000779   AKXD14/TyJ
000954   AKXD15/TyJ
000958   AKXD16/TyJ
001093   AKXD18/TyJ
000776   AKXD2/TyJ
001001   AKXD20/TyJ
001062   AKXD21/TyJ
000947   AKXD22/TyJ
000780   AKXD23/TyJ
000969   AKXD24/TyJ
000949   AKXD25/TyJ
000764   AKXD27/TyJ
000959   AKXD3/TyJ
000777   AKXD6/TyJ
000763   AKXD9/TyJ
View AKXD Strains     (19 strains)

Strains carrying   GpnmbR150X allele
000671   DBA/2J
View Strains carrying   GpnmbR150X     (1 strain)

Strains carrying   Tyrp1isa allele
000671   DBA/2J
View Strains carrying   Tyrp1isa     (1 strain)

Strains carrying other alleles of Gpnmb
018554   B6N(Cg)-Gpnmbtm1.1(KOMP)Vlcg/J
024704   D2.Cg-Gpnmb+Tg(Thy1-CFP)23Jrs/SjJ
025018   D2.Cg-Gpnmb+Tg(Thy1-YFP)HJrs/SjJ
007048   DBA/2J-Gpnmb+/SjJ
View Strains carrying other alleles of Gpnmb     (4 strains)

View Strains carrying other alleles of Tyrp1     (17 strains)

Phenotype

Phenotype Information

View Phenotypic Data

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Albinism, Oculocutaneous, Type III; OCA3   (TYRP1)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

       
  • tumorigenesis
  • decreased lymphoma incidence
    • unlike most other AKXD RI strains of this set, the majority of 20 females survived to 18 months of age in good health and lymphomas were not the major cause of death   (MGI Ref ID J:4179)
  • increased lymphoblastic lymphoma incidence
    • of 3 lymphomas characterized 1 was a T cell lymphoblastic lymphoma   (MGI Ref ID J:69716)
  • increased splenic marginal zone lymphoma incidence
    • of 3 lymphomas characterized 2 were splenic marginal zone lymphomas   (MGI Ref ID J:69716)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Research Tools
Cancer Research
      genes regulating lymphoma development
Genetics Research
      Gene Mapping
      Gene Mapping: Tools for QTL Mapping, Segregation and Linkage Analysis

Sensorineural Research
Eye Defects
      hereditary glaucoma

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol GpnmbR150X
Allele Name iris pigment dispersion
Allele Type Spontaneous
Common Name(s) Gpnmbipd;
Strain of OriginDBA/2J
Gene Symbol and Name Gpnmb, glycoprotein (transmembrane) nmb
Chromosome 6
Gene Common Name(s) Dchil; HGFIN; NMB; Osteoactivin; dendritic cell associated heparan sulfate proteoglycans dependent integrin ligand; ipd; iris pigment dispersion;
General Note

The mouse strain DBA/2J develops glaucoma associated with iris stromal atrophy and iris pigment dispersion phneotypes. Genetic studies defined two separate loci that contribute to the overall phenotype in the DBA/2J mouse, ipd and isa. Either mutation in a homozygous state contributes to glaucoma, while mice homozygous for both mutations develop an earlier onset and more severe iris disease.

Molecular Note The underlying mutation responsible for the phenotype in the iris pigment dispersion mouse was identified as a C to T substitution that resulted in a nonsense mutation, Arg150stop. [MGI Ref ID J:75398]
 
Allele Symbol Tyrp1isa
Allele Name iris stromal atrophy
Allele Type Spontaneous
Common Name(s) isa;
Strain of OriginDBA/2J
Gene Symbol and Name Tyrp1, tyrosinase-related protein 1
Chromosome 4
Gene Common Name(s) B; CAS2; CATB; GP75; OCA3; TRP; TRP-1; TRP1; TYRP; Tyrp; b; b-PROTEIN; brown; iris stromal atrophy; isa; tyrosinase-related protein;
General Note

The mouse strain DBA/2J develops glaucoma associated with iris stromal atrophy and iris pigment dispersion phneotypes. Genetic studies defined two separate loci that contribute to the overall phenotype in the DBA/2J mouse, ipd and isa. Either mutation in a homozygous state contributes to glaucoma, while mice homozygous for both mutations develop an earlier onset and more severe iris disease.

