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- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
- Health & care
- References
- Pricing & purchasing
- Terms of use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Type Chromosome Aberration; Robertsonian; Translocation; Additional information on Mice with Chromosomal Aberrations. Type Inbred Strain; Additional information on Inbred Strains. Visit our online Nomenclature tutorial. Species laboratory mouse Generation F60pF61 (29-FEB-04)
Generation DefinitionsAppearance
tobacco darkening
Related Genotype: Mc1rE-tob/Mc1rE-tob
Related Strains
Combined Robertsonian Chromosome Stocks
002040 RB126Bnr/EiJ 002041 RB16Bnr/EiJ 000726 RBF/DnJ 000807 RBJ/DnJ 000896 STOCK Rb(2.18)6Rma Rb(12.14)8Rma/J 000864 STOCK Rb(2.8)2Lub Rb(7.18)9Lub/J 000929 TIRANO/EiJ 001746 WMP/PasDnJ 001392 ZALENDE/EiJ View Combined Robertsonian Chromosome Stocks (9 strains)
000726 RBF/DnJ 000807 RBJ/DnJ 000729 STOCK Rb(11.13)4Bnr/J
003625 B6.C-H2-Ab1bm12/KhEg-Mc1re-J/J 001434 C3HeB/FeJ x STX/Le-Mc1rE-so Gli3Xt-J Zeb1Tw/J 001533 C3HeB/FeJ-Mc1rE-so Gli3Xt-J/J 000060 C57BL/6J-Mc1re/J
001795 B6Ei.Cg-Rb(11.13)4Bnr/J 000729 STOCK Rb(11.13)4Bnr/J 000929 TIRANO/EiJ 001392 ZALENDE/EiJ
000807 RBJ/DnJ 000615 STOCK Rb(16.17)7Bnr 003304 STOCK Rb(16.17)7Bnr-Myo15sh2-2J/J 000929 TIRANO/EiJ 001392 ZALENDE/EiJ
000807 RBJ/DnJ 000929 TIRANO/EiJ 001392 ZALENDE/EiJ
Phenotype
Phenotype Information
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested. Albinism, Oculocutaneous, Type II; OCA2 (MC1R)
Melanoma, Cutaneous Malignant, Susceptibility to, 5; CMM5 (MC1R)
This mouse can be used to support research in many areas including:
Mc1rE-tob relatedResearch Tools
Genetics Research
Gene Mapping
Endocrine Deficiency Research
Skin Defects
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Mc1rE-tob | ||
|---|---|---|---|
| Allele Name | tobacco darkening | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | Etob; | ||
| Strain of Origin | M. m. domesticus poschiavinus | ||
| Gene Symbol and Name | Mc1r, melanocortin 1 receptor | ||
| Chromosome | 8 | ||
| Gene Common Name(s) | CMM5; MSH-R; Mshra; SHEP2; Tob; e; extension recessive yellow; extension, recessive yellow; melanocyte hormone receptor alpha; tobacco darkening; | ||
| General Note | Mc1rE-tob, tobacco darkening, semidominant. Formerly Etob. Mice of the species Mus poschiavinus, the tobacco mouse, are homozygous for this allele. They are black in color until the eighth week, after which the flanks become agouti.In descendants from crosses with Mus musculus, Mc1rE-tob/+ heterozygotes show an agouti pattern with darkened back. Mc1rE-tob/Mc1re a/a mice are black (J:22593, J:13641). The Mc1rE-tob allele carries two point mutations that result in a receptor that is overactive, though responsive to hormone regulation, and produces a greater activation of the MC1R effector, G protein-coupled adenylyl cyclase, than does the wild-type allele (J:4636). | ||
| Molecular Note | Two independent PCR assays found a C-to-T mutation at position 206 predicted to result in a serine to leucine alteration in codon 69. A second nucleotide C-to-T change results in a silent mutation at position 166. [MGI Ref ID J:4636] | ||
| Gene Symbol and Name | Rb(16.17)7Bnr, Robertsonian translocation, Chr 16 and 17, Universitat Bonn/Rhein 7 | ||
| Chromosome | 17 | ||
| Gene Common Name(s) | Rb7Bnr; | ||
| Gene Symbol and Name | Rb(5.15)3Bnr, Robertsonian translocation, Chr 5 and 15, Universitat Bonn/Rhein 3 | ||
| Chromosome | 15 | ||
| Gene Common Name(s) | Rb3Bnr; | ||
| Gene Symbol and Name | Rb(11.13)4Bnr, Robertsonian translocation, Chr 11 and 13, Universitat Bonn/Rhein 4 | ||
| Chromosome | 13 | ||
| Gene Common Name(s) | Rb4Bnr; | ||
| Gene Symbol and Name | Rb(16.17)7Bnr, Robertsonian translocation, Chr 16 and 17, Universitat Bonn/Rhein 7 | ||
| Chromosome | 16 | ||
| Gene Common Name(s) | Rb7Bnr; | ||
| Gene Symbol and Name | Rb(11.13)4Bnr, Robertsonian translocation, Chr 11 and 13, Universitat Bonn/Rhein 4 | ||
| Chromosome | 11 | ||
| Gene Common Name(s) | Rb4Bnr; | ||
| Gene Symbol and Name | Rb(5.15)3Bnr, Robertsonian translocation, Chr 5 and 15, Universitat Bonn/Rhein 3 | ||
| Chromosome | 5 | ||
| Gene Common Name(s) | Rb3Bnr; | ||
References
References provided by MGI
Additional References
Robbins LS; Nadeau JH; Johnson KR; Kelly MA; Roselli-Rehfuss L; Baack E; Mountjoy KG; Cone RD. 1993. Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function. Cell 72(6):827-34. [PubMed: 8458079] [MGI Ref ID J:4636]
Mc1rE-tob relatedGropp A; Tettenborn U; Lehmann E von. 1969. [Chromosome studies in the tobacco mouse (M. poschiavinus) and in tobacco mouse hybrids] Experientia 25(8):875-6. [PubMed: 5348563] [MGI Ref ID J:24452]
Gropp A; Tettenborn U; Lehmann E von. 1970. [Chromosome variations on the Robertson type in the tobacco mouse, M. Poschiavinus, and its hybrids with the laboratory mouse] Cytogenetics 9(1):9-23. [PubMed: 5412048] [MGI Ref ID J:23097]
