Strain Name: |
RBD/DnJ |
|---|---|
Stock Number: |
001000 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Genes & Alleles | Mc1r; Mc1rE-tob; Rb(11.13)4Bnr; Rb(16.17)7Bnr; Rb(5.15)3Bnr; ; |
Product Information
Strain Details
Type Chromosome Aberration Additional information on Mice with Chromosomal Aberrations. Type Inbred Strain Additional information on Inbred Strains. Type Robertsonian Additional information on Mice with Chromosomal Aberrations. Type Translocation Additional information on Mice with Chromosomal Aberrations. Species laboratory mouse Generation F60pF61 (29-FEB-04) Appearance
tobacco darkening
Related Genotype: Mc1rE-tob/Mc1rE-tob
Gene & Allele Details
| Allele Symbol | Mc1rE-tob | ||
|---|---|---|---|
| Allele Name | tobacco darkening | ||
| Common Name(s) | Etob; | ||
| Strain of Origin | M. m. domesticus poschiavinus | ||
| Gene Symbol and Name | Mc1r, melanocortin 1 receptor | ||
| Chromosome | 8 | ||
| Gene Common Name(s) | MGC14337; MSH-R; Mshra; SHEP2; Tob; e; extension recessive yellow; extension, recessive yellow; melanocyte hormone receptor alpha; tobacco darkening; | ||
| General Note | Mc1rE-tob, tobacco darkening, semidominant. Formerly Etob. Mice of the species Mus poschiavinus, the tobacco mouse, are homozygous for this allele. They are black in color until the eighth week, after which the flanks become agouti.In descendants from crosses with Mus musculus, Mc1rE-tob/+ heterozygotes show an agouti pattern with darkened back. Mc1rE-tob/Mc1re a/a mice are black (J:22593, J:13641). The Mc1rE-tob allele carries two point mutations that result in a receptor that is overactive, though responsive to hormone regulation, and produces a greater activation of the MC1R effector, G protein-coupled adenylyl cyclase, than does the wild type allele (J:4636). | ||
| Molecular Note | A C-to-T mutation in codon 69 is predicted to result in a serine to leucine alteration at this position. [MGI Ref ID J:4636] | ||
| Gene Symbol and Name | Rb(11.13)4Bnr, Robertsonian translocation, Chr 11 and 13, Universitat Bonn/Rhein 4 | ||
| Chromosome | 13 | ||
| Gene Common Name(s) | Rb4Bnr; | ||
| Gene Symbol and Name | Rb(5.15)3Bnr, Robertsonian translocation, Chr 5 and 15, Universitat Bonn/Rhein 3 | ||
| Chromosome | 5 | ||
| Gene Common Name(s) | Rb3Bnr; | ||
| Gene Symbol and Name | Rb(16.17)7Bnr, Robertsonian translocation, Chr 16 and 17, Universitat Bonn/Rhein 7 | ||
| Chromosome | 17 | ||
| Gene Common Name(s) | Rb7Bnr; | ||
| Gene Symbol and Name | Rb(11.13)4Bnr, Robertsonian translocation, Chr 11 and 13, Universitat Bonn/Rhein 4 | ||
| Chromosome | 11 | ||
| Gene Common Name(s) | Rb4Bnr; | ||
| Gene Symbol and Name | Rb(5.15)3Bnr, Robertsonian translocation, Chr 5 and 15, Universitat Bonn/Rhein 3 | ||
| Chromosome | 15 | ||
| Gene Common Name(s) | Rb3Bnr; | ||
| Gene Symbol and Name | Rb(16.17)7Bnr, Robertsonian translocation, Chr 16 and 17, Universitat Bonn/Rhein 7 | ||
| Chromosome | 16 | ||
| Gene Common Name(s) | Rb7Bnr; | ||
Related Strains
Combined Robertsonian Chromosome Stocks
002040 RB126Bnr/EiJ 002041 RB16Bnr/EiJ 000726 RBF/DnJ 000807 RBJ/DnJ 000896 STOCK Rb(2.18)6Rma Rb(12.14)8Rma/J 000864 STOCK Rb(2.8)2Lub Rb(7.18)9Lub/J 000929 TIRANO/EiJ 001746 WMP/PasDnJ 001392 ZALENDE/EiJ View Combined Robertsonian Chromosome Stocks (9 strains)
Research Applications
This mouse can be used to support research in many areas including:
Mc1rE-tob relatedResearch Tools
Genetics Research (Gene Mapping)
Endocrine Deficiency Research
Skin Defects
References
Additional ReferencesPrice and Supply Information
| Strain Name: | RBD/DnJ |
| Stock Number: | 001000 |
Price Details
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Request Form |
Strain from the Cytogenetic Models Resource. First time use requires submission of a Request Form, please inquire. |
| Licensing | See General Terms and Conditions below |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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