Molecular Note Expression of a BAC containing the wild-type Tyrp1 gene rescues the phenotype of isa mice. The isa phenotype has been identified in numerous aged stocks carrying Tyrp1b allele. It is therefore most probable, that the Tyrp1b alleleis responsible for the isa phenotype. [MGI Ref ID J:75398]

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Anderson MG; Smith RS; Savinova OV; Hawes NL; Chang B; Zabaleta A; Wilpan R; Heckenlively JR; Davisson M; John SW. 2001. Genetic modification of glaucoma associated phenotypes between AKXD-28/Ty and DBA/2J mice. BMC Genet 2(1):1. [PubMed: 11178107]  [MGI Ref ID J:82878]

GpnmbR150X related

Abdelmagid SM; Barbe MF; Rico MC; Salihoglu S; Arango-Hisijara I; Selim AH; Anderson MG; Owen TA; Popoff SN; Safadi FF. 2008. Osteoactivin, an anabolic factor that regulates osteoblast differentiation and function. Exp Cell Res 314(13):2334-51. [PubMed: 18555216]  [MGI Ref ID J:138006]

Abdelmagid SM; Belcher JY; Moussa FM; Lababidi SL; Sondag GR; Novak KM; Sanyurah AS; Frara NA; Razmpour R; Del Carpio-Cano FE; Safadi FF. 2014. Mutation in Osteoactivin Decreases Bone Formation in Vivo and Osteoblast Differentiation in Vitro. Am J Pathol 184(3):697-713. [PubMed: 24462663]  [MGI Ref ID J:206565]

Anderson MG; Libby RT; Mao M; Cosma IM; Wilson LA; Smith RS; John SW. 2006. Genetic context determines susceptibility to intraocular pressure elevation in a mouse pigmentary glaucoma. BMC Biol 4:20. [PubMed: 16827931]  [MGI Ref ID J:128215]

Anderson MG; Nair KS; Amonoo LA; Mehalow A; Trantow CM; Masli S; John SW. 2008. GpnmbR150X allele must be present in bone marrow derived cells to mediate DBA/2J glaucoma. BMC Genet 9:30. [PubMed: 18402690]  [MGI Ref ID J:134670]

Anderson MG; Smith RS; Hawes NL; Zabaleta A; Chang B; Wiggs JL; John SW. 2002. Mutations in genes encoding melanosomal proteins cause pigmentary glaucoma in DBA/2J mice. Nat Genet 30(1):81-5. [PubMed: 11743578]  [MGI Ref ID J:75398]

Anderson MG; Smith RS; Savinova OV; Hawes NL; Chang B; Zabaleta A; Wilpan R; Heckenlively JR; Davisson M; John SW. 2001. Genetic modification of glaucoma associated phenotypes between AKXD-28/Ty and DBA/2J mice. BMC Genet 2(1):1. [PubMed: 11178107]  [MGI Ref ID J:82878]

Barabas P; Huang W; Chen H; Koehler CL; Howell G; John SW; Tian N; Renteria RC; Krizaj D. 2011. Missing optomotor head-turning reflex in the DBA/2J mouse. Invest Ophthalmol Vis Sci 52(9):6766-73. [PubMed: 21757588]  [MGI Ref ID J:181395]

Chang B; Hawes NL; Hurd RE; Wang J; Howell D; Davisson MT; Roderick TH; Nusinowitz S; Heckenlively JR. 2005. Mouse models of ocular diseases. Vis Neurosci 22(5):587-93. [PubMed: 16332269]  [MGI Ref ID J:156373]

Chang B; Smith RS; Hawes NL; Anderson MG; Zabaleta A; Savinova O ; Roderick TH ; Heckenlively JR ; Davisson MT ; John SW. 1999. Interacting loci cause severe iris atrophy and glaucoma in DBA/2J mice. Nat Genet 21(4):405-9. [PubMed: 10192392]  [MGI Ref ID J:54013]

Crish SD; Dapper JD; MacNamee SE; Balaram P; Sidorova TN; Lambert WS; Calkins DJ. 2013. Failure of axonal transport induces a spatially coincident increase in astrocyte BDNF prior to synapse loss in a central target. Neuroscience 229:55-70. [PubMed: 23159315]  [MGI Ref ID J:193975]

Harder JM; Fernandes KA; Libby RT. 2012. The Bcl-2 family member BIM has multiple glaucoma-relevant functions in DBA/2J mice. Sci Rep 2:530. [PubMed: 22833783]  [MGI Ref ID J:207269]

Howell GR; Libby RT; Jakobs TC; Smith RS; Phalan FC; Barter JW; Barbay JM; Marchant JK; Mahesh N; Porciatti V; Whitmore AV; Masland RH; John SW. 2007. Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma. J Cell Biol 179(7):1523-37. [PubMed: 18158332]  [MGI Ref ID J:131073]

Howell GR; Macalinao DG; Sousa GL; Walden M; Soto I; Kneeland SC; Barbay JM; King BL; Marchant JK; Hibbs M; Stevens B; Barres BA; Clark AF; Libby RT; John SW. 2011. Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma. J Clin Invest 121(4):1429-44. [PubMed: 21383504]  [MGI Ref ID J:172016]

Huang W; Xing W; Ryskamp DA; Punzo C; Krizaj D. 2011. Localization and phenotype-specific expression of ryanodine calcium release channels in C57BL6 and DBA/2J mouse strains. Exp Eye Res 93(5):700-9. [PubMed: 21933672]  [MGI Ref ID J:189480]