Robbins LS; Nadeau JH; Johnson KR; Kelly MA; Roselli-Rehfuss L; Baack E; Mountjoy KG; Cone RD. 1993. Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function. Cell 72(6):827-34. [PubMed: 8458079] [MGI Ref ID J:4636]
Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York. [MGI Ref ID J:78801]
von Lehmann E. 1973. Coat colour genetics of the tobacco-mouse (Mus poschiavinus Fatio) Mouse News Lett 48:23. [MGI Ref ID J:22593]
von Lehmann E. 1974. Weitere Mitteilungen zu: coat colour genetics of the tobacco-mouse (Mus poschiavinus Fatio). Mouse News Lett 50:26-7. [MGI Ref ID J:13641]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $3175.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
Cryorecovery of Strains Needing Progeny Testing
At least two untested males and two untested females (two pairs) will be recovered (eight or more mice is typical). The total number of animals provided, their gender and genotype will vary. Untested animals typically are available to ship between 13 and 16 weeks from the date of your order. If the first recovery attempt is unsuccessful, a second recovery will be done, extending the overall recovery time to approximately 25 weeks. Progeny testing is required to identify the genotype of mice of this strain, as a genotyping assay is not available. This type of testing involves breeding the recovered animals and assessing the phenotype of the offspring in order to identify animals carrying the mutation of interest. We can perform the progeny testing for you as a service or we can ship all recovered animals to you for progeny testing at your facility. If you perform the progeny testing, there is NO guarantee that a carrier will be identified. If we perform progeny testing as a service, additional breeding time will be required. In this case, when a male and female (one pair) are identified that carry the mutation, they and their offspring will be shipped. Delivery time for strains requiring progeny testing often exceeds 25 weeks and may take 12 months or more due to the difficulties in breeding some strains. The progeny testing cost is in addition to the recovery cost and is based on the number of boxes used and the time taken to produce the mice identified as carrying the mutation.
Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation.
Please contact Customer Service for more information on the cost of progeny testing for a strain: Tel: 1-800-422-6423 or 1-207-288-5845 (from any location). The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.
Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
| Pricing for International shipping destinations |
|
Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $4127.50 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
Cryorecovery of Strains Needing Progeny Testing
At least two untested males and two untested females (two pairs) will be recovered (eight or more mice is typical). The total number of animals provided, their gender and genotype will vary. Untested animals typically are available to ship between 13 and 16 weeks from the date of your order. If the first recovery attempt is unsuccessful, a second recovery will be done, extending the overall recovery time to approximately 25 weeks. Progeny testing is required to identify the genotype of mice of this strain, as a genotyping assay is not available. This type of testing involves breeding the recovered animals and assessing the phenotype of the offspring in order to identify animals carrying the mutation of interest. We can perform the progeny testing for you as a service or we can ship all recovered animals to you for progeny testing at your facility. If you perform the progeny testing, there is NO guarantee that a carrier will be identified. If we perform progeny testing as a service, additional breeding time will be required. In this case, when a male and female (one pair) are identified that carry the mutation, they and their offspring will be shipped. Delivery time for strains requiring progeny testing often exceeds 25 weeks and may take 12 months or more due to the difficulties in breeding some strains. The progeny testing cost is in addition to the recovery cost and is based on the number of boxes used and the time taken to produce the mice identified as carrying the mutation.
Please note that identified pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation.
Please contact Customer Service for more information on the cost of progeny testing for a strain: Tel: 1-800-422-6423 or 1-207-288-5845 (from any location). The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.
Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
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Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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For Licensing and Use Restrictions view the link(s) below:
- Strain from the Cytogenetic Models Resource. First time use requires submission of a Request Form, please inquire.
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JAX® Mice, Products & Services Conditions of Use
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