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Strain Name:

C57BL/6J-Hbbd3th/J

Stock Number:

000996

Availability:

Repository-Cryopreserved

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General Terms and Conditions

Genes & Alleles   Hbb;   Hbbd3th;

Product Information

Strain Details

Type JAX® GEMM® Strain - Chemically Induced Mutation
Additional information on JAX® GEMM® Strains.
Type JAX® GEMM® Strain - Mutant Strain
Specieslaboratory mouse
GenerationN25p
Related Disease (OMIM) Terms

Beta Thalassemia, Dominant Inclusion Body Type
Hemoglobin--Beta Locus; HBB
Mammalian Phenotype Terms assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Hbbd3th/Hbbd3th

        involves: C57BL/6 * DBA/2J
  • lethality-postnatal
  • postnatal lethality (MGI Ref ID J:7209)
    • although born at normal ratios, 37% die before weaning
    • survival from weaning to 5 months of age is normal
  • hematopoietic system phenotype
  • abnormal red blood cell (MGI Ref ID J:7209)
    • abnormal erythrocyte morphology (MGI Ref ID J:7209)
      • anisopoikilocytosis (MGI Ref ID J:7209)
        • anisocytosis (MGI Ref ID J:7209)
          • variable size of RBCs
        • poikilocytosis (MGI Ref ID J:7209)
      • decreased mean corpuscular volume (MGI Ref ID J:7209)
      • hyperchromasia (MGI Ref ID J:7209)
        • increased numbers of nucleated RBCs
      • low mean erythrocyte cell number (MGI Ref ID J:7209)
        • RBC counts reduced to around 10.2 x 106/mm3
      • microcytosis (MGI Ref ID J:7209)
        • large numbers of microcytes and cellular debris
    • decreased hematocrit (MGI Ref ID J:7209)
      • around 37%
    • hemoglobin abnormalities (MGI Ref ID J:7209)
      • reduced hemoglobin
      • beta major hemoglobin is absent
      • beta minor hemoglobin is elevated to about 24.6%
      • abnormal hemoglobin content (MGI Ref ID J:7209)
        • beta/alpha hemoglobin ratio is reduced
      • decreased mean corpuscular hemoglobin (MGI Ref ID J:7209)
  • reticulocytosis (MGI Ref ID J:7209)
  • reproductive system phenotype
  • decreased litter size (MGI Ref ID J:7209)
    • reduced size of litters produced by females

Gene & Allele Details

Allele Symbol Hbbd3th
Allele Name beta-thalassemia
Common Name(s) Hbbth-1; betaMDD; betamajor;
Strain of OriginDBA/2J
Gene Symbol and Name Hbb, hemoglobin beta chain complex
Chromosome 7
Gene Common Name(s) CD113t-C; HBD;
Molecular Note A 3.7 kb region, including the entire beta major globin gene and 2 kilobases of 5' flanking region, is deleted. A novel approximately 66 bp sequence ending in a poly(A) stretch was found to bridge the deletion. [MGI Ref ID J:8395]

Colony Maintenance

Breeding & HusbandryThese mice must be tested for heterozygosity and the mice need to be 7 weeks of age in order to be tested

Related Strains

View Strains carrying other alleles of Hbb     (11 strains)

Research Applications

This mouse can be used to support research in many areas including:

Hematological Research
Hemoglobin Defects (betaO-thalassemia)
Hemoglobin Defects (thalassemia)

References

Selected Reference(s)

Skow LC; Burkhart BA; Johnson FM; Popp RA; Popp DM; Goldberg SZ; Anderson WF; Barnett LB; Lewis SE. 1983. A mouse model for beta-thalassemia. Cell 34(3):1043-52. [PubMed: 6313205]  [MGI Ref ID J:7209]

Additional References

Price and Supply Information

Strain Name: C57BL/6J-Hbbd3th/J
Stock Number: 000996

Price Details

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Supply Details

Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes Cryorecovery - Standard.
The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.

Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services: Tel: 1-800-422-6423 or 1-207-288-5845; Email: jaxservices@jax.org.

LicensingSee General Terms and Conditions below  

General Terms and Conditions

View JAX® Mice & Services Conditions of Use.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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