Inman DM; Sappington RM; Horner PJ; Calkins DJ. 2006. Quantitative correlation of optic nerve pathology with ocular pressure and corneal thickness in the DBA/2 mouse model of glaucoma. Invest Ophthalmol Vis Sci 47(3):986-96. [PubMed: 16505033]  [MGI Ref ID J:108329]

Jakobs TC; Libby RT; Ben Y; John SW; Masland RH. 2005. Retinal ganglion cell degeneration is topological but not cell type specific in DBA/2J mice. J Cell Biol 171(2):313-25. [PubMed: 16247030]  [MGI Ref ID J:104518]

Libby RT; Li Y; Savinova OV; Barter J; Smith RS; Nickells RW; John SW. 2005. Susceptibility to neurodegeneration in a glaucoma is modified by bax gene dosage. PLoS Genet 1(1):e4. [PubMed: 16103918]  [MGI Ref ID J:100118]

Ripoll VM; Irvine KM; Ravasi T; Sweet MJ; Hume DA. 2007. Gpnmb is induced in macrophages by IFN-gamma and lipopolysaccharide and acts as a feedback regulator of proinflammatory responses. J Immunol 178(10):6557-66. [PubMed: 17475886]  [MGI Ref ID J:146106]

Trantow CM; Cuffy TL; Fingert JH; Kuehn MH; Anderson MG. 2011. Microarray analysis of iris gene expression in mice with mutations influencing pigmentation. Invest Ophthalmol Vis Sci 52(1):237-48. [PubMed: 20739468]  [MGI Ref ID J:171565]

Zhou X; Li F; Kong L; Tomita H; Li C; Cao W. 2005. Involvement of inflammation, degradation, and apoptosis in a mouse model of glaucoma. J Biol Chem 280(35):31240-8. [PubMed: 15985430]  [MGI Ref ID J:101163]

Tyrp1isa related

Anderson MG; Smith RS; Hawes NL; Zabaleta A; Chang B; Wiggs JL; John SW. 2002. Mutations in genes encoding melanosomal proteins cause pigmentary glaucoma in DBA/2J mice. Nat Genet 30(1):81-5. [PubMed: 11743578]  [MGI Ref ID J:75398]

Anderson MG; Smith RS; Savinova OV; Hawes NL; Chang B; Zabaleta A; Wilpan R; Heckenlively JR; Davisson M; John SW. 2001. Genetic modification of glaucoma associated phenotypes between AKXD-28/Ty and DBA/2J mice. BMC Genet 2(1):1. [PubMed: 11178107]  [MGI Ref ID J:82878]

Barabas P; Huang W; Chen H; Koehler CL; Howell G; John SW; Tian N; Renteria RC; Krizaj D. 2011. Missing optomotor head-turning reflex in the DBA/2J mouse. Invest Ophthalmol Vis Sci 52(9):6766-73. [PubMed: 21757588]  [MGI Ref ID J:181395]

Chang B; Hawes NL; Hurd RE; Wang J; Howell D; Davisson MT; Roderick TH; Nusinowitz S; Heckenlively JR. 2005. Mouse models of ocular diseases. Vis Neurosci 22(5):587-93. [PubMed: 16332269]  [MGI Ref ID J:156373]

Chang B; Smith RS; Hawes NL; Anderson MG; Zabaleta A; Savinova O ; Roderick TH ; Heckenlively JR ; Davisson MT ; John SW. 1999. Interacting loci cause severe iris atrophy and glaucoma in DBA/2J mice. Nat Genet 21(4):405-9. [PubMed: 10192392]  [MGI Ref ID J:54013]

Inman DM; Sappington RM; Horner PJ; Calkins DJ. 2006. Quantitative correlation of optic nerve pathology with ocular pressure and corneal thickness in the DBA/2 mouse model of glaucoma. Invest Ophthalmol Vis Sci 47(3):986-96. [PubMed: 16505033]  [MGI Ref ID J:108329]

Jakobs TC; Libby RT; Ben Y; John SW; Masland RH. 2005. Retinal ganglion cell degeneration is topological but not cell type specific in DBA/2J mice. J Cell Biol 171(2):313-25. [PubMed: 16247030]  [MGI Ref ID J:104518]

John SW; Anderson MG; Smith RS. 1999. Mouse genetics: a tool to help unlock the mechanisms of glaucoma. J Glaucoma 8(6):400-12. [PubMed: 10604301]  [MGI Ref ID J:59796]

Libby RT; Li Y; Savinova OV; Barter J; Smith RS; Nickells RW; John SW. 2005. Susceptibility to neurodegeneration in a glaucoma is modified by bax gene dosage. PLoS Genet 1(1):e4. [PubMed: 16103918]  [MGI Ref ID J:100118]

Zhou X; Li F; Kong L; Tomita H; Li C; Cao W. 2005. Involvement of inflammation, degradation, and apoptosis in a mouse model of glaucoma. J Biol Chem 280(35):31240-8. [PubMed: 15985430]  [MGI Ref ID J:101163]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3300.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $4290.